MCID: NRN016
MIFTS: 40

Neuronal Migration Disorders

Categories: Neuronal diseases

Aliases & Classifications for Neuronal Migration Disorders

MalaCards integrated aliases for Neuronal Migration Disorders:

Name: Neuronal Migration Disorders 53
Abnormality of Neuronal Migration 29 6
Malformations of Cortical Development, Group Ii 71
Neuronal Migration Disorder 36

Classifications:



External Ids:

KEGG 36 H01835
UMLS 71 C1837249

Summaries for Neuronal Migration Disorders

NINDS : 53 Neuronal migration disorders (NMDs) are a group of birth defects caused by the abnormal migration of neurons in the developing brain and nervous system. In the developing brain, neurons must migrate from the areas where they are born to the areas where they will settle into their proper neural circuits. Neuronal migration, which occurs as early as the second month of gestation, is controlled by a complex assortment of chemical guides and signals. When these signals are absent or incorrect, neurons do not end up where they belong. This can result in structurally abnormal or missing areas of the brain in the cerebral hemispheres, cerebellum, brainstem, or hippocampus. The structural abnormalities found in NMDs include schizencephaly, porencephaly, lissencephaly, agyria, macrogyria, polymicrogyria, pachygyria, microgyria, micropolygyria, neuronal heterotopias (including band heterotopia), agenesis of the corpus callosum, and agenesis of the cranial nerves. Symptoms vary according to the abnormality, but often feature poor muscle tone and motor function, seizures, developmental delays, impaired cognitive development, failure to grow and thrive, difficulties with feeding, swelling in the extremities, and a smaller than normal head. Most infants with an NMD appear normal, but some disorders have characteristic facial or skull features that can be recognized by a neurologist. Several genetic abnormalities in children with NMDs have been identified. Defects in genes that are involved in neuronal migration have been associated with NMDs, but the role they play in the development of these disorders is not yet well-understood. More than 25 syndromes resulting from abnormal neuronal migration have been described. Among them are syndromes with several different patterns of inheritance; genetic counseling thus differs greatly between syndromes.

MalaCards based summary : Neuronal Migration Disorders, also known as abnormality of neuronal migration, is related to lissencephaly 1 and lissencephaly, x-linked, 1. An important gene associated with Neuronal Migration Disorders is DYNC1H1 (Dynein Cytoplasmic 1 Heavy Chain 1), and among its related pathways/superpathways are Neuroscience and Cytoskeletal Signaling. Affiliated tissues include brain, cerebellum and cortex, and related phenotypes are behavior/neurological and cellular

KEGG : 36 Neuronal migration disorders (NMD) are developmental malformations of the cerebral hemispheres, frequently associated with severe epilepsy. They can be defined as cerebral malformations characterised by malpositioning and faulty differentiation of cortical grey matter. Neuronal positioning is an integral part of the coordinated steps comprising neural circuit formation in embryonic and neonatal development. Correct positioning of neurons by normal migration plays a critical role in establishing cognitive functions and emotion. The causes of brain malformations associated with positioning and migration defects are varied and include genetic mutations and environmental toxins. Studies of neuronal migration disorders have progressed due to advances in molecular genetics and brain magnetic resonance imaging.

Wikipedia : 74 Neuronal migration disorder (NMD) refers to a heterogenous group of disorders that, it is supposed,... more...

Related Diseases for Neuronal Migration Disorders

Diseases related to Neuronal Migration Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 lissencephaly 1 32.3 RELN PAFAH1B1 DCX
2 lissencephaly, x-linked, 1 30.4 PAFAH1B1 DCX
3 cerebellar hypoplasia 30.4 RELN PAFAH1B1
4 lissencephaly 30.3 WDR62 TUBA1A RELN PAFAH1B1 DYNC1H1 DCX
5 pachygyria 30.1 TUBA1A PAFAH1B1 ADGRG1
6 polymicrogyria 29.9 SCN1A ADGRG1
7 lissencephaly with cerebellar hypoplasia 29.9 RELN PAFAH1B1 DCX
8 zellweger syndrome 29.8 VIM PAFAH1B1 DCX
9 focal epilepsy 29.8 SCN1A RELN DCX
10 hypomelanosis of ito 29.8 PAFAH1B1 ARFGEF2
11 hydranencephaly 29.4 TUBA1A PAFAH1B1
12 hydrocephalus 28.9 VIM RELN ARFGEF2 ADGRG1
13 miller-dieker lissencephaly syndrome 28.6 TUBA1A RELN PAFAH1B1 DCX ARFGEF2
14 walker-warburg syndrome 28.6 TUBA1A RELN PAFAH1B1 ARFGEF2 ADGRG1
15 west syndrome 28.4 TUBA1A SCN1A RELN PAFAH1B1 ARFGEF2
16 periventricular nodular heterotopia 28.0 WDR62 TUBA1A RELN PAFAH1B1 DCX ARFGEF2
17 microcephaly 27.4 WDR62 TUBA1A SCN1A DYNC1H1 ARFGEF2 ADGRG1
18 band heterotopia 27.3 WDR62 TUBA1A RELN PAFAH1B1 DYNC1H1 DCX
19 flna-related periventricular nodular heterotopia 11.5
20 colpocephaly 11.5
21 pachygyria with mental retardation, seizures, and arachnoid cysts 11.2
22 polymicrogyria with or without vascular-type ehlers-danlos syndrome 10.5
23 schizencephaly 10.4
24 hemimegalencephaly 10.3
25 epilepsy 10.2
26 chromosome 17p13.3, centromeric, duplication syndrome 10.2 PAFAH1B1 DCX
27 muscular dystrophy, congenital, lmna-related 10.2
28 muscular dystrophy 10.2
29 visual epilepsy 10.2
30 seizure disorder 10.2
31 alacrima, achalasia, and mental retardation syndrome 10.1
32 corpus callosum, agenesis of 10.1
33 cortical dysplasia, complex, with other brain malformations 7 10.1
34 pseudobulbar palsy 10.1
35 corpus callosum, agenesis of, with facial anomalies and cerebellar ataxia 10.0
36 tuberous sclerosis 10.0
37 status epilepticus 10.0
38 cerebral palsy 10.0
39 holoprosencephaly 10.0
40 hypotonia 10.0
41 cobblestone lissencephaly 10.0
42 benign ependymoma 10.0 VIM DCX
43 aicardi syndrome 9.9 WDR62 ADGRG1
44 muscular dystrophy-dystroglycanopathy , type a, 1 9.9
45 muscular dystrophy-dystroglycanopathy , type a, 4 9.9
46 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 9.9
47 early infantile epileptic encephalopathy 9.9
48 autosomal recessive disease 9.9
49 dyslexia 9.9
50 rubella 9.9

Graphical network of the top 20 diseases related to Neuronal Migration Disorders:



Diseases related to Neuronal Migration Disorders

Symptoms & Phenotypes for Neuronal Migration Disorders

MGI Mouse Phenotypes related to Neuronal Migration Disorders:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.92 ADGRG1 DCX DYNC1H1 PAFAH1B1 RELN SCN1A
2 cellular MP:0005384 9.8 ADGRG1 ARFGEF2 PAFAH1B1 RELN TUBA1A VIM
3 growth/size/body region MP:0005378 9.76 ARFGEF2 DCX DYNC1H1 PAFAH1B1 RELN SCN1A
4 nervous system MP:0003631 9.65 ADGRG1 ARFGEF2 DCX DYNC1H1 PAFAH1B1 RELN
5 reproductive system MP:0005389 9.23 ADGRG1 DCX DYNC1H1 PAFAH1B1 RELN SCN1A

Drugs & Therapeutics for Neuronal Migration Disorders

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Human Epilepsy Genetics--Neuronal Migration Disorders Study Unknown status NCT00041600

Search NIH Clinical Center for Neuronal Migration Disorders

Genetic Tests for Neuronal Migration Disorders

Genetic tests related to Neuronal Migration Disorders:

# Genetic test Affiliating Genes
1 Abnormality of Neuronal Migration 29

Anatomical Context for Neuronal Migration Disorders

MalaCards organs/tissues related to Neuronal Migration Disorders:

40
Brain, Cerebellum, Cortex, Eye, Skin, Temporal Lobe, Fetal Brain

Publications for Neuronal Migration Disorders

Articles related to Neuronal Migration Disorders:

(show top 50) (show all 254)
# Title Authors PMID Year
1
Can we predict response to vagus nerve stimulation in intractable epilepsy. 61
31914344 2020
2
Interneuron dysfunction in epilepsy: An experimental approach using immature brain insults to induce neuronal migration disorders. 61
31419633 2019
3
SCN2A mutation in an infant with Ohtahara syndrome and neuroimaging findings: expanding the phenotype of neuronal migration disorders. 61
31204721 2019
4
Endosomal trafficking defects in patient cells with KIAA1109 biallelic variants. 61
30906834 2019
5
Toward a Better Understanding of Neuronal Migration Deficits in Autism Spectrum Disorders. 61
31620440 2019
6
Prenatal Environment That Affects Neuronal Migration. 61
31380373 2019
7
Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models. 61
30626593 2019
8
MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development. 61
30250269 2018
9
Neuronal Migration Disorders. 61
29298944 2018
10
Stereo-EEG: Diagnostic and therapeutic tool for periventricular nodular heterotopia epilepsies. 61
28880999 2017
11
Time-lapse Confocal Imaging of Migrating Neurons in Organotypic Slice Culture of Embryonic Mouse Brain Using In Utero Electroporation. 61
28784978 2017
12
Germline and somatic mutations in cortical malformations: Molecular defects in Argentinean patients with neuronal migration disorders. 61
28953922 2017
13
17p13.3 Microdeletion: Insights on Genotype-Phenotype Correlation. 61
28232781 2017
14
Genetic Basis of Brain Malformations. 61
27781032 2016
15
Neuronal migration disorders: Focus on the cytoskeleton and epilepsy. 61
26299390 2016
16
Utility of fetal MRI for workup of fetal central nervous system anomalies in an Australian maternal-fetal medicine cohort. 61
26852695 2016
17
A novel TUBB3 mutation in a sporadic patient with asymmetric cortical dysplasia. 61
26739025 2016
18
Models of cortical malformation--Chemical and physical. 61
25850077 2016
19
Effect of methotrexate exposure at late gestation on development of telencephalon in rat fetal brain. 61
26369365 2016
20
Central Nervous System and its Disease Models on a Chip. 61
26497426 2015
21
Brain size regulations by cbp haploinsufficiency evaluated by in-vivo MRI based volumetry. 61
26543002 2015
22
CHCHD2 is down-regulated in neuronal cells differentiated from iPS cells derived from patients with lissencephaly. 61
26188257 2015
23
Neuronal Migration Dynamics in the Developing Ferret Cortex. 61
26490868 2015
24
The relevance of human fetal subplate zone for developmental neuropathology of neuronal migration disorders and cortical dysplasia. 61
25312583 2015
25
Control of cortical neuronal migration by glutamate and GABA. 61
25688185 2015
26
Genotype-phenotype correlation in neuronal migration disorders and cortical dysplasias. 61
26052266 2015
27
Double Cortex Syndrome (Subcortical Band Heterotopia): A Case Report. 61
26221167 2015
28
Case report: Neuronal migration disorder associated with chromosome 15q13.3 duplication in a boy with autism and seizures. 61
24282185 2014
29
Etiologies for seizures around the time of vaccination. 61
25225143 2014
30
Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human. 61
24859200 2014
31
Accumulation of GABAergic neurons, causing a focal ambient GABA gradient, and downregulation of KCC2 are induced during microgyrus formation in a mouse model of polymicrogyria. 61
23246779 2014
32
Novel dynein DYNC1H1 neck and motor domain mutations link distal spinal muscular atrophy and abnormal cortical development. 61
24307404 2014
33
Rufinamide for the treatment of refractory epilepsy secondary to neuronal migration disorders. 61
24548548 2014
34
Neuronal migration and its disorders affecting the CA3 region. 61
24624057 2014
35
Ethnicity and geographic distribution of pediatric chronic ataxia in Manitoba. 61
24384334 2014
36
Malformations of cortical development and neocortical focus. 61
25078498 2014
37
The role of α-E-catenin in cerebral cortex development: radial glia specific effect on neuronal migration. 61
25147501 2014
38
Embryonic disruption of the candidate dyslexia susceptibility gene homolog Kiaa0319-like results in neuronal migration disorders. 61
23831424 2013
39
Expanding the spectrum of TUBA1A-related cortical dysgenesis to Polymicrogyria. 61
22948023 2013
40
Molecular networks of DYX1C1 gene show connection to neuronal migration genes and cytoskeletal proteins. 61
23036959 2013
41
Cytoskeleton in action: lissencephaly, a neuronal migration disorder. 61
23495356 2013
42
Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders. 61
23294285 2013
43
Small Rho-GTPases and cortical malformations: fine-tuning the cytoskeleton stability. 61
23524873 2013
44
Schizencephaly: a study of 16 patients. 61
21890242 2012
45
The dystrophin-glycoprotein complex in brain development and disease. 61
22626542 2012
46
Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells. 61
22595522 2012
47
Seckel syndrome accompanied by semilobar holoprosencephaly and arthrogryposis. 61
22353298 2012
48
Prenatal characteristics of infants with a neuronal migration disorder: a national-based study. 61
22548087 2012
49
[Usefulness of 123I-iomazenil SPECT in pediatric patients with neurological disease]. 61
22352023 2012
50
The thread-protective cell, a new cell performing multiple tasks. 61
22308909 2011

Variations for Neuronal Migration Disorders

ClinVar genetic disease variations for Neuronal Migration Disorders:

6 (show top 50) (show all 106) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 WDR62 NM_001083961.2(WDR62):c.2030T>C (p.Leu677Pro)SNV Pathogenic 208910 rs863223377 19:36581418-36581418 19:36090516-36090516
2 DYNC1H1 NM_001376.5(DYNC1H1):c.1738G>A (p.Glu580Lys)SNV Pathogenic 208862 rs863223361 14:102452300-102452300 14:101985963-101985963
3 SCN1A NM_006920.6(SCN1A):c.3294dup (p.Ser1099fs)duplication Pathogenic 599005 rs1559193213 2:166892659-166892660 2:166036149-166036150
4 TUBA1A NM_006009.4(TUBA1A):c.1148C>T (p.Ala383Val)SNV Pathogenic/Likely pathogenic 160143 rs587784482 12:49579001-49579001 12:49185218-49185218
5 DHX37 NM_032656.4(DHX37):c.1145A>G (p.Asp382Gly)SNV Likely pathogenic 691929 12:125455894-125455894 12:124971348-124971348
6 ATP1A2 NM_000702.4(ATP1A2):c.2105_2106del (p.Cys702fs)deletion Likely pathogenic 562228 rs1558008455 1:160105074-160105075 1:160135284-160135285
7 ATP1A2 NM_000702.4(ATP1A2):c.835del (p.Arg279fs)deletion Likely pathogenic 586989 rs1558005340 1:160097428-160097428 1:160127638-160127638
8 STX7 NM_003569.3(STX7):c.159A>C (p.Gln53His)SNV Likely pathogenic 218904 rs864309676 6:132793511-132793511 6:132472372-132472372
9 TTN , TTN-AS1 NM_001267550.2(TTN):c.32462C>T (p.Pro10821Leu)SNV Conflicting interpretations of pathogenicity 46867 rs146400809 2:179549988-179549988 2:178685261-178685261
10 TTN NM_001267550.2(TTN):c.88972A>G (p.Ile29658Val)SNV Conflicting interpretations of pathogenicity 178175 rs200193877 2:179418866-179418866 2:178554139-178554139
11 GYG2 NM_001079855.2(GYG2):c.340G>A (p.Asp114Asn)SNV Uncertain significance 208879 rs863223369 X:2773049-2773049 X:2855008-2855008
12 FAM47A NM_203408.3(FAM47A):c.127A>G (p.Met43Val)SNV Uncertain significance 208884 rs776397953 X:34150269-34150269 X:34132152-34132152
13 CFAP47 NM_001304548.2(CFAP47):c.8311A>G (p.Met2771Val)SNV Uncertain significance 208880 rs782477064 X:36329071-36329071 X:36310956-36310956
14 TTN NM_001267550.2(TTN):c.1051G>A (p.Val351Met)SNV Uncertain significance 208947 rs772889673 2:179659843-179659843 2:178795116-178795116
15 COL3A1 NM_000090.3(COL3A1):c.2110G>A (p.Glu704Lys)SNV Uncertain significance 208865 rs863223362 2:189864098-189864098 2:188999372-188999372
16 METTL1 NM_005371.6(METTL1):c.542T>C (p.Leu181Pro)SNV Uncertain significance 208908 rs863223376 12:58163379-58163379 12:57769596-57769596
17 PHF6 NM_001015877.2(PHF6):c.956G>C (p.Arg319Pro)SNV Uncertain significance 523390 rs1556019449 X:133551320-133551320 X:134417290-134417290
18 SLC38A5 NM_033518.4(SLC38A5):c.806T>C (p.Phe269Ser)SNV Uncertain significance 208881 rs863223370 X:48320149-48320149 X:48461763-48461763
19 HDAC6 NM_006044.4(HDAC6):c.1538G>A (p.Arg513His)SNV Uncertain significance 208882 rs782506012 X:48674592-48674592 X:48816185-48816185
20 NAP1L2 NM_021963.4(NAP1L2):c.508T>C (p.Ser170Pro)SNV Uncertain significance 208883 rs34995284 X:72433821-72433821 X:73213985-73213985
21 PNPLA4 NM_004650.3(PNPLA4):c.224G>A (p.Arg75Lys)SNV Uncertain significance 208900 rs863223374 X:7890096-7890096 X:7922055-7922055
22 TTN , TTN-AS1 NM_001267550.2(TTN):c.7961G>A (p.Arg2654Lys)SNV Likely benign 47461 rs147207100 2:179636093-179636093 2:178771366-178771366
23 FLNA NM_001110556.2(FLNA):c.7903G>A (p.Glu2635Lys)SNV Likely benign 208878 rs369717556 X:153577258-153577258 X:154348890-154348890
24 DMD NM_004006.2(DMD):c.8308G>A (p.Asp2770Asn)SNV Benign/Likely benign 201740 rs138399787 X:31525480-31525480 X:31507363-31507363
25 PHKA2 NM_000292.3(PHKA2):c.2951T>C (p.Ile984Thr)SNV Benign 208885 rs863223371 X:18919679-18919679 X:18901561-18901561
26 MBTPS2 NM_015884.4(MBTPS2):c.1013A>T (p.His338Leu)SNV Benign 208889 rs863223373 X:21896202-21896202 X:21878084-21878084
27 ZNF41 NM_007130.3(ZNF41):c.677A>T (p.His226Leu)SNV Benign 208875 rs368078047 X:47308492-47308492 X:47449093-47449093
28 FAM47A NM_203408.3(FAM47A):c.1310C>T (p.Thr437Met)SNV Benign 208903 rs373238471 X:34149086-34149086 X:34130969-34130969
29 AHNAK2 NM_138420.4(AHNAK2):c.5025G>C (p.Lys1675Asn)SNV Benign 208974 rs202246282 14:105416763-105416763 14:104950426-104950426
30 AHNAK2 NM_138420.4(AHNAK2):c.2695G>T (p.Val899Leu)SNV Benign 208975 rs199974920 14:105419093-105419093 14:104952756-104952756
31 PLA2G4E NM_001206670.1(PLA2G4E):c.1717A>G (p.Met573Val)SNV Benign 208869 rs863223366 15:42281619-42281619 15:41989421-41989421
32 LACTB NM_032857.5(LACTB):c.46G>C (p.Gly16Arg)SNV Benign 208871 rs34925488 15:63414116-63414116 15:63121917-63121917
33 ZSCAN2 NM_181877.4(ZSCAN2):c.152_153del (p.Pro51fs)deletion Benign 208861 rs863223360 15:85147310-85147311 15:84604079-84604080
34 ACSM2A NM_001308172.2(ACSM2A):c.72C>G (p.Tyr24Ter)SNV Benign 208931 rs142460751 16:20471508-20471508 16:20460186-20460186
35 ACSM2A NM_001308172.2(ACSM2A):c.1414C>T (p.Arg472Trp)SNV Benign 208932 rs755234990 16:20492148-20492148 16:20480826-20480826
36 AIPL1 NM_014336.5(AIPL1):c.1004C>A (p.Pro335His)SNV Benign 208866 rs863223363 17:6328931-6328931 17:6425611-6425611
37 EVPL NM_001988.4(EVPL):c.4126G>T (p.Val1376Leu)SNV Benign 208945 rs777067468 17:74005160-74005160 17:76009079-76009079
38 EVPL NM_001988.4(EVPL):c.314G>A (p.Arg105Gln)SNV Benign 208946 rs755302072 17:74019620-74019620 17:76023539-76023539
39 RFX1 NM_002918.5(RFX1):c.2695G>A (p.Gly899Ser)SNV Benign 208909 rs766888168 19:14073963-14073963 19:13963151-13963151
40 URI1 NM_001252641.2(URI1):c.33C>A (p.His11Gln)SNV Benign 208948 rs756055523 19:30414631-30414631 19:29923724-29923724
41 URI1 NM_003796.3(URI1):c.698C>T (p.Thr233Ile)SNV Benign 208949 rs863223392 19:30499923-30499923 19:30009016-30009016
42 PLEKHG2 NM_022835.3(PLEKHG2):c.1230C>A (p.Phe410Leu)SNV Benign 208934 rs863223387 19:39909610-39909610 19:39418970-39418970
43 PLEKHG2 NM_022835.3(PLEKHG2):c.4073T>C (p.Leu1358Ser)SNV Benign 208935 rs373442104 19:39915846-39915846 19:39425206-39425206
44 CLC NM_001828.6(CLC):c.389T>G (p.Ile130Ser)SNV Benign 208912 rs117361485 19:40222060-40222060 19:39731420-39731420
45 DYRK1B NM_004714.3(DYRK1B):c.625G>A (p.Val209Ile)SNV Benign 208913 rs556237495 19:40319119-40319119 19:39828479-39828479
46 MEIS3 NM_001301059.2(MEIS3):c.202C>A (p.Leu68Ile)SNV Benign 208914 rs140643747 19:47920204-47920204 19:47416947-47416947
47 PRR12 NM_020719.3(PRR12):c.4397_4398insCCCTCA (p.Gln1468_Pro1469insHisPro)insertion Benign 208868 rs863223365 19:50104799-50104800 19:49601542-49601543
48 MUC16 NM_024690.2(MUC16):c.26366C>T (p.Pro8789Leu)SNV Benign 208943 rs78804712 19:9061080-9061080 19:8950404-8950404
49 MUC16 NM_024690.2(MUC16):c.26180C>T (p.Ala8727Val)SNV Benign 208915 rs863223378 19:9061266-9061266 19:8950590-8950590
50 MUC16 NM_024690.2(MUC16):c.10300T>C (p.Ser3434Pro)SNV Benign 208916 rs863223379 19:9077146-9077146 19:8966470-8966470

Expression for Neuronal Migration Disorders

Search GEO for disease gene expression data for Neuronal Migration Disorders.

Pathways for Neuronal Migration Disorders

Pathways related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.03 SCN1A PAFAH1B1 DCX
2 11.75 VIM TUBA1A PAFAH1B1 DCX
3 10.72 RELN PAFAH1B1
4 10.6 PAFAH1B1 DYNC1H1
5 10.42 RELN PAFAH1B1 DYNC1H1 DCX

GO Terms for Neuronal Migration Disorders

Cellular components related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.56 VIM RELN PAFAH1B1 DCX
2 microtubule GO:0005874 9.46 TUBA1A PAFAH1B1 DYNC1H1 DCX
3 axon cytoplasm GO:1904115 9.4 PAFAH1B1 DYNC1H1
4 cell leading edge GO:0031252 9.37 VIM PAFAH1B1
5 microtubule associated complex GO:0005875 9.32 PAFAH1B1 DCX
6 cytoskeleton GO:0005856 9.17 WDR62 VIM TUBA1A PAFAH1B1 DYNC1H1 DCX
7 cytoplasmic microtubule GO:0005881 9.13 TUBA1A PAFAH1B1 DYNC1H1

Biological processes related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.81 WDR62 PAFAH1B1 DCX ADGRG1
2 cell migration GO:0016477 9.7 RELN PAFAH1B1 ADGRG1
3 G2/M transition of mitotic cell cycle GO:0000086 9.65 TUBA1A PAFAH1B1 DYNC1H1
4 neuron migration GO:0001764 9.61 RELN PAFAH1B1 DCX
5 mitotic spindle organization GO:0007052 9.55 WDR62 DYNC1H1
6 microtubule-based process GO:0007017 9.54 TUBA1A PAFAH1B1
7 ciliary basal body-plasma membrane docking GO:0097711 9.54 TUBA1A PAFAH1B1 DYNC1H1
8 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.5 TUBA1A PAFAH1B1 DYNC1H1
9 positive regulation of dendritic spine morphogenesis GO:0061003 9.49 RELN PAFAH1B1
10 nuclear migration GO:0007097 9.46 PAFAH1B1 DYNC1H1
11 cerebral cortex development GO:0021987 9.43 WDR62 RELN PAFAH1B1
12 retrograde axonal transport GO:0008090 9.4 PAFAH1B1 DYNC1H1
13 hippocampus development GO:0021766 9.33 RELN PAFAH1B1 DCX
14 brain development GO:0007420 9.26 RELN PAFAH1B1 DCX ADGRG1
15 layer formation in cerebral cortex GO:0021819 8.92 RELN PAFAH1B1 DCX ADGRG1

Molecular functions related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dynein intermediate chain binding GO:0045505 8.62 PAFAH1B1 DYNC1H1

Sources for Neuronal Migration Disorders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HMDB
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32 ICD10
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68 SNOMED-CT via HPO
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70 Tocris
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72 UMLS via Orphanet
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