MCID: NRN016
MIFTS: 38

Neuronal Migration Disorders

Categories: Neuronal diseases

Aliases & Classifications for Neuronal Migration Disorders

MalaCards integrated aliases for Neuronal Migration Disorders:

Name: Neuronal Migration Disorders 54
Abnormality of Neuronal Migration 29 6
Malformations of Cortical Development, Group Ii 73
Neuronal Migration Disorder 37

Classifications:



External Ids:

KEGG 37 H01835
UMLS 73 C1837249

Summaries for Neuronal Migration Disorders

NINDS : 54 Neuronal migration disorders (NMDs) are a group of birth defects caused by the abnormal migration of neurons in the developing brain and nervous system. In the developing brain, neurons must migrate from the areas where they are born to the areas where they will settle into their proper neural circuits. Neuronal migration, which occurs as early as the second month of gestation, is controlled by a complex assortment of chemical guides and signals. When these signals are absent or incorrect, neurons do not end up where they belong. This can result in structurally abnormal or missing areas of the brain in the cerebral hemispheres, cerebellum, brainstem, or hippocampus. The structural abnormalities found in NMDs include schizencephaly, porencephaly, lissencephaly, agyria, macrogyria, polymicrogyria, pachygyria, microgyria, micropolygyria, neuronal heterotopias (including band heterotopia), agenesis of the corpus callosum, and agenesis of the cranial nerves. Symptoms vary according to the abnormality, but often feature poor muscle tone and motor function, seizures, developmental delays, impaired cognitive development, failure to grow and thrive, difficulties with feeding, swelling in the extremities, and a smaller than normal head. Most infants with an NMD appear normal, but some disorders have characteristic facial or skull features that can be recognized by a neurologist. Several genetic abnormalities in children with NMDs have been identified. Defects in genes that are involved in neuronal migration have been associated with NMDs, but the role they play in the development of these disorders is not yet well-understood. More than 25 syndromes resulting from abnormal neuronal migration have been described. Among them are syndromes with several different patterns of inheritance; genetic counseling thus differs greatly between syndromes.

MalaCards based summary : Neuronal Migration Disorders, also known as abnormality of neuronal migration, is related to lissencephaly 1 and band heterotopia. An important gene associated with Neuronal Migration Disorders is DYNC1H1 (Dynein Cytoplasmic 1 Heavy Chain 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Reelin signaling pathway. The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and cortex, and related phenotypes are nervous system and reproductive system

Wikipedia : 76 Neuronal migration disorder (NMD) refers to a heterogenous group of disorders that, it is supposed,... more...

Related Diseases for Neuronal Migration Disorders

Diseases related to Neuronal Migration Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 lissencephaly 1 30.9 DCX PAFAH1B1 RELN
2 band heterotopia 29.4 DCX PAFAH1B1
3 periventricular nodular heterotopia 29.2 DCX PAFAH1B1 RELN
4 pachygyria 29.2 PAFAH1B1 WDR62
5 lissencephaly 29.0 DCX PAFAH1B1 RELN
6 flna-related periventricular nodular heterotopia 10.9
7 colpocephaly 10.9
8 pachygyria with mental retardation, seizures, and arachnoid cysts 10.9
9 neuronitis 10.6
10 chromosome 17p13.3, centromeric, duplication syndrome 10.3 DCX PAFAH1B1
11 epilepsy 10.2
12 lissencephaly, x-linked, 1 10.0 DCX PAFAH1B1
13 cerebritis 9.9
14 zellweger syndrome 9.8
15 muscular dystrophy 9.8
16 lissencephaly with cerebellar hypoplasia 9.8 DCX PAFAH1B1 RELN
17 schizophrenia 9.7
18 major depressive disorder 9.7
19 depression 9.7
20 bipolar disorder 9.7
21 external auditory canal, bilateral atresia of, with congenital vertical talus 9.7
22 polymicrogyria 9.7
23 microcephalic osteodysplastic primordial dwarfism, type i 9.7
24 walker-warburg syndrome 9.7
25 muscular dystrophy-dystroglycanopathy , type a, 1 9.7
26 pseudobulbar palsy 9.7
27 dwarfism 9.7
28 isolated growth hormone deficiency, type ia 9.7
29 knobloch syndrome 9.7
30 knobloch syndrome 1 9.7
31 dysembryoplastic neuroepithelial tumor 9.7
32 morning glory syndrome 9.7
33 turner syndrome 9.7
34 passos-bueno syndrome 9.7
35 dyslexia 9.7
36 rasmussen johnsen thomsen syndrome 9.7
37 movement disease 9.7
38 muscular dystrophy, congenital, lmna-related 9.7
39 skin tag 9.7
40 monosomy 21 9.7
41 corpus callosum, agenesis of, with facial anomalies and cerebellar ataxia 9.7
42 rasmussen subacute encephalitis 9.7
43 alobar holoprosencephaly 9.7
44 cerebral palsy 9.7
45 diabetes insipidus 9.7
46 holoprosencephaly 9.7
47 temporal lobe epilepsy 9.7
48 type i 9.7
49 tuberous sclerosis 9.4 DCX VIM
50 physical disorder 9.2 DCX PAFAH1B1 WDR62

Graphical network of the top 20 diseases related to Neuronal Migration Disorders:



Diseases related to Neuronal Migration Disorders

Symptoms & Phenotypes for Neuronal Migration Disorders

MGI Mouse Phenotypes related to Neuronal Migration Disorders:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.43 DCX DYNC1H1 PAFAH1B1 RELN VIM WDR62
2 reproductive system MP:0005389 9.1 DCX DYNC1H1 PAFAH1B1 RELN VIM WDR62

Drugs & Therapeutics for Neuronal Migration Disorders

Drugs for Neuronal Migration Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Levodopa Approved Phase 4 59-92-7 6047
3 Neurotransmitter Agents Phase 4
4 Dihydroxyphenylalanine Phase 4
5 Dopamine Agents Phase 4
6 Peripheral Nervous System Agents Phase 4
7 Protective Agents Phase 4
8 Autonomic Agents Phase 4
9 Carbidopa, levodopa drug combination Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
2 Human Epilepsy Genetics--Neuronal Migration Disorders Study Recruiting NCT00041600
3 Quality of Life Assessment Before and After Essure Removal Not yet recruiting NCT03401437

Search NIH Clinical Center for Neuronal Migration Disorders

Genetic Tests for Neuronal Migration Disorders

Genetic tests related to Neuronal Migration Disorders:

# Genetic test Affiliating Genes
1 Abnormality of Neuronal Migration 29

Anatomical Context for Neuronal Migration Disorders

MalaCards organs/tissues related to Neuronal Migration Disorders:

41
Brain, Cerebellum, Cortex, Temporal Lobe, Skin

Publications for Neuronal Migration Disorders

Articles related to Neuronal Migration Disorders:

(show top 50) (show all 87)
# Title Authors Year
1
Neuronal Migration Disorders. ( 29298944 )
2018
2
Germline and somatic mutations in cortical malformations: Molecular defects in Argentinean patients with neuronal migration disorders. ( 28953922 )
2017
3
Genotype-phenotype correlation in neuronal migration disorders and cortical dysplasias. ( 26052266 )
2015
4
Neuronal migration disorders: Focus on the cytoskeleton and epilepsy. ( 26299390 )
2015
5
The Relevance of Human Fetal Subplate Zone for Developmental Neuropathology of Neuronal Migration Disorders and Cortical Dysplasia. ( 25312583 )
2014
6
Rufinamide for the treatment of refractory epilepsy secondary to neuronal migration disorders. ( 24548548 )
2014
7
Embryonic disruption of the candidate dyslexia susceptibility gene homolog Kiaa0319-like results in neuronal migration disorders. ( 23831424 )
2013
8
Cytoskeleton in action: lissencephaly, a neuronal migration disorder. ( 23495356 )
2013
9
Neuronal migration disorders in microcephalic osteodysplastic primordial dwarfism type I/III. ( 20857301 )
2011
10
Molecular genetics of neuronal migration disorders. ( 21222180 )
2011
11
The beta-tubulin gene TUBB2B is involved in a large spectrum of neuronal migration disorders. ( 20101787 )
2010
12
Neuronal migration disorders. ( 19245832 )
2010
13
New trends in neuronal migration disorders. ( 19264520 )
2010
14
Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder. ( 19098909 )
2009
15
Neuronal migration disorders: clinical, neuroradiologic and genetics aspects. ( 19120042 )
2009
16
Movement disorder and neuronal migration disorder due to ARFGEF2 mutation. ( 19384555 )
2009
17
Experimental neuronal migration disorders following the administration of ibotenate in hamsters: the role of the subventricular zone in the development of cortical dysplasia. ( 19258286 )
2009
18
Neuronal migration disorders, agenesis of corpus callosum, preauricular skin tag and bilateral morning glory syndrome in a term newborn infant. ( 18388784 )
2008
19
Sudden death in a patient with mosaic ring X Turner syndrome and a neuronal migration disorder. ( 18049086 )
2008
20
N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. ( 17875668 )
2007
21
Grey matter heterotopia: what EEG-fMRI can tell us about epileptogenicity of neuronal migration disorders. ( 16339793 )
2006
22
Pattern of childhood epilepsies with neuronal migrational disorders in Oman. ( 17092459 )
2006
23
Reading impairment in the neuronal migration disorder of periventricular nodular heterotopia. ( 16434687 )
2006
24
Neurophysiologic findings of neuronal migration disorders: intrinsic epileptogenicity of focal cortical dysplasia on electroencephalography, electrocorticography, and magnetoencephalography. ( 15921239 )
2005
25
Are altered excitatory synapses found in neuronal migration disorders? ( 16175215 )
2005
26
Proceedings of the International Symposium on Neuronal Migration Disorders and Childhood Epilepsies: clinical manifestations, pathomechanisms, and etiopathogenesis. April 16-17, 2004. Tokyo, Japan. ( 16044620 )
2005
27
Neuronal migration disorders, genetics, and epileptogenesis. ( 15921228 )
2005
28
Neuronal migration disorders. ( 16417844 )
2005
29
Reading impairment in the neuronal migration disorder of periventricular nodular heterotopia. ( 15753412 )
2005
30
High molecular weight microtubule-associated protein 2 over-expression in neuronal migration disorders caused by N-methyl-D-aspartate receptor activation in hamsters. ( 15008898 )
2004
31
Radial and tangential neuronal migration disorder in ibotenate-induced cortical lesions in hamsters: immunohistochemical study of reelin, vimentin, and calretinin. ( 15072103 )
2004
32
Upregulation of glutamate receptors in rat cerebral cortex with neuronal migration disorders. ( 15201510 )
2004
33
Evidence of neuronal migration disorders in Knobloch syndrome: clinical and molecular analysis of two novel families. ( 12707952 )
2003
34
MRI and EEG findings in surgically treated patients with partial seizures due to neuronal migration disorders, their relations to each other and to surgery outcome. ( 14616299 )
2003
35
Density and distribution of white matter neurons in schizophrenia, bipolar disorder and major depressive disorder: no evidence for abnormalities of neuronal migration. ( 12140779 )
2002
36
Presumptive monosomy 21 with neuronal migration disorder re-diagnosed as de novo unbalanced translocation t(18p;21q) by fluorescence in situ hybridisation. ( 12150215 )
2002
37
Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker-Warburg syndrome. ( 12369018 )
2002
38
Various findings in surgically treated epilepsy patients with dysembryoplastic neuroepithelial tumors in comparison with those of patients with other low-grade brain tumors and other neuronal migration disorders. ( 12423388 )
2002
39
Lactate and other metabolic changes in neuronal migration disorders. ( 11240607 )
2001
40
Neuronal migration disorders. ( 11553932 )
2001
41
Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. ( 11709191 )
2001
42
Molecular mechanisms of neuronal migration disorders, quo vadis? ( 11899256 )
2001
43
Pathogenic significance of neuronal migration disorders in temporal lobe epilepsy. ( 11431720 )
2001
44
[Development and developmental disorders of the human brain. III. Neuronal migration disorders of the cerebrum]. ( 11268908 )
2001
45
A novel migration-related gene product, doublecortin, in neuronal migration disorder of fetuses and infants with Zellweger syndrome. ( 10963364 )
2000
46
Neuronal migration disorders in man. ( 11151046 )
2000
47
Characterization of neuronal migration disorders in neocortical structures: loss or preservation of inhibitory interneurons? ( 10897147 )
2000
48
Single cause, polymorphic neuronal migration disorders: an animal model. ( 11085292 )
2000
49
Neuronal migration disorders: from genetic diseases to developmental mechanisms. ( 10906798 )
2000
50
Immunohistochemical expression of doublecortin in the human cerebrum: comparison of normal development and neuronal migration disorders. ( 10773210 )
2000

Variations for Neuronal Migration Disorders

ClinVar genetic disease variations for Neuronal Migration Disorders:

6
(show top 50) (show all 232)
# Gene Variation Type Significance SNP ID Assembly Location
1 ASNS NM_133436.3(ASNS): c.1648C> T (p.Arg550Cys) single nucleotide variant Likely pathogenic rs398122974 GRCh37 Chromosome 7, 97481609: 97481609
2 ASNS NM_133436.3(ASNS): c.1648C> T (p.Arg550Cys) single nucleotide variant Likely pathogenic rs398122974 GRCh38 Chromosome 7, 97852297: 97852297
3 TUBA1A NM_006009.3(TUBA1A): c.1148C> T (p.Ala383Val) single nucleotide variant Likely pathogenic rs587784482 GRCh37 Chromosome 12, 49579001: 49579001
4 TUBA1A NM_006009.3(TUBA1A): c.1148C> T (p.Ala383Val) single nucleotide variant Likely pathogenic rs587784482 GRCh38 Chromosome 12, 49185218: 49185218
5 TTN NM_001267550.2(TTN): c.88972A> G (p.Ile29658Val) single nucleotide variant Conflicting interpretations of pathogenicity rs200193877 GRCh37 Chromosome 2, 179418866: 179418866
6 TTN NM_001267550.2(TTN): c.88972A> G (p.Ile29658Val) single nucleotide variant Conflicting interpretations of pathogenicity rs200193877 GRCh38 Chromosome 2, 178554139: 178554139
7 DMD NM_004013.2(DMD): c.928G> A (p.Asp310Asn) single nucleotide variant Conflicting interpretations of pathogenicity rs138399787 GRCh37 Chromosome X, 31525480: 31525480
8 DMD NM_004013.2(DMD): c.928G> A (p.Asp310Asn) single nucleotide variant Conflicting interpretations of pathogenicity rs138399787 GRCh38 Chromosome X, 31507363: 31507363
9 TTN NM_001267550.2(TTN): c.1051G> A (p.Val351Met) single nucleotide variant Uncertain significance rs772889673 GRCh37 Chromosome 2, 179659843: 179659843
10 TTN NM_001267550.2(TTN): c.1051G> A (p.Val351Met) single nucleotide variant Uncertain significance rs772889673 GRCh38 Chromosome 2, 178795116: 178795116
11 COL3A1 NM_000090.3(COL3A1): c.2110G> A (p.Glu704Lys) single nucleotide variant Uncertain significance rs863223362 GRCh38 Chromosome 2, 188999372: 188999372
12 COL3A1 NM_000090.3(COL3A1): c.2110G> A (p.Glu704Lys) single nucleotide variant Uncertain significance rs863223362 GRCh37 Chromosome 2, 189864098: 189864098
13 MROH2A NM_001287395.1(MROH2A): c.1961G> A (p.Arg654Gln) single nucleotide variant Benign rs863223390 GRCh38 Chromosome 2, 233805011: 233805011
14 MROH2A NM_001287395.1(MROH2A): c.1961G> A (p.Arg654Gln) single nucleotide variant Benign rs863223390 GRCh37 Chromosome 2, 234713657: 234713657
15 MROH2A NM_001287395.1(MROH2A): c.2844_2845insGG (p.Leu950Glyfs) insertion Benign rs863223391 GRCh37 Chromosome 2, 234723302: 234723303
16 MROH2A NM_001287395.1(MROH2A): c.2844_2845insGG (p.Leu950Glyfs) insertion Benign rs863223391 GRCh38 Chromosome 2, 233814656: 233814657
17 THADA NM_001271643.1(THADA): c.2468C> T (p.Ser823Leu) single nucleotide variant Benign rs201555818 GRCh38 Chromosome 2, 43556551: 43556551
18 THADA NM_001271643.1(THADA): c.2468C> T (p.Ser823Leu) single nucleotide variant Benign rs201555818 GRCh37 Chromosome 2, 43783690: 43783690
19 THADA NM_001271643.1(THADA): c.362G> A (p.Arg121His) single nucleotide variant Benign rs769958179 GRCh38 Chromosome 2, 43586943: 43586943
20 THADA NM_001271643.1(THADA): c.362G> A (p.Arg121His) single nucleotide variant Benign rs769958179 GRCh37 Chromosome 2, 43814082: 43814082
21 NXPE3 NM_001134456.1(NXPE3): c.452_459delTCAAGCTG (p.Leu151Profs) deletion Benign rs863223380 GRCh38 Chromosome 3, 101801593: 101801600
22 NXPE3 NM_001134456.1(NXPE3): c.452_459delTCAAGCTG (p.Leu151Profs) deletion Benign rs863223380 GRCh37 Chromosome 3, 101520437: 101520444
23 NXPE3 NM_001134456.1(NXPE3): c.462delG (p.Ala155Leufs) deletion Benign rs863223381 GRCh38 Chromosome 3, 101801603: 101801603
24 NXPE3 NM_001134456.1(NXPE3): c.462delG (p.Ala155Leufs) deletion Benign rs863223381 GRCh37 Chromosome 3, 101520447: 101520447
25 NXPE3 NM_001134456.1(NXPE3): c.956G> C (p.Gly319Ala) single nucleotide variant Benign rs140150886 GRCh38 Chromosome 3, 101816828: 101816828
26 NXPE3 NM_001134456.1(NXPE3): c.956G> C (p.Gly319Ala) single nucleotide variant Benign rs140150886 GRCh37 Chromosome 3, 101535672: 101535672
27 PARP14 NM_017554.2(PARP14): c.1455T> A (p.Ser485Arg) single nucleotide variant Benign rs863223384 GRCh38 Chromosome 3, 122700009: 122700009
28 PARP14 NM_017554.2(PARP14): c.1455T> A (p.Ser485Arg) single nucleotide variant Benign rs863223384 GRCh37 Chromosome 3, 122418856: 122418856
29 PARP14 NM_017554.2(PARP14): c.2083C> A (p.Pro695Thr) single nucleotide variant Benign rs863223385 GRCh38 Chromosome 3, 122700637: 122700637
30 PARP14 NM_017554.2(PARP14): c.2083C> A (p.Pro695Thr) single nucleotide variant Benign rs863223385 GRCh37 Chromosome 3, 122419484: 122419484
31 TNK2 NM_001010938.1(TNK2): c.1966G> A (p.Val656Met) single nucleotide variant Benign rs375205272 GRCh37 Chromosome 3, 195595392: 195595392
32 TNK2 NM_001010938.1(TNK2): c.1966G> A (p.Val656Met) single nucleotide variant Benign rs375205272 GRCh38 Chromosome 3, 195868521: 195868521
33 TNK2 NM_001010938.1(TNK2): c.955C> T (p.Arg319Cys) single nucleotide variant Benign rs767408627 GRCh37 Chromosome 3, 195609043: 195609043
34 TNK2 NM_001010938.1(TNK2): c.955C> T (p.Arg319Cys) single nucleotide variant Benign rs767408627 GRCh38 Chromosome 3, 195882172: 195882172
35 SCN10A NM_006514.3(SCN10A): c.2530C> T (p.Arg844Cys) single nucleotide variant no interpretation for the single variant rs140158387 GRCh37 Chromosome 3, 38770143: 38770143
36 SCN10A NM_006514.3(SCN10A): c.2530C> T (p.Arg844Cys) single nucleotide variant no interpretation for the single variant rs140158387 GRCh38 Chromosome 3, 38728652: 38728652
37 SCN10A NM_006514.3(SCN10A): c.597G> T (p.Leu199=) single nucleotide variant no interpretation for the single variant rs863223394 GRCh37 Chromosome 3, 38812772: 38812772
38 SCN10A NM_006514.3(SCN10A): c.597G> T (p.Leu199=) single nucleotide variant no interpretation for the single variant rs863223394 GRCh38 Chromosome 3, 38771281: 38771281
39 ATXN7 NM_001177387.1(ATXN7): c.211T> G (p.Ser71Ala) single nucleotide variant Benign rs201561286 GRCh38 Chromosome 3, 63912809: 63912809
40 ATXN7 NM_001177387.1(ATXN7): c.211T> G (p.Ser71Ala) single nucleotide variant Benign rs201561286 GRCh37 Chromosome 3, 63898485: 63898485
41 ATXN7 NM_001177387.1(ATXN7): c.844G> A (p.Val282Met) single nucleotide variant Benign rs863223393 GRCh38 Chromosome 3, 63982277: 63982277
42 ATXN7 NM_001177387.1(ATXN7): c.844G> A (p.Val282Met) single nucleotide variant Benign rs863223393 GRCh37 Chromosome 3, 63967953: 63967953
43 PI4K2B NM_018323.3(PI4K2B): c.10C> A (p.Pro4Thr) single nucleotide variant Benign rs863223383 GRCh38 Chromosome 4, 25234173: 25234173
44 PI4K2B NM_018323.3(PI4K2B): c.10C> A (p.Pro4Thr) single nucleotide variant Benign rs863223383 GRCh37 Chromosome 4, 25235795: 25235795
45 PI4K2B NM_018323.3(PI4K2B): c.861G> T (p.Gln287His) single nucleotide variant Benign rs143048917 GRCh38 Chromosome 4, 25259141: 25259141
46 PI4K2B NM_018323.3(PI4K2B): c.861G> T (p.Gln287His) single nucleotide variant Benign rs143048917 GRCh37 Chromosome 4, 25260763: 25260763
47 TLR6 NM_006068.4(TLR6): c.1729_1730delAT (p.Met577Valfs) deletion Benign rs863223364 GRCh37 Chromosome 4, 38829365: 38829366
48 TLR6 NM_006068.4(TLR6): c.1729_1730delAT (p.Met577Valfs) deletion Benign rs863223364 GRCh38 Chromosome 4, 38827744: 38827745
49 LRRC66 NM_001024611.2(LRRC66): c.1823delG (p.Gly608Alafs) deletion Benign rs863223368 GRCh38 Chromosome 4, 51995199: 51995199
50 LRRC66 NM_001024611.2(LRRC66): c.1823delG (p.Gly608Alafs) deletion Benign rs863223368 GRCh37 Chromosome 4, 52861365: 52861365

Expression for Neuronal Migration Disorders

Search GEO for disease gene expression data for Neuronal Migration Disorders.

Pathways for Neuronal Migration Disorders

Pathways related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.92 DCX PAFAH1B1 VIM
2 10.62 PAFAH1B1 RELN
3 10.42 DCX DYNC1H1 PAFAH1B1 RELN
4 10.4 DYNC1H1 PAFAH1B1

GO Terms for Neuronal Migration Disorders

Cellular components related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 centrosome GO:0005813 9.54 DYNC1H1 PAFAH1B1 WDR62
2 neuron projection GO:0043005 9.5 DCX PAFAH1B1 VIM
3 microtubule GO:0005874 9.43 DCX DYNC1H1 PAFAH1B1
4 cell leading edge GO:0031252 9.16 PAFAH1B1 VIM
5 cytoskeleton GO:0005856 9.02 DCX DYNC1H1 PAFAH1B1 VIM WDR62
6 microtubule associated complex GO:0005875 8.96 DCX PAFAH1B1

Biological processes related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.67 DCX PAFAH1B1 WDR62
2 brain development GO:0007420 9.54 DCX PAFAH1B1 RELN
3 sister chromatid cohesion GO:0007062 9.51 DYNC1H1 PAFAH1B1
4 ciliary basal body-plasma membrane docking GO:0097711 9.48 DYNC1H1 PAFAH1B1
5 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.46 DYNC1H1 PAFAH1B1
6 negative regulation of neuron projection development GO:0010977 9.43 PAFAH1B1 VIM
7 neuron migration GO:0001764 9.43 DCX PAFAH1B1 RELN
8 mitotic spindle organization GO:0007052 9.4 DYNC1H1 WDR62
9 cerebral cortex development GO:0021987 9.33 PAFAH1B1 RELN WDR62
10 positive regulation of dendritic spine morphogenesis GO:0061003 9.32 PAFAH1B1 RELN
11 hippocampus development GO:0021766 9.13 DCX PAFAH1B1 RELN
12 layer formation in cerebral cortex GO:0021819 8.8 DCX PAFAH1B1 RELN

Molecular functions related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dynein intermediate chain binding GO:0045505 8.62 DYNC1H1 PAFAH1B1

Sources for Neuronal Migration Disorders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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