Aliases & Classifications for Neuronitis

MalaCards integrated aliases for Neuronitis:

Name: Neuronitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8117
NCIt 50 C34847
UMLS 73 C0027881

Summaries for Neuronitis

Disease Ontology : 12 A central nervous system disease that is characterized by neuron inflammation.

MalaCards based summary : Neuronitis is related to myocarditis and celiac disease 1. An important gene associated with Neuronitis is MB (Myoglobin), and among its related pathways/superpathways is Apoptosis and Autophagy. The drugs Prednisolone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cortex.

Related Diseases for Neuronitis

Diseases related to Neuronitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1324)
# Related Disease Score Top Affiliating Genes
1 myocarditis 28.5 CD40LG MB
2 celiac disease 1 27.7 CD40LG TNFRSF10A
3 ceroid lipofuscinosis, neuronal, 1 12.5
4 ceroid lipofuscinosis, neuronal, 10 12.5
5 ceroid lipofuscinosis, neuronal, 3 12.4
6 ceroid lipofuscinosis, neuronal, 2 12.4
7 ceroid lipofuscinosis, neuronal, 5 12.4
8 ceroid lipofuscinosis, neuronal, 6 12.4
9 neuronal ceroid lipofuscinosis 12.4
10 ceroid lipofuscinosis, neuronal, 8, northern epilepsy variant 12.4
11 motor neuron disease 12.4
12 ceroid lipofuscinosis, neuronal, 7 12.4
13 ceroid lipofuscinosis, neuronal, 4a, autosomal recessive 12.3
14 ceroid lipofuscinosis, neuronal, 4b, autosomal dominant 12.3
15 ceroid lipofuscinosis, neuronal, 8 12.3
16 ceroid lipofuscinosis, neuronal, 13 12.3
17 adult neuronal ceroid lipofuscinosis 12.3
18 ceroid lipofuscinosis, neuronal, 11 12.2
19 neuronal intranuclear inclusion disease 12.2
20 neuronal migration disorders 12.2
21 madras motor neuron disease 12.2
22 ceroid lipofuscinosis, neuronal, 9 12.2
23 neuronal intestinal dysplasia 12.1
24 intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked 12.1
25 vestibular neuronitis 12.1
26 neuronal ceroid-lipofuscinoses 12.1
27 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 12.0
28 amyotrophic lateral sclerosis 1 12.0
29 survival motor neuron spinal muscular atrophy 12.0
30 neuronal intestinal dysplasia, type b 11.9
31 nodular neuronal heterotopia 11.9
32 charcot-marie-tooth disease, guadalajara neuronal type 11.7
33 neuropathy, hereditary sensorimotor, with upper motor neuron, visual pathway and autonomic disturbance 11.7
34 motor neuron disease with dementia and ophthalmoplegia 11.7
35 focal or multifocal malformations in neuronal migration 11.7
36 neuronal interstitial dysplasia 11.7
37 lateral sclerosis 11.7
38 pick disease of brain 11.7
39 amyotrophic lateral sclerosis 4, juvenile 11.7
40 mitochondrial dna depletion syndrome 4a 11.7
41 frontotemporal dementia 11.6
42 neuronopathy, distal hereditary motor, type viib 11.6
43 spinal muscular atrophy, distal, autosomal recessive, 4 11.5
44 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 11.5
45 alzheimer disease 11.5
46 epilepsy, progressive myoclonic, 3, with or without intracellular inclusions 11.4
47 spastic paraplegia 39, autosomal recessive 11.4
48 mental retardation, autosomal dominant 13 11.4
49 spinal muscular atrophy 11.4
50 cln4 disease 11.3

Graphical network of the top 20 diseases related to Neuronitis:



Diseases related to Neuronitis

Symptoms & Phenotypes for Neuronitis

Drugs & Therapeutics for Neuronitis

Drugs for Neuronitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4 Prednisolone acetate Phase 4,Phase 3
5 glucocorticoids Phase 4,Phase 3,Phase 2
6 Methylprednisolone acetate Phase 4,Phase 3
7 Methylprednisolone Hemisuccinate Phase 4,Phase 3
8 Gastrointestinal Agents Phase 4,Phase 3
9 Neuroprotective Agents Phase 4,Phase 3
10 Hormone Antagonists Phase 4,Phase 3,Phase 2
11 Hormones Phase 4,Phase 3,Phase 2
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
13 Peripheral Nervous System Agents Phase 4,Phase 3
14 Prednisolone hemisuccinate Phase 4,Phase 3
15 Prednisolone phosphate Phase 4,Phase 3
16 Antiemetics Phase 4,Phase 3
17 Protective Agents Phase 4,Phase 3
18 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
19 Autonomic Agents Phase 4,Phase 3
20 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
21 Betamethasone Valerate Phase 4 2152-44-5
22 Respiratory System Agents Phase 4,Phase 3
23 Anti-Asthmatic Agents Phase 4,Phase 3
24 Betamethasone benzoate Phase 4
25 Betamethasone sodium phosphate Phase 4
26 Betamethasone-17,21-dipropionate Phase 4
27
Cilostazol Approved, Investigational Phase 3 73963-72-1 2754
28 Fibrinolytic Agents Phase 3
29 Vasodilator Agents Phase 3
30 Phosphodiesterase 3 Inhibitors Phase 3
31 Phosphodiesterase Inhibitors Phase 3
32 Platelet Aggregation Inhibitors Phase 3
33 Bronchodilator Agents Phase 3
34 Ginkgo Nutraceutical Phase 3
35
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
36
Menthol Approved Early Phase 1,Not Applicable 2216-51-5 16666
37
Dexamethasone Approved, Investigational, Vet_approved Early Phase 1 50-02-2 5743
38 Dexamethasone acetate Early Phase 1 1177-87-3
39 BB 1101 Early Phase 1

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Recruiting NCT02912182 Phase 4 Betamethasone;Placebo;Prednisolone
2 The Efficacy of Steroid Therapy in Vestibular Neuritis Unknown status NCT02098330 Phase 3 Ginkgo biloba & Methylprednisolone;Ginkgo biloba
3 Effect of Renexin Tablet in Patients With Recurrent Vestibulopathy Terminated NCT01895400 Phase 3 Renexin (cilostazol 100mg + gingko biloba extract 80 mg);Placebo
4 Prednisone Treatment for Vestibular Neuronitis Completed NCT00271791 Phase 2 Prednisone;Prednisone
5 Complementary/Alternative Medicine for Abnormality in the Vestibular (Balance) System Completed NCT00032383 Phase 1, Phase 2
6 Characterisation of Cortical Vestibular Evoked Potentials (C-VEPs) Unknown status NCT02463695 Not Applicable
7 The Role of Corticosteroids and Vestibular Exercises in Recovery of Vestibular Neuritis Unknown status NCT01231009 Early Phase 1 Corticosteroids
8 Vestibular System in Migrainous Vertigo Patients Unknown status NCT00901953
9 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216 Not Applicable
10 Home-based Computer Gaming in Vestibular Rehabilitation Completed NCT01943955 Not Applicable
11 Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool Completed NCT02171312
12 MRIPositive Diagnosis of Vestibular Neuritis Using Fluid Attenuated Inversion Recuperation (FLAIR) Sequence on a 1.5 Tesla Recruiting NCT03452410
13 Assessment and Treatment of Patients With Long-term Dizziness in Primary Care Recruiting NCT02655575 Not Applicable
14 Vestibulopathy With Vestibulo Ocular Reflex (VOR) Gain Deficit Not yet recruiting NCT03271775 Not Applicable

Search NIH Clinical Center for Neuronitis

Genetic Tests for Neuronitis

Anatomical Context for Neuronitis

MalaCards organs/tissues related to Neuronitis:

41
Brain, Spinal Cord, Cortex, Lung, Dorsal Root Ganglion, Hypothalamus, Bone

Publications for Neuronitis

Articles related to Neuronitis:

(show top 50) (show all 19025)
# Title Authors Year
1
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated I+-tubulin defect which improves after iHDAC6 treatment in Rett syndrome. ( 29730163 )
2018
2
Downbeat nystagmus and lower motor neuron disease: 14A years follow-up. ( 29396677 )
2018
3
Characteristics of PPT1 and TPP1 enzymes in neuronal ceroid lipofuscinosis (NCL) 1 and 2 by dried blood spots (DBS) and leukocytes and their application to newborn screening. ( 29599076 )
2018
4
Motor neuron disease: Positive trial results published for ground-breaking SMA therapies. ( 29146955 )
2018
5
Short-Term Administration of Mycophenolate Is Well-Tolerated in CLN3 Disease (Juvenile Neuronal Ceroid Lipofuscinosis). ( 29923092 )
2018
6
Identification of two novel null variants in CLN8 by targeted next-generation sequencing: first report of a Chinese patient with neuronal ceroid lipofuscinosis due to CLN8 variants. ( 29422019 )
2018
7
Retinal Neuronal Loss in Visually Asymptomatic Patients With Myoclonic Epilepsy With Ragged-Red Fibers. ( 29979334 )
2018
8
High-efficiency transduction of spinal cord motor neurons by intrauterine delivery of integration-deficient lentiviral vectors. ( 29289570 )
2018
9
Late-onset childhood neuronal ceroid lipofuscinosis: Early clinical and electroencephalographic markers. ( 29778029 )
2018
10
Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. ( 29725084 )
2018
11
IL-18 Contributes to Bone Cancer Pain by Regulating Glia Cells and Neuron Interaction. ( 29079540 )
2018
12
Loss of Angelman Syndrome Protein E6AP Disrupts a Novel Antagonistic Estrogen-Retinoic Acid Transcriptional Crosstalk in Neurons. ( 29388081 )
2018
13
Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia. ( 29339464 )
2018
14
Tremor in motor neuron disease may be central rather than peripheral in origin. ( 29953699 )
2018
15
Global and Widespread Local White Matter Abnormalities in Juvenile Neuronal Ceroid Lipofuscinosis. ( 29853519 )
2018
16
Self-Regulation and Executive Functioning as Related to Survival in Motor Neuron Disease: Preliminary Findings. ( 29771729 )
2018
17
Imaging muscle as a potential biomarker of denervation in motor neuron disease. ( 29089397 )
2018
18
Neuronal Migration Disorders. ( 29298944 )
2018
19
FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury. ( 29315225 )
2018
20
Activation of Sigma-1 Receptor by Cutamesine Attenuates Neuronal Apoptosis by Inhibiting Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in a Rat Model of Asphyxia Cardiac Arrest. ( 29424796 )
2018
21
Being Yourself and Thinking About the Future in People With Motor Neuron Disease: A Grounded Theory of Self-care Processes. ( 29652734 )
2018
22
Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease. ( 29760195 )
2018
23
Motor neuron disease in patients with HIV infection: Report of two cases and brief review of the literature. ( 29909186 )
2018
24
Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis. ( 29378861 )
2018
25
Age-dependent sex ratios of motor neuron disease: French nationwide study and meta-analysis. ( 29602909 )
2018
26
GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons. ( 28696429 )
2018
27
Motor neuron disease in sub-Saharan Africa: case series from a Tanzanian referral hospital. ( 29549191 )
2018
28
Hyperekplexia-associated mutations in the neuronal glycine transporter 2. ( 29859229 )
2018
29
A homozygous I684T in GLE1 as a novel cause of arthrogryposis and motor neuron loss. ( 28657126 )
2018
30
MRI findings of neuronal ceroid lipofuscinosis in a cat. ( 29531776 )
2018
31
Path perturbation detection tasks reduce MSTd neuronal self-movement heading responses. ( 29046430 )
2018
32
Treatment with low doses of aspirin during chronic phase of experimental Chagas' disease increases oesophageal nitrergic neuronal subpopulation in mice. ( 29349896 )
2018
33
Spinal PKC activation - Induced neuronal HMGB1 translocation contributes to hyperalgesia in a bone cancer pain model in rats. ( 29428215 )
2018
34
An autopsy case of globular glial tauopathy presenting with clinical features of motor neuron disease with dementia and iron deposition in the motor cortex. ( 29508434 )
2018
35
The Protective effect of P7C3 against DNA and neuron damage in rat pups with congenital hypothyroidism. ( 29665652 )
2018
36
Acamprosate rescues neuronal defects in the Drosophila model of Fragile X Syndrome. ( 29317220 )
2018
37
Pharmaco-genetic therapeutics targeting parvalbumin neurons attenuate temporal lobe epilepsy. ( 29894753 )
2018
38
ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma. ( 29941555 )
2018
39
Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome. ( 29908963 )
2018
40
<i>Panax ginseng</i> extract attenuates neuronal injury and cognitive deficits in rats with vascular dementia induced by chronic cerebral hypoperfusion. ( 29722318 )
2018
41
Correlation between bulbar functionality and laryngeal penetration and/or laryngotracheal aspiration on motor neuron disease. ( 29513871 )
2018
42
Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila. ( 29357349 )
2018
43
Inducible transgenic expression of tripeptidyl peptidase 1 in a mouse model of late-infantile neuronal ceroid lipofuscinosis. ( 29408933 )
2018
44
A case of neuronal intranuclear inclusion disease associated with lupus nephritis-like nephropathy. ( 29430526 )
2018
45
Neuronal loss and gliosis in the rat striatum subjected to 15 and 30 minutes of middle cerebral artery occlusion. ( 29354885 )
2018
46
Neuronal noise as an origin of sleep arousals and its role in sudden infant death syndrome. ( 29707639 )
2018
47
The Effects of De-Whiskering and Congenital Hypothyroidism on The Development of Nitrergic Neurons in Rat Primary Somatosensory and Motor Cortices. ( 29633592 )
2018
48
Motor neuron disease mortality rates in New Zealand 1992-2013. ( 29382218 )
2018
49
Serum neuron specific enolase may be a marker to predict the severity and outcome of cerebral venous thrombosis. ( 29128928 )
2018
50
Gene Therapy Approaches to Treat the Neurodegeneration and Visual Failure in Neuronal Ceroid Lipofuscinoses. ( 29721932 )
2018

Variations for Neuronitis

Expression for Neuronitis

Search GEO for disease gene expression data for Neuronitis.

Pathways for Neuronitis

Pathways related to Neuronitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.89 CD40LG TNFRSF10A

GO Terms for Neuronitis

Biological processes related to Neuronitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 8.96 CD40LG TNFRSF10A
2 tumor necrosis factor-mediated signaling pathway GO:0033209 8.62 CD40LG TNFRSF10A

Sources for Neuronitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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