Neuropathy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: NRP001 MIFTS: 58	Neuropathy Categories: Immune diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Neuropathy

MalaCards integrated aliases for Neuropathy:

Name: Neuropathy ¹¹ ¹⁴ ³⁸ ¹⁶ ⁷¹ ⁷⁵

Peripheral Neuropathy ¹¹ ⁷¹

Peripheral Neuropathies ¹⁴

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the nervous system

Polyneuropathies and other disorders of the peripheral nervous system

Other polyneuropathies

Polyneuropathy, unspecified

ICD11: ³³

Diseases of the nervous system

Nutritional or toxic disorders of the nervous system

Neurological disorders due to nutrient deficiency

Neuropathy due to nutritional deficiency

Neurological disorders due to toxicity

Neuropathy due to toxicity

Neuropathy due to toxicity, unspecified

Other specified neuropathy due to toxicity

External Ids:

Disease Ontology ¹¹ DOID:870

NCIt ⁴⁹ C4731

SNOMED-CT ⁶⁸ 42658009

ICD10 ³¹ G62.9

EFO ¹⁶ EFO_0004149

ICD11 ³³ 1851919630 1851919630/other 1851919630/unspecified more

UMLS ⁷¹ C0031117 C0442874

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Summaries for Neuropathy

Disease Ontology: ¹¹ A nervous system disease that is located in nerves or nerve cells.

MalaCards based summary: Neuropathy, also known as peripheral neuropathy, is related to neuropathy, hereditary, with liability to pressure palsies and neuropathy, hereditary sensory and autonomic, type iia, and has symptoms including tremor, back pain and headache. An important gene associated with Neuropathy is DLX6-AS1 (DLX6 Antisense RNA 1), and among its related pathways/superpathways are Neural crest differentiation and EGR2 and SOX10-mediated initiation of Schwann cell myelination. The drugs Bevacizumab and Carbidopa have been mentioned in the context of this disorder. Affiliated tissues include nerves, dorsal root ganglion and bone marrow, and related phenotypes are nervous system and growth/size/body region

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Related Diseases for Neuropathy

Diseases in the Neuropathy family:

Autoimmune Neuropathy

Hereditary Neuropathies

Diseases related to Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 3240)

#	Related Disease	Score	Top Affiliating Genes
1	neuropathy, hereditary, with liability to pressure palsies	33.4	PRX PMP22 MTMR2 MPZ MFN2 GJB1
2	neuropathy, hereditary sensory and autonomic, type iia	33.3	WNK1 SPTLC1 SLC12A6 POLG NGF MFN2
3	peripheral nervous system disease	33.3	SPTLC1 SLC12A6 PRX POLG PNPLA6 PMP22
4	leber hereditary optic neuropathy, modifier of	33.2	POLG MT-ND6 MT-ND4 MFN2
5	neuromyotonia and axonal neuropathy, autosomal recessive	33.2	MPZ MFN2 GJB1
6	neuropathy, congenital hypomyelinating, 1, autosomal recessive	33.2	SLC12A6 PRX PMP22 MTMR2 MPZ MFN2
7	diabetic neuropathy	33.2	PMP22 NGF MPZ
8	neuropathy, ataxia, and retinitis pigmentosa	33.1	POLG MT-ND6 MT-ND4
9	hereditary sensory neuropathy	33.1	WNK1 SPTLC1 NGF MPZ GDAP1
10	neuropathy, hereditary sensory and autonomic, type v	33.1	WNK1 SPTLC1 NGF
11	sensory peripheral neuropathy	33.1	SPTLC1 SLC12A6 PRX POLG PMP22 NGF
12	hypertrophic neuropathy of dejerine-sottas	33.1	PRX PMP22 MTMR2 MPZ MFN2 GJB1
13	optic nerve disease	33.0	POLG NGF MT-ND6 MT-ND4 MFN2 GDAP1
14	autonomic neuropathy	33.0	WNK1 SPTLC1 NGF
15	charcot-marie-tooth disease, axonal, type 2e	33.0	SPTLC1 PRX PMP22 NGF MTMR2 MPZ
16	neuronopathy, distal hereditary motor, type va	33.0	MPZ MFN2 GDAP1
17	neuropathy, hereditary sensory and autonomic, type ic	33.0	SPTLC1 MPZ GJB1
18	charcot-marie-tooth disease, x-linked dominant, 1	33.0	SPTLC1 PMP22 MTMR2 MPZ MFN2 GJB1
19	charcot-marie-tooth disease and deafness	33.0	SPTLC1 PRX PMP22 MTMR2 MPZ MFN2
20	hereditary neuropathies	32.9	PRX PMP22 MTMR2 MPZ MFN2 GJB1
21	neuropathy, hereditary sensory and autonomic, type ia	32.9	WNK1 SPTLC1
22	charcot-marie-tooth disease, demyelinating, type 1b	32.9	PRX PMP22 MTMR2 MPZ MFN2 GJB1
23	charcot-marie-tooth disease, demyelinating, type 1a	32.8	SPTLC1 PRX PMP22 MTMR2 MPZ MFN2
24	charcot-marie-tooth disease, axonal, type 2b	32.8	SPTLC1 MTMR2 MPZ MFN2 GJB1 GDAP1
25	hereditary motor and sensory neuropathy, type iic	32.8	MTMR2 MPZ MFN2 GJB1 GDAP1
26	peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	32.8	PMP22 MPZ GJB1 EGR2
27	ulnar neuropathy	32.8	PMP22 MPZ
28	neuropathy, hereditary motor and sensory, russe type	32.8	MTMR2 GDAP1
29	charcot-marie-tooth disease, type 4d	32.8	MTMR2 MPZ GJB1 GDAP1 EGR2
30	charcot-marie-tooth disease, demyelinating, type 1c	32.8	PRX PMP22 MTMR2 MPZ GJB1 GDAP1
31	deafness, x-linked 5, with peripheral neuropathy	32.8	DIAPH3 AIFM1
32	charcot-marie-tooth disease, axonal, type 2a1	32.8	MPZ MFN2 GDAP1
33	auditory neuropathy, autosomal dominant 1	32.8	DIAPH3 AIFM1
34	charcot-marie-tooth disease, dominant intermediate b	32.7	MTMR2 MPZ GJB1 GDAP1
35	charcot-marie-tooth disease, demyelinating, type 1f	32.7	PMP22 MTMR2 MPZ GJB1
36	nerve compression syndrome	32.7	PMP22 NGF MPZ
37	motor peripheral neuropathy	32.7	SLC12A6 PMP22 MFN2
38	charcot-marie-tooth disease	32.7	SPTLC1 SLC12A6 PRX POLG PMP22 NGF
39	agenesis of the corpus callosum with peripheral neuropathy	32.7	WNK1 SLC12A6
40	hereditary optic neuropathy	32.7	MT-ND6 MT-ND4
41	charcot-marie-tooth disease, axonal, type 2p	32.7	MPZ GDAP1 GAN
42	axonal neuropathy	32.7	POLG MFN2 GDAP1 GAN AIFM1
43	charcot-marie-tooth disease, type 4a	32.7	PRX MTMR2 MPZ MFN2 GJB1 GDAP1
44	charcot-marie-tooth disease, axonal, type 2d	32.7	MPZ MFN2 GJB1 GDAP1
45	charcot-marie-tooth disease, type 4b2	32.7	PRX MTMR2 MPZ MFN2 GJB1 GDAP1
46	charcot-marie-tooth disease, recessive intermediate a	32.7	MFN2 GJB1 GDAP1
47	charcot-marie-tooth disease type 2a2b	32.7	MTMR2 MPZ MFN2 GDAP1
48	polyneuropathy	32.7	PRX POLG PNPLA6 PMP22 NGF MPZ
49	charcot-marie-tooth disease, type 4b1	32.6	PRX MTMR2 MPZ GDAP1
50	charcot-marie-tooth disease, axonal, type 2f	32.6	MTMR2 MPZ MFN2 GJB1 GDAP1

Graphical network of the top 20 diseases related to Neuropathy:

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Symptoms & Phenotypes for Neuropathy

UMLS symptoms related to Neuropathy:

tremor; back pain; headache; syncope; hemiparesis; pain; chronic pain; sciatica; seizures; vertigo/dizziness; sleeplessness; neuralgia; neurologic symptoms; atypical facial pain

GenomeRNAi Phenotypes related to Neuropathy according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.13	AIFM1 DIAPH3 EGR2 GAN GDAP1 GJB1
2	no effect	GR00402-S-2	10.13	AIFM1 DIAPH3 EGR2 GAN GDAP1 MFN2

MGI Mouse Phenotypes related to Neuropathy:

⁴⁵ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.46	AIFM1 DLX6-AS1 EGR2 GAN GDAP1 GJB1
2	growth/size/body region	MP:0005378	10.36	AIFM1 DIAPH3 EGR2 GAN GJB1 MFN2
3	homeostasis/metabolism	MP:0005376	10.32	AIFM1 DIAPH3 EGR2 GDAP1 GJB1 MFN2
4	cellular	MP:0005384	10.22	AIFM1 DIAPH3 EGR2 GAN GDAP1 GJB1
5	behavior/neurological	MP:0005386	10.2	AIFM1 DIAPH3 EGR2 GAN GDAP1 GJB1
6	muscle	MP:0005369	10.15	AIFM1 GAN MFN2 MT-ND6 NGF PMP22
7	cardiovascular system	MP:0005385	10.07	AIFM1 DIAPH3 EGR2 MFN2 MT-ND6 NGF
8	embryo	MP:0005380	10.03	AIFM1 DIAPH3 EGR2 MFN2 PNPLA6 POLG
9	reproductive system	MP:0005389	9.96	EGR2 GDAP1 MFN2 MPZ MTMR2 MT-ND6
10	vision/eye	MP:0005391	9.81	AIFM1 DIAPH3 EGR2 GJB1 MT-ND6 NGF
11	mortality/aging	MP:0010768	9.8	AIFM1 DIAPH3 EGR2 GAN GJB1 MFN2
12	integument	MP:0010771	9.28	AIFM1 DIAPH3 EGR2 GDAP1 MPZ NGF

Sources

Drugs & Therapeutics for Neuropathy

Drugs for Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 492)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bevacizumab

Approved, Investigational

Phase 4

216974-75-3

135329020

Carbidopa

Approved

Phase 4

28860-95-9

34359 38101

Levodopa

Approved

Phase 4

59-92-7, 63-84-3

6047

Dalfampridine

Approved

Phase 4

504-24-5

1727

Mexiletine

Approved, Investigational

Phase 4

5370-01-4, 31828-71-4

4178

Sodium citrate

Approved, Investigational

Phase 4

68-04-2

23431961

Histamine

Approved, Investigational

Phase 4

51-45-6

774

Amitriptyline

Approved

Phase 4

50-48-6

2160

Nortriptyline

Approved

Phase 4

72-69-5

4543

Quinapril

Approved, Investigational

Phase 4

82586-55-8, 85441-61-8

54892

Nabilone

Approved, Investigational

Phase 4

51022-71-0

39860 5284592

Naloxone

Approved, Vet_approved

Phase 4

465-65-6

5284596

Carbamazepine

Approved, Investigational

Phase 4

298-46-4

2554

Dapagliflozin

Approved

Phase 4

461432-26-8

9887712

Bromocriptine

Approved, Investigational, Withdrawn

Phase 4

25614-03-3

31101

Cetirizine

Approved

Phase 4

83881-51-0

2678

Lacosamide

Approved

Phase 4

175481-36-4

21634109 219078

Mecobalamin

Approved, Investigational

Phase 4

13422-55-4

Hydroxocobalamin

Approved

Phase 4

13422-51-0

15589840 44475014

Acetylsalicylic acid

Approved, Vet_approved

Phase 4

50-78-2

2244

Memantine

Approved, Investigational

Phase 4

41100-52-1, 19982-08-2

4054

Lamotrigine

Approved, Investigational

Phase 4

84057-84-1

3878

Topiramate

Approved

Phase 4

97240-79-4

5284627

Rotigotine

Approved

Phase 4

99755-59-6, 92206-54-7

57537 59227

Valproic acid

Approved, Investigational

Phase 4

99-66-1

3121

Rizatriptan

Approved

Phase 4

145202-66-0, 144034-80-0

5078

Rivastigmine

Approved, Investigational

Phase 4

123441-03-2

77991

Levetiracetam

Approved

Phase 4

102767-28-2

441341 5284583

Pramipexole

Approved, Investigational

Phase 4

104632-26-0, 104632-25-9, 104632-28-2

4885 119570 59868

Zolmitriptan

Approved, Investigational

Phase 4

139264-17-8

60857

Sumatriptan

Approved, Investigational

Phase 4

103628-46-2

5358

Clopidogrel

Approved

Phase 4

120202-66-6, 113665-84-2

60606

Propranolol

Approved, Investigational

Phase 4

318-98-9, 525-66-6

62882 4946

Gabapentin

Approved, Investigational

Phase 4

60142-96-3

3446

Duloxetine

Approved

Phase 4

136434-34-9, 116539-59-4

60835

Dopamine

Approved

Phase 4

62-31-7, 51-61-6

681

Pregabalin

Approved, Investigational

Phase 4

148553-50-8

5486971

Norepinephrine

Approved

Phase 4

51-41-2

439260

Sildenafil

Approved, Investigational

Phase 4

139755-83-2, 171599-83-0

5212 135398744

Tadalafil

Approved, Investigational

Phase 4

171596-29-5

110635

Tapentadol

Approved

Phase 4

175591-23-8

9838022

Donepezil

Approved

Phase 4

120014-06-4

3152

Oxycodone

Approved, Illicit, Investigational

Phase 4

76-42-6

5284603

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 4

59-30-3

6037

Lipoic acid

Approved, Investigational, Nutraceutical

Phase 4

1200-22-2

864 6112

Citric acid

Approved, Nutraceutical, Vet_approved

Phase 4

77-92-9

311

Pyridoxine

Approved, Investigational, Nutraceutical, Vet_approved

Phase 4

65-23-6

1054

Cyanocobalamin

Approved, Nutraceutical

Phase 4

68-19-9

24892734 16212801 44176380

Cysteine

Approved, Nutraceutical

Phase 4

52-90-4

594 5862

Cobalamin

Experimental

Phase 4

13408-78-1

6857388

Interventional clinical trials:

(show top 50) (show all 1369)

#	Name	Status	NCT ID	Phase	Drugs
1	Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy. Multi-Center, Randomized Placebo Controlled Trial	Unknown status	NCT00123136	Phase 4
2	The Effects of Omega-3 Fatty Acids on Chemotherapy-induced Neuropathy and Inflammation in Patients With Breast Cancer	Unknown status	NCT01049295	Phase 4
3	Evaluation of the Impact of Subject and Staff Training on the Pregabalin vs. Placebo Difference in Subjects With Painful Diabetic Neuropathy (PDN)	Unknown status	NCT01770964	Phase 4	Pregabalin;placebo
4	Inspiratory Muscle Training in Patients With Autonomic Neuropathic: a Randomized Trial	Unknown status	NCT00752440	Phase 4
5	Treatment With Gamunex 10% Intravenous Immunoglobulin (IVIg) for Patients With Demyelination and Diabetes Mellitus: A Blinded, Placebo-Controlled Crossover Pilot Study	Unknown status	NCT02372149	Phase 4	10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
6	A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions	Completed	NCT00904202	Phase 4	Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
7	The Association of Alpha Lipoic Acid to the Median Nerve Decompression in the Carpal Tunnel Syndrome: a Randomized Controlled Trial.	Completed	NCT01895621	Phase 4
8	Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) : Pattern Electroretinography Study	Completed	NCT03046693	Phase 4	Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
9	Phase 4 Study of Evaluation of Neural Conduction Along the Visual Pathways Before and After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases	Completed	NCT00404729	Phase 4	Citicoline
10	Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy	Completed	NCT00432393	Phase 4	levodopa-carbidopa
11	Dalfampridine Treatment for Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)	Completed	NCT01975324	Phase 4	dalfampridine;Placebo
12	A 24 Week, Double-blind, Placebo-controlled, Multisite Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN)	Completed	NCT00726713	Phase 4
13	Comparison of the Effectiveness and Safety Between Tramadol 37.5 Mg/Acetaminophen 325mg And Gabapentin for The Treatment of Painful Diabetic Neuropathy: Multicenter, Randomized, Open Comparative Study	Completed	NCT00634543	Phase 4	Tramadol hydrochloride/ Acetaminophen;Gabapentin
14	A Prospective, Open Label, Multi-Center, Study Of Pregabalin In The Treatment Of Neuropathic Pain Associated With Diabetic Peripheral Neuropathy, Postherpetic Neuralgia, HIV-Related Peripheral Neuropathic Pain And Chemotherapy Induced Peripheral Neuropathic Pain	Completed	NCT00407511	Phase 4	Pregabalin
15	A 12-week, Multi-center, Randomized, Double-blind, Double Dummy, Parallel Clinical Trial to Compare the Efficacy of γ-linolenic Acid and Thioctic Acid in Patients With Diabetic Neuropathy	Completed	NCT03914404	Phase 4	γ-linoleic acid and placebo(Thioctic Acid);Thioctic Acid and placebo(γ-linoleic acid)
16	Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS)	Completed	NCT02260388	Phase 4	Nortriptyline;Duloxetine;Pregabalin;Mexiletine
17	Efficacy of Administration of Angiotensin Converting Enzyme Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus	Completed	NCT03031834	Phase 4	Quinapril
18	A Multicenter Trial Evaluating the Efficacy of Cesamet™ for the Symptomatic Treatment of Pain in Patients With Diabetic Peripheral Neuropathy	Completed	NCT00380913	Phase 4	Cesamet™ (nabilone)
19	High-dose Vitamin D Supplementation Reduces Inflammation and Improves Microcirculation in Patients With Diabetic Peripheral Neuropathy	Completed	NCT04377399	Phase 4	Vitamin D
20	External Natural History Controlled, Open-Label Intervention Study to Assess the Efficacy and Safety of Long-Term Treatment With Raxone® in Leber's Hereditary Optic Neuropathy (LHON)	Completed	NCT02774005	Phase 4	Idebenone
21	Clinical Study for Assessment of the Efficacy of Gabapentin (Carbatin and Neurontin) in Patients With Neuropathy Pain	Completed	NCT02074267	Phase 4	Carbatin;Neurontin
22	The Effect of α-lipoic Acid Treatment in Patient With Cardiac Autonomic Neuropathy by Comparing the Change of HRV Index & ANS Function:A 6month Multicenter, Randomized, Open Label Clinical Trial CANON Study	Completed	NCT02056366	Phase 4	α-lipoic acid
23	An Open, Multicenter Study on the Efficacy, Safety and Tolerability of Gabapentin, Titrated for Reaching an Effect for the Treatment of the Painful Diabetic Neuropathy	Completed	NCT00644748	Phase 4	gabapentin
24	A 13 Week, Double-Blind, Placebo-Controlled Phase 4 Trial of Pregabalin (CI-1008, 600 mg/Day) for Relief of Pain in Subjects With Painful Diabetic Peripheral Neuropathy	Completed	NCT00159679	Phase 4	Pregabalin
25	A 14-Week, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study To Evaluate The Safety And Efficacy Of Pregabalin (150mg-600mg/Day) Using A Flexible Optimal Dose Schedule In Patients With Painful Diabetic Peripheral Neuropathy (DPN).	Completed	NCT00156078	Phase 4	pregabalin
26	A Randomized, Double-Blind, Placebo-Controlled, Single Center Study Designed to Assess the Effects of Pregabalin on Change in Patients With Diabetic Neuropathy	Completed	NCT00573261	Phase 4	Pregabalin;Placebo
27	Long Term, Double Blind, Randomized, Placebo Controlled Multi-center Study of FRE.M.S.- Frequency Modulated Neural Stimulation Lorenz Therapy™ in Symptomatic Diabetic Neuropathy	Completed	NCT01628627	Phase 4
28	An Open Label Extension Safety Trial of Pregabalin (CI-1008) in Subjects With Diabetic Peripheral Neuropathy	Completed	NCT00159731	Phase 4	Pregabalin
29	A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy Who Need Opioid Combination Treatment With Existing Pregabalin Treatment	Completed	NCT01675531	Phase 4	Targin
30	A Prospective, Open-Label, Multicenter Study of the Effectiveness And Safety Of Lidoderm® As Add-On Treatment in Patients With Postherpetic Neuralgia, Diabetic Neuropathy, or Low Back Pain	Completed	NCT00904020	Phase 4	Lidoderm
31	A Prospective, Open-label Trial of Lidoderm® (Lidocaine Patch 5%)in Painful Diabetic and Idiopathic Neuropathy.	Completed	NCT00903851	Phase 4	Lidoderm
32	Efficacy and Safety of Pregabalin in an Open-label, Non-comparative, Flexible-dose Trial With Diabetic Peripheral Neuropathy or Postherpetic Neuralgia	Completed	NCT00629681	Phase 4	Pregabalin
33	Phase IV Open Non Comparative Trial to Evaluate Efficacy and Safety of Tegretol® in Diabetes Neuropathy Pain.	Completed	NCT01089855	Phase 4	Carbamazepine
34	A Comparative Study Of Botulinum Toxin Type A Versus Conventional Oral Therapy As A Second Line Treatment Of Diabetic Neuropathy	Completed	NCT05296759	Phase 4	botulinum toxin A;Gabapentin;Duloxetine
35	A Randomized, Double Blind, Placebo Controlled Prospective Study to Evaluate the Effectiveness of Monochromatic Infrared Photo Energy to Improve Diabetic Sensory Neuropathy	Completed	NCT00120341	Phase 4
36	A Phase IV Clinical Trial. Effect of Pulsing Electromagnetic Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study	Completed	NCT00614341	Phase 4
37	Neuroprotective Effect of Vitamin B12 and Vitamin B6 Against Vincristine Induced Peripheral Neuropathy: A Randomized, Double Blind, Placebo Controlled, Multi Center Trial	Completed	NCT02923388	Phase 4	Injection Mecobalamin,;Tablet Pyridoxine hydrochloride;Intravenous normal saline 1 ml;Placebo pill
38	Comparative Evaluation of Standard Wearing Shoes With Rocker Sole Shoes in Diabetic Patients With Neuropathy	Completed	NCT02891928	Phase 4
39	A Randomized, Single-dose, Parallel-group Study to Evaluate the Pharmacokinetic Profiles of Two Formulation of Pregabalin in Healthy Volunteers Under Fasting Conditions	Completed	NCT03712475	Phase 4	Pregabalin
40	Impact of Timed Bromocriptine-QR Therapy Upon Measures of Sympathetic Tone and Vascular Biology in Type 2 Diabetes Subjects	Completed	NCT02682901	Phase 4	Cycloset;Placebo
41	The Efficacy and Safety Profile of Capsaicin 8% Patch Versus 5% Lidocaine Patch in Patients With Diabetic Peripheral Neuropathic Pain: a Randomized, Placebo-controlled Study of South Asian Male Patients	Completed	NCT04238208	Phase 4	Lidocaine 5% patch;Capsaicin 8% Patch, Per 10 Square Centimeters
42	PRELIMINARY EVALUATION OF RETINAL EFFECTS OF PHARMACOLOLOGICAL LOWERING OF SERUM LEVES OF ADVANCED GLYCATION END-PRODUCTS (AGEs) IN TYPE 2 DIABETIC PATIENTS	Completed	NCT02249897	Phase 4	CHOLESTYRAMINE
43	An Open-Label, Randomized Comparison of Duloxetine, Pregabalin, and the Combination of Duloxetine and Gabapentin Among Patients With Inadequate Response to Gabapentin for the Management of Diabetic Peripheral Neuropathic Pain	Completed	NCT00385671	Phase 4	duloxetine hydrochloride;pregabalin;gabapentin
44	A Multicenter Trial Evaluating the Safety and Efficacy of Cesamet™ for the Symptomatic Treatment of Chemotherapy-Induced Neuropathic Pain in Patients With Cancer	Completed	NCT00380965	Phase 4	Cesamet™ (nabilone)
45	Acute Effects of Sodium-glucose Cotransporter-2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes	Completed	NCT04193566	Phase 4	Forxiga
46	Gabapentin Kinetic Disposition and Renal Excretion: Role of Transporters for Organic Cations and the Effect of Glycemic Control in Patients With Neuropathic Pain.	Completed	NCT03047278	Phase 4	Gabapentin 300 mg;Cetirizine Hydrochloride 10 mg
47	Treatment With Alpha-lipoic Acid Over 16 Weeks in Type 2 Diabetic Patients With Symptomatic Polyneuropathy Who Responded to Initial 4-week High-dose Loading	Completed	NCT02439879	Phase 4	Alpha lipoic acid
48	An Open Label, Dose Finding Trial of Viagra for the Treatment of Neuropathic Pain (in Diabetes Mellitus)	Completed	NCT00194909	Phase 4	sildenafil (Viagra)
49	Efficacy of Pregabalin in Patients With Radicular Pain	Completed	NCT00908375	Phase 4	Pregabalin;Sugar Pill
50	A Comparison of Strategies for Switching Patients From Amitriptyline to Duloxetine for the Management of Diabetic Peripheral Neuropathic Pain	Completed	NCT00266643	Phase 4	duloxetine hydrochloride

Search NIH Clinical Center for Neuropathy

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Genetic Tests for Neuropathy

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Anatomical Context for Neuropathy

Organs/tissues related to Neuropathy:

FMA: Nerves

MalaCards : Dorsal Root Ganglion, Bone Marrow, Spinal Cord, Breast, Skin, Brain, Placenta

Sources

Publications for Neuropathy

Articles related to Neuropathy:

(show top 50) (show all 44910)

#	Title	Authors	PMID	Year
1	Charcot-Marie-Tooth-1A and sciatic nerve crush rat models: insights from proteomics. ⁶²	Msheik Z...Desmouliere A	36453423	2023
2	Hydrogen exerts neuroprotective effects by inhibiting oxidative stress in experimental diabetic peripheral neuropathy rats. ⁶²	Han XC...Fan DF	36204786	2023
3	Nonarteritic Anterior Ischemic Optic Neuropathy: Cystic Change in the Inner Nuclear Layer Caused by Edema and Retrograde Maculopathy. ⁶²	Chapelle AC...Plant GT	36439696	2023
4	Temporal Alterations of Sphingolipids in Optic Nerves After Indirect Traumatic Optic Neuropathy. ⁶²	Chauhan MZ...Bhattacharya SK	36275202	2023
5	The alteration of the expression level of neuropathy target esterase in human neuroblastoma SK-N-SH cells disrupts cellular phospholipids homeostasis. ⁶²	Hou WY...Wu YJ	36336212	2023
6	Establishment of a minimally invasive distal traumatic optic neuropathy model in mice to investigate cascade reactions of retinal glial cells. ⁶²	Shen B...Zhong Y	36468758	2023
7	Towards a mechanistic understanding of axon transport and endocytic changes underlying paclitaxel-induced peripheral neuropathy. ⁶²	Shin GJ	36279934	2023
8	Aging Muscles, Myositis, Pain, and Peripheral Neuropathies: PET Manifestations in the Elderly. ⁶²	Katal S...Gholamrezanezhad A	36442962	2023
9	Investigating the synergistic role of heavy metals in Arsenic-induced skin lesions in West Bengal, India. ⁶²	Banerjee S...Bhattacharjee P	36435151	2023
10	Migraine Headaches in Patients with Upper Extremity Compressive Neuropathy. ⁶²	Gfrerer L...Eberlin KR	36161789	2022
11	SGLT2-inhibitors reduce the cardiac autonomic neuropathy dysfunction and vaso-vagal syncope recurrence in patients with type 2 diabetes mellitus: the SCAN study. ⁶²	Sardu C...Marfella R	35732222	2022
12	Low T3 syndrome is associated with peripheral neuropathy in patients with type 2 diabetes mellitus. ⁶²	He W...Deng B	36089765	2022
13	Skin advanced glycation end products as a screening tool of neuropathy in type 2 diabetes mellitus. ⁶²	Papachristou S...Papanas N	36395605	2022
14	Mosaic vs. Single Image Analysis with Confocal Microscopy of the Corneal Nerve Plexus for Diagnosis of Early Diabetic Peripheral Neuropathy. ⁶²	Matuszewska-Iwanicka A...Hettlich HJ	36184730	2022
15	Small fiber neuropathy in hypermobile Ehlers Danlos syndrome/hypermobility spectrum disorder. ⁶²	Fernandez A...Suter MR	35781355	2022
16	Anxiety and depression in small fiber neuropathy. ⁶²	Damci A...Hoeijmakers JGJ	36168866	2022
17	Acute small fiber neuropathy after Oxford-AstraZeneca ChAdOx1-S vaccination: A report of three cases and review of the literature. ⁶²	Abbott MG...Themistocleous AC	35962630	2022
18	The diagnostic accuracy of the small fiber neuropathy symptoms inventory questionnaire (SFN-SIQ) for identifying pure small fiber neuropathy. ⁶²	Galosi E...Truini A	36175394	2022
19	Immunoglobulin Use for the Management of Painful Peripheral Neuropathy: A Systematic Review and Meta-Analysis. ⁶²	Zis P...Hadjigeorgiou G	35925489	2022
20	Alcoholic neuropathy associated with chronic alcohol intake. ⁶²	Tessitore ME...Cespedes IC	36065406	2022
21	Small-fibre neuropathy in patients with familial Amyotrophic Lateral Sclerosis type 8. ⁶²	Machado-Costa MC...Silva HCA	36457144	2022
22	The SPTLC1 p.S331 mutation bridges sensory neuropathy and motor neuron disease and has implications for treatment. ⁶²	Fiorillo C...Nolano M	35904184	2022
23	Neuropathic upper extremity pain: A double-crush scenario. ⁶²	Worthley E	36412937	2022
24	Vitamin D Status in a Bulgarian Population With Type 2 Diabetes and Diabetic Foot Ulcers. ⁶²	Todorova AS...Tankova TI	33094656	2022
25	Blinding Anemia: A Case of Bilateral Sequential Nonarteritic Ischemic Optic Neuropathy Secondary to Warm Autoimmune Hemolytic Anemia. ⁶²	O'Keeffe B...Aburn N	34803137	2022
26	Microvascular Burden and Incident Heart Failure Among Middle-Aged and Older Adults With Type 1 or Type 2 Diabetes. ⁶²	Li FR...Wu XB	35944243	2022
27	Alterations in Functional Connectivity of Thalamus and Primary Somatosensory Cortex in Painful and Painless Diabetic Peripheral Neuropathy. ⁶²	Croosu SS...Hansen TM	36469731	2022
28	Clinical scoring systems for the risk of cardiovascular autonomic neuropathy in type 1 and type 2 diabetes: A simple tool. ⁶²	Menduni M...Spallone V	36029134	2022
29	A case of herpes zoster ophthalmicus with optic neuritis of the total length of the optic nerve in the orbital space and ischemic optic neuropathy. ⁶²	Kudo T...Ueno S	36467120	2022
30	Peripapillary Microvascular and Structural Parameters in Atrophic Nonarteritic Anterior Ischemic Optic Neuropathy and Their Unaffected Fellow Eyes. ⁶²	Hondur G...Budakoglu O	35421878	2022
31	Construction and functional enrichment analysis of the competitive endogenous RNA regulatory network for nonarteritic anterior ischemic optic neuropathy based on high-throughput sequencing. ⁶²	Zhang M...Wang X	36355332	2022
32	Upregulation of retinal VEGF and connexin 43 in murine nonarteritic anterior ischemic optic neuropathy induced with 577 nm laser. ⁶²	Rangel B...Liao YJ	35691373	2022
33	Perioperative Ischemic Optic Neuropathy after Cardiac Surgery: Development and Validation of a Preoperative Risk Prediction Model. ⁶²	Shah SH...Roth S	36114093	2022
34	Bilateral Optic Nerve Enhancement in Posterior Ischemic Optic Neuropathy Secondary to Hypovolemic Shock. ⁶²	Tavakoli M...Vaphides MS	36394970	2022
35	Treatment outcomes of nanoliposomal irinotecan as second-line chemotherapy after gemcitabine and nab-paclitaxel in metastatic and recurrent pancreatic cancer. ⁶²	Mie T...Sasahira N	36111430	2022
36	Dysthyroid optic neuropathy: Demographics, risk factors, investigations, and management outcomes. ⁶²	Poonam NS...Mukherjee B	36453357	2022
37	Generation of GLA-knockout human embryonic stem cell lines to model peripheral neuropathy in Fabry disease. ⁶²	Kaneski CR...Schueler Hoffman UH	36092250	2022
38	The epidemiology and mutation types of Leber's hereditary optic neuropathy in Thailand. ⁶²	Sathianvichitr K...Chuenkongkaew W	35723074	2022
39	Quantitative assessment of macular and circumpapillary retinal vessel density across all stages of Leber hereditary optic neuropathy using swept source optical coherence tomography angiography. ⁶²	Castillo L...Casaroli-Marano R	35524395	2022
40	A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain. ⁶²	Pickering E...Vitetta L	36057884	2022
41	Clinical features of NOTCH2NLC-related neuronal intranuclear inclusion disease. ⁶²	Tian Y...Shen L	36150844	2022
42	Oral Nanocurcumin Alone or in Combination with Insulin Alleviates STZ-Induced Diabetic Neuropathy in Rats. ⁶²	Dwivedi S...Kumar MNVR	36106748	2022
43	Bortezomib-induced neurotoxicity in human neurons is the consequence of nicotinamide adenine dinucleotide depletion. ⁶²	Snavely AR...Woolf CJ	36398590	2022
44	Konzepte der Sturzrisikoabschätzung bei neurogeriatrischen Patienten. ⁶²	Mohwald K...Schniepp R	36459999	2022
45	Cisplatin-induced changes in calcitonin gene-related peptide or TNF-α release in rat dorsal root ganglia in vitro model of neurotoxicity are not reverted by rosiglitazone. ⁶²	Oliveira HR...Duarte DB	36228751	2022
46	Emerging roles of toll-like receptor 4 in chemotherapy-induced neurotoxicity. ⁶²	Oo TT...Chattipakorn SC	36152729	2022
47	Role of inflammation and oxidative stress in chemotherapy-induced neurotoxicity. ⁶²	Gupta P...Pahuja M	35859244	2022
48	A Randomized Controlled Phase 2 Study of Neoadjuvant Eribulin Versus Paclitaxel in Women with Operable Breast Cancer: The JONIE-3 Study. ⁶²	Narui K...Ishikawa T	36151017	2022
49	Glaucomatous optic neuropathy in relation to 24-h ambulatory blood pressure monitoring. ⁶²	Melgarejo JD...Zhang ZY	36445422	2022
50	Erratum to "Optic neuropathy in a COVID-19 patient" [J. Fr. Ophtalmol. 45 (2022) 1271-1273]. ⁶²	Borrego-Sanz L...Santos-Bueso E	36464528	2022

Sources

Genes for Neuropathy

Genes related to Neuropathy (0 elite genes):

(show top 50) (show all 92)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	DLX6-AS1	DLX6 Antisense RNA 1	RNA Gene	150	Experimental evidence: Regulation ³⁷	16705037
2	PMP22	Peripheral Myelin Protein 22	Protein Coding	56.75	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Gene name Summaries Pathways & Interactions (show sections)
3	MPZ	Myelin Protein Zero	Protein Coding	56.45	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Gene name Summaries Pathways & Interactions (show sections)
4	GDAP1	Ganglioside Induced Differentiation Associated Protein 1	Protein Coding	51.98	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Gene name Summaries Pathways & Interactions (show sections)
5	SLC12A6	Solute Carrier Family 12 Member 6	Protein Coding	50.57	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Gene name Summaries Pathways & Interactions (show sections)
6	GJB1	Gap Junction Protein Beta 1	Protein Coding	45.48	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Gene name Summaries (show sections)
7	MFN2	Mitofusin 2	Protein Coding	44.02	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries Pathways & Interactions (show sections)
8	MT-ND4	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 4	Protein Coding	43.66	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Gene name Summaries (show sections)
9	GAN	Gigaxonin	Protein Coding	43.26	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Gene name Summaries (show sections)
10	SPTLC1	Serine Palmitoyltransferase Long Chain Base Subunit 1	Protein Coding	41.86	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Gene name Summaries (show sections)
11	AIFM1	Apoptosis Inducing Factor Mitochondria Associated 1	Protein Coding	40.64	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Gene name Summaries (show sections)
12	WNK1	WNK Lysine Deficient Protein Kinase 1	Protein Coding	39.89	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Gene name Summaries (show sections)
13	DIAPH3	Diaphanous Related Formin 3	Protein Coding	38.91	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Gene name Summaries (show sections)
14	PNPLA6	Patatin Like Phospholipase Domain Containing 6	Protein Coding	34.07	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Gene name (show sections)
15	EGR2	Early Growth Response 2	Protein Coding	33.98	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Pathways & Interactions (show sections)
16	NGF	Nerve Growth Factor	Protein Coding	33.91	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
17	MT-ND6	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6	Protein Coding	33.44	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
18	MTMR2	Myotubularin Related Protein 2	Protein Coding	33.38	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries Pathways & Interactions (show sections)
19	POLG	DNA Polymerase Gamma, Catalytic Subunit	Protein Coding	33.37	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
20	PRX	Periaxin	Protein Coding	32.8	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
21	MT-ATP6	Mitochondrially Encoded ATP Synthase Membrane Subunit 6	Protein Coding	32.77	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
22	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	32.63	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries Pathways & Interactions (show sections)
23	SCN11A	Sodium Voltage-Gated Channel Alpha Subunit 11	Protein Coding	32.2	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
24	SH3TC2	SH3 Domain And Tetratricopeptide Repeats 2	Protein Coding	32.17	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Pathways & Interactions (show sections)
25	SBF2	SET Binding Factor 2	Protein Coding	32.1	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Gene name Pathways & Interactions (show sections)
26	SPTLC2	Serine Palmitoyltransferase Long Chain Base Subunit 2	Protein Coding	31.69	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
27	TDP1	Tyrosyl-DNA Phosphodiesterase 1	Protein Coding	31.69	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
28	RAB7A	RAB7A, Member RAS Oncogene Family	Protein Coding	31.5	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Gene name Pathways & Interactions (show sections)
29	KIF1A	Kinesin Family Member 1A	Protein Coding	31.47	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
30	DNM2	Dynamin 2	Protein Coding	31.44	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
31	HINT1	Histidine Triad Nucleotide Binding Protein 1	Protein Coding	31.38	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
32	SACS	Sacsin Molecular Chaperone	Protein Coding	31.33	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
33	RETREG1	Reticulophagy Regulator 1	Protein Coding	31.01	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
34	CCT5	Chaperonin Containing TCP1 Subunit 5	Protein Coding	30.94	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
35	SORD	Sorbitol Dehydrogenase	Protein Coding	30.91	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Functions (show sections)
36	MT-ND5	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 5	Protein Coding	30.88	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
37	MT-ND2	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 2	Protein Coding	30.67	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
38	KIF1B	Kinesin Family Member 1B	Protein Coding	30.55	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Gene name Pathways & Interactions (show sections)
39	ATL3	Atlastin GTPase 3	Protein Coding	30.47	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
40	SLC25A46	Solute Carrier Family 25 Member 46	Protein Coding	30.3	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
41	MT-ND4L	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 4L	Protein Coding	30.15	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
42	DNMT1	DNA Methyltransferase 1	Protein Coding	30	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
43	SYT2	Synaptotagmin 2	Protein Coding	29.89	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
44	CTDP1	CTD Phosphatase Subunit 1	Protein Coding	29.68	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
45	SNAP29	Synaptosome Associated Protein 29	Protein Coding	29.65	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Gene name (show sections)
46	MT-ND3	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 3	Protein Coding	29.63	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
47	AMACR	Alpha-Methylacyl-CoA Racemase	Protein Coding	28.99	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
48	GP1BA	Glycoprotein Ib Platelet Subunit Alpha	Protein Coding	28.26	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
49	SCN9A	Sodium Voltage-Gated Channel Alpha Subunit 9	Protein Coding	24.71	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
50	NEFL	Neurofilament Light Chain	Protein Coding	24.59	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)

Sources

Variations for Neuropathy

Copy number variations for Neuropathy from CNVD:

⁶

#	CNVD ID	Chromosome	Start	End	Type	Gene Symbol	CNVD Disease
1	107544	17	15900000	22100000	Microdeletion		Neuropathy
2	107574	17	16000000	22200000	Copy number		Neuropathy
3	216423	6	92100000	98700000	Microdeletion	EPHA7	Neuropathy

Sources

Expression for Neuropathy

Search GEO for disease gene expression data for Neuropathy.

Sources

Pathways for Neuropathy

Pathways related to Neuropathy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neural crest differentiation ⁷⁴	11.34	PMP22 MPZ GJB1
2	EGR2 and SOX10-mediated initiation of Schwann cell myelination ⁶⁶	10.7	PRX PMP22 MPZ EGR2
3	Intracellular trafficking proteins involved in CMT neuropathy ⁷⁴	10.53	PMP22 MTMR2 MPZ MFN2 GDAP1 EGR2

Sources

GO Terms for Neuropathy

Biological processes related to Neuropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial respiratory chain complex I assembly	GO:0032981	9.65	MT-ND6 MT-ND4 AIFM1
2	myelin assembly	GO:0032288	9.46	PMP22 MTMR2
3	peripheral nervous system development	GO:0007422	9.43	PMP22 NGF EGR2
4	myelination	GO:0042552	9.1	PMP22 MTMR2 MPZ EGR2