Aliases & Classifications for Neuropathy

MalaCards integrated aliases for Neuropathy:

Name: Neuropathy 12 15 39 17 71
Peripheral Neuropathy 12 71
Peripheral Neuropathies 15

Classifications:



External Ids:

Disease Ontology 12 DOID:870
NCIt 49 C4731
SNOMED-CT 67 42658009
ICD10 32 G62.9
UMLS 71 C0031117 C0442874

Summaries for Neuropathy

Disease Ontology : 12 A nervous system disease that is located in nerves or nerve cells.

MalaCards based summary : Neuropathy, also known as peripheral neuropathy, is related to neuropathy, hereditary, with liability to pressure palsies and neuropathy, hereditary sensory and autonomic, type v, and has symptoms including seizures, tremor and back pain. An important gene associated with Neuropathy is DLX6-AS1 (DLX6 Antisense RNA 1), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Aztreonam and Pravastatin have been mentioned in the context of this disorder. Affiliated tissues include nerves, breast and testes, and related phenotypes are behavior/neurological and cellular

Related Diseases for Neuropathy

Diseases in the Neuropathy family:

Autoimmune Neuropathy Hereditary Neuropathies

Diseases related to Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2730)
# Related Disease Score Top Affiliating Genes
1 neuropathy, hereditary, with liability to pressure palsies 35.2 SPTLC2 PMP22 MPZ MFN2 GJB1 GDAP1
2 neuropathy, hereditary sensory and autonomic, type v 35.1 WNK1 SPTLC1 NGF KIF1A
3 hypertrophic neuropathy of dejerine-sottas 35.0 SPTLC1 PMP22 MPZ MFN2 GJB1 GDAP1
4 neuropathy, hereditary sensory and autonomic, type iia 35.0 WNK1 SPTLC2 SPTLC1 SLC12A6 POLG NGF
5 hereditary sensory neuropathy 35.0 WNK1 SPTLC2 SPTLC1 NGF MPZ KIF1A
6 neuropathy, congenital hypomyelinating, 1, autosomal recessive 35.0 SPTLC2 SLC12A6 PMP22 MPZ MFN2 GJB1
7 hereditary sensory and autonomic neuropathy type 1 35.0 SPTLC2 SPTLC1 GDAP1
8 diabetic neuropathy 35.0 PMP22 NGF MPZ
9 neuropathy, hereditary sensory and autonomic, type i, with cough and gastroesophageal reflux 34.9 SPTLC2 SPTLC1
10 hereditary motor and sensory neuropathy, type iic 34.9 MPZ MFN2 GJB1 GDAP1
11 neuropathy, hereditary sensory and autonomic, type ia 34.9 WNK1 SPTLC2 SPTLC1
12 hereditary neuropathies 34.9 PMP22 MPZ MFN2 GJB1
13 autonomic neuropathy 34.8 WNK1 SPTLC2 SPTLC1 SCN11A NGF KIF1A
14 neuropathy, hereditary sensory and autonomic, type ic 34.8 SPTLC2 SPTLC1
15 sensory peripheral neuropathy 34.7 SPTLC1 SLC12A6 POLG PMP22 NGF MPZ
16 neuropathy, hereditary sensory, type ie 34.7 SPTLC2 SPTLC1
17 neuropathy, hereditary sensory and autonomic, type iib 34.7 WNK1 KIF1A
18 autoimmune peripheral neuropathy 34.6 MPZ GJB1
19 motor peripheral neuropathy 34.5 SLC12A6 PMP22 GJB1 GDAP1
20 peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease 34.5 MPZ GJB1
21 charcot-marie-tooth disease, x-linked dominant, 1 34.5 SPTLC1 PMP22 MPZ MFN2 GJB1 GDAP1
22 charcot-marie-tooth disease, demyelinating, type 1b 34.4 PMP22 MPZ MFN2 GJB1 GDAP1
23 charcot-marie-tooth disease, demyelinating, type 1a 34.4 PMP22 MPZ MFN2 GJB1 GDAP1
24 charcot-marie-tooth disease, axonal, type 2e 34.4 SPTLC1 SLC12A6 PMP22 NGF MPZ MFN2
25 charcot-marie-tooth disease, type 4d 34.4 MPZ GJB1 GDAP1
26 charcot-marie-tooth disease, axonal, type 2b 34.4 SPTLC1 MPZ MFN2 GJB1 GDAP1
27 axonal neuropathy 34.4 POLG PMP22 MFN2 KIF1A GDAP1 GAN
28 charcot-marie-tooth disease, axonal, type 2a1 34.3 MPZ MFN2 GDAP1
29 charcot-marie-tooth disease, demyelinating, type 1c 34.3 PMP22 MPZ GJB1 GDAP1
30 peripheral nervous system disease 34.3 SPTLC1 SCN11A POLG PNPLA6 PMP22 NGF
31 charcot-marie-tooth disease, demyelinating, type 1d 34.3 PMP22 MPZ GJB1 GDAP1
32 charcot-marie-tooth disease and deafness 34.3 SPTLC2 SPTLC1 PMP22 MPZ MFN2 GJB1
33 charcot-marie-tooth disease/hereditary motor and sensory neuropathy 34.3 SPTLC1 SLC12A6 PMP22 MPZ MFN2 GJB1
34 charcot-marie-tooth disease, type 4c 34.3 MPZ MFN2 GJB1 GDAP1
35 charcot-marie-tooth disease, axonal, type 2q 34.3 MPZ KIF1A GJB1
36 charcot-marie-tooth disease, type 4a 34.3 MPZ MFN2 GJB1 GDAP1
37 charcot-marie-tooth disease, dominant intermediate b 34.2 MPZ GJB1 GDAP1
38 charcot-marie-tooth disease, type 4b2 34.2 MPZ GJB1 GDAP1
39 charcot-marie-tooth disease, axonal, type 2b2 34.2 MPZ MFN2 GDAP1
40 optic nerve disease 34.2 POLG MT-ND4 MFN2 GDAP1
41 toxic optic neuropathy 34.2 MT-ND4 MFN2
42 asymmetric motor neuropathy 34.2 PMP22 MFN2
43 charcot-marie-tooth disease, dominant intermediate a 34.2 MPZ GJB1 GDAP1
44 charcot-marie-tooth disease, axonal, type 2d 34.2 MPZ MFN2 GJB1 GDAP1
45 charcot-marie-tooth disease, axonal, type 2f 34.2 SPTLC1 MPZ MFN2 GJB1 GDAP1
46 charcot-marie-tooth disease, axonal, type 2j 34.2 MPZ MFN2 GDAP1
47 charcot-marie-tooth disease, axonal, type 2t 34.2 SLC12A6 GDAP1 GAN
48 charcot-marie-tooth disease, axonal, type 2l 34.2 SPTLC1 MPZ MFN2 GDAP1
49 charcot-marie-tooth disease, axonal, type 2i 34.2 PMP22 MPZ MFN2 GJB1 GDAP1
50 brachial plexus neuropathy 34.1 PMP22 MPZ

Graphical network of the top 20 diseases related to Neuropathy:



Diseases related to Neuropathy

Symptoms & Phenotypes for Neuropathy

UMLS symptoms related to Neuropathy:


seizures, tremor, back pain, pain, headache, syncope, hemiparesis, chronic pain, sciatica, vertigo/dizziness, sleeplessness, neuralgia, neurologic symptoms, atypical facial pain

MGI Mouse Phenotypes related to Neuropathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 AIFM1 GAN GDAP1 GJB1 KIF1A MFN2
2 cellular MP:0005384 10.22 AIFM1 DIAPH3 GAN GDAP1 GJB1 GP1BA
3 growth/size/body region MP:0005378 10.21 AIFM1 DIAPH3 GAN GJB1 KIF1A MFN2
4 homeostasis/metabolism MP:0005376 10.17 AIFM1 DIAPH3 GDAP1 GJB1 GP1BA MFN2
5 integument MP:0010771 10 AIFM1 DIAPH3 GDAP1 KIF1A MPZ NGF
6 mortality/aging MP:0010768 10 AIFM1 DIAPH3 GAN GJB1 KIF1A MFN2
7 muscle MP:0005369 9.56 AIFM1 GAN MFN2 NGF PMP22 POLG
8 nervous system MP:0003631 9.5 AIFM1 GAN GDAP1 GJB1 KIF1A MFN2

Drugs & Therapeutics for Neuropathy

Drugs for Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 842)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
2
Pravastatin Approved Phase 4 81093-37-0 54687
3
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
4
Ofloxacin Approved Phase 4 82419-36-1 4583
5
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
6
Allopurinol Approved Phase 4 315-30-0 2094
7
Dorzolamide Approved Phase 4 120279-96-1 3154 5284549
8
Dinoprostone Approved Phase 4 363-24-6 5280360
9
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
10
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
11
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
12
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
13
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
14
Mexiletine Approved, Investigational Phase 4 31828-71-4 4178
15
Zidovudine Approved Phase 4 30516-87-1 35370
16
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
17
Rifampicin Approved Phase 4 13292-46-1 5458213 5381226
18
Lopinavir Approved Phase 4 192725-17-0 92727
19
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
20
Darunavir Approved Phase 4 635728-49-3, 206361-99-1 213039
21
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
22
Liraglutide Approved Phase 4 204656-20-2 44147092
23
Nevirapine Approved Phase 4 129618-40-2 4463
24
Timolol Approved Phase 4 26839-75-8 33624 5478
25
Levodopa Approved Phase 4 59-92-7 6047
26
Carbidopa Approved Phase 4 28860-95-9 34359
27
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
28
Glucagon Approved Phase 4 16941-32-5
29
Nortriptyline Approved Phase 4 72-69-5 4543
30
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
31
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
32
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
33
Methyltestosterone Approved Phase 4 58-18-4 6010
34
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 6013 10204
35
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
36
Testosterone enanthate Approved Phase 4 315-37-7 9416
37
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
38
Travoprost Approved Phase 4 157283-68-6 5282226
39
Glimepiride Approved Phase 4 93479-97-1 3476
40
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
41
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
42
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
43
Methimazole Approved Phase 4 60-56-0 1349907
44
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
45
Bezafibrate Approved, Investigational Phase 4 41859-67-0 39042
46
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
47
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
48
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
49
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
50
Methadone Approved Phase 4 76-99-3 4095

Interventional clinical trials:

(show top 50) (show all 2174)
# Name Status NCT ID Phase Drugs
1 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy. Multi-Center, Randomized Placebo Controlled Trial Unknown status NCT00123136 Phase 4
2 Treatment With Gamunex 10% Intravenous Immunoglobulin (IVIg) for Patients With Demyelination and Diabetes Mellitus: A Blinded, Placebo-Controlled Crossover Pilot Study Unknown status NCT02372149 Phase 4 10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
3 Evaluation of Viral Efficacy and Safety of a Reduced Dose of Stavudine (d4T): THE PHOENIX STUDY Unknown status NCT00235222 Phase 4 stavudine
4 An Open-Lable Multicenter Prospective Non-Randomized Trial to Assess the Efficacy and Safety of Morinidazole With Surgery in Patients With Suppurative or Gangrenous Appendicitis Unknown status NCT03380793 Phase 4 morinidazole
5 An Open-Lable Multicenter Prospective Non-Randomized Trial to Assess the Efficacy and Safety of Morinidazole With Levofloxacin and Sequential of Levofloxacin in Women With Pelvic Inflammatory Disease Unknown status NCT03391440 Phase 4 morinidazole
6 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
7 A Multicenter, Double-blind, Randomized, Placebo and Active-controlled Study of Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4 pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
8 Randomized Controlled Study to Evaluate the Efficacy of Pravastatin on Survival and Recurrence of Advanced Gastroesophageal Cancer Unknown status NCT01038154 Phase 4 Pravastatin
9 Inspiratory Muscle Training in Patients With Autonomic Neuropathic: a Randomized Trial Unknown status NCT00752440 Phase 4
10 Evaluation of the Impact of Subject and Staff Training on the Pregabalin vs. Placebo Difference in Subjects With Painful Diabetic Neuropathy (PDN) Unknown status NCT01770964 Phase 4 Pregabalin;placebo
11 The Effects of Omega-3 Fatty Acids on Chemotherapy-induced Neuropathy and Inflammation in Patients With Breast Cancer Unknown status NCT01049295 Phase 4
12 Botox on Vulvar Vestibulitis Unknown status NCT00119886 Phase 4 Botulinum toxin
13 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Unknown status NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
14 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
15 The Role of Qutenza (Topical Capsaicin 8%) in Treating Neuropathic Pain From Critical Ischaemia in Patients With End-stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
16 Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences. Unknown status NCT02033057 Phase 4
17 Effect of Allopurinol on Mono and Co-administration With Statins on Platelets Reactivity on Diabetic Patiets Treated With Aspirin and Insulin Unknown status NCT03195153 Phase 4 Atorvastatin 80mg;ALLOPURINOL 300 MG;Atorvastatin 80mg AND allopurinol 300 mg
18 A Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Intra-articular Catheter (IAC) Following Primary Total Knee Arthroplasty Unknown status NCT02497911 Phase 4 Ropivicaine;Bupivicaine
19 Effects of a Chronical Treatment With Benfotiamine in People With Type 2 Diabetes Mellitus on Pre- and Postprandial Endothelial Function, as Well as on the Function of the Autonomic Nervous System Unknown status NCT00446810 Phase 4 Benfotiamine;Placebo
20 Effects of Pregabalin on Mechanical Hyperalgesia - EPOM Unknown status NCT00310583 Phase 4 Pregabalin
21 A Double-Blinded Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Local Infiltration of Analgesia (LIA) Following Primary Total Knee Arthroplasty Unknown status NCT02603900 Phase 4 ropivacaine;bupivacaine
22 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
23 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4 Timolol & Dorzolamide
24 Absorption and Utilization of a Mixed Meal in Type 1 Diabetes: Creation of a Biological and In Silico Biobank for the Optimization of Artificial Pancreas Systems. A Pilot Study. Unknown status NCT01800734 Phase 4
25 A Prospective Single Blind Randomised Controlled Study to Compare the Outcomes of Patients With Diabetes and Clinically Non-infected Neuro-ischaemic and Neuropathic Foot Ulcers Treated With and Without Oral Antibiotics. Unknown status NCT01418456 Phase 4 antibiotics
26 Multicentre Randomised Controled Trial Comparing the Effect of a New Self-gripping Lightweight Polyester Mesh and a Normal Sutured Lightweight Polyester Mesh on the Incidence of Chronic Inguinodynia in Lichtenstein Hernioplasty. Unknown status NCT01830452 Phase 4
27 An Open-label, Randomized, Multi-center Clinical Trial to Evaluate the Safety and Efficacy in Peripheral Neuropathies Patients Treated With Mecobalamin Injection Completed NCT01192113 Phase 4 Mecobalamin IV Injection;Mecobalamin IM injection;Mecobalamin IV or IM injection
28 Efficacy of Administration of Angiotensin Converting Enzyme Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
29 A 14-Week, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study To Evaluate The Safety And Efficacy Of Pregabalin (150mg-600mg/Day) Using A Flexible Optimal Dose Schedule In Patients With Painful Diabetic Peripheral Neuropathy (DPN). Completed NCT00156078 Phase 4 pregabalin
30 A Prospective, Open Label, Multi-Center, Study Of Pregabalin In The Treatment Of Neuropathic Pain Associated With Diabetic Peripheral Neuropathy, Postherpetic Neuralgia, HIV-Related Peripheral Neuropathic Pain And Chemotherapy Induced Peripheral Neuropathic Pain Completed NCT00407511 Phase 4 Pregabalin
31 A Multicenter Trial Evaluating the Efficacy of Cesamet™ for the Symptomatic Treatment of Pain in Patients With Diabetic Peripheral Neuropathy Completed NCT00380913 Phase 4 Cesamet™ (nabilone)
32 An Open Label Extension Safety Trial of Pregabalin (CI-1008) in Subjects With Diabetic Peripheral Neuropathy Completed NCT00159731 Phase 4 Pregabalin
33 A 13 Week, Double-Blind, Placebo-Controlled Phase 4 Trial of Pregabalin (CI-1008, 600 mg/Day) for Relief of Pain in Subjects With Painful Diabetic Peripheral Neuropathy Completed NCT00159679 Phase 4 Pregabalin
34 A 24 Week, Double-blind, Placebo-controlled, Multisite Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN) Completed NCT00726713 Phase 4
35 Efficacy and Safety of Pregabalin in an Open-label, Non-comparative, Flexible-dose Trial With Diabetic Peripheral Neuropathy or Postherpetic Neuralgia Completed NCT00629681 Phase 4 Pregabalin
36 A Randomized, Single-dose, Parallel-group Study to Evaluate the Pharmacokinetic Profiles of Two Formulation of Pregabalin in Healthy Volunteers Under Fasting Conditions Completed NCT03712475 Phase 4 Pregabalin
37 A Randomized, Double Blind, Placebo Controlled Prospective Study to Evaluate the Effectiveness of Monochromatic Infrared Photo Energy to Improve Diabetic Sensory Neuropathy Completed NCT00120341 Phase 4
38 A Phase IV Clinical Trial. Effect of Pulsing Electromagnetic Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study Completed NCT00614341 Phase 4
39 A Multicenter Trial Evaluating the Safety and Efficacy of Cesamet™ for the Symptomatic Treatment of Chemotherapy-Induced Neuropathic Pain in Patients With Cancer Completed NCT00380965 Phase 4 Cesamet™ (nabilone)
40 Neuroprotective Effect of Vitamin B12 and Vitamin B6 Against Vincristine Induced Peripheral Neuropathy: A Randomized, Double Blind, Placebo Controlled, Multi Center Trial Completed NCT02923388 Phase 4 Injection Mecobalamin,;Tablet Pyridoxine hydrochloride;Intravenous normal saline 1 ml;Placebo pill
41 A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy Who Need Opioid Combination Treatment With Existing Pregabalin Treatment Completed NCT01675531 Phase 4 Targin
42 Multicenter, Randomized, Open-label, Parallel Group, Phase IV Study to Compare the Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in the Management of Diabetic Peripheral Neuropathic Pain Completed NCT01364298 Phase 4 Gabapentin/B-complex;Pregabalin
43 L-Arginine and Endothelial Dysfunction in Type 2 Diabetic Patients Completed NCT00902616 Phase 4
44 Evaluation of a Structured Algorithm for Intrathecal Bolus Doses of Ziconotide (Prialt®)- The Swedish Ziconotide Bolus Study Completed NCT01373983 Phase 4 Ziconotide
45 Safety and Efficacy of Nab-paclitaxel (Abraxane) in Combination With Carboplatin as First Line Treatment in Elderly Subjects With Advance Non-Small Cell Lung Cancer (NSCLC): A Phase IV, Randomized, Open-Label, Multicenter Study (Abound.70+) Completed NCT02151149 Phase 4 nab-paclitaxel;Carboplatin
46 Long Term, Double Blind, Randomized, Placebo Controlled Multi-center Study of FRE.M.S.- Frequency Modulated Neural Stimulation Lorenz Therapy™ in Symptomatic Diabetic Neuropathy Completed NCT01628627 Phase 4
47 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
48 An Open-Label Trial of Duloxetine for the Treatment of Irritable Bowel Syndrome Without Comorbid Major Depressive Disorder Completed NCT00401258 Phase 4 duloxetine
49 Pilot Phase IV, Multicenter, Randomized, Open-label and Controlled Study to Assess the Evolution of Peripheral Body Fat Distribution After Switching From Zidovudine Containing Backbone to Truvada in HIV-1-infected Patients on HAART (RECOMB Study). Completed NCT00324649 Phase 4 Truvada;Zidovudine/lamivudine
50 Randomized Double-blind Study Comparing the Efficacy of Duloxetine With Placebo in Patients With Chronic Low Back Pain With a Radicular Component Completed NCT01166048 Phase 4 Duloxetine;Duloxetine

Search NIH Clinical Center for Neuropathy

Genetic Tests for Neuropathy

Anatomical Context for Neuropathy

The Foundational Model of Anatomy Ontology organs/tissues related to Neuropathy:

19
Nerves

MalaCards organs/tissues related to Neuropathy:

40
Breast, Testes, Skin, Lung, Heart, Brain, Bone

Publications for Neuropathy

Articles related to Neuropathy:

(show top 50) (show all 39646)
# Title Authors PMID Year
1
Sphingosine-1-phosphate receptor 2 modulates pain sensitivity by suppressing the ROS-RUNX3 pathway in a rat model of neuropathy. 61
31603252 2020
2
Visual field and orbital computed tomography correlation in dysthyroid optic neuropathy due to thyroid eye disease. 61
31057005 2020
3
Lipidomics dataset of sonication-induced traumatic optic neuropathy in mice. 61
32021890 2020
4
A retrospective analysis of the prevalence and clinical outcomes of vitamin D deficiency in myeloma patients in tropical Australia. 61
31227990 2020
5
Anterior ischemic optic neuropathy in a patient with papilledema from idiopathic intracranial hypertension. 61
31956730 2020
6
Clinical and Optic Disc Characteristics of Patients Showing Visual Recovery in Leber Hereditary Optic Neuropathy. 61
31609832 2020
7
Multilocus Mitochondrial Mutations Do Not Directly Affect the Efficacy of Gene Therapy for Leber Hereditary Optic Neuropathy. 61
31246675 2020
8
A recurrent missense variant in HARS2 results in variable sensorineural hearing loss in three unrelated families. 61
31827252 2020
9
Connecting endoplasmic reticulum and oxidative stress to retinal degeneration, TBI, and traumatic optic neuropathy. 61
31642095 2020
10
Cycle Training improves vascular function and neuropathic symptoms in patients with type 2 diabetes and peripheral neuropathy: A randomized controlled trial. 61
31899340 2020
11
Pathogenesis of platinum-induced peripheral neurotoxicity: Insights from preclinical studies. 61
31865195 2020
12
Multiple-Image Deep Learning Analysis for Neuropathy Detection in Corneal Nerve Images. 61
31658167 2020
13
Cav-1 participates in the development of diabetic neuropathy pain through the TLR4 signaling pathway. 61
31318049 2020
14
Scrambler therapy for chemotherapy neuropathy: a randomized phase II pilot trial. 61
31209630 2020
15
Cluster and Factor Analysis of Elements in Serum and Urine of Diabetic Patients with Peripheral Neuropathy and Healthy People. 61
31140035 2020
16
Study of the possible synergistic protective effects of Melatonin and Pregabalin in Vincristine induced peripheral neuropathy Wistar Albino rats. 61
31816326 2020
17
Isolated light chain deposition disease neuropathy in a patient with multiple myeloma. 61
31566029 2020
18
Methods for in vivo studies in rodents of chemotherapy induced peripheral neuropathy. 61
31837318 2020
19
Toward a new definition of glaucomatous optic neuropathy for clinical research. 61
31922980 2020
20
Cobalt toxic optic neuropathy and retinopathy: Case report and review of the literature. 61
32025592 2020
21
The rare Alus element-mediated chimerism of multiple de novo complex rearrangement sequences in GAN result in giant axonal neuropathy. 61
31877298 2020
22
Ginger extract and its compound, 6-shogaol, attenuates painful diabetic neuropathy in mice via reducing TRPV1 and NMDAR2B expressions in the spinal cord. 61
31743763 2020
23
EV-101: A Phase I Study of Single-Agent Enfortumab Vedotin in Patients With Nectin-4-Positive Solid Tumors, Including Metastatic Urothelial Carcinoma. 61
32031899 2020
24
Brentuximab Vedotin in the Treatment of Peripheral T Cell Lymphoma and Cutaneous T Cell Lymphoma. 61
32016790 2020
25
Autonomic Peripheral Neuropathy. 61
31996622 2020
26
Demyelinating Neuropathy Due to Intravascular Large B-cell Lymphoma. 61
31588080 2020
27
A fatal case of bortezomib-induced lung toxicity in a young adult heart transplant recipient. 61
31815325 2020
28
Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy. 61
32011655 2020
29
Peripheral nerve conductions in relapsing remitting multiple sclerosis (RRMS) patients. 61
32029369 2020
30
Prediabetes, diabetes, metabolic syndrome and small fiber neuropathy. 61
32012301 2020
31
Prevalence of denervation in the intrinsic foot muscles in patients with distal predominantly small fiber neuropathy. 61
32034782 2020
32
The small fiber neuropathy NaV1.7 I228M mutation: impaired neurite integrity via bioenergetic and mitotoxic mechanisms, and protection by dexpramipexole. 61
31851560 2020
33
Correction to: The Association Between Phosphorylated Neurofilament Heavy Chain (pNF-H) and Small Fiber Neuropathy (SFN) in Patients with Impaired Glucose Tolerance. 61
31865611 2020
34
The Contemporary Prevalence of Diabetic Neuropathy in Type 1 Diabetes: Findings From the T1D Exchange. 61
32029635 2020
35
Prognostic factor of poor outcome in anti-MAG neuropathy: clinical and electrophysiological analysis of a French Cohort. 61
31705291 2020
36
Bortezomib with standard chemotherapy for children with acute myeloid leukemia does not improve treatment outcomes: a report from the Children's Oncology Group. 61
32029509 2020
37
Bony orbital changes in allergic fungal sinusitis are reversible after treatment. 61
31169421 2020
38
Gait changes in persons with diabetes: Early risk marker for diabetic foot ulcer. 61
30712991 2020
39
Ankle fusion following failed initial treatment of complex ankle fractures in neuropathic diabetics. 61
30772132 2020
40
Treatment-Induced Neuropathy of Diabetes (TIND) in Pediatrics: A Case Report and Review of the Literature. 61
31613321 2020
41
Ulnar neuropathy at the elbow: Reappraisal of the wrist-upper arm latency difference between ulnar and median nerves. 61
31865138 2020
42
Cryotherapy for the prevention of weekly paclitaxel-induced peripheral adverse events in breast cancer patients. 61
32036471 2020
43
Re: Parisi et al.: Functional changes of retinal ganglion cells and visual pathways in patients with chronic Leber's hereditary optic neuropathy during one year of follow-up (Ophthalmology. 2019;126:1033-1044). 61
31973837 2020
44
A simple method of quantifying chemotherapy-induced peripheral neuropathy using PainVision PS-2100®. 61
31774247 2020
45
Small fiber neuropathy in Sjögren's syndrome: comparison with other small fiber neuropathies. 61
32012291 2020
46
Electrophysiological Characterization of C9ORF72-Associated Amyotrophic Lateral Sclerosis: A Retrospective Study. 61
32018264 2020
47
Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases. 61
31552888 2020
48
Native versus deglycosylated IgM in anti-MAG neuropathy: Correlation with clinical status - Study of 10 cases. 61
31756640 2020
49
Association of variability in antibody binding affinity with a clinical course of anti-MAG neuropathy. 61
31841738 2020
50
Outcomes of audiometric testing in children with auditory neuropathy spectrum disorder. 61
31704576 2020

Variations for Neuropathy

Copy number variations for Neuropathy from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 107544 17 15900000 22100000 Microdeletion Neuropathy
2 107574 17 16000000 22200000 Copy number Neuropathy
3 216423 6 92100000 98700000 Microdeletion EPHA7 Neuropathy

Expression for Neuropathy

Search GEO for disease gene expression data for Neuropathy.

Pathways for Neuropathy

Pathways related to Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 PMP22 MPZ GJB1

GO Terms for Neuropathy

Cellular components related to Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.03 WNK1 SPTLC2 SPTLC1 SLC12A6 SCN11A POLG
2 integral component of membrane GO:0016021 9.77 SPTLC2 SPTLC1 SLC12A6 SCN11A POLG PNPLA6
3 serine C-palmitoyltransferase complex GO:0017059 8.62 SPTLC2 SPTLC1

Biological processes related to Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial fusion GO:0008053 9.32 MFN2 GDAP1
2 sphingosine biosynthetic process GO:0046512 9.26 SPTLC2 SPTLC1
3 sphingomyelin biosynthetic process GO:0006686 9.16 SPTLC2 SPTLC1
4 positive regulation of lipophagy GO:1904504 8.96 SPTLC2 SPTLC1
5 sphinganine biosynthetic process GO:0046511 8.62 SPTLC2 SPTLC1

Molecular functions related to Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine C-palmitoyltransferase activity GO:0004758 8.62 SPTLC2 SPTLC1

Sources for Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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