Neuropathy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: NRP001 MIFTS: 62	Neuropathy Categories: Immune diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Neuropathy

MalaCards integrated aliases for Neuropathy:

Name: Neuropathy ¹² ¹⁵ ⁴⁰ ⁷³

Peripheral Neuropathy ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the nervous system

Polyneuropathies and other disorders of the peripheral nervous system

Other polyneuropathies

Polyneuropathy, unspecified

External Ids:

Disease Ontology ¹² DOID:870

ICD10 ³³ G62.9

NCIt ⁵⁰ C4731

SNOMED-CT ⁶⁸ 42658009

UMLS ⁷³ C0442874 C0031117

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Summaries for Neuropathy

Disease Ontology : ¹² A nervous system disease that is located in nerves or nerve cells.

MalaCards based summary : Neuropathy, also known as peripheral neuropathy, is related to neuropathy, hereditary, with liability to pressure palsies and neuropathy, hereditary sensory, type ie, and has symptoms including seizures, tremor and back pain. An important gene associated with Neuropathy is DLX6-AS1 (DLX6 Antisense RNA 1), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Pregabalin and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and heart, and related phenotypes are behavior/neurological and cellular

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Related Diseases for Neuropathy

Diseases in the Neuropathy family:

Autoimmune Neuropathy	Hereditary Type 1 Neuropathy
Hereditary Type 2 Neuropathy	Neuropathy - Hereditary

Diseases related to Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1609)

#	Related Disease	Score	Top Affiliating Genes
1	neuropathy, hereditary, with liability to pressure palsies	34.1	GDAP1 GJB1 MFN2 MPZ PMP22
2	neuropathy, hereditary sensory, type ie	34.1	SPTLC1 SPTLC2
3	neuropathy, congenital hypomyelinating or amyelinating, autosomal recessive	34.1	GDAP1 GJB1 MFN2 MPZ PMP22
4	hypertrophic neuropathy of dejerine-sottas	34.0	GDAP1 GJB1 MPZ PMP22
5	neuropathy, hereditary sensory and autonomic, type ic	33.9	SPTLC1 SPTLC2
6	hereditary sensory and autonomic neuropathy type 1	33.8	SPTLC1 SPTLC2
7	hereditary sensory neuropathy	33.8	KIF1A NGF SPTLC1 SPTLC2 WNK1
8	autonomic neuropathy	33.8	KIF1A NGF SPTLC1 SPTLC2 WNK1
9	neuropathy - hereditary	33.8	MPZ PMP22 SCN11A SPTLC1
10	hereditary motor and sensory neuropathy, type iic	33.8	GDAP1 GJB1 MFN2 MPZ
11	sensory peripheral neuropathy	33.7	GDAP1 GJB1 MFN2 MPZ NGF PMP22
12	motor peripheral neuropathy	33.6	GJB1 MFN2 MPZ PMP22
13	charcot-marie-tooth disease, demyelinating, type 1b	33.5	GJB1 MPZ PMP22
14	charcot-marie-tooth hereditary neuropathy	33.5	MPZ PMP22
15	charcot-marie-tooth disease, axonal, type 2e	33.5	GAN GDAP1 GJB1 MFN2 MPZ PMP22
16	charcot-marie-tooth disease, axonal, type 2b	33.4	GJB1 MPZ PMP22 SPTLC1
17	charcot-marie-tooth disease, demyelinating, type 1c	33.4	GJB1 MPZ PMP22
18	congenital hypomyelination neuropathy	33.4	MPZ PMP22
19	charcot-marie-tooth disease, x-linked dominant, 1	33.4	GJB1 MPZ PMP22
20	axonal neuropathy	33.3	GAN GDAP1 MFN2 PMP22 POLG
21	charcot-marie-tooth disease and deafness	33.3	GDAP1 GJB1 MFN2 MPZ PMP22
22	sensory neuropathy type 1	33.2	GJB1 SPTLC1
23	charcot-marie-tooth disease, type 4d	33.2	GDAP1 GJB1 MFN2
24	charcot-marie-tooth disease, demyelinating, type 1d	33.2	GJB1 MPZ PMP22
25	charcot-marie-tooth disease, axonal, type 2f	33.2	GJB1 MPZ
26	charcot-marie-tooth disease, demyelinating, type 1a	33.1	GDAP1 GJB1 MFN2 MPZ PMP22
27	charcot-marie-tooth disease, demyelinating, type 1f	33.1	GJB1 MPZ PMP22
28	charcot-marie-tooth disease, axonal, type 2d	33.1	GJB1 MPZ PMP22
29	charcot-marie-tooth disease, axonal, type 2k	33.1	GDAP1 KIF1A MFN2
30	peripheral nervous system disease	33.0	GAN GDAP1 GJB1 MFN2 MPZ MT-ND4
31	charcot-marie-tooth disease	32.9	AIFM1 GAN GDAP1 GJB1 MFN2 MPZ
32	roussy-levy hereditary areflexic dystasia	32.5	MPZ PMP22
33	charcot-marie-tooth disease type 2a2	32.2	GAN MFN2
34	polyneuropathy	32.1	GDAP1 MPZ PMP22 PNPLA6 POLG
35	hereditary spastic paraplegia	32.1	CCT5 GAN KIF1A PNPLA6
36	foot drop	32.0	MPZ PMP22
37	spinocerebellar degeneration	31.7	PNPLA6 POLG
38	cranial nerve disease	31.3	MFN2 MT-ND4 POLG
39	myoclonic epilepsy associated with ragged-red fibers	31.3	GDAP1 MT-ND4 POLG
40	tooth disease	31.0	GDAP1 GJB1 MFN2 MPZ PMP22
41	amyotrophic neuralgia	30.3	GJB1 PMP22
42	chronic inflammatory demyelinating polyradiculoneuropathy	30.0	MPZ PMP22
43	neurogenic arthropathy	29.7	NGF SPTLC1
44	neuropathy, hereditary sensory and autonomic, type iia	12.5
45	neuropathy, hereditary sensory and autonomic, type v	12.4
46	nonarteritic anterior ischemic optic neuropathy	12.4
47	neuromyotonia and axonal neuropathy, autosomal recessive	12.4
48	neuropathy, hereditary sensory and autonomic, type vii	12.4
49	neuropathy, hereditary sensory and autonomic, type vi	12.4
50	diabetic neuropathy	12.4

Graphical network of the top 20 diseases related to Neuropathy:

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Symptoms & Phenotypes for Neuropathy

UMLS symptoms related to Neuropathy:

seizures, tremor, back pain, pain, headache, syncope, hemiparesis, chronic pain, sciatica, vertigo/dizziness, sleeplessness, neuralgia, neurologic symptoms, atypical facial pain

MGI Mouse Phenotypes related to Neuropathy:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.21	AIFM1 GAN GDAP1 GJB1 KIF1A MFN2
2	cellular	MP:0005384	10.18	AIFM1 DIAPH3 GAN GDAP1 GJB1 GP1BA
3	homeostasis/metabolism	MP:0005376	10.17	AIFM1 DIAPH3 GDAP1 GJB1 GP1BA MFN2
4	growth/size/body region	MP:0005378	10.15	AIFM1 DIAPH3 GAN GJB1 KIF1A MFN2
5	mortality/aging	MP:0010768	10	AIFM1 DIAPH3 GAN GJB1 KIF1A MFN2
6	integument	MP:0010771	9.86	AIFM1 DIAPH3 KIF1A NGF PNPLA6 POLG
7	muscle	MP:0005369	9.5	AIFM1 GAN MFN2 NGF PMP22 POLG
8	nervous system	MP:0003631	9.47	AIFM1 GAN GDAP1 GJB1 KIF1A MFN2

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Drugs & Therapeutics for Neuropathy

Drugs for Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 975)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Pregabalin

Approved, Illicit, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

148553-50-8

5486971

Gabapentin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

60142-96-3

3446

gamma-Aminobutyric acid

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

56-12-2

119

Stavudine

Approved, Investigational

Phase 4,Phase 3

3056-17-5

18283

AT-101

Approved, Investigational

Phase 4,Phase 3

90141-22-3, 652-67-5

12597

Nitric Oxide

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

10102-43-9

145068

Isosorbide Dinitrate

Approved, Investigational

Phase 4,Phase 3

87-33-2

6883

Dorzolamide

Approved

Phase 4,Not Applicable

120279-96-1

5284549 3154

Timolol

Approved

Phase 4,Phase 3,Phase 1,Not Applicable

26839-75-8

33624 5478

Fexofenadine

Approved, Investigational

Phase 4

83799-24-0

3348

Histamine

Approved, Investigational

Phase 4,Phase 2

51-45-6, 75614-87-8

774

Colistin

Approved

Phase 4

1264-72-8, 1066-17-7

5311054

Morphine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

57-27-2

5288826

Acetaminophen

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

103-90-2

1983

Ibuprofen

Approved

Phase 4,Phase 2,Phase 3,Not Applicable

15687-27-1

3672

Saxagliptin

Approved

Phase 4,Not Applicable

361442-04-8

11243969

Levofloxacin

Approved, Investigational

Phase 4,Phase 2,Phase 3,Not Applicable

100986-85-4

149096

Aztreonam

Approved

Phase 4

78110-38-0

5362041 5742832

Clindamycin

Approved, Vet_approved

Phase 4,Not Applicable

18323-44-9

29029

Amoxicillin

Approved, Vet_approved

Phase 4,Phase 3,Phase 1,Not Applicable

26787-78-0

33613

Linezolid

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2

165800-03-3

441401

Ofloxacin

Approved

Phase 4,Phase 2,Phase 3,Not Applicable

82419-36-1

4583

Piperacillin

Approved

Phase 4,Phase 3

66258-76-2

43672

Metronidazole

Approved

Phase 4,Phase 3,Phase 2

443-48-1

4173

Tazobactam

Approved

Phase 4,Phase 3

89786-04-9

123630

Hydroxocobalamin

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

13422-51-0

11953898 44475014

Methylcobalamin

Approved, Experimental, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

13422-55-4

leucovorin

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

58-05-9

6006 143

Nabilone

Approved, Investigational

Phase 4,Phase 3

51022-71-0

5284592

Lidocaine

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

137-58-6

3676

Nortriptyline

Approved

Phase 4,Phase 2,Not Applicable

72-69-5

4543

Carbamazepine

Approved, Investigational

Phase 4,Not Applicable

298-46-4

2554

tannic acid

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Benzocaine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

94-09-7, 1994-09-7

2337

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

83-43-2

6741

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

50-24-8

5755

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

302-25-0

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

2921-57-5

Amitriptyline

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

50-48-6

2160

Paclitaxel

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

33069-62-4

36314

Carboplatin

Approved

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

41575-94-4

10339178 38904 498142

Bevacizumab

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1

216974-75-3

Travoprost

Approved

Phase 4,Phase 3

157283-68-6

5282226

Latanoprost

Approved, Investigational

Phase 4

130209-82-4

5311221 5282380

Diclofenac

Approved, Vet_approved

Phase 4,Phase 3,Not Applicable

15307-86-5

3033

rituximab

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

174722-31-7

10201696

Bortezomib

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

179324-69-7

387447 93860

Angiotensin II

Approved, Investigational

Phase 4,Phase 2,Not Applicable

11128-99-7, 68521-88-0, 4474-91-3

172198 65143

Fluorouracil

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

51-21-8

3385

Oxaliplatin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

61825-94-3

43805 6857599 5310940 9887054

Interventional clinical trials:

(show top 50) (show all 2636)

#	Name	Status	NCT ID	Phase	Drugs
1	Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy	Unknown status	NCT00123136	Phase 4
2	Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy	Unknown status	NCT01770964	Phase 4	Pregabalin;placebo
3	Omega-3 Fatty Acids and Chemotherapy-induced Neuropathy and Inflammation in Breast Cancer	Unknown status	NCT01049295	Phase 4
4	Inspiratory Muscle Training in Patients With Autonomic Neuropathic	Unknown status	NCT00752440	Phase 4
5	IVIg for Demyelination in Diabetes Mellitus	Unknown status	NCT02372149	Phase 4	10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
6	The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair	Unknown status	NCT02419443	Phase 4	Gabapentin;Placebo
7	Evaluation of Viral Efficacy and Safety of a Reduced Dose of Stavudine (d4T): THE PHOENIX STUDY	Unknown status	NCT00235222	Phase 4	stavudine
8	Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus	Unknown status	NCT00446810	Phase 4	Benfotiamine;Placebo
9	Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus	Unknown status	NCT02011620	Phase 4
10	Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences.	Unknown status	NCT02033057	Phase 4
11	Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients	Unknown status	NCT02053298	Phase 4	Timolol & Dorzolamide
12	Pregabalin for the Treatment of Uremic Pruritus	Unknown status	NCT01852318	Phase 4	pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
13	Colistin Pharmacokinetics in Continuous Renal Replacement Therapy	Unknown status	NCT02081560	Phase 4	Colistin
14	Duration of Antibiotic Therapy in Community - Acquired Pneumonia	Unknown status	NCT01492387	Phase 4
15	Ultrasound-guided Caudal or Interlaminar Corticosteroid Epidural Injection for Sciatica	Unknown status	NCT02897336	Phase 4
16	IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia	Unknown status	NCT02504996	Phase 4	Paracetamol;morphine;Placebo
17	Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department	Unknown status	NCT02777320	Phase 4	paracetamol;Ibuprofen
18	Maggot Debridement Therapy Versus Conventional Dressing Therapy to Treat Diabetic Foot Ulcers	Unknown status	NCT02816749	Phase 4
19	Dipeptidyl Peptidase 4 Inhibition Facilitate Healing of Diabetic Ulcers	Unknown status	NCT02742233	Phase 4	saxagliptin;placebo
20	A Comparative Efficacy Study of DermaPure™ to Treat Diabetic Foot Ulcers	Unknown status	NCT02081352	Phase 4
21	Efficacy and Safety of Garamycin® Sponge (Gentamicin-Collagen Sponge) in Diabetic Patients With a Moderate or Severe Foot Ulcer Infection	Unknown status	NCT01951768	Phase 4	Garamycin Sponge (Gentamicin-Collagen sponge);Systemic Antibiotic
22	Clinical Evaluation of the SNaP Wound Care System	Unknown status	NCT01113658	Phase 4
23	Safety and Efficacy of Mecobalamin Injection in Peripheral Neuropathies Patients (Study JGAZSY091109)	Completed	NCT01192113	Phase 4	Mecobalamin IV Injection;Mecobalamin IM injection;Mecobalamin IV or IM injection
24	The Effect of α-lipoic Acid Treatment in Patient With Cardiac Autonomic Neuropathy	Completed	NCT02056366	Phase 4	α-lipoic acid
25	Frequency Modulated Neural Stimulation (FREMS) in Symptomatic Diabetic Neuropathy	Completed	NCT01628627	Phase 4
26	A Randomized Double-Blind Study Testing the Effects of Pregabalin on Diabetic Neuropathy	Completed	NCT00573261	Phase 4	Pregabalin;Placebo
27	Effect of Pulsing Electrical Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study	Completed	NCT00614341	Phase 4
28	Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN)	Completed	NCT00726713	Phase 4
29	Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus	Completed	NCT03031834	Phase 4	Quinapril
30	Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)	Completed	NCT03046693	Phase 4	Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
31	A Study on the Efficacy and Safety of Gabapentin in the Treatment of Patients With Painful Diabetic Neuropathy	Completed	NCT00644748	Phase 4	gabapentin
32	A Study to Compare Safety and Efficacy of Tramadol Hydrochloride/Acetaminophen With Gabapentin in Participants With Diabetic Neuropathy	Completed	NCT00634543	Phase 4	Tramadol hydrochloride/ Acetaminophen;Gabapentin
33	A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)	Completed	NCT01975324	Phase 4	dalfampridine;Placebo
34	Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Diabetic Peripheral Neuropathy	Completed	NCT00380913	Phase 4	Cesamet™ (nabilone)
35	Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy	Completed	NCT00159679	Phase 4	Pregabalin
36	A Study To Evaluate Pregabalin In Patients With Painful Diabetic Peripheral Neuropathy (DPN)	Completed	NCT00156078	Phase 4	pregabalin
37	Anodyne Therapy in Diabetic Sensory Neuropathy	Completed	NCT00120341	Phase 4
38	A Study of the Efficacy and Safety of Pregabalin for the Treatment of Diabetic Peripheral Neuropathy or Postherpetic Neuralgia	Completed	NCT00629681	Phase 4	Pregabalin
39	Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy	Completed	NCT00432393	Phase 4	levodopa-carbidopa
40	Evaluation of Rocker sOles in Diabetis	Completed	NCT02891928	Phase 4
41	Safety of Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy	Completed	NCT00159731	Phase 4	Pregabalin
42	A Study of the Effectiveness And Safety Of Lidoderm® As Add-On Treatment in Patients With Postherpetic Neuralgia, Diabetic Neuropathy, or Low Back Pain	Completed	NCT00904020	Phase 4	Lidoderm
43	Alpha Lipoic Acid for Treatment of Diabetic Neuropathy	Completed	NCT02439879	Phase 4	Alpha lipoic acid
44	A Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy (CIPN)	Completed	NCT01675531	Phase 4	Targin
45	Lidoderm® (Lidocaine Patch 5%) in Diabetic and Idiopathic Neuropathy	Completed	NCT00903851	Phase 4	Lidoderm
46	Clinical Study for Assessment of the Efficacy of Gabapentin (Carbatin and Neurontin) in Patients With Neuropathy Pain	Completed	NCT02074267	Phase 4	Carbatin;Neurontin
47	Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations	Completed	NCT02260388	Phase 4	Nortriptyline;Duloxetine;Pregabalin;Mexiletine
48	Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Chemotherapy-Induced Neuropathy	Completed	NCT00380965	Phase 4	Cesamet™ (nabilone)
49	Efficacy and Tolerability of Carbamazepine CR in Diabetic Neuropathy Pain	Completed	NCT01089855	Phase 4	Carbamazepine
50	Maintenance of Effect of Duloxetine in Patients With Diabetic Peripheral Neuropathic Pain (DPNP)	Completed	NCT00322621	Phase 4	Duloxetine

Search NIH Clinical Center for Neuropathy

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Genetic Tests for Neuropathy

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Anatomical Context for Neuropathy

MalaCards organs/tissues related to Neuropathy:

⁴¹

Testes, Skin, Heart, Bone, Brain, Eye, Kidney

The Foundational Model of Anatomy Ontology organs/tissues related to Neuropathy:

¹⁹

Nerves Or Nerve Cells

Sources

Publications for Neuropathy

Articles related to Neuropathy:

(show top 50) (show all 12171)

#	Title	Authors	Year
1	Findings from aetiological investigation of Auditory Neuropathy Spectrum Disorder in children referred to cochlear implant programs. ( 30554714 )	Rajput K...Nash R	2019
2	Cochlear implantation in children with auditory neuropathy: Lessons from Brown-Vialetto-Van Laere syndrome. ( 30332915 )	Anderson P...Bruce IA	2019
3	Differences in skin blood flow oscillations between the plantar and dorsal foot in people with diabetes mellitus and peripheral neuropathy. ( 30414870 )	Jan YK...Choi HMC	2019
4	Vasculitis and peripheral neuropathy. ( 30461543 )	Graf J...Imboden J	2019
5	Leber's hereditary optic neuropathy: Shifting our attention to the macula. ( 30505979 )	Asanad S...Sadun AA	2019
6	The role of skin biopsy in differentiating small-fiber neuropathy from ganglionopathy. ( 30520237 )		2019
7	Expression of pathogenic SCN9A mutations in the zebrafish: A model to study small-fiber neuropathy. ( 30316835 )	Eijkenboom I...PROPANE Study Group	2019
8	Response to Crevenna and Ashbury, Vallance and Bolam, and Crevenna and Keilani regarding the effects of exercise on chemotherapy-induced peripheral neuropathy. ( 30374766 )	Kleckner IR...Mustian KM	2019
9	Letter to the editor-comments on Kleckner et al. (2018) "Effects of exercise during chemotherapy-induced peripheral neuropathy: a multicenter, randomized controlled trial". ( 30032400 )	Vallance JK...Bolam KA	2019
10	Chemotherapy-induced peripheral neuropathy-more high-quality research is needed. ( 30046880 )	Crevenna R...Keilani M	2019
11	Cure of human diabetic neuropathy by HPLC validated bark extract of Onosma echioides L. root. ( 29629826 )	Shoaib A....Siddiqui H.H.	2018
12	Hyperhomocysteinemia in bilateral anterior ischemic optic neuropathy after conventional coronary artery bypass graft: a case report. ( 29338755 )	Niro A....Alessio G.	2018
13	Different nerve ultrasound patterns in charcot-marie-tooth types and hereditary neuropathy with liability to pressure palsies. ( 28802056 )	Padua L....Briani C.	2018
14	Pseudohemangioma in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 29784095 )	Fortin E....Gaier E.D.	2018
15	Diabetic neuropathy and painful diabetic neuropathy: Cinderella complications in South East Asia. ( 29371725 )	Almuhannadi H....Malik R.A.	2018
16	Clinical and genetic features of Charcot-Marie-Tooth disease 2F and hereditary motor neuropathy 2B in Japan. ( 29381233 )	Tanabe H....Takashima H.	2018
17	Diffusion-Weighted Imaging Changes in a Child With Posterior Ischemic Optic Neuropathy. ( 29859720 )	Harrar D.B....Rivkin M.J.	2018
18	Causes of peroneal neuropathy associated with orthopaedic leg lengthening in different canine models. ( 29802558 )	Shchudlo N.A....Yemanov A.A.	2018
19	Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. ( 29953490 )	Gaier E.D....Miller J.B.	2018
20	Spinobulbar muscular atrophy combined with atypical hereditary neuropathy with liability to pressure palsy. ( 29137918 )	Choi K....Sung J.J.	2018
21	Genetic Testing for Wolfram Syndrome Mutations in a Sample of 71 Patients with Hereditary Optic Neuropathy and Negative Genetic Test Results for <i>OPA1/OPA3/LHON</i>. ( 29563951 )	Galvez-Ruiz A....Schatz P.	2018
22	Could Buerger's disease cause nonarteritic anterior ischemic optic neuropathy?: a rare case report. ( 29623524 )	Korkmaz A....Kusbeci T.	2018
23	Sciatic neuropathy and rhabdomyolysis after carbon monoxide intoxication: A case report. ( 29879074 )	Lee H.D....Lee K.H.	2018
24	Safety of rAAV2/2-ND4 Gene Therapy for Leber Hereditary Optic Neuropathy. ( 29426586 )	Vignal C....Sahel J.A.	2018
25	Analysis of Visual Field Defects Obtained with Semiautomated Kinetic Perimetry in Patients with Leber Hereditary Optic Neuropathy. ( 29750122 )	Nowomiejska K....Rejdak R.	2018
26	Long-term Peripheral Neuropathy in Breast Cancer Patients Treated With Adjuvant Chemotherapy: NRG Oncology/NSABP B-30. ( 28954297 )	Bandos H....Ganz P.A.	2018
27	Topiramate-induced Neuropathy Mimicking Carpal Tunnel Syndrome: A Case Report. ( 29430500 )	Gandhi J.S....Rivlin M.	2018
28	Single fiber F-waves compared with conventional surface F-waves, and their utility in detecting early diabetic neuropathy. ( 29975798 )	Kamel J....Roberts L.	2018
29	Longterm Reversal of Severe Visual Loss by Mitochondrial Gene Transfer in a Mouse Model of Leber Hereditary Optic Neuropathy. ( 29615737 )	Yu H....Guy J.	2018
30	Insights into the Contribution of Voltage-Gated Sodium Channel 1.7 to Paclitaxel-Induced Neuropathy. ( 29973416 )	Bernal L.	2018
31	The first case of hourglass-like constriction neuropathy of a digital nerve. ( 29449158 )	El Sayed L....Goubier J.N.	2018
32	Altered TDP-43-dependent splicing in HSPB8-related distal hereditary motor neuropathy and myofibrillar myopathy. ( 29029362 )	Cortese A....Pareyson D.	2018
33	Late-onset Leber hereditary optic neuropathy presenting after intraocular surgery. ( 29784175 )	Sergouniotis P.I....Ansons A.	2018
34	Chemotherapy-Associated Peripheral Neuropathy in Patients With Early-Stage Breast Cancer: A Systematic Review. ( 28954296 )	Rivera D.R....Melnikow J.	2018
35	Evaluation of Dizziness Handicap in Adolescents and Adults with Auditory Neuropathy Spectrum Disorder. ( 29371893 )	Prabhu P....Jamuar P.	2018
36	Neuroprotective effect of duloxetine in a mouse model of diabetic neuropathy: Role of glia suppressing mechanisms. ( 29763613 )	Tawfik M.K....Zaitone S.A.	2018
37	The CAPOS mutation in ATP1A3 alters Na/K-ATPase function and results in auditory neuropathy which has implications for management. ( 29305691 )	TranebjA	2018
38	Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients. ( 29896405 )	de Moraes C.G....Maestre G.E.	2018
39	Wernicke-Korsakoff syndrome complicated by subacute beriberi neuropathy in an alcoholic patient. ( 29128624 )	Di Marco S....Cosentino G.	2018
40	A patient with peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and severe hypoganglionosis associated with a novel SOX10 mutation. ( 29681101 )	Akutsu Y....Inoue K.	2018
41	Comparison of peripheral nerve blockade characteristics between non-diabetic patients and patients suffering from diabetic neuropathy: a prospective cohort study. ( 29858510 )	Baeriswyl M....Albrecht E.	2018
42	Incidence and disease burden of chemotherapy-induced peripheral neuropathy in a population-based cohort. ( 29439162 )	Shah A....Staff N.P.	2018
43	Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic neuropathy. ( 29273519 )	Yerra V.G....Kumar A.	2018
44	Cardiovascular Autonomic Neuropathy and Glucose Variability in Patients With Type 1 Diabetes: Is There an Association? ( 29725320 )	Nyiraty S....VA!rkonyi T.	2018
45	Ulnar neuropathy at wrist: entrapment at a very &quot;congested&quot; site. ( 29779137 )	Coraci D....Padua L.	2018
46	Cerebral Biochemical Effect of Pregabalin in Patients with Painful Diabetic Neuropathy: A Randomized Controlled Trial. ( 29951977 )	De Jaeger M....Moens M.	2018
47	Optimal Measurement Level and Ulnar Nerve Cross-Sectional Area Cutoff Threshold for Identifying Ulnar Neuropathy at the Elbow by MRI and Ultrasonography. ( 29622409 )	Terayama Y....Kato H.	2018
48	Feasibility Trial of Treatment of Ulnar Neuropathy at the Elbow Using a Specifically Designed Splint. ( 29912777 )	Michell A.W....Sesath H.G.R.	2018
49	Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation. ( 29981335 )	Mulpuri Y....Spigelman I.	2018
50	Feasibility and effectiveness of electrochemical dermal conductance measurement for the screening of diabetic neuropathy in primary care. DECODING Study (Dermal Electrochemical Conductance in Diabetic Neuropathy). Rationale and design. ( 29768354 )	CabrAc J.J....Flores-Mateo G.	2018

Sources

Genes for Neuropathy

Genes related to Neuropathy (0 elite genes):

(show all 44)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	DLX6-AS1	DLX6 Antisense RNA 1	RNA Gene	150	Experimental evidence: Regulation ³⁹	16705037
2	GJB1	Gap Junction Protein Beta 1	Protein Coding	65.81	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Variants (show sections)
3	MPZ	Myelin Protein Zero	Protein Coding	65.54	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Variants (show sections)
4	GAN	Gigaxonin	Protein Coding	63.89	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Variants (show sections)
5	WNK1	WNK Lysine Deficient Protein Kinase 1	Protein Coding	62.76	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Variants (show sections)
6	SPTLC1	Serine Palmitoyltransferase Long Chain Base Subunit 1	Protein Coding	62.29	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Variants (show sections)
7	PNPLA6	Patatin Like Phospholipase Domain Containing 6	Protein Coding	62	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Proteins Variants (show sections)
8	GDAP1	Ganglioside Induced Differentiation Associated Protein 1	Protein Coding	61.86	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Variants (show sections)
9	AIFM1	Apoptosis Inducing Factor Mitochondria Associated 1	Protein Coding	58.9	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Variants (show sections)
10	DIAPH3	Diaphanous Related Formin 3	Protein Coding	57.42	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Variants (show sections)
11	MFN2	Mitofusin 2	Protein Coding	55.1	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
12	PMP22	Peripheral Myelin Protein 22	Protein Coding	54.78	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
13	MT-ND4	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 4	Protein Coding	53.9	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Variants (show sections)
14	KIF1A	Kinesin Family Member 1A	Protein Coding	53.11	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
15	NGF	Nerve Growth Factor	Protein Coding	53	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
16	SPTLC2	Serine Palmitoyltransferase Long Chain Base Subunit 2	Protein Coding	52.65	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
17	SCN11A	Sodium Voltage-Gated Channel Alpha Subunit 11	Protein Coding	52.34	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
18	POLG	DNA Polymerase Gamma, Catalytic Subunit	Protein Coding	52.31	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
19	GP1BA	Glycoprotein Ib Platelet Subunit Alpha	Protein Coding	51.73	GeneCards inferred via : Disorders Publications Summaries Proteins Variants (show sections)
20	CCT5	Chaperonin Containing TCP1 Subunit 5	Protein Coding	51.03	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
21	RETREG1	Reticulophagy Regulator 1	Protein Coding	50.8	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
22	PRX	Periaxin	Protein Coding	40.77	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
23	DNMT1	DNA Methyltransferase 1	Protein Coding	40.47	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
24	SLC12A6	Solute Carrier Family 12 Member 6	Protein Coding	39.84	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries (show sections)
25	SLC25A46	Solute Carrier Family 25 Member 46	Protein Coding	39.72	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
26	TDP1	Tyrosyl-DNA Phosphodiesterase 1	Protein Coding	39.38	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
27	HINT1	Histidine Triad Nucleotide Binding Protein 1	Protein Coding	39.33	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
28	CTDP1	CTD Phosphatase Subunit 1	Protein Coding	39.31	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
29	ATL3	Atlastin GTPase 3	Protein Coding	39.3	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
30	SCN9A	Sodium Voltage-Gated Channel Alpha Subunit 9	Protein Coding	35.09	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
31	DNM2	Dynamin 2	Protein Coding	33.67	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Variants (show sections)
32	GARS	Glycyl-TRNA Synthetase	Protein Coding	33.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Gene name Variants (show sections)
33	EGR2	Early Growth Response 2	Protein Coding	33.15	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
34	MT-ND6	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6	Protein Coding	33.05	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
35	TWNK	Twinkle MtDNA Helicase	Protein Coding	32.14	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
36	OTOF	Otoferlin	Protein Coding	32.06	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
37	SNAP29	Synaptosome Associated Protein 29	Protein Coding	31.41	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
38	ELP1	Elongator Complex Protein 1	Protein Coding	31.21	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Gene name Variants (show sections)
39	DST	Dystonin	Protein Coding	31.17	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
40	SBF2	SET Binding Factor 2	Protein Coding	31.15	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Gene name Variants (show sections)
41	MT-ATP6	Mitochondrially Encoded ATP Synthase Membrane Subunit 6	Protein Coding	31.05	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
42	TFG	TRK-Fused Gene	Protein Coding	31.03	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
43	MT-ND1	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 1	Protein Coding	31	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
44	MT-ND5	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 5	Protein Coding	30.48	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)

Sources

Variations for Neuropathy

Copy number variations for Neuropathy from CNVD:

⁷

#	CNVD ID	Chromosom	Start	End	Type	Gene Symbol	CNVD Disease
1	107544	17	15900000	22100000	Microdeletion		Neuropathy
2	107574	17	16000000	22200000	Copy number		Neuropathy
3	216423	6	92100000	98700000	Microdeletion	EPHA7	Neuropathy

Sources

Expression for Neuropathy

Search GEO for disease gene expression data for Neuropathy.

Sources

Pathways for Neuropathy

Pathways related to Neuropathy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neural Crest Differentiation ¹	10.81	GJB1 MPZ PMP22

Sources

GO Terms for Neuropathy

Cellular components related to Neuropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine C-palmitoyltransferase complex	GO:0017059	8.62	SPTLC1 SPTLC2

Biological processes related to Neuropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peripheral nervous system development	GO:0007422	9.4	NGF PMP22
2	ceramide biosynthetic process	GO:0046513	9.37	SPTLC1 SPTLC2
3	mitochondrial fusion	GO:0008053	9.32	GDAP1 MFN2
4	sphingosine biosynthetic process	GO:0046512	9.26	SPTLC1 SPTLC2
5	sphingomyelin biosynthetic process	GO:0006686	9.16	SPTLC1 SPTLC2
6	positive regulation of lipophagy	GO:1904504	8.96	SPTLC1 SPTLC2
7	sphinganine biosynthetic process	GO:0046511	8.62	SPTLC1 SPTLC2

Molecular functions related to Neuropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine C-palmitoyltransferase activity	GO:0004758	8.62	SPTLC1 SPTLC2

Sources

Sources for Neuropathy

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia