Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: NRP001
MIFTS: 63

Neuropathy

Categories: Immune diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Neuropathy

About this section

MalaCards integrated aliases for Neuropathy:

Name: Neuropathy 12 15 41 17 74
Peripheral Neuropathy 12 15 74

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:870
NCIt 51 C4731
SNOMED-CT 69 42658009
ICD10 34 G62.9
Sources

Summaries for Neuropathy

About this section
Disease Ontology : 12 A nervous system disease that is located in nerves or nerve cells.

MalaCards based summary : Neuropathy, also known as peripheral neuropathy, is related to neuropathy, hereditary sensory, type ie and neuropathy, hereditary, with liability to pressure palsies, and has symptoms including seizures, tremor and back pain. An important gene associated with Neuropathy is DLX6-AS1 (DLX6 Antisense RNA 1), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Pregabalin and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include testes, spinal cord and skin, and related phenotypes are behavior/neurological and cellular

Sources

Related Diseases for Neuropathy

About this section

Diseases in the Neuropathy family:

Autoimmune Neuropathy Hereditary Type 1 Neuropathy
Hereditary Type 2 Neuropathy Neuropathy - Hereditary

Diseases related to Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1826)
# Related Disease Score Top Affiliating Genes
1 neuropathy, hereditary sensory, type ie 34.4 SPTLC1 SPTLC2
2 neuropathy, hereditary, with liability to pressure palsies 34.4 GDAP1 GJB1 MFN2 MPZ PMP22
3 hypertrophic neuropathy of dejerine-sottas 34.3 GDAP1 GJB1 MPZ PMP22
4 neuropathy, hereditary sensory and autonomic, type ic 34.2 SPTLC1 SPTLC2
5 neuropathy - hereditary 34.1 PMP22 SCN11A SPTLC1
6 hereditary sensory neuropathy 34.1 KIF1A NGF SPTLC1 SPTLC2 WNK1
7 autonomic neuropathy 34.1 KIF1A NGF SPTLC1 SPTLC2 WNK1
8 hereditary sensory and autonomic neuropathy type 1 34.1 SPTLC1 SPTLC2
9 hereditary motor and sensory neuropathy, type iic 34.0 GDAP1 GJB1 MFN2 MPZ
10 charcot-marie-tooth disease, x-linked dominant, 1 33.9 GJB1 MPZ PMP22
11 charcot-marie-tooth disease, demyelinating, type 1b 33.8 GJB1 MPZ PMP22
12 charcot-marie-tooth hereditary neuropathy 33.8 MPZ PMP22
13 charcot-marie-tooth disease, demyelinating, type 1c 33.7 GJB1 MPZ PMP22
14 congenital hypomyelination neuropathy 33.7 MPZ PMP22
15 motor peripheral neuropathy 33.7 GJB1 MFN2 MPZ PMP22 SLC12A6
16 charcot-marie-tooth disease, axonal, type 2b 33.7 GJB1 MPZ PMP22 SPTLC1
17 charcot-marie-tooth disease, type 4d 33.7 GDAP1 GJB1 MFN2
18 charcot-marie-tooth disease, demyelinating, type 1d 33.7 GJB1 MPZ PMP22
19 sensory peripheral neuropathy 33.7 GDAP1 GJB1 MFN2 MPZ NGF PMP22
20 charcot-marie-tooth disease, demyelinating, type 1f 33.6 GJB1 MPZ PMP22
21 charcot-marie-tooth disease, demyelinating, type 1a 33.6 GDAP1 GJB1 MFN2 MPZ PMP22
22 charcot-marie-tooth disease, axonal, type 2d 33.6 GJB1 MPZ PMP22
23 sensory neuropathy type 1 33.6 GJB1 SPTLC1
24 axonal neuropathy 33.5 GAN GDAP1 MFN2 PMP22 POLG
25 charcot-marie-tooth disease and deafness 33.5 GDAP1 GJB1 MFN2 MPZ PMP22
26 charcot-marie-tooth disease, axonal, type 2e 33.4 GAN GDAP1 GJB1 MFN2 MPZ PMP22
27 charcot-marie-tooth disease, axonal, type 2f 33.4 GJB1 MPZ
28 charcot-marie-tooth disease, axonal, type 2k 33.3 GDAP1 KIF1A MFN2
29 charcot-marie-tooth disease 33.0 AIFM1 GAN GDAP1 GJB1 MFN2 MPZ
30 roussy-levy hereditary areflexic dystasia 32.8 MPZ PMP22
31 peripheral nervous system disease 32.8 GAN GDAP1 GJB1 MFN2 MPZ MT-ND4
32 charcot-marie-tooth disease type 2a2 32.5 GAN MFN2
33 polyneuropathy 32.3 GDAP1 MPZ PMP22 PNPLA6 POLG
34 foot drop 32.3 MPZ PMP22
35 myoclonic epilepsy associated with ragged-red fibers 32.0 GDAP1 MT-ND4 POLG
36 spinocerebellar degeneration 31.8 PNPLA6 POLG
37 cranial nerve disease 31.6 MFN2 MT-ND4 POLG
38 tooth disease 31.2 GDAP1 GJB1 MFN2 MPZ PMP22
39 amyotrophic neuralgia 30.6 GJB1 PMP22
40 chronic inflammatory demyelinating polyradiculoneuropathy 30.1 MPZ PMP22
41 neurogenic arthropathy 29.8 NGF SPTLC1
42 neuropathy, hereditary sensory and autonomic, type iia 12.6
43 neuropathy, congenital hypomyelinating, 1, autosomal recessive 12.5
44 neuropathy, hereditary sensory and autonomic, type v 12.5
45 neuropathy, hereditary motor and sensory, type via 12.5
46 nonarteritic anterior ischemic optic neuropathy 12.5
47 neuromyotonia and axonal neuropathy, autosomal recessive 12.4
48 diabetic neuropathy 12.4
49 neuropathy, hereditary sensory and autonomic, type vii 12.4
50 neuropathy, hereditary sensory and autonomic, type vi 12.4

Graphical network of the top 20 diseases related to Neuropathy:



Diseases related to Neuropathy
Sources

Symptoms & Phenotypes for Neuropathy

About this section

UMLS symptoms related to Neuropathy:


seizures, tremor, back pain, pain, headache, syncope, hemiparesis, chronic pain, sciatica, vertigo/dizziness, sleeplessness, neuralgia, neurologic symptoms, atypical facial pain

MGI Mouse Phenotypes related to Neuropathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 AIFM1 GAN GDAP1 GJB1 KIF1A MFN2
2 cellular MP:0005384 10.22 AIFM1 DIAPH3 GAN GDAP1 GJB1 GP1BA
3 growth/size/body region MP:0005378 10.18 AIFM1 DIAPH3 GAN GJB1 KIF1A MFN2
4 homeostasis/metabolism MP:0005376 10.17 AIFM1 DIAPH3 GDAP1 GJB1 GP1BA MFN2
5 mortality/aging MP:0010768 10 AIFM1 DIAPH3 GAN GJB1 KIF1A MFN2
6 integument MP:0010771 9.91 AIFM1 DIAPH3 KIF1A NGF PNPLA6 POLG
7 muscle MP:0005369 9.56 AIFM1 GAN MFN2 NGF PMP22 POLG
8 nervous system MP:0003631 9.5 AIFM1 GAN GDAP1 GJB1 KIF1A MFN2
Sources

Drugs & Therapeutics for Neuropathy

About this section

Drugs for Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1136)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 148553-50-8 5486971
2
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 60142-96-3 3446
3
Stavudine Approved, Investigational Phase 4,Phase 3 3056-17-5 18283
4
Isosorbide Dinitrate Approved, Investigational Phase 4,Phase 3 87-33-2 6883
5
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 10102-43-9 145068
6
AT-101 Approved, Investigational Phase 4,Phase 3 90141-22-3, 652-67-5 12597
7
Timolol Approved Phase 4,Phase 3,Phase 1,Not Applicable 26839-75-8 5478 33624
8
Dorzolamide Approved Phase 4,Not Applicable 120279-96-1 5284549 3154
9
Histamine Approved, Investigational Phase 4,Phase 2,Not Applicable 51-45-6 774
10
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
11
Colistin Approved Phase 4 1066-17-7, 1264-72-8 5311054
12
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
13
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 57-27-2 5288826
14
Ibuprofen Approved Phase 4,Phase 2,Phase 3,Not Applicable 15687-27-1 3672
15
Saxagliptin Approved Phase 4,Not Applicable 361442-04-8 11243969
16
Metronidazole Approved Phase 4,Phase 3,Phase 2 443-48-1 4173
17
Piperacillin Approved Phase 4,Phase 3 66258-76-2 43672
18
Linezolid Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 165800-03-3 441401
19
Levofloxacin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 100986-85-4 149096
20
Tazobactam Approved Phase 4,Phase 3 89786-04-9 123630
21
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 26787-78-0 33613
22
Clindamycin Approved, Vet_approved Phase 4,Not Applicable 18323-44-9 29029
23
Ofloxacin Approved Phase 4,Phase 2,Phase 3,Not Applicable 82419-36-1 4583
24
Aztreonam Approved Phase 4 78110-38-0 5742832 5362041
25
Imipramine Approved Phase 4 50-49-7 3696
26
Dopamine Approved Phase 4,Phase 3,Phase 2,Not Applicable 62-31-7, 51-61-6 681
27
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
28
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 38396-39-3, 2180-92-9 2474
29
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
30
Etoricoxib Approved, Investigational Phase 4,Phase 2 202409-33-4 123619
31
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
32
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 378-44-9 9782
33
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 6740-88-1 3821
34
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable 84057-95-4 175805 71273
35
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
36
Ondansetron Approved Phase 4,Phase 1,Not Applicable 99614-02-5 4595
37
Capsaicin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 404-86-4 1548943
38
Methylcobalamin Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 13422-55-4
39
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2,Not Applicable 13422-51-0 15589840 11953898
40
leucovorin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
41
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 27203-92-5 33741
42
Nabilone Approved, Investigational Phase 4,Phase 3,Phase 2 51022-71-0 5284592
43
Naloxone Approved, Vet_approved Phase 4,Phase 2 465-65-6 5284596
44
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 76-42-6 5284603
45
Nortriptyline Approved Phase 4,Phase 2,Not Applicable 72-69-5 4543
46
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 298-46-4 2554
47
tannic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1401-55-4
48
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
49
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
50
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 302-25-0

Interventional clinical trials:

(show top 50) (show all 3944)
# Name Status NCT ID Phase Drugs
1 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy Unknown status NCT00123136 Phase 4
2 Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy Unknown status NCT01770964 Phase 4 Pregabalin;placebo
3 Omega-3 Fatty Acids and Chemotherapy-induced Neuropathy and Inflammation in Breast Cancer Unknown status NCT01049295 Phase 4
4 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
5 IVIg for Demyelination in Diabetes Mellitus Unknown status NCT02372149 Phase 4 10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
6 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
7 Evaluation of Viral Efficacy and Safety of a Reduced Dose of Stavudine (d4T): THE PHOENIX STUDY Unknown status NCT00235222 Phase 4 stavudine
8 Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Unknown status NCT00446810 Phase 4 Benfotiamine;Placebo
9 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
10 Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences. Unknown status NCT02033057 Phase 4
11 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4 Timolol & Dorzolamide
12 Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4 pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
13 Colistin Pharmacokinetics in Continuous Renal Replacement Therapy Unknown status NCT02081560 Phase 4 Colistin
14 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
15 Ultrasound-guided Caudal or Interlaminar Corticosteroid Epidural Injection for Sciatica Unknown status NCT02897336 Phase 4
16 IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia Unknown status NCT02504996 Phase 4 Paracetamol;morphine;Placebo
17 Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department Unknown status NCT02777320 Phase 4 paracetamol;Ibuprofen
18 Maggot Debridement Therapy Versus Conventional Dressing Therapy to Treat Diabetic Foot Ulcers Unknown status NCT02816749 Phase 4
19 Dipeptidyl Peptidase 4 Inhibition Facilitate Healing of Diabetic Ulcers Unknown status NCT02742233 Phase 4 saxagliptin;placebo
20 A Comparison of TCC-EZ Using Human Amnion Allograft vs TCC-EZ and Standard Wound Care in Treating Diabetic Foot Ulcers. Unknown status NCT02344329 Phase 4
21 A Comparative Efficacy Study of DermaPureâ„¢ to Treat Diabetic Foot Ulcers Unknown status NCT02081352 Phase 4
22 Efficacy and Safety of Garamycin® Sponge (Gentamicin-Collagen Sponge) in Diabetic Patients With a Moderate or Severe Foot Ulcer Infection Unknown status NCT01951768 Phase 4 Garamycin Sponge (Gentamicin-Collagen sponge);Systemic Antibiotic
23 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
24 A Post-marketing Evaluation of a Compound Traditional Chinese Herbal Medicine, Qishe Pill, on Cervical Radiculopathy Unknown status NCT01875562 Phase 4 Qishe Pill
25 Imipramine and Pregabalin Combination in Painful Polyneuropathy Unknown status NCT01047488 Phase 4 Imipramine;Pregabalin;Imipramine, pregabalin;Placebo
26 Determination of the Antidepressant Duloxetine in Plasma to Improve the Knowledge of the Analgesic Action of Antidepressants on Chronic Neuropathic Pain Unknown status NCT02846701 Phase 4 duloxetine
27 Comparison of Two Pain-treatment Techniques After Cesarean Section Unknown status NCT02804126 Phase 4 Bupivacaine;Paracetamol;Metamizol;Ketoprofen;Morphine
28 Evaluation of the Efficacy, Tolerability and Safety of Etoricoxib (Arcoxia) in Patients With Neuropathic Pain Unknown status NCT01264237 Phase 4 Etoricoxib;Placebo
29 Transforaminal Epidural Steroid Injection With Pulsed Radiofrequency for Chronic Lumbosacral Radicular Pain Management Unknown status NCT02930057 Phase 4 Celestone;Control
30 Postoperative Analgesia in Patients With Microvascular Decompression Unknown status NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
31 Percutaneous HydroDiscectomy Compared to TESI for Radiculopathy Unknown status NCT02414698 Phase 4 TESI
32 Preventing Pain After Heart Surgery Unknown status NCT01480765 Phase 4 Pregabalin;Ketamine infusion;Placebo capsules;Placebo infusion
33 Conservative Versus Aggressive Discectomy for Primary Disc Herniation With Radiculopathy Unknown status NCT01204008 Phase 4
34 Qutenza for Critical Ischaemia in End Stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
35 Effects of Pregabalin on Mechanical Hyperalgesia Unknown status NCT00310583 Phase 4 Pregabalin
36 Pregabalin for the Treatment and Prevention of Spinal Cord Injury Neuropathic Pain Unknown status NCT01479556 Phase 4 Pregabalin;Placebo
37 Safety and Efficacy of Mecobalamin Injection in Peripheral Neuropathies Patients (Study JGAZSY091109) Completed NCT01192113 Phase 4 Mecobalamin IV Injection;Mecobalamin IM injection;Mecobalamin IV or IM injection
38 The Effect of α-lipoic Acid Treatment in Patient With Cardiac Autonomic Neuropathy Completed NCT02056366 Phase 4 α-lipoic acid
39 Efficacy of γ-linolenic Acid and Thioctic Acid in Patients With Diabetic Neuropathy Completed NCT03914404 Phase 4 γ-linoleic acid and placebo(Thioctic Acid);Thioctic Acid and placebo(γ-linoleic acid)
40 Frequency Modulated Neural Stimulation (FREMS) in Symptomatic Diabetic Neuropathy Completed NCT01628627 Phase 4
41 A Randomized Double-Blind Study Testing the Effects of Pregabalin on Diabetic Neuropathy Completed NCT00573261 Phase 4 Pregabalin;Placebo
42 Effect of Pulsing Electrical Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study Completed NCT00614341 Phase 4
43 Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN) Completed NCT00726713 Phase 4
44 Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
45 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
46 A Study on the Efficacy and Safety of Gabapentin in the Treatment of Patients With Painful Diabetic Neuropathy Completed NCT00644748 Phase 4 gabapentin
47 A Study to Compare Safety and Efficacy of Tramadol Hydrochloride/Acetaminophen With Gabapentin in Participants With Diabetic Neuropathy Completed NCT00634543 Phase 4 Tramadol hydrochloride/ Acetaminophen;Gabapentin
48 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
49 Evaluation of the Efficacy of Cesametâ„¢ for the Treatment of Pain in Patients With Diabetic Peripheral Neuropathy Completed NCT00380913 Phase 4 Cesametâ„¢ (nabilone)
50 Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy Completed NCT00159679 Phase 4 Pregabalin

Search NIH Clinical Center for Neuropathy

Sources

Genetic Tests for Neuropathy

About this section
Sources

Anatomical Context for Neuropathy

About this section

MalaCards organs/tissues related to Neuropathy:

42
Testes, Spinal Cord, Skin, Brain, Bone, Eye, Kidney

The Foundational Model of Anatomy Ontology organs/tissues related to Neuropathy:

20
Nerves Or Nerve Cells
Sources

Publications for Neuropathy

About this section

Articles related to Neuropathy:

(show top 50) (show all 16917)
# Title Authors Year
1
Erratum to "Peripheral neuropathy in patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency - A follow-up EMG study of 12 patients" [Eur J Paediatr Neuro 20 (2016) 38-44]. ( 30642532 )
2019
2
An overlapping case of Bickerstaff brainstem encephalitis and acute motor axonal neuropathy variant of Guillain-Barré syndrome associated with systemic lupus erythematosus. ( 30444497 )
2019
3
Pulse-steroid therapy in a 37-year-old man with acute motor and sensory axonal neuropathy: A case report. ( 30899482 )
2019
4
A rare mimic of acute stroke: rapidly progressing Miller-Fisher Syndrome to acute motor and sensory axonal neuropathy variant of Guillain-Barre Syndrome. ( 30936342 )
2019
5
Postural sway, falls, and self-reported neuropathy in aging female cancer survivors. ( 30716669 )
2019
6
Re: Melgarejo et al.: Glaucomatous optic neuropathy associated with nocturnal dip in blood pressure: findings from Maracaibo Aging Study (Ophthalmology. 2018;125:807-814). ( 30683183 )
2019
7
Skin nerve pathology: Biomarkers of premanifest and manifest amyloid neuropathy. ( 30737830 )
2019
8
6MWT performance correlates with peripheral neuropathy but not with cardiac involvement in patients with hereditary transthyretin amyloidosis (hATTR). ( 30718023 )
2019
9
Demyelinating Neuropathy in a Patient Treated With Revusiran for Transthyretin (Thr60Ala) Amyloidosis. ( 30801482 )
2019
10
Screening for Fabry disease and Hereditary ATTR amyloidosis in idiopathic small-fiber and mixed neuropathy. ( 30246259 )
2019
11
Image Gallery: Acquired anhidrosis associated with alcohol-related peripheral neuropathy, a potential cause of anhidrosis due to reduced innervation of eccrine glands. ( 30714116 )
2019
12
Pachymeningitis with optic neuropathy associated with extrapulmonary tuberculosis and secondary antiphospholipid syndrome. ( 30685445 )
2019
13
A rare cause of progressive neuropathy: Arachnoiditis ossificans. ( 30706872 )
2019
14
Giant cell arteritis related arteritic anterior ischemic optic neuropathy: Clinico-pathological correlation. ( 30574925 )
2019
15
Characterization of retinal microvasculature in acute non-arteritic anterior ischemic optic neuropathy using the retinal functional imager: a prospective case series. ( 30675495 )
2019
16
Systemic oxidative stress in non-arteritic anterior ischemic optic neuropathy. ( 30833666 )
2019
17
Abnormal spontaneous brain activity in patients with non-arteritic anterior ischemic optic neuropathy detected using functional magnetic resonance imaging. ( 30855358 )
2019
18
Choroidal Vascular Changes in Arteritic and Non-arteritic Anterior Ischemic Optic Neuropathy. ( 30954470 )
2019
19
Retinal Vessel Phenotype in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy. ( 31004591 )
2019
20
Methotrexate-associated primary hepatic lymphoma and cranial neuropathy in a patient with rheumatoid arthritis: A case report with clinical follow-up over a 7-year period. ( 31027052 )
2019
21
Prevalence and patterns of peripheral neuropathy in patients of rheumatoid arthritis. ( 30911476 )
2019
22
Clinical characteristics of rheumatoid arthritis patients with peripheral neuropathy and potential related risk factors. ( 30911944 )
2019
23
Role of miR-9-5p in preventing peripheral neuropathy in patients with rheumatoid arthritis by targeting REST/miR-132 pathway. ( 30456455 )
2019
24
The Difficulty of Diagnosing Invasive Aspergillosis Initially Manifesting as Optic Neuropathy. ( 30792652 )
2019
25
Findings from aetiological investigation of Auditory Neuropathy Spectrum Disorder in children referred to cochlear implant programs. ( 30554714 )
2019
26
Is tinnitus a major concern in individuals with auditory neuropathy spectrum disorder? - Questionnaire based study. ( 30775694 )
2019
27
GJB2 c.235delC variant associated with autosomal recessive nonsyndromic hearing loss and auditory neuropathy spectrum disorder. ( 30816908 )
2019
28
Effect of acoustic features on discrimination ability in individuals with auditory neuropathy spectrum disorder: an electrophysiological and behavioral study. ( 30937559 )
2019
29
Relationship research between auditory neuropathy spectrum disorder and exchange transfusion in neonates with severe hyperbilirubinemia. ( 31103744 )
2019
30
Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet. ( 30793549 )
2019
31
An update on the diagnosis and treatment of diabetic somatic and autonomic neuropathy. ( 30828432 )
2019
32
Is our treatment in type 1 diabetes mellitus (insulin therapy models, metabolic control) optimal for preventing cardiovascular autonomic neuropathy? ( 30845344 )
2019
33
Sleep duration is a significant predictor of cardiac autonomic neuropathy in type 2 diabetes mellitus. ( 30850339 )
2019
34
Clinical factors associated with the recovery of cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus. ( 30857534 )
2019
35
Hereditary sensory and autonomic neuropathy type IC (HSAN1C) accompanied by upper motor neuron abnormalities and type II juxtafoveal retinal telangiectasias. ( 30866134 )
2019
36
Clinical utility of SUDOSCAN in predicting autonomic neuropathy in patients with Parkinson's disease. ( 30890381 )
2019
37
Novel Insights into Sensorimotor and Cardiovascular Autonomic Neuropathy from Recent-Onset Diabetes and Population-Based Cohorts. ( 30935671 )
2019
38
A Novel Variant (Asn177Asp) in SPTLC2 Causing Hereditary Sensory Autonomic Neuropathy Type 1C. ( 30955194 )
2019
39
Treatment of Diabetic Cardiovascular Autonomic, peripheral and painful neuropathy. Focus on the treatment of Cardiovascular Autonomic Neuropathy with ACE inhibitors. ( 31109280 )
2019
40
Association of sleep apnoea syndrome and autonomic neuropathy in type 1 diabetes. ( 29169926 )
2019
41
Continuous glucose monitoring defined glucose variability is associated with cardiovascular autonomic neuropathy in type 1 diabetes. ( 30345631 )
2019
42
Generalised arterial calcification in normoalbuminuric patients with type 1 diabetes with and without cardiovascular autonomic neuropathy. ( 30345796 )
2019
43
Left ventricular remodelling and cardiac chamber sizes in long-term, normoalbuminuric type 1 diabetes patients with and without cardiovascular autonomic neuropathy. ( 30355473 )
2019
44
Cardiovascular autonomic neuropathy and falls in Parkinson disease: a prospective cohort study. ( 30382389 )
2019
45
Decreased β-Cell Function is Associated with Cardiovascular Autonomic Neuropathy in Chinese Patients Newly Diagnosed with Type 2 Diabetes. ( 30430334 )
2019
46
Suppression Failure of Cortisol Secretion by Dexamethasone May Occur in Glucagon-like Peptide-1 Receptor Agonist-treated Patients with Diabetic Autonomic Neuropathy. ( 30568127 )
2019
47
Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes. ( 30599773 )
2019
48
Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. ( 30626650 )
2019
49
Diagnosis of cardiovascular autonomic neuropathy in diabetes: as simple as possible, but not simpler? An answer. ( 30734866 )
2019
50
Diagnosis of cardiovascular autonomic neuropathy in diabetes: as simple as possible, but not simpler? ( 30734867 )
2019
Sources

Variations for Neuropathy

About this section

Copy number variations for Neuropathy from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 107544 17 15900000 22100000 Microdeletion Neuropathy
2 107574 17 16000000 22200000 Copy number Neuropathy
3 216423 6 92100000 98700000 Microdeletion EPHA7 Neuropathy
Sources

Expression for Neuropathy

About this section
Search GEO for disease gene expression data for Neuropathy.
Sources

Pathways for Neuropathy

About this section

Pathways related to Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neural Crest Differentiation 1
10.81 GJB1 MPZ PMP22
Sources

GO Terms for Neuropathy

About this section

Cellular components related to Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine C-palmitoyltransferase complex GO:0017059 8.62 SPTLC1 SPTLC2

Biological processes related to Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peripheral nervous system development GO:0007422 9.4 NGF PMP22
2 ceramide biosynthetic process GO:0046513 9.37 SPTLC1 SPTLC2
3 mitochondrial fusion GO:0008053 9.32 GDAP1 MFN2
4 sphingosine biosynthetic process GO:0046512 9.26 SPTLC1 SPTLC2
5 sphingomyelin biosynthetic process GO:0006686 9.16 SPTLC1 SPTLC2
6 positive regulation of lipophagy GO:1904504 8.96 SPTLC1 SPTLC2
7 sphinganine biosynthetic process GO:0046511 8.62 SPTLC1 SPTLC2

Molecular functions related to Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine C-palmitoyltransferase activity GO:0004758 8.62 SPTLC1 SPTLC2
Sources

Sources for Neuropathy

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy