MCID: NRP001
MIFTS: 62

Neuropathy

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Neuropathy

MalaCards integrated aliases for Neuropathy:

Name: Neuropathy 12 15 40 73
Peripheral Neuropathy 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:870
ICD10 33 G62.9
NCIt 50 C4731
SNOMED-CT 68 42658009

Summaries for Neuropathy

Disease Ontology : 12 A nervous system disease that is located in nerves or nerve cells.

MalaCards based summary : Neuropathy, also known as peripheral neuropathy, is related to neuropathy, hereditary, with liability to pressure palsies and neuropathy, hereditary sensory, type ie, and has symptoms including seizures, tremor and back pain. An important gene associated with Neuropathy is DLX6-AS1 (DLX6 Antisense RNA 1), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Pregabalin and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and heart, and related phenotypes are behavior/neurological and cellular

Related Diseases for Neuropathy

Diseases in the Neuropathy family:

Autoimmune Neuropathy Hereditary Type 1 Neuropathy
Hereditary Type 2 Neuropathy Neuropathy - Hereditary

Diseases related to Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1609)
# Related Disease Score Top Affiliating Genes
1 neuropathy, hereditary, with liability to pressure palsies 34.1 GDAP1 GJB1 MFN2 MPZ PMP22
2 neuropathy, hereditary sensory, type ie 34.1 SPTLC1 SPTLC2
3 neuropathy, congenital hypomyelinating or amyelinating, autosomal recessive 34.1 GDAP1 GJB1 MFN2 MPZ PMP22
4 hypertrophic neuropathy of dejerine-sottas 34.0 GDAP1 GJB1 MPZ PMP22
5 neuropathy, hereditary sensory and autonomic, type ic 33.9 SPTLC1 SPTLC2
6 hereditary sensory and autonomic neuropathy type 1 33.8 SPTLC1 SPTLC2
7 hereditary sensory neuropathy 33.8 KIF1A NGF SPTLC1 SPTLC2 WNK1
8 autonomic neuropathy 33.8 KIF1A NGF SPTLC1 SPTLC2 WNK1
9 neuropathy - hereditary 33.8 MPZ PMP22 SCN11A SPTLC1
10 hereditary motor and sensory neuropathy, type iic 33.8 GDAP1 GJB1 MFN2 MPZ
11 sensory peripheral neuropathy 33.7 GDAP1 GJB1 MFN2 MPZ NGF PMP22
12 motor peripheral neuropathy 33.6 GJB1 MFN2 MPZ PMP22
13 charcot-marie-tooth disease, demyelinating, type 1b 33.5 GJB1 MPZ PMP22
14 charcot-marie-tooth hereditary neuropathy 33.5 MPZ PMP22
15 charcot-marie-tooth disease, axonal, type 2e 33.5 GAN GDAP1 GJB1 MFN2 MPZ PMP22
16 charcot-marie-tooth disease, axonal, type 2b 33.4 GJB1 MPZ PMP22 SPTLC1
17 charcot-marie-tooth disease, demyelinating, type 1c 33.4 GJB1 MPZ PMP22
18 congenital hypomyelination neuropathy 33.4 MPZ PMP22
19 charcot-marie-tooth disease, x-linked dominant, 1 33.4 GJB1 MPZ PMP22
20 axonal neuropathy 33.3 GAN GDAP1 MFN2 PMP22 POLG
21 charcot-marie-tooth disease and deafness 33.3 GDAP1 GJB1 MFN2 MPZ PMP22
22 sensory neuropathy type 1 33.2 GJB1 SPTLC1
23 charcot-marie-tooth disease, type 4d 33.2 GDAP1 GJB1 MFN2
24 charcot-marie-tooth disease, demyelinating, type 1d 33.2 GJB1 MPZ PMP22
25 charcot-marie-tooth disease, axonal, type 2f 33.2 GJB1 MPZ
26 charcot-marie-tooth disease, demyelinating, type 1a 33.1 GDAP1 GJB1 MFN2 MPZ PMP22
27 charcot-marie-tooth disease, demyelinating, type 1f 33.1 GJB1 MPZ PMP22
28 charcot-marie-tooth disease, axonal, type 2d 33.1 GJB1 MPZ PMP22
29 charcot-marie-tooth disease, axonal, type 2k 33.1 GDAP1 KIF1A MFN2
30 peripheral nervous system disease 33.0 GAN GDAP1 GJB1 MFN2 MPZ MT-ND4
31 charcot-marie-tooth disease 32.9 AIFM1 GAN GDAP1 GJB1 MFN2 MPZ
32 roussy-levy hereditary areflexic dystasia 32.5 MPZ PMP22
33 charcot-marie-tooth disease type 2a2 32.2 GAN MFN2
34 polyneuropathy 32.1 GDAP1 MPZ PMP22 PNPLA6 POLG
35 hereditary spastic paraplegia 32.1 CCT5 GAN KIF1A PNPLA6
36 foot drop 32.0 MPZ PMP22
37 spinocerebellar degeneration 31.7 PNPLA6 POLG
38 cranial nerve disease 31.3 MFN2 MT-ND4 POLG
39 myoclonic epilepsy associated with ragged-red fibers 31.3 GDAP1 MT-ND4 POLG
40 tooth disease 31.0 GDAP1 GJB1 MFN2 MPZ PMP22
41 amyotrophic neuralgia 30.3 GJB1 PMP22
42 chronic inflammatory demyelinating polyradiculoneuropathy 30.0 MPZ PMP22
43 neurogenic arthropathy 29.7 NGF SPTLC1
44 neuropathy, hereditary sensory and autonomic, type iia 12.5
45 neuropathy, hereditary sensory and autonomic, type v 12.4
46 nonarteritic anterior ischemic optic neuropathy 12.4
47 neuromyotonia and axonal neuropathy, autosomal recessive 12.4
48 neuropathy, hereditary sensory and autonomic, type vii 12.4
49 neuropathy, hereditary sensory and autonomic, type vi 12.4
50 diabetic neuropathy 12.4

Graphical network of the top 20 diseases related to Neuropathy:



Diseases related to Neuropathy

Symptoms & Phenotypes for Neuropathy

UMLS symptoms related to Neuropathy:


seizures, tremor, back pain, pain, headache, syncope, hemiparesis, chronic pain, sciatica, vertigo/dizziness, sleeplessness, neuralgia, neurologic symptoms, atypical facial pain

MGI Mouse Phenotypes related to Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.21 AIFM1 GAN GDAP1 GJB1 KIF1A MFN2
2 cellular MP:0005384 10.18 AIFM1 DIAPH3 GAN GDAP1 GJB1 GP1BA
3 homeostasis/metabolism MP:0005376 10.17 AIFM1 DIAPH3 GDAP1 GJB1 GP1BA MFN2
4 growth/size/body region MP:0005378 10.15 AIFM1 DIAPH3 GAN GJB1 KIF1A MFN2
5 mortality/aging MP:0010768 10 AIFM1 DIAPH3 GAN GJB1 KIF1A MFN2
6 integument MP:0010771 9.86 AIFM1 DIAPH3 KIF1A NGF PNPLA6 POLG
7 muscle MP:0005369 9.5 AIFM1 GAN MFN2 NGF PMP22 POLG
8 nervous system MP:0003631 9.47 AIFM1 GAN GDAP1 GJB1 KIF1A MFN2

Drugs & Therapeutics for Neuropathy

Drugs for Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 975)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 148553-50-8 5486971
2
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 60142-96-3 3446
3
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56-12-2 119
4
Stavudine Approved, Investigational Phase 4,Phase 3 3056-17-5 18283
5
AT-101 Approved, Investigational Phase 4,Phase 3 90141-22-3, 652-67-5 12597
6
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 10102-43-9 145068
7
Isosorbide Dinitrate Approved, Investigational Phase 4,Phase 3 87-33-2 6883
8
Dorzolamide Approved Phase 4,Not Applicable 120279-96-1 5284549 3154
9
Timolol Approved Phase 4,Phase 3,Phase 1,Not Applicable 26839-75-8 33624 5478
10
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
11
Histamine Approved, Investigational Phase 4,Phase 2 51-45-6, 75614-87-8 774
12
Colistin Approved Phase 4 1264-72-8, 1066-17-7 5311054
13
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 57-27-2 5288826
14
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Not Applicable 103-90-2 1983
15
Ibuprofen Approved Phase 4,Phase 2,Phase 3,Not Applicable 15687-27-1 3672
16
Saxagliptin Approved Phase 4,Not Applicable 361442-04-8 11243969
17
Levofloxacin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 100986-85-4 149096
18
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
19
Clindamycin Approved, Vet_approved Phase 4,Not Applicable 18323-44-9 29029
20
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 26787-78-0 33613
21
Linezolid Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 165800-03-3 441401
22
Ofloxacin Approved Phase 4,Phase 2,Phase 3,Not Applicable 82419-36-1 4583
23
Piperacillin Approved Phase 4,Phase 3 66258-76-2 43672
24
Metronidazole Approved Phase 4,Phase 3,Phase 2 443-48-1 4173
25
Tazobactam Approved Phase 4,Phase 3 89786-04-9 123630
26
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2,Not Applicable 13422-51-0 11953898 44475014
27
Methylcobalamin Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 13422-55-4
28
leucovorin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 58-05-9 6006 143
29
Nabilone Approved, Investigational Phase 4,Phase 3 51022-71-0 5284592
30
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
31
Nortriptyline Approved Phase 4,Phase 2,Not Applicable 72-69-5 4543
32
Carbamazepine Approved, Investigational Phase 4,Not Applicable 298-46-4 2554
33 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
35
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 83-43-2 6741
36
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
37
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 302-25-0
38
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2921-57-5
39
Amitriptyline Approved Phase 4,Phase 3,Phase 2,Not Applicable 50-48-6 2160
40
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
41
Carboplatin Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 41575-94-4 10339178 38904 498142
42
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 216974-75-3
43
Travoprost Approved Phase 4,Phase 3 157283-68-6 5282226
44
Latanoprost Approved, Investigational Phase 4 130209-82-4 5311221 5282380
45
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Not Applicable 15307-86-5 3033
46
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
47
Bortezomib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 179324-69-7 387447 93860
48
Angiotensin II Approved, Investigational Phase 4,Phase 2,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
49
Fluorouracil Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 51-21-8 3385
50
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 61825-94-3 43805 6857599 5310940 9887054

Interventional clinical trials:

(show top 50) (show all 2636)
# Name Status NCT ID Phase Drugs
1 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy Unknown status NCT00123136 Phase 4
2 Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy Unknown status NCT01770964 Phase 4 Pregabalin;placebo
3 Omega-3 Fatty Acids and Chemotherapy-induced Neuropathy and Inflammation in Breast Cancer Unknown status NCT01049295 Phase 4
4 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
5 IVIg for Demyelination in Diabetes Mellitus Unknown status NCT02372149 Phase 4 10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
6 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
7 Evaluation of Viral Efficacy and Safety of a Reduced Dose of Stavudine (d4T): THE PHOENIX STUDY Unknown status NCT00235222 Phase 4 stavudine
8 Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Unknown status NCT00446810 Phase 4 Benfotiamine;Placebo
9 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
10 Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences. Unknown status NCT02033057 Phase 4
11 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4 Timolol & Dorzolamide
12 Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4 pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
13 Colistin Pharmacokinetics in Continuous Renal Replacement Therapy Unknown status NCT02081560 Phase 4 Colistin
14 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
15 Ultrasound-guided Caudal or Interlaminar Corticosteroid Epidural Injection for Sciatica Unknown status NCT02897336 Phase 4
16 IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia Unknown status NCT02504996 Phase 4 Paracetamol;morphine;Placebo
17 Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department Unknown status NCT02777320 Phase 4 paracetamol;Ibuprofen
18 Maggot Debridement Therapy Versus Conventional Dressing Therapy to Treat Diabetic Foot Ulcers Unknown status NCT02816749 Phase 4
19 Dipeptidyl Peptidase 4 Inhibition Facilitate Healing of Diabetic Ulcers Unknown status NCT02742233 Phase 4 saxagliptin;placebo
20 A Comparative Efficacy Study of DermaPure™ to Treat Diabetic Foot Ulcers Unknown status NCT02081352 Phase 4
21 Efficacy and Safety of Garamycin® Sponge (Gentamicin-Collagen Sponge) in Diabetic Patients With a Moderate or Severe Foot Ulcer Infection Unknown status NCT01951768 Phase 4 Garamycin Sponge (Gentamicin-Collagen sponge);Systemic Antibiotic
22 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
23 Safety and Efficacy of Mecobalamin Injection in Peripheral Neuropathies Patients (Study JGAZSY091109) Completed NCT01192113 Phase 4 Mecobalamin IV Injection;Mecobalamin IM injection;Mecobalamin IV or IM injection
24 The Effect of α-lipoic Acid Treatment in Patient With Cardiac Autonomic Neuropathy Completed NCT02056366 Phase 4 α-lipoic acid
25 Frequency Modulated Neural Stimulation (FREMS) in Symptomatic Diabetic Neuropathy Completed NCT01628627 Phase 4
26 A Randomized Double-Blind Study Testing the Effects of Pregabalin on Diabetic Neuropathy Completed NCT00573261 Phase 4 Pregabalin;Placebo
27 Effect of Pulsing Electrical Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study Completed NCT00614341 Phase 4
28 Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN) Completed NCT00726713 Phase 4
29 Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
30 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
31 A Study on the Efficacy and Safety of Gabapentin in the Treatment of Patients With Painful Diabetic Neuropathy Completed NCT00644748 Phase 4 gabapentin
32 A Study to Compare Safety and Efficacy of Tramadol Hydrochloride/Acetaminophen With Gabapentin in Participants With Diabetic Neuropathy Completed NCT00634543 Phase 4 Tramadol hydrochloride/ Acetaminophen;Gabapentin
33 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
34 Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Diabetic Peripheral Neuropathy Completed NCT00380913 Phase 4 Cesamet™ (nabilone)
35 Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy Completed NCT00159679 Phase 4 Pregabalin
36 A Study To Evaluate Pregabalin In Patients With Painful Diabetic Peripheral Neuropathy (DPN) Completed NCT00156078 Phase 4 pregabalin
37 Anodyne Therapy in Diabetic Sensory Neuropathy Completed NCT00120341 Phase 4
38 A Study of the Efficacy and Safety of Pregabalin for the Treatment of Diabetic Peripheral Neuropathy or Postherpetic Neuralgia Completed NCT00629681 Phase 4 Pregabalin
39 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
40 Evaluation of Rocker sOles in Diabetis Completed NCT02891928 Phase 4
41 Safety of Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy Completed NCT00159731 Phase 4 Pregabalin
42 A Study of the Effectiveness And Safety Of Lidoderm® As Add-On Treatment in Patients With Postherpetic Neuralgia, Diabetic Neuropathy, or Low Back Pain Completed NCT00904020 Phase 4 Lidoderm
43 Alpha Lipoic Acid for Treatment of Diabetic Neuropathy Completed NCT02439879 Phase 4 Alpha lipoic acid
44 A Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy (CIPN) Completed NCT01675531 Phase 4 Targin
45 Lidoderm® (Lidocaine Patch 5%) in Diabetic and Idiopathic Neuropathy Completed NCT00903851 Phase 4 Lidoderm
46 Clinical Study for Assessment of the Efficacy of Gabapentin (Carbatin and Neurontin) in Patients With Neuropathy Pain Completed NCT02074267 Phase 4 Carbatin;Neurontin
47 Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations Completed NCT02260388 Phase 4 Nortriptyline;Duloxetine;Pregabalin;Mexiletine
48 Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Chemotherapy-Induced Neuropathy Completed NCT00380965 Phase 4 Cesamet™ (nabilone)
49 Efficacy and Tolerability of Carbamazepine CR in Diabetic Neuropathy Pain Completed NCT01089855 Phase 4 Carbamazepine
50 Maintenance of Effect of Duloxetine in Patients With Diabetic Peripheral Neuropathic Pain (DPNP) Completed NCT00322621 Phase 4 Duloxetine

Search NIH Clinical Center for Neuropathy

Genetic Tests for Neuropathy

Anatomical Context for Neuropathy

MalaCards organs/tissues related to Neuropathy:

41
Testes, Skin, Heart, Bone, Brain, Eye, Kidney

The Foundational Model of Anatomy Ontology organs/tissues related to Neuropathy:

19
Nerves Or Nerve Cells

Publications for Neuropathy

Articles related to Neuropathy:

(show top 50) (show all 12171)
# Title Authors Year
1
Findings from aetiological investigation of Auditory Neuropathy Spectrum Disorder in children referred to cochlear implant programs. ( 30554714 )
2019
2
Cochlear implantation in children with auditory neuropathy: Lessons from Brown-Vialetto-Van Laere syndrome. ( 30332915 )
2019
3
Differences in skin blood flow oscillations between the plantar and dorsal foot in people with diabetes mellitus and peripheral neuropathy. ( 30414870 )
2019
4
Vasculitis and peripheral neuropathy. ( 30461543 )
2019
5
Leber's hereditary optic neuropathy: Shifting our attention to the macula. ( 30505979 )
2019
6
The role of skin biopsy in differentiating small-fiber neuropathy from ganglionopathy. ( 30520237 )
2019
7
Expression of pathogenic SCN9A mutations in the zebrafish: A model to study small-fiber neuropathy. ( 30316835 )
2019
8
Response to Crevenna and Ashbury, Vallance and Bolam, and Crevenna and Keilani regarding the effects of exercise on chemotherapy-induced peripheral neuropathy. ( 30374766 )
2019
9
Letter to the editor-comments on Kleckner et al. (2018) "Effects of exercise during chemotherapy-induced peripheral neuropathy: a multicenter, randomized controlled trial". ( 30032400 )
2019
10
Chemotherapy-induced peripheral neuropathy-more high-quality research is needed. ( 30046880 )
2019
11
Cure of human diabetic neuropathy by HPLC validated bark extract of Onosma echioides L. root. ( 29629826 )
2018
12
Hyperhomocysteinemia in bilateral anterior ischemic optic neuropathy after conventional coronary artery bypass graft: a case report. ( 29338755 )
2018
13
Different nerve ultrasound patterns in charcot-marie-tooth types and hereditary neuropathy with liability to pressure palsies. ( 28802056 )
2018
14
Pseudohemangioma in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 29784095 )
2018
15
Diabetic neuropathy and painful diabetic neuropathy: Cinderella complications in South East Asia. ( 29371725 )
2018
16
Clinical and genetic features of Charcot-Marie-Tooth disease 2F and hereditary motor neuropathy 2B in Japan. ( 29381233 )
2018
17
Diffusion-Weighted Imaging Changes in a Child With Posterior Ischemic Optic Neuropathy. ( 29859720 )
2018
18
Causes of peroneal neuropathy associated with orthopaedic leg lengthening in different canine models. ( 29802558 )
2018
19
Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. ( 29953490 )
2018
20
Spinobulbar muscular atrophy combined with atypical hereditary neuropathy with liability to pressure palsy. ( 29137918 )
2018
21
Genetic Testing for Wolfram Syndrome Mutations in a Sample of 71 Patients with Hereditary Optic Neuropathy and Negative Genetic Test Results for <i>OPA1/OPA3/LHON</i>. ( 29563951 )
2018
22
Could Buerger's disease cause nonarteritic anterior ischemic optic neuropathy?: a rare case report. ( 29623524 )
2018
23
Sciatic neuropathy and rhabdomyolysis after carbon monoxide intoxication: A case report. ( 29879074 )
2018
24
Safety of rAAV2/2-ND4 Gene Therapy for Leber Hereditary Optic Neuropathy. ( 29426586 )
2018
25
Analysis of Visual Field Defects Obtained with Semiautomated Kinetic Perimetry in Patients with Leber Hereditary Optic Neuropathy. ( 29750122 )
2018
26
Long-term Peripheral Neuropathy in Breast Cancer Patients Treated With Adjuvant Chemotherapy: NRG Oncology/NSABP B-30. ( 28954297 )
2018
27
Topiramate-induced Neuropathy Mimicking Carpal Tunnel Syndrome: A Case Report. ( 29430500 )
2018
28
Single fiber F-waves compared with conventional surface F-waves, and their utility in detecting early diabetic neuropathy. ( 29975798 )
2018
29
Longterm Reversal of Severe Visual Loss by Mitochondrial Gene Transfer in a Mouse Model of Leber Hereditary Optic Neuropathy. ( 29615737 )
2018
30
Insights into the Contribution of Voltage-Gated Sodium Channel 1.7 to Paclitaxel-Induced Neuropathy. ( 29973416 )
2018
31
The first case of hourglass-like constriction neuropathy of a digital nerve. ( 29449158 )
2018
32
Altered TDP-43-dependent splicing in HSPB8-related distal hereditary motor neuropathy and myofibrillar myopathy. ( 29029362 )
2018
33
Late-onset Leber hereditary optic neuropathy presenting after intraocular surgery. ( 29784175 )
2018
34
Chemotherapy-Associated Peripheral Neuropathy in Patients With Early-Stage Breast Cancer: A Systematic Review. ( 28954296 )
2018
35
Evaluation of Dizziness Handicap in Adolescents and Adults with Auditory Neuropathy Spectrum Disorder. ( 29371893 )
2018
36
Neuroprotective effect of duloxetine in a mouse model of diabetic neuropathy: Role of glia suppressing mechanisms. ( 29763613 )
2018
37
The CAPOS mutation in ATP1A3 alters Na/K-ATPase function and results in auditory neuropathy which has implications for management. ( 29305691 )
2018
38
Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients. ( 29896405 )
2018
39
Wernicke-Korsakoff syndrome complicated by subacute beriberi neuropathy in an alcoholic patient. ( 29128624 )
2018
40
A patient with peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and severe hypoganglionosis associated with a novel SOX10 mutation. ( 29681101 )
2018
41
Comparison of peripheral nerve blockade characteristics between non-diabetic patients and patients suffering from diabetic neuropathy: a prospective cohort study. ( 29858510 )
2018
42
Incidence and disease burden of chemotherapy-induced peripheral neuropathy in a population-based cohort. ( 29439162 )
2018
43
Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic neuropathy. ( 29273519 )
2018
44
Cardiovascular Autonomic Neuropathy and Glucose Variability in Patients With Type 1 Diabetes: Is There an Association? ( 29725320 )
2018
45
Ulnar neuropathy at wrist: entrapment at a very &amp;quot;congested&amp;quot; site. ( 29779137 )
2018
46
Cerebral Biochemical Effect of Pregabalin in Patients with Painful Diabetic Neuropathy: A Randomized Controlled Trial. ( 29951977 )
2018
47
Optimal Measurement Level and Ulnar Nerve Cross-Sectional Area Cutoff Threshold for Identifying Ulnar Neuropathy at the Elbow by MRI and Ultrasonography. ( 29622409 )
2018
48
Feasibility Trial of Treatment of Ulnar Neuropathy at the Elbow Using a Specifically Designed Splint. ( 29912777 )
2018
49
Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation. ( 29981335 )
2018
50
Feasibility and effectiveness of electrochemical dermal conductance measurement for the screening of diabetic neuropathy in primary care. DECODING Study (Dermal Electrochemical Conductance in Diabetic Neuropathy). Rationale and design. ( 29768354 )
2018

Variations for Neuropathy

Copy number variations for Neuropathy from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 107544 17 15900000 22100000 Microdeletion Neuropathy
2 107574 17 16000000 22200000 Copy number Neuropathy
3 216423 6 92100000 98700000 Microdeletion EPHA7 Neuropathy

Expression for Neuropathy

Search GEO for disease gene expression data for Neuropathy.

Pathways for Neuropathy

Pathways related to Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 GJB1 MPZ PMP22

GO Terms for Neuropathy

Cellular components related to Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine C-palmitoyltransferase complex GO:0017059 8.62 SPTLC1 SPTLC2

Biological processes related to Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peripheral nervous system development GO:0007422 9.4 NGF PMP22
2 ceramide biosynthetic process GO:0046513 9.37 SPTLC1 SPTLC2
3 mitochondrial fusion GO:0008053 9.32 GDAP1 MFN2
4 sphingosine biosynthetic process GO:0046512 9.26 SPTLC1 SPTLC2
5 sphingomyelin biosynthetic process GO:0006686 9.16 SPTLC1 SPTLC2
6 positive regulation of lipophagy GO:1904504 8.96 SPTLC1 SPTLC2
7 sphinganine biosynthetic process GO:0046511 8.62 SPTLC1 SPTLC2

Molecular functions related to Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine C-palmitoyltransferase activity GO:0004758 8.62 SPTLC1 SPTLC2

Sources for Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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