Aliases & Classifications for Neuropathy

MalaCards integrated aliases for Neuropathy:

Name: Neuropathy 12 15 40 17 72
Peripheral Neuropathy 12 72
Peripheral Neuropathies 15

Classifications:



External Ids:

Disease Ontology 12 DOID:870
NCIt 50 C4731
SNOMED-CT 68 42658009
ICD10 33 G62.9
UMLS 72 C0031117 C0442874

Summaries for Neuropathy

Disease Ontology : 12 A nervous system disease that is located in nerves or nerve cells.

MalaCards based summary : Neuropathy, also known as peripheral neuropathy, is related to neuropathy, hereditary, with liability to pressure palsies and neuropathy, hereditary sensory, type ie, and has symptoms including seizures, tremor and back pain. An important gene associated with Neuropathy is DLX6-AS1 (DLX6 Antisense RNA 1), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Pravastatin and Fexofenadine have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and skin, and related phenotypes are behavior/neurological and cellular

Related Diseases for Neuropathy

Diseases in the Neuropathy family:

Autoimmune Neuropathy Hereditary Neuropathies

Diseases related to Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2735)
# Related Disease Score Top Affiliating Genes
1 neuropathy, hereditary, with liability to pressure palsies 35.0 PMP22 MPZ MFN2 GJB1 GDAP1
2 neuropathy, hereditary sensory, type ie 34.9 SPTLC2 SPTLC1
3 hypertrophic neuropathy of dejerine-sottas 34.9 PMP22 MPZ GJB1 GDAP1
4 neuropathy, hereditary sensory and autonomic, type ic 34.8 SPTLC2 SPTLC1
5 hereditary sensory neuropathy 34.8 WNK1 SPTLC2 SPTLC1 NGF KIF1A
6 hereditary motor and sensory neuropathy, type iic 34.7 MPZ MFN2 GJB1 GDAP1
7 hereditary sensory and autonomic neuropathy type 1 34.6 SPTLC2 SPTLC1
8 autonomic neuropathy 34.6 WNK1 SPTLC2 SPTLC1 NGF KIF1A
9 charcot-marie-tooth disease, x-linked dominant, 1 34.5 PMP22 MPZ GJB1
10 charcot-marie-tooth disease, demyelinating, type 1b 34.4 PMP22 MPZ GJB1
11 charcot-marie-tooth hereditary neuropathy 34.4 PMP22 MPZ
12 charcot-marie-tooth disease, demyelinating, type 1c 34.3 PMP22 MPZ GJB1
13 charcot-marie-tooth disease, type 4d 34.3 MFN2 GJB1 GDAP1
14 charcot-marie-tooth disease, axonal, type 2b 34.3 SPTLC1 PMP22 MPZ GJB1
15 charcot-marie-tooth disease, demyelinating, type 1d 34.3 PMP22 MPZ GJB1
16 charcot-marie-tooth disease, demyelinating, type 1f 34.3 PMP22 MPZ GJB1
17 charcot-marie-tooth disease, axonal, type 2d 34.2 PMP22 MPZ GJB1
18 motor peripheral neuropathy 34.2 SLC12A6 PMP22 MPZ MFN2 GJB1
19 charcot-marie-tooth disease, demyelinating, type 1a 34.2 PMP22 MPZ MFN2 GJB1 GDAP1
20 charcot-marie-tooth disease, axonal, type 2k 34.1 MFN2 KIF1A GDAP1
21 charcot-marie-tooth disease and deafness 34.1 PMP22 MPZ MFN2 GJB1 GDAP1
22 axonal neuropathy 34.0 POLG PMP22 MFN2 GDAP1 GAN
23 sensory peripheral neuropathy 34.0 SPTLC1 SLC12A6 PMP22 NGF MPZ MFN2
24 charcot-marie-tooth disease, axonal, type 2f 33.9 MPZ GJB1
25 roussy-levy hereditary areflexic dystasia 33.9 PMP22 MPZ
26 charcot-marie-tooth disease, axonal, type 2e 33.8 SLC12A6 PMP22 MPZ MFN2 GJB1 GDAP1
27 charcot-marie-tooth disease 33.4 SPTLC1 POLG PMP22 MPZ MFN2 GJB1
28 charcot-marie-tooth disease type 2a2 33.2 MFN2 GAN
29 polyneuropathy 33.1 POLG PNPLA6 PMP22 MPZ GDAP1
30 foot drop 33.0 PMP22 MPZ
31 peripheral nervous system disease 32.8 SPTLC1 SLC12A6 POLG PNPLA6 PMP22 NGF
32 myoclonic epilepsy associated with ragged-red fibers 32.7 POLG MT-ND4 GDAP1
33 cranial nerve disease 32.6 POLG MT-ND4 MFN2
34 spinocerebellar degeneration 32.3 POLG PNPLA6
35 tooth disease 32.0 PMP22 MPZ MFN2 GJB1 GDAP1
36 amyotrophic neuralgia 31.5 PMP22 GJB1
37 chronic inflammatory demyelinating polyradiculoneuropathy 31.1 PMP22 MPZ
38 neurogenic arthropathy 30.8 SPTLC1 NGF
39 neuropathy, hereditary sensory and autonomic, type iia 12.7
40 neuropathy, congenital hypomyelinating, 1, autosomal recessive 12.6
41 neuropathy, hereditary sensory and autonomic, type v 12.6
42 diabetic neuropathy 12.6
43 neuropathy, hereditary motor and sensory, type via, with optic atrophy 12.6
44 neuromyotonia and axonal neuropathy, autosomal recessive 12.6
45 nonarteritic anterior ischemic optic neuropathy 12.6
46 neuropathy, hereditary sensory and autonomic, type vii 12.5
47 agenesis of the corpus callosum with peripheral neuropathy 12.5
48 neuropathy, hereditary motor and sensory, russe type 12.5
49 neuropathy, hereditary sensory and autonomic, type vi 12.5
50 neuropathy, hereditary motor and sensory, okinawa type 12.5

Graphical network of the top 20 diseases related to Neuropathy:



Diseases related to Neuropathy

Symptoms & Phenotypes for Neuropathy

UMLS symptoms related to Neuropathy:


seizures, tremor, back pain, pain, headache, syncope, hemiparesis, chronic pain, sciatica, vertigo/dizziness, sleeplessness, neuralgia, neurologic symptoms, atypical facial pain

MGI Mouse Phenotypes related to Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 AIFM1 GAN GDAP1 GJB1 KIF1A MFN2
2 cellular MP:0005384 10.22 AIFM1 DIAPH3 GAN GDAP1 GJB1 GP1BA
3 growth/size/body region MP:0005378 10.18 AIFM1 DIAPH3 GAN GJB1 KIF1A MFN2
4 homeostasis/metabolism MP:0005376 10.17 AIFM1 DIAPH3 GDAP1 GJB1 GP1BA MFN2
5 mortality/aging MP:0010768 10 AIFM1 DIAPH3 GAN GJB1 KIF1A MFN2
6 integument MP:0010771 9.91 AIFM1 DIAPH3 KIF1A NGF PNPLA6 POLG
7 muscle MP:0005369 9.56 AIFM1 GAN MFN2 NGF PMP22 POLG
8 nervous system MP:0003631 9.5 AIFM1 GAN GDAP1 GJB1 KIF1A MFN2

Drugs & Therapeutics for Neuropathy

Drugs for Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 855)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pravastatin Approved Phase 4 81093-37-0 54687
2
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
3
Allopurinol Approved Phase 4 315-30-0 2094
4
Timolol Approved Phase 4 26839-75-8 33624 5478
5
Dorzolamide Approved Phase 4 120279-96-1 3154 5284549
6
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
7
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
8
Dinoprostone Approved Phase 4 363-24-6 5280360
9
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
10
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
11
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
12
Mexiletine Approved, Investigational Phase 4 31828-71-4 4178
13
Zidovudine Approved Phase 4 30516-87-1 35370
14
Rifampicin Approved Phase 4 13292-46-1 5381226 5458213
15
Darunavir Approved Phase 4 206361-99-1, 635728-49-3 213039
16
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
17
Lopinavir Approved Phase 4 192725-17-0 92727
18
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
19
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
20
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
21
Nevirapine Approved Phase 4 129618-40-2 4463
22
Liraglutide Approved Phase 4 204656-20-2 44147092
23
Levodopa Approved Phase 4 59-92-7 6047
24
Glucagon Approved Phase 4 16941-32-5
25
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
26
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
27
Nortriptyline Approved Phase 4 72-69-5 4543
28
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
29
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
30
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
31
Testosterone enanthate Approved Phase 4 315-37-7 9416
32
Methyltestosterone Approved Phase 4 58-18-4 6010
33
Testosterone Approved, Experimental, Investigational Phase 4 481-30-1, 58-22-0 6013 10204
34
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
35
Travoprost Approved Phase 4 157283-68-6 5282226
36
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
37
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
38
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
39
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
40
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
41
Methimazole Approved Phase 4 60-56-0 1349907
42
Bezafibrate Approved, Investigational Phase 4 41859-67-0 39042
43
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
44
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
45
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
46
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
47
Aztreonam Approved Phase 4 78110-38-0 5742832 5362041
48
Methadone Approved, Illicit Phase 4 76-99-3 4095
49
Ofloxacin Approved Phase 4 82419-36-1 4583
50
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096

Interventional clinical trials:

(show top 50) (show all 2092)
# Name Status NCT ID Phase Drugs
1 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy. Multi-Center, Randomized Placebo Controlled Trial Unknown status NCT00123136 Phase 4
2 Treatment With Gamunex 10% Intravenous Immunoglobulin (IVIg) for Patients With Demyelination and Diabetes Mellitus: A Blinded, Placebo-Controlled Crossover Pilot Study Unknown status NCT02372149 Phase 4 10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
3 Evaluation of Viral Efficacy and Safety of a Reduced Dose of Stavudine (d4T): THE PHOENIX STUDY Unknown status NCT00235222 Phase 4 stavudine
4 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
5 A Multicenter, Double-blind, Randomized, Placebo and Active-controlled Study of Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4 pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
6 Randomized Controlled Study to Evaluate the Efficacy of Pravastatin on Survival and Recurrence of Advanced Gastroesophageal Cancer Unknown status NCT01038154 Phase 4 Pravastatin
7 Inspiratory Muscle Training in Patients With Autonomic Neuropathic: a Randomized Trial Unknown status NCT00752440 Phase 4
8 Evaluation of the Impact of Subject and Staff Training on the Pregabalin vs. Placebo Difference in Subjects With Painful Diabetic Neuropathy (PDN) Unknown status NCT01770964 Phase 4 Pregabalin;placebo
9 The Effects of Omega-3 Fatty Acids on Chemotherapy-induced Neuropathy and Inflammation in Patients With Breast Cancer Unknown status NCT01049295 Phase 4
10 Botox on Vulvar Vestibulitis Unknown status NCT00119886 Phase 4 Botulinum toxin
11 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
12 Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences. Unknown status NCT02033057 Phase 4
13 The Role of Qutenza (Topical Capsaicin 8%) in Treating Neuropathic Pain From Critical Ischaemia in Patients With End-stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
14 Effect of Allopurinol on Mono and Co-administration With Statins on Platelets Reactivity on Diabetic Patiets Treated With Aspirin and Insulin Unknown status NCT03195153 Phase 4 Atorvastatin 80mg;ALLOPURINOL 300 MG;Atorvastatin 80mg AND allopurinol 300 mg
15 A Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Intra-articular Catheter (IAC) Following Primary Total Knee Arthroplasty Unknown status NCT02497911 Phase 4 Ropivicaine;Bupivicaine
16 Effects of a Chronical Treatment With Benfotiamine in People With Type 2 Diabetes Mellitus on Pre- and Postprandial Endothelial Function, as Well as on the Function of the Autonomic Nervous System Unknown status NCT00446810 Phase 4 Benfotiamine;Placebo
17 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus. Unknown status NCT02011620 Phase 4
18 Effects of Pregabalin on Mechanical Hyperalgesia - EPOM Unknown status NCT00310583 Phase 4 Pregabalin
19 A Double-Blinded Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Local Infiltration of Analgesia (LIA) Following Primary Total Knee Arthroplasty Unknown status NCT02603900 Phase 4 ropivacaine;bupivacaine
20 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
21 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4 Timolol & Dorzolamide
22 Absorption and Utilization of a Mixed Meal in Type 1 Diabetes: Creation of a Biological and In Silico Biobank for the Optimization of Artificial Pancreas Systems. A Pilot Study. Unknown status NCT01800734 Phase 4
23 A Prospective Single Blind Randomised Controlled Study to Compare the Outcomes of Patients With Diabetes and Clinically Non-infected Neuro-ischaemic and Neuropathic Foot Ulcers Treated With and Without Oral Antibiotics. Unknown status NCT01418456 Phase 4 antibiotics
24 Multicentre Randomised Controled Trial Comparing the Effect of a New Self-gripping Lightweight Polyester Mesh and a Normal Sutured Lightweight Polyester Mesh on the Incidence of Chronic Inguinodynia in Lichtenstein Hernioplasty. Unknown status NCT01830452 Phase 4
25 An Open-label, Randomized, Multi-center Clinical Trial to Evaluate the Safety and Efficacy in Peripheral Neuropathies Patients Treated With Mecobalamin Injection Completed NCT01192113 Phase 4 Mecobalamin IV Injection;Mecobalamin IM injection;Mecobalamin IV or IM injection
26 Efficacy of Administration of Angiotensin Converting Enzyme Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
27 A Prospective, Open Label, Multi-Center, Study Of Pregabalin In The Treatment Of Neuropathic Pain Associated With Diabetic Peripheral Neuropathy, Postherpetic Neuralgia, HIV-Related Peripheral Neuropathic Pain And Chemotherapy Induced Peripheral Neuropathic Pain Completed NCT00407511 Phase 4 Pregabalin
28 A Multicenter Trial Evaluating the Efficacy of Cesamet™ for the Symptomatic Treatment of Pain in Patients With Diabetic Peripheral Neuropathy Completed NCT00380913 Phase 4 Cesamet™ (nabilone)
29 A 24 Week, Double-blind, Placebo-controlled, Multisite Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN) Completed NCT00726713 Phase 4
30 Efficacy and Safety of Pregabalin in an Open-label, Non-comparative, Flexible-dose Trial With Diabetic Peripheral Neuropathy or Postherpetic Neuralgia Completed NCT00629681 Phase 4 Pregabalin
31 A Randomized, Single-dose, Parallel-group Study to Evaluate the Pharmacokinetic Profiles of Two Formulation of Pregabalin in Healthy Volunteers Under Fasting Conditions Completed NCT03712475 Phase 4 Pregabalin
32 A Phase IV Clinical Trial. Effect of Pulsing Electromagnetic Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study Completed NCT00614341 Phase 4
33 A Randomized, Double Blind, Placebo Controlled Prospective Study to Evaluate the Effectiveness of Monochromatic Infrared Photo Energy to Improve Diabetic Sensory Neuropathy Completed NCT00120341 Phase 4
34 A Multicenter Trial Evaluating the Safety and Efficacy of Cesamet™ for the Symptomatic Treatment of Chemotherapy-Induced Neuropathic Pain in Patients With Cancer Completed NCT00380965 Phase 4 Cesamet™ (nabilone)
35 A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy Who Need Opioid Combination Treatment With Existing Pregabalin Treatment Completed NCT01675531 Phase 4 Targin
36 Multicenter, Randomized, Open-label, Parallel Group, Phase IV Study to Compare the Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in the Management of Diabetic Peripheral Neuropathic Pain Completed NCT01364298 Phase 4 Gabapentin/B-complex;Pregabalin
37 L-Arginine and Endothelial Dysfunction in Type 2 Diabetic Patients Completed NCT00902616 Phase 4
38 Evaluation of a Structured Algorithm for Intrathecal Bolus Doses of Ziconotide (Prialt®)- The Swedish Ziconotide Bolus Study Completed NCT01373983 Phase 4 Ziconotide
39 Safety and Efficacy of Nab-paclitaxel (Abraxane) in Combination With Carboplatin as First Line Treatment in Elderly Subjects With Advance Non-Small Cell Lung Cancer (NSCLC): A Phase IV, Randomized, Open-Label, Multicenter Study (Abound.70+) Completed NCT02151149 Phase 4 nab-paclitaxel;Carboplatin
40 Long Term, Double Blind, Randomized, Placebo Controlled Multi-center Study of FRE.M.S.- Frequency Modulated Neural Stimulation Lorenz Therapy™ in Symptomatic Diabetic Neuropathy Completed NCT01628627 Phase 4
41 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
42 An Open-Label Trial of Duloxetine for the Treatment of Irritable Bowel Syndrome Without Comorbid Major Depressive Disorder Completed NCT00401258 Phase 4 duloxetine
43 Randomized Double-blind Study Comparing the Efficacy of Duloxetine With Placebo in Patients With Chronic Low Back Pain With a Radicular Component Completed NCT01166048 Phase 4 Duloxetine;Duloxetine
44 Pilot Phase IV, Multicenter, Randomized, Open-label and Controlled Study to Assess the Evolution of Peripheral Body Fat Distribution After Switching From Zidovudine Containing Backbone to Truvada in HIV-1-infected Patients on HAART (RECOMB Study). Completed NCT00324649 Phase 4 Truvada;Zidovudine/lamivudine
45 Evaluation of Safety and Efficacy of Raltegravir/Darunavir Combination in Antiretroviral-Naive Patients Completed NCT00677300 Phase 4 Raltegravir;Darunavir;Ritonavir;Tenofovir/Emtricitabine
46 Exploratory, Cross-sectional Study to Compare the Virologic Efficacy in Cerebrospinal Fluid (CSF) and Neurocognitive State in Patients Infected by HIV-1 Long-term Treatment (> 3 Years) With Lopinavir / Ritonavir Monotherapy Completed NCT01116817 Phase 4
47 Comparison of the Steady State Pharmacokinetics of Nevirapine, Stavudine Plus Lamivudine in HIV Positive Ugandan Patients Taking Triomune 40 With the Pharmacokinetics of the Originator Products. Completed NCT00455585 Phase 4 nevirapine, stavudine, lamivudine
48 Randomised and Prospective Clinical Study to Evaluate the Efficacy and Safety of Lopinavir/Ritonavir Monotherapy Versus Darunavir/Ritonavir Monotherapies as Simplification Switching Strategies of PI/NNRTI-Triple Therapy Based-Regimens Completed NCT00994344 Phase 4 Darunavir/ritonavir;Lopinavir/ritonavir
49 The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty: A Double-Blinded Randomized Controlled Trial Completed NCT00620828 Phase 4 Ropivicaine 0.5%
50 A Prospective Randomized Trial Comparing the Response of HIV Kaposi's Sarcoma (KS) to HAART Versus the Combination of HAART and Chemotherapy (CXT) Completed NCT00380770 Phase 4 Generic HAART Triomune : d4T, 3TC, NVP;Generic HAART Triomune : d4T, 3TC, NVP and chemotherapy ABV

Search NIH Clinical Center for Neuropathy

Genetic Tests for Neuropathy

Anatomical Context for Neuropathy

MalaCards organs/tissues related to Neuropathy:

41
Breast, Testes, Skin, Lung, Heart, Brain, Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Neuropathy:

19
Nerves

Publications for Neuropathy

Articles related to Neuropathy:

(show top 50) (show all 39200)
# Title Authors PMID Year
1
Mean centering-triple divisor and ratio derivative-zero crossing for simultaneous determination of some diabetes drugs in their quaternary mixture with severely overlapping spectra. 38
31228859 2019
2
Diabetic neuropathy research: from mouse models to targets for treatment. 38
31290436 2019
3
Therapeutic benefits of maintaining mitochondrial integrity and calcium homeostasis by forced expression of Hsp27 in chemotherapy-induced peripheral neuropathy. 38
31176721 2019
4
Looking for an optimal pedal layout to improve the driving performance of patients with diabetic peripheral neuropathy. 38
31280809 2019
5
A comparative study on clinical features of anterior ischemic optic neuropathy and idiopathic optic neuritis. 38
30784250 2019
6
ER responses play a key role in Swiss-Cheese/Neuropathy Target Esterase-associated neurodegeneration. 38
31233884 2019
7
New pharmacological effect of fulvestrant to prevent oxaliplatin-induced neurodegeneration and mechanical allodynia in rats. 38
30515800 2019
8
Spinocerebellar ataxia type 2-neuronopathy or neuropathy? 38
31228263 2019
9
Polymorphisms in the promotor region of the CRBN gene as a predictive factor for peripheral neuropathy in the course of thalidomide-based chemotherapy in multiple myeloma patients. 38
31115923 2019
10
Optical Coherence Tomography Angiography of a Pale Optic Disc in Demyelinating Optic Neuritis and Ischemic Optic Neuropathy. 38
30893268 2019
11
Ischemic Optic Neuropathy Secondary to Intravascular Lymphoma. 38
30531633 2019
12
Cure of human diabetic neuropathy by HPLC validated bark extract of Onosma echioides L. root. 38
29629826 2019
13
Randomized Controlled Phase 2a Study of RPh201 in Previous Nonarteritic Anterior Ischemic Optic Neuropathy. 38
31430268 2019
14
Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B. 38
30721447 2019
15
Compound heterozygous mutations of SH3TC2 in Charcot-Marie-Tooth disease type 4C patients. 38
31227790 2019
16
Imaging of Peripheral Nerves of the Upper Extremity. 38
31351536 2019
17
A shared comparison of diabetes mellitus and neurodegenerative disorders. 38
30565720 2019
18
Biallelic variants in AGTPBP1, involved in tubulin deglutamylation, are associated with cerebellar degeneration and motor neuropathy. 38
30976113 2019
19
Spinocerebellar ataxia with axonal neuropathy type 1 revisited. 38
31182267 2019
20
Zebrafish is a central model to dissect the peripheral neuropathy. 38
31183681 2019
21
Hourglass-like constriction neuropathy of the suprascapular nerve detected by high-resolution magnetic resonance neurography: report of three patients. 38
30747238 2019
22
Suprascapular neuropathy: A review of 87 cases. 38
31294855 2019
23
Chronic inflammatory demyelinating polyneuropathy: update on diagnosis, immunopathogenesis and treatment. 38
30992333 2019
24
Neuropathy associated with immunoglobulin M monoclonal gammopathy: A combined sonographic and nerve conduction study. 38
31269243 2019
25
Patient-reported and clinician-reported chemotherapy-induced peripheral neuropathy in patients with early breast cancer: Current clinical practice. 38
31090930 2019
26
Characterizing patient-clinician chemotherapy-induced peripheral neuropathy assessment and management communication approaches. 38
31003878 2019
27
Microarray analyses of lncRNAs and mRNAs expression profiling associated with diabetic peripheral neuropathy in rats. 38
31025414 2019
28
Hypoglycaemic episodes and risk of diabetic peripheral neuropathy in patients with type 2 diabetes. 38
29128288 2019
29
Neuroleukemiosis: Diagnosis and management. 38
31387077 2019
30
Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats. 38
30974202 2019
31
Serum and Urinary Selenium Status in Patients with the Pre-diabetes and Diabetes in Northeast China. 38
30552607 2019
32
Soluble urokinase plasminogen activator receptor in type 1 diabetic children, relation to vascular complications. 38
31301955 2019
33
New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism. 38
31346658 2019
34
The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc- and Calmodulin-Regulated Cysteine SUMO Protease. 38
31088288 2019
35
Radiation Optic Neuropathy After Whole-Brain Radiation Therapy. 38
30801441 2019
36
Aspects of vincristine-induced neuropathy in hematologic malignancies: a systematic review. 38
31214762 2019
37
Suprascapular nerve decompression for treatment of neuropathy in a bucking bull. 38
31429650 2019
38
Latent autoimmune diabetes of adulthood (LADA) is associated with small fibre neuropathy. 38
30575096 2019
39
Motor conduction block and conduction velocity in Lewis-Sumner syndrome and multifocal motor neuropathy. 38
31272830 2019
40
Somatosensory predictors of response to pregabalin in painful chemotherapy-induced peripheral neuropathy: a randomized, placebo-controlled, crossover study. 38
31335651 2019
41
4-Phenylbutyric acid protects against vasculitic peripheral neuropathy induced by ischaemia-reperfusion through attenuating endoplasmic reticulum stress. 38
31119443 2019
42
Genome-wide DNA methylation profiling of human diabetic peripheral neuropathy in subjects with type 2 diabetes mellitus. 38
31132961 2019
43
Poly (ADP-Ribose) Polymerase Inhibition for Chemotherapy-Induced Peripheral Neuropathy: A Meta-Analysis of Placebo-Controlled Trials. 38
30839241 2019
44
Resveratrol alleviates nuclear factor-κB-mediated neuroinflammation in vasculitic peripheral neuropathy induced by ischaemia-reperfusion via suppressing endoplasmic reticulum stress. 38
31090224 2019
45
Efficacy of topical Citrullus colocynthis (bitter apple) extract oil in chemotherapy-induced peripheral neuropathy: A pilot double-blind randomized placebo-controlled clinical trial. 38
31373112 2019
46
A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies. 38
31127053 2019
47
Taurine protects against myelin damage of sciatic nerve in diabetic peripheral neuropathy rats by controlling apoptosis of schwann cells via NGF/Akt/GSK3β pathway. 38
31415759 2019
48
A single-arm phase II trial of weekly nanoparticle albumin-bound paclitaxel (nab-paclitaxel) monotherapy after standard of chemotherapy for previously treated advanced non-small cell lung cancer. 38
30993397 2019
49
Mutations in PIGB Cause an Inherited GPI Biosynthesis Defect with an Axonal Neuropathy and Metabolic Abnormality in Severe Cases. 38
31256876 2019
50
Varicella Zoster Virus Encephalitis Mimicking Nivolumab-Induced Autoimmune Neuropathy in a Patient with Lung Cancer. 38
31345336 2019

Variations for Neuropathy

Copy number variations for Neuropathy from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 107544 17 15900000 22100000 Microdeletion Neuropathy
2 107574 17 16000000 22200000 Copy number Neuropathy
3 216423 6 92100000 98700000 Microdeletion EPHA7 Neuropathy

Expression for Neuropathy

Search GEO for disease gene expression data for Neuropathy.

Pathways for Neuropathy

Pathways related to Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 PMP22 MPZ GJB1

GO Terms for Neuropathy

Cellular components related to Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine C-palmitoyltransferase complex GO:0017059 8.62 SPTLC2 SPTLC1

Biological processes related to Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peripheral nervous system development GO:0007422 9.4 PMP22 NGF
2 ceramide biosynthetic process GO:0046513 9.37 SPTLC2 SPTLC1
3 mitochondrial fusion GO:0008053 9.32 MFN2 GDAP1
4 sphingosine biosynthetic process GO:0046512 9.26 SPTLC2 SPTLC1
5 sphingomyelin biosynthetic process GO:0006686 9.16 SPTLC2 SPTLC1
6 positive regulation of lipophagy GO:1904504 8.96 SPTLC2 SPTLC1
7 sphinganine biosynthetic process GO:0046511 8.62 SPTLC2 SPTLC1

Molecular functions related to Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine C-palmitoyltransferase activity GO:0004758 8.62 SPTLC2 SPTLC1

Sources for Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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