MCID: NRP027
MIFTS: 21

Neuropathy, Painful

Categories: Neuronal diseases

Aliases & Classifications for Neuropathy, Painful

MalaCards integrated aliases for Neuropathy, Painful:

Name: Neuropathy, Painful 58 56

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive


HPO:

33
neuropathy, painful:
Onset and clinical course infantile onset
Inheritance autosomal recessive inheritance


Classifications:



Summaries for Neuropathy, Painful

MalaCards based summary : Neuropathy, Painful is related to neuropathy and diabetic neuropathy. An important gene associated with Neuropathy, Painful is TNFRSF1B (TNF Receptor Superfamily Member 1B). The drugs Norepinephrine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, and related phenotypes are fever and skeletal muscle atrophy

Description from OMIM: 256870

Related Diseases for Neuropathy, Painful

Diseases related to Neuropathy, Painful via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuropathy 10.5
2 diabetic neuropathy 10.3
3 peripheral nervous system disease 10.3
4 sensory peripheral neuropathy 9.9
5 erythermalgia, primary 9.8
6 sciatic neuropathy 9.8
7 reflex sympathetic dystrophy 9.6
8 anxiety 9.6
9 algoneurodystrophy 9.6

Graphical network of the top 20 diseases related to Neuropathy, Painful:



Diseases related to Neuropathy, Painful

Symptoms & Phenotypes for Neuropathy, Painful

Human phenotypes related to Neuropathy, Painful:

33
# Description HPO Frequency HPO Source Accession
1 fever 33 HP:0001945
2 skeletal muscle atrophy 33 HP:0003202
3 peripheral neuropathy 33 HP:0009830
4 lower limb muscle weakness 33 HP:0007340

Symptoms via clinical synopsis from OMIM:

58
Muscle:
muscle atrophy

Neuro:
sensory loss
leg weakness
progressive weakness
painful hands and feet

Misc:
infantile onset
aggravated by heat, hot weather or fever

Lab:
tomaculous (sausage shaped) swellings of myelin sheaths on nerve biopsy

Clinical features from OMIM:

256870

Drugs & Therapeutics for Neuropathy, Painful

Drugs for Neuropathy, Painful (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4,Phase 3,Phase 2 51-41-2 439260
2
Dopamine Approved Phase 4,Phase 3,Phase 2 62-31-7, 51-61-6 681
3
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
4
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 148553-50-8 5486971
5
Amitriptyline Approved Phase 4 50-48-6 2160
6
Cetirizine Approved Phase 4 83881-51-0 2678
7
Histamine Approved, Investigational Phase 4 51-45-6 774
8
Donepezil Approved Phase 4 120014-06-4 3152
9
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 7440-70-2 271
10 Dopamine Agents Phase 4,Phase 3,Phase 2
11 Duloxetine Hydrochloride Phase 4,Phase 3,Phase 2
12 Antidepressive Agents Phase 4,Phase 3,Phase 2
13 Antimanic Agents Phase 4
14 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
15 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
16 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Excitatory Amino Acid Antagonists Phase 4
18 Hormones Phase 4,Phase 3,Phase 2,Phase 1
19 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1
20 calcium channel blockers Phase 4,Phase 3,Phase 2,Phase 1
21 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
22 Anti-Anxiety Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
24 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
25 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4,Phase 3,Phase 2
26 Anticonvulsants Phase 4,Phase 3,Phase 2,Phase 1
27 Excitatory Amino Acids Phase 4
28 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Phase 1
29 Amitriptyline, perphenazine drug combination Phase 4
30 Anti-Allergic Agents Phase 4
31
Histamine Phosphate Phase 4 51-74-1 65513
32 Histamine H1 Antagonists Phase 4
33 Histamine H1 Antagonists, Non-Sedating Phase 4
34 Histamine Antagonists Phase 4
35 Cholinesterase Inhibitors Phase 4
36 Nootropic Agents Phase 4
37 Cholinergic Agents Phase 4
38
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 50-67-9 5202
39
Oxycodone Approved, Illicit, Investigational Phase 3 76-42-6 5284603
40
Tapentadol Approved Phase 3 175591-23-8 9838022
41 Desvenlafaxine Succinate Phase 3 386750-22-7
42 Analgesics, Opioid Phase 3
43 Narcotics Phase 3
44 Adrenergic Agents Phase 3
45
Adenosine Approved, Investigational Phase 2 58-61-7 60961
46
Lidocaine Approved, Vet_approved Phase 1, Phase 2,Phase 2 137-58-6 3676
47
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
48
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 6857599 5310940 9887054 43805
49
leucovorin Approved Phase 1, Phase 2 58-05-9 6006 143
50
Lacosamide Approved Phase 2 175481-36-4, 860352-01-8 219078

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Frequency Modulated Neural Stimulation (FREMS) in Symptomatic Diabetic Neuropathy Completed NCT01628627 Phase 4
2 An Open-Label Comparison of Duloxetine to Other Alternatives for the Management of Diabetic Peripheral Neuropathic Pain Completed NCT00385671 Phase 4 duloxetine hydrochloride;pregabalin;gabapentin
3 Tolerability of Switching to Duloxetine for the Management of Diabetic Nerve Pain Completed NCT00266643 Phase 4 duloxetine hydrochloride
4 Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy Completed NCT00159679 Phase 4 Pregabalin
5 A Study To Evaluate Pregabalin In Patients With Painful Diabetic Peripheral Neuropathy (DPN) Completed NCT00156078 Phase 4 pregabalin
6 Influence of OCT2 Inhibitor Cetirizine and Type 2 Diabetes on Gabapentin Kinetics Disposition in Patients With Neuropathic Pain Enrolling by invitation NCT03047278 Phase 4 Gabapentin 300 mg;Cetirizine Hydrochloride 10 mg
7 Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy Terminated NCT00619983 Phase 4 donepezil;duloxetine;donepezil 2.5 mg and duloxetine 30mg;placebo;gabapentin
8 Study To Evaluate Efficacy, Safety And Tolerability Of Lyrica In Patients With Painful Diabetic Peripheral Neuropathy Completed NCT01332149 Phase 3 Pregabalin;Placebo matched with pregabalin
9 A Study in Participants With Diabetic Peripheral Neuropathic Pain in China Completed NCT01179672 Phase 3 Duloxetine;Placebo
10 A Study in Painful Diabetic Neuropathy Completed NCT01089556 Phase 3 Duloxetine;Pregabalin;Placebo
11 Study Of Pregabalin (Lyrica) In Patients With Painful Diabetic Peripheral Neuropathy Completed NCT01057693 Phase 3 pregabalin (Lyrica);Placebo
12 Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy Completed NCT00553475 Phase 3 placebo;pregabalin;pregabalin
13 A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy Completed NCT00553280 Phase 3 pregabalin
14 To Evaluate the Safety and Efficacy of Pregabalin in Patients With Painful Diabetic Peripheral Neuropathy. Completed NCT00150423 Phase 3 Pregabalin
15 Safety and Efficacy of Pregabalin in Patients With Diabetic Peripheral Neuropathy. Completed NCT00141401 Phase 3 Pregabalin
16 A Study for the Treatment of Painful Diabetic Neuropathy Completed NCT00058968 Phase 3 Duloxetine hydrochloride;placebo
17 Phase 3 Gene Therapy for Painful Diabetic Neuropathy Active, not recruiting NCT02427464 Phase 3
18 Study Evaluating the Long-Term Safety of Desvenlafaxine Succinate Sustained-Release (DVS SR) in Subjects With Pain Associated With Diabetic Peripheral Neuropathy Terminated NCT01050218 Phase 3 Desvenlafaxine Succinate Sustained-Release (DVS SR)
19 A Long-term Safety Study With Tapentadol ER and Oxycodone CR in Patients With Moderate to Severe Pain Due to Chronic, Painful Diabetic Peripheral Neuropathy (DPN) Terminated NCT01063868 Phase 3 Tapentadol extended release (ER);Oxycodone controlled release (CR)
20 A Clinical Trial To Evaluate PF-05089771 On Its Own And As An Add-On Therapy To Pregabalin (Lyrica) For The Treatment Of Pain Due To Diabetic Peripheral Neuropathy (DPN) Completed NCT02215252 Phase 2 PF-05089771 150 mg;Matched placebo for PF-05089771 150 mg and pregabalin 300 mg;Pregabalin 300 mg;PF-05089771 150 mg + Pregabalin 300 mg
21 Study to Evaluate MK-6096 in the Treatment of Painful Diabetic Neuropathy (PDN) in Adults (MK-6096-021) Completed NCT01564459 Phase 2 MK-6096;Placebo
22 A Study for Treatment of Pain in Patients With Diabetic Neuropathy. Completed NCT00785577 Phase 2 Placebo;Pregabalin;LY545694 21 mg;LY545694 49 mg;LY545694 105 mg
23 Safety and Efficacy of AGN 203818 in Patients With Painful Diabetic Peripheral Neuropathy Completed NCT00381719 Phase 2 AGN 203818;AGN 203818;AGN 203818;placebo capsule
24 Safety, Tolerability and Preliminary Efficacy of AZD5213 in Combination With Pregabalin in Subjects With PDN and Good Pain Reporting Ability Completed NCT01928381 Phase 2 AZD5213 + pregabalin;Placebo;pregabalin capsules
25 Efficacy and Tolerability of Novel A2A Agonist in Treatment of Diabetic Neuropathic Pain Completed NCT00452777 Phase 2 BVT.115959;Placebo
26 Study for Safety and Effectiveness of RWJ-333369 (Carsibamate) for the Treatment of Diabetic Peripheral Neuropathy (DPN). Completed NCT00501202 Phase 2 placebo;RWJ-333369 (carisbamate)
27 An Efficacy and Safety Study of Carisbamate in the Treatment of Nerve Pain in Diabetics Completed NCT00870454 Phase 2 Pregabalin 300 mg/d;Carisbamate 800 mg/d;Carisbamate 1,200 mg/d;Placebo
28 Safety and Efficacy Study in Subjects With Diabetic Neuropathic Pain Completed NCT00507936 Phase 2 ABT-894;ABT-894;ABT-894;placebo;Duloxetine
29 Lidocaine for Oxaliplatin-induced Neuropathy Recruiting NCT03254394 Phase 1, Phase 2 Lidocaine Hydrochloride;Placebo;FOLFOX regimen
30 The Effect of Lacosamide in Peripheral Neuropathic Pain Not yet recruiting NCT03777956 Phase 2 Lacosamide;Placebo
31 Study Evaluating EAA-090 in Adult Outpatients With Neuropathic Pain Associated With Diabetic Neuropathy Terminated NCT00073034 Phase 2 EAA-090
32 Safety and Efficacy Study of BC-DN-01 in Painful Diabetic Peripheral Neuropathy Withdrawn NCT01793350 Phase 1, Phase 2 BC-DN-01 topically applied cream
33 A Trial of Lidocaine Patch for Lower Limb Amputation Pain Withdrawn NCT02696720 Phase 2 Lidocaine
34 Bioequivalence Study of Two Formulations of Pregabalin CR (Controlled-release) Table 150 mg Completed NCT02955472 Phase 1 GLA5PR GLARS-NF3 tablet 150mg;GLA5PR GLARS-NF1 tablet 150mg
35 Bioequivalence Study of Two Formulations of Pregabalin CR(Controlled-release) Table 300 mg Completed NCT02952937 Phase 1 GLA5PR GLARS-NF3 tablet 300mg;GLA5PR GLARS-NF1 tablet 300mg
36 Preliminary Assessment of the Efficacy of the VascuActive™ Device on Diabetic Peripheral Neuropathy Unknown status NCT01214590 Not Applicable
37 Thermal Biofeedback for the Treatment of Diabetic Neuropathy Completed NCT00858351 Not Applicable
38 Treatment of Painful Diabetic Neuropathy With Photon Stimulation Completed NCT00539175 Not Applicable
39 Graded Exposure in Patients With Painful Diabetic Neuropathy Recruiting NCT03066570 Not Applicable
40 Evaluation of an Effectiveness and Safety of the Electroacupuncture in the Management of Intractable Neuropathic Pain Recruiting NCT03315598 Not Applicable

Search NIH Clinical Center for Neuropathy, Painful

Genetic Tests for Neuropathy, Painful

Anatomical Context for Neuropathy, Painful

MalaCards organs/tissues related to Neuropathy, Painful:

42
Skeletal Muscle

Publications for Neuropathy, Painful

Variations for Neuropathy, Painful

Expression for Neuropathy, Painful

Search GEO for disease gene expression data for Neuropathy, Painful.

Pathways for Neuropathy, Painful

GO Terms for Neuropathy, Painful

Sources for Neuropathy, Painful

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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