MCID: NRP027
MIFTS: 21

Neuropathy, Painful

Categories: Neuronal diseases

Aliases & Classifications for Neuropathy, Painful

MalaCards integrated aliases for Neuropathy, Painful:

Name: Neuropathy, Painful 57 54

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal recessive


HPO:

31
neuropathy, painful:
Inheritance autosomal recessive inheritance
Onset and clinical course infantile onset


Classifications:



Summaries for Neuropathy, Painful

MalaCards based summary : Neuropathy, Painful is related to diabetic polyneuropathy and polyneuropathy. An important gene associated with Neuropathy, Painful is TNFRSF1B (TNF Receptor Superfamily Member 1B). The drugs Pregabalin and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, and related phenotypes are fever and skeletal muscle atrophy

More information from OMIM: 256870

Related Diseases for Neuropathy, Painful

Diseases related to Neuropathy, Painful via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 diabetic polyneuropathy 9.8
2 polyneuropathy 9.8
3 neuropathy 9.8
4 diabetes mellitus 9.8
5 diabetic neuropathy 9.8

Graphical network of the top 20 diseases related to Neuropathy, Painful:



Diseases related to Neuropathy, Painful

Symptoms & Phenotypes for Neuropathy, Painful

Human phenotypes related to Neuropathy, Painful:

31
# Description HPO Frequency HPO Source Accession
1 fever 31 HP:0001945
2 skeletal muscle atrophy 31 HP:0003202
3 peripheral neuropathy 31 HP:0009830
4 lower limb muscle weakness 31 HP:0007340

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Misc:
infantile onset
aggravated by heat, hot weather or fever

Muscle:
muscle atrophy

Neuro:
sensory loss
leg weakness
progressive weakness
painful hands and feet

Lab:
tomaculous (sausage shaped) swellings of myelin sheaths on nerve biopsy

Clinical features from OMIM®:

256870 (Updated 20-May-2021)

Drugs & Therapeutics for Neuropathy, Painful

Drugs for Neuropathy, Painful (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Amitriptyline Approved Phase 4 50-48-6 2160
4
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
5
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
6 Analgesics Phase 4
7 Psychotropic Drugs Phase 4
8 Hormones Phase 4
9 Anti-Anxiety Agents Phase 4
10 Anticonvulsants Phase 4
11 calcium channel blockers Phase 4
12 Calcium, Dietary Phase 4
13 Neurotransmitter Agents Phase 4
14 Dopamine Agents Phase 4
15 Duloxetine Hydrochloride Phase 4
16 Amitriptyline, perphenazine drug combination Phase 4
17 Excitatory Amino Acid Antagonists Phase 4
18 Sodium Channel Blockers Phase 4
19 Diuretics, Potassium Sparing Phase 4
20
Calcium Nutraceutical Phase 4 7440-70-2 271
21
Norepinephrine Approved Phase 3 51-41-2 439260
22
Tapentadol Approved Phase 3 175591-23-8 9838022
23
Oxycodone Approved, Illicit, Investigational Phase 3 76-42-6 5284603
24
Milnacipran Approved, Investigational Phase 3 92623-85-3 65833
25
Levomilnacipran Approved, Investigational Phase 3 96847-54-0
26 Antidepressive Agents Phase 3
27 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
28 Narcotics Phase 3
29 Analgesics, Opioid Phase 3
30 Adrenergic Agents Phase 3
31 Desvenlafaxine Succinate Phase 3 386750-22-7
32 Analgesics, Non-Narcotic Phase 3
33
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
34
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
35
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 5310940 9887054 6857599 43805
36
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
37
leucovorin Approved Phase 1, Phase 2 58-05-9 6006
38 Anti-Arrhythmia Agents Phase 1, Phase 2
39 Pharmaceutical Solutions Phase 1, Phase 2
40 Anesthetics, Local Phase 1, Phase 2
41 Anesthetics Phase 1, Phase 2
42 taxane

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Long Term, Double Blind, Randomized, Placebo Controlled Multi-center Study of FRE.M.S.- Frequency Modulated Neural Stimulation Lorenz Therapy™ in Symptomatic Diabetic Neuropathy Completed NCT01628627 Phase 4
2 A Comparison of Strategies for Switching Patients From Amitriptyline to Duloxetine for the Management of Diabetic Peripheral Neuropathic Pain Completed NCT00266643 Phase 4 duloxetine hydrochloride
3 A 13 Week, Double-Blind, Placebo-Controlled Phase 4 Trial of Pregabalin (CI-1008, 600 mg/Day) for Relief of Pain in Subjects With Painful Diabetic Peripheral Neuropathy Completed NCT00159679 Phase 4 Pregabalin
4 A 14-Week, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study To Evaluate The Safety And Efficacy Of Pregabalin (150mg-600mg/Day) Using A Flexible Optimal Dose Schedule In Patients With Painful Diabetic Peripheral Neuropathy (DPN). Completed NCT00156078 Phase 4 pregabalin
5 An Open-Label, Randomized Comparison of Duloxetine, Pregabalin, and the Combination of Duloxetine and Gabapentin Among Patients With Inadequate Response to Gabapentin for the Management of Diabetic Peripheral Neuropathic Pain Completed NCT00385671 Phase 4 duloxetine hydrochloride;pregabalin;gabapentin
6 Phase IV Open Non Comparative Trial to Evaluate Efficacy and Safety of Tegretol® in Diabetes Neuropathy Pain. Completed NCT01089855 Phase 4 Carbamazepine
7 Clinical Study for Assessment of the Efficacy of Gabapentin (Carbatin and Neurontin) in Patients With Neuropathy Pain Completed NCT02074267 Phase 4 Carbatin;Neurontin
8 Randomized, Double-Blind, Multicenter, Placebo-Controlled Study To Evaluate Efficacy And Safety Of Pregabalin (CI-1008) In The Treatment For Pain Associated With Diabetic Peripheral Neuropathy Completed NCT00553475 Phase 3 placebo;pregabalin;pregabalin
9 A PHASE 3B MULTICENTER, DOUBLE-BLIND, RANDOMIZED WITHDRAWAL EFFICACY AND SAFETY STUDY OF PREGABALIN IN THE TREATMENT OF PATIENTS WITH INADEQUATELY TREATED PAINFUL DIABETIC PERIPHERAL NEUROPATHY Completed NCT01057693 Phase 3 pregabalin (Lyrica);Placebo
10 Treatment of Patients With Diabetic Peripheral Neuropathic Pain in China: Duloxetine Versus Placebo Completed NCT01179672 Phase 3 Duloxetine;Placebo
11 An Open-Label Extension Safety And Efficacy Study Of Pregabalin (CI-1008) For Pain Associated With Diabetic Peripheral Neuropathy Completed NCT00553280 Phase 3 pregabalin
12 Use of Duloxetine or Pregabalin in Monotherapy Versus Combination Therapy of Both Drugs in Patients With Painful Diabetic Neuropathy "The COMBO - DN (COmbination vs Monotherapy of pregaBalin and dulOxetine in Diabetic Neuropathy) Study" Completed NCT01089556 Phase 3 Duloxetine;Pregabalin;Placebo
13 An 11-week Randomized, Double-blind, Multi Center, Placebo-controlled Study To Evaluate The Efficacy, Safety And Tolerability Of Pregabalin (300 Mg/Day) Using A Fixed Dosing Schedule In The Treatment Of Subjects S With Pain Associated With Diabetic Peripheral Neuropathy. Completed NCT01332149 Phase 3 Pregabalin;Placebo matched with pregabalin
14 An Open-Label, Extension Safety and Efficacy Study of Pregabalin in Patients With Painful Diabetic Peripheral Neuropathy. Completed NCT00141401 Phase 3 Pregabalin
15 Duloxetine Versus Placebo in the Treatment of Patients With Painful Diabetic Neuropathy Completed NCT00058968 Phase 3 Duloxetine hydrochloride;placebo
16 An Open-Label, Extension Safety and Efficacy Study of Pregabalin in Patients With Painful Diabetic Peripheral Neuropathy. Completed NCT00150423 Phase 3 Pregabalin
17 An Adaptive, Phase 3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Safety and Efficacy of Engensis in Participants With Painful Diabetic Peripheral Neuropathy Recruiting NCT04469270 Phase 3
18 A One-Year, Randomized, Open-Label, Parallel-Group, Multiple-Dose Long-Term Safety Study With Controlled Adjustment of Dose of Tapentadol Extended-Release (ER) and Oxycodone Controlled-Release (CR) in Subjects With Chronic, Painful Diabetic Peripheral Neuropathy (DPN) Terminated NCT01063868 Phase 3 Tapentadol extended release (ER);Oxycodone controlled release (CR)
19 A 9-Month Open-Label Extension Study of the Long-Term Safety of DVS SR in Outpatients With Pain Associated With Diabetic Peripheral Neuropathy Terminated NCT01050218 Phase 3 Desvenlafaxine Succinate Sustained-Release (DVS SR)
20 A Placebo Controlled, Randomized, Double Blind Trial of Milnacipran for the Treatment of Idiopathic Neuropathy Pain Terminated NCT01288937 Phase 3 Milnacipran;Placebo
21 A Phase 2 Study of the Effects of LY545694, an iGluR5 Antagonist, in the Treatment of Subjects With Painful Diabetic Neuropathy. Completed NCT00785577 Phase 2 Placebo;Pregabalin;LY545694 21 mg;LY545694 49 mg;LY545694 105 mg
22 A Randomized, Double-Blind, Placebo-Controlled Crossover Study to Evaluate the Preliminary Efficacy of AZD5213 in Combination With Pregabalin in Subjects With Painful Diabetic Neuropathy and Good Pain Reporting Ability Completed NCT01928381 Phase 2 AZD5213 + pregabalin;Placebo;pregabalin capsules
23 A Phase IIa, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial to Evaluate the Safety and Efficacy of MK-6096 in Patients With Painful Diabetic Neuropathy Completed NCT01564459 Phase 2 MK-6096;Placebo
24 A Randomized, Double-Blind, Placebo-Controlled, Crossover Study of RWJ 333369 for the Treatment of Neuropathic Pain in Diabetic Peripheral Neuropathy. Completed NCT00501202 Phase 2 placebo;RWJ-333369 (carisbamate)
25 A Randomized Double Blind Placebo And Active Controlled Parallel Group Phase 2 Study To Evaluate PF-05089771 As A Monotherapy And As An Add-on To Pregabalin For The Treatment Of Painful Diabetic Peripheral Neuropathy Completed NCT02215252 Phase 2 PF-05089771 150 mg;Matched placebo for PF-05089771 150 mg and pregabalin 300 mg;Pregabalin 300 mg;PF-05089771 150 mg + Pregabalin 300 mg
26 Safety and Efficacy of AGN 203818 in Patients With Painful Diabetic Peripheral Neuropathy Completed NCT00381719 Phase 2 AGN 203818;AGN 203818;AGN 203818;placebo capsule
27 Intravenous Lidocaine for Preventing Painful Oxaliplatin-induced Peripheral Neuropathy (OIPN) Active, not recruiting NCT03254394 Phase 1, Phase 2 Lidocaine Hydrochloride;Placebo;FOLFOX regimen
28 An Open-Label 52-Week Safety Study of Bicifadine SR in Adult Outpatients With Chronic Peripheral Neuropathic Pain Associated With Diabetic Peripheral Neuropathy Terminated NCT00597649 Phase 2 Bicifadine
29 A Combined Phase 1 + 2 Clinical Trial Evaluating the Safety and Efficacy of BC-DN-01 in the Treatment of Painful Diabetic Peripheral Neuropathy Withdrawn NCT01793350 Phase 1, Phase 2 BC-DN-01 topically applied cream
30 A Open-label, Randomized, Crossover Clinical Trial to Assess the PK of Pregabalin CR After Multiple Dosing as Compared to Pregabalin IR and the Food Effect of High Fat Diet After Single Dosing in Healthy Male Volunteers Completed NCT02783638 Phase 1 YHD1119;Lyrica
31 Preliminary Assessment of the Efficacy of the VascuActive™ Device on Diabetic Peripheral Neuropathy Unknown status NCT01214590
32 A Placebo-Controlled Trial of Thermal Biofeedback Assisted Relaxation for the Treatment of Diabetic Neuropathy: An Evaluation of Outcomes and Mechanisms Completed NCT00858351
33 Treatment of Painful Diabetic Neuropathy With Photon Stimulation Completed NCT00539175
34 EPT 101: New Geranium Oil Formulation for the Treatment of Neuropathy Pain Completed NCT00611949
35 A Double-Blind, Placebo-Controlled Randomized Evaluation of the Effect of the Erchonia FX-635 on Diabetic Peripheral Neuropathy Pain Completed NCT02461225
36 Hilotherapy vs Frozen Gloves for Preventing Taxane-related Peripheral Neuropathy, Pain and Nail Toxicity in Breast Cancer Completed NCT04659980
37 A Double-blind, Placebo-controlled Randomized Evaluation of the Effect of the Erchonia® FX-635™ on Diabetic Peripheral Neuropathy Pain Recruiting NCT04006392

Search NIH Clinical Center for Neuropathy, Painful

Genetic Tests for Neuropathy, Painful

Anatomical Context for Neuropathy, Painful

MalaCards organs/tissues related to Neuropathy, Painful:

40
Skeletal Muscle

Publications for Neuropathy, Painful

Articles related to Neuropathy, Painful:

(show all 21)
# Title Authors PMID Year
1
An obscure inherited neuropathy characterized by pain and weakness. 57
897927 1977
2
The increase of neuropathic symptoms in diabetic patients is related with osteopenia. 61
33216284 2020
3
Reduced vitamin D levels in painful diabetic peripheral neuropathy. 61
30102801 2019
4
Diabetic neuropathy and painful diabetic neuropathy: Cinderella complications in South East Asia. 61
29371725 2018
5
Sleep disorders and chronic craniofacial pain: Characteristics and management possibilities. 61
27321865 2017
6
Prevalence of Foot Ulcers, Foot at Risk and Associated Risk Factors Among Jordanian Diabetics. 61
26652612 2017
7
Patient reported outcome measures of pain intensity: Do they tell us what we need to know? 61
28850473 2016
8
Up-regulation of CX3CL1 via Nuclear Factor-κB-dependent Histone Acetylation Is Involved in Paclitaxel-induced Peripheral Neuropathy. 61
25494456 2015
9
Diabetic neuropathy. 61
24286949 2013
10
[Sjogren's syndrome-associated neuropathy]. 61
24200611 2013
11
Guidelines in the management of diabetic nerve pain: clinical utility of pregabalin. 61
23467255 2013
12
[II. neurological diseases related to diabetes mellitus: 1. Diabetic peripheral neuropathies (diabetic polyneuropathy, focal and multifocal diabetic neuropathy, painful diabetic neuropathy]. 61
22973687 2012
13
Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells. 61
22374260 2012
14
Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. 61
20876709 2010
15
National Institute of Neurological Disorders and Stroke (NINDS): advances in understanding and treating neuropathy, 24-25 October 2006; Bethesda, Maryland. 61
18346227 2008
16
Buprenorphine--a review of its role in neuropathic pain. 61
17957979 2007
17
Symptom profiles differ in patients with neuropathic versus non-neuropathic pain. 61
16949878 2007
18
[How I explore. . . vasculitis of the peripheral nervous system]. 61
16358669 2005
19
Relief of painful diabetic peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial. 61
15820913 2005
20
Pain-related differential expression of NGF, GDNF, IL-6, and their receptors in human vasculitic neuropathies. 54
14686749 2003
21
Health state preference assessment in diabetic peripheral neuropathy. 61
12456202 2002

Variations for Neuropathy, Painful

Expression for Neuropathy, Painful

Search GEO for disease gene expression data for Neuropathy, Painful.

Pathways for Neuropathy, Painful

GO Terms for Neuropathy, Painful

Sources for Neuropathy, Painful

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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