Aliases & Classifications for Neuropathy, Painful

MalaCards integrated aliases for Neuropathy, Painful:

Name: Neuropathy, Painful 57 55



autosomal recessive


neuropathy, painful:
Inheritance autosomal recessive inheritance
Onset and clinical course infantile onset


External Ids:

OMIM 57 256870
MedGen 42 C1850383

Summaries for Neuropathy, Painful

MalaCards based summary : Neuropathy, Painful is related to neuropathy and diabetic neuropathy. An important gene associated with Neuropathy, Painful is TNFRSF1B (TNF Receptor Superfamily Member 1B). The drugs Dopamine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, and related phenotypes are skeletal muscle atrophy and lower limb muscle weakness

Description from OMIM: 256870

Related Diseases for Neuropathy, Painful

Diseases related to Neuropathy, Painful via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuropathy 10.2
2 diabetic neuropathy 9.9
3 peripheral nervous system disease 9.8
4 sciatic neuropathy 9.7
5 sensory peripheral neuropathy 9.7
6 erythermalgia, primary 9.5
7 reflex sympathetic dystrophy 9.5
8 algoneurodystrophy 9.5

Graphical network of the top 20 diseases related to Neuropathy, Painful:

Diseases related to Neuropathy, Painful

Symptoms & Phenotypes for Neuropathy, Painful

Symptoms via clinical synopsis from OMIM:

progressive weakness
leg weakness
painful hands and feet
sensory loss

infantile onset
aggravated by heat, hot weather or fever

muscle atrophy

tomaculous (sausage shaped) swellings of myelin sheaths on nerve biopsy

Clinical features from OMIM:


Human phenotypes related to Neuropathy, Painful:

# Description HPO Frequency HPO Source Accession
1 skeletal muscle atrophy 32 HP:0003202
2 lower limb muscle weakness 32 HP:0007340
3 peripheral neuropathy 32 HP:0009830

Drugs & Therapeutics for Neuropathy, Painful

Drugs for Neuropathy, Painful (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
Norepinephrine Approved Phase 4,Phase 3,Phase 2 51-41-2 439260
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
Amitriptyline Approved Phase 4 50-48-6 2160
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 148553-50-8 5486971
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
Cetirizine Approved Phase 4 83881-51-0 2678
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
Donepezil Approved Phase 4 120014-06-4 3152
10 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
11 calcium channel blockers Phase 4,Phase 3,Phase 2,Phase 1
12 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
13 GABA Agents Phase 4
14 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4,Phase 3,Phase 2
15 Amitriptyline, perphenazine drug combination Phase 4
16 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
17 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
18 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Anti-Anxiety Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Dopamine Agents Phase 4,Phase 3,Phase 2
21 Duloxetine Hydrochloride Phase 4,Phase 3,Phase 2
22 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Excitatory Amino Acid Antagonists Phase 4
24 Excitatory Amino Acids Phase 4
25 Anticonvulsants Phase 4,Phase 3,Phase 2,Phase 1
26 Antidepressive Agents Phase 4,Phase 3,Phase 2
27 Antiparkinson Agents Phase 4
28 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1
29 Antimanic Agents Phase 4
30 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
Histamine Phosphate Phase 4 51-74-1 65513
32 Histamine Antagonists Phase 4
33 Histamine H1 Antagonists Phase 4
34 Histamine H1 Antagonists, Non-Sedating Phase 4
35 Anti-Allergic Agents Phase 4
36 Cholinergic Agents Phase 4
37 Cholinesterase Inhibitors Phase 4
38 Nootropic Agents Phase 4
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 50-67-9 5202
Oxycodone Approved, Illicit, Investigational Phase 3 76-42-6 5284603
41 Desvenlafaxine Succinate Phase 3 386750-22-7
42 Narcotics Phase 3
43 Analgesics, Opioid Phase 3
Adenosine Approved, Investigational Phase 2 58-61-7 60961
Lidocaine Approved, Vet_approved Phase 1, Phase 2,Phase 2 137-58-6 3676
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 5310940 9887054 43805 6857599
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
leucovorin Approved, Nutraceutical Phase 1, Phase 2 58-05-9 143 6006
49 Sodium Channel Blockers Phase 1, Phase 2,Phase 2
50 Anesthetics Phase 1, Phase 2,Phase 2

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Frequency Modulated Neural Stimulation (FREMS) in Symptomatic Diabetic Neuropathy Completed NCT01628627 Phase 4
2 An Open-Label Comparison of Duloxetine to Other Alternatives for the Management of Diabetic Peripheral Neuropathic Pain Completed NCT00385671 Phase 4 duloxetine hydrochloride;pregabalin;gabapentin
3 Tolerability of Switching to Duloxetine for the Management of Diabetic Nerve Pain Completed NCT00266643 Phase 4 duloxetine hydrochloride
4 Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy Completed NCT00159679 Phase 4 Pregabalin
5 A Study To Evaluate Pregabalin In Patients With Painful Diabetic Peripheral Neuropathy (DPN) Completed NCT00156078 Phase 4 pregabalin
6 Influence of OCT2 Inhibitor Cetirizine and Type 2 Diabetes on Gabapentin Kinetics Disposition in Patients With Neuropathic Pain Enrolling by invitation NCT03047278 Phase 4 Gabapentin 300 mg;Cetirizine Hydrochloride 10 mg
7 Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy Terminated NCT00619983 Phase 4 donepezil;duloxetine;donepezil 2.5 mg and duloxetine 30mg;placebo;gabapentin
8 Study To Evaluate Efficacy, Safety And Tolerability Of Lyrica In Patients With Painful Diabetic Peripheral Neuropathy Completed NCT01332149 Phase 3 Pregabalin;Placebo matched with pregabalin
9 A Study in Participants With Diabetic Peripheral Neuropathic Pain in China Completed NCT01179672 Phase 3 Duloxetine;Placebo
10 A Study in Painful Diabetic Neuropathy Completed NCT01089556 Phase 3 Duloxetine;Pregabalin;Placebo
11 Study Of Pregabalin (Lyrica) In Patients With Painful Diabetic Peripheral Neuropathy Completed NCT01057693 Phase 3 pregabalin (Lyrica);Placebo
12 Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy Completed NCT00553475 Phase 3 placebo;pregabalin;pregabalin
13 A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy Completed NCT00553280 Phase 3 pregabalin
14 To Evaluate the Safety and Efficacy of Pregabalin in Patients With Painful Diabetic Peripheral Neuropathy. Completed NCT00150423 Phase 3 Pregabalin
15 Safety and Efficacy of Pregabalin in Patients With Diabetic Peripheral Neuropathy. Completed NCT00141401 Phase 3 Pregabalin
16 A Study for the Treatment of Painful Diabetic Neuropathy Completed NCT00058968 Phase 3 Duloxetine hydrochloride;placebo
17 Phase 3 Gene Therapy for Painful Diabetic Neuropathy Recruiting NCT02427464 Phase 3
18 Study Evaluating the Long-Term Safety of Desvenlafaxine Succinate Sustained-Release (DVS SR) in Subjects With Pain Associated With Diabetic Peripheral Neuropathy Terminated NCT01050218 Phase 3 Desvenlafaxine Succinate Sustained-Release (DVS SR)
19 A Long-term Safety Study With Tapentadol ER and Oxycodone CR in Patients With Moderate to Severe Pain Due to Chronic, Painful Diabetic Peripheral Neuropathy (DPN) Terminated NCT01063868 Phase 3 Tapentadol extended release (ER);Oxycodone controlled release (CR)
20 A Clinical Trial To Evaluate PF-05089771 On Its Own And As An Add-On Therapy To Pregabalin (Lyrica) For The Treatment Of Pain Due To Diabetic Peripheral Neuropathy (DPN) Completed NCT02215252 Phase 2 PF-05089771 150 mg;Matched placebo for PF-05089771 150 mg and pregabalin 300 mg;Pregabalin 300 mg;PF-05089771 150 mg + Pregabalin 300 mg
21 Study to Evaluate MK-6096 in the Treatment of Painful Diabetic Neuropathy (PDN) in Adults (MK-6096-021) Completed NCT01564459 Phase 2 MK-6096;Placebo
22 A Study for Treatment of Pain in Patients With Diabetic Neuropathy. Completed NCT00785577 Phase 2 Placebo;Pregabalin;LY545694 21 mg;LY545694 49 mg;LY545694 105 mg
23 Safety and Efficacy of AGN 203818 in Patients With Painful Diabetic Peripheral Neuropathy Completed NCT00381719 Phase 2 AGN 203818;AGN 203818;AGN 203818;placebo capsule
24 Safety, Tolerability and Preliminary Efficacy of AZD5213 in Combination With Pregabalin in Subjects With PDN and Good Pain Reporting Ability Completed NCT01928381 Phase 2 AZD5213 + pregabalin;Placebo;pregabalin capsules
25 Efficacy and Tolerability of Novel A2A Agonist in Treatment of Diabetic Neuropathic Pain Completed NCT00452777 Phase 2 BVT.115959;Placebo
26 Study for Safety and Effectiveness of RWJ-333369 (Carsibamate) for the Treatment of Diabetic Peripheral Neuropathy (DPN). Completed NCT00501202 Phase 2 placebo;RWJ-333369 (carisbamate)
27 An Efficacy and Safety Study of Carisbamate in the Treatment of Nerve Pain in Diabetics Completed NCT00870454 Phase 2 Pregabalin 300 mg/d;Carisbamate 800 mg/d;Carisbamate 1,200 mg/d;Placebo
28 Safety and Efficacy Study in Subjects With Diabetic Neuropathic Pain Completed NCT00507936 Phase 2 ABT-894;ABT-894;ABT-894;placebo;Duloxetine
29 Lidocaine for Oxaliplatin-induced Neuropathy Recruiting NCT03254394 Phase 1, Phase 2 Lidocaine Hydrochloride;Placebo;FOLFOX regimen
30 Study Evaluating EAA-090 in Adult Outpatients With Neuropathic Pain Associated With Diabetic Neuropathy Terminated NCT00073034 Phase 2 EAA-090
31 Safety and Efficacy Study of BC-DN-01 in Painful Diabetic Peripheral Neuropathy Withdrawn NCT01793350 Phase 1, Phase 2 BC-DN-01 topically applied cream
32 A Trial of Lidocaine Patch for Lower Limb Amputation Pain Withdrawn NCT02696720 Phase 2 Lidocaine
33 Bioequivalence Study of Two Formulations of Pregabalin CR (Controlled-release) Table 150 mg Completed NCT02955472 Phase 1 GLA5PR GLARS-NF3 tablet 150mg;GLA5PR GLARS-NF1 tablet 150mg
34 Bioequivalence Study of Two Formulations of Pregabalin CR(Controlled-release) Table 300 mg Completed NCT02952937 Phase 1 GLA5PR GLARS-NF3 tablet 300mg;GLA5PR GLARS-NF1 tablet 300mg
35 Preliminary Assessment of the Efficacy of the VascuActive™ Device on Diabetic Peripheral Neuropathy Unknown status NCT01214590 Not Applicable
36 Thermal Biofeedback for the Treatment of Diabetic Neuropathy Completed NCT00858351 Not Applicable
37 Treatment of Painful Diabetic Neuropathy With Photon Stimulation Completed NCT00539175 Not Applicable
38 Graded Exposure in Patients With Painful Diabetic Neuropathy Recruiting NCT03066570 Not Applicable
39 Evaluation of an Effectiveness and Safety of the Electroacupuncture in the Management of Intractable Neuropathic Pain Recruiting NCT03315598 Not Applicable

Search NIH Clinical Center for Neuropathy, Painful

Genetic Tests for Neuropathy, Painful

Anatomical Context for Neuropathy, Painful

MalaCards organs/tissues related to Neuropathy, Painful:

Skeletal Muscle

Publications for Neuropathy, Painful

Articles related to Neuropathy, Painful:

# Title Authors Year
Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation. ( 29981335 )
A randomized controlled pilot study on the dietary intervention for chronic diabetic neuropathy pain. ( 27728151 )
Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-alpha-mediated mechanism. ( 23533304 )

Variations for Neuropathy, Painful

Expression for Neuropathy, Painful

Search GEO for disease gene expression data for Neuropathy, Painful.

Pathways for Neuropathy, Painful

GO Terms for Neuropathy, Painful

Sources for Neuropathy, Painful

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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