MCID: NRS005
MIFTS: 32

Neurosarcoidosis

Categories: Immune diseases

Aliases & Classifications for Neurosarcoidosis

MalaCards integrated aliases for Neurosarcoidosis:

Name: Neurosarcoidosis 12 53 15 70
Cerebral Sarcoidosis 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:13403
NCIt 50 C35441
SNOMED-CT 67 111936002
UMLS 70 C0393485 C0398676

Summaries for Neurosarcoidosis

NINDS : 53 Neurosarcoidosis is a manifestation of sarcoidosis in the nervous system.  Sarcoidosis is a chronic inflammatory disorder that typically occurs in adults between 20 and 40 years of age and primarily affects the lungs, but can also impact almost every other organ and system in the body.  Neurosarcoidosis is characterized by inflammation and abnormal cell deposits in any part of the nervous system – the brain, spinal cord, or peripheral nerves.  It most commonly occurs in the cranial and facial nerves, the hypothalamus (a specific area of the brain), and the pituitary gland.  It is estimated to develop in 5 to 15 percent of those individuals who have sarcoidosis.  Weakness of the facial muscles on one side of the face (Bell’s palsy) is a common symptom of neurosarcoidosis.  The optic and auditory nerves can also become involved, causing vision and hearing impairments.  It can cause headache, seizures, memory loss, hallucinations, irritability, agitation, and changes in mood and behavior.  Neurosarcoidosis can appear in an acute, explosive fashion or start as a slow chronic illness.  Because neurosarcoidosis manifests in many different ways, a diagnosis may be difficult and delayed.

MalaCards based summary : Neurosarcoidosis, also known as cerebral sarcoidosis, is related to neuritis and optic neuritis. An important gene associated with Neurosarcoidosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Yersinia infection and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include pituitary, spinal cord and hypothalamus.

Disease Ontology : 12 A sarcoidosis that is characterized by involvement of the nervous symptom with cranial nerve palsy, diffuse meningeal disease, acute polyneuropathy, myelitis, or hypothalamic pituitary axis malformation, develops from a type IV hypersensitivity reaction with noncaseating granulomas involving the nervous system.

Wikipedia : 73 Neurosarcoidosis (sometimes shortened to neurosarcoid) refers to a type of sarcoidosis, a condition of... more...

Related Diseases for Neurosarcoidosis

Diseases related to Neurosarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 649)
# Related Disease Score Top Affiliating Genes
1 neuritis 30.5 TNF MOG AQP4
2 optic neuritis 30.4 TNF MOG AQP4
3 myelitis 30.4 TNF MOG AQP4
4 sarcoidosis 1 30.3 TNF CRP CD8A CD4 ACE
5 transverse myelitis 30.2 TNF MOG AQP4
6 polyneuropathy 30.0 TNF CRP ACE
7 multiple cranial nerve palsy 30.0 CRP ACE
8 acute disseminated encephalomyelitis 30.0 PNMA2 MOG AQP4
9 granulomatous angiitis 30.0 CRP ACE
10 meningitis 30.0 TNF CRP AQP4
11 chronic meningitis 30.0 MIR642A CRP CD4
12 inappropriate adh syndrome 29.9 AQP4 ACE
13 internuclear ophthalmoplegia 29.9 MOG AQP4
14 tolosa-hunt syndrome 29.9 CRP ACE
15 cranial nerve palsy 29.7 CRP CD4 AQP4 ACE
16 encephalitis 29.7 TNF PNMA2 MOG AQP4
17 papilledema 29.6 CRP CD4 AQP4 ACE
18 skin sarcoidosis 29.6 TNF CD8A CD4 ACE
19 cerebral lymphoma 29.6 CD8A CD4
20 choroiditis 29.6 TNF CD4 ACE
21 mononeuropathy 29.6 TNF CRP CD4
22 retinal vasculitis 29.6 TNF CD4 ACE
23 bell's palsy 29.5 CD8A CD4
24 central nervous system tuberculosis 29.5 TNF MIR642A CD4
25 raynaud disease 29.5 CRP ACE
26 bacterial meningitis 29.4 TNF CRP AQP4
27 iridocyclitis 29.4 TNF CRP CD4 ACE
28 arachnoiditis 29.4 TNF CRP CD4 AQP4
29 autoimmune disease 29.3 TNF MOG CRP AQP4
30 multiple sclerosis 29.3 TNF MOG CD8A CD4 AQP4
31 sleep apnea 29.3 TNF CRP ACE
32 mononeuritis multiplex 29.3 TNF CRP CD4 ACE
33 facial paralysis 29.3 TNF CRP CD8A CD4 ACE
34 corneal disease 29.2 TNF CD8A CD4
35 stroke, ischemic 29.2 TNF CRP AQP4 ACE
36 glucose intolerance 29.2 TNF CRP ACE
37 meningoencephalitis 29.2 TNF CRP CD8A CD4
38 optic nerve disease 29.2 TNF MOG CRP CD4 AQP4
39 uveoparotid fever 29.1 TNF CD8A CD4 ACE
40 central nervous system vasculitis 29.1 TNF CRP CD8A CD4
41 end stage renal disease 29.1 TNF CRP ACE
42 lung disease 29.0 TNF CRP CD8A ACE
43 respiratory failure 28.9 TNF CRP CD8A CD4 ACE
44 optic papillitis 28.9 MOG CRP CD4 AQP4 ACE
45 urticaria 28.9 CRP CD4 ACE TNF
46 panuveitis 28.8 TNF CRP CD8A CD4 ACE
47 peripheral nervous system disease 28.7 TNF MOG CRP CD8A CD4 AQP4
48 demyelinating disease 28.7 TNF MOG CD8A CD4 AQP4
49 chickenpox 28.6 TNF CRP CD8A CD4
50 disease by infectious agent 28.6 TNF CRP CD8A CD4

Graphical network of the top 20 diseases related to Neurosarcoidosis:



Diseases related to Neurosarcoidosis

Symptoms & Phenotypes for Neurosarcoidosis

Drugs & Therapeutics for Neurosarcoidosis

Search Clinical Trials , NIH Clinical Center for Neurosarcoidosis

Genetic Tests for Neurosarcoidosis

Anatomical Context for Neurosarcoidosis

MalaCards organs/tissues related to Neurosarcoidosis:

40
Pituitary, Spinal Cord, Hypothalamus, Medulla Oblongata, Pineal, Eye, Brain

Publications for Neurosarcoidosis

Articles related to Neurosarcoidosis:

(show top 50) (show all 1102)
# Title Authors PMID Year
1
A rare case of spinal epidural sarcoidosis: case report and review of the literature. 61
31297669 2021
2
Infliximab for relapsing neurosarcoidosis recurring after kidney transplantation: a case report. 61
31486719 2021
3
Cochlear Implantation in Sporadic Vestibular Schwannoma and Other Retrocochlear Pathology: A Case Series. 61
33351558 2021
4
Neurosarcoidosis presenting as isolated VI nerve palsy. 61
33095367 2021
5
Tumour necrosis factor inhibitor monotherapy for CNS neurosarcoidosis. 61
33785576 2021
6
Diabetes insipidus secondary to sellar/parasellar lesions. 61
33769630 2021
7
Intracranial Tuberculoma Mimicking Neurosarcoidosis: A Clinical Challenge. 61
33804334 2021
8
Neurosarcoidosis with parenchymal nodules aligned in the temporal lobe. 61
33755183 2021
9
Neurosarcoidosis - a patient series. 61
33754685 2021
10
Neurosarcoidosis Masquerading as Giant Cell Arteritis With Incidental Meningioma. 61
32441899 2021
11
Overcoming the Elusiveness of Neurosarcoidosis: Learning from Five Complex Cases. 61
33805852 2021
12
A 46-Year-Old Presenting With Inferior Mononuclear Visual Field Defect as the Sole Manifestation of Neurosarcoidosis. 61
33728109 2021
13
Elevated Neurofilament Light Chain in Cerebrospinal Fluid and Plasma Reflect Inflammatory MRI Activity in Neurosarcoidosis. 61
33672795 2021
14
Tumefactive multiple sclerosis (TMS): A case series of this challenging variant of MS. 61
33373797 2021
15
Minocycline and Cephalexin in a Patient with Spastic Neuropathic Pain Secondary to Neurosarcoidosis. 61
33560414 2021
16
Acute central nervous system vasculitis as a manifestation of neurosarcoidosis: A case report and literature review. 61
33354273 2021
17
Letter to the Editor regarding "Endoscopic Management for Recurrent Hydrocephalus Associated with Neurosarcoidosis". 61
33607737 2021
18
Neurosarcoidosis Directly Involving the Cervical Vagus Nerve. 61
32659110 2021
19
Neuroimaging of Spinal Cord and Cauda Equina Disorders. 61
33522744 2021
20
Cortical Vein Thrombosis, Tortuous Venous Vasculature, and Microhemorrhages in Neurosarcoidosis. 61
33587111 2021
21
MRI signs of CNS demyelinating diseases. 61
33310421 2021
22
Effects of immunotherapies and clinical outcomes in neurosarcoidosis: a retrospective cohort study. 61
33515298 2021
23
Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural Lipomatosis. 61
33604089 2021
24
Teaching NeuroImages: Spinal Neurosarcoidosis: An Eccentric Manifestation. 61
32907959 2021
25
Unexpected diagnosis of metastatic breast carcinoma in an endomyocardial biopsy done for cardiac allograft rejection evaluation. 61
32814149 2021
26
Tuberculous perihepatic abscess and neurosarcoidosis: report of 2 uncommon manifestations of 2 common granulomatous diseases in 1 patient. 61
33429450 2021
27
Molecular Association of Medulloblastoma and Sarcoidosis: Case Report and Review of the Literature. 61
33010513 2021
28
Spontaneous dissolution of a cyst located within the septum pellucidum in a patient with sarcoidosis: a case report. 61
33489313 2021
29
A multi-center case series of sarcoid optic neuropathy. 61
33358503 2021
30
An unusual presentation of neurosarcoidosis: Concurrent optic perineuritis and optic neuritis. 61
33767965 2021
31
FLT-PET for the assessment of systemic sarcoidosis including cardiac and CNS involvement: a prospective study with comparison to FDG-PET. 61
33301054 2020
32
Heerfordt-Waldenström Syndrome. 61
33247650 2020
33
Endoscopic Management for Recurrent Hydrocephalus Associated with Neurosarcoidosis. 61
32890842 2020
34
A case of Mycobacterium bovis Bacillus Calmette-Guérin (BCG) strain meningitis and ventriculitis following BCG vaccination. 61
32976992 2020
35
Central Nervous System Lymphoma Masquerading as Neurosarcoidosis. 61
33191325 2020
36
Probable neurosarcoidosis presenting as acute on chronic otorrhoea: a difficult diagnosis. 61
33139371 2020
37
Frequency and etiology of acute transverse myelitis in Southern Finland. 61
33059215 2020
38
Incidental Finding of a Duplicated Vertebral Artery Followed by a Spinal Dural Arteriovenous Fistula on Spinal Angiography. 61
33304686 2020
39
Neurosarcoidosis presenting with isolated intracranial mass lesion and communicating hydrocephalus. 61
31882303 2020
40
Neurosarcoidosis in acute inpatient rehabilitation: a case study. 61
33139707 2020
41
Cerebrospinal fluid CD4+ /CD8+ ratio in diagnosing neurosarcoidosis. 61
32533774 2020
42
Hypothalamic-Pituitary Axis Dysfunction, Central Diabetes Insipidus, and Syndrome of Inappropriate Antidiuretic Hormone Secretion as the First Clinical Presentation of Neurosarcoidosis: Why Early Diagnosis and Treatment is Important? 61
33329977 2020
43
A Case of Neurosarcoidosis Mimicking Brain Tumor. 61
33213326 2020
44
Neurosarcoidosis: Analysis of a series of 20 patients. 61
32564930 2020
45
Neurosarcoidosis presenting with hypopituitarism. 61
33012710 2020
46
A Case of Central Diabetes Insipidus Secondary to Neurosarcoidosis. 61
33240714 2020
47
Neurosarcoidosis and Ocular Inflammation: A Case Series and Literature Review. 61
33136665 2020
48
Neurosarcoidosis As a Rare Differential Diagnosis for Single Or Multiple Lesions of the Nervous System. 61
30295542 2020
49
The effect of race on clinical presentation and outcomes in neurosarcoidosis. 61
32771711 2020
50
Neuro-Ophthalmic Manifestations of Sarcoidosis. 61
33110001 2020

Variations for Neurosarcoidosis

Expression for Neurosarcoidosis

Search GEO for disease gene expression data for Neurosarcoidosis.

Pathways for Neurosarcoidosis

GO Terms for Neurosarcoidosis

Cellular components related to Neurosarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 TNF MOG CD8A CD4 AQP4 ACE

Biological processes related to Neurosarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of lipid storage GO:0010888 8.62 TNF CRP

Sources for Neurosarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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