MCID: NRS005
MIFTS: 25

Neurosarcoidosis

Categories: Eye diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Neurosarcoidosis

MalaCards integrated aliases for Neurosarcoidosis:

Name: Neurosarcoidosis 54 73

Classifications:



External Ids:

UMLS 73 C0393485

Summaries for Neurosarcoidosis

NINDS : 54 Neurosarcoidosis is a manifestation of sarcoidosis in the nervous system.  Sarcoidosis is a chronic inflammatory disorder that typically occurs in adults between 20 and 40 years of age and primarily affects the lungs, but can also impact almost every other organ and system in the body.  Neurosarcoidosis is characterized by inflammation and abnormal cell deposits in any part of the nervous system – the brain, spinal cord, or peripheral nerves.  It most commonly occurs in the cranial and facial nerves, the hypothalamus (a specific area of the brain), and the pituitary gland.  It is estimated to develop in 5 to 15 percent of those individuals who have sarcoidosis.  Weakness of the facial muscles on one side of the face (Bell’s palsy) is a common symptom of neurosarcoidosis.  The optic and auditory nerves can also become involved, causing vision and hearing impairments.  It can cause headache, seizures, memory loss, hallucinations, irritability, agitation, and changes in mood and behavior.  Neurosarcoidosis can appear in an acute, explosive fashion or start as a slow chronic illness.  Because neurosarcoidosis manifests in many different ways, a diagnosis may be difficult and delayed.

MalaCards based summary : Neurosarcoidosis is related to hydrocephalus and diabetes insipidus. An important gene associated with Neurosarcoidosis is ACE (Angiotensin I Converting Enzyme). The drugs Hormones and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and spinal cord.

Wikipedia : 76 Neurosarcoidosis (sometimes shortened to neurosarcoid) refers to sarcoidosis, a condition of unknown... more...

Related Diseases for Neurosarcoidosis

Diseases related to Neurosarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 hydrocephalus 10.3
2 diabetes insipidus 10.2
3 neuropathy 10.2
4 meningitis 10.1
5 multiple sclerosis 10.1
6 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
7 headache 10.1
8 myelitis 10.0
9 transverse myelitis 10.0
10 amenorrhea 10.0
11 optic nerve disease 10.0
12 glioma 10.0
13 rheumatoid arthritis 9.9
14 anosmia 9.9
15 arthritis 9.9
16 common variable immunodeficiency 9.9
17 thrombosis 9.9
18 patulous eustachian tube 9.9
19 dementia 9.9
20 obstructive hydrocephalus 9.9
21 peripheral nervous system disease 9.9
22 hypopituitarism 9.9
23 encephalitis 9.9
24 degos 'en cocarde' erythrokeratoderma 9.9
25 idiopathic hypertrophic pachymeningitis 9.9
26 depression 9.9
27 tremor 9.9
28 encephalopathy 9.9
29 igg4-related pachymeningitis 9.9
30 amenorrhea-galactorrhea syndrome 9.7
31 amyotrophic lateral sclerosis 1 9.7
32 schizophrenia 9.7
33 thrombophilia due to thrombin defect 9.7
34 galactorrhea 9.7
35 intracranial hypertension, idiopathic 9.7
36 aspergillosis 9.7
37 hepatitis 9.7
38 pulmonary sarcoidosis 9.7
39 sinusitis 9.7
40 invasive aspergillosis 9.7
41 lymphoma 9.7
42 sensorineural hearing loss 9.7
43 asymptomatic neurosyphilis 9.7
44 chronic meningitis 9.7
45 meningoencephalitis 9.7
46 respiratory failure 9.7
47 schizophreniform disorder 9.7
48 aseptic meningitis 9.7
49 skin sarcoidosis 9.7
50 multiple cranial nerve palsy 9.7

Graphical network of the top 20 diseases related to Neurosarcoidosis:



Diseases related to Neurosarcoidosis

Symptoms & Phenotypes for Neurosarcoidosis

Drugs & Therapeutics for Neurosarcoidosis

Drugs for Neurosarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 4
2 Hormone Antagonists Phase 4
3 beta-endorphin Phase 4
4 Melanocyte-Stimulating Hormones Phase 4
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
6 Adrenocorticotropic Hormone Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ACTHAR Therapy for Central Nervous System Sarcoidosis Not yet recruiting NCT02920710 Phase 4 Repository Corticotropin Injection
2 Registry for Advanced Sarcodiosis Recruiting NCT03769987
3 Analysis of the Distribution of Regulatory B Cells in Blood of Multiple Sclerosis Patients Recruiting NCT02789670

Search NIH Clinical Center for Neurosarcoidosis

Genetic Tests for Neurosarcoidosis

Anatomical Context for Neurosarcoidosis

MalaCards organs/tissues related to Neurosarcoidosis:

41
Brain, Lung, Spinal Cord, Pituitary, Testes, Hypothalamus, Eye

Publications for Neurosarcoidosis

Articles related to Neurosarcoidosis:

(show top 50) (show all 520)
# Title Authors Year
1
Usefulness of 18F-FDG-PET/CT imaging in a patient with neurosarcoidosis. ( 29685313 )
2018
2
Neurosarcoidosis associated with intracerebral haemorrhage: a challenge in diagnosis and management. ( 29363557 )
2018
3
Carotid arteritis causing amaurosis fugax and ischaemic cerebrovascular events in neurosarcoidosis. ( 29653415 )
2018
4
An atypical case of neurosarcoidosis presenting with neovascular glaucoma. ( 29671151 )
2018
5
Cerebrovascular manifestations in neurosarcoidosis: how common are they and does perivascular enhancement matter? ( 29970245 )
2018
6
Not everything is as it seems: neurosarcoidosis presenting as leptomeningitis. ( 29636921 )
2018
7
Anosmia as the initial presentation of neurosarcoidosis. ( 30478068 )
2018
8
A case of fatal invasive aspergillosis in a patient with neurosarcoidosis treated with infliximab. ( 30430892 )
2018
9
Neurosarcoidosis Mimics High-Grade Glioma in Dynamic 18F-FET PET Due to LAT Expression. ( 30179915 )
2018
10
Neurosarcoidosis Presenting with Obstructive Hydrocephalus Successfully Treated with Endoscopic Third Ventriculostomy. ( 30146586 )
2018
11
Optic Neuropathy and Macular Ischemia Associated with Neurosarcoidosis: A Case Report. ( 30202617 )
2018
12
Neurosarcoidosis Flare with Multifocal Restricted Diffusion: Stroke, Inflammation, or Both? ( 30055999 )
2018
13
Delayed onset of neurosarcoidosis after concurrent ipilimumab/nivolumab therapy. ( 30064495 )
2018
14
Neurosarcoidosis: clinical characteristics, diagnosis, and treatment in eight Chinese patients. ( 30088165 )
2018
15
Clinical diagnostic utility of contrast-enhanced three-dimensional fluid-attenuated inversion recovery for selection of brain biopsy sites in neurosarcoidosis: A case report. ( 30107352 )
2018
16
A Case of Neurosarcoidosis-Induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone Diagnosed with Neuroendoscopy. ( 30158982 )
2018
17
Definition and Consensus Diagnostic Criteria for Neurosarcoidosis: From the Neurosarcoidosis Consortium Consensus Group. ( 30167654 )
2018
18
Co-ocurrence of neurosarcoidosis and intrathecal reactivation of Epstein-Barr virus. ( 30172172 )
2018
19
Neurosarcoidosis following Immune Checkpoint Inhibition. ( 30186134 )
2018
20
Application of the modified Zajicek criteria to diagnose probable spinal cord neurosarcoidosis. ( 30214749 )
2018
21
Engorgement of Deep Medullary Veins in Neurosarcoidosis: A Common-Yet-Underrecognized Cerebrovascular Finding on SWI. ( 30237298 )
2018
22
Novel Use of Rituximab in Treatment of Refractory Neurosarcoidosis in an 11-Year-Old Girl. ( 30247223 )
2018
23
Neurosarcoidosis As a Rare Differential Diagnosis for Single Or Multiple Lesions of the Nervous System. ( 30295542 )
2018
24
FDG-PET abnormalities leading to the diagnosis of an unusual case of probable neurosarcoidosis. ( 30345332 )
2018
25
Neurosarcoidosis Presenting Initially as Idiopathic Vocal Cord Paralysis. ( 30360636 )
2018
26
Neurosarcoidosis. ( 30373709 )
2018
27
Successful therapy with rituximab in three patients with probable neurosarcoidosis. ( 30386436 )
2018
28
Demystifying Neurosarcoidosis and Informing Prognosis. ( 29052731 )
2017
29
Massive Neurosarcoidosis. ( 28824053 )
2017
30
The Protean Neuropsychiatric and Vestibuloauditory Manifestations of Neurosarcoidosis. ( 29166635 )
2017
31
A Rare Case of Neurosarcoidosis Presenting as Severe Hypothermia. ( 28484206 )
2017
32
Neurosarcoidosis Presenting With Recurrent Strokes: A Case Report and Literature Review. ( 28400903 )
2017
33
Neurosarcoidosis: clinical presentations and changing treatment patterns in an Irish Caucasian population. ( 28101825 )
2017
34
Search for biomarkers of neurosarcoidosis by proteomic analysis of cerebrospinal fluid. ( 28751284 )
2017
35
Propionibacterium acnes-associated neurosarcoidosis: A case report with review of the literature. ( 28856748 )
2017
36
(18)F-FDG-PET/CT guiding to diagnosis of neurosarcoidosis. ( 28219645 )
2017
37
(18)F-FDG PET/CT helps in unmasking the great mimicker: A case of neurosarcoidosis with isolated involvement of the spinal cord. ( 28526323 )
2017
38
Characteristics and Long-Term Outcome of Neurosarcoidosis: A Population-Based Study from 1976-2013. ( 28601860 )
2017
39
Extrapyramidal signs in neurosarcoidosis versus multiple sclerosis: Is TNF alpha the link? ( 29054587 )
2017
40
Nodular Leptomeningeal Enhancement in Neurosarcoidosis: Before and After Treatment. ( 28975003 )
2017
41
Neurosarcoidosis and multiple intracerebral hematomas: An unusual clinical presentation. ( 28716245 )
2017
42
Neurosarcoidosis according to Zajicek and Scolding criteria: 15 probable and definite cases, their treatment and outcomes. ( 28716286 )
2017
43
Many faces of neurosarcoidosis: from chronic meningitis to myelopathy. ( 28598872 )
2017
44
Cerebrovascular Manifestations of Neurosarcoidosis: An Underrecognized Aspect of the Imaging Spectrum. ( 29284603 )
2017
45
Association of Prognostic Factors and Immunosuppressive Treatment With Long-term Outcomes in Neurosarcoidosis. ( 29052709 )
2017
46
Neurosarcoidosis-induced longitudinal extensive transverse myelitis. ( 28879911 )
2017
47
Neurosarcoidosis. ( 28750463 )
2017
48
Long-term outcomes of refractory neurosarcoidosis treated with infliximab. ( 28260120 )
2017
49
Neurosarcoidosis on FET and FDG PET/CT. ( 28045730 )
2017
50
An unusual presentation of neurosarcoidosis with progressive hearing loss. ( 29610651 )
2017

Variations for Neurosarcoidosis

Expression for Neurosarcoidosis

Search GEO for disease gene expression data for Neurosarcoidosis.

Pathways for Neurosarcoidosis

GO Terms for Neurosarcoidosis

Sources for Neurosarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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