MCID: NRS005
MIFTS: 25

Neurosarcoidosis

Categories: Neuronal diseases

Aliases & Classifications for Neurosarcoidosis

MalaCards integrated aliases for Neurosarcoidosis:

Name: Neurosarcoidosis 54 73

Classifications:



External Ids:

UMLS 73 C0393485

Summaries for Neurosarcoidosis

NINDS : 54 Neurosarcoidosis is a manifestation of sarcoidosis in the nervous system.  Sarcoidosis is a chronic inflammatory disorder that typically occurs in adults between 20 and 40 years of age and primarily affects the lungs, but can also impact almost every other organ and system in the body.  Neurosarcoidosis is characterized by inflammation and abnormal cell deposits in any part of the nervous system – the brain, spinal cord, or peripheral nerves.  It most commonly occurs in the cranial and facial nerves, the hypothalamus (a specific area of the brain), and the pituitary gland.  It is estimated to develop in 5 to 15 percent of those individuals who have sarcoidosis.  Weakness of the facial muscles on one side of the face (Bell’s palsy) is a common symptom of neurosarcoidosis.  The optic and auditory nerves can also become involved, causing vision and hearing impairments.  It can cause headache, seizures, memory loss, hallucinations, irritability, agitation, and changes in mood and behavior.  Neurosarcoidosis can appear in an acute, explosive fashion or start as a slow chronic illness.  Because neurosarcoidosis manifests in many different ways, a diagnosis may be difficult and delayed.

MalaCards based summary : Neurosarcoidosis is related to hydrocephalus and meningitis. An important gene associated with Neurosarcoidosis is ACE (Angiotensin I Converting Enzyme). The drugs beta-endorphin and Adrenocorticotropic Hormone have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and spinal cord.

Wikipedia : 76 Neurosarcoidosis (sometimes shortened to neurosarcoid) refers to sarcoidosis, a condition of unknown... more...

Related Diseases for Neurosarcoidosis

Diseases related to Neurosarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 hydrocephalus 10.1
2 meningitis 10.1
3 diabetes insipidus 10.0
4 neuropathy 10.0
5 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
6 headache 9.9
7 multiple sclerosis 9.9
8 transverse myelitis 9.9
9 myelitis 9.9
10 cerebritis 9.9
11 amenorrhea 9.8
12 thrombosis 9.7
13 encephalitis 9.7
14 cranial nerve palsy 9.7
15 igg4-related pachymeningitis 9.7
16 rheumatoid arthritis 9.7
17 peripheral nervous system disease 9.7
18 glioma 9.7
19 idiopathic hypertrophic pachymeningitis 9.7
20 choroiditis 9.7
21 optic nerve disease 9.7
22 depression 9.7
23 arthritis 9.7
24 common variable immunodeficiency 9.7
25 multiple cranial nerve palsy 9.7
26 encephalopathy 9.7
27 hypopituitarism 9.7
28 tremor 9.7
29 amenorrhea-galactorrhea syndrome 9.6
30 papilledema 9.6
31 retinitis 9.6
32 endotheliitis 9.6
33 amyotrophic lateral sclerosis 1 9.6
34 sensorineural hearing loss 9.6
35 labyrinthitis 9.6
36 amaurosis fugax 9.6
37 chronic meningitis 9.6
38 neovascular glaucoma 9.6
39 erdheim-chester disease 9.6
40 autoimmune encephalitis 9.6
41 meningoencephalitis 9.6
42 status epilepticus 9.6
43 central nervous system vasculitis 9.6
44 charles bonnet syndrome 9.6
45 schizophrenia 9.6
46 acute cervicitis 9.6
47 epilepsy 9.6
48 thrombophilia due to thrombin defect 9.6
49 respiratory failure 9.6
50 mononeuritis multiplex 9.6

Graphical network of the top 20 diseases related to Neurosarcoidosis:



Diseases related to Neurosarcoidosis

Symptoms & Phenotypes for Neurosarcoidosis

Drugs & Therapeutics for Neurosarcoidosis

Drugs for Neurosarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 beta-endorphin Phase 4
2 Adrenocorticotropic Hormone Phase 4
3 Hormone Antagonists Phase 4
4 Hormones Phase 4
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
6 Melanocyte-Stimulating Hormones Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ACTHAR Therapy for Central Nervous System Sarcoidosis Not yet recruiting NCT02920710 Phase 4 Repository Corticotropin Injection
2 Analysis of the Distribution of Regulatory B Cells in Blood of Multiple Sclerosis Patients Recruiting NCT02789670

Search NIH Clinical Center for Neurosarcoidosis

Genetic Tests for Neurosarcoidosis

Anatomical Context for Neurosarcoidosis

MalaCards organs/tissues related to Neurosarcoidosis:

41
Brain, Lung, Spinal Cord, Pituitary, Testes, Hypothalamus, B Cells

Publications for Neurosarcoidosis

Articles related to Neurosarcoidosis:

(show top 50) (show all 475)
# Title Authors Year
1
Usefulness of 18F-FDG-PET/CT imaging in a patient with neurosarcoidosis. ( 29685313 )
2018
2
Neurosarcoidosis associated with intracerebral haemorrhage: a challenge in diagnosis and management. ( 29363557 )
2018
3
Carotid arteritis causing amaurosis fugax and ischaemic cerebrovascular events in neurosarcoidosis. ( 29653415 )
2018
4
An atypical case of neurosarcoidosis presenting with neovascular glaucoma. ( 29671151 )
2018
5
Cerebrovascular manifestations in neurosarcoidosis: how common are they and does perivascular enhancement matter? ( 29970245 )
2018
6
Not everything is as it seems: neurosarcoidosis presenting as leptomeningitis. ( 29636921 )
2018
7
Demystifying Neurosarcoidosis and Informing Prognosis. ( 29052731 )
2017
8
Massive Neurosarcoidosis. ( 28824053 )
2017
9
The Protean Neuropsychiatric and Vestibuloauditory Manifestations of Neurosarcoidosis. ( 29166635 )
2017
10
A Rare Case of Neurosarcoidosis Presenting as Severe Hypothermia. ( 28484206 )
2017
11
Neurosarcoidosis Presenting With Recurrent Strokes: A Case Report and Literature Review. ( 28400903 )
2017
12
Neurosarcoidosis: clinical presentations and changing treatment patterns in an Irish Caucasian population. ( 28101825 )
2017
13
Search for biomarkers of neurosarcoidosis by proteomic analysis of cerebrospinal fluid. ( 28751284 )
2017
14
Propionibacterium acnes-associated neurosarcoidosis: A case report with review of the literature. ( 28856748 )
2017
15
(18)F-FDG-PET/CT guiding to diagnosis of neurosarcoidosis. ( 28219645 )
2017
16
(18)F-FDG PET/CT helps in unmasking the great mimicker: A case of neurosarcoidosis with isolated involvement of the spinal cord. ( 28526323 )
2017
17
Characteristics and Long-Term Outcome of Neurosarcoidosis: A Population-Based Study from 1976-2013. ( 28601860 )
2017
18
Extrapyramidal signs in neurosarcoidosis versus multiple sclerosis: Is TNF alpha the link? ( 29054587 )
2017
19
Nodular Leptomeningeal Enhancement in Neurosarcoidosis: Before and After Treatment. ( 28975003 )
2017
20
Neurosarcoidosis and multiple intracerebral hematomas: An unusual clinical presentation. ( 28716245 )
2017
21
Neurosarcoidosis according to Zajicek and Scolding criteria: 15 probable and definite cases, their treatment and outcomes. ( 28716286 )
2017
22
Many faces of neurosarcoidosis: from chronic meningitis to myelopathy. ( 28598872 )
2017
23
Cerebrovascular Manifestations of Neurosarcoidosis: An Underrecognized Aspect of the Imaging Spectrum. ( 29284603 )
2017
24
Association of Prognostic Factors and Immunosuppressive Treatment With Long-term Outcomes in Neurosarcoidosis. ( 29052709 )
2017
25
Neurosarcoidosis-induced longitudinal extensive transverse myelitis. ( 28879911 )
2017
26
Neurosarcoidosis. ( 28750463 )
2017
27
Long-term outcomes of refractory neurosarcoidosis treated with infliximab. ( 28260120 )
2017
28
Neurosarcoidosis on FET and FDG PET/CT. ( 28045730 )
2017
29
An unusual presentation of neurosarcoidosis with progressive hearing loss. ( 29610651 )
2017
30
Neurosarcoidosis. ( 29061245 )
2017
31
"Hot-cross bun" and "inverse trident sign' in neurosarcoidosis: An important finding. ( 28084265 )
2017
32
Leptomeningeal Infiltration, the Hallmark of Neurosarcoidosis. ( 28389310 )
2017
33
Neurosarcoidosis presenting as an incidental solitary cranial ring-enhancing lesion. ( 28761540 )
2017
34
Neurosarcoidosis: leptomeninigeal, cavernous sinus and pituitary involvement. ( 28186582 )
2017
35
Neurosarcoidosis in Pediatric Patients: A Case Report and Review of Isolated and Systemic Neurosarcoidosis. ( 27524272 )
2016
36
Poster 348 Biospy-Confirmed Neurosarcoidosis Manifesting as a Non-Compressive Myelopathy with Transverse Myelitis and Normal ACE Level: A Case Study. ( 27673101 )
2016
37
Neurosarcoidosis Presenting as Aseptic Meningitis in an Immunosuppressed Renal Transplant Recipient. ( 26863472 )
2016
38
The devil is in the detail: Acute Guillain-BarrAc syndrome camouflaged as neurosarcoidosis in a critically ill patient admitted to an Intensive Care Unit. ( 27303139 )
2016
39
Isolated neurosarcoidosis presenting with multiple cranial nerve palsies. ( 27168947 )
2016
40
Isolated Central Nervous System Vasculitis as a Manifestation of Neurosarcoidosis. ( 27083067 )
2016
41
Teaching NeuroImages: Recurrent oculomotor palsies caused by neurosarcoidosis. ( 27432184 )
2016
42
Unusual Presentation of Central Diabetes Insipidus in a Patient With Neurosarcoidosis. ( 27652275 )
2016
43
NEUROSARCOIDOSIS MASQUERADING AS A CENTRAL NERVOUS SYSTEM TUMOR. ( 27571425 )
2016
44
Intractable Neurosarcoidosis Effectively Treated with Infliximab. ( 27041170 )
2016
45
Neurosarcoidosis in a Tertiary Referral Center: A Cross-Sectional Cohort Study. ( 27057889 )
2016
46
1260: NEUROSARCOIDOSIS INDUCED PANHYPOPITUITARISM. ( 26570921 )
2015
47
Hypocretin Deficiency Associated with Narcolepsy Type 1 and Central Hypoventilation Syndrome in Neurosarcoidosis of the Hypothalamus. ( 25979096 )
2015
48
Corticosteroid-resistant bulbar neurosarcoidosis responsive to intravenous immunoglobulin. ( 25935926 )
2015
49
A CASE OF PROBABLE NEUROSARCOIDOSIS PRESENTING AS UNILATERAL OPHTHALMOPLEGIA. ( 26666108 )
2015
50
Hashimoto encephalopathy or neurosarcoidosis? A case report. ( 25829987 )
2015

Variations for Neurosarcoidosis

Expression for Neurosarcoidosis

Search GEO for disease gene expression data for Neurosarcoidosis.

Pathways for Neurosarcoidosis

GO Terms for Neurosarcoidosis

Sources for Neurosarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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