Neurosarcoidosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: NRS005 MIFTS: 32	Neurosarcoidosis Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Neurosarcoidosis

MalaCards integrated aliases for Neurosarcoidosis:

Name: Neurosarcoidosis ¹² ⁵³ ¹⁵ ⁷⁰

Cerebral Sarcoidosis ¹² ⁷⁰

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:13403

NCIt ⁵⁰ C35441

SNOMED-CT ⁶⁷ 111936002

UMLS ⁷⁰ C0393485 C0398676

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Summaries for Neurosarcoidosis

NINDS : ⁵³ Neurosarcoidosis is a manifestation of sarcoidosis in the nervous system. Sarcoidosis is a chronic inflammatory disorder that typically occurs in adults between 20 and 40 years of age and primarily affects the lungs, but can also impact almost every other organ and system in the body. Neurosarcoidosis is characterized by inflammation and abnormal cell deposits in any part of the nervous system – the brain, spinal cord, or peripheral nerves. It most commonly occurs in the cranial and facial nerves, the hypothalamus (a specific area of the brain), and the pituitary gland. It is estimated to develop in 5 to 15 percent of those individuals who have sarcoidosis. Weakness of the facial muscles on one side of the face (Bell’s palsy) is a common symptom of neurosarcoidosis. The optic and auditory nerves can also become involved, causing vision and hearing impairments. It can cause headache, seizures, memory loss, hallucinations, irritability, agitation, and changes in mood and behavior. Neurosarcoidosis can appear in an acute, explosive fashion or start as a slow chronic illness. Because neurosarcoidosis manifests in many different ways, a diagnosis may be difficult and delayed.

MalaCards based summary : Neurosarcoidosis, also known as cerebral sarcoidosis, is related to neuritis and optic neuritis. An important gene associated with Neurosarcoidosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Yersinia infection and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include pituitary, spinal cord and hypothalamus.

Disease Ontology : ¹² A sarcoidosis that is characterized by involvement of the nervous symptom with cranial nerve palsy, diffuse meningeal disease, acute polyneuropathy, myelitis, or hypothalamic pituitary axis malformation, develops from a type IV hypersensitivity reaction with noncaseating granulomas involving the nervous system.

Wikipedia : ⁷³ Neurosarcoidosis (sometimes shortened to neurosarcoid) refers to a type of sarcoidosis, a condition of... more...

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Related Diseases for Neurosarcoidosis

Diseases related to Neurosarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 649)

#	Related Disease	Score	Top Affiliating Genes
1	neuritis	30.5	TNF MOG AQP4
2	optic neuritis	30.4	TNF MOG AQP4
3	myelitis	30.4	TNF MOG AQP4
4	sarcoidosis 1	30.3	TNF CRP CD8A CD4 ACE
5	transverse myelitis	30.2	TNF MOG AQP4
6	polyneuropathy	30.0	TNF CRP ACE
7	multiple cranial nerve palsy	30.0	CRP ACE
8	acute disseminated encephalomyelitis	30.0	PNMA2 MOG AQP4
9	granulomatous angiitis	30.0	CRP ACE
10	meningitis	30.0	TNF CRP AQP4
11	chronic meningitis	30.0	MIR642A CRP CD4
12	inappropriate adh syndrome	29.9	AQP4 ACE
13	internuclear ophthalmoplegia	29.9	MOG AQP4
14	tolosa-hunt syndrome	29.9	CRP ACE
15	cranial nerve palsy	29.7	CRP CD4 AQP4 ACE
16	encephalitis	29.7	TNF PNMA2 MOG AQP4
17	papilledema	29.6	CRP CD4 AQP4 ACE
18	skin sarcoidosis	29.6	TNF CD8A CD4 ACE
19	cerebral lymphoma	29.6	CD8A CD4
20	choroiditis	29.6	TNF CD4 ACE
21	mononeuropathy	29.6	TNF CRP CD4
22	retinal vasculitis	29.6	TNF CD4 ACE
23	bell's palsy	29.5	CD8A CD4
24	central nervous system tuberculosis	29.5	TNF MIR642A CD4
25	raynaud disease	29.5	CRP ACE
26	bacterial meningitis	29.4	TNF CRP AQP4
27	iridocyclitis	29.4	TNF CRP CD4 ACE
28	arachnoiditis	29.4	TNF CRP CD4 AQP4
29	autoimmune disease	29.3	TNF MOG CRP AQP4
30	multiple sclerosis	29.3	TNF MOG CD8A CD4 AQP4
31	sleep apnea	29.3	TNF CRP ACE
32	mononeuritis multiplex	29.3	TNF CRP CD4 ACE
33	facial paralysis	29.3	TNF CRP CD8A CD4 ACE
34	corneal disease	29.2	TNF CD8A CD4
35	stroke, ischemic	29.2	TNF CRP AQP4 ACE
36	glucose intolerance	29.2	TNF CRP ACE
37	meningoencephalitis	29.2	TNF CRP CD8A CD4
38	optic nerve disease	29.2	TNF MOG CRP CD4 AQP4
39	uveoparotid fever	29.1	TNF CD8A CD4 ACE
40	central nervous system vasculitis	29.1	TNF CRP CD8A CD4
41	end stage renal disease	29.1	TNF CRP ACE
42	lung disease	29.0	TNF CRP CD8A ACE
43	respiratory failure	28.9	TNF CRP CD8A CD4 ACE
44	optic papillitis	28.9	MOG CRP CD4 AQP4 ACE
45	urticaria	28.9	CRP CD4 ACE TNF
46	panuveitis	28.8	TNF CRP CD8A CD4 ACE
47	peripheral nervous system disease	28.7	TNF MOG CRP CD8A CD4 AQP4
48	demyelinating disease	28.7	TNF MOG CD8A CD4 AQP4
49	chickenpox	28.6	TNF CRP CD8A CD4
50	disease by infectious agent	28.6	TNF CRP CD8A CD4

Graphical network of the top 20 diseases related to Neurosarcoidosis:

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Symptoms & Phenotypes for Neurosarcoidosis

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Drugs & Therapeutics for Neurosarcoidosis

Search Clinical Trials , NIH Clinical Center for Neurosarcoidosis

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Genetic Tests for Neurosarcoidosis

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Anatomical Context for Neurosarcoidosis

MalaCards organs/tissues related to Neurosarcoidosis:

⁴⁰

Pituitary, Spinal Cord, Hypothalamus, Medulla Oblongata, Pineal, Eye, Brain

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Publications for Neurosarcoidosis

Articles related to Neurosarcoidosis:

(show top 50) (show all 1102)

#	Title	Authors	PMID	Year
1	A rare case of spinal epidural sarcoidosis: case report and review of the literature. ⁶¹	Paglia F...Santoro A	31297669	2021
2	Infliximab for relapsing neurosarcoidosis recurring after kidney transplantation: a case report. ⁶¹	Hanset N...Kanaan N	31486719	2021
3	Cochlear Implantation in Sporadic Vestibular Schwannoma and Other Retrocochlear Pathology: A Case Series. ⁶¹	Patel EJ...Roland JT	33351558	2021
4	Neurosarcoidosis presenting as isolated VI nerve palsy. ⁶¹	Kimmitt CM...Camara-Lemarroy CR	33095367	2021
5	Tumour necrosis factor inhibitor monotherapy for CNS neurosarcoidosis. ⁶¹	Gelfand JM	33785576	2021
6	Diabetes insipidus secondary to sellar/parasellar lesions. ⁶¹	Angelousi A...Kaltsas G	33769630	2021
7	Intracranial Tuberculoma Mimicking Neurosarcoidosis: A Clinical Challenge. ⁶¹	Abbasi F...Whitman MS	33804334	2021
8	Neurosarcoidosis with parenchymal nodules aligned in the temporal lobe. ⁶¹	Demir MK...Kilic T	33755183	2021
9	Neurosarcoidosis - a patient series. ⁶¹	Borhaug E...Vedeler CA	33754685	2021
10	Neurosarcoidosis Masquerading as Giant Cell Arteritis With Incidental Meningioma. ⁶¹	Solyman OM...Henderson AD	32441899	2021
11	Overcoming the Elusiveness of Neurosarcoidosis: Learning from Five Complex Cases. ⁶¹	Feizi P...Sriwastava S	33805852	2021
12	A 46-Year-Old Presenting With Inferior Mononuclear Visual Field Defect as the Sole Manifestation of Neurosarcoidosis. ⁶¹	Hoegerl C...Amper A	33728109	2021
13	Elevated Neurofilament Light Chain in Cerebrospinal Fluid and Plasma Reflect Inflammatory MRI Activity in Neurosarcoidosis. ⁶¹	Byg KE...Ellingsen T	33672795	2021
14	Tumefactive multiple sclerosis (TMS): A case series of this challenging variant of MS. ⁶¹	Villarreal JV...Gogia B	33373797	2021
15	Minocycline and Cephalexin in a Patient with Spastic Neuropathic Pain Secondary to Neurosarcoidosis. ⁶¹	Mohan A...Chang E	33560414	2021
16	Acute central nervous system vasculitis as a manifestation of neurosarcoidosis: A case report and literature review. ⁶¹	Maekawa T...Fujii A	33354273	2021
17	Letter to the Editor regarding "Endoscopic Management for Recurrent Hydrocephalus Associated with Neurosarcoidosis". ⁶¹	Di Perna G...Pavanello M	33607737	2021
18	Neurosarcoidosis Directly Involving the Cervical Vagus Nerve. ⁶¹	Crossley JR...Hoa M	32659110	2021
19	Neuroimaging of Spinal Cord and Cauda Equina Disorders. ⁶¹	Diehn FE...Krecke KN	33522744	2021
20	Cortical Vein Thrombosis, Tortuous Venous Vasculature, and Microhemorrhages in Neurosarcoidosis. ⁶¹	Kammeyer R...Schreiner T	33587111	2021
21	MRI signs of CNS demyelinating diseases. ⁶¹	Etemadifar M...Abhari AP	33310421	2021
22	Effects of immunotherapies and clinical outcomes in neurosarcoidosis: a retrospective cohort study. ⁶¹	Arun T...Palace J	33515298	2021
23	Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural Lipomatosis. ⁶¹	Jaafar N...Makki A	33604089	2021
24	Teaching NeuroImages: Spinal Neurosarcoidosis: An Eccentric Manifestation. ⁶¹	French D...Dunham SR	32907959	2021
25	Unexpected diagnosis of metastatic breast carcinoma in an endomyocardial biopsy done for cardiac allograft rejection evaluation. ⁶¹	Nair V...Veinot JP	32814149	2021
26	Tuberculous perihepatic abscess and neurosarcoidosis: report of 2 uncommon manifestations of 2 common granulomatous diseases in 1 patient. ⁶¹	Gernert JA...Schulz C	33429450	2021
27	Molecular Association of Medulloblastoma and Sarcoidosis: Case Report and Review of the Literature. ⁶¹	Elarjani T...Hassounah M	33010513	2021
28	Spontaneous dissolution of a cyst located within the septum pellucidum in a patient with sarcoidosis: a case report. ⁶¹	Loft MK...Pedersen MRV	33489313	2021
29	A multi-center case series of sarcoid optic neuropathy. ⁶¹	Webb LM...Flanagan EP	33358503	2021
30	An unusual presentation of neurosarcoidosis: Concurrent optic perineuritis and optic neuritis. ⁶¹	Lin MY...Dattilo M	33767965	2021
31	FLT-PET for the assessment of systemic sarcoidosis including cardiac and CNS involvement: a prospective study with comparison to FDG-PET. ⁶¹	Martineau P...Birnie D	33301054	2020
32	Heerfordt-Waldenström Syndrome. ⁶¹	Mahajan SK...Raina R	33247650	2020
33	Endoscopic Management for Recurrent Hydrocephalus Associated with Neurosarcoidosis. ⁶¹	Togashi S...Shimizu H	32890842	2020
34	A case of Mycobacterium bovis Bacillus Calmette-Guérin (BCG) strain meningitis and ventriculitis following BCG vaccination. ⁶¹	Furuichi M...Suganuma E	32976992	2020
35	Central Nervous System Lymphoma Masquerading as Neurosarcoidosis. ⁶¹	Arakawa A...Maeda N	33191325	2020
36	Probable neurosarcoidosis presenting as acute on chronic otorrhoea: a difficult diagnosis. ⁶¹	Somani SN...Matsuoka AJ	33139371	2020
37	Frequency and etiology of acute transverse myelitis in Southern Finland. ⁶¹	Smith E...Airas L	33059215	2020
38	Incidental Finding of a Duplicated Vertebral Artery Followed by a Spinal Dural Arteriovenous Fistula on Spinal Angiography. ⁶¹	Mugge L...Crimmins M	33304686	2020
39	Neurosarcoidosis presenting with isolated intracranial mass lesion and communicating hydrocephalus. ⁶¹	Novo-Gonzalez B...Alberdi-Vinas J	31882303	2020
40	Neurosarcoidosis in acute inpatient rehabilitation: a case study. ⁶¹	Nicolosi C...Niehaus W	33139707	2020
41	Cerebrospinal fluid CD4+ /CD8+ ratio in diagnosing neurosarcoidosis. ⁶¹	Nordstrom S...Malmestrom C	32533774	2020
42	Hypothalamic-Pituitary Axis Dysfunction, Central Diabetes Insipidus, and Syndrome of Inappropriate Antidiuretic Hormone Secretion as the First Clinical Presentation of Neurosarcoidosis: Why Early Diagnosis and Treatment is Important? ⁶¹	Blazin T...Mostafa JA	33329977	2020
43	A Case of Neurosarcoidosis Mimicking Brain Tumor. ⁶¹	Sari L...Alkan A	33213326	2020
44	Neurosarcoidosis: Analysis of a series of 20 patients. ⁶¹	Carazo Barrios L...Garcia Martin G	32564930	2020
45	Neurosarcoidosis presenting with hypopituitarism. ⁶¹	Liu E...AlMehthel M	33012710	2020
46	A Case of Central Diabetes Insipidus Secondary to Neurosarcoidosis. ⁶¹	Johns CE...Johns CS	33240714	2020
47	Neurosarcoidosis and Ocular Inflammation: A Case Series and Literature Review. ⁶¹	Desai A...Berkenstock M	33136665	2020
48	Neurosarcoidosis As a Rare Differential Diagnosis for Single Or Multiple Lesions of the Nervous System. ⁶¹	Blume C...Send T	30295542	2020
49	The effect of race on clinical presentation and outcomes in neurosarcoidosis. ⁶¹	Affan M...Cerghet M	32771711	2020
50	Neuro-Ophthalmic Manifestations of Sarcoidosis. ⁶¹	Henderson AD...Carey AR	33110001	2020

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Genes for Neurosarcoidosis

Genes related to Neurosarcoidosis (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ACE	Angiotensin I Converting Enzyme	Protein Coding	15.12	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	SAMMSON	Survival Associated Mitochondrial Melanoma Specific Oncogenic Non-Coding RNA	RNA Gene	11.34	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	MIR622	MicroRNA 622	RNA Gene	10.75	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	MIR642A	MicroRNA 642a	RNA Gene	7.21	DISEASES inferred ¹⁵ ¹⁵
5	AQP4	Aquaporin 4	Protein Coding	6.39	DISEASES inferred ¹⁵
6	PNMA2	PNMA Family Member 2	Protein Coding	6.05	DISEASES inferred ¹⁵
7	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	5.89	DISEASES inferred ¹⁵
8	TNF	Tumor Necrosis Factor	Protein Coding	5.86	DISEASES inferred ¹⁵
9	CD4	CD4 Molecule	Protein Coding	5.84	DISEASES inferred ¹⁵
10	CD8A	CD8a Molecule	Protein Coding	5.58	DISEASES inferred ¹⁵
11	CRP	C-Reactive Protein	Protein Coding	5.38	DISEASES inferred ¹⁵
12	ZNF592	Zinc Finger Protein 592	Protein Coding	5.33	DISEASES inferred ¹⁵

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Variations for Neurosarcoidosis

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Expression for Neurosarcoidosis

Search GEO for disease gene expression data for Neurosarcoidosis.

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Pathways for Neurosarcoidosis

Pathways related to Neurosarcoidosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Yersinia infection ³⁶	11.63	TNF CD8A CD4
2	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.5	TNF CD8A CD4
3	Hematopoietic cell lineage ³⁶	11.33	TNF CD8A CD4
4	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.03	TNF CD8A CD4
5	Dendritic Cells Developmental Lineage Pathway ⁶⁴	10.67	TNF CD8A CD4
6	Overview of nanoparticle effects ¹	10.65	TNF CRP

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GO Terms for Neurosarcoidosis

Cellular components related to Neurosarcoidosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.1	TNF MOG CD8A CD4 AQP4 ACE

Biological processes related to Neurosarcoidosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of lipid storage	GO:0010888	8.62	TNF CRP

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Sources for Neurosarcoidosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia