Neurosarcoidosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

NINDS: ⁵² Neurosarcoidosis is a manifestation of sarcoidosis in the nervous system. Sarcoidosis is a chronic inflammatory disorder that typically occurs in adults between 20 and 40 years of age and primarily affects the lungs, but can also impact almost every other organ and system in the body. Neurosarcoidosis is characterized by inflammation and abnormal cell deposits in any part of the nervous system – the brain, spinal cord, or peripheral nerves. It most commonly occurs in the cranial and facial nerves, the hypothalamus (a specific area of the brain), and the pituitary gland. It is estimated to develop in 5 to 15 percent of those individuals who have sarcoidosis. Weakness of the facial muscles on one side of the face (Bell’s palsy) is a common symptom of neurosarcoidosis. The optic and auditory nerves can also become involved, causing vision and hearing impairments. It can cause headache, seizures, memory loss, hallucinations, irritability, agitation, and changes in mood and behavior. Neurosarcoidosis can appear in an acute, explosive fashion or start as a slow chronic illness. Because neurosarcoidosis manifests in many different ways, a diagnosis may be difficult and delayed.

MalaCards based summary: Neurosarcoidosis, also known as cerebral sarcoidosis, is related to sarcoidosis 1 and meningitis. An important gene associated with Neurosarcoidosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Innate Lymphoid Cells Differentiation and Network map of SARS-CoV-2 signaling pathway. Affiliated tissues include spinal cord, pituitary and hypothalamus.

Disease Ontology: ¹¹ A sarcoidosis that is characterized by involvement of the nervous symptom with cranial nerve palsy, diffuse meningeal disease, acute polyneuropathy, myelitis, or hypothalamic pituitary axis malformation, develops from a type IV hypersensitivity reaction with noncaseating granulomas involving the nervous system.

Wikipedia: ⁷⁵ Neurosarcoidosis (sometimes shortened to neurosarcoid) refers to a type of sarcoidosis, a condition of... more...

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Related Diseases for Neurosarcoidosis

Diseases related to Neurosarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 794)

#	Related Disease	Score	Top Affiliating Genes
1	sarcoidosis 1	30.7	TNF PRTN3 CRP CD8A CD68 CD4
2	meningitis	30.7	TNF CRP AQP4
3	glanders	30.7	CD8A CD4
4	neuritis	30.6	TNF MOG DPYSL5 AQP4
5	optic neuritis	30.6	TNF MOG DPYSL5 AQP4
6	bell's palsy	30.6	TNF CRP CD8A CD4 ACE
7	intracranial hypertension	30.5	TNF CRP AQP4 ACE
8	aseptic meningitis	30.3	TNF MOG CRP CD8A CD4
9	skin sarcoidosis	30.2	TNF CD8A CD4 ACE
10	multiple sclerosis	30.2	TNF MOG CD8A CD4 AQP4
11	papilledema	30.2	MOG CRP CD4 AQP4 ACE
12	sarcoid meningitis	30.2	MOG AQP4 ACE
13	arachnoiditis	30.2	TNF CRP CD4 AQP4
14	myelitis	30.2	TNF MOG DPYSL5 AQP4 AMPH
15	cauda equina syndrome	30.2	TNF TBL2 CRP
16	posterior uveitis	30.1	TNF CD4 ACE
17	meningoencephalitis	30.1	TNF MOG CRP CD8A CD4
18	uveoparotid fever	30.1	CD4 ACE
19	labyrinthitis	30.1	TNF CRP
20	anterior uveitis	30.0	TNF CRP CD8A CD4 ACE
21	tolosa-hunt syndrome	30.0	PRTN3 CRP ACE
22	spinal cord disease	30.0	TNF MOG LGI1 DPYSL5 CD8A CD4
23	mononeuropathy	30.0	TNF PRTN3 CRP CD4 ACE
24	respiratory failure	30.0	TNF CRP CD8A CD4 ACE
25	multiple cranial nerve palsy	30.0	PRTN3 CRP CD4 ACE
26	internuclear ophthalmoplegia	29.9	PNMA2 MOG AQP4
27	retinal vasculitis	29.9	TNF CD4 ACE
28	hypertensive retinopathy	29.9	CRP ACE
29	birdshot chorioretinopathy	29.9	TNF CD8A CD4
30	brain stem infarction	29.8	PRTN3 CRP
31	fungal infectious disease	29.8	TNF CRP CD8A CD4
32	apnea, obstructive sleep	29.8	TNF CRP ACE
33	central nervous system tuberculosis	29.8	TNF CRP CD4
34	panuveitis	29.8	TNF CRP CD8A CD4 ACE
35	invasive aspergillosis	29.8	TNF CRP CD4
36	corneal disease	29.8	TNF CD8A CD4
37	scleritis	29.8	TNF PRTN3 CRP
38	demyelinating disease	29.7	TNF MOG CD8A CD4 AQP4
39	mastoiditis	29.7	PRTN3 CRP CD4
40	lateral medullary syndrome	29.7	PRTN3 PNMA2 CRP
41	juvenile rheumatoid arthritis	29.7	TNF CRP CD4
42	cranial nerve palsy	29.7	TNF PRTN3 MOG CRP CD4 AQP4
43	facial paralysis	29.7	TNF PRTN3 MOG CRP CD8A CD4
44	inappropriate adh syndrome	29.7	LGI1 CRP AQP4 ACE
45	extrapulmonary tuberculosis	29.7	TNF CRP CD8A CD4
46	cerebellopontine angle meningioma	29.7	DPYSL5 AMPH
47	polyradiculopathy	29.7	LGI1 DPYSL5 CD4 AMPH
48	vogt-koyanagi-harada disease	29.7	TNF CD8A CD4 ACE
49	mononeuritis multiplex	29.7	TNF PRTN3 DPYSL5 CRP CD4
50	choroiditis	29.7	TNF CRP CD4 ACE

Graphical network of the top 20 diseases related to Neurosarcoidosis:

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Symptoms & Phenotypes for Neurosarcoidosis

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Drugs & Therapeutics for Neurosarcoidosis

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Neurosarcoidosis : Initial Presentation and Disease Course, a Multicenter Retrospective Study	Recruiting	NCT04911348

Search NIH Clinical Center for Neurosarcoidosis

Cochrane evidence based reviews: neurosarcoidosis

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Genetic Tests for Neurosarcoidosis

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Anatomical Context for Neurosarcoidosis

Organs/tissues related to Neurosarcoidosis:

MalaCards : Spinal Cord, Pituitary, Hypothalamus, Brain, Lung, Medulla Oblongata, Lymph Node

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Publications for Neurosarcoidosis

Articles related to Neurosarcoidosis:

(show top 50) (show all 1215)

#	Title	Authors	PMID	Year
1	Sarcoidosis and obsessive-compulsive symptoms. ⁶²	Endres D...Tebartz van Elst L	36308776	2022
2	Neurosarcoidosis: A call to arms. ⁶²	Hardy TA...Clifford DB	36283148	2022
3	Neurosarcoidosis resembling multiple meningioma and manifesting as arrhythmia: a case report. ⁶²	Xu J...Wang Y	34826126	2022
4	Neurosarcoidosis: Phenotypes, Approach to Diagnosis and Treatment. ⁶²	Gosselin J...Nevares A	36223002	2022
5	Presumptive isolated neurosarcoidosis involving eloquent structures: An argument for empirical TNF-α inhibition. ⁶²	Law LY...Reddel SW	36054936	2022
6	Immune-mediated Cerebellar Ataxia with Neurosarcoidosis. ⁶²	Mizushima K...Yabe I	36384902	2022
7	Management of neurosarcoidosis. ⁶²	Kidd DP	36162337	2022
8	Pachymeningitis in Biopsy-Proven Sarcoidosis: Clinical Course, Radiographic Findings, Response to Treatment, and Long-term Outcomes. ⁶²	Chakales PA...Hutto SK	36163175	2022
9	Genetics of neurosarcoidosis. ⁶²	Hardin A...Montgomery C	36054933	2022
10	Ischemic stroke in neurosarcoidosis: A retrospective cohort analysis. ⁶²	Hutto SK...Venna N	36240703	2022
11	Symptomatic Gastric Sarcoidosis in a Patient with Pulmonary and Neurosarcoidosis: A Case Report. ⁶²	Hassan D...Patel N	36190928	2022
12	Cochlear Implantation Outcomes in Patients With Retrocochlear Pathology: A Systematic Review and Pooled Analysis. ⁶²	Schlacter JA...Roland JT	36047686	2022
13	Controversies in neuroimmunology: multiple sclerosis, vaccination, SARS-CoV-2 and other dilemas ⁶²	Reyes-Nino S...Toro-Gomez J	36322548	2022
14	Neurosarcoidosis in children: A systematic review and summary of cases, imaging and management. ⁶²	Young M...Gombolay G	35944453	2022
15	Facial nerve palsy in neurosarcoidosis: clinical course, neuroinflammatory accompaniments, ancillary investigations, and response to treatment. ⁶²	Nwebube CO...Hutto SK	35583659	2022
16	Neurosarcoidosis during the treatment of primary Sjögren's syndrome: is it a paradoxical effect of rituximab? ⁶²	Cordeiro RA...Pasoto SG	36226627	2022
17	Hit-hard and early versus step-up treatment in severe sarcoidosis. ⁶²	Vorselaars ADM...Culver DA	35869744	2022
18	A Rare Case of Neurosarcoidosis Overlapped with Sjogren's Syndrome. ⁶²	Cai W...Li Z	36233588	2022
19	An Unusual Presentation of Neurosarcoidosis. ⁶²	Sarac E...Arif A	36164269	2022
20	Neurosarcoidosis: an update on diagnosis and therapy. ⁶²	Ungprasert P...Culver DA	35914766	2022
21	Granulomatous vasculitis presenting as annular erythema in neurosarcoidosis. ⁶²	Karakida K...Komatsu A	35040940	2022
22	Distinguishing CNS neurosarcoidosis from multiple sclerosis and an approach to "overlap" cases. ⁶²	Chan F...Hardy TA	35689980	2022
23	Relevance of Medullary Vein Sign in Neurosarcoidosis. ⁶²	Liberio R...Sriwastava S	35997361	2022
24	A prospective, one-year follow-up study of patients newly diagnosed with neurosarcoidosis. ⁶²	Byg KE...Ellingsen T	35717739	2022
25	Acute Venous Congestive Myelopathy in a Patient with Neurosarcoidosis. ⁶²	Guy NH	36188492	2022
26	Neurosarcoidosis of the Cauda Equina: Clinical Course, Radiographic and Electrodiagnostic Findings, Response to Treatment, and Outcomes. ⁶²	Bou GA...Hutto SK	35487693	2022
27	Clinical features and diagnosis of neurosarcoidosis - review article. ⁶²	Barreras P...Stern BJ	35523055	2022
28	Clinical characteristics and outcome of neurosarcoidosis-associated myelitis: A retrospective cohort study and review of the literature. ⁶²	Nolte JYC...Brouwer MC	35189010	2022
29	The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells. ⁶²	Paley MA...Yokoyama WM	35405431	2022
30	The blood-CSF-brain route of neurological disease: The indirect pathway into the brain. ⁶²	Cousins O...Roncaroli F	34935179	2022
31	"The Invisible Corset": A Rare Manifestation of Neurosarcoidosis. ⁶²	Fukushima K...Takei YI	35705277	2022
32	Inflammatory profiles in plasma and cerebrospinal fluid of patients with neurosarcoidosis. ⁶²	Byg KE...Nielsen HH	35366560	2022
33	Worsening Paraparesis: A Diagnostic Dilemma for Neurosarcoidosis. ⁶²	Stroia A...Meseeha M	35720784	2022
34	[Panhypopituitarism as the first manifestation of sarcoidosis: case report]. ⁶²	Ukhanova YA...Terpigorev SA	36104964	2022
35	Imaging Findings of Concomitant Pulmonary and Central Nervous System Sarcoidosis: A Case Report. ⁶²	Balcha TE...Aboye AG	35813678	2022
36	[Steroid-Resistant Central Nervous System Sarcoidosis: Use of Immunosuppressants and Biologic Drugs]. ⁶²	Kuroda H	35589630	2022
37	Intracranial necrotising sarcoid granulomatosis mimicking petroclival meningioma. ⁶²	Valappil A...Ahamed Tp J	35580943	2022
38	Neurosarcoidosis Presenting with Prominent Periventricular White-Matter Lesions during Steroid Treatment for Autoimmune Hepatitis. ⁶²	Shibahara T...Nakane H	36160653	2022
39	Teaching Video NeuroImage: Parinaud Syndrome Due to Ventriculoperitoneal Shunt Malfunction in a Patient With Neurosarcoidosis. ⁶²	Frank A...Schaefer J	35379760	2022
40	Clinical characteristics and outcome of hydrocephalus in neurosarcoidosis: a retrospective cohort study and review of the literature. ⁶²	Ten Dam L...Brouwer MC	34743227	2022
41	Discussing Challenges in Diagnosis of Tuberculous Meningitis and Neurosarcoidosis. ⁶²	Santos A...Pantazou V	34165067	2022
42	Neurosarcoidosis Presenting as Ophthalmoplegic Headache Managed With Acetazolamide. ⁶²	Trenz ME...Zakin E	35483067	2022
43	The need for a broad differential: intramedullary neurosarcoidosis case report. ⁶²	Luy DD...Gerszten PC	35128591	2022
44	Prognostic Factors and Treatment Efficacy in Spinal Cord Sarcoidosis: An Observational Cohort With Long-term Follow-up. ⁶²	Gavoille A...Seve P	35145013	2022
45	Isolated CNS Sarcoidosis Versus Systemic Sarcoidosis With CNS Involvement: A Same Disease? ⁶²	Courtin E...Duffau P	35419160	2022
46	Adalimumab for CNS sarcoidosis: single-center experience and literature review. ⁶²	Hutto SK...Venna N	34487233	2022
47	PATHOLOGICALLY-CONFIRMED ISOLATED HYPOTHALAMO-PITUITARY SARCOIDOSIS REFRACTORY TO PULSE-DOSE GLUCOCORTICOIDS AND SUCCESSFULLY TREATED WITH METHOTREXATE. ⁶²	Borawski B...Witek P	36212266	2022
48	Neurosarcoidosis: A Case Report. ⁶²	Nascimento ML...Araujo P	35651406	2022
49	Very Delayed Onset of Neurosarcoidosis After Isolated Optic Perineuritis. ⁶²	Donaldson L...Rodriguez AR	33843524	2022
50	A Rare Case of Epstein-Barr Virus-Positive T-Cell Lymphoma in the Skin of an Immunocompromised Patient. ⁶²	van Eijk LE...Diercks GFH	35076433	2022

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Genes for Neurosarcoidosis

Genes related to Neurosarcoidosis (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ACE	Angiotensin I Converting Enzyme	Protein Coding	7.77	DISEASES inferred ¹⁴
2	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	6.69	DISEASES inferred ¹⁴
3	AQP4	Aquaporin 4	Protein Coding	6.65	DISEASES inferred ¹⁴
4	TNF	Tumor Necrosis Factor	Protein Coding	5.96	DISEASES inferred ¹⁴
5	CD4	CD4 Molecule	Protein Coding	5.74	DISEASES inferred ¹⁴
6	PNMA2	PNMA Family Member 2	Protein Coding	5.62	DISEASES inferred ¹⁴
7	CD8A	CD8a Molecule	Protein Coding	5.58	DISEASES inferred ¹⁴
8	DPYSL5	Dihydropyrimidinase Like 5	Protein Coding	5.4	DISEASES inferred ¹⁴
9	CRP	C-Reactive Protein	Protein Coding	5.37	DISEASES inferred ¹⁴
10	PRTN3	Proteinase 3	Protein Coding	5.18	DISEASES inferred ¹⁴
11	ZNF592	Zinc Finger Protein 592	Protein Coding	5.16	DISEASES inferred ¹⁴
12	SAMMSON	Survival Associated Mitochondrial Melanoma Specific Oncogenic Non-Coding RNA	RNA Gene	5.08	DISEASES inferred ¹⁴
13	CD68	CD68 Molecule	Protein Coding	5.02	DISEASES inferred ¹⁴
14	AMPH	Amphiphysin	Protein Coding	4.97	DISEASES inferred ¹⁴
15	TBL2	Transducin Beta Like 2	Protein Coding	4.89	DISEASES inferred ¹⁴
16	LGI1	Leucine Rich Glioma Inactivated 1	Protein Coding	4.87	DISEASES inferred ¹⁴

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Variations for Neurosarcoidosis

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Expression for Neurosarcoidosis

Search GEO for disease gene expression data for Neurosarcoidosis.

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Pathways for Neurosarcoidosis

Pathways related to Neurosarcoidosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Lymphoid Cells Differentiation ⁶⁵	11.34	TNF CD8A CD4
2	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.22	CRP CD8A CD4
3	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11	TNF CD8A CD4
4	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	10.99	TNF CD8A CD68 CD4
5	LDL Oxidation in Atherogenesis ⁶⁴	10.53	TNF CD68

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GO Terms for Neurosarcoidosis

Cellular components related to Neurosarcoidosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.4	TNF MOG CD8A CD4 AQP4 ACE

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Sources for Neurosarcoidosis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: NRS005 MIFTS: 34	Neurosarcoidosis Categories: Immune diseases	Data Licensing For inquiries, contact: [email protected]
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