MCID: NRS005
MIFTS: 35

Neurosarcoidosis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Neurosarcoidosis

MalaCards integrated aliases for Neurosarcoidosis:

Name: Neurosarcoidosis 12 55 15 74
Cerebral Sarcoidosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13403
NCIt 51 C35441

Summaries for Neurosarcoidosis

NINDS : 55 Neurosarcoidosis is a manifestation of sarcoidosis in the nervous system.  Sarcoidosis is a chronic inflammatory disorder that typically occurs in adults between 20 and 40 years of age and primarily affects the lungs, but can also impact almost every other organ and system in the body.  Neurosarcoidosis is characterized by inflammation and abnormal cell deposits in any part of the nervous system – the brain, spinal cord, or peripheral nerves.  It most commonly occurs in the cranial and facial nerves, the hypothalamus (a specific area of the brain), and the pituitary gland.  It is estimated to develop in 5 to 15 percent of those individuals who have sarcoidosis.  Weakness of the facial muscles on one side of the face (Bell’s palsy) is a common symptom of neurosarcoidosis.  The optic and auditory nerves can also become involved, causing vision and hearing impairments.  It can cause headache, seizures, memory loss, hallucinations, irritability, agitation, and changes in mood and behavior.  Neurosarcoidosis can appear in an acute, explosive fashion or start as a slow chronic illness.  Because neurosarcoidosis manifests in many different ways, a diagnosis may be difficult and delayed.

MalaCards based summary : Neurosarcoidosis, also known as cerebral sarcoidosis, is related to meningitis and granulomatous angiitis. An important gene associated with Neurosarcoidosis is ACE (Angiotensin I Converting Enzyme). The drugs Hormones and beta-endorphin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and pituitary, and related phenotype is neoplasm.

Disease Ontology : 12 A sarcoidosis that is characterized by involvement of the nervous symptom with cranial nerve palsy, diffuse meningeal disease, acute polyneuropathy, myelitis, or hypothalamic pituitary axis malformation, develops_from a type IV hypersensitivity reaction with noncaseating granulomas involving the nervous system.

Wikipedia : 77 Neurosarcoidosis (sometimes shortened to neurosarcoid) refers to sarcoidosis, a condition of unknown... more...

Related Diseases for Neurosarcoidosis

Diseases related to Neurosarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 meningitis 30.1 LYZ TNF
2 granulomatous angiitis 29.9 ACE HYLS1
3 central nervous system vasculitis 29.6 SMUG1 TNF
4 pulmonary sarcoidosis 29.5 ACE TNF
5 tuberculous meningitis 29.5 LYZ TNF
6 nervous system disease 29.2 ACE SMUG1 TNF
7 respiratory failure 29.2 ACE TNF
8 hydrocephalus 10.3
9 diabetes insipidus 10.2
10 anthracosilicosis 10.2 ACE SMUG1
11 neuropathy 10.2
12 neuroretinitis 10.2 ACE LYZ
13 granulomatous myositis 10.1 LYZ SMUG1
14 laryngeal tuberculosis 10.1 LYZ SMUG1
15 xanthogranulomatous pyelonephritis 10.1 LYZ SMUG1
16 xanthogranulomatous cholecystitis 10.1 LYZ SMUG1
17 in situ pulmonary adenocarcinoma 10.1 LYZ SMUG1
18 lymphatic system cancer 10.1 LYZ SMUG1
19 multiple sclerosis 10.1
20 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
21 myelitis 10.1
22 headache 10.1
23 lymphoma, hodgkin, classic 10.1 HYLS1 SMUG1
24 transverse myelitis 10.1
25 subacute cutaneous lupus erythematosus 10.0 ACE TNF
26 silicosis 10.0 ACE TNF
27 skin sarcoidosis 10.0 ACE TNF
28 granulomatous dermatitis 10.0 ACE TNF
29 amenorrhea 10.0
30 optic nerve disease 10.0
31 glioma 10.0
32 posterior urethral valves 10.0 ACE TNF
33 ischemic heart disease 10.0 ACE TNF
34 pyelonephritis 10.0 ACE TNF
35 cardiac sarcoidosis 10.0 SMUG1 TNF
36 melkersson-rosenthal syndrome 10.0 ACE TNF
37 tuberculous peritonitis 10.0 SMUG1 TNF
38 extrinsic cardiomyopathy 10.0 ACE TNF
39 rheumatic heart disease 10.0 ACE TNF
40 limb ischemia 9.9 ACE TNF
41 carotid stenosis 9.9 ACE TNF
42 adult respiratory distress syndrome 9.9 ACE TNF
43 cogan syndrome 9.9 SMUG1 TNF
44 pulmonary edema 9.9 ACE TNF
45 pleural disease 9.9 SMUG1 TNF
46 microscopic colitis 9.9 LYZ TNF
47 periodic fever, familial, autosomal dominant 9.9 LYZ TNF
48 sleep apnea 9.9 ACE TNF
49 acute salpingitis 9.9 LYZ TNF
50 temporal arteritis 9.9 SMUG1 TNF

Graphical network of the top 20 diseases related to Neurosarcoidosis:



Diseases related to Neurosarcoidosis

Symptoms & Phenotypes for Neurosarcoidosis

MGI Mouse Phenotypes related to Neurosarcoidosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 ACE LYZ SMUG1 TNF

Drugs & Therapeutics for Neurosarcoidosis

Drugs for Neurosarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 4
2 beta-endorphin Phase 4
3 Hormone Antagonists Phase 4
4 Melanocyte-Stimulating Hormones Phase 4
5 Adrenocorticotropic Hormone Phase 4
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
7
Infliximab Approved 170277-31-3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ACTHAR Therapy for Central Nervous System Sarcoidosis Recruiting NCT02920710 Phase 4 Repository Corticotropin Injection
2 Registry for Advanced Sarcodiosis Recruiting NCT03769987
3 Analysis of the Distribution of Regulatory B Cells in Blood of Multiple Sclerosis Patients Recruiting NCT02789670

Search NIH Clinical Center for Neurosarcoidosis

Genetic Tests for Neurosarcoidosis

Anatomical Context for Neurosarcoidosis

MalaCards organs/tissues related to Neurosarcoidosis:

42
Spinal Cord, Brain, Pituitary, Lung, Testes, Hypothalamus, B Cells

Publications for Neurosarcoidosis

Articles related to Neurosarcoidosis:

(show top 50) (show all 541)
# Title Authors Year
1
Magnetic resonance texture analysis utility in differentiating intraparenchymal neurosarcoidosis from primary central nervous system lymphoma: a preliminary analysis. ( 30789057 )
2019
2
Neurosarcoidosis as a Cause of Longitudinally Extensive Myelitis: Neuroimaging Clues for Diagnosis. ( 30692768 )
2019
3
Engorged Medullary Veins in Neurosarcoidosis: A Reflection of Underlying Phlebitis? ( 30679217 )
2019
4
Multiple cerebral infarcts: a rare complication of neurosarcoidosis. ( 30700504 )
2019
5
Infliximab biosimilar for treating neurosarcoidosis: tolerance and efficacy in a retrospective study including switch from the originator and initiation of treatment. ( 30739183 )
2019
6
Cold at the Core: Osborn Waves in Neurosarcoidosis-Induced Central Hypothermia. ( 30766734 )
2019
7
Management of neurosarcoidosis: a clinical challenge. ( 30865007 )
2019
8
Usefulness of 18F-FDG-PET/CT imaging in a patient with neurosarcoidosis. ( 29685313 )
2018
9
Neurosarcoidosis associated with intracerebral haemorrhage: a challenge in diagnosis and management. ( 29363557 )
2018
10
Carotid arteritis causing amaurosis fugax and ischaemic cerebrovascular events in neurosarcoidosis. ( 29653415 )
2018
11
An atypical case of neurosarcoidosis presenting with neovascular glaucoma. ( 29671151 )
2018
12
Cerebrovascular manifestations in neurosarcoidosis: how common are they and does perivascular enhancement matter? ( 29970245 )
2018
13
Not everything is as it seems: neurosarcoidosis presenting as leptomeningitis. ( 29636921 )
2018
14
A case of fatal invasive aspergillosis in a patient with neurosarcoidosis treated with infliximab. ( 30430892 )
2018
15
Neurosarcoidosis Mimics High-Grade Glioma in Dynamic 18F-FET PET Due to LAT Expression. ( 30179915 )
2018
16
Disseminated Histoplasmosis with Miliary Histoplasmosis, Neurohistoplasmosis, and Histoplasma capsulatum Bacteremia in Probable Neurosarcoidosis. ( 30651732 )
2018
17
Neurosarcoidosis Presenting with Obstructive Hydrocephalus Successfully Treated with Endoscopic Third Ventriculostomy. ( 30146586 )
2018
18
Optic Neuropathy and Macular Ischemia Associated with Neurosarcoidosis: A Case Report. ( 30202617 )
2018
19
Neurosarcoidosis Flare with Multifocal Restricted Diffusion: Stroke, Inflammation, or Both? ( 30055999 )
2018
20
Delayed onset of neurosarcoidosis after concurrent ipilimumab/nivolumab therapy. ( 30064495 )
2018
21
Neurosarcoidosis: clinical characteristics, diagnosis, and treatment in eight Chinese patients. ( 30088165 )
2018
22
Clinical diagnostic utility of contrast-enhanced three-dimensional fluid-attenuated inversion recovery for selection of brain biopsy sites in neurosarcoidosis: A case report. ( 30107352 )
2018
23
A Case of Neurosarcoidosis-Induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone Diagnosed with Neuroendoscopy. ( 30158982 )
2018
24
Definition and Consensus Diagnostic Criteria for Neurosarcoidosis: From the Neurosarcoidosis Consortium Consensus Group. ( 30167654 )
2018
25
Co-ocurrence of neurosarcoidosis and intrathecal reactivation of Epstein-Barr virus. ( 30172172 )
2018
26
Neurosarcoidosis following Immune Checkpoint Inhibition. ( 30186134 )
2018
27
Application of the modified Zajicek criteria to diagnose probable spinal cord neurosarcoidosis. ( 30214749 )
2018
28
Engorgement of Deep Medullary Veins in Neurosarcoidosis: A Common-Yet-Underrecognized Cerebrovascular Finding on SWI. ( 30237298 )
2018
29
Novel Use of Rituximab in Treatment of Refractory Neurosarcoidosis in an 11-Year-Old Girl. ( 30247223 )
2018
30
Neurosarcoidosis As a Rare Differential Diagnosis for Single Or Multiple Lesions of the Nervous System. ( 30295542 )
2018
31
FDG-PET abnormalities leading to the diagnosis of an unusual case of probable neurosarcoidosis. ( 30345332 )
2018
32
Neurosarcoidosis Presenting Initially as Idiopathic Vocal Cord Paralysis. ( 30360636 )
2018
33
Neurosarcoidosis. ( 30373709 )
2018
34
Successful therapy with rituximab in three patients with probable neurosarcoidosis. ( 30386436 )
2018
35
Anosmia as the initial presentation of neurosarcoidosis. ( 30478068 )
2018
36
A confusing manifestation: a case report of neurosarcoidosis presenting with confusion. ( 30559946 )
2018
37
Demystifying Neurosarcoidosis and Informing Prognosis. ( 29052731 )
2017
38
Massive Neurosarcoidosis. ( 28824053 )
2017
39
The Protean Neuropsychiatric and Vestibuloauditory Manifestations of Neurosarcoidosis. ( 29166635 )
2017
40
A Rare Case of Neurosarcoidosis Presenting as Severe Hypothermia. ( 28484206 )
2017
41
Neurosarcoidosis Presenting With Recurrent Strokes: A Case Report and Literature Review. ( 28400903 )
2017
42
Neurosarcoidosis: clinical presentations and changing treatment patterns in an Irish Caucasian population. ( 28101825 )
2017
43
Search for biomarkers of neurosarcoidosis by proteomic analysis of cerebrospinal fluid. ( 28751284 )
2017
44
Propionibacterium acnes-associated neurosarcoidosis: A case report with review of the literature. ( 28856748 )
2017
45
(18)F-FDG-PET/CT guiding to diagnosis of neurosarcoidosis. ( 28219645 )
2017
46
(18)F-FDG PET/CT helps in unmasking the great mimicker: A case of neurosarcoidosis with isolated involvement of the spinal cord. ( 28526323 )
2017
47
Characteristics and Long-Term Outcome of Neurosarcoidosis: A Population-Based Study from 1976-2013. ( 28601860 )
2017
48
Extrapyramidal signs in neurosarcoidosis versus multiple sclerosis: Is TNF alpha the link? ( 29054587 )
2017
49
Nodular Leptomeningeal Enhancement in Neurosarcoidosis: Before and After Treatment. ( 28975003 )
2017
50
Neurosarcoidosis and multiple intracerebral hematomas: An unusual clinical presentation. ( 28716245 )
2017

Variations for Neurosarcoidosis

Expression for Neurosarcoidosis

Search GEO for disease gene expression data for Neurosarcoidosis.

Pathways for Neurosarcoidosis

GO Terms for Neurosarcoidosis

Biological processes related to Neurosarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 8.62 LYZ TNF

Sources for Neurosarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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