MCID: NRS005
MIFTS: 36

Neurosarcoidosis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Neurosarcoidosis

MalaCards integrated aliases for Neurosarcoidosis:

Name: Neurosarcoidosis 12 53 15 71
Cerebral Sarcoidosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13403
NCIt 49 C35441
SNOMED-CT 67 111936002
UMLS 71 C0393485 C0398676

Summaries for Neurosarcoidosis

NINDS : 53 Neurosarcoidosis is a manifestation of sarcoidosis in the nervous system.  Sarcoidosis is a chronic inflammatory disorder that typically occurs in adults between 20 and 40 years of age and primarily affects the lungs, but can also impact almost every other organ and system in the body.  Neurosarcoidosis is characterized by inflammation and abnormal cell deposits in any part of the nervous system – the brain, spinal cord, or peripheral nerves.  It most commonly occurs in the cranial and facial nerves, the hypothalamus (a specific area of the brain), and the pituitary gland.  It is estimated to develop in 5 to 15 percent of those individuals who have sarcoidosis.  Weakness of the facial muscles on one side of the face (Bell’s palsy) is a common symptom of neurosarcoidosis.  The optic and auditory nerves can also become involved, causing vision and hearing impairments.  It can cause headache, seizures, memory loss, hallucinations, irritability, agitation, and changes in mood and behavior.  Neurosarcoidosis can appear in an acute, explosive fashion or start as a slow chronic illness.  Because neurosarcoidosis manifests in many different ways, a diagnosis may be difficult and delayed.

MalaCards based summary : Neurosarcoidosis, also known as cerebral sarcoidosis, is related to transverse myelitis and neuritis. An important gene associated with Neurosarcoidosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Hematopoietic cell lineage and Innate Lymphoid Cells Differentiation. The drugs Infliximab and Adrenocorticotropic Hormone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and spinal cord, and related phenotype is immune system.

Disease Ontology : 12 A sarcoidosis that is characterized by involvement of the nervous symptom with cranial nerve palsy, diffuse meningeal disease, acute polyneuropathy, myelitis, or hypothalamic pituitary axis malformation, develops from a type IV hypersensitivity reaction with noncaseating granulomas involving the nervous system.

Wikipedia : 74 Neurosarcoidosis (sometimes shortened to neurosarcoid) refers to a type of sarcoidosis, a condition of... more...

Related Diseases for Neurosarcoidosis

Diseases related to Neurosarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 608)
# Related Disease Score Top Affiliating Genes
1 transverse myelitis 30.6 TNF AQP4
2 neuritis 30.4 TNF MOG AQP4
3 myelitis 30.4 TNF MOG AQP4
4 optic neuritis 30.3 TNF MOG AQP4
5 guillain-barre syndrome 30.2 TNFRSF1B TNF MOG
6 vasculitis 30.2 TNFRSF1B TNF CRP
7 multiple cranial nerve palsy 30.1 CRP ACE
8 meningitis 30.1 TNF CRP AQP4
9 granulomatous angiitis 30.1 CRP ACE
10 chronic meningitis 30.0 MIR642A CRP CD4
11 papilledema 30.0 CRP CD4 ACE
12 internuclear ophthalmoplegia 30.0 MOG AQP4
13 tolosa-hunt syndrome 30.0 CRP ACE
14 arachnoiditis 29.8 CRP CD4 AQP4
15 sarcoidosis 1 29.8 TNFRSF1B TNF CRP CD8A CD4 ACE
16 polyradiculopathy 29.8 TNFRSF1B TNF CRP
17 cranial nerve palsy 29.7 CRP CD4 AQP4 ACE
18 uveoparotid fever 29.6 TNF CD8A ACE
19 mononeuropathy 29.6 TNFRSF1B TNF CRP
20 narcolepsy 29.5 TNFRSF1B TNF MOG AQP4
21 facial paralysis 29.5 CRP CD8A CD4 ACE
22 rubella 29.5 TNFRSF1B TNF MOG
23 choroiditis 29.5 TNFRSF1B TNF CD4 ACE
24 encephalitis 29.5 TNF PNMA2 MOG AQP4
25 mastoiditis 29.5 CRP CD4
26 bacterial meningitis 29.4 TNF CRP AQP4
27 respiratory failure 29.4 TNF CRP CD4 ACE
28 corneal disease 29.4 TNF CD8A CD4
29 stroke, ischemic 29.3 TNF CRP AQP4 ACE
30 skin sarcoidosis 29.3 TNFRSF1B TNF CD8A CD4 ACE
31 sleep apnea 29.3 TNF CRP ACE
32 mononeuritis multiplex 29.2 TNFRSF1B TNF CRP CD4
33 end stage renal disease 29.2 TNF CRP ACE
34 juvenile rheumatoid arthritis 29.1 TNFRSF1B TNF CRP
35 extrapulmonary tuberculosis 29.1 TNF CRP CD4
36 meningoencephalitis 29.1 TNF CRP CD8A CD4
37 iridocyclitis 29.1 TNFRSF1B TNF CRP CD4 ACE
38 histoplasmosis 29.1 TNFRSF1B TNF CD8A CD4
39 migraine with or without aura 1 28.9 TNF CRP AQP4 ACE
40 lung disease 28.9 TNF CRP CD8A ACE
41 autoimmune disease 28.8 TNFRSF1B TNF MOG CRP AQP4
42 multiple sclerosis 28.7 TNFRSF1B TNF MOG CD8A CD4 AQP4
43 demyelinating disease 28.5 TNF MOG CD8A CD4 AQP4
44 optic papillitis 28.3 TNFRSF1B MOG CRP CD4 AQP4 ACE
45 syphilis 28.3 TNF CRP CD8A CD4 ACE
46 panuveitis 28.2 TNFRSF1B TNF CRP CD8A CD4 ACE
47 chickenpox 28.1 TNFRSF1B TNF CRP CD8A CD4
48 central nervous system vasculitis 27.9 TNFRSF1B TNF CRP CD8A CD68 CD4
49 optic nerve disease 27.9 TNF MOG CRP CD8A CD4 AQP4
50 exanthem 27.9 TNFRSF1B TNF CRP CD8A CD4 ACE

Graphical network of the top 20 diseases related to Neurosarcoidosis:



Diseases related to Neurosarcoidosis

Symptoms & Phenotypes for Neurosarcoidosis

MGI Mouse Phenotypes related to Neurosarcoidosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 ACE AQP4 CD4 CD68 CD8A CRP

Drugs & Therapeutics for Neurosarcoidosis

Drugs for Neurosarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved 170277-31-3
2 Adrenocorticotropic Hormone

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Registry for Advanced Sarcoidosis Recruiting NCT03769987
2 Analysis of the Distribution of Regulatory B Cells in Blood of Multiple Sclerosis Patients Recruiting NCT02789670

Search NIH Clinical Center for Neurosarcoidosis

Genetic Tests for Neurosarcoidosis

Anatomical Context for Neurosarcoidosis

MalaCards organs/tissues related to Neurosarcoidosis:

40
Pituitary, Brain, Spinal Cord, Lung, Testes, Hypothalamus, B Cells

Publications for Neurosarcoidosis

Articles related to Neurosarcoidosis:

(show top 50) (show all 1031)
# Title Authors PMID Year
1
Clinical and MRI phenotypes of sarcoidosis-associated myelopathy. 61
32269072 2020
2
Sarcoidosis of the central nervous system: Safety and efficacy of treatment, and experience of biological therapies. 61
32330798 2020
3
Analysis of soluble interleukin-2 receptor as CSF biomarker for neurosarcoidosis. 61
32393650 2020
4
Neurosarcoidosis: Longitudinal experience in a single-center, academic healthcare system. 61
32404428 2020
5
Spinal adhesive arachnoiditis mimicking sarcoid myelitis with nodular dural enhancement: A case report. 61
32535503 2020
6
Relapse of severe neurosarcoidosis with switch from originator infliximab to biosimilar. 61
32393649 2020
7
Distinguishing neurosarcoidosis from multiple sclerosis based on CSF analysis: A retrospective study. 61
32354749 2020
8
Sarcoidosis and the Nervous System. 61
32487903 2020
9
Neurosarcoidosis: Analysis of a series of 20 patients. 61
32564930 2020
10
18F-FDG PET/CT Findings in a Patient With Neurosarcoidosis. 61
32520495 2020
11
Cerebrospinal fluid CD4+/CD8+ ratio in diagnosing neurosarcoidosis. 61
32533774 2020
12
Neurosarcoidosis: clinical manifestations, investigation and treatment. 61
32424017 2020
13
Association Between Tumor Necrosis Factor Inhibitor Exposure and Inflammatory Central Nervous System Events. 61
32421186 2020
14
Whole-Body 18F-FDG PET-CT in the Diagnosis of Neurosarcoidosis. 61
32370838 2020
15
Development of Vitreoretinal Lymphoma in a Patient with Sarcoid Uveitis. 61
31268740 2020
16
The eclipse sign as a radiological presentation of neurosarcoidosis. 61
31679396 2020
17
[A patient with neurosarcoidosis presenting with easy falling and dysphagia]. 61
32307397 2020
18
An Unusual Cause of Stroke: Neurosarcoidosis. 61
31473151 2020
19
Leukocyte profiles in blood and CSF distinguish neurosarcoidosis from multiple sclerosis. 61
32007787 2020
20
Neurosarcoidosis Masquerading as Giant Cell Arteritis With Incidental Meningioma. 61
32441899 2020
21
[Case of isolated neurosarcoidosis requiring differentiation from tuberculous meningitis]. 61
32101846 2020
22
Intracranial vessel wall imaging: applications, interpretation, and pitfalls. 61
32197916 2020
23
Palatal myoclonus secondary to neurosarcoidosis. 61
32185071 2020
24
[Trident sign in spinal cord neurosarcoidosis]. 61
32100280 2020
25
Differentiation between neurosarcoidosis and primary central nervous system vasculitis based on demographic, cerebrospinal and imaging features. 61
31928590 2020
26
Evaluating S100B as a serum biomarker for central neurosarcoidosis. 61
31916532 2020
27
Isolated Bulbar Palsy: A Rare Presentation of Neurosarcoidosis. 61
32206474 2020
28
Hydrocephalus as the presenting symptom of sarcoidosis: A case report and review of literature. 61
32128190 2020
29
Severe visual impairment due to an optic neuropathy and central retinal vein occlusion in a sarcoidosis patient. 61
32002691 2020
30
Viscous Leptomeningeal Pseudotumoural Masses and Multiple Cranial Neuropathy - Severe Presentation of Neurosarcoidosis. 61
32206643 2020
31
Rare Case of Sporadic Malignant Optic Pathway Glioma in 71-Year-Old Woman. 61
31336173 2020
32
Cervical epidural neurosarcoidosis: A case report and literature review. 61
32547820 2020
33
Leptomeningeal Enhancement due to Neurosarcoidosis Mimicking Malignancy. 61
32373180 2020
34
Evaluation of the underlying causes of papilledema in children. 61
31836094 2019
35
Neurosarcoidosis manifesting as panhypopituitarism. 61
31893082 2019
36
Neurosarcoidosis presenting with isolated intracranial mass lesion and communicating hydrocephalus. 61
31882303 2019
37
Neurosarcoidosis presenting with a partial Claude syndrome. 61
31748369 2019
38
Teaching NeuroImages: Corkscrew medullary veins in active neurosarcoidosis. 61
31685713 2019
39
Cerebral microangiopathy in neurosarcoidosis. 61
31642625 2019
40
18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography/Magnetic Resonance Imaging in Neurosarcoidosis. 61
31579251 2019
41
Skull Base Manifestations of Erdheim-Chester Disease: A Case Series and Systematic Review. 61
30828728 2019
42
The cerebrospinal fluid CD4/CD8 ratio and interleukin-6 and -10 levels in neurosarcoidosis: a multicenter, pragmatic, comparative study. 61
31021023 2019
43
Panhypopituitarism from neurosarcoidosis in an adolescent: case report and literature review. 61
31343982 2019
44
Value of Multimodal Imaging Approach to Diagnosis of Neurosarcoidosis. 61
31546573 2019
45
Neurosarcoidosis Presenting as Isolated Bilateral Cerebellopontine Angle Tumors: Case Report and Review of the Literature. 61
31522556 2019
46
Infliximab for relapsing neurosarcoidosis recurring after kidney transplantation: a case report. 61
31486719 2019
47
Advanced sarcoidosis. 61
31365384 2019
48
Neurosarcoidosis and infliximab therapy monitored by 18FDG PET/CT. 61
31225618 2019
49
Novel Use of Rituximab in Treatment of Refractory Neurosarcoidosis in an 11-Year-Old Girl. 61
30247223 2019
50
LncRNA SAMMSON overexpression distinguished glioblastoma patients from patients with diffuse neurosarcoidosis. 61
31283714 2019

Variations for Neurosarcoidosis

Expression for Neurosarcoidosis

Search GEO for disease gene expression data for Neurosarcoidosis.

Pathways for Neurosarcoidosis

Pathways related to Neurosarcoidosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.43 TNF CD8A CD4
2 11.23 TNF CD8A CD4
3 11 TNF CD8A CD4
4 10.99 TNF CD8A CD68 CD4
5 10.65 TNF CRP
6 10.53 TNF CD68

GO Terms for Neurosarcoidosis

Cellular components related to Neurosarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 TNF MOG CD8A CD4 AQP4 ACE

Biological processes related to Neurosarcoidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.96 TNFRSF1B TNF
2 negative regulation of lipid storage GO:0010888 8.62 TNF CRP

Sources for Neurosarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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