MCID: NRS003
MIFTS: 46

Neurosyphilis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Neurosyphilis

MalaCards integrated aliases for Neurosyphilis:

Name: Neurosyphilis 53 54 72

Classifications:



External Ids:

ICD10 33 A52.3
UMLS 72 C0027927

Summaries for Neurosyphilis

NINDS : 54 Neurosyphilis is a disease of the coverings of the brain, the brain itself, or the spinal cord. It can occur in people with syphilis, especially if they are left untreated.  Neurosyphilis is different from syphilis because it affects the nervous system, while syphilis is a sexually transmitted disease with different signs and symptoms.  There are five types of neurosyphilis: asymptomatic neurosyphilis meningeal neurosyphilis meningovascular neurosyphilis general paresis, and tabes dorsalis. Asymptomatic neurosyphilis means that neurosyphilis is present, but the individual reports no symptoms and does not feel sick.  Meningeal syphilis can occur between the first few weeks to the first few years of getting syphilis.  Individuals with meningeal syphilis can have headache, stiff neck, nausea, and vomiting.  Sometimes there can also be loss of vision or hearing. Meningovascular syphilis causes the same symptoms as meningeal syphilis but affected individuals also have strokes.  This form of neurosyphilis can occur within the first few months to several years after infection.  General paresiscan occur between 3 – 30 years after getting syphilis.  People with general paresis can have personality or mood changes.  Tabes dorsalis is characterized by pains in the limbs or abdomen, failure of muscle coordination, and bladder disturbances.  Other signs include vision loss, loss of reflexes and loss of sense of vibration, poor gait, and impaired balance. Tabes dorsalis can occur anywhere from 5 – 50 years after initial syphilis infection.  General paresis and tabes dorsalis are now less common than the other forms of neurosyphilis because of advances made in prevention, screening, and treatment. People with HIV/AIDS are at higher risk of having neurosyphilis.

MalaCards based summary : Neurosyphilis is related to tertiary neurosyphilis and asymptomatic neurosyphilis, and has symptoms including syphilitic chancre An important gene associated with Neurosyphilis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Penicillin G and Procaine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and spinal cord, and related phenotypes are hematopoietic system and immune system

Wikipedia : 75 Neurosyphilis refers to infection of the central nervous system in a patient with syphilis and can occur... more...

Related Diseases for Neurosyphilis

Diseases related to Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 375)
# Related Disease Score Top Affiliating Genes
1 tertiary neurosyphilis 34.5 CXCL13 CXCL10
2 asymptomatic neurosyphilis 34.0 IL17A CXCL8 CXCL13 CXCL10
3 uveitis 30.5 IL17A IL10 CXCL10
4 polyradiculoneuropathy 30.5 IL17A IL10
5 viral encephalitis 30.5 IL10 CXCL8 CXCL10
6 acute transverse myelitis 30.4 IL10 CXCL8
7 panuveitis 30.3 IL17A IL10
8 tuberculous meningitis 30.3 TLR2 CXCL8
9 tick-borne encephalitis 30.3 IL10 CXCL10
10 aseptic meningitis 30.3 IL10 CXCL8
11 transverse myelitis 30.2 IL17A IL10 CXCL8
12 meningitis 30.2 TLR2 IL10 CXCL8
13 aphthous stomatitis 29.8 TLR2 IL10
14 leprosy 3 29.8 TLR2 IL10
15 demyelinating disease 29.8 IL17A IL10 CXCL10
16 arthritis 29.7 IL17A IL10 CXCL8
17 urethritis 29.5 TLR6 TLR1
18 bacterial meningitis 29.5 TLR2 IL10 CXCL8
19 endocarditis 29.5 TLR2 IL10 CXCL8
20 toxic shock syndrome 29.5 TLR2 IL10 CXCL8
21 skin disease 29.5 IL17A IL10 CXCL8 CXCL10
22 malaria 29.4 TLR2 IL17A IL10 CXCL8 CXCL10
23 lyme disease 28.7 TLR6 TLR2 TLR1 IL17A
24 bacterial infectious disease 28.2 TLR2 TLR1 IL17A IL10 CXCL8
25 meningovascular neurosyphilis 12.6
26 parenchymatous neurosyphilis 12.6
27 tabes dorsalis 12.0
28 late congenital syphilis 11.9
29 syphilitic aseptic meningitis 11.6
30 cerebral atrophy 11.5
31 argyll robertson pupil 11.5
32 aids - neurological complications 11.2
33 syphilis 11.1
34 tertiary syphilis 10.9
35 syphilitic myelopathy 10.6
36 immune deficiency disease 10.6
37 encephalitis 10.6
38 transient pseudohypoaldosteronism 10.5
39 dementia 10.5
40 pyelonephritis 10.5 IL10 CXCL8
41 viral meningitis 10.5 CXCL8 CXCL10
42 latent syphilis 10.5
43 apple allergy 10.5 IL10 CXCL10
44 syphilitic meningitis 10.5
45 secondary syphilis 10.5
46 tungiasis 10.5 IL10 CXCL8
47 fungal meningitis 10.5 IL10 CXCL10
48 pouchitis 10.5 IL10 CXCL8
49 scabies 10.5 IL10 CXCL8
50 glaucomatocyclitic crisis 10.5 CXCL8 CXCL10

Comorbidity relations with Neurosyphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Hypertension, Essential
Latent Syphilis Schizophreniform Disorder

Graphical network of the top 20 diseases related to Neurosyphilis:



Diseases related to Neurosyphilis

Symptoms & Phenotypes for Neurosyphilis

UMLS symptoms related to Neurosyphilis:


syphilitic chancre

MGI Mouse Phenotypes related to Neurosyphilis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CXCL10 CXCL13 CXCR5 IL10 IL17A TLR1
2 immune system MP:0005387 9.23 CXCL10 CXCL13 CXCR5 IL10 IL17A TLR1

Drugs & Therapeutics for Neurosyphilis

Drugs for Neurosyphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
2
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
3 penicillins Phase 4
4 Anti-Bacterial Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Penicillin G Procaine Phase 4
7 Penicillin G Benzathine Phase 4
8
Azithromycin Approved Phase 3 83905-01-5 447043 55185
9
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
10 Antiparasitic Agents Phase 3
11 Antimalarials Phase 3
12 Antiprotozoal Agents Phase 3
13
Parathyroid hormone Approved, Investigational Phase 2 9002-64-6
14
Teriparatide Approved, Investigational Phase 2 52232-67-4 16133850
15
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
16 Hormones Phase 2
17 Hormone Antagonists Phase 2
18 Calcium, Dietary Phase 2
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
20 Bone Density Conservation Agents Phase 2
21
Ceftriaxone Approved 73384-59-5 5479530 5361919

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage in HIV Co-Infected Patients Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 A Phase III Equivalence Trial of Azithromycin vs. Benzathine Penicillin for the Treatment of Early Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
3 Rapid Diagnostic Tests in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases in Patients With Neurological Disorders in Rural Hospitals of Bandundu,Democratic Republic of Congo Completed NCT01589289 Phase 3
4 To Study the Efficacy of Teriparatide in Improving Remodeling of Foot Bones in Chronic Charcot Neuroarthropathy in Patients With Diabetes Mellitus. Unknown status NCT02023411 Phase 2 Teriparatide
5 A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals Completed NCT00000648 Penicillin G potassium;Ceftriaxone sodium
6 Xijing HOSPITAL, Fourth Military Medical University, China Completed NCT00921648
7 Danish Study Group of Infections of the Brain: A Nationwide Prospective Observational Cohort Study of All Central Nervous System Infections in Adults at Departments of Infectious Diseases in Denmark Recruiting NCT03418441

Search NIH Clinical Center for Neurosyphilis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Probenecid

Genetic Tests for Neurosyphilis

Anatomical Context for Neurosyphilis

MalaCards organs/tissues related to Neurosyphilis:

41
Testes, Brain, Spinal Cord, Bone, Skin, Eye, Liver

Publications for Neurosyphilis

Articles related to Neurosyphilis:

(show top 50) (show all 2102)
# Title Authors PMID Year
1
Novel Biochemical Insights in the Cerebrospinal Fluid of Patients with Neurosyphilis Based on a Metabonomics Study. 38
31321646 2019
2
Syphilitic hepatitis and neurosyphilis: an observational study of Danish HIV-infected individuals during a 13-year period. 38
30923165 2019
3
Neurosyphilis prevalence at a Portuguese stroke unit care. 38
30343380 2019
4
Neurosyphilis in the modern era: Literature review and case series. 38
31427238 2019
5
Diagnosis of Neurosyphilis in a Collaborative Care Setting. 38
31381846 2019
6
Memantine Rescues Neurosyphilis-Related Schizophrenic-like Features and Cognitive Deficit. 38
31135390 2019
7
Creutzfeldt-Jakob Disease Mimicking Neurosyphilis: A Complex Presentation, Histopathological Findings, and Special Precautions for Autopsy. 38
31306170 2019
8
Neurosyphilis is more common in malignant syphilis: A case series and review of the literature. 38
31142223 2019
9
[Clinical and socio-demographic profile of neurosyphilis: a retrospective study in a reference centre in Colombia]. 38
31287148 2019
10
Acute Syphilitic Posterior Placoid Chorioretinitis: Multimodal Imaging and Electrophysiologic Findings Before and After Treatment. 38
31356370 2019
11
[Ocular syphilis, a re-emergent pathology: Series of 12 patients in one Hospital, 2017]. 38
31301942 2019
12
Concurrent aquaporin-4-positive NMOSD and neurosyphilis: A case report. 38
31272070 2019
13
Coexistence of Papillitis and Posterior Placoid Chorioretinopathy as the Presenting Symptoms of Syphilis-Human Immunodeficiency Virus Coinfection. 38
31312245 2019
14
Retrospective review of tertiary and neurosyphilis cases in Alberta, 1973-2017. 38
31230001 2019
15
Exosomal microRNA profiles from serum and cerebrospinal fluid in neurosyphilis. 38
30926713 2019
16
Clinical features of syphilitic myelitis with longitudinally extensive myelopathy on spinal magnetic resonance imaging. 38
31236392 2019
17
Neurosyphilis Presenting as Mania and Psychosis After Incidental Treatment With Cephalexin: A Case Report and Literature Review of Jarisch-Herxheimer Reactions. 38
31331661 2019
18
Pruritic Plaque on the Arm After Treatment for Neurosyphilis. 38
30576631 2019
19
Antibiotic therapy for adults with neurosyphilis. 38
31132142 2019
20
Lesson of the month 1: Neurosyphilis mimicking viral encephalitis and ischaemic stroke. 38
31092522 2019
21
Neurosyphilis: Concordance between cerebrospinal fluid analysis and subsequent antibiotic strategy for patients undergoing evaluation of a diagnosis of neurosyphilis. 38
30853444 2019
22
A Case Report of Neurosyphilis Limbic Encephalitis With Reversible Geschwind Syndrome and Mood Disorder. 38
31083037 2019
23
Neurosyphilis during Acute HIV Infection: A CNS Immunologic and Virologic Characterization. 38
31180994 2019
24
Changes of T lymphocyte subsets in patients with HIV-negative symptomatic neurosyphilis. 38
30862559 2019
25
Early neurosyphilis presenting with multiple cranial nerve palsies: A case report of management by combined penicillin-corticosteroid treatment. 38
30538059 2019
26
Retinal and choroidal abnormalities identified by multispectral imaging in patients with uveitis: Three case reports. 38
31096491 2019
27
Diagnostic and Therapeutic Knowledge and Practices in the Management of Congenital Syphilis by Pediatricians in Public Maternity Hospitals in Brazil. 38
28735562 2019
28
[Early treatment of neurosyphilis is crucial]. 38
30931888 2019
29
Spinal Cord Syphilitic Gumma Presenting with Brown-Séquard Syndrome: A Case Report and Literature Review. 38
31028074 2019
30
Multiple cerebral syphilitic gummas mimicking brain tumor in a non-HIV-infected patient: A case report. 38
30249387 2019
31
Analysis of EEG Lemple-Ziv complexity and correlative aspects before and after treatment of anti-syphilis therapy for neurosyphilis. 38
30912484 2019
32
Schizophrenia-like psychosis as the presenting feature of neurosyphilis in a non-human immunodeficiency virus-infected Indian man: A reminder of a forgotten complication! 38
30992619 2019
33
Neurosyphilis presenting as rapidly progressive psychosis & dementia - A forgotten entity. 38
30785032 2019
34
Atypical development of neurosyphilis mimicking limbic encephalitis. 38
30253732 2019
35
Neurosyphilis presenting as cranial nerve palsy, an entity which is easy to miss. 38
30796075 2019
36
A comparison of nontreponemal tests in cerebrospinal fluid for neurosyphilis diagnosis: equivalent detection of specific antibodies. 38
30810592 2019
37
Rapid progression to gummatous tertiary syphilis in a patient with HIV. 38
29882582 2019
38
A Rare Case of Neurosyphilis with Ocular Involvement in a Patient with HIV Infection and New Onset Syphilis. 38
31011497 2019
39
Ischemic stroke and infectious diseases in low-income and middle-income countries. 38
30516643 2019
40
Metabolite Profiles of the Cerebrospinal Fluid in Neurosyphilis Patients Determined by Untargeted Metabolomics Analysis. 38
30863278 2019
41
[Interleukins - 23, -12p40 as markers of neural tissue damage in neurosyphilis.] 38
30917250 2019
42
Predictors of unfavorable outcome in neurosyphilis: Multicenter ID-IRI Study. 38
30368740 2019
43
Clinical and Laboratory Characteristics of Symptomatic and Asymptomatic Neurosyphilis in HIV-Negative Patients: A Retrospective Study of 264 Cases. 38
31198783 2019
44
Risk of neurosyphilis in HIV-infected persons with syphilis lacking signs or symptoms of central nervous system infection. 38
30402918 2019
45
A Stroke in the Young with Surprising Recovery. 38
31157179 2019
46
Combined Intravitreal and Systemic Antibiotic Therapy in a Patient with Syphilitic Uveitis. 38
29053397 2019
47
HIV-associated cavernous sinus disease. 38
31061723 2019
48
Controlled Human Malaria Infection (CHMI) Studies: Over 100 Years of Experience with Parasite Injections. 38
31267496 2019
49
Gummatous penile syphilis. 38
31406680 2019
50
Current ophthalmology practice patterns for syphilitic uveitis. 38
31021330 2019

Variations for Neurosyphilis

Expression for Neurosyphilis

Search GEO for disease gene expression data for Neurosyphilis.

Pathways for Neurosyphilis

Pathways related to Neurosyphilis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 TLR6 TLR2 TLR1 IL17A IL10 CXCL8
2
Show member pathways
13.61 IL17A IL10 CXCR5 CXCL8 CXCL13 CXCL10
3
Show member pathways
13.45 IL17A IL10 CXCR5 CXCL8 CXCL13 CXCL10
4
Show member pathways
13.1 IL17A IL10 CXCR5 CXCL8 CXCL13 CXCL10
5
Show member pathways
12.84 TLR6 TLR2 TLR1 IL10 CXCL8 CXCL10
6
Show member pathways
12.76 TLR6 TLR2 TLR1 IL17A IL10 CXCR5
7
Show member pathways
12.71 IL17A IL10 CXCR5 CXCL8 CXCL13
8
Show member pathways
12.69 CXCR5 CXCL8 CXCL13 CXCL10
9
Show member pathways
12.27 TLR6 TLR2 TLR1
10
Show member pathways
12.2 TLR6 TLR2 TLR1
11
Show member pathways
12.18 TLR2 IL17A CXCL8 CXCL10
12
Show member pathways
12.09 CXCR5 CXCL8 CXCL13 CXCL10
13
Show member pathways
12.07 TLR6 TLR2 TLR1 CXCL8
14 12.03 TLR6 TLR2 TLR1 IL10
15 12.02 TLR6 TLR2 TLR1
16
Show member pathways
11.98 TLR6 TLR2 TLR1 CXCL8 CXCL13 CXCL10
17
Show member pathways
11.89 TLR6 TLR2 TLR1
18
Show member pathways
11.88 TLR6 TLR2 TLR1
19
Show member pathways
11.87 TLR6 TLR2 TLR1 CXCL8 CXCL10
20 11.84 IL17A IL10 CXCL8
21 11.78 TLR2 IL10 CXCL8
22 11.74 TLR2 IL17A CXCL8
23 11.69 TLR6 TLR2 TLR1
24 11.68 TLR6 TLR2 TLR1 IL17A IL10 CXCR5
25
Show member pathways
11.67 TLR6 TLR2 TLR1 IL17A IL10
26 11.66 IL17A IL10 CXCR5
27 11.52 IL17A IL10 CXCL13 CXCL10
28 11.4 TLR2 IL10 CXCL8
29 11.39 IL10 CXCL8 CXCL10
30 11.18 CXCL13 CXCL10
31 11.04 TLR2 TLR1
32 10.95 IL17A IL10 CXCL8 CXCL13 CXCL10
33 10.81 IL17A IL10 CXCL8 CXCL13 CXCL10

GO Terms for Neurosyphilis

Cellular components related to Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.33 TLR6 TLR2 TLR1
2 phagocytic vesicle membrane GO:0030670 9.13 TLR6 TLR2 TLR1
3 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR2 TLR1

Biological processes related to Neurosyphilis according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.91 IL17A IL10 CXCL8 CXCL10
2 defense response to bacterium GO:0042742 9.83 TLR6 IL10 CXCL13
3 cell-cell signaling GO:0007267 9.83 IL17A CXCL13 CXCL10
4 response to lipopolysaccharide GO:0032496 9.83 TLR2 IL10 CXCL10
5 cell chemotaxis GO:0060326 9.8 CXCR5 CXCL13 CXCL10
6 cellular response to lipopolysaccharide GO:0071222 9.8 IL10 CXCL8 CXCL13 CXCL10
7 neutrophil chemotaxis GO:0030593 9.79 CXCL8 CXCL13 CXCL10
8 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.77 CXCL8 CXCL13 CXCL10
9 chemotaxis GO:0006935 9.76 CXCR5 CXCL8 CXCL13 CXCL10
10 defense response GO:0006952 9.73 TLR1 CXCL8 CXCL13 CXCL10
11 toll-like receptor signaling pathway GO:0002224 9.72 TLR6 TLR2 TLR1
12 microglial cell activation GO:0001774 9.65 TLR6 TLR2
13 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.65 TLR6 TLR2 TLR1
14 positive regulation of macrophage activation GO:0043032 9.64 TLR6 IL10
15 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.64 TLR6 IL17A
16 positive regulation of interleukin-8 secretion GO:2000484 9.63 TLR2 TLR1
17 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.61 TLR6 TLR1
18 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.59 TLR6 TLR2
19 cellular response to diacyl bacterial lipopeptide GO:0071726 9.58 TLR6 TLR2
20 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.58 TLR2 TLR1
21 regulation of cytokine secretion GO:0050707 9.58 TLR6 TLR2 TLR1
22 nitric oxide metabolic process GO:0046209 9.57 TLR6 TLR2
23 cellular response to triacyl bacterial lipopeptide GO:0071727 9.56 TLR2 TLR1
24 chemokine-mediated signaling pathway GO:0070098 9.56 CXCR5 CXCL8 CXCL13 CXCL10
25 inflammatory response GO:0006954 9.56 TLR6 TLR2 TLR1 IL17A IL10 CXCL8
26 leukocyte chemotaxis GO:0030595 9.55 IL10 CXCR5 CXCL8 CXCL13 CXCL10
27 response to bacterial lipoprotein GO:0032493 9.54 TLR6 TLR2
28 response to molecule of bacterial origin GO:0002237 9.54 TLR2 IL10 CXCL8
29 detection of triacyl bacterial lipopeptide GO:0042495 9.52 TLR2 TLR1
30 detection of diacyl bacterial lipopeptide GO:0042496 9.51 TLR6 TLR2
31 cell activation GO:0001775 9.5 TLR6 TLR2 TLR1
32 immune response GO:0006955 9.28 TLR6 TLR2 TLR1 IL17A IL10 CXCR5
33 signal transduction GO:0007165 10.1 TLR6 TLR2 TLR1 CXCR5 CXCL8 CXCL10

Molecular functions related to Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.67 TLR6 TLR2 TLR1 CXCL13
2 signaling receptor activity GO:0038023 9.58 TLR6 TLR2 TLR1
3 chemokine activity GO:0008009 9.43 CXCL8 CXCL13 CXCL10
4 CXCR3 chemokine receptor binding GO:0048248 9.32 CXCL13 CXCL10
5 Toll-like receptor 2 binding GO:0035663 9.16 TLR6 TLR1
6 lipopeptide binding GO:0071723 9.13 TLR6 TLR2 TLR1
7 cytokine activity GO:0005125 9.02 IL17A IL10 CXCL8 CXCL13 CXCL10

Sources for Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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