MCID: NRS003
MIFTS: 48

Neurosyphilis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Neurosyphilis

MalaCards integrated aliases for Neurosyphilis:

Name: Neurosyphilis 53 54 73

Classifications:



External Ids:

ICD10 33 A52.3
UMLS 73 C0027927

Summaries for Neurosyphilis

NINDS : 54 Neurosyphilis is a disease of the coverings of the brain, the brain itself, or the spinal cord. It can occur in people with syphilis, especially if they are left untreated.  Neurosyphilis is different from syphilis because it affects the nervous system, while syphilis is a sexually transmitted disease with different signs and symptoms.  There are five types of neurosyphilis: asymptomatic neurosyphilis meningeal neurosyphilis meningovascular neurosyphilis general paresis, and tabes dorsalis. Asymptomatic neurosyphilis means that neurosyphilis is present, but the individual reports no symptoms and does not feel sick.  Meningeal syphilis can occur between the first few weeks to the first few years of getting syphilis.  Individuals with meningeal syphilis can have headache, stiff neck, nausea, and vomiting.  Sometimes there can also be loss of vision or hearing. Meningovascular syphilis causes the same symptoms as meningeal syphilis but affected individuals also have strokes.  This form of neurosyphilis can occur within the first few months to several years after infection.  General paresiscan occur between 3 – 30 years after getting syphilis.  People with general paresis can have personality or mood changes.  Tabes dorsalis is characterized by pains in the limbs or abdomen, failure of muscle coordination, and bladder disturbances.  Other signs include vision loss, loss of reflexes and loss of sense of vibration, poor gait, and impaired balance. Tabes dorsalis can occur anywhere from 5 – 50 years after initial syphilis infection.  General paresis and tabes dorsalis are now less common than the other forms of neurosyphilis because of advances made in prevention, screening, and treatment. People with HIV/AIDS are at higher risk of having neurosyphilis.

MalaCards based summary : Neurosyphilis is related to asymptomatic neurosyphilis and tertiary neurosyphilis, and has symptoms including syphilitic chancre An important gene associated with Neurosyphilis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Procaine and Penicillin G have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 Neurosyphilis refers to infection of the central nervous system in a patient with syphilis and can occur... more...

Related Diseases for Neurosyphilis

Diseases related to Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 33.9 CXCL10 CXCL13 CXCL8 IL17A
2 tertiary neurosyphilis 33.8 CXCL10 CXCL13
3 viral infectious disease 30.5 CXCL10 CXCL8 IL10
4 malaria 30.0 CXCL10 CXCL8 IL10 IL17A TLR2
5 transverse myelitis 29.9 CXCL8 IL10 IL17A
6 viral encephalitis 29.8 CXCL10 IL10
7 meningitis 29.8 CXCL8 IL10 TLR2
8 panuveitis 29.8 IL10 IL17A
9 polyradiculoneuropathy 29.8 IL10 IL17A
10 arthritis 29.6 CXCL8 IL10 IL17A
11 tuberculous meningitis 29.6 CXCL8 TLR2
12 multiple sclerosis 29.5 CXCL10 CXCL13 IL10 IL17A
13 pneumonia 29.4 CXCL8 IL10 TLR2
14 psoriasis 29.4 CXCL10 CXCL8 IL10 IL17A
15 lyme disease 29.0 IL17A TLR1 TLR2 TLR6
16 meningovascular neurosyphilis 12.4
17 parenchymatous neurosyphilis 12.4
18 tabes dorsalis 11.8
19 late congenital syphilis 11.5
20 argyll robertson pupil 11.4
21 syphilitic aseptic meningitis 11.0
22 aids - neurological complications 11.0
23 cerebral atrophy 11.0
24 syphilis 10.6
25 tertiary syphilis 10.6
26 dementia 10.4
27 encephalitis 10.4
28 status epilepticus 10.3
29 human immunodeficiency virus infectious disease 10.3
30 pyelonephritis 10.2 CXCL8 IL10
31 viral meningitis 10.2 CXCL10 CXCL8
32 tungiasis 10.2 CXCL8 IL10
33 apple allergy 10.2 CXCL10 IL10
34 acute transverse myelitis 10.2 CXCL8 IL10
35 pouchitis 10.2 CXCL8 IL10
36 fungal meningitis 10.2 CXCL10 IL10
37 vulvovaginitis 10.2 CXCL8 IL10
38 scabies 10.2 CXCL8 IL10
39 necatoriasis 10.2 CXCL8 IL10
40 peanut allergy 10.2 CXCL10 IL10
41 trichuriasis 10.2 CXCL8 IL10
42 glaucomatocyclitic crisis 10.2 CXCL10 CXCL8
43 funisitis 10.2 CXCL8 IL10
44 clonorchiasis 10.2 CXCL8 IL10
45 retinitis pigmentosa 44 10.2 CXCL8 IL10
46 spotted fever 10.2 CXCL10 IL10
47 acute generalized exanthematous pustulosis 10.2 CXCL8 IL17A
48 mycetoma 10.2 CXCL8 IL10
49 palladium allergic contact dermatitis 10.2 IL10 IL17A
50 diversion colitis 10.2 CXCL13 CXCR5

Comorbidity relations with Neurosyphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Hypertension, Essential
Latent Syphilis Schizophreniform Disorder

Graphical network of the top 20 diseases related to Neurosyphilis:



Diseases related to Neurosyphilis

Symptoms & Phenotypes for Neurosyphilis

UMLS symptoms related to Neurosyphilis:


syphilitic chancre

MGI Mouse Phenotypes related to Neurosyphilis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CXCL10 CXCL13 CXCR5 IL10 IL17A TLR1
2 immune system MP:0005387 9.23 CXCL10 CXCL13 CXCR5 IL10 IL17A TLR1

Drugs & Therapeutics for Neurosyphilis

Drugs for Neurosyphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaine Approved, Investigational, Vet_approved Phase 4,Not Applicable 59-46-1 4914
2
Penicillin G Approved, Vet_approved Phase 4,Not Applicable 61-33-6 5904
3 Penicillin G Benzathine Phase 4,Not Applicable
4 penicillins Phase 4,Not Applicable
5 Anti-Bacterial Agents Phase 4,Not Applicable
6 Anti-Infective Agents Phase 4,Not Applicable
7 Penicillin G Procaine Phase 4,Not Applicable
8
Ceftriaxone Approved Not Applicable 73384-59-5 5479530 5361919

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
3 A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals Completed NCT00000648 Not Applicable Penicillin G potassium;Ceftriaxone sodium
4 Clinical Findings in General Paresis Completed NCT00921648
5 Central Nervous System Infections in Denmark Recruiting NCT03418441
6 Biomarker for Duchenne Disease Recruiting NCT02994030

Search NIH Clinical Center for Neurosyphilis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Neurosyphilis

Anatomical Context for Neurosyphilis

MalaCards organs/tissues related to Neurosyphilis:

41
Brain, Testes, Spinal Cord, Bone, Skin, B Cells, T Cells

Publications for Neurosyphilis

Articles related to Neurosyphilis:

(show top 50) (show all 965)
# Title Authors Year
1
Study on influence factors related to antibiotic treatment of neurosyphilis. ( 29877685 )
2018
2
Teaching NeuroImages: Gummatous neurosyphilis: An atypical presentation in a patient with HIV. ( 29507143 )
2018
3
Neurosyphilis with Bilateral Optic Perineuritis in an Immunocompetent Patient. ( 29566376 )
2018
4
Neurosyphilis as a Cause of Transverse Myelitis in a Teenage Girl. ( 29602529 )
2018
5
The performance of rapid plasma reagin (RPR) titer in HIV-negative general paresis after neurosyphilis therapy. ( 29606102 )
2018
6
Different Faces of Neurosyphilis. ( 29624563 )
2018
7
Diplopia: An Overlooked Feature in Patients With Neurosyphilis. Report of 2 Cases and Literature Review. ( 29329180 )
2018
8
Cerebellar alterations: An infrequent presentation of neurosyphilis. ( 29891337 )
2018
9
Ischemic Stroke in an HIV Positive Patient: An Initial Presentation of Neurosyphilis. ( 29666731 )
2018
10
Neurosyphilis: Knowledge Gaps and Controversies. ( 29420441 )
2018
11
Neurosyphilis: mighty imitator forays with benign presentation and unique neuroimaging findings. ( 29706150 )
2018
12
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series. ( 29972419 )
2018
13
How Well Do Neurologic Symptoms Identify Individuals With Neurosyphilis? ( 29020214 )
2018
14
Electroclinical and radiological observation of dysfunctional zones in a patient with neurosyphilis. ( 29620006 )
2018
15
Neurosyphilis manifesting as trigeminal nerve dysfunction. ( 29972581 )
2018
16
Psychotic mania as the solitary manifestation of neurosyphilis. ( 29928290 )
2018
17
The clinical and laboratory features of neurosyphilis in HIV-infected patients: A retrospective study in 92 patients. ( 29489672 )
2018
18
Management of neurosyphilis: time for a new approach? ( 29415349 )
2018
19
Dilated tonic pupils with tabes dorsalis in neurosyphilis as first manifestation of HIV/AIDS: a video report. ( 29545440 )
2018
20
Neurosyphilis in patients with HIV. ( 29478035 )
2018
21
Neurosyphilis Presenting with Anxiety: A Case Report. ( 30254809 )
2018
22
Newly diagnosed AIDS with neurosyphilis, Kaposi sarcoma, pancytopenia, oropharyngeal candidiasis, and pseudomonal pneumonia: We shouldn't be seeing this anymore. ( 30101071 )
2018
23
Comparison of Clinical and Laboratory Characteristics of General Paresis and Non-Neurosyphilis Dementia. ( 30343296 )
2018
24
Atypical development of neurosyphilis mimicking limbic encephalitis. ( 30253732 )
2018
25
Thomas Mann's depiction of neurosyphilis and other diseases. ( 28471291 )
2018
26
A case of very early neurosyphilis presented as schizophrenia-like psychosis. ( 29453149 )
2018
27
Postmortem Histopathologic Analysis of Neurosyphilis: A Report of 3 Cases With Clinicopathologic Correlations. ( 29546365 )
2018
28
Diagnostic performance of PCR assays for the diagnosis of neurosyphilis: a systematic review. ( 30061192 )
2018
29
Neurosyphilis: The shape of a rising threat. ( 30081207 )
2018
30
Charcot osteoarthropathy of the knee secondary to neurosyphilis: a rare condition managed by a challenging arthrodesis. ( 30131415 )
2018
31
Medial medullary stroke due to neurosyphilis in a newly diagnosed HIV-positive man. ( 30133989 )
2018
32
Neurosyphilis: A Simulation Case for Emergency Medicine Residents. ( 30237945 )
2018
33
Neuroborreliosis and Neurosyphilis. ( 30273247 )
2018
34
Neurosyphilis prevalence at a Portuguese stroke unit care. ( 30343380 )
2018
35
Neurosyphilis concurrently involving eye and ear. ( 30344157 )
2018
36
Predictors of unfavorable outcome in neurosyphilis: Multicenter ID-IRI Study. ( 30368740 )
2018
37
Risk of neurosyphilis in HIV-infected persons with syphilis lacking signs or symptoms of central nervous system infection. ( 30402918 )
2018
38
Lack of antiretroviral therapy is associated with higher risk of neurosyphilis among HIV-infected patients who remain serofast after therapy for early syphilis. ( 30407349 )
2018
39
Neurosyphilis: a masked evildoer. ( 30530406 )
2018
40
Early neurosyphilis presenting with multiple cranial nerve palsies: A case report of management by combined penicillin-corticosteroid treatment. ( 30538059 )
2018
41
Neurosyphilis, an emerging problem? ( 27823793 )
2017
42
LncRNA Expression in CD4+ T Cells in Neurosyphilis Patients. ( 29167762 )
2017
43
Reversible Dementia with Middle Cerebellar Peduncle Hyperintensity: 1-Year Follow-Up of HIV-Negative Neurosyphilis. ( 28831790 )
2017
44
Concomitant neurosyphilis and herpes simplex encephalitis in an immunocompetent patient: a case report. ( 28914386 )
2017
45
Erratum: A case of neurosyphilis presenting with limbic encephalitis. ( 28458373 )
2017
46
CXCL13 and TH1/Th2 cytokines in the serum and cerebrospinal fluid of neurosyphilis patients. ( 29381995 )
2017
47
Neuropsychiatric Features of Neurosyphilis: Frequency, Relationship with the Severity of Cognitive Impairment and Comparison with Alzheimer Disease. ( 28538242 )
2017
48
Role of MRI in early detection of stroke secondary to neurosyphilis in an elderly patient coinfected with HIV. ( 29185547 )
2017
49
Neurosyphilis: An underdiagnosed entity. ( 28738261 )
2017
50
Screening for asymptomatic neurosyphilis in HIV patients after treatment of early syphilis: an observational study. ( 28196838 )
2017

Variations for Neurosyphilis

Expression for Neurosyphilis

Search GEO for disease gene expression data for Neurosyphilis.

Pathways for Neurosyphilis

Pathways related to Neurosyphilis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 CXCL10 CXCL8 IL10 IL17A TLR1 TLR2
2
Show member pathways
13.61 CXCL10 CXCL13 CXCL8 CXCR5 IL10 IL17A
3
Show member pathways
13.45 CXCL10 CXCL13 CXCL8 CXCR5 IL10 IL17A
4
Show member pathways
13.1 CXCL10 CXCL13 CXCL8 CXCR5 IL10 IL17A
5
Show member pathways
12.76 CXCL10 CXCL8 IL10 TLR1 TLR2 TLR6
6
Show member pathways
12.76 CXCL10 CXCL13 CXCL8 CXCR5 IL10 IL17A
7
Show member pathways
12.7 CXCL13 CXCL8 CXCR5 IL10 IL17A
8
Show member pathways
12.69 CXCL10 CXCL13 CXCL8 CXCR5
9
Show member pathways
12.27 TLR1 TLR2 TLR6
10
Show member pathways
12.2 TLR1 TLR2 TLR6
11
Show member pathways
12.18 CXCL10 CXCL8 IL17A TLR2
12
Show member pathways
12.07 CXCL8 TLR1 TLR2 TLR6
13 12.03 IL10 TLR1 TLR2 TLR6
14 12.02 TLR1 TLR2 TLR6
15
Show member pathways
11.98 CXCL10 CXCL13 CXCL8 TLR1 TLR2 TLR6
16
Show member pathways
11.89 TLR1 TLR2 TLR6
17
Show member pathways
11.88 TLR1 TLR2 TLR6
18
Show member pathways
11.87 CXCL10 CXCL8 TLR1 TLR2 TLR6
19 11.84 CXCL8 IL10 IL17A
20
Show member pathways
11.82 CXCL10 CXCL13 CXCL8 CXCR5
21 11.76 CXCL8 IL10 TLR2
22 11.72 CXCL8 IL17A TLR2
23 11.69 TLR1 TLR2 TLR6
24 11.68 CXCL10 CXCR5 IL10 IL17A TLR1 TLR2
25
Show member pathways
11.67 IL10 IL17A TLR1 TLR2 TLR6
26 11.66 CXCR5 IL10 IL17A
27 11.52 CXCL10 CXCL13 IL10 IL17A
28 11.4 CXCL10 CXCL8 IL10
29 11.39 CXCL8 IL10 TLR2
30 11.18 CXCL10 CXCL13
31 11.04 TLR1 TLR2
32 10.95 CXCL10 CXCL13 CXCL8 IL10 IL17A
33 10.81 CXCL10 CXCL13 CXCL8 IL10 IL17A

GO Terms for Neurosyphilis

Cellular components related to Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.33 TLR1 TLR2 TLR6
2 phagocytic vesicle membrane GO:0030670 9.13 TLR1 TLR2 TLR6
3 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Neurosyphilis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.91 CXCL10 CXCL8 IL10 IL17A
2 regulation of signaling receptor activity GO:0010469 9.89 CXCL10 CXCL13 CXCL8 IL10 IL17A
3 defense response to bacterium GO:0042742 9.84 CXCL13 IL10 TLR6
4 cell-cell signaling GO:0007267 9.83 CXCL10 CXCL13 IL17A
5 response to lipopolysaccharide GO:0032496 9.83 CXCL10 IL10 TLR2
6 cellular response to lipopolysaccharide GO:0071222 9.81 CXCL10 CXCL13 CXCL8 IL10
7 cell chemotaxis GO:0060326 9.8 CXCL10 CXCL13 CXCR5
8 neutrophil chemotaxis GO:0030593 9.8 CXCL10 CXCL13 CXCL8
9 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.78 CXCL10 CXCL13 CXCL8
10 chemotaxis GO:0006935 9.76 CXCL10 CXCL13 CXCL8 CXCR5
11 toll-like receptor signaling pathway GO:0002224 9.73 TLR1 TLR2 TLR6
12 defense response GO:0006952 9.73 CXCL10 CXCL13 CXCL8 TLR1
13 microglial cell activation GO:0001774 9.65 TLR2 TLR6
14 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.65 IL17A TLR6
15 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.65 TLR1 TLR2 TLR6
16 positive regulation of macrophage activation GO:0043032 9.64 IL10 TLR6
17 positive regulation of interleukin-8 secretion GO:2000484 9.64 TLR1 TLR2
18 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.62 TLR1 TLR6
19 cellular response to diacyl bacterial lipopeptide GO:0071726 9.6 TLR2 TLR6
20 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.59 TLR2 TLR6
21 cellular response to triacyl bacterial lipopeptide GO:0071727 9.58 TLR1 TLR2
22 nitric oxide metabolic process GO:0046209 9.58 TLR2 TLR6
23 regulation of cytokine secretion GO:0050707 9.58 TLR1 TLR2 TLR6
24 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.57 TLR1 TLR2
25 chemokine-mediated signaling pathway GO:0070098 9.56 CXCL10 CXCL13 CXCL8 CXCR5
26 inflammatory response GO:0006954 9.56 CXCL10 CXCL13 CXCL8 IL10 IL17A TLR1
27 detection of diacyl bacterial lipopeptide GO:0042496 9.55 TLR2 TLR6
28 leukocyte chemotaxis GO:0030595 9.55 CXCL10 CXCL13 CXCL8 CXCR5 IL10
29 detection of triacyl bacterial lipopeptide GO:0042495 9.54 TLR1 TLR2
30 cell activation GO:0001775 9.54 TLR1 TLR2 TLR6
31 response to bacterial lipoprotein GO:0032493 9.52 TLR2 TLR6
32 response to molecule of bacterial origin GO:0002237 9.5 CXCL8 IL10 TLR2
33 immune response GO:0006955 9.28 CXCL10 CXCL13 CXCL8 CXCR5 IL10 IL17A
34 signal transduction GO:0007165 10.11 CXCL10 CXCL8 CXCR5 TLR1 TLR2 TLR6

Molecular functions related to Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.67 CXCL13 TLR1 TLR2 TLR6
2 signaling receptor activity GO:0038023 9.58 TLR1 TLR2 TLR6
3 chemokine activity GO:0008009 9.43 CXCL10 CXCL13 CXCL8
4 CXCR3 chemokine receptor binding GO:0048248 9.32 CXCL10 CXCL13
5 Toll-like receptor 2 binding GO:0035663 9.16 TLR1 TLR6
6 lipopeptide binding GO:0071723 9.13 TLR1 TLR2 TLR6
7 cytokine activity GO:0005125 9.02 CXCL10 CXCL13 CXCL8 IL10 IL17A

Sources for Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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