MCID: NRS003
MIFTS: 46

Neurosyphilis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Neurosyphilis

MalaCards integrated aliases for Neurosyphilis:

Name: Neurosyphilis 54 55 74

Classifications:



External Ids:

ICD10 34 A52.3
UMLS 74 C0027927

Summaries for Neurosyphilis

NINDS : 55 Neurosyphilis is a disease of the coverings of the brain, the brain itself, or the spinal cord. It can occur in people with syphilis, especially if they are left untreated.  Neurosyphilis is different from syphilis because it affects the nervous system, while syphilis is a sexually transmitted disease with different signs and symptoms.  There are five types of neurosyphilis: asymptomatic neurosyphilis meningeal neurosyphilis meningovascular neurosyphilis general paresis, and tabes dorsalis. Asymptomatic neurosyphilis means that neurosyphilis is present, but the individual reports no symptoms and does not feel sick.  Meningeal syphilis can occur between the first few weeks to the first few years of getting syphilis.  Individuals with meningeal syphilis can have headache, stiff neck, nausea, and vomiting.  Sometimes there can also be loss of vision or hearing. Meningovascular syphilis causes the same symptoms as meningeal syphilis but affected individuals also have strokes.  This form of neurosyphilis can occur within the first few months to several years after infection.  General paresiscan occur between 3 – 30 years after getting syphilis.  People with general paresis can have personality or mood changes.  Tabes dorsalis is characterized by pains in the limbs or abdomen, failure of muscle coordination, and bladder disturbances.  Other signs include vision loss, loss of reflexes and loss of sense of vibration, poor gait, and impaired balance. Tabes dorsalis can occur anywhere from 5 – 50 years after initial syphilis infection.  General paresis and tabes dorsalis are now less common than the other forms of neurosyphilis because of advances made in prevention, screening, and treatment. People with HIV/AIDS are at higher risk of having neurosyphilis.

MalaCards based summary : Neurosyphilis is related to tertiary neurosyphilis and asymptomatic neurosyphilis, and has symptoms including syphilitic chancre An important gene associated with Neurosyphilis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Procaine and Penicillin G have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotypes are hematopoietic system and immune system

Wikipedia : 77 Neurosyphilis refers to infection of the central nervous system in a patient with syphilis and can occur... more...

Related Diseases for Neurosyphilis

Diseases related to Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)
# Related Disease Score Top Affiliating Genes
1 tertiary neurosyphilis 34.1 CXCL10 CXCL13
2 asymptomatic neurosyphilis 33.9 CXCL10 CXCL13 CXCL8 IL17A
3 viral encephalitis 30.0 CXCL10 CXCL8 IL10
4 transverse myelitis 29.9 CXCL8 IL10 IL17A
5 panuveitis 29.9 IL10 IL17A
6 polyradiculoneuropathy 29.9 IL10 IL17A
7 meningitis 29.7 CXCL8 IL10 TLR2
8 malaria 29.7 CXCL10 CXCL8 IL10 IL17A TLR2
9 arthritis 29.7 CXCL8 IL10 IL17A
10 tuberculous meningitis 29.7 CXCL8 TLR2
11 aphthous stomatitis 29.6 IL10 TLR2
12 multiple sclerosis 29.5 CXCL10 IL10 IL17A
13 pneumonia 29.4 CXCL8 IL10 TLR2
14 lyme disease 28.7 IL17A TLR1 TLR2 TLR6
15 meningovascular neurosyphilis 12.5
16 parenchymatous neurosyphilis 12.5
17 tabes dorsalis 11.9
18 late congenital syphilis 11.6
19 argyll robertson pupil 11.4
20 syphilitic aseptic meningitis 11.1
21 aids - neurological complications 11.1
22 cerebral atrophy 11.1
23 syphilis 10.7
24 tertiary syphilis 10.6
25 dementia 10.5
26 encephalitis 10.4
27 status epilepticus 10.4
28 human immunodeficiency virus infectious disease 10.3
29 pyelonephritis 10.3 CXCL8 IL10
30 viral meningitis 10.3 CXCL10 CXCL8
31 apple allergy 10.3 CXCL10 IL10
32 tungiasis 10.3 CXCL8 IL10
33 fungal meningitis 10.3 CXCL10 IL10
34 acute transverse myelitis 10.3 CXCL8 IL10
35 pouchitis 10.3 CXCL8 IL10
36 vulvovaginitis 10.3 CXCL8 IL10
37 scabies 10.3 CXCL8 IL10
38 necatoriasis 10.3 CXCL8 IL10
39 peanut allergy 10.3 CXCL10 IL10
40 glaucomatocyclitic crisis 10.3 CXCL10 CXCL8
41 funisitis 10.3 CXCL8 IL10
42 clonorchiasis 10.3 CXCL8 IL10
43 retinitis pigmentosa 44 10.3 CXCL8 IL10
44 spotted fever 10.3 CXCL10 IL10
45 acute generalized exanthematous pustulosis 10.3 CXCL8 IL17A
46 mycetoma 10.3 CXCL8 IL10
47 tick-borne encephalitis 10.2 CXCL10 IL10
48 aseptic meningitis 10.2 CXCL8 IL10
49 palladium allergic contact dermatitis 10.2 IL10 IL17A
50 diversion colitis 10.2 CXCL13 CXCR5

Comorbidity relations with Neurosyphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Hypertension, Essential
Latent Syphilis Schizophreniform Disorder

Graphical network of the top 20 diseases related to Neurosyphilis:



Diseases related to Neurosyphilis

Symptoms & Phenotypes for Neurosyphilis

UMLS symptoms related to Neurosyphilis:


syphilitic chancre

MGI Mouse Phenotypes related to Neurosyphilis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CXCL10 CXCL13 CXCR5 IL10 IL17A TLR1
2 immune system MP:0005387 9.23 CXCL10 CXCL13 CXCR5 IL10 IL17A TLR1

Drugs & Therapeutics for Neurosyphilis

Drugs for Neurosyphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaine Approved, Investigational, Vet_approved Phase 4,Not Applicable 59-46-1 4914
2
Penicillin G Approved, Vet_approved Phase 4,Not Applicable 61-33-6 5904
3 Anti-Infective Agents Phase 4,Not Applicable
4 Penicillin G Benzathine Phase 4,Not Applicable
5 penicillins Phase 4,Not Applicable
6 Anti-Bacterial Agents Phase 4,Not Applicable
7 Penicillin G Procaine Phase 4,Not Applicable
8
Ceftriaxone Approved Not Applicable 73384-59-5 5479530 5361919

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
3 A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals Completed NCT00000648 Not Applicable Penicillin G potassium;Ceftriaxone sodium
4 Clinical Findings in General Paresis Completed NCT00921648
5 Central Nervous System Infections in Denmark Recruiting NCT03418441
6 Biomarker for Duchenne Disease (BioDuchenne) Recruiting NCT02994030

Search NIH Clinical Center for Neurosyphilis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Neurosyphilis

Anatomical Context for Neurosyphilis

MalaCards organs/tissues related to Neurosyphilis:

42
Brain, Testes, Spinal Cord, Skin, Bone, Eye, T Cells

Publications for Neurosyphilis

Articles related to Neurosyphilis:

(show top 50) (show all 982)
# Title Authors Year
1
Neurosyphilis presenting as cranial nerve palsy, an entity which is easy to miss. ( 30796075 )
2019
2
Neurosyphilis presenting as rapidly progressive psychosis & dementia - A forgotten entity. ( 30785032 )
2019
3
A Case Report of Neurosyphilis Limbic Encephalitis With Reversible Geschwind Syndrome and Mood Disorder. ( 31083037 )
2019
4
Lesson of the month 1: Neurosyphilis mimicking viral encephalitis and ischaemic stroke. ( 31092522 )
2019
5
Atypical development of neurosyphilis mimicking limbic encephalitis. ( 30253732 )
2019
6
Syphilitic hepatitis and neurosyphilis: an observational study of Danish HIV-infected individuals during a 13-year period. ( 30923165 )
2019
7
Predictors of unfavorable outcome in neurosyphilis: Multicenter ID-IRI Study. ( 30368740 )
2019
8
Risk of neurosyphilis in HIV-infected persons with syphilis lacking signs or symptoms of central nervous system infection. ( 30402918 )
2019
9
Early neurosyphilis presenting with multiple cranial nerve palsies: A case report of management by combined penicillin-corticosteroid treatment. ( 30538059 )
2019
10
Generalized Convulsive Status Epilepticus Secondary to Jarisch-Herxheimer Reaction in Neurosyphilis: A Case Report and Literature Review. ( 30586032 )
2019
11
A comparison of nontreponemal tests in cerebrospinal fluid for neurosyphilis diagnosis: equivalent detection of specific antibodies. ( 30810592 )
2019
12
Neurosyphilis: Concordance between cerebrospinal fluid analysis and subsequent antibiotic strategy for patients undergoing evaluation of a diagnosis of neurosyphilis. ( 30853444 )
2019
13
Changes of T lymphocyte subsets in patients with HIV-negative symptomatic neurosyphilis. ( 30862559 )
2019
14
Metabolite Profiles of the Cerebrospinal Fluid in Neurosyphilis Patients Determined by Untargeted Metabolomics Analysis. ( 30863278 )
2019
15
Analysis of EEG Lemple-Ziv complexity and correlative aspects before and after treatment of anti-syphilis therapy for neurosyphilis. ( 30912484 )
2019
16
Exosomal microRNA profiles from serum and cerebrospinal fluid in neurosyphilis. ( 30926713 )
2019
17
Schizophrenia-like psychosis as the presenting feature of neurosyphilis in a non-human immunodeficiency virus-infected Indian man: A reminder of a forgotten complication! ( 30992619 )
2019
18
A Rare Case of Neurosyphilis with Ocular Involvement in a Patient with HIV Infection and New Onset Syphilis. ( 31011497 )
2019
19
Neurosyphilis Presenting with Anxiety: A Case Report. ( 30254809 )
2018
20
Screening for asymptomatic neurosyphilis in HIV patients after treatment of early syphilis: an observational study. ( 28196838 )
2018
21
Newly diagnosed AIDS with neurosyphilis, Kaposi sarcoma, pancytopenia, oropharyngeal candidiasis, and pseudomonal pneumonia: We shouldn't be seeing this anymore. ( 30101071 )
2018
22
Comparison of Clinical and Laboratory Characteristics of General Paresis and Non-Neurosyphilis Dementia. ( 30343296 )
2018
23
Mesial encephalitis: an uncommon presentation of neurosyphilis: a case report and review of the literature. ( 28889343 )
2018
24
Concomitant neurosyphilis and herpes simplex encephalitis in an immunocompetent patient: a case report. ( 28914386 )
2018
25
Meningovascular neurosyphilis with basilar artery thrombosis in HIV patient. ( 28993174 )
2018
26
Neurosyphilis as a Cause of Transverse Myelitis in a Teenage Girl. ( 29602529 )
2018
27
Thomas Mann's depiction of neurosyphilis and other diseases. ( 28471291 )
2018
28
Reported Cases of Neurosyphilis Among Early Syphilis Cases-United States, 2009 to 2015. ( 28876294 )
2018
29
MRI findings in a case of Lissauer form of neurosyphilis. ( 28939990 )
2018
30
How Well Do Neurologic Symptoms Identify Individuals With Neurosyphilis? ( 29020214 )
2018
31
Biological false-positive venereal disease research laboratory test in cerebrospinal fluid in the diagnosis of neurosyphilis - a case-control study. ( 29117430 )
2018
32
Historical reflections on neurosyphilis based on the 1826 treatise on general paralysis in demented patients by Louis Florentin Calmeil (1798-1895). ( 29169563 )
2018
33
Diverse clinical presentations of neurosyphilis: focus on differential diagnosis. ( 29181654 )
2018
34
Diversity in clinical manifestations and imaging features of neurosyphilis: obstacles to the diagnosis and treatment (report of three cases). ( 29199527 )
2018
35
Diplopia: An Overlooked Feature in Patients With Neurosyphilis. Report of 2 Cases and Literature Review. ( 29329180 )
2018
36
Management of neurosyphilis: time for a new approach? ( 29415349 )
2018
37
Neurosyphilis: Knowledge Gaps and Controversies. ( 29420441 )
2018
38
A case of very early neurosyphilis presented as schizophrenia-like psychosis. ( 29453149 )
2018
39
Neurosyphilis in patients with HIV. ( 29478035 )
2018
40
The clinical and laboratory features of neurosyphilis in HIV-infected patients: A retrospective study in 92 patients. ( 29489672 )
2018
41
Teaching NeuroImages: Gummatous neurosyphilis: An atypical presentation in a patient with HIV. ( 29507143 )
2018
42
Dilated tonic pupils with tabes dorsalis in neurosyphilis as first manifestation of HIV/AIDS: a video report. ( 29545440 )
2018
43
Postmortem Histopathologic Analysis of Neurosyphilis: A Report of 3 Cases With Clinicopathologic Correlations. ( 29546365 )
2018
44
Neurosyphilis with Bilateral Optic Perineuritis in an Immunocompetent Patient. ( 29566376 )
2018
45
The performance of rapid plasma reagin (RPR) titer in HIV-negative general paresis after neurosyphilis therapy. ( 29606102 )
2018
46
Electroclinical and radiological observation of dysfunctional zones in a patient with neurosyphilis. ( 29620006 )
2018
47
Different Faces of Neurosyphilis. ( 29624563 )
2018
48
Ischemic Stroke in an HIV Positive Patient: An Initial Presentation of Neurosyphilis. ( 29666731 )
2018
49
Neurosyphilis: mighty imitator forays with benign presentation and unique neuroimaging findings. ( 29706150 )
2018
50
Study on influence factors related to antibiotic treatment of neurosyphilis. ( 29877685 )
2018

Variations for Neurosyphilis

Expression for Neurosyphilis

Search GEO for disease gene expression data for Neurosyphilis.

Pathways for Neurosyphilis

Pathways related to Neurosyphilis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 CXCL10 CXCL8 IL10 IL17A TLR1 TLR2
2
Show member pathways
13.61 CXCL10 CXCL13 CXCL8 CXCR5 IL10 IL17A
3
Show member pathways
13.45 CXCL10 CXCL13 CXCL8 CXCR5 IL10 IL17A
4
Show member pathways
13.1 CXCL10 CXCL13 CXCL8 CXCR5 IL10 IL17A
5
Show member pathways
12.85 CXCL10 CXCL8 IL10 TLR1 TLR2 TLR6
6
Show member pathways
12.76 CXCL10 CXCL13 CXCL8 CXCR5 IL10 IL17A
7
Show member pathways
12.7 CXCL13 CXCL8 CXCR5 IL10 IL17A
8
Show member pathways
12.69 CXCL10 CXCL13 CXCL8 CXCR5
9
Show member pathways
12.27 TLR1 TLR2 TLR6
10
Show member pathways
12.2 TLR1 TLR2 TLR6
11
Show member pathways
12.18 CXCL10 CXCL8 IL17A TLR2
12
Show member pathways
12.07 CXCL8 TLR1 TLR2 TLR6
13 12.03 IL10 TLR1 TLR2 TLR6
14 12.02 TLR1 TLR2 TLR6
15
Show member pathways
11.98 CXCL10 CXCL13 CXCL8 TLR1 TLR2 TLR6
16
Show member pathways
11.89 TLR1 TLR2 TLR6
17
Show member pathways
11.88 TLR1 TLR2 TLR6
18
Show member pathways
11.87 CXCL10 CXCL8 TLR1 TLR2 TLR6
19 11.84 CXCL8 IL10 IL17A
20
Show member pathways
11.82 CXCL10 CXCL13 CXCL8 CXCR5
21 11.76 CXCL8 IL10 TLR2
22 11.73 CXCL8 IL17A TLR2
23 11.69 TLR1 TLR2 TLR6
24 11.68 CXCL10 CXCR5 IL10 IL17A TLR1 TLR2
25
Show member pathways
11.67 IL10 IL17A TLR1 TLR2 TLR6
26 11.66 CXCR5 IL10 IL17A
27 11.52 CXCL10 CXCL13 IL10 IL17A
28 11.4 CXCL10 CXCL8 IL10
29 11.39 CXCL8 IL10 TLR2
30 11.18 CXCL10 CXCL13
31 11.04 TLR1 TLR2
32 10.95 CXCL10 CXCL13 CXCL8 IL10 IL17A
33 10.81 CXCL10 CXCL13 CXCL8 IL10 IL17A

GO Terms for Neurosyphilis

Cellular components related to Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.33 TLR1 TLR2 TLR6
2 phagocytic vesicle membrane GO:0030670 9.13 TLR1 TLR2 TLR6
3 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Neurosyphilis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.91 CXCL10 CXCL8 IL10 IL17A
2 regulation of signaling receptor activity GO:0010469 9.89 CXCL10 CXCL13 CXCL8 IL10 IL17A
3 defense response to bacterium GO:0042742 9.84 CXCL13 IL10 TLR6
4 cell-cell signaling GO:0007267 9.83 CXCL10 CXCL13 IL17A
5 response to lipopolysaccharide GO:0032496 9.83 CXCL10 IL10 TLR2
6 cellular response to lipopolysaccharide GO:0071222 9.81 CXCL10 CXCL13 CXCL8 IL10
7 cell chemotaxis GO:0060326 9.8 CXCL10 CXCL13 CXCR5
8 neutrophil chemotaxis GO:0030593 9.8 CXCL10 CXCL13 CXCL8
9 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.78 CXCL10 CXCL13 CXCL8
10 chemotaxis GO:0006935 9.76 CXCL10 CXCL13 CXCL8 CXCR5
11 toll-like receptor signaling pathway GO:0002224 9.73 TLR1 TLR2 TLR6
12 defense response GO:0006952 9.73 CXCL10 CXCL13 CXCL8 TLR1
13 microglial cell activation GO:0001774 9.65 TLR2 TLR6
14 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.65 IL17A TLR6
15 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.65 TLR1 TLR2 TLR6
16 positive regulation of macrophage activation GO:0043032 9.64 IL10 TLR6
17 positive regulation of interleukin-8 secretion GO:2000484 9.64 TLR1 TLR2
18 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.62 TLR1 TLR6
19 cellular response to diacyl bacterial lipopeptide GO:0071726 9.6 TLR2 TLR6
20 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.59 TLR2 TLR6
21 cellular response to triacyl bacterial lipopeptide GO:0071727 9.58 TLR1 TLR2
22 nitric oxide metabolic process GO:0046209 9.58 TLR2 TLR6
23 regulation of cytokine secretion GO:0050707 9.58 TLR1 TLR2 TLR6
24 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.57 TLR1 TLR2
25 chemokine-mediated signaling pathway GO:0070098 9.56 CXCL10 CXCL13 CXCL8 CXCR5
26 inflammatory response GO:0006954 9.56 CXCL10 CXCL13 CXCL8 IL10 IL17A TLR1
27 detection of diacyl bacterial lipopeptide GO:0042496 9.55 TLR2 TLR6
28 leukocyte chemotaxis GO:0030595 9.55 CXCL10 CXCL13 CXCL8 CXCR5 IL10
29 detection of triacyl bacterial lipopeptide GO:0042495 9.54 TLR1 TLR2
30 cell activation GO:0001775 9.54 TLR1 TLR2 TLR6
31 response to bacterial lipoprotein GO:0032493 9.52 TLR2 TLR6
32 response to molecule of bacterial origin GO:0002237 9.5 CXCL8 IL10 TLR2
33 immune response GO:0006955 9.28 CXCL10 CXCL13 CXCL8 CXCR5 IL10 IL17A
34 signal transduction GO:0007165 10.11 CXCL10 CXCL8 CXCR5 TLR1 TLR2 TLR6

Molecular functions related to Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.67 CXCL13 TLR1 TLR2 TLR6
2 signaling receptor activity GO:0038023 9.58 TLR1 TLR2 TLR6
3 chemokine activity GO:0008009 9.43 CXCL10 CXCL13 CXCL8
4 CXCR3 chemokine receptor binding GO:0048248 9.32 CXCL10 CXCL13
5 Toll-like receptor 2 binding GO:0035663 9.16 TLR1 TLR6
6 lipopeptide binding GO:0071723 9.13 TLR1 TLR2 TLR6
7 cytokine activity GO:0005125 9.02 CXCL10 CXCL13 CXCL8 IL10 IL17A

Sources for Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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