MCID: NRT001
MIFTS: 51

Neurotic Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Neurotic Disorder

MalaCards integrated aliases for Neurotic Disorder:

Name: Neurotic Disorder 12 15
Neurosis 12 37 15
Adjustment Disorders 44 73
Reactive Depression 12 73
Neurotic Disorders 44 73
Neurotic Depression Reactive Type 12
Neurotic Depressive State 12
Depression, Neurotic 73
Depressive Neurosis 12
Neurotic Depression 12
Depressive Disorder 73
Psychoneurosis 12

Classifications:



Summaries for Neurotic Disorder

Disease Ontology : 12 An anxiety disorder that involves discress but neither delusions nor hallucinations.

MalaCards based summary : Neurotic Disorder, also known as neurosis, is related to premenstrual tension and adjustment disorder, and has symptoms including depressed reaction and depressed - symptom. An important gene associated with Neurotic Disorder is MFSD8 (Major Facilitator Superfamily Domain Containing 8), and among its related pathways/superpathways are Neuroactive ligand-receptor interaction and Dopaminergic synapse. The drugs Citalopram and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include heart, breast and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Neurosis is a class of functional mental disorders involving chronic distress but neither delusions nor... more...

Related Diseases for Neurotic Disorder

Diseases related to Neurotic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 premenstrual tension 29.5 CAMP LIPN
2 adjustment disorder 12.7
3 obsessive-compulsive disorder 11.6
4 conversion disorder 11.5
5 orthostatic intolerance 11.4
6 hypochondriasis 11.3
7 post-traumatic stress disorder 11.3
8 panic disorder 1 11.2
9 wilson disease 11.1
10 combat disorder 11.0
11 depression 10.4
12 panic disorder 10.2
13 head injury 10.2
14 personality disorder 10.1
15 dissociative disorder 10.1
16 asthma 10.1
17 raynaud disease 10.1
18 pellagra 10.1
19 depersonalization disorder 10.0
20 heart disease 10.0
21 diabetes insipidus 10.0
22 phobic disorder 10.0 GLRB HTR1A
23 agoraphobia 10.0 GLRB HTR1A
24 depersonalization/derealization disorder 10.0
25 miller-dieker lissencephaly syndrome 9.9 GPX4 LY96
26 ring dermoid of cornea 9.9
27 anorexia nervosa 9.9
28 arthritis 9.9
29 body dysmorphic disorder 9.9
30 stuttering 9.9
31 physical disorder 9.9
32 dementia 9.9
33 biliary dyskinesia 9.9
34 peptic ulcer disease 9.9
35 hypoglycemia 9.9
36 mitral valve prolapse, familial, x-linked 9.9
37 schizophrenia 9.9
38 anxiety 9.9
39 generalized anxiety disorder 9.9
40 major depressive disorder 9.9
41 mood disorder 9.9
42 arteries, anomalies of 9.8
43 rheumatoid arthritis 9.8
44 torticollis 9.8
45 autism 9.8
46 adrenoleukodystrophy 9.8
47 schizophrenia 3 9.8
48 myocardial infarction 9.8
49 angina pectoris 9.8
50 coronary artery anomaly 9.8

Graphical network of the top 20 diseases related to Neurotic Disorder:



Diseases related to Neurotic Disorder

Symptoms & Phenotypes for Neurotic Disorder

UMLS symptoms related to Neurotic Disorder:


depressed reaction, depressed - symptom

GenomeRNAi Phenotypes related to Neurotic Disorder according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.53 SLC22A12
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.53 ATP6V0D2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.53 ATP6V0D2 GPX4 SLC22A12
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.53 GPX4
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.53 SLC22A12
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.53 ATP6V0D2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.53 ATP6V0D2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.53 SLC22A12
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.53 SLC22A12
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.53 ATP6V0D2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.53 ATP6V0D2 SLC22A12
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.53 SLC22A12
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.53 ATP6V0D2

MGI Mouse Phenotypes related to Neurotic Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 GABRA6 GLRB GPX4 HTR1A MFSD8 SLC22A12

Drugs & Therapeutics for Neurotic Disorder

Drugs for Neurotic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
2
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
3 tannic acid Approved Phase 4
4 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
5 Antiparkinson Agents Phase 4,Phase 2
6 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
7 Cholinergic Agents Phase 4,Phase 2
8 Cholinergic Antagonists Phase 4,Phase 2
9 Muscarinic Antagonists Phase 4,Phase 2
10 Serotonin Uptake Inhibitors Phase 4,Phase 2
11 Serotonin Agents Phase 4,Phase 2
12 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
13 Antidepressive Agents Phase 4,Phase 3,Phase 2
14 Antidepressive Agents, Second-Generation Phase 4,Phase 2
15 Parasympatholytics Phase 4,Phase 2
16 Psychotropic Drugs Phase 4,Phase 3,Phase 2
17 Autonomic Agents Phase 4,Phase 3,Phase 2
18
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 50-67-9 5202
19
Budesonide Approved Phase 3 51333-22-3 63006 5281004
20
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
21
Norepinephrine Approved Phase 3 51-41-2 439260
22
Pregabalin Approved, Illicit, Investigational Phase 3 148553-50-8 5486971
23
Peppermint Approved Phase 3
24
Dronabinol Approved, Illicit Phase 3 1972-08-3 16078
25
Peppermint oil Approved, Investigational Phase 3 8006-90-4
26
Ethanol Approved Phase 3 64-17-5 702
27 Anti-Inflammatory Agents Phase 3
28 Hormones Phase 3
29 Hormone Antagonists Phase 3
30 Anti-Asthmatic Agents Phase 3
31 Respiratory System Agents Phase 3
32 glucocorticoids Phase 3
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
34 Bronchodilator Agents Phase 3
35 Dopamine Agents Phase 3
36 Duloxetine Hydrochloride Phase 3
37 Analgesics Phase 3,Phase 2
38 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
39 Central Nervous System Depressants Phase 3,Phase 2
40 Anticonvulsants Phase 3,Phase 2
41 Anti-Anxiety Agents Phase 3
42 Calcium, Dietary Phase 3,Phase 2
43 Tranquilizing Agents Phase 3
44 calcium channel blockers Phase 3,Phase 2
45 Antipsychotic Agents Phase 3
46 Quetiapine Fumarate Phase 3 111974-72-2
47 Cannabinoid Receptor Agonists Phase 3
48 Hallucinogens Phase 3
49 Analgesics, Non-Narcotic Phase 3
50
Lamotrigine Approved, Investigational Phase 2 84057-84-1 3878

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Clinical Trial of Tenoten® in the Treatment of Anxiety in Patients With Somatoform, Stress-related and Other Neurotic Disorders Completed NCT03036293 Phase 4 Tenoten;Placebo
2 Cognitive-Behavioral Therapy and Escitalopram for Generalized Anxiety Disorder(GAD) Completed NCT00219349 Phase 4 escitalopram
3 Veterans Individual Placement and Support Towards Advancing Recovery Completed NCT01817712 Phase 4
4 A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder Unknown status NCT00978484 Phase 3
5 Efficacy and Safety of Inhaled Budesonide in Very Preterm Infants at Risk for Bronchopulmonary Dysplasia Completed NCT01035190 Phase 3 Budesonide
6 A Study in Pediatric Participants With Generalized Anxiety Disorder Completed NCT01226511 Phase 3 Duloxetine;Placebo
7 Determine Long-Term Safety and Tolerability of Pregabalin in Patients With Anxiety Disorders. Completed NCT00150449 Phase 3 Pregabalin
8 Generalized Anxiety Disorder Adjunct Study Completed NCT00534599 Phase 3 Placebo;quetiapine fumarate XR
9 An Investigation of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosis Patients Completed NCT01610700 Phase 3 GW-1000-02;Placebo
10 A Study of Sativex® for Relief of Peripheral Neuropathic Pain Associated With Allodynia. Completed NCT00711880 Phase 3 Sativex®;Placebo
11 An Study to Investigate the Efficacy of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosis Completed NCT01610713 Phase 3 GW-1000-02
12 Clinical Trial of Safety and Efficacy of Afalaza in Patients With Symptoms of Benign Prostatic Hyperplasia and Risk of Progression Completed NCT01716104 Phase 3 Afalaza;Placebo
13 Study to Evaluate Efficacy and Safety of Roluperidone (MIN-101) in Adult Patients With Negative Symptoms of Schizophrenia Recruiting NCT03397134 Phase 3 Placebo Oral Tablet;Roluperidone 32 mg;Roluperidone 64 mg
14 An Open-Label Study Of Lamictal In Neurotic Excoriation Completed NCT00269594 Phase 2 Lamictal (lamotrigine)
15 Fast-Fail Trials in Mood and Anxiety Spectrum Disorders; Kappa Opioid Receptor Phase 2a Completed NCT02218736 Phase 2 CERC-501;placebo
16 Nexalin Therapy for the Treatment of Depressive Symptoms Completed NCT00774813 Phase 2 placebo device and Citalopram
17 Efficacy and Safety of S 47445 Versus Placebo as Adjunctive Treatment in Depressed Patients Not Fully Recovered From Depressive Symptoms With a Current Antidepressant Treatment Completed NCT02805439 Phase 2 S47445 15mg;S47445 50mg;Placebo
18 A Clinical Study to Test the Effectiveness of an Investigational Drug to Treat People That Have Major Depressive Episodes When They Have Bipolar 1 Depression Recruiting NCT03543410 Phase 2 SEP-4199 200 mg;SEP-4199 400 mg;Placebo
19 Effectiveness of Online Systematic Brief Psychodynamic Psychotherapy for Neurotic Disorders: Randomized Controlled Trial Unknown status NCT02257996 Not Applicable
20 Evaluation of the Texas Wellness Incentives and Navigation (WIN) Project Completed NCT02440906 Not Applicable
21 Parent-Augmented Cognitive Behavioral Therapy to Treat Children With Specific Phobias Completed NCT00509951 Not Applicable
22 Psychotherapy Treatment of Deployment-Related PTSD in Primary Care Settings Completed NCT00974402 Not Applicable
23 Cognitive and Psychosocial Outcome After Mild Traumatic Brain Injury Completed NCT02161172
24 An Adjunctive Family Intervention for Individual Posttraumatic Stress Disorder Treatment Recruiting NCT02956434 Not Applicable
25 Implementation and Evaluation of a Family-based Intervention Program for Children of Mentally Ill Parents Active, not recruiting NCT02308462 Not Applicable
26 Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions Terminated NCT01307475

Search NIH Clinical Center for Neurotic Disorder

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: adjustment disorders

Genetic Tests for Neurotic Disorder

Anatomical Context for Neurotic Disorder

MalaCards organs/tissues related to Neurotic Disorder:

41
Heart, Breast, Lung, Testes, Brain, Whole Blood, Cortex

Publications for Neurotic Disorder

Articles related to Neurotic Disorder:

(show top 50) (show all 1078)
# Title Authors Year
1
Economic evaluation of mindfulness group therapy for patients with depression, anxiety, stress and adjustment disorders compared with treatment as usual. ( 30468136 )
2018
2
"The Neurosis That Has Possessed Us": Political Repression in the Cold War Medical Profession. ( 29718289 )
2018
3
Hallucination in Adolescence-Or, Nora in Nowhereland Between Neurosis and Psychosis. ( 30300083 )
2018
4
Insights Into Aspects Behind Internet-Related Disorders in Adolescents: The Interplay of Personality and Symptoms of Adjustment Disorders. ( 29174875 )
2018
5
Macrophage Migration Inhibitory Factor and microRNA-451a in Response to Mindfulness-based Therapy or Treatment as Usual in Patients with Depression, Anxiety, or Stress and Adjustment Disorders. ( 29373661 )
2018
6
Long-term improvements after mindfulness-based group therapy of depression, anxiety and stress and adjustment disorders: A randomized controlled trial. ( 29968371 )
2018
7
The psychobiology of stress, depression, adjustment disorders and resilience. ( 30204561 )
2018
8
Psychotherapy of adjustment disorders: Current state and future directions. ( 30204563 )
2018
9
Kraepelin's views on obsessive neurosis: a comparison with DSM-5 criteria for obsessive-compulsive disorder. ( 28300946 )
2017
10
Effects of cultured Cordyceps mycelia polysaccharide A on tumor neurosis factor-α induced hepatocyte injury with mitochondrial abnormality. ( 28267517 )
2017
11
Inhaled Glucocorticoids and Pneumonia in Preterm Infants: Post Hoc Results from the NEuroSIS Trial. ( 28456800 )
2017
12
Maldonado, J.L. & Solimano, A.L. (2016). 'Reflections on trauma, symbolization and psychic pain in a case of neurosis and a case of psychosis'. International Journal of Psychoanalysis, 97, 5, 1299-1320. ( 28776649 )
2017
13
Hypochondria as an actual neurosis. ( 28960345 )
2017
14
Treatment of the Opium Neurosis: By Stephen Lett, M.D., Ont., Canada. ( 29067412 )
2017
15
The exchange of monoamines during the experimental neurosis on the background of using of amide "2-hydroxy-n-naphthalen-1-yl-2-(2-oxo-,2-dihydroindol-3-ylidene)". ( 29203736 )
2017
16
Prevalence of depression, anxiety, adjustment disorders, and somatoform disorders in patients with age-related macular degeneration in Germany. ( 28243189 )
2017
17
Leukocyte telomere length and depression, anxiety and stress and adjustment disorders in primary health care patients. ( 28438147 )
2017
18
Association of mitochondrial DNA in peripheral blood with depression, anxiety and stress- and adjustment disorders in primary health care patients. ( 28647451 )
2017
19
Risk of depression, anxiety, and adjustment disorders in women with a suspected but unconfirmed diagnosis of breast or genital organ cancer in Germany. ( 28856543 )
2017
20
Prevalence of depression, anxiety, and adjustment disorders in women with spontaneous abortion in Germany - A retrospective cohort study. ( 28865722 )
2017
21
Cognitive behavioral group therapy for patients with physical diseases and comorbid depressive or adjustment disorders on a waiting list for individual therapy: results from a randomized controlled trial. ( 29017481 )
2017
22
Economic Stress and Mental Health: The Relationship Between the Stock Market and Neurotic Disorder Doctor Visits. ( 27017837 )
2016
23
Vallejo-Nágera (1926-1990) and the concept of 'soteric neurosis': a forgotten sketch of hoarding disorder in the obsessive-compulsive spectrum literature. ( 24658218 )
2016
24
Cats on the Couch: The Experimental Production of Animal Neurosis. ( 26903373 )
2016
25
Reflections on trauma, symbolization and psychic pain in a case of neurosis and a case of psychosis. ( 27059446 )
2016
26
Postpartum anxiety and adjustment disorders in parents of infants with very low birth weight: Cross-sectional results from a controlled multicentre cohort study. ( 26820762 )
2016
27
The association between mood, anxiety and adjustment disorders and hospitalization following lung transplantation. ( 27302717 )
2016
28
Re-conceptualizing Neurosis as a Degree of Egocentricity: Ethical Issues in Psychological Theory. ( 25216966 )
2015
29
Neurosis Meets Psychosis: Case Series from a Tertiary Care Center in South India. ( 26664092 )
2015
30
The Major Mobilization of the Unconscious and the Total Removal of Resistance in Davanloo's Intensive Short-term Dynamic Psychotherapy Part II: Treating the Transference Neurosis. ( 26802424 )
2015
31
Mindfulness group therapy in primary care patients with depression, anxiety and stress and adjustment disorders: randomised controlled trial. ( 25431430 )
2015
32
Immediate help through group therapy for patients with somatic diseases and depressive or adjustment disorders in outpatient care: study protocol for a randomized controlled trial. ( 26116561 )
2015
33
Trauma, comorbidity, and mortality following diagnoses of severe stress and adjustment disorders: a nationwide cohort study. ( 26243737 )
2015
34
Adjustment Disorders Are Uniquely Suited for eHealth Interventions: Concept and Case Study. ( 26543920 )
2015
35
Body dysmorphic disorder: Borderline category between neurosis and psychosis. ( 24574566 )
2014
36
It is never too late to treat anxiety neurosis or panic disorder with a serotonin-reuptake inhibitor. ( 25988044 )
2014
37
Dissociative disorders: between neurosis and psychosis. ( 25405051 )
2014
38
Whither the psychosis-neurosis borderline. ( 24436054 )
2014
39
Adjustment disorders in Asians and Asian Americans. ( 24524713 )
2014
40
Adjustment disorders as a stress-related disorder: a longitudinal study of the associations among stress, resources, and mental health. ( 24825165 )
2014
41
Body dysmorphic disorder: Borderline category between neurosis and psychosis. ( 24459311 )
2013
42
Why nature doesn't turn off neurosis. ( 21409479 )
2013
43
The great neurosis of Dr. Joseph Gerard. ( 23485892 )
2013
44
Is 'depression' the new 'neurosis'? ( 23568154 )
2013
45
The effects of mental health parity on spending and utilization for bipolar, major depression, and adjustment disorders. ( 23377639 )
2013
46
Should adjustment disorder be conceptualized as transitional disorder? In pursuit of adjustment disorders definition. ( 22548438 )
2012
47
Aspects of narcissism and symbiosis, or, essential neurosis of twins. ( 22712590 )
2012
48
Compensation neurosis: a too quickly forgotten concept? ( 22960922 )
2012
49
From sensorimotor inhibition to freudian repression: insights from psychosis applied to neurosis. ( 23162501 )
2012
50
Efficacy of nursing interventions in reducing social and occupational disabilities among patients with neurosis. ( 23923597 )
2012

Variations for Neurotic Disorder

Expression for Neurotic Disorder

Search GEO for disease gene expression data for Neurotic Disorder.

Pathways for Neurotic Disorder

Pathways related to Neurotic Disorder according to KEGG:

37
# Name Kegg Source Accession
1 Neuroactive ligand-receptor interaction hsa04080
2 Dopaminergic synapse hsa04728

Pathways related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.63 ATP6V0D2 GABRA6 GLRB
2
Show member pathways
10.25 GABRA6 GLRB

GO Terms for Neurotic Disorder

Cellular components related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chloride channel complex GO:0034707 8.62 GABRA6 GLRB

Biological processes related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.33 ATP6V0D2 GABRA6 GLRB
2 nervous system process GO:0050877 9.26 GABRA6 GLRB
3 chemical synaptic transmission GO:0007268 9.13 GABRA6 GLRB HTR1A
4 ion transport GO:0006811 8.92 ATP6V0D2 GABRA6 GLRB SLC22A12

Molecular functions related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chloride channel activity GO:0005254 9.26 GABRA6 GLRB
2 extracellular ligand-gated ion channel activity GO:0005230 9.16 GABRA6 GLRB
3 lipopolysaccharide binding GO:0001530 8.96 CAMP LY96
4 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 8.62 GABRA6 GLRB

Sources for Neurotic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....