MCID: NRT001
MIFTS: 47

Neurotic Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Neurotic Disorder

MalaCards integrated aliases for Neurotic Disorder:

Name: Neurotic Disorder 12 15 17
Neurosis 12 38 15
Adjustment Disorders 45 74
Reactive Depression 12 74
Neurotic Disorders 45 74
Neurotic Depression Reactive Type 12
Neurotic Depressive State 12
Depression, Neurotic 74
Depressive Neurosis 12
Neurotic Depression 12
Depressive Disorder 74
Psychoneurosis 12

Classifications:



Summaries for Neurotic Disorder

Disease Ontology : 12 An anxiety disorder that involves discress but neither delusions nor hallucinations.

MalaCards based summary : Neurotic Disorder, also known as neurosis, is related to premenstrual tension and adjustment disorder, and has symptoms including depressed reaction and depressed - symptom. An important gene associated with Neurotic Disorder is MFSD8 (Major Facilitator Superfamily Domain Containing 8), and among its related pathways/superpathways are Neuroactive ligand-receptor interaction and Dopaminergic synapse. The drugs Citalopram and Psychotropic Drugs have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related phenotypes are Dynamic nuclei (hole, folded or small irregular) and hematopoietic system

Wikipedia : 77 Neurosis is a class of functional mental disorders involving chronic distress but neither delusions nor... more...

Related Diseases for Neurotic Disorder

Diseases related to Neurotic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 premenstrual tension 29.2 CAMP LIPN LRP5
2 adjustment disorder 12.8
3 obsessive-compulsive disorder 11.7
4 conversion disorder 11.5
5 orthostatic intolerance 11.4
6 hypochondriasis 11.4
7 post-traumatic stress disorder 11.4
8 panic disorder 1 11.3
9 wilson disease 11.1
10 combat disorder 11.0
11 depression 10.4
12 enthesopathy 10.3
13 head injury 10.2
14 panic disorder 10.2
15 dissociative disorder 10.2
16 personality disorder 10.1
17 asthma 10.1
18 heart disease 10.1
19 raynaud disease 10.1
20 pellagra 10.1
21 anorexia nervosa 10.0
22 depersonalization disorder 10.0
23 duodenal ulcer 10.0
24 epilepsy 10.0
25 diabetes insipidus 10.0
26 hypoglycemia 10.0
27 depersonalization/derealization disorder 10.0
28 arthritis 9.9
29 body dysmorphic disorder 9.9
30 stuttering 9.9
31 physical disorder 9.9
32 amnestic disorder 9.9
33 dementia 9.9
34 gout 9.9
35 biliary dyskinesia 9.9
36 peptic ulcer disease 9.9
37 hyperthyroidism 9.9
38 mitral valve prolapse, familial, x-linked 9.9
39 ring dermoid of cornea 9.9
40 major depressive disorder 9.9
41 mental depression 9.9
42 miller-dieker lissencephaly syndrome 9.9 GPX4 LY96
43 facial paralysis 9.9 LIPN LRP5
44 schizophrenia 9.9
45 anxiety 9.9
46 generalized anxiety disorder 9.9
47 disease of mental health 9.9
48 mood disorder 9.9
49 facial nerve disease 9.9 LIPN LRP5
50 arteries, anomalies of 9.8

Graphical network of the top 20 diseases related to Neurotic Disorder:



Diseases related to Neurotic Disorder

Symptoms & Phenotypes for Neurotic Disorder

UMLS symptoms related to Neurotic Disorder:


depressed reaction, depressed - symptom

GenomeRNAi Phenotypes related to Neurotic Disorder according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Dynamic nuclei (hole, folded or small irregular) GR00257-A-1 9.1 GABRA6 GPX4 HTR1A LRP5 PCSK5 SLC22A12

MGI Mouse Phenotypes related to Neurotic Disorder:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 CAMP LRP5 LY96 MFSD8 PCSK5 SLC22A12
2 nervous system MP:0003631 9.23 GABRA6 GPX4 HTR1A LRP5 MFSD8 PCSK5

Drugs & Therapeutics for Neurotic Disorder

Drugs for Neurotic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
2 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Not Applicable
3 Antiparkinson Agents Phase 4,Phase 2
4 Autonomic Agents Phase 4,Phase 3,Phase 2
5 Parasympatholytics Phase 4,Phase 2
6 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
7 Cholinergic Antagonists Phase 4,Phase 2
8 Serotonin Agents Phase 4,Phase 3,Phase 2
9 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
10 Serotonin Uptake Inhibitors Phase 4,Phase 2
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
12 Muscarinic Antagonists Phase 4,Phase 2
13 Antidepressive Agents, Second-Generation Phase 4,Phase 2
14 Antidepressive Agents Phase 4,Phase 3,Phase 2
15 Cholinergic Agents Phase 4,Phase 2
16
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 50-67-9 5202
17
Budesonide Approved Phase 3 51333-22-3 5281004 63006
18
Norepinephrine Approved Phase 3 51-41-2 439260
19
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
20
Pregabalin Approved, Illicit, Investigational Phase 3 148553-50-8 5486971
21
Dronabinol Approved, Illicit Phase 3 1972-08-3 16078
22
Ethanol Approved Phase 3 64-17-5 702
23
Peppermint oil Approved, Investigational Phase 3 8006-90-4
24
Peppermint Approved Phase 3
25
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
26
Propranolol Approved, Investigational Phase 2, Phase 3 525-66-6 4946
27
Calcium Approved, Nutraceutical Phase 3,Phase 2 7440-70-2 271
28 Nabiximols Investigational Phase 3 56575-23-6
29 Anti-Inflammatory Agents Phase 3
30 Hormone Antagonists Phase 3
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
32 Hormones Phase 3,Phase 2
33 Respiratory System Agents Phase 3
34 glucocorticoids Phase 3
35 Bronchodilator Agents Phase 3
36 Anti-Asthmatic Agents Phase 3
37 Duloxetine Hydrochloride Phase 3
38 Analgesics Phase 3,Phase 2
39 Dopamine Agents Phase 3
40 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
41 Anti-Anxiety Agents Phase 3
42 Tranquilizing Agents Phase 3,Phase 2
43 Anticonvulsants Phase 3,Phase 2
44 Calcium, Dietary Phase 3,Phase 2
45 Central Nervous System Depressants Phase 3,Phase 2
46 calcium channel blockers Phase 3,Phase 2
47 Antipsychotic Agents Phase 3,Phase 2
48 Quetiapine Fumarate Phase 3 111974-72-2
49 Epidiolex Phase 3
50 Analgesics, Non-Narcotic Phase 3

Interventional clinical trials:

(show top 50) (show all 75)
# Name Status NCT ID Phase Drugs
1 Clinical Trial of Tenoten® in the Treatment of Anxiety in Patients With Somatoform, Stress-related and Other Neurotic Disorders Completed NCT03036293 Phase 4 Tenoten;Placebo
2 Cognitive-Behavioral Therapy and Escitalopram for Generalized Anxiety Disorder(GAD) Completed NCT00219349 Phase 4 escitalopram
3 A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder Unknown status NCT00978484 Phase 3
4 Efficacy and Safety of Inhaled Budesonide in Very Preterm Infants at Risk for Bronchopulmonary Dysplasia Completed NCT01035190 Phase 3 Budesonide
5 A Study in Pediatric Participants With Generalized Anxiety Disorder Completed NCT01226511 Phase 3 Duloxetine;Placebo
6 Determine Long-Term Safety and Tolerability of Pregabalin in Patients With Anxiety Disorders. Completed NCT00150449 Phase 3 Pregabalin
7 Generalized Anxiety Disorder Adjunct Study Completed NCT00534599 Phase 3 Placebo;quetiapine fumarate XR
8 An Investigation of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosis Patients Completed NCT01610700 Phase 3 GW-1000-02;Placebo
9 A Study of Sativex® for Relief of Peripheral Neuropathic Pain Associated With Allodynia. Completed NCT00711880 Phase 3 Sativex®;Placebo
10 An Study to Investigate the Efficacy of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosis Completed NCT01610713 Phase 3 GW-1000-02
11 Clinical Trial of Safety and Efficacy of Afalaza in Patients With Symptoms of Benign Prostatic Hyperplasia and Risk of Progression Completed NCT01716104 Phase 3 Afalaza;Placebo
12 Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone. Completed NCT00399698 Phase 3 Risperdal
13 Study to Evaluate Efficacy and Safety of Roluperidone (MIN-101) in Adult Patients With Negative Symptoms of Schizophrenia Recruiting NCT03397134 Phase 3 Placebo Oral Tablet;Roluperidone 32 mg;Roluperidone 64 mg
14 The Trauma of Betrayal: Treating Adjustment Disorder With Reconsolidation Blockade Under Propranolol Recruiting NCT03151681 Phase 2, Phase 3 Propranolol Pill
15 An Open-Label Study Of Lamictal In Neurotic Excoriation Completed NCT00269594 Phase 2 Lamictal (lamotrigine)
16 Fast-Fail Trials in Mood and Anxiety Spectrum Disorders; Kappa Opioid Receptor Phase 2a Completed NCT02218736 Phase 2 CERC-501;placebo
17 Nexalin Therapy for the Treatment of Depressive Symptoms Completed NCT00774813 Phase 2 placebo device and Citalopram
18 Efficacy and Safety of S 47445 Versus Placebo as Adjunctive Treatment in Depressed Patients Not Fully Recovered From Depressive Symptoms With a Current Antidepressant Treatment Completed NCT02805439 Phase 2 S47445 15mg;S47445 50mg;Placebo
19 Depression Prevention for Pregnant Women on Public Assistance Completed NCT00601757 Phase 2
20 The Efficacy of Parent Involvement in the Treatment of Adolescent Depression Completed NCT00883519 Phase 1, Phase 2
21 Group Interpersonal Psychotherapy for Depressed Adolescents in School-based Clinics Completed NCT00270244 Phase 2
22 A Clinical Study to Test the Effectiveness of an Investigational Drug to Treat People That Have Major Depressive Episodes When They Have Bipolar 1 Depression Recruiting NCT03543410 Phase 2 SEP-4199 200 mg;SEP-4199 400 mg;Placebo
23 Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators Recruiting NCT03152175 Phase 2 Propranolol Hydrochloride;Placebo
24 Improve: Integrating Emotion Focused Components Into Psychological Therapy Active, not recruiting NCT02822443 Phase 2
25 Psychological First Aid With Children in a High Risk Group - a Repeated Single Case Design Completed NCT01612104 Phase 1
26 Interpersonal Psychotherapy for Depressed Adolescents and Parents Completed NCT00619411 Phase 1
27 Does an Integrative Neuro-psychotherapy Program Foster the Adjustment in Depressed Stroke Patients? A Randomized Controlled Study. Terminated NCT01039857 Phase 1
28 Effectiveness of Online Systematic Brief Psychodynamic Psychotherapy for Neurotic Disorders: Randomized Controlled Trial Unknown status NCT02257996 Not Applicable
29 Psychological Flexibility and Effectiveness of Psychotherapy Unknown status NCT02291068 Not Applicable
30 Internet-based Cognitive Behavior Therapy for Stress Disorders: a Randomized Trial Unknown status NCT02540317 Not Applicable
31 Neuropattern - Assessment of a Translational Diagnostic Tool for Depression, Adjustment- and Somatoform-disorders Unknown status NCT01062880 Not Applicable
32 Evaluation of the Texas Wellness Incentives and Navigation (WIN) Project Completed NCT02440906 Not Applicable
33 Parent-Augmented Cognitive Behavioral Therapy to Treat Children With Specific Phobias Completed NCT00509951 Not Applicable
34 Veterans Individual Placement and Support Towards Advancing Recovery Completed NCT01817712 Not Applicable
35 Psychotherapy Treatment of Deployment-Related PTSD in Primary Care Settings Completed NCT00974402 Not Applicable
36 Cognitive and Psychosocial Outcome After Mild Traumatic Brain Injury Completed NCT02161172
37 Efficacy of Two Ways of Applying Homework Assignments in the Treatment of Adjustment Disorders Completed NCT02452411 Not Applicable
38 Validation of a Scale of Well-being at Work Completed NCT02905071 Not Applicable
39 Outcome Study of the ReDO Intervention for Women With Stress-related Disorders Completed NCT01234961 Not Applicable
40 Return to Work: Promoting Health and Productivity in Workers With Common Mental Disorders Completed NCT01805583 Not Applicable
41 MINDFUL-PC: Integrating Mindfulness Into the Patient-Centered Medical Home Completed NCT02972203 Not Applicable
42 Registry of Mastectomy for Breast Cancer Risk Reduction Completed NCT00555503
43 Psychiatric Day Hospital Treatment Completed NCT00153959 Not Applicable
44 Couples Coping With Multiple Chronic Medical Conditions Completed NCT01912157 Not Applicable
45 A Randomized Controlled Trial of PCIT-ED for Preschool Depression Completed NCT02076425 Not Applicable
46 Trends in Cohabitation Status, Academic Achievement and Socio-economic Indicators After Mild Traumatic Brain Injury Completed NCT03678077
47 Multidimensional Assessment of Fatigue in Multiple Sclerosis- Observational Study - Ticino Completed NCT02082002
48 An Adjunctive Family Intervention for Individual Posttraumatic Stress Disorder Treatment Recruiting NCT02956434 Not Applicable
49 School Withdrawal in Adolescents Recruiting NCT03904784
50 Effectiveness of a Community - Based Cross-sector Network for the Management of Mental Health Problems and Disorders Associated With Forced Displacement Due to Armed Conflict in the Municipality of Soacha - Cundinamarca Recruiting NCT03839225 Not Applicable

Search NIH Clinical Center for Neurotic Disorder

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: adjustment disorders

Genetic Tests for Neurotic Disorder

Anatomical Context for Neurotic Disorder

MalaCards organs/tissues related to Neurotic Disorder:

42
Heart, Brain, Testes, Prostate, Colon, Whole Blood, Cortex

Publications for Neurotic Disorder

Articles related to Neurotic Disorder:

(show top 50) (show all 1294)
# Title Authors Year
1
The impact of inhaled bronchodilators on bronchopulmonary dysplasia: a nonrandomized comparison from the NEuroSIS trial. ( 30922128 )
2019
2
Neurosis and true dermatosis: a case of ossified pilomatricoma developing within a self-inflicted ulcer. ( 30865412 )
2019
3
"The Neurosis That Has Possessed Us": Political Repression in the Cold War Medical Profession. ( 29718289 )
2018
4
Hallucination in Adolescence-Or, Nora in Nowhereland Between Neurosis and Psychosis. ( 30300083 )
2018
5
Kraepelin's views on obsessive neurosis: a comparison with DSM-5 criteria for obsessive-compulsive disorder. ( 28300946 )
2017
6
Effects of cultured Cordyceps mycelia polysaccharide A on tumor neurosis factor-α induced hepatocyte injury with mitochondrial abnormality. ( 28267517 )
2017
7
Inhaled Glucocorticoids and Pneumonia in Preterm Infants: Post Hoc Results from the NEuroSIS Trial. ( 28456800 )
2017
8
Maldonado, J.L. & Solimano, A.L. (2016). 'Reflections on trauma, symbolization and psychic pain in a case of neurosis and a case of psychosis'. International Journal of Psychoanalysis, 97, 5, 1299-1320. ( 28776649 )
2017
9
Hypochondria as an actual neurosis. ( 28960345 )
2017
10
Treatment of the Opium Neurosis: By Stephen Lett, M.D., Ont., Canada. ( 29067412 )
2017
11
The exchange of monoamines during the experimental neurosis on the background of using of amide "2-hydroxy-n-naphthalen-1-yl-2-(2-oxo-,2-dihydroindol-3-ylidene)". ( 29203736 )
2017
12
Economic Stress and Mental Health: The Relationship Between the Stock Market and Neurotic Disorder Doctor Visits. ( 27017837 )
2016
13
Vallejo-Nágera (1926-1990) and the concept of 'soteric neurosis': a forgotten sketch of hoarding disorder in the obsessive-compulsive spectrum literature. ( 24658218 )
2016
14
Cats on the Couch: The Experimental Production of Animal Neurosis. ( 26903373 )
2016
15
Reflections on trauma, symbolization and psychic pain in a case of neurosis and a case of psychosis. ( 27059446 )
2016
16
Re-conceptualizing Neurosis as a Degree of Egocentricity: Ethical Issues in Psychological Theory. ( 25216966 )
2015
17
Neurosis Meets Psychosis: Case Series from a Tertiary Care Center in South India. ( 26664092 )
2015
18
The Major Mobilization of the Unconscious and the Total Removal of Resistance in Davanloo's Intensive Short-term Dynamic Psychotherapy Part II: Treating the Transference Neurosis. ( 26802424 )
2015
19
Body dysmorphic disorder: Borderline category between neurosis and psychosis. ( 24574566 )
2014
20
It is never too late to treat anxiety neurosis or panic disorder with a serotonin-reuptake inhibitor. ( 25988044 )
2014
21
Dissociative disorders: between neurosis and psychosis. ( 25405051 )
2014
22
Whither the psychosis-neurosis borderline. ( 24436054 )
2014
23
Body dysmorphic disorder: Borderline category between neurosis and psychosis. ( 24459311 )
2013
24
Why nature doesn't turn off neurosis. ( 21409479 )
2013
25
The great neurosis of Dr. Joseph Gerard. ( 23485892 )
2013
26
Is 'depression' the new 'neurosis'? ( 23568154 )
2013
27
Aspects of narcissism and symbiosis, or, essential neurosis of twins. ( 22712590 )
2012
28
Compensation neurosis: a too quickly forgotten concept? ( 22960922 )
2012
29
From sensorimotor inhibition to freudian repression: insights from psychosis applied to neurosis. ( 23162501 )
2012
30
Efficacy of nursing interventions in reducing social and occupational disabilities among patients with neurosis. ( 23923597 )
2012
31
Differential effects of childhood abuse and neglect: mediation by posttraumatic distress in neurotic disorder and negative symptoms in schizophrenia? ( 21295351 )
2011
32
Correspondence (letter to the editor): Obsessive-compulsive neurosis in psychoanalytical terms. ( 22114651 )
2011
33
The fight for 'traumatic neurosis', 1889-1916: Hermann Oppenheim and his opponents in Berlin. ( 22530374 )
2011
34
The Neonatal European Study of Inhaled Steroids (NEUROSIS): an eu-funded international randomised controlled trial in preterm infants. ( 19590247 )
2010
35
'War neurosis' during the Spanish Civil War (1936-39). ( 21877420 )
2010
36
Depressive neurosis treated by acupuncture for regulating the liver--a report of 176 cases. ( 19663089 )
2009
37
Neurosis: aspects of its conceptual development in the nineteenth century. ( 20617639 )
2009
38
Parents of childhood X-linked adrenoleukodystrophy: high risk for depression and neurosis. ( 18430533 )
2008
39
The working alliance and the transference neurosis. 1965. ( 18386657 )
2008
40
Commentary on Greenson's "The working alliance and the transference neurosis". ( 18386658 )
2008
41
Discussion of "The working alliance and the transference neurosis," by Ralph R. Greenson. ( 18386659 )
2008
42
Trauma and traumatic neurosis: Freud's concepts revisited. ( 18405287 )
2008
43
Forty cases of gastrointestinal neurosis treated by acupunture. ( 18416077 )
2008
44
Clinical observation on post-stroke anxiety neurosis treated by acupuncture. ( 19004200 )
2008
45
Reflex neurosis (NEAD). ( 19771316 )
2008
46
Actual neurosis as the underlying psychic structure of panic disorder, somatization, and somatoform disorder: an integration of Freudian and attachment perspectives. ( 18085013 )
2007
47
The concept of neurosis in a cross-cultural perspective. ( 17143082 )
2007
48
Point prevalence of neurosis in the Lundby Study 1947-1997. ( 17365787 )
2007
49
On the adolescent neurosis. ( 17503625 )
2007
50
War neurosis, adjustment problems in veterans, and an ill nation: The disciplinary project of American psychiatry during and after World War II. ( 18175466 )
2007

Variations for Neurotic Disorder

Expression for Neurotic Disorder

Search GEO for disease gene expression data for Neurotic Disorder.

Pathways for Neurotic Disorder

Pathways related to Neurotic Disorder according to KEGG:

38
# Name Kegg Source Accession
1 Neuroactive ligand-receptor interaction hsa04080
2 Dopaminergic synapse hsa04728

GO Terms for Neurotic Disorder

Molecular functions related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 CAMP LY96

Sources for Neurotic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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