MCID: NRT001
MIFTS: 41

Neurotic Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Neurotic Disorder

MalaCards integrated aliases for Neurotic Disorder:

Name: Neurotic Disorder 12 15
Adjustment Disorders 44 73
Reactive Depression 12 73
Neurotic Disorders 44 73
Neurosis 12 37
Neurotic Depression Reactive Type 12
Neurotic Depressive State 12
Depression, Neurotic 73
Depressive Neurosis 12
Neurotic Depression 12
Depressive Disorder 73
Psychoneurosis 12

Classifications:



Summaries for Neurotic Disorder

Disease Ontology : 12 An anxiety disorder that involves discress but neither delusions nor hallucinations.

MalaCards based summary : Neurotic Disorder, also known as adjustment disorders, is related to adjustment disorder and post-traumatic stress disorder, and has symptoms including depressed reaction and depressed - symptom. An important gene associated with Neurotic Disorder is MFSD8 (Major Facilitator Superfamily Domain Containing 8), and among its related pathways/superpathways are Neuroactive ligand-receptor interaction and Dopaminergic synapse. The drugs Citalopram and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, prostate and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Neurosis is a class of functional mental disorders involving chronic distress but neither delusions nor... more...

Related Diseases for Neurotic Disorder

Diseases related to Neurotic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 adjustment disorder 12.6
2 post-traumatic stress disorder 10.4
3 endogenous depression 10.0
4 depression 10.0
5 pellagra 10.0
6 dissociative disorder 10.0
7 miller-dieker lissencephaly syndrome 9.8 GPX4 LY96
8 depersonalization/derealization disorder 9.8
9 schizophrenia 9.8
10 anxiety 9.8
11 generalized anxiety disorder 9.8
12 premenstrual tension 9.7 CAMP LIPN

Graphical network of the top 20 diseases related to Neurotic Disorder:



Diseases related to Neurotic Disorder

Symptoms & Phenotypes for Neurotic Disorder

UMLS symptoms related to Neurotic Disorder:


depressed reaction, depressed - symptom

GenomeRNAi Phenotypes related to Neurotic Disorder according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.5 SLC22A12
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.5 ATP6V0D2 GPX4 SLC22A12
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.5 GPX4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.5 SLC22A12
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.5 ATP6V0D2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.5 ATP6V0D2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.5 SLC22A12
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.5 SLC22A12
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.5 ATP6V0D2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.5 ATP6V0D2 SLC22A12
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.5 SLC22A12
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.5 ATP6V0D2

MGI Mouse Phenotypes related to Neurotic Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 ATP6V0D2 CAMP LY96 MFSD8 PCSK5 SLC22A12
2 nervous system MP:0003631 9.17 GABRA6 GPX4 HTR1A MFSD8 PCSK5 SLC22A12

Drugs & Therapeutics for Neurotic Disorder

Drugs for Neurotic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
2
Benzocaine Approved, Investigational Phase 4,Not Applicable 1994-09-7, 94-09-7 2337
3 tannic acid Approved, Nutraceutical Phase 4,Not Applicable
4 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Not Applicable
5 Cholinergic Agents Phase 4,Phase 2
6 Muscarinic Antagonists Phase 4,Phase 2
7 Cholinergic Antagonists Phase 4,Phase 2
8 Serotonin Agents Phase 4,Phase 3,Phase 2
9 Serotonin Uptake Inhibitors Phase 4,Phase 2
10 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
11 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
12 Parasympatholytics Phase 4,Phase 2
13 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
14 Antidepressive Agents Phase 4,Phase 3,Phase 2
15 Antidepressive Agents, Second-Generation Phase 4,Phase 2
16 Antiparkinson Agents Phase 4,Phase 2
17 Autonomic Agents Phase 4,Phase 3,Phase 2
18
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 50-67-9 5202
19
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
20
Budesonide Approved Phase 3 51333-22-3 63006 5281004
21
Norepinephrine Approved Phase 3 51-41-2 439260
22
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
23
Pregabalin Approved, Illicit, Investigational Phase 3 148553-50-8 5486971
24
Ethanol Approved Phase 3 64-17-5 702
25
Dronabinol Approved, Illicit Phase 3 1972-08-3 16078
26
Peppermint oil Approved, Investigational Phase 3 8006-90-4
27
Propranolol Approved, Investigational Phase 2, Phase 3 525-66-6 4946
28
Peppermint Approved, Nutraceutical Phase 3
29 Quetiapine Fumarate Phase 3 111974-72-2
30 Analgesics Phase 3,Phase 2
31 calcium channel blockers Phase 3,Phase 2
32 glucocorticoids Phase 3
33 Respiratory System Agents Phase 3
34 Central Nervous System Depressants Phase 3,Phase 2
35 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
36 Serotonin Antagonists Phase 3
37 Hallucinogens Phase 3
38 Analgesics, Non-Narcotic Phase 3
39 Hormone Antagonists Phase 3
40 Tranquilizing Agents Phase 3
41 Hormones Phase 3
42 Anti-Anxiety Agents Phase 3
43 Dopamine Agents Phase 3
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
45 Dopamine Antagonists Phase 3
46 Anti-Asthmatic Agents Phase 3
47 Duloxetine Hydrochloride Phase 3
48 Anticonvulsants Phase 3,Phase 2
49 Anti-Inflammatory Agents Phase 3
50 Antipsychotic Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 64)
# Name Status NCT ID Phase Drugs
1 Cognitive-Behavioral Therapy and Escitalopram for Generalized Anxiety Disorder(GAD) Completed NCT00219349 Phase 4 escitalopram
2 Veterans Individual Placement and Support Towards Advancing Recovery Completed NCT01817712 Phase 4
3 Clinical Trial of Tenoten® in the Treatment of Anxiety in Patients With Somatoform, Stress-related and Other Neurotic Disorders Recruiting NCT03036293 Phase 4 Tenoten;Placebo
4 A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder Unknown status NCT00978484 Phase 3
5 Efficacy and Safety of Inhaled Budesonide in Very Preterm Infants at Risk for Bronchopulmonary Dysplasia Completed NCT01035190 Phase 3 Budesonide
6 A Study in Pediatric Participants With Generalized Anxiety Disorder Completed NCT01226511 Phase 3 Duloxetine;Placebo
7 Determine Long-Term Safety and Tolerability of Pregabalin in Patients With Anxiety Disorders. Completed NCT00150449 Phase 3 Pregabalin
8 Generalized Anxiety Disorder Adjunct Study Completed NCT00534599 Phase 3 Placebo;quetiapine fumarate XR
9 An Investigation of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosis Patients Completed NCT01610700 Phase 3 GW-1000-02;Placebo
10 A Study of Sativex® for Relief of Peripheral Neuropathic Pain Associated With Allodynia. Completed NCT00711880 Phase 3 Sativex®;Placebo
11 An Study to Investigate the Efficacy of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosis Completed NCT01610713 Phase 3 GW-1000-02
12 Clinical Trial of Safety and Efficiency of Afalaza in Patients With Symptoms of Benign Prostatic Hyperplasia and Risk of Progression Completed NCT01716104 Phase 3 Afalaza;Placebo
13 Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone. Completed NCT00399698 Phase 3 Risperdal
14 The Trauma of Betrayal: Treating Adjustment Disorder With Reconsolidation Blockade Under Propranolol Active, not recruiting NCT03151681 Phase 2, Phase 3 Propranolol Pill
15 An Open-Label Study Of Lamictal In Neurotic Excoriation Completed NCT00269594 Phase 2 Lamictal (lamotrigine)
16 Fast-Fail Trials in Mood and Anxiety Spectrum Disorders; Kappa Opioid Receptor Phase 2a Completed NCT02218736 Phase 2 CERC-501;placebo
17 Nexalin Therapy for the Treatment of Depressive Symptoms Completed NCT00774813 Phase 2 placebo device and Citalopram
18 Efficacy and Safety of S 47445 Versus Placebo as Adjunctive Treatment in Depressed Patients Not Fully Recovered From Depressive Symptoms With a Current Antidepressant Treatment Completed NCT02805439 Phase 2 S47445 15mg;S47445 50mg;Placebo
19 Depression Prevention for Pregnant Women on Public Assistance Completed NCT00601757 Phase 2
20 The Efficacy of Parent Involvement in the Treatment of Adolescent Depression Completed NCT00883519 Phase 1, Phase 2
21 Group Interpersonal Psychotherapy for Depressed Adolescents in School-based Clinics Completed NCT00270244 Phase 2
22 Improve: Integrating Emotion Focused Components Into Psychological Therapy Recruiting NCT02822443 Phase 2
23 Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators Recruiting NCT03152175 Phase 2 Propranolol Hydrochloride;Placebo
24 Psychological First Aid With Children in a High Risk Group - a Repeated Single Case Design Completed NCT01612104 Phase 1
25 Interpersonal Psychotherapy for Depressed Adolescents and Parents Completed NCT00619411 Phase 1
26 Does an Integrative Neuro-psychotherapy Program Foster the Adjustment in Depressed Stroke Patients? A Randomized Controlled Study. Terminated NCT01039857 Phase 1
27 Effectiveness of Online Systematic Brief Psychodynamic Psychotherapy for Neurotic Disorders: Randomized Controlled Trial Unknown status NCT02257996 Not Applicable
28 Psychological Flexibility and Effectiveness of Psychotherapy Unknown status NCT02291068 Not Applicable
29 Neuropattern - Assessment of a Translational Diagnostic Tool for Depression, Adjustment- and Somatoform-disorders Unknown status NCT01062880 Not Applicable
30 Evaluation of the Texas Wellness Incentives and Navigation (WIN) Project Completed NCT02440906 Not Applicable
31 Parent-Augmented Cognitive Behavioral Therapy to Treat Children With Specific Phobias Completed NCT00509951 Not Applicable
32 Psychotherapy Treatment of Deployment-Related PTSD in Primary Care Settings Completed NCT00974402 Not Applicable
33 Cognitive and Psychosocial Outcome After Mild Traumatic Brain Injury Completed NCT02161172
34 Efficacy of Two Ways of Applying Homework Assignments in the Treatment of Adjustment Disorders Completed NCT02452411 Not Applicable
35 Outcome Study of the ReDO Intervention for Women With Stress-related Disorders Completed NCT01234961 Not Applicable
36 Return to Work: Promoting Health and Productivity in Workers With Common Mental Disorders Completed NCT01805583 Not Applicable
37 Registry of Mastectomy for Breast Cancer Risk Reduction Completed NCT00555503
38 Psychiatric Day Hospital Treatment Completed NCT00153959 Not Applicable
39 A Randomized Controlled Trial of PCIT-ED for Preschool Depression Completed NCT02076425 Not Applicable
40 An Adjunctive Family Intervention for Individual Posttraumatic Stress Disorder Treatment Recruiting NCT02956434 Not Applicable
41 Neurobiological Effects of Work-related Adjustment Disorder Recruiting NCT03334045
42 Development and Validation of an Online Treatment Program for Adjustment Disorders Recruiting NCT02758418 Not Applicable
43 Internet-based Self-help for Negative Life Events Recruiting NCT03379155 Not Applicable
44 Integrated Mental Health Care and Vocational Rehabilitation to Individuals on Sick Leave Due to Stress Disorders Recruiting NCT02885519 Not Applicable
45 Effectiveness of Two Stress Management Programs in Adaptation Disorder With Anxiety (ADA) Recruiting NCT02621775 Not Applicable
46 Validation of a Scale of Well-being at Work Recruiting NCT02905071 Not Applicable
47 Efficacy of Two Internet Delivered Intervention Programs for Depression: Behavioral Activation vs Physical Activity Recruiting NCT02369393 Not Applicable
48 A Problem Solving Based Intervention for Facilitating Return-to-work Among People Suffering From Common Mental Disorders Recruiting NCT03346395 Not Applicable
49 Effects of Mindfulness Based Cognitive Therapy on Emotional Processing Recruiting NCT03358056 Not Applicable
50 Open Clinical Trial of CBT-based Multiprofessional Rehabilitation for Exhaustion Disorder Recruiting NCT03360136 Not Applicable

Search NIH Clinical Center for Neurotic Disorder

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: adjustment disorders

Genetic Tests for Neurotic Disorder

Anatomical Context for Neurotic Disorder

MalaCards organs/tissues related to Neurotic Disorder:

41
Brain, Prostate, Bone, Bone Marrow

Publications for Neurotic Disorder

Articles related to Neurotic Disorder:

(show top 50) (show all 160)
# Title Authors Year
1
Adjustment disorder and type-specific cancer incidence: a Danish cohort study. ( 29688114 )
2018
2
Adjustment disorder: A diagnosis whose time has come. ( 29107817 )
2018
3
An internet-based intervention for adjustment disorder (TAO): study protocol for a randomized controlled trial. ( 29855281 )
2018
4
Altered autonomic reactivity in Korean military soldiers with adjustment disorder. ( 29353770 )
2018
5
A Brief Measure of the International Classification of Diseases-11 Adjustment Disorder: Investigation of Psychometric Properties in an Adult Help-Seeking Sample. ( 29301130 )
2018
6
Latent class analysis differentiation of adjustment disorder and demoralization, more severe depressive and anxiety disorders, and somatic symptoms in patients with cancer. ( 29761579 )
2018
7
A Systematic Review of Psychological and Pharmacological Treatments for Adjustment Disorder in Adults. ( 29958336 )
2018
8
Screening of adjustment disorder: Scale based on the ICD-11 and the Adjustment Disorder New Module. ( 29803077 )
2018
9
An empirical assessment of adjustment disorder as proposed for ICD-11 in a general population sample of Israel. ( 29426030 )
2018
10
Efficacy of synchronous telepsychology interventions for people with anxiety, depression, posttraumatic stress disorder, and adjustment disorder: A rapid evidence assessment. ( 29809025 )
2018
11
Adjustment disorder: current perspectives. ( 29416339 )
2018
12
Evoked Death-Related Thoughts in the Aftermath of Terror Attack: The Associations Between Mortality Salience Effect and Adjustment Disorder. ( 29271826 )
2018
13
The role of therapist support on effectiveness of an internet-based modular self-help intervention for adjustment disorder: a randomized controlled trial. ( 28984157 )
2018
14
A socio-interpersonal approach to adjustment disorder: the example of involuntary job loss. ( 29410777 )
2018
15
Adjustment disorder: Prevalence, sociodemographic risk factors, and its subtypes in outpatient psychiatric clinic. ( 28784404 )
2017
16
A scoping review of ICD-11 adjustment disorder research. ( 29372011 )
2017
17
Internet-Based Self-Help Intervention for ICD-11 Adjustment Disorder: Preliminary Findings. ( 29124500 )
2017
18
Is adjustment disorder unidimensional or multidimensional? Implications for ICD-11. ( 28990345 )
2017
19
Do previous experience and geographic proximity matter? Possible predictors for diagnosing Adjustment disorder vs. PTSD. ( 28951140 )
2017
20
Psychopathological characteristics of adjustment disorder among outpatients with and without work related stress. ( 29916595 )
2017
21
Nail-extracting behaviour as an unusual manifestation of adjustment disorder, confused with onychotillomania. ( 29206306 )
2017
22
Exploratory examination of the utility of demoralization as a diagnostic specifier for adjustment disorder and major depression. ( 28622810 )
2017
23
Integrated mental health care and vocational rehabilitation to improve return to work rates for people on sick leave because of exhaustion disorder, adjustment disorder, and distress (the Danish IBBIS trial): study protocol for a randomized controlled trial. ( 29197404 )
2017
24
Efficacy of Seren@ctif, a Computer-Based Stress Management Program for Patients With Adjustment Disorder With Anxiety: Protocol for a Controlled Trial. ( 28970192 )
2017
25
Abnormal regional homogeneity and functional connectivity in adjustment disorder of new recruits: a resting-state fMRI study. ( 28144895 )
2017
26
Prevalence and predictors of post-stroke mood disorders: A meta-analysis and meta-regression of depression, anxiety and adjustment disorder. ( 28807138 )
2017
27
The Adjustment Disorder--New Module 20 as a Screening Instrument: Cluster Analysis and Cut-off Values. ( 27651082 )
2016
28
Self-help interventions for adjustment disorder problems: a randomized waiting-list controlled study in a sample of burglary victims. ( 27299909 )
2016
29
Measuring the ICD-11 adjustment disorder concept: Validity and sensitivity to change of the Adjustment Disorder - New Module questionnaire in a clinical intervention study. ( 27862575 )
2016
30
Adjustment disorder and risk of Parkinson's disease. ( 26756302 )
2016
31
Decreased medial frontal gyrus in patients with adjustment disorder. ( 26630395 )
2016
32
A longitudinal study on anxiety, depressive and adjustment disorder, suicide ideation and symptoms of emotional distress in patients with cancer undergoing radiotherapy. ( 27411747 )
2016
33
Adjustment disorder: Empirical study of a new diagnostic concept for ICD-11 in the general population in Lithuania. ( 27837668 )
2016
34
Psychological defense mechanisms among individuals with SCI with adjustment disorder. ( 27077569 )
2016
35
Economic Stress and Mental Health: The Relationship Between the Stock Market and Neurotic Disorder Doctor Visits. ( 27017837 )
2016
36
The bimodal P300 oddball component is decreased in patients with an adjustment disorder: An event-related potentials study. ( 27521621 )
2016
37
Demographic variables, clinical aspects, and medicolegal implications in a population of patients with adjustment disorder. ( 27099504 )
2016
38
Internet-based modular program BADI for adjustment disorder: protocol of a randomized controlled trial. ( 27456085 )
2016
39
A Longitudinal Study of Adjustment Disorder After Trauma Exposure. ( 27771970 )
2016
40
Adjustment Disorder as an Occupational Disease: Our Experience in Italy. ( 26772598 )
2016
41
Suicidal behaviours in adjustment disorder and depressive episode. ( 25553405 )
2015
42
Suicidal Tendency Among Adolescents With Adjustment Disorder. ( 26088824 )
2015
43
Validity of reaction to severe stress and adjustment disorder diagnoses in the Danish Psychiatric Central Research Registry. ( 25870515 )
2015
44
Adjustment Disorder in Pregnant Women: Prevalence and Correlates in a Northern Mexican City. ( 26346070 )
2015
45
Etifoxine versus alprazolam for the treatment of adjustment disorder with anxiety: a randomized controlled trial. ( 25620535 )
2015
46
STRESSORS, SYMPTOM PROFILE, AND PREDICTORS OF ADJUSTMENT DISORDER IN CANCER PATIENTS. RESULTS FROM AN EPIDEMIOLOGICAL STUDY WITH THE COMPOSITE INTERNATIONAL DIAGNOSTIC INTERVIEW, ADAPTATION FOR ONCOLOGY (CIDI-O). ( 26474266 )
2015
47
Subarachnoid hemorrhage misdiagnosed as adjustment disorder. ( 25806556 )
2015
48
Adjustment disorder as proposed for ICD-11: Dimensionality and symptom differentiation. ( 26272020 )
2015
49
Suicidal tendency in a sample of adolescent outpatients with adjustment disorder: gender differences. ( 24889338 )
2014
50
Development and validation of the Diagnostic Interview Adjustment Disorder (DIAD). ( 24478059 )
2014

Variations for Neurotic Disorder

Expression for Neurotic Disorder

Search GEO for disease gene expression data for Neurotic Disorder.

Pathways for Neurotic Disorder

Pathways related to Neurotic Disorder according to KEGG:

37
# Name Kegg Source Accession
1 Neuroactive ligand-receptor interaction hsa04080
2 Dopaminergic synapse hsa04728

GO Terms for Neurotic Disorder

Sources for Neurotic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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