MCID: NRT001
MIFTS: 53

Neurotic Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Neurotic Disorder

MalaCards integrated aliases for Neurotic Disorder:

Name: Neurotic Disorder 12 15 17
Adjustment Disorders 43 71 32
Neurosis 12 36 15
Reactive Depression 12 71
Neurotic Disorders 43 71
Neurotic Depression Reactive Type 12
Neurotic Depressive State 12
Depression, Neurotic 71
Depressive Neurosis 12
Neurotic Depression 12
Depressive Disorder 71
Psychoneurosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4964
KEGG 36 H01671
SNOMED-CT 67 111475002 87414006
UMLS 71 C0001546 C0011579 C0011581 more

Summaries for Neurotic Disorder

KEGG : 36 Neurosis is a class of functional mental disorders involving distress but neither delusions nor hallucinations, whereby behavior is not outside socially acceptable norms. The state of research on neurosis has moved towards looking at biological and genetic substrates or mechanisms underlying neurosis. The recent literature shows acceptance of common mental disorders such as Generalized anxiety disorder (GAD), Panic disorder (PD), and Obsessive-compulsive disorder (OCD), across cultures replacing neurotic disorder. Usage of the diagnosis of neurosis has been decreased, and replaced by newer categories in the current popular classificatory systems. In the International Classification of Diseases (ICD-10), all disorders regarded as neurosis remained together but under the division of rubric 'neurotic, stress-related and somatoform disorders'. In the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), neurosis has been eliminated as a category.

MalaCards based summary : Neurotic Disorder, also known as adjustment disorders, is related to somatization disorder and obsessive-compulsive personality disorder, and has symptoms including depressed reaction and depressed - symptom. An important gene associated with Neurotic Disorder is MFSD8 (Major Facilitator Superfamily Domain Containing 8), and among its related pathways/superpathways are Neuroactive ligand-receptor interaction and Dopaminergic synapse. The drugs Valsartan and Ropinirole have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are behavior/neurological and cardiovascular system

Disease Ontology : 12 An anxiety disorder that involves discress but neither delusions nor hallucinations.

Wikipedia : 74 Neurosis is a class of functional mental disorders involving chronic distress but neither delusions nor... more...

Related Diseases for Neurotic Disorder

Diseases related to Neurotic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 292)
# Related Disease Score Top Affiliating Genes
1 somatization disorder 30.3 SLC6A4 HTR2A FLNA
2 obsessive-compulsive personality disorder 30.3 SLC6A4 HTR2A
3 body dysmorphic disorder 30.2 SLC6A4 MAOA HTR2A
4 dissociative disorder 30.1 SLC6A4 HTR2A BDNF
5 delusional disorder 29.9 TH HTR2A HTR1A
6 tic disorder 29.7 SLC6A4 MAOA HTR2A HTR1A
7 antisocial personality disorder 29.5 SLC6A4 MAOA HTR2A
8 dysthymic disorder 29.5 SLC6A4 MAOA HTR2A HTR1A BDNF
9 panic disorder 29.5 SLC6A4 MAOA HTR2A HTR1A BDNF
10 eating disorder 29.5 SLC6A4 HTR2A BDNF
11 diarrhea 29.5 TNF SLC6A4 HTR1A FLNA
12 hypochondriasis 29.4 SLC6A4 HTR2A HTR1A BDNF
13 social phobia 29.3 SLC6A4 MAOA HTR1A BDNF
14 generalized anxiety disorder 29.2 SLC6A4 MAOA HTR2A HTR1A BDNF
15 somatoform disorder 29.2 TNF SLC6A4 BDNF
16 personality disorder 29.2 TH SLC6A4 MAOA HTR2A HTR1A BDNF
17 alcohol use disorder 29.2 SLC6A4 HTR2A HTR1A BDNF
18 adjustment disorder 29.1 SLC6A4 HTR2A HTR1A FLNA BDNF
19 depression 29.0 SLC6A4 MAOA HTR2A HTR1A BDNF
20 post-traumatic stress disorder 29.0 SLC6A4 MAOA HTR2A HTR1A BDNF
21 chronic fatigue syndrome 29.0 TNF SLC6A4 MAOA HTR2A HTR1A
22 substance abuse 29.0 SLC6A4 MAOA HTR2A HTR1A BDNF
23 atypical depressive disorder 28.9 SLC6A4 MAOA HTR2A HTR1A BDNF
24 schizoaffective disorder 28.8 SLC6A4 HTR2A HTR1A BDNF
25 agoraphobia 28.8 SLC6A4 MAOA HTR2A HTR1A BDNF
26 anorexia nervosa 28.8 SLC6A4 MAOA HTR2A HTR1A BDNF
27 obsessive-compulsive disorder 28.5 TNF SLC6A4 MAOA HTR2A HTR1A BDNF
28 borderline personality disorder 28.5 TH SLC6A4 MAOA HTR2A HTR1A BDNF
29 migraine with or without aura 1 28.5 TNF SLC6A4 MAOA HTR2A HTR1A BDNF
30 mood disorder 28.3 TH SLC6A4 MAOA HTR2A HTR1A BDNF
31 psychotic disorder 28.3 TH SLC6A4 MAOA HTR2A HTR1A BDNF
32 endogenous depression 28.3 TH SLC6A4 MAOA HTR2A HTR1A BDNF
33 narcolepsy 28.3 TNF SLC6A4 MAOA HTR2A BDNF
34 fibromyalgia 28.2 TNF SLC6A4 HTR2A HTR1A BDNF
35 alcohol dependence 28.2 TNF TH SLC6A4 MAOA HTR2A HTR1A
36 major depressive disorder 28.2 TNF SLC6A4 MAOA HTR2A HTR1A BDNF
37 paranoid schizophrenia 28.1 TNF SLC6A4 MAOA HTR2A HTR1A BDNF
38 mental depression 28.1 TNF SLC6A4 MAOA HTR2A HTR1A BDNF
39 dementia 28.1 TNF TH MFSD8 HTR2A HTR1A BDNF
40 anxiety 27.9 TNF TH SLC6A4 MAOA HTR2A HTR1A
41 sleep disorder 27.9 TNF TH SLC6A4 HTR2A HTR1A BDNF
42 schizophrenia 27.8 TNF TH SLC6A4 MAOA HTR2A HTR1A
43 melancholia 27.7 TNF SLC6A4 SEMA3F-AS1 MAOA HTR2A HTR1A
44 disease of mental health 27.6 TNF TH SLC6A4 MAOA HTR2A HTR1A
45 bipolar disorder 27.5 TNF TH SLC6A4 MAOA HTR2A HTR1A
46 autism 27.5 TNF TH SLC6A4 MAOA HTR2A HTR1A
47 panic disorder 1 11.7
48 conversion disorder 11.7
49 orthostatic intolerance 11.5
50 wilson disease 11.3

Graphical network of the top 20 diseases related to Neurotic Disorder:



Diseases related to Neurotic Disorder

Symptoms & Phenotypes for Neurotic Disorder

UMLS symptoms related to Neurotic Disorder:


depressed reaction, depressed - symptom

MGI Mouse Phenotypes related to Neurotic Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 BDNF FLNA GAN GPX4 HTR1A HTR2A
2 cardiovascular system MP:0005385 9.32 DCAF8 FLNA GPX4 HTR1A MAOA MFSD8

Drugs & Therapeutics for Neurotic Disorder

Drugs for Neurotic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 597)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
2
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 497540 5095
3
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
4
Oxcarbazepine Approved Phase 4 28721-07-5 34312
5
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
6
Brexpiprazole Approved, Investigational Phase 4 913611-97-9 11978813
7
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
8
Amitriptyline Approved Phase 4 50-48-6 2160
9
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
10
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
11
Propranolol Approved, Investigational Phase 4 525-66-6 4946
12
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
13
Desipramine Approved, Investigational Phase 4 50-47-5 2995
14
Testosterone enanthate Approved Phase 4 315-37-7 9416
15
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
16
Methyltestosterone Approved Phase 4 58-18-4 6010
17
Moclobemide Approved, Investigational Phase 4 71320-77-9 4235
18
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
19
Memantine Approved, Investigational Phase 4 19982-08-2 4054
20
Curcumin Approved, Experimental, Investigational Phase 4 458-37-7 969516
21
Ziprasidone Approved Phase 4 146939-27-7 60854
22
Nortriptyline Approved Phase 4 72-69-5 4543
23
Iloperidone Approved Phase 4 133454-47-4 71360
24
Terazosin Approved Phase 4 63590-64-7 5401
25
Zolpidem Approved Phase 4 82626-48-0 5732
26
Calcium carbonate Approved, Investigational Phase 4 471-34-1
27
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
28
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
29
Methohexital Approved Phase 4 151-83-7 9034
30
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
31
Methadone Approved Phase 4 76-99-3 4095
32
Ribavirin Approved Phase 4 36791-04-5 37542
33
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
34
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
35
Doxepin Approved, Investigational Phase 4 1668-19-5 667477 667468
36
Protriptyline Approved Phase 4 438-60-8 4976
37
Trimipramine Approved Phase 4 739-71-9 5584 4055
38
Topiramate Approved Phase 4 97240-79-4 5284627
39
Isocarboxazid Approved Phase 4 59-63-2 3759
40
Maprotiline Approved, Investigational Phase 4 10262-69-8 4011
41
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
42
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
43
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
44
Donepezil Approved Phase 4 120014-06-4 3152
45
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
46
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
47
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
48
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
49
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
50
Metyrapone Approved, Investigational Phase 4 54-36-4 4174

Interventional clinical trials:

(show top 50) (show all 4224)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study of Escitalopram Treatment and Biomarkers in Major Depressive Disorder Unknown status NCT01997580 Phase 4 escitalopram
2 The Effect and Reliability of Escitalopram in the Treatment of Adolescents With Major Depressive Disorder or Anxiety Disorders Unknown status NCT03122158 Phase 4 Escitalopram
3 Role of Inflammation Factors and Insulin Resistance in the Pathophysiology and Treatment Response of Major Depressive Disorder Unknown status NCT01699490 Phase 4 Fluoxetine + Valsartan;Fluoxetine + Placebo
4 Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disorder Unknown status NCT02294305 Phase 4 Vortioxetine;Placebo
5 Pharmacogenomics Studies of Antidepressants Unknown status NCT01204086 Phase 4 Venlafaxine;Fluoxetine
6 Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder Unknown status NCT02051413 Phase 4 Venlafaxine extended release
7 Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder Unknown status NCT01460212 Phase 4 SSRI antidepressants
8 Clinical Trial of the Use of Ketamine in Treatment Resistant Depression Unknown status NCT02610712 Phase 4 Ketamine
9 Randomized,Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder Unknown status NCT02273154 Phase 4 Buspirone;Paroxetine
10 Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression Unknown status NCT00291239 Phase 4
11 Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder Unknown status NCT00442481 Phase 4 Escitalopram
12 Effect of Escitalopram vs. Reboxetine on Somatic and Visceral Sensitivity of Patients With Major Depressive Disorder: a Randomized, Double Blind Clinical Trial Unknown status NCT00209807 Phase 4 escitalopram;Reboxetine
13 A Dimensional Approach to Evaluate Reward Processing in Major Depressive Disorder Before and After Treatment With Desvenlafaxine Unknown status NCT02859103 Phase 4 Desvenlafaxine
14 Turgut Ozal Medical Center Department of Anesthesiology and Reanimation Unknown status NCT02267980 Phase 4 Sevoflurane;Ketamine;Saline
15 Exploring Alterations of Central Autonomic Modulation in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
16 Inflammatory Markers and Cognitive Function in Major Depression:a Pilot Study Unknown status NCT01391221 Phase 4 Duloxetine
17 Duloxetine for the Treatment of Major Depression in Midlife Women: Effects on Brain Structure and Functioning, Mood, and Quality of Life Unknown status NCT00889369 Phase 4 Duloxetine
18 Hyperventilation and ECT Seizure Duration: Effects on Cerebral Oxygen Saturation, and Therapeutic Outcome With Comparisons Between Etomidate and Ketamine in Patients With Major Depressive Disorder Unknown status NCT02924090 Phase 4 Etomidate;Ketamine
19 Algorithm Guided Treatment Strategies for Major Depressive Disorder Unknown status NCT01764867 Phase 4 Escitalopram;Mirtazapine;Fluoxetine;Citalopram;Escitalopram;Paroxetine;Sertraline;Fluvoxamine;Venlafaxine;Duloxetine;Mirtazapine;Bupropion;Trazodone
20 A Randomised Trial Investigating the Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder. Unknown status NCT01483053 Phase 4 Agomelatine;Escitalopram
21 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar I and II Depression. Unknown status NCT00335205 Phase 4 ropinirole
22 Escitalopram Treatment of Major Depression in Diabetes Mellitus: An Open Label Unknown status NCT00650897 Phase 4 Escitalopram
23 White Matter Structure and Response to Treatment With Antidepressants: a Study of Desvenlafaxine in Major Depression. A Pilot Study Unknown status NCT01492621 Phase 4 Desvenlafaxine
24 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
25 Evaluation of the Efficacy of Repetitive Transcranial Magnetic Stimulation on Cognitive, Anxiety and Depressive Symptoms in Patients Diagnosed With Major Depressive Disorder Unknown status NCT02213016 Phase 4
26 A Randomized Controlled Study Comparing Fluoxetine With Bupropion for Impulsivity and Suicidality in Patients With Major Depressive Disorder and Comorbid Alcoholism (Abuse or Dependence) Unknown status NCT00449007 Phase 4 fluoxetine;bupropion
27 A Comparative Trial of TMS Approaches to Treating Depression Unknown status NCT01906905 Phase 4
28 THE AIUNI - Integral Assessment in Unipolar Depression Unknown status NCT02268487 Phase 4 Sertraline
29 Sequence Towards Remission in Depression Unknown status NCT01628783 Phase 4 escitalopram 10 mg;Placebo
30 Exploratory Study to Assess the Efficacy of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer’s Disease, Vascular Dementia and Mixed Vascular and Alzheimer’s Dementia Unknown status NCT00229333 Phase 4 Escitalopram
31 Behandlung Von Leichten Und Unterschwelligen Depressionen. Eine Randomisierte, Kontrollierte Studie Zum Wirksamkeitsnachweis Eines Serotonin-Wiederaufnahme-Hemmers (SSRI), Einer Kognitiven Verhaltenstherapie Und Einer Freien Therapiewahl ("Treatment of Mild and Subthreshold Depressive Disorders". A Randomized, Controlled Trial on the Efficacy of a Serotonin-Reuptake-Inhibitor (SSRI), a Cognitive-Behavioral Therapy and of Free Choice Between SSRI and CBT") Unknown status NCT00226642 Phase 4 Sertralin;Placebo
32 Brain Mechanisms and Targeting Insomnia in Major Depression Unknown status NCT00628914 Phase 4 escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
33 Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy - a Monocentric, Double-Blind, Placebo-Controlled Trial Unknown status NCT00150839 Phase 4 Mirtazapine;Venlafaxine
34 Antidepressant Treatments During Pregnancy and Lactation: Prediction of Drug Exposure Through Breastfeeding and Evaluation of Drug Effect on the Neonatal Adaptation and the Development of the Young Child Unknown status NCT01796132 Phase 4 SSRI/SNRI
35 Neurochemical,Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder Unknown status NCT02346682 Phase 4 venlafaxine
36 Clinical Psychopharmacology Division Institute of Mental Health, Peking University Unknown status NCT03148509 Phase 4 risperidone;aripiprazole;bupropion
37 Integrated Smoking Cessation Treatment for Smokers With Serious Mental Illness Unknown status NCT02845440 Phase 4
38 TMSFOS: Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression Unknown status NCT02042573 Phase 4 SSRI (SEROPLEX ou ZOLOFT)
39 An Exploratory Randomized Open Comparison of Oxtellar XR® vs Oxcarbazepine IR (Trileptal®) for the Treatment of Bipolar Depression Unknown status NCT03567681 Phase 4 Extended release oxcarbazepine vs Immediate release oxcarbazepine
40 Treatment Prediction in Adolescent and Adult Depression Unknown status NCT00106197 Phase 4 Bupropion
41 A Double-Blind, Placebo-Controlled Study of Escitalopram in the Prevention of Depression in Patients With Acute Coronary Syndrome Unknown status NCT00140257 Phase 4 Escitalopram
42 A Double-Blind, Placebo-Controlled, Enriched Enrollment Randomized Withdrawal Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
43 a Randomized, Double Blind, Placebo-controlled, Multicenter Clinical Trial of Efficacy and Safety of Shu Gan yi Yang Capsule in the Treatment of Depression Associated With Erectile Dysfunction (Stagnation of Liver qi and Kidney Deficiency) Unknown status NCT03290313 Phase 4 shu gan yi yang capsule;shu gan yi yang capsule simulation agent
44 Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy Unknown status NCT02579642 Phase 4 Ketamine;Placebo
45 Prediction of Individual Treatment Response Based on Brain Changes at the Early Phase of Antidepressant Treatment in Major Depressive Disorder Using Machine Learning Classification Analysis Unknown status NCT02330679 Phase 4 Desvenlafaxine;Placebo
46 A Randomized Controlled Trial of Antidepressant Maintenance for Major Depression Following Mild Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
47 Collaborative Care for Depressed Elders in China Unknown status NCT01287494 Phase 4 Sertraline
48 A Multicenter, Double Blind Trial to Compare the Efficacy and Safety of Escitalopram With Placebo in Patients With Acute Stroke for the Prevention of Poststroke Depression and Related Symptoms (Emotional Incontinence, Anger Proneness), and for Improvement of Neurologic, Cognitive Function and Quality of Life Unknown status NCT01278498 Phase 4 Escitalopram;sugar pill
49 Group Mindfulness-Based Cognitive Therapy for the Treatment of Late-Life Depression and Anxiety Symptoms in Primary Care: A Randomized Controlled Trial Unknown status NCT02777905 Phase 4
50 Phase 4 Study of Vitamin D3 Supplementation for Outcomes in Patients With Unipolar Depression Unknown status NCT01390662 Phase 4

Search NIH Clinical Center for Neurotic Disorder

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Alprazolam
Amitriptyline
Amitriptyline Hydrochloride
Amoxapine
Bupropion
Bupropion hydrobromide
Bupropion Hydrochloride
Buspirone
buspirone hydrochloride
Citalopram
Citalopram hydrobromide
Clomipramine
Clomipramine Hydrochloride
Desipramine
Desipramine Hydrochloride
Doxepin
Doxepin Hydrochloride
Escitalopram
Escitalopram oxalate
Fluoxetine
Fluoxetine Hydrochloride
Fluvoxamine
Fluvoxamine Maleate
HYPERICUM PERFORATUM (ST. JOHN'S WORT)
Imipramine
Imipramine Hydrochloride
Imipramine pamoate
Isocarboxazid
Isoflurane
Kava preparation
Lithium
Lithium Aspartate
Lithium Carbonate
lithium citrate
Lorazepam
Maprotiline
Maprotiline Hydrochloride
Methylphenidate
Methylphenidate Hydrochloride
Mirtazapine
nefazodone
Nortriptyline
Nortriptyline Hydrochloride
Paroxetine
Paroxetine Hydrochloride
Phenelzine
Phenelzine Sulfate
Pramipexole
Pramipexole dihydrochloride
Protriptyline
Protriptyline Hydrochloride
Selegiline
selegiline hydrochloride
Sertraline
Sertraline Hydrochloride
Temazepam
Tranylcypromine
Tranylcypromine sulfate
Trazodone
Trazodone Hydrochloride
Tricyclic Antidepressant [EPC]
Trimipramine
Trimipramine Maleate
venlafaxine
Venlafaxine hydrochloride

Cochrane evidence based reviews: adjustment disorders

Genetic Tests for Neurotic Disorder

Anatomical Context for Neurotic Disorder

MalaCards organs/tissues related to Neurotic Disorder:

40
Brain, Testes, Heart, Cortex, Breast, Prefrontal Cortex, Eye

Publications for Neurotic Disorder

Articles related to Neurotic Disorder:

(show top 50) (show all 4564)
# Title Authors PMID Year
1
Detection of Malingering Using Wechsler Adult Intelligence Scale-IV for Psychiatric Patients. 61
32450624 2020
2
Pharmacological, psychological and non-invasive brain stimulation interventions for preventing depression after stroke. 61
32390167 2020
3
Anti-microbial and anti-inflammatory effects of Cheonwangbosim-dan against Helicobacter pylori-induced gastritis. 61
32476313 2020
4
[Clinical effect and safety of acupuncture in treatment of cardiac neurosis:a systematic review and meta-analysis]. 61
32447860 2020
5
Do nurses rate diseases according to prestige? A survey study. 61
32310319 2020
6
Rudolf Allers' conception of neurosis as a metaphysical conflict. 61
31544537 2020
7
Historical perspectives on evolving operational definitions of concussive brain injury: From railway spine to sport-related concussion. 61
31146639 2020
8
Pharmacological, psychological, and non-invasive brain stimulation interventions for treating depression after stroke. 61
31989584 2020
9
Prescribing Prevalence, Effectiveness, and Mental Health Safety of Smoking Cessation Medicines in Patients With Mental Disorders. 61
31289809 2020
10
Balier's French Narcissistic Theory of Ageing: Developments and Perspectives. 61
32082233 2020
11
Yokukansankachimpihange Improves the Social Isolation-Induced Sleep Disruption and Allopregnanolone Reduction in Mice. 61
32118027 2020
12
Triptolide-induced hepatotoxicity via apoptosis and autophagy in zebrafish. 61
31321794 2019
13
Can Anything Good Ever Come From Bearing Migraine Attacks? Suggestions for a Comprehensive Concept of Gain in Migraine. 61
31734850 2019
14
Differentiating Psychosomatic, Somatopsychic, Multisystem Illnesses, and Medical Uncertainty. 61
31597359 2019
15
Somatic symptoms and their association with anxiety and depression in Chinese patients with cardiac neurosis. 61
31448660 2019
16
Clinical Role of Aspirin in Mood Disorders: A Systematic Review. 61
31671812 2019
17
The Wolf Man's Glückshaube: Rereading Sergei Pankejeff's Memoir. 61
31850786 2019
18
Effectiveness of the traditional Japanese Kampo medicine Yokukansan for chronic migraine: A case report. 61
31490382 2019
19
Traumatic Hystero-Neurasthenia in Professor Charcot's Leçons du Mardi. 61
31464991 2019
20
Inventing the enemy. 61
31418830 2019
21
Insanity: A Legal and Cinematic Diagnosis. 61
31033643 2019
22
The uses of trauma in experiment: Traumatic stress and the history of experimental neurosis, c. 1925-1975. 61
31829295 2019
23
[The energy metaphor for the human body and its effect on the rise of neurasthenia, neurosis and depression]. 61
31531581 2019
24
Premature mortality of people with personality disorder in the Nottingham Study of Neurotic Disorder. 61
31414571 2019
25
Construction of Disease Similarity Networks Using Concept Embedding and Ontology. 61
31437962 2019
26
Between Shell Shock and PTSD? 'Accident Neurosis' and Its Sequelae in Post-War Britain. 61
31384101 2019
27
Sex dimorphism in the distribution of adipose tissue and its influence on proinflammatory adipokines and cardiometabolic profiles in motor complete spinal cord injury. 61
29465306 2019
28
[Rat man. A review]. 61
32119725 2019
29
Factors associated with long-term prescription of benzodiazepine: a retrospective cohort study using a health insurance database in Japan. 61
31350250 2019
30
A Psychoanalytical Approach to Diogenes Syndrome. 61
31090506 2019
31
Neuro-Cognition in Adolescents with Dissociative Disorder: A Study from a Tertiary Care Center of North India. 61
31142926 2019
32
Increased cerebrospinal fluid neurofilament light chain in central nervous system inflammatory demyelinating disease. 61
30771578 2019
33
Ménière's disease with unremitting floating sensation is associated with canal paresis, gravity-sensitive dysfunction, mental illness, and bilaterality. 61
30072163 2019
34
Suicide attempts by drug overdose at Jichi Medical University Hospital emergency centre: A study of patient characteristics and quantity of drug overdose. 61
30318306 2019
35
The impact of inhaled bronchodilators on bronchopulmonary dysplasia: a nonrandomized comparison from the NEuroSIS trial. 61
30922128 2019
36
Neurosis and true dermatosis: a case of ossified pilomatricoma developing within a self-inflicted ulcer. 61
30865412 2019
37
A descriptive epidemiological study of disability prevalence attributed to neurotic disorders in China. 61
30611025 2019
38
Effect of Yokukansan and Yokukansankachimpihange on Aggressive Behavior, 5-HT Receptors and Arginine Vasopressin Expression in Social Isolation-Reared Mice. 61
31787717 2019
39
A Systematic Review of the Effect of Probiotic Supplementation on Schizophrenia Symptoms. 61
30947230 2019
40
The mysterious "mental illness" of a philosopher: the case of Blaise Pascal. 61
32239123 2019
41
Polydatin Attenuates Neuronal Loss via Reducing Neuroinflammation and Oxidative Stress in Rat MCAO Models. 61
31293416 2019
42
Ganoderma sinense polysaccharide: An adjunctive drug used for cancer treatment. 61
31030747 2019
43
Ganoderma lucidum polysaccharide used for treating physical frailty in China. 61
31030748 2019
44
Gender differences in mental health and substance use disorders and related healthcare services utilization. 61
30536669 2019
45
Correlation Analysis Between Attentional Bias and Somatic Symptoms in Depressive Disorders. 61
31920752 2019
46
Prevalence and Screening of Mental Illness among Remand Prisoners in Hong Kong. 61
30563950 2018
47
Hallucination in Adolescence-Or, Nora in Nowhereland Between Neurosis and Psychosis. 61
30300083 2018
48
Severe hair loss associated with psychotropic drugs in psychiatric inpatients-Data from an observational pharmacovigilance program in German-speaking countries. 61
30193142 2018
49
Effects of Antiparkinson Medication on Cognition in Parkinson's Disease: A Systematic Review. 61
29747716 2018
50
Simultaneous Determination of the Traditional Herbal Formula Ukgansan and the In Vitro Antioxidant Activity of Ferulic Acid as an Active Compound. 61
29986512 2018

Variations for Neurotic Disorder

Expression for Neurotic Disorder

Search GEO for disease gene expression data for Neurotic Disorder.

Pathways for Neurotic Disorder

Pathways related to Neurotic Disorder according to KEGG:

36
# Name Kegg Source Accession
1 Neuroactive ligand-receptor interaction hsa04080
2 Dopaminergic synapse hsa04728

Pathways related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.68 SLC6A4 MAOA HTR2A HTR1A
2
Show member pathways
11.65 TH MAOA BDNF
3 11.38 TNF TH SLC6A4 MAOA HTR2A HTR1A
4
Show member pathways
11.19 TNF TH SLC6A4 MAOA
5 10.9 SLC6A4 MAOA HTR2A HTR1A
6
Show member pathways
10.62 TH SLC6A4 MAOA HTR1A
7 10.51 TH MAOA

GO Terms for Neurotic Disorder

Biological processes related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.76 TH SLC6A4 HTR2A BDNF
2 response to estradiol GO:0032355 9.65 TH SLC6A4 GPX4
3 vasoconstriction GO:0042310 9.43 SLC6A4 HTR1A
4 behavior GO:0007610 9.4 HTR2A HTR1A
5 neurotransmitter biosynthetic process GO:0042136 9.37 TH SLC6A4
6 response to salt stress GO:0009651 9.32 TNF TH
7 cellular response to nicotine GO:0071316 9.26 TNF TH
8 positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 9.16 LY96 LY86
9 serotonin receptor signaling pathway GO:0007210 8.96 HTR2A HTR1A
10 memory GO:0007613 8.92 TH SLC6A4 HTR2A BDNF

Molecular functions related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 8.8 SLC6A4 HTR2A HTR1A

Sources for Neurotic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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