MCID: NRT001
MIFTS: 56

Neurotic Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Neurotic Disorder

MalaCards integrated aliases for Neurotic Disorder:

Name: Neurotic Disorder 12 15 17
Neurosis 12 36 15
Adjustment Disorders 44 71
Reactive Depression 12 71
Neurotic Disorders 44 71
Neurotic Depression Reactive Type 12
Neurotic Depressive State 12
Depression, Neurotic 71
Depressive Neurosis 12
Neurotic Depression 12
Depressive Disorder 71
Psychoneurosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4964
KEGG 36 H01671
UMLS 71 C0001546 C0011579 C0011581 more

Summaries for Neurotic Disorder

KEGG : 36 Neurosis is a class of functional mental disorders involving distress but neither delusions nor hallucinations, whereby behavior is not outside socially acceptable norms. The state of research on neurosis has moved towards looking at biological and genetic substrates or mechanisms underlying neurosis. The recent literature shows acceptance of common mental disorders such as Generalized anxiety disorder (GAD), Panic disorder (PD), and Obsessive-compulsive disorder (OCD), across cultures replacing neurotic disorder. Usage of the diagnosis of neurosis has been decreased, and replaced by newer categories in the current popular classificatory systems. In the International Classification of Diseases (ICD-10), all disorders regarded as neurosis remained together but under the division of rubric 'neurotic, stress-related and somatoform disorders'. In the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), neurosis has been eliminated as a category.

MalaCards based summary : Neurotic Disorder, also known as neurosis, is related to conversion disorder and obsessive-compulsive disorder, and has symptoms including depressed reaction and depressed - symptom. An important gene associated with Neurotic Disorder is HTR1A (5-Hydroxytryptamine Receptor 1A), and among its related pathways/superpathways are Neuroactive ligand-receptor interaction and Dopaminergic synapse. The drugs Valsartan and Ropinirole have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and prefrontal cortex, and related phenotypes are behavior/neurological and cardiovascular system

Disease Ontology : 12 An anxiety disorder that involves discress but neither delusions nor hallucinations.

Wikipedia : 74 Neurosis is a class of functional mental disorders involving chronic distress, but neither delusions nor... more...

Related Diseases for Neurotic Disorder

Diseases related to Neurotic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 411)
# Related Disease Score Top Affiliating Genes
1 conversion disorder 31.9 HTR2A COMT BDNF
2 obsessive-compulsive disorder 30.3 TNF SLC6A4 POMC OXT MAOA IL6
3 duodenal ulcer 30.3 TNF INS IL6
4 arachnoiditis 30.3 TNF POMC
5 dissociative disorder 30.2 SLC6A4 OXT BDNF
6 personality disorder 30.1 SLC6A4 MAOA HTR2A HTR1A COMT BDNF
7 obsessive-compulsive personality disorder 30.1 SLC6A4 HTR2A COMT
8 headache 30.0 SLC6A4 HTR2A COMT
9 depression 30.0 SLC6A4 MAOA HTR2A HTR1A BDNF
10 diabetes insipidus 30.0 POMC OXT INS
11 tic disorder 30.0 SLC6A4 MAOA HTR2A COMT
12 premenstrual tension 29.9 POMC LIPN
13 generalized anxiety disorder 29.9 SLC6A4 MAOA HTR2A HTR1A COMT BDNF
14 body dysmorphic disorder 29.9 SLC6A4 OXT MAOA HTR2A
15 cyclothymic disorder 29.9 SLC6A4 HTR2A COMT
16 alcohol use disorder 29.9 SLC6A4 HTR2A HTR1A COMT BDNF
17 cellulitis 29.8 TNF INS IL6
18 gout 29.8 TNF INS IL6
19 brain injury 29.8 IL6 COMT BDNF
20 eating disorder 29.8 SLC6A4 POMC COMT BDNF
21 hyperprolactinemia 29.8 POMC INS HTR2A
22 panic disorder 29.8 SLC6A4 POMC MAOA HTR2A HTR1A COMT
23 thyroid gland disease 29.7 POMC INS IL6
24 hyperthyroidism 29.6 POMC INS IL6
25 opiate dependence 29.6 SLC6A4 POMC NGF
26 adrenal gland pheochromocytoma 29.6 NGF BDNF
27 sexual sadism 29.6 OXT MAOA COMT BDNF
28 conduct disorder 29.6 SLC6A4 POMC MAOA COMT
29 agoraphobia 29.6 SLC6A4 MAOA HTR2A HTR1A COMT BDNF
30 borderline personality disorder 29.6 SLC6A4 MAOA HTR2A HTR1A COMT BDNF
31 atypical depressive disorder 29.4 SLC6A4 POMC MAOA IL6 HTR2A HTR1A
32 post-traumatic stress disorder 29.4 SLC6A4 POMC MAOA HTR2A COMT BDNF
33 diarrhea 29.4 TNF SLC6A4 POMC IL6 ACHE
34 adjustment disorder 29.3 SLC6A4 POMC OXT HTR2A HTR1A BDNF
35 dysthymic disorder 29.3 SLC6A4 POMC MAOA INS IL6 HTR2A
36 paranoid schizophrenia 29.3 SLC6A4 MAOA IL6 HTR2A HTR1A COMT
37 dermatitis, atopic 29.3 TNF NGF IL6 BDNF
38 schizoaffective disorder 29.3 SLC6A4 INS HTR2A HTR1A COMT BDNF
39 hypochondriasis 29.3 SLC6A4 POMC OXT HTR2A HTR1A BDNF
40 antisocial personality disorder 29.2 SLC6A4 OXT MAOA HTR2A COMT
41 acute stress disorder 29.2 SLC6A4 POMC OXT IL6 HTR1A BDNF
42 somatoform disorder 29.2 SLC6A4 NGF IL6 COMT BDNF
43 melancholia 29.1 TNF SLC6A4 POMC MAOA IL6 HTR2A
44 mood disorder 29.1 SLC6A4 POMC MAOA IL6 HTR2A HTR1A
45 social phobia 29.1 SLC6A4 OXT MAOA HTR2A HTR1A COMT
46 narcolepsy 29.0 TNF SLC6A4 MAOA IL6 HTR2A COMT
47 somatization disorder 29.0 SLC6A4 POMC PCSK5 OXT IL6 HTR1A
48 vascular dementia 28.8 TNF NGF IL6 HTR1A CHAT ACHE
49 substance abuse 28.7 SLC6A4 POMC MAOA INS IL6 HTR2A
50 paine syndrome 28.7 TNF SLC6A4 NGF IL6 COMT BDNF

Graphical network of the top 20 diseases related to Neurotic Disorder:



Diseases related to Neurotic Disorder

Symptoms & Phenotypes for Neurotic Disorder

UMLS symptoms related to Neurotic Disorder:


depressed reaction, depressed - symptom

MGI Mouse Phenotypes related to Neurotic Disorder:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.32 ACHE BDNF CHAT COMT HTR1A HTR2A
2 cardiovascular system MP:0005385 10.27 ACHE CHAT COMT HTR1A IL6 INS
3 homeostasis/metabolism MP:0005376 10.24 ACHE BDNF CHAT COMT HTR1A IL6
4 endocrine/exocrine gland MP:0005379 10.1 BDNF COMT HTR2A IL6 INS OXT
5 mortality/aging MP:0010768 10.1 ACHE BDNF CHAT HTR1A IL6 INS
6 digestive/alimentary MP:0005381 10.09 BDNF CHAT HTR2A IL6 INS OXT
7 adipose tissue MP:0005375 10.04 ACHE HTR1A IL6 INS OXT POMC
8 nervous system MP:0003631 10 ACHE BDNF CHAT COMT HTR1A IL6
9 muscle MP:0005369 9.86 ACHE CHAT HTR2A IL6 INS NGF
10 no phenotypic analysis MP:0003012 9.56 ACHE BDNF HTR1A INS NGF PCSK5
11 respiratory system MP:0005388 9.17 ACHE BDNF CHAT COMT IL6 PCSK5

Drugs & Therapeutics for Neurotic Disorder

Drugs for Neurotic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 581)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
2
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 5095 497540
3
Suvorexant Approved, Investigational Phase 4 1030377-33-3
4
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
5
Oxcarbazepine Approved Phase 4 28721-07-5 34312
6
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
7
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
8
Doxepin Approved, Investigational Phase 4 1668-19-5 667477 667468
9
Trimipramine Approved Phase 4 739-71-9 5584 4055
10
Clozapine Approved Phase 4 5786-21-0 2818
11
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
12
Topiramate Approved Phase 4 97240-79-4 5284627
13
Maprotiline Approved, Investigational Phase 4 10262-69-8 4011
14
Protriptyline Approved Phase 4 438-60-8 4976
15
Isocarboxazid Approved Phase 4 59-63-2 3759
16
Desipramine Approved, Investigational Phase 4 50-47-5 2995
17
Moclobemide Approved, Investigational Phase 4 71320-77-9 4235
18
Ziprasidone Approved Phase 4 146939-27-7 60854
19
Methadone Approved Phase 4 76-99-3 4095
20
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
21
Brexpiprazole Approved, Investigational Phase 4 913611-97-9 11978813
22
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
23
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
24
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
25
Memantine Approved, Investigational Phase 4 19982-08-2 4054
26
Methohexital Approved Phase 4 151-83-7 9034
27
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
28
Testosterone enanthate Approved Phase 4 315-37-7 9416
29
Methyltestosterone Approved Phase 4 58-18-4 6010
30
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
31
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
32
Promethazine Approved, Investigational Phase 4 60-87-7 4927
33
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
34
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
35
Ribavirin Approved Phase 4 36791-04-5 37542
36
Curcumin Approved, Experimental, Investigational Phase 4 458-37-7 969516
37
Iloperidone Approved Phase 4 133454-47-4 71360
38
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
39
Calcium carbonate Approved, Investigational Phase 4 471-34-1
40
Zolpidem Approved Phase 4 82626-48-0 5732
41
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
42
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
43
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
44
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
45
Donepezil Approved Phase 4 120014-06-4 3152
46
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
47
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
48
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
49
Remifentanil Approved Phase 4 132875-61-7 60815
50
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833

Interventional clinical trials:

(show top 50) (show all 4156)
# Name Status NCT ID Phase Drugs
1 Multi-dimensional Diagnosis,Individualized Therapy,and Management Technique for Major Depressive Disorder:Based on Clinical and Pathological Characteristics Unknown status NCT03219008 Phase 4 Fluoxetine;fluoxetine + Amfebutamone;Fluvoxamine;Lithium+fluvoxamine;Mirtazapine/SNRIs;mirtazapine + SNRIs
2 Role of Inflammation Factors and Insulin Resistance in the Pathophysiology and Treatment Response of Major Depressive Disorder Unknown status NCT01699490 Phase 4 Fluoxetine + Valsartan;Fluoxetine + Placebo
3 Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder Unknown status NCT02051413 Phase 4 Venlafaxine extended release
4 Inflammatory Markers and Cognitive Function in Major Depression:a Pilot Study Unknown status NCT01391221 Phase 4 Duloxetine
5 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
6 D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression Unknown status NCT02772211 Phase 4 Ketamine;D-cycloserine;Placebo
7 Pharmacogenomics Studies of Antidepressants Unknown status NCT01204086 Phase 4 Venlafaxine;Fluoxetine
8 A Six Week, Randomized, Double-Blind Placebo-Controlled, Suvorexant Augmentation Study of Antidepressant Treatment of Major Depressive Disorder With Residual Insomnia Unknown status NCT02669030 Phase 4 suvorexant;Placebo
9 Phase 4 Study of Escitalopram Treatment and Biomarkers in Major Depressive Disorder Unknown status NCT01997580 Phase 4 escitalopram
10 Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression Unknown status NCT00291239 Phase 4
11 Effect of Escitalopram vs. Reboxetine on Somatic and Visceral Sensitivity of Patients With Major Depressive Disorder: a Randomized, Double Blind Clinical Trial Unknown status NCT00209807 Phase 4 escitalopram;Reboxetine
12 Algorithm Guided Treatment Strategies for Major Depressive Disorder Unknown status NCT01764867 Phase 4 Escitalopram;Mirtazapine;Fluoxetine;Citalopram;Escitalopram;Paroxetine;Sertraline;Fluvoxamine;Venlafaxine;Duloxetine;Mirtazapine;Bupropion;Trazodone
13 International Study to Predict Optimised Treatment - in Depression Unknown status NCT00693849 Phase 4 Escitalopram;Sertraline;Venlafaxine-XR
14 Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder Unknown status NCT00442481 Phase 4 Escitalopram
15 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar I and II Depression. Unknown status NCT00335205 Phase 4 ropinirole
16 Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder Unknown status NCT01460212 Phase 4 SSRI antidepressants
17 Clinical Trial of the Use of Ketamine in Treatment Resistant Depression Unknown status NCT02610712 Phase 4 Ketamine
18 Escitalopram Treatment of Major Depression in Diabetes Mellitus: An Open Label Unknown status NCT00650897 Phase 4 Escitalopram
19 Brain Mechanisms and Targeting Insomnia in Major Depression Unknown status NCT00628914 Phase 4 escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
20 A Randomised Trial Investigating the Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder. Unknown status NCT01483053 Phase 4 Agomelatine;Escitalopram
21 White Matter Structure and Response to Treatment With Antidepressants: a Study of Desvenlafaxine in Major Depression. A Pilot Study Unknown status NCT01492621 Phase 4 Desvenlafaxine
22 Prediction of Individual Treatment Response Based on Brain Changes at the Early Phase of Antidepressant Treatment in Major Depressive Disorder Using Machine Learning Classification Analysis Unknown status NCT02330679 Phase 4 Desvenlafaxine;Placebo
23 Randomized,Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder Unknown status NCT02273154 Phase 4 Buspirone;Paroxetine
24 Assessing Tolerability and Efficacy of Vortioxetine Versus SSRIs in Elderly Patients With Depression: a Pragmatic, Multicenter, Open-label, Parallel-group, Superiority, Randomized Trial Unknown status NCT03779789 Phase 4 Vortioxetine;Sertraline;citalopram;Escitalopram;Paroxetine;Fluoxetine;Fluvoxamine
25 Duloxetine for the Treatment of Major Depression in Midlife Women: Effects on Brain Structure and Functioning, Mood, and Quality of Life Unknown status NCT00889369 Phase 4 Duloxetine
26 A Randomised Pragmatic Trial Comparing the Clinical and Cost Effectiveness of Lithium and Quetiapine Augmentation in Treatment Resistant Depression Unknown status NCT03004521 Phase 4 Quetiapine;Lithium
27 Cognitive Dysfunction in Patients With Major Depressive Disorder, Clinical Peculiarities, Biological Markers, and Treatment Efficacy Unknown status NCT03187093 Phase 4 Vortioxetine;Escitalopram
28 Neurochemical,Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder Unknown status NCT02346682 Phase 4 venlafaxine
29 The Effect and Reliability of Escitalopram in the Treatment of Adolescents With Major Depressive Disorder or Anxiety Disorders Unknown status NCT03122158 Phase 4 Escitalopram
30 Ketamine Co-induction for Patients With Major Depressive Disorder; a Randomized Clinical Trial Unknown status NCT03666494 Phase 4 Ketamine Hydrochloride;Propofol;Fentanyl
31 Interactions Between The Serotonin Transporter And Sympathetic Nervous System Activation In Patients With Major Depressive Disorder - Understanding The Link Between The Brain And The Heart Unknown status NCT01568307 Phase 4 Participants will be prescribed an approved selective serotonin re-uptake inhibitor (SSRI) antidepressant.
32 Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disorder Unknown status NCT02294305 Phase 4 Vortioxetine;Placebo
33 THE AIUNI - Integral Assessment in Unipolar Depression Unknown status NCT02268487 Phase 4 Sertraline
34 A Randomized Controlled Study Comparing Fluoxetine With Bupropion for Impulsivity and Suicidality in Patients With Major Depressive Disorder and Comorbid Alcoholism (Abuse or Dependence) Unknown status NCT00449007 Phase 4 fluoxetine;bupropion
35 A Controlled Study of the Efficacy of Botulinum Toxin A (Botox) for the Treatment of Major Depressive Disorder (MDD) Unknown status NCT01556971 Phase 4 Botox;Saline Solution
36 Hyperventilation and ECT Seizure Duration: Effects on Cerebral Oxygen Saturation, and Therapeutic Outcome With Comparisons Between Etomidate and Ketamine in Patients With Major Depressive Disorder Unknown status NCT02924090 Phase 4 Etomidate;Ketamine
37 Prospective 24-week Study, Comparing Clinical Outcomes Between Switching Antidepressants and Maintaining the Same Antidepressant in Patients With Major Depressive Disorder Who do Not Show a 20% Reduction in Symptoms at Week 2 Unknown status NCT00519012 Phase 4 Sertraline to Paroxetine;Paroxetine to Sertraline
38 Evaluation of the Efficacy of Repetitive Transcranial Magnetic Stimulation on Cognitive, Anxiety and Depressive Symptoms in Patients Diagnosed With Major Depressive Disorder Unknown status NCT02213016 Phase 4
39 Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy Unknown status NCT02579642 Phase 4 Ketamine;Placebo
40 Antidepressant Treatments During Pregnancy and Lactation: Prediction of Drug Exposure Through Breastfeeding and Evaluation of Drug Effect on the Neonatal Adaptation and the Development of the Young Child Unknown status NCT01796132 Phase 4 SSRI/SNRI
41 Turgut Ozal Medical Center Department of Anesthesiology and Reanimation Unknown status NCT02267980 Phase 4 Sevoflurane;Ketamine;Saline
42 Behandlung Von Leichten Und Unterschwelligen Depressionen. Eine Randomisierte, Kontrollierte Studie Zum Wirksamkeitsnachweis Eines Serotonin-Wiederaufnahme-Hemmers (SSRI), Einer Kognitiven Verhaltenstherapie Und Einer Freien Therapiewahl ("Treatment of Mild and Subthreshold Depressive Disorders". A Randomized, Controlled Trial on the Efficacy of a Serotonin-Reuptake-Inhibitor (SSRI), a Cognitive-Behavioral Therapy and of Free Choice Between SSRI and CBT") Unknown status NCT00226642 Phase 4 Sertralin;Placebo
43 Phase 4 Study of Vitamin D3 Supplementation for Outcomes in Patients With Unipolar Depression Unknown status NCT01390662 Phase 4
44 A Multicenter, Double Blind Trial to Compare the Efficacy and Safety of Escitalopram With Placebo in Patients With Acute Stroke for the Prevention of Poststroke Depression and Related Symptoms (Emotional Incontinence, Anger Proneness), and for Improvement of Neurologic, Cognitive Function and Quality of Life Unknown status NCT01278498 Phase 4 Escitalopram;sugar pill
45 Exploring Alterations of Central Autonomic Modulation in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
46 A 12 Week, Open Label, Efficacy and Safety Study of Desvenlafaxine in the Treatment of Vascular Depression Unknown status NCT01974934 Phase 4 Desvenlafaxine Succinate
47 Collaborative Care for Depressed Elders in China Unknown status NCT01287494 Phase 4 Sertraline
48 a Randomized, Double Blind, Placebo-controlled, Multicenter Clinical Trial of Efficacy and Safety of Shu Gan yi Yang Capsule in the Treatment of Depression Associated With Erectile Dysfunction (Stagnation of Liver qi and Kidney Deficiency) Unknown status NCT03290313 Phase 4 shu gan yi yang capsule;shu gan yi yang capsule simulation agent
49 An Exploratory Randomized Open Comparison of Oxtellar XR® vs Oxcarbazepine IR (Trileptal®) for the Treatment of Bipolar Depression Unknown status NCT03567681 Phase 4 Extended release oxcarbazepine vs Immediate release oxcarbazepine
50 Exploratory Study to Assess the Efficacy of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer's Disease, Vascular Dementia and Mixed Vascular and Alzheimer's Dementia Unknown status NCT00229333 Phase 4 Escitalopram

Search NIH Clinical Center for Neurotic Disorder

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Alprazolam
Amitriptyline
Amitriptyline Hydrochloride
Amoxapine
Bupropion
Bupropion hydrobromide
Bupropion Hydrochloride
Buspirone
buspirone hydrochloride
Citalopram
Citalopram hydrobromide
Clomipramine
Clomipramine Hydrochloride
Desipramine
Desipramine Hydrochloride
Doxepin
Doxepin Hydrochloride
Escitalopram
Escitalopram oxalate
Fluoxetine
Fluoxetine Hydrochloride
Fluvoxamine
Fluvoxamine Maleate
HYPERICUM PERFORATUM (ST. JOHN'S WORT)
Imipramine
Imipramine Hydrochloride
Imipramine pamoate
Isocarboxazid
Isoflurane
Kava preparation
Lithium
Lithium Aspartate
Lithium Carbonate
lithium citrate
Lorazepam
Maprotiline
Maprotiline Hydrochloride
Methylphenidate
Methylphenidate Hydrochloride
Mirtazapine
nefazodone
Nortriptyline
Nortriptyline Hydrochloride
Paroxetine
Paroxetine Hydrochloride
Phenelzine
Phenelzine Sulfate
Pramipexole
Pramipexole dihydrochloride
Protriptyline
Protriptyline Hydrochloride
Selegiline
selegiline hydrochloride
Sertraline
Sertraline Hydrochloride
Temazepam
Tranylcypromine
Tranylcypromine sulfate
Trazodone
Trazodone Hydrochloride
Tricyclic Antidepressant [EPC]
Trimipramine
Trimipramine Maleate
venlafaxine
Venlafaxine hydrochloride

Cochrane evidence based reviews: adjustment disorders

Genetic Tests for Neurotic Disorder

Anatomical Context for Neurotic Disorder

MalaCards organs/tissues related to Neurotic Disorder:

40
Brain, Cortex, Prefrontal Cortex, Pituitary, Eye, Thyroid, Bone

Publications for Neurotic Disorder

Articles related to Neurotic Disorder:

(show top 50) (show all 4654)
# Title Authors PMID Year
1
A review of the effectiveness of hibiscus for treatment of metabolic syndrome. 61
33383111 2021
2
Increased Risk of Psychopathological Abnormalities in Subjects With Unilateral Hearing Loss: A Cross-Sectional Study. 61
32734740 2021
3
[Concepts of nymphomania in the German academic psychiatry: Changes over the last two centuries]. 61
33592669 2021
4
Efficacy of Yokukansan, a traditional Japanese herbal medicine, in patients with dizziness and irritability. 61
33526322 2021
5
Gender differences in plasma pharmacokinetics and hepatic metabolism of geissoschizine methyl ether from Uncaria hook in rats. 61
32898626 2021
6
Menopause distress: A person centered definition. 61
33475570 2020
7
Clinical Scenario of Venerophobia in Patients Presenting in Outpatient Department. 61
33210645 2020
8
Abnormal cortisol awakening responses in patients with neurotic and personality disorders admitted for psychotherapy in day hospital. 61
32836009 2020
9
Unique pathological changes in the pancreas of fulminant type 1 diabetes. 61
33088638 2020
10
Short-term Changes in Self-rating Depression Scale Scores after Smoking Cessation in Neurotic Patients. 61
33055476 2020
11
Delineating the electrophysiological signature of dystonia. 61
32712678 2020
12
Postoperative Outcomes After Transsacral Epiduroscopic Laser Decompression in Japanese Patients: Denervation Therapy for Discogenic Low-Back Pain. 61
32780687 2020
13
Association of low-dosage systemic corticosteroid use with disease burden in asthma. 61
32753647 2020
14
[Acting out in the four psychic structures]. 61
33129405 2020
15
Do nurses rate diseases according to prestige? A survey study. 61
32310319 2020
16
Detection of Malingering Using Wechsler Adult Intelligence Scale-IV for Psychiatric Patients. 61
32450624 2020
17
Analysis of Consistency between Forensic Psychiatry Identification Diagnosis and Clinical Diagnosis of 1 369 Cases. 61
32705845 2020
18
[Clinical effect and safety of acupuncture in treatment of cardiac neurosis:a systematic review and meta-analysis]. 61
32447860 2020
19
Pharmacological, psychological and non-invasive brain stimulation interventions for preventing depression after stroke. 61
32390167 2020
20
Anti-microbial and anti-inflammatory effects of Cheonwangbosim-dan against Helicobacter pylori-induced gastritis. 61
32476313 2020
21
Rudolf Allers' conception of neurosis as a metaphysical conflict. 61
31544537 2020
22
Historical perspectives on evolving operational definitions of concussive brain injury: From railway spine to sport-related concussion. 61
31146639 2020
23
[Hysteria laryngea; First thesis in the Netherlands on hysteria (1849)]. 61
32700300 2020
24
Balier's French Narcissistic Theory of Ageing: Developments and Perspectives. 61
32082233 2020
25
[Evolution of the concept of psychopathy in Russian psychiatry from V.H. Kandinskiy to S.A. Sukhanov]. 61
32678551 2020
26
Yokukansankachimpihange Improves the Social Isolation-Induced Sleep Disruption and Allopregnanolone Reduction in Mice. 61
32118027 2020
27
[Doctrine of psychopathies: the concept of M.O. Gurevich and M.Ja. Serejskij]. 61
33244962 2020
28
Pharmacological, psychological, and non-invasive brain stimulation interventions for treating depression after stroke. 61
31989584 2020
29
Prescribing Prevalence, Effectiveness, and Mental Health Safety of Smoking Cessation Medicines in Patients With Mental Disorders. 61
31289809 2020
30
[The severity of neurotic disorders and social masochism in chemical addicts]. 61
33081442 2020
31
Triptolide-induced hepatotoxicity via apoptosis and autophagy in zebrafish. 61
31321794 2019
32
Can Anything Good Ever Come From Bearing Migraine Attacks? Suggestions for a Comprehensive Concept of Gain in Migraine. 61
31734850 2019
33
The Wolf Man's Glückshaube: Rereading Sergei Pankejeff's Memoir. 61
31850786 2019
34
Clinical Role of Aspirin in Mood Disorders: A Systematic Review. 61
31671812 2019
35
Somatic symptoms and their association with anxiety and depression in Chinese patients with cardiac neurosis. 61
31448660 2019
36
Differentiating Psychosomatic, Somatopsychic, Multisystem Illnesses, and Medical Uncertainty. 61
31597359 2019
37
Inventing the enemy. 61
31418830 2019
38
Insanity: A Legal and Cinematic Diagnosis. 61
31033643 2019
39
[The energy metaphor for the human body and its effect on the rise of neurasthenia, neurosis and depression]. 61
31531581 2019
40
The uses of trauma in experiment: Traumatic stress and the history of experimental neurosis, c. 1925-1975. 61
31829295 2019
41
Traumatic Hystero-Neurasthenia in Professor Charcot's Leçons du Mardi. 61
31464991 2019
42
Iatrogenic aggravation of anxiety and neurosis. 61
32985453 2019
43
Effectiveness of the traditional Japanese Kampo medicine Yokukansan for chronic migraine: A case report. 61
31490382 2019
44
Between Shell Shock and PTSD? 'Accident Neurosis' and Its Sequelae in Post-War Britain. 61
31384101 2019
45
Construction of Disease Similarity Networks Using Concept Embedding and Ontology. 61
31437962 2019
46
Premature mortality of people with personality disorder in the Nottingham Study of Neurotic Disorder. 61
31414571 2019
47
Sex dimorphism in the distribution of adipose tissue and its influence on proinflammatory adipokines and cardiometabolic profiles in motor complete spinal cord injury. 61
29465306 2019
48
Factors associated with long-term prescription of benzodiazepine: a retrospective cohort study using a health insurance database in Japan. 61
31350250 2019
49
[Rat man. A review]. 61
32119725 2019
50
A Psychoanalytical Approach to Diogenes Syndrome. 61
31090506 2019

Variations for Neurotic Disorder

Expression for Neurotic Disorder

Search GEO for disease gene expression data for Neurotic Disorder.

Pathways for Neurotic Disorder

Pathways related to Neurotic Disorder according to KEGG:

36
# Name Kegg Source Accession
1 Neuroactive ligand-receptor interaction hsa04080
2 Dopaminergic synapse hsa04728

Pathways related to Neurotic Disorder according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1 12.15 POMC OXT HTR1A BDNF
2 11.79 SLC6A4 MAOA HTR2A HTR1A
3 11.76 TNF POMC MAOA IL6
4
Show member pathways
11.63 TNF NGF BDNF
5 11.6 NGF CHAT BDNF
6 11.49 TNF SLC6A4 NGF MAOA IL6 HTR2A
7 11.39 INS IL6 ACHE
8
Show member pathways
11.3 TNF SLC6A4 MAOA ACHE
9 11.07 SLC6A4 MAOA HTR2A HTR1A
10
Show member pathways
10.96 SLC6A4 MAOA COMT ACHE
11
Show member pathways
10.82 SLC6A4 MAOA HTR1A COMT
12 10.7 MAOA COMT
13 10.63 CHAT ACHE
14
Show member pathways
10.6 MAOA COMT CHAT ACHE
15 10.34 CHAT ACHE
16
Show member pathways
10.16 PCSK5 NGF

GO Terms for Neurotic Disorder

Cellular components related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.65 NGF HTR2A HTR1A COMT BDNF
2 synapse GO:0045202 9.63 SLC6A4 PCDHB14 HTR2A HTR1A CHAT ACHE
3 extracellular space GO:0005615 9.61 TNF POMC PCSK5 OXT NGF INS
4 secretory granule GO:0030141 9.54 POMC PCSK5 OXT
5 Golgi lumen GO:0005796 9.5 PCSK5 NGF INS
6 extracellular region GO:0005576 9.32 TNF POMC PCSK5 OXT NGF LIPN

Biological processes related to Neurotic Disorder according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.91 TNF SLC6A4 NGF INS IL6
2 cytokine-mediated signaling pathway GO:0019221 9.88 TNF POMC MAOA IL6
3 female pregnancy GO:0007565 9.75 PCSK5 OXT COMT
4 response to glucocorticoid GO:0051384 9.65 TNF OXT IL6
5 catecholamine metabolic process GO:0006584 9.59 MAOA COMT
6 synapse assembly GO:0007416 9.58 PCDHB14 BDNF ACHE
7 positive regulation of neuroinflammatory response GO:0150078 9.57 TNF IL6
8 nerve growth factor signaling pathway GO:0038180 9.56 NGF BDNF
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.56 TNF NGF IL6 BDNF
10 sleep GO:0030431 9.55 OXT HTR2A
11 dopamine catabolic process GO:0042420 9.54 MAOA COMT
12 negative regulation of lipid storage GO:0010888 9.52 TNF IL6
13 positive regulation of collateral sprouting GO:0048672 9.49 NGF BDNF
14 vascular endothelial growth factor production GO:0010573 9.46 TNF IL6
15 serotonin receptor signaling pathway GO:0007210 9.43 HTR2A HTR1A
16 sperm ejaculation GO:0042713 9.37 SLC6A4 OXT
17 neurotransmitter biosynthetic process GO:0042136 9.33 SLC6A4 CHAT ACHE
18 nerve growth factor processing GO:0032455 9.32 PCSK5 NGF
19 neurotransmitter catabolic process GO:0042135 9.13 MAOA COMT ACHE
20 memory GO:0007613 9.02 SLC6A4 OXT NGF HTR2A BDNF

Molecular functions related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nerve growth factor receptor binding GO:0005163 8.96 NGF BDNF
2 serotonin binding GO:0051378 8.8 SLC6A4 HTR2A HTR1A

Sources for Neurotic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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