MCID: NRT001
MIFTS: 53

Neurotic Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Neurotic Disorder

MalaCards integrated aliases for Neurotic Disorder:

Name: Neurotic Disorder 12 15 17
Adjustment Disorders 44 72 33
Neurosis 12 37 15
Reactive Depression 12 72
Neurotic Disorders 44 72
Neurotic Depression Reactive Type 12
Neurotic Depressive State 12
Depression, Neurotic 72
Depressive Neurosis 12
Neurotic Depression 12
Depressive Disorder 72
Psychoneurosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4964
KEGG 37 H01671
SNOMED-CT 68 78667006 87414006
UMLS 72 C0001546 C0011579 C0011581 more

Summaries for Neurotic Disorder

KEGG : 37
Neurosis is a class of functional mental disorders involving distress but neither delusions nor hallucinations, whereby behavior is not outside socially acceptable norms. The state of research on neurosis has moved towards looking at biological and genetic substrates or mechanisms underlying neurosis. The recent literature shows acceptance of common mental disorders such as Generalized anxiety disorder (GAD), Panic disorder (PD), and Obsessive-compulsive disorder (OCD), across cultures replacing neurotic disorder. Usage of the diagnosis of neurosis has been decreased, and replaced by newer categories in the current popular classificatory systems. In the International Classification of Diseases (ICD-10), all disorders regarded as neurosis remained together but under the division of rubric 'neurotic, stress-related and somatoform disorders'. In the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), neurosis has been eliminated as a category.

MalaCards based summary : Neurotic Disorder, also known as adjustment disorders, is related to premenstrual tension and panic disorder 1, and has symptoms including depressed reaction and depressed - symptom. An important gene associated with Neurotic Disorder is MFSD8 (Major Facilitator Superfamily Domain Containing 8), and among its related pathways/superpathways are Neuroactive ligand-receptor interaction and Dopaminergic synapse. The drugs Acetylcholine and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are behavior/neurological and nervous system

Disease Ontology : 12 An anxiety disorder that involves discress but neither delusions nor hallucinations.

Wikipedia : 75 Neurosis is a class of functional mental disorders involving chronic distress but neither delusions nor... more...

Related Diseases for Neurotic Disorder

Diseases related to Neurotic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 230)
# Related Disease Score Top Affiliating Genes
1 premenstrual tension 29.2 LRP5 LIPN
2 panic disorder 1 11.7
3 conversion disorder 11.6
4 orthostatic intolerance 11.5
5 wilson disease 11.2
6 combat disorder 11.2
7 personality disorder 10.4
8 avoidant personality disorder 10.3
9 panic disorder 10.3
10 head injury 10.3
11 dysthymic disorder 10.3
12 dissociative disorder 10.3
13 depersonalization disorder 10.3
14 alcohol dependence 10.2
15 hyperthyroidism 10.2
16 duodenal ulcer 10.2
17 epilepsy 10.2
18 obsessive-compulsive disorder 10.1
19 generalized anxiety disorder 10.1
20 depersonalization/derealization disorder 10.1
21 migraine with or without aura 1 10.1
22 heart disease 10.1
23 diabetes mellitus 10.1
24 diabetes insipidus 10.1
25 anxiety 10.1
26 spinal arachnoiditis 10.0
27 body mass index quantitative trait locus 11 10.0
28 asthma 10.0
29 body mass index quantitative trait locus 9 10.0
30 body mass index quantitative trait locus 8 10.0
31 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 10.0
32 body mass index quantitative trait locus 4 10.0
33 body mass index quantitative trait locus 10 10.0
34 body mass index quantitative trait locus 7 10.0
35 body mass index quantitative trait locus 12 10.0
36 body mass index quantitative trait locus 14 10.0
37 body mass index quantitative trait locus 18 10.0
38 body mass index quantitative trait locus 19 10.0
39 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.0
40 body mass index quantitative trait locus 20 10.0
41 angina pectoris 10.0
42 body dysmorphic disorder 10.0
43 amnestic disorder 10.0
44 arachnoiditis 10.0
45 peptic ulcer disease 10.0
46 hypoglycemia 10.0
47 47,xyy 10.0
48 raynaud disease 10.0
49 yemenite deaf-blind hypopigmentation syndrome 10.0
50 suppression amblyopia 10.0

Graphical network of the top 20 diseases related to Neurotic Disorder:



Diseases related to Neurotic Disorder

Symptoms & Phenotypes for Neurotic Disorder

UMLS symptoms related to Neurotic Disorder:


depressed reaction, depressed - symptom

MGI Mouse Phenotypes related to Neurotic Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.5 GABRA6 GABRB1 GPX4 HTR1A LRP5 MFSD8
2 nervous system MP:0003631 9.28 GABRA6 GABRB1 GPX4 HTR1A LRP5 MFSD8

Drugs & Therapeutics for Neurotic Disorder

Drugs for Neurotic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 633)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
3
Ropinirole Approved, Investigational Phase 4 91374-21-9, 91374-20-8 5095 497540
4
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
5
Cycloserine Approved Phase 4 68-41-7 6234 401
6
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
7
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
8
Brexpiprazole Approved, Investigational Phase 4 913611-97-9 11978813
9
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
10
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
11
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
12
Amitriptyline Approved Phase 4 50-48-6 2160
13
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
14
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
15
Propranolol Approved, Investigational Phase 4 525-66-6 4946
16
Mirtazapine Approved Phase 4 61337-67-5, 85650-52-8 4205
17
Testosterone Approved, Experimental, Investigational Phase 4 481-30-1, 58-22-0 6013 10204
18
Methyltestosterone Approved Phase 4 58-18-4 6010
19
Testosterone enanthate Approved Phase 4 315-37-7 9416
20
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
21
Desipramine Approved, Investigational Phase 4 50-47-5 2995
22
Memantine Approved, Investigational Phase 4 19982-08-2 4054
23
Moclobemide Approved, Investigational Phase 4 71320-77-9 4235
24
Curcumin Approved, Experimental, Investigational Phase 4 458-37-7 969516
25
Ziprasidone Approved Phase 4 146939-27-7 60854
26
Iloperidone Approved Phase 4 133454-47-4 71360
27
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
28
Terazosin Approved Phase 4 63590-64-7 5401
29
Prazosin Approved Phase 4 19216-56-9 4893
30
Zolpidem Approved Phase 4 82626-48-0 5732
31
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
32
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
33
Methohexital Approved Phase 4 151-83-7 9034
34
Ondansetron Approved Phase 4 99614-02-5 4595
35
Methadone Approved, Illicit Phase 4 76-99-3 4095
36
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
37
Ribavirin Approved Phase 4 36791-04-5 37542
38
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
39
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
40
Sodium citrate Approved, Investigational Phase 4 68-04-2
41
Trimipramine Approved Phase 4 739-71-9 5584 4055
42
Protriptyline Approved Phase 4 438-60-8 4976
43
Topiramate Approved Phase 4 97240-79-4 5284627
44
Isocarboxazid Approved Phase 4 59-63-2 3759
45
Doxepin Approved, Investigational Phase 4 1668-19-5 667477 667468
46
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
47
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
48
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
49
Calcium carbonate Approved, Investigational Phase 4 471-34-1
50
Donepezil Approved Phase 4 120014-06-4 3152

Interventional clinical trials:

(show top 50) (show all 4029)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study of Escitalopram Treatment and Biomarkers in Major Depressive Disorder Unknown status NCT01997580 Phase 4 escitalopram
2 The Effect and Reliability of Escitalopram in the Treatment of Adolescents With Major Depressive Disorder or Anxiety Disorders Unknown status NCT03122158 Phase 4 Escitalopram
3 Role of Inflammation Factors and Insulin Resistance in the Pathophysiology and Treatment Response of Major Depressive Disorder Unknown status NCT01699490 Phase 4 Fluoxetine + Valsartan;Fluoxetine + Placebo
4 Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disorder Unknown status NCT02294305 Phase 4 Vortioxetine;Placebo
5 Pharmacogenomics Studies of Antidepressants Unknown status NCT01204086 Phase 4 Venlafaxine;Fluoxetine
6 Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder Unknown status NCT02051413 Phase 4 Venlafaxine extended release
7 Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder Unknown status NCT01460212 Phase 4 SSRI antidepressants
8 Randomized,Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder Unknown status NCT02273154 Phase 4 Buspirone;Paroxetine
9 Dose Response Effects of Estrogen Augmentation in Mood & Memory in Perimenopausal Depression Unknown status NCT00229450 Phase 4 estrogen
10 Clinical Trial of the Use of Ketamine in Treatment Resistant Depression Unknown status NCT02610712 Phase 4 Ketamine
11 Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression Unknown status NCT00291239 Phase 4
12 Effect of Escitalopram vs. Reboxetine on Somatic and Visceral Sensitivity of Patients With Major Depressive Disorder: a Randomized, Double Blind Clinical Trial Unknown status NCT00209807 Phase 4 escitalopram;Reboxetine
13 Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder Unknown status NCT00442481 Phase 4 Escitalopram
14 Inflammatory Markers and Cognitive Function in Major Depression:a Pilot Study Unknown status NCT01391221 Phase 4 Duloxetine
15 Exploring Alterations of Central Autonomic Modulation in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
16 Hyperventilation and ECT Seizure Duration: Effects on Cerebral Oxygen Saturation, and Therapeutic Outcome With Comparisons Between Etomidate and Ketamine in Patients With Major Depressive Disorder Unknown status NCT02924090 Phase 4 Etomidate;Ketamine
17 Turgut Ozal Medical Center Department of Anesthesiology and Reanimation Unknown status NCT02267980 Phase 4 Sevoflurane;Ketamine;Saline
18 Duloxetine for the Treatment of Major Depression in Midlife Women: Effects on Brain Structure and Functioning, Mood, and Quality of Life Unknown status NCT00889369 Phase 4 Duloxetine
19 A Randomised Trial Investigating the Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder. Unknown status NCT01483053 Phase 4 Agomelatine;Escitalopram
20 Algorithm Guided Treatment Strategies for Major Depressive Disorder Unknown status NCT01764867 Phase 4 Escitalopram;Mirtazapine;Fluoxetine;Citalopram;Escitalopram;Paroxetine;Sertraline;Fluvoxamine;Venlafaxine;Duloxetine;Mirtazapine;Bupropion;Trazodone
21 White Matter Structure and Response to Treatment With Antidepressants: a Study of Desvenlafaxine in Major Depression. A Pilot Study Unknown status NCT01492621 Phase 4 Desvenlafaxine
22 Escitalopram Treatment of Major Depression in Diabetes Mellitus: An Open Label Unknown status NCT00650897 Phase 4 Escitalopram
23 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar I and II Depression. Unknown status NCT00335205 Phase 4 ropinirole
24 A Randomized Controlled Study Comparing Fluoxetine With Bupropion for Impulsivity and Suicidality in Patients With Major Depressive Disorder and Comorbid Alcoholism (Abuse or Dependence) Unknown status NCT00449007 Phase 4 fluoxetine;bupropion
25 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
26 Evaluation of the Efficacy of Repetitive Transcranial Magnetic Stimulation on Cognitive, Anxiety and Depressive Symptoms in Patients Diagnosed With Major Depressive Disorder Unknown status NCT02213016 Phase 4
27 A Comparative Trial of TMS Approaches to Treating Depression Unknown status NCT01906905 Phase 4
28 Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene Unknown status NCT02237937 Phase 4 Paroxetine;Sertraline;Citalopram;Venlafaxine;Amitriptyline;Escitalopram;Amitriptylinoxide;Nortriptyline;Trimipramine
29 THE AIUNI - Integral Assessment in Unipolar Depression Unknown status NCT02268487 Phase 4 Sertraline
30 Exploratory Study to Assess the Efficacy of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer’s Disease, Vascular Dementia and Mixed Vascular and Alzheimer’s Dementia Unknown status NCT00229333 Phase 4 Escitalopram
31 Behandlung Von Leichten Und Unterschwelligen Depressionen. Eine Randomisierte, Kontrollierte Studie Zum Wirksamkeitsnachweis Eines Serotonin-Wiederaufnahme-Hemmers (SSRI), Einer Kognitiven Verhaltenstherapie Und Einer Freien Therapiewahl ("Treatment of Mild and Subthreshold Depressive Disorders". A Randomized, Controlled Trial on the Efficacy of a Serotonin-Reuptake-Inhibitor (SSRI), a Cognitive-Behavioral Therapy and of Free Choice Between SSRI and CBT") Unknown status NCT00226642 Phase 4 Sertralin;Placebo
32 Sequence Towards Remission in Depression Unknown status NCT01628783 Phase 4 escitalopram 10 mg;Placebo
33 Brain Mechanisms and Targeting Insomnia in Major Depression Unknown status NCT00628914 Phase 4 escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
34 Antidepressant Treatments During Pregnancy and Lactation: Prediction of Drug Exposure Through Breastfeeding and Evaluation of Drug Effect on the Neonatal Adaptation and the Development of the Young Child Unknown status NCT01796132 Phase 4 SSRI/SNRI
35 Neurochemical,Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder Unknown status NCT02346682 Phase 4 venlafaxine
36 TMSFOS: Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression Unknown status NCT02042573 Phase 4 SSRI (SEROPLEX ou ZOLOFT)
37 Treatment Prediction in Adolescent and Adult Depression Unknown status NCT00106197 Phase 4 Bupropion
38 A Double-Blind, Placebo-Controlled Study of Escitalopram in the Prevention of Depression in Patients With Acute Coronary Syndrome Unknown status NCT00140257 Phase 4 Escitalopram
39 A Double-Blind, Placebo-Controlled, Enriched Enrollment Randomized Withdrawal Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
40 A Controlled Study of the Efficacy of Botulinum Toxin A (Botox) for the Treatment of Major Depressive Disorder (MDD) Unknown status NCT01556971 Phase 4 Botox;Saline Solution
41 Prediction of Individual Treatment Response Based on Brain Changes at the Early Phase of Antidepressant Treatment in Major Depressive Disorder Using Machine Learning Classification Analysis Unknown status NCT02330679 Phase 4 Desvenlafaxine;Placebo
42 Phase 4 Study of Vitamin D3 Supplementation for Outcomes in Patients With Unipolar Depression Unknown status NCT01390662 Phase 4
43 Collaborative Care for Depressed Elders in China Unknown status NCT01287494 Phase 4 Sertraline
44 A Multicenter, Double Blind Trial to Compare the Efficacy and Safety of Escitalopram With Placebo in Patients With Acute Stroke for the Prevention of Poststroke Depression and Related Symptoms (Emotional Incontinence, Anger Proneness), and for Improvement of Neurologic, Cognitive Function and Quality of Life Unknown status NCT01278498 Phase 4 Escitalopram;sugar pill
45 A Randomized Controlled Trial of Antidepressant Maintenance for Major Depression Following Mild Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
46 Group Mindfulness-Based Cognitive Therapy for the Treatment of Late-Life Depression and Anxiety Symptoms in Primary Care: A Randomized Controlled Trial Unknown status NCT02777905 Phase 4
47 Phase 3 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4 Reboxetine
48 Prospective 24-week Study, Comparing Clinical Outcomes Between Switching Antidepressants and Maintaining the Same Antidepressant in Patients With Major Depressive Disorder Who do Not Show a 20% Reduction in Symptoms at Week 2 Unknown status NCT00519012 Phase 4 Sertraline to Paroxetine;Paroxetine to Sertraline
49 A 12 Week, Open Label, Efficacy and Safety Study of Desvenlafaxine in the Treatment of Vascular Depression Unknown status NCT01974934 Phase 4 Desvenlafaxine Succinate
50 Cymbalta for Depression as a Complication of Bereavement Unknown status NCT00658931 Phase 4 Drug treatment with Cymbalta

Search NIH Clinical Center for Neurotic Disorder

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Alprazolam
Amitriptyline
Amitriptyline Hydrochloride
Amoxapine
Amoxapine
Bupropion
Bupropion hydrobromide
Bupropion Hydrochloride
Buspirone
buspirone hydrochloride
Citalopram
Citalopram hydrobromide
Clomipramine
Clomipramine Hydrochloride
Desipramine
Desipramine Hydrochloride
Doxepin
Doxepin
Doxepin Hydrochloride
Escitalopram
Escitalopram oxalate
Fluoxetine
Fluoxetine Hydrochloride
Fluvoxamine
Fluvoxamine Maleate
HYPERICUM PERFORATUM (ST. JOHN'S WORT)
Imipramine
Imipramine Hydrochloride
Imipramine pamoate
Isocarboxazid
Isoflurane
Kava preparation
Lithium
Lithium Aspartate
Lithium Carbonate
lithium citrate
Lorazepam
Maprotiline
Maprotiline Hydrochloride
Methylphenidate
Methylphenidate Hydrochloride
Mirtazapine
nefazodone
Nortriptyline
Nortriptyline Hydrochloride
Paroxetine
Paroxetine Hydrochloride
Phenelzine
Phenelzine
Phenelzine Sulfate
Pramipexole
Pramipexole dihydrochloride
Protriptyline
Protriptyline Hydrochloride
Selegiline
selegiline hydrochloride
Sertraline
Sertraline Hydrochloride
Temazepam
Tranylcypromine
Tranylcypromine sulfate
Trazodone
Trazodone Hydrochloride
Tricyclic Antidepressant [EPC]
Trimipramine
Trimipramine Maleate
venlafaxine
Venlafaxine hydrochloride

Cochrane evidence based reviews: adjustment disorders

Genetic Tests for Neurotic Disorder

Anatomical Context for Neurotic Disorder

MalaCards organs/tissues related to Neurotic Disorder:

41
Brain, Testes, Heart, Cortex, Breast, Prefrontal Cortex, Eye

Publications for Neurotic Disorder

Articles related to Neurotic Disorder:

(show top 50) (show all 4540)
# Title Authors PMID Year
1
Inventing the enemy. 38
31418830 2019
2
Between Shell Shock and PTSD? 'Accident Neurosis' and Its Sequelae in Post-War Britain. 38
31384101 2019
3
Premature mortality of people with personality disorder in the Nottingham Study of Neurotic Disorder. 38
31414571 2019
4
Factors associated with long-term prescription of benzodiazepine: a retrospective cohort study using a health insurance database in Japan. 38
31350250 2019
5
Triptolide-induced hepatotoxicity via apoptosis and autophagy in zebrafish. 38
31321794 2019
6
Sex dimorphism in the distribution of adipose tissue and its influence on proinflammatory adipokines and cardiometabolic profiles in motor complete spinal cord injury. 38
29465306 2019
7
Prescribing Prevalence, Effectiveness, and Mental Health Safety of Smoking Cessation Medicines in Patients With Mental Disorders. 38
31289809 2019
8
A Psychoanalytical Approach to Diogenes Syndrome. 38
31090506 2019
9
Neuro-Cognition in Adolescents with Dissociative Disorder: A Study from a Tertiary Care Center of North India. 38
31142926 2019
10
Historical perspectives on evolving operational definitions of concussive brain injury: From railway spine to sport-related concussion. 38
31146639 2019
11
Increased cerebrospinal fluid neurofilament light chain in central nervous system inflammatory demyelinating disease. 38
30771578 2019
12
Insanity: A Legal and Cinematic Diagnosis. 38
31033643 2019
13
Ménière's disease with unremitting floating sensation is associated with canal paresis, gravity-sensitive dysfunction, mental illness, and bilaterality. 38
30072163 2019
14
The impact of inhaled bronchodilators on bronchopulmonary dysplasia: a nonrandomized comparison from the NEuroSIS trial. 38
30922128 2019
15
Suicide attempts by drug overdose at Jichi Medical University Hospital emergency centre: A study of patient characteristics and quantity of drug overdose. 38
30318306 2019
16
A descriptive epidemiological study of disability prevalence attributed to neurotic disorders in China. 38
30611025 2019
17
Neurosis and true dermatosis: a case of ossified pilomatricoma developing within a self-inflicted ulcer. 38
30865412 2019
18
A Systematic Review of the Effect of Probiotic Supplementation on Schizophrenia Symptoms. 38
30947230 2019
19
Ganoderma sinense polysaccharide: An adjunctive drug used for cancer treatment. 38
31030747 2019
20
Ganoderma lucidum polysaccharide used for treating physical frailty in China. 38
31030748 2019
21
Polydatin Attenuates Neuronal Loss via Reducing Neuroinflammation and Oxidative Stress in Rat MCAO Models. 38
31293416 2019
22
Gender differences in mental health and substance use disorders and related healthcare services utilization. 38
30536669 2019
23
Prevalence and Screening of Mental Illness among Remand Prisoners in Hong Kong. 38
30563950 2018
24
Hallucination in Adolescence-Or, Nora in Nowhereland Between Neurosis and Psychosis. 38
30300083 2018
25
Severe hair loss associated with psychotropic drugs in psychiatric inpatients-Data from an observational pharmacovigilance program in German-speaking countries. 38
30193142 2018
26
"The Neurosis That Has Possessed Us": Political Repression in the Cold War Medical Profession. 38
29718289 2018
27
Simultaneous Determination of the Traditional Herbal Formula Ukgansan and the In Vitro Antioxidant Activity of Ferulic Acid as an Active Compound. 38
29986512 2018
28
Effects of Antiparkinson Medication on Cognition in Parkinson's Disease: A Systematic Review. 38
29747716 2018
29
The influence of level of spinal cord injury on adipose tissue and its relationship to inflammatory adipokines and cardiometabolic profiles. 38
28758566 2018
30
Psychogenic voice disorders. 38
30190444 2018
31
Antipsychotic Prescribing and Safety Monitoring Practices in Children and Youth: A Population-Based Study in Alberta, Canada. 38
29453686 2018
32
The ethical dimension of analytical psychology. 38
29504686 2018
33
Massive GGAAs in genomic repetitive sequences serve as a nuclear reservoir of NF-κB. 38
29748061 2018
34
Social involvement issues in patients with Becker muscular dystrophy: A questionnaire survey of subjects from a patient registry. 38
29196072 2018
35
Specific agreement on ordinal and multiple nominal outcomes can be calculated for more than two raters. 38
29217452 2018
36
Yokukansan, a traditional Japanese herbal medicine, enhances the anxiolytic effect of fluvoxamine and reduces cortical 5-HT2A receptor expression in mice. 38
29382554 2018
37
A meta-analysis of the use of probiotics to alleviate depressive symptoms. 38
29197739 2018
38
[Lupus-like syndrome in patients treated with anti-TNF-α factors]. 38
30020046 2018
39
Working across species down on the farm: Howard S. Liddell and the development of comparative psychopathology, c. 1923-1962. 38
29417236 2018
40
[Gelototherapy in the practice of the psychotherapist]. 38
30698563 2018
41
[Psychopathological features of affective disorders in schizotypal disorder]. 38
30040794 2018
42
[To the origins of the 'unitary psychosis' doctrine: from Aretaeus to V. Chiarugi]. 38
29927415 2018
43
Factors that influence delaying initial psychiatric treatment in rural Cambodia: A pilot study. 38
30383851 2018
44
Prevalence of mental illness and their association with sociodemographic factors in the rural geriatric population in Chittoor, Andhra Pradesh, India: A community-based study. 38
30788375 2018
45
Potential Application of Yokukansan as a Remedy for Parkinson's Disease. 38
30671124 2018
46
Creative Minds in the Aftermath of the Great War: Four Neurologically Wounded Artists. 38
30336468 2018
47
[Mental impairment in children with cerebral palsy: diagnosis and treatment]. 38
29560951 2018
48
Predictors of substance abuse among risky drivers: The role of personality characteristics and mental health. 38
30693300 2018
49
The effects of Mucuna pruriens extract on histopathological and biochemical features in the rat model of ischemia. 38
28953092 2017
50
Organization and Scope of the Neuro-Psychiatric Unit. 38
29076856 2017

Variations for Neurotic Disorder

Expression for Neurotic Disorder

Search GEO for disease gene expression data for Neurotic Disorder.

Pathways for Neurotic Disorder

Pathways related to Neurotic Disorder according to KEGG:

37
# Name Kegg Source Accession
1 Neuroactive ligand-receptor interaction hsa04080
2 Dopaminergic synapse hsa04728

Pathways related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.78 GABRB1 GABRA6
2 10.56 GABRB1 GABRA6
3 9.85 GABRB1 GABRA6

GO Terms for Neurotic Disorder

Cellular components related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chloride channel complex GO:0034707 8.96 GABRB1 GABRA6
2 GABA-A receptor complex GO:1902711 8.62 GABRB1 GABRA6

Biological processes related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system process GO:0050877 9.26 GABRB1 GABRA6
2 regulation of postsynaptic membrane potential GO:0060078 9.16 GABRB1 GABRA6
3 chemical synaptic transmission GO:0007268 9.13 HTR1A GABRB1 GABRA6
4 gamma-aminobutyric acid signaling pathway GO:0007214 8.62 GABRB1 GABRA6

Molecular functions related to Neurotic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chloride channel activity GO:0005254 9.32 GABRB1 GABRA6
2 extracellular ligand-gated ion channel activity GO:0005230 9.26 GABRB1 GABRA6
3 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 9.16 GABRB1 GABRA6
4 GABA-A receptor activity GO:0004890 8.96 GABRB1 GABRA6
5 GABA-gated chloride ion channel activity GO:0022851 8.62 GABRB1 GABRA6

Sources for Neurotic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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