MCID: NRT002
MIFTS: 31

Neurotic Excoriation

Categories: Neuronal diseases, Skin diseases

Aliases & Classifications for Neurotic Excoriation

MalaCards integrated aliases for Neurotic Excoriation:

Name: Neurotic Excoriation 12 15 17
Factitious Skin Disease 12 71
Dermatitis Artefacta 12
Dermatitis Factitia 12
Dermatitis Ficta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9165
ICD9CM 34 698.4
SNOMED-CT 67 402736003
ICD10 32 L98.1
UMLS 71 C1274184

Summaries for Neurotic Excoriation

MalaCards based summary : Neurotic Excoriation, also known as factitious skin disease, is related to cellulitis and skin disease, and has symptoms including pruritus, pruritus ani and pruritus and related conditions. An important gene associated with Neurotic Excoriation is SLITRK1 (SLIT And NTRK Like Family Member 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Cell junction organization. The drugs Lamotrigine and Sodium Channel Blockers have been mentioned in the context of this disorder. Affiliated tissues include skin.

Related Diseases for Neurotic Excoriation

Diseases related to Neurotic Excoriation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 cellulitis 29.7 DST COL17A1
2 skin disease 29.5 DST COL7A1 COL17A1
3 epidermolysis bullosa 29.4 DST COL7A1 COL17A1
4 epidermolysis bullosa dystrophica 29.4 DST COL7A1 COL17A1
5 bullous pemphigoid 29.2 DST COL17A1
6 personality disorder 10.7
7 avoidant personality disorder 10.5
8 dermatitis 10.5
9 borderline personality disorder 10.4
10 factitious disorder 10.4
11 pyoderma 10.4
12 pyoderma gangrenosum 10.4
13 vasculitis 10.3
14 neurofibromatosis, type ii 10.3
15 dowling-degos disease 1 10.2
16 exanthem 10.2
17 multiple personality disorder 10.2
18 panniculitis 10.2
19 basal cell carcinoma 10.2
20 contact dermatitis 10.2
21 headache 10.2
22 obsessive-compulsive disorder 10.2
23 porphyria cutanea tarda 10.2
24 raynaud disease 10.2
25 anxiety 10.2
26 trichotillomania 10.2
27 sexual disorder 10.2
28 porphyria 10.2
29 plague 10.2
30 keloid disorder 10.2
31 raynaud phenomenon 10.2
32 osteomyelitis 10.1
33 somatoform disorder 10.1
34 mite infestation 10.1 FLNA COL17A1
35 ainhum 10.1
36 alcohol dependence 10.1
37 attention deficit-hyperactivity disorder 10.1
38 schizophrenia 10.1
39 dermatitis, atopic 10.1
40 chromosome 1p36 deletion syndrome 10.1
41 hepatitis c virus 10.1
42 t-cell lymphoma, subcutaneous panniculitis-like 10.1
43 cutaneous t cell lymphoma 10.1
44 physical disorder 10.1
45 igg4-related disease 10.1
46 dissociative disorder 10.1
47 impulse control disorder 10.1
48 keratosis 10.1
49 cheilitis 10.1
50 hepatitis c 10.1

Comorbidity relations with Neurotic Excoriation via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Neurotic Excoriation:



Diseases related to Neurotic Excoriation

Symptoms & Phenotypes for Neurotic Excoriation

UMLS symptoms related to Neurotic Excoriation:


pruritus, pruritus ani, pruritus and related conditions, genital itching, other specified pruritic conditions

Drugs & Therapeutics for Neurotic Excoriation

Drugs for Neurotic Excoriation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamotrigine Approved, Investigational Phase 2 84057-84-1 3878
2 Sodium Channel Blockers Phase 2
3 Hormones Phase 2
4 Psychotropic Drugs Phase 2
5 Antipsychotic Agents Phase 2
6 Diuretics, Potassium Sparing Phase 2
7 Anticonvulsants Phase 2
8 Calcium, Dietary Phase 2
9 calcium channel blockers Phase 2
10
Calcium Nutraceutical Phase 2 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-Label Study of Lamictal In Neurotic Excoriation Completed NCT00269594 Phase 2 Lamictal (lamotrigine)
2 A Double-Blind Study of Lamictal in Neurotic Excoriation Completed NCT00513019 Phase 2 Lamictal (lamotrigine);Placebo

Search NIH Clinical Center for Neurotic Excoriation

Genetic Tests for Neurotic Excoriation

Anatomical Context for Neurotic Excoriation

MalaCards organs/tissues related to Neurotic Excoriation:

40
Skin

Publications for Neurotic Excoriation

Articles related to Neurotic Excoriation:

(show all 23)
# Title Authors PMID Year
1
Skin Picking Successfully Treated With Atomoxetine in Comorbid Skin Picking and Attention-Deficit/Hyperactivity Disorder: A Case Report. 61
32541332 2020
2
Repetitive Transcranial Magnetic Stimulation in the Treatment of Skin Picking Disorder: An Exploratory Trial. 61
31232909 2020
3
Obsessive-compulsive skin disorders: a novel classification based on degree of insight. 61
27658538 2017
4
Excoriation (skin-picking) disorder: a systematic review of treatment options. 61
28761349 2017
5
Psychiatric Features in Neurotic Excoriation Patients: The Role of Childhood Trauma. 61
28360736 2015
6
The reconstructive challenges and approach to patients with excoriation disorder. 61
25974792 2015
7
["Factitious disorder and skin picking: Clinical approach". A case report]. 61
24091067 2014
8
The influence of reduction mammaplasty on dermato-psychiatric disorders. 61
25610212 2012
9
Neurotic excoriations: a diagnosis of exclusion. 61
22468175 2012
10
Mucocutaneous disorders in children with down syndrome: case-controlled study. 61
22303799 2011
11
A double-blind, placebo-controlled trial of lamotrigine for pathological skin picking: treatment efficacy and neurocognitive predictors of response. 61
20531220 2010
12
Psycho-cutaneous disorders: an epidemiologic study. 61
19470079 2009
13
Psychocutaneous syndromes: a call for revised nomenclature. 61
17397356 2007
14
Treatment of facial scarring and ulceration resulting from acne excoriée with 585-nm pulsed dye laser irradiation and cognitive psychotherapy. 61
15171775 2004
15
Using hypnosis to facilitate resolution of psychogenic excoriations in acne excoriée. 61
15190729 2004
16
Phenomenology and therapeutic options for dermatotillomania. 61
19810989 2002
17
Psychogenic excoriation. Clinical features, proposed diagnostic criteria, epidemiology and approaches to treatment. 61
11475941 2001
18
A case of factitious skin disease. 61
11092276 2000
19
Under-diagnosed psychiatric syndrome. II: Pathologic skin picking. 61
10561770 1999
20
Dermacase. Neurotic excoriation. 61
8828870 1996
21
Skin picking as a symptom of body dysmorphic disorder. 61
7491380 1995
22
[Neurotic excoriation]. 61
1580435 1992
23
Dermatology and conditions related to obsessive-compulsive disorder. 61
1552059 1992

Variations for Neurotic Excoriation

Expression for Neurotic Excoriation

Search GEO for disease gene expression data for Neurotic Excoriation.

Pathways for Neurotic Excoriation

GO Terms for Neurotic Excoriation

Cellular components related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen trimer GO:0005581 9.16 COL7A1 COL17A1
2 basement membrane GO:0005604 9.13 DST COL7A1 COL17A1
3 hemidesmosome GO:0030056 8.62 DST COL17A1

Biological processes related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemidesmosome assembly GO:0031581 8.62 DST COL17A1

Molecular functions related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL7A1 COL17A1

Sources for Neurotic Excoriation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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