MCID: NRT002
MIFTS: 32

Neurotic Excoriation

Categories: Skin diseases, Neuronal diseases

Aliases & Classifications for Neurotic Excoriation

MalaCards integrated aliases for Neurotic Excoriation:

Name: Neurotic Excoriation 12 15
Factitious Skin Disease 12 73
Dermatitis Artefacta 12
Dermatitis Factitia 12
Dermatitis Ficta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9165
ICD10 33 L98.1
ICD9CM 35 698.4
UMLS 73 C1274184

Summaries for Neurotic Excoriation

MalaCards based summary : Neurotic Excoriation, also known as factitious skin disease, is related to kindler syndrome and epidermolysis bullosa dystrophica, and has symptoms including pruritus, pruritus ani and genital itching. An important gene associated with Neurotic Excoriation is SLITRK1 (SLIT And NTRK Like Family Member 1), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. The drugs Lamotrigine and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include skin.

Related Diseases for Neurotic Excoriation

Diseases related to Neurotic Excoriation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 kindler syndrome 10.3 COL7A1 DST
2 epidermolysis bullosa dystrophica 10.2 COL7A1 DST
3 dermatitis 10.2
4 lichen planus pemphigoides 10.2 COL17A1 DST
5 pemphigoid gestationis 10.2 COL17A1 DST
6 linear iga disease 10.2 COL17A1 DST
7 herpes gestationis 10.2 COL17A1 DST
8 epidermolysis bullosa simplex with muscular dystrophy 10.2 COL17A1 DST
9 autoimmune disease of skin and connective tissue 10.1 COL17A1 DST
10 lichen disease 10.1 COL17A1 DST
11 epidermolysis bullosa junctionalis with pyloric atresia 10.1 COL17A1 DST
12 cicatricial pemphigoid 10.1 COL17A1 DST
13 trichotillomania 10.1
14 bullous skin disease 10.1 COL17A1 DST
15 subcorneal pustular dermatosis 10.0 COL17A1 DST
16 paraneoplastic pemphigus 10.0 COL17A1 DST
17 junctional epidermolysis bullosa 10.0 COL17A1 DST
18 epidermolysis bullosa simplex 9.9 COL17A1 DST
19 hypersensitivity reaction disease 9.9 COL17A1 DST
20 kleine-levin hibernation syndrome 9.8 HTR7 KCNJ11
21 lichen planus 9.8 COL17A1 DST
22 vesiculobullous skin disease 9.7 COL17A1 COL7A1 DST
23 epidermolysis bullosa acquisita 9.7 COL17A1 COL7A1 DST
24 epidermolysis bullosa, junctional, non-herlitz type 9.7 COL17A1 COL7A1 DST
25 epidermolysis bullosa 9.7 COL17A1 COL7A1 DST
26 skin disease 9.7 COL17A1 COL7A1 DST
27 pemphigus 9.7 COL17A1 DST
28 ecthyma 9.5 COL17A1 DST KCNJ11
29 bullous pemphigoid 9.4 COL17A1 DST
30 kleptomania 9.4 HTR7 PPIG SLITRK1

Comorbidity relations with Neurotic Excoriation via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Neurotic Excoriation:



Diseases related to Neurotic Excoriation

Symptoms & Phenotypes for Neurotic Excoriation

UMLS symptoms related to Neurotic Excoriation:


pruritus, pruritus ani, genital itching, pruritus and related conditions, other specified pruritic conditions

Drugs & Therapeutics for Neurotic Excoriation

Drugs for Neurotic Excoriation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamotrigine Approved, Investigational Phase 2 84057-84-1 3878
2
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
3 calcium channel blockers Phase 2
4 Respiratory System Agents Phase 2
5 Sodium Channel Blockers Phase 2
6 Neurotransmitter Agents Phase 2
7 N-monoacetylcystine Phase 2
8 Diuretics, Potassium Sparing Phase 2
9 Excitatory Amino Acid Antagonists Phase 2
10 Excitatory Amino Acids Phase 2
11 Expectorants Phase 2
12 Anticonvulsants Phase 2
13 Antidotes Phase 2
14 Anti-Infective Agents Phase 2
15 Antioxidants Phase 2
16 Protective Agents Phase 2
17 Antiviral Agents Phase 2
18 Calcium, Dietary Phase 2
19 cysteine Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Double-Blind Lamictal (Lamotrigine) in Neurotic Excoriation Completed NCT00513019 Phase 2 Lamictal (lamotrigine);Placebo
2 An Open-Label Study Of Lamictal In Neurotic Excoriation Completed NCT00269594 Phase 2 Lamictal (lamotrigine)
3 N-Acetyl Cysteine in Pathologic Skin Picking Completed NCT01063348 Phase 2 N-Acetyl Cysteine;Placebo

Search NIH Clinical Center for Neurotic Excoriation

Genetic Tests for Neurotic Excoriation

Anatomical Context for Neurotic Excoriation

MalaCards organs/tissues related to Neurotic Excoriation:

41
Skin

Publications for Neurotic Excoriation

Articles related to Neurotic Excoriation:

# Title Authors Year
1
Psychiatric Features in Neurotic Excoriation Patients: The Role of Childhood Trauma. ( 28360736 )
2015
2
Neurotic excoriations and dermatitis artefacta. ( 24049967 )
2013
3
Primary psychiatric conditions: dermatitis artefacta, trichotillomania and neurotic excoriations. ( 23372212 )
2013
4
Dermacase. Neurotic excoriation. ( 8828870 )
1996

Variations for Neurotic Excoriation

Expression for Neurotic Excoriation

Search GEO for disease gene expression data for Neurotic Excoriation.

Pathways for Neurotic Excoriation

GO Terms for Neurotic Excoriation

Cellular components related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen trimer GO:0005581 9.16 COL17A1 COL7A1
2 hemidesmosome GO:0030056 8.96 COL17A1 DST
3 basement membrane GO:0005604 8.8 COL17A1 COL7A1 DST

Biological processes related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 8.62 COL17A1 COL7A1

Sources for Neurotic Excoriation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....