MCID: NRT002
MIFTS: 31

Neurotic Excoriation

Categories: Neuronal diseases, Skin diseases

Aliases & Classifications for Neurotic Excoriation

MalaCards integrated aliases for Neurotic Excoriation:

Name: Neurotic Excoriation 12 15 17
Factitious Skin Disease 12 70
Dermatitis Artefacta 12
Dermatitis Factitia 12
Dermatitis Ficta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9165
ICD9CM 34 698.4
SNOMED-CT 67 402736003
ICD10 32 L98.1
UMLS 70 C1274184

Summaries for Neurotic Excoriation

MalaCards based summary : Neurotic Excoriation, also known as factitious skin disease, is related to skin disease and pemphigoid, and has symptoms including pruritus, pruritus ani and pruritus and related conditions. An important gene associated with Neurotic Excoriation is COL7A1 (Collagen Type VII Alpha 1 Chain), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. The drugs Lamotrigine and Psychotropic Drugs have been mentioned in the context of this disorder. Affiliated tissues include skin.

Related Diseases for Neurotic Excoriation

Diseases related to Neurotic Excoriation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 skin disease 30.3 DST COL7A1 COL17A1
2 pemphigoid 30.3 DST COL17A1
3 epidermolysis bullosa 29.8 DST COL7A1 COL17A1
4 epidermolysis bullosa dystrophica 29.8 DST COL7A1 COL17A1
5 bullous pemphigoid 29.7 DST COL17A1
6 personality disorder 10.6
7 avoidant personality disorder 10.4
8 pyoderma 10.3
9 pyoderma gangrenosum 10.3
10 borderline personality disorder 10.3
11 factitious disorder 10.3
12 trichotillomania 10.2
13 cellulitis 10.2
14 vasculitis 10.2
15 nail disorder, nonsyndromic congenital, 9 10.2 COL7A1 COL17A1
16 nail disorder, nonsyndromic congenital, 4 10.1 COL7A1 COL17A1
17 dowling-degos disease 1 10.1
18 exanthem 10.1
19 multiple personality disorder 10.1
20 panniculitis 10.1
21 basal cell carcinoma 10.1
22 contact dermatitis 10.1
23 occupational dermatitis 10.1
24 headache 10.1
25 blepharocheilodontic syndrome 1 10.1 COL7A1 COL17A1
26 epidermolysis bullosa, junctional, herlitz type 10.1 COL7A1 COL17A1
27 lichen planus 10.1 DST COL17A1
28 lichen planus pemphigoides 10.1 DST COL17A1
29 linear iga disease 10.1 DST COL17A1
30 pompholyx 10.1 DST COL17A1
31 acute laryngopharyngitis 10.1 DST COL17A1
32 pemphigoid gestationis 10.1 DST COL17A1
33 dermatitis 10.1
34 subcorneal pustular dermatosis 10.1 DST COL17A1
35 vulvar dystrophy 10.1 DST COL17A1
36 paraneoplastic pemphigus 10.0 DST COL17A1
37 pemphigus 10.0 DST COL17A1
38 lichen disease 10.0 DST COL17A1
39 epidermolysis bullosa junctionalis with pyloric atresia 10.0 DST COL17A1
40 epidermolysis bullosa simplex with muscular dystrophy 10.0 DST COL17A1
41 recessive dystrophic epidermolysis bullosa 10.0 COL7A1 COL17A1
42 cicatricial pemphigoid 10.0 DST COL17A1
43 osteomyelitis 10.0
44 bullous skin disease 10.0 DST COL17A1
45 ainhum 10.0
46 alcohol dependence 10.0
47 attention deficit-hyperactivity disorder 10.0
48 porphyria cutanea tarda 10.0
49 schizophrenia 10.0
50 dermatitis, atopic 10.0

Comorbidity relations with Neurotic Excoriation via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Neurotic Excoriation:



Diseases related to Neurotic Excoriation

Symptoms & Phenotypes for Neurotic Excoriation

UMLS symptoms related to Neurotic Excoriation:


pruritus; pruritus ani; pruritus and related conditions; genital itching; other specified pruritic conditions

Drugs & Therapeutics for Neurotic Excoriation

Drugs for Neurotic Excoriation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamotrigine Approved, Investigational Phase 2 84057-84-1 3878
2 Psychotropic Drugs Phase 2
3 Sodium Channel Blockers Phase 2
4 Anticonvulsants Phase 2
5 Hormones Phase 2
6 Diuretics, Potassium Sparing Phase 2
7 Antipsychotic Agents Phase 2
8 Calcium, Dietary Phase 2
9 calcium channel blockers Phase 2
10
Calcium Nutraceutical Phase 2 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Double-Blind Study of Lamictal in Neurotic Excoriation Completed NCT00513019 Phase 2 Lamictal (lamotrigine);Placebo
2 An Open-Label Study of Lamictal In Neurotic Excoriation Completed NCT00269594 Phase 2 Lamictal (lamotrigine)

Search NIH Clinical Center for Neurotic Excoriation

Genetic Tests for Neurotic Excoriation

Anatomical Context for Neurotic Excoriation

MalaCards organs/tissues related to Neurotic Excoriation:

40
Skin

Publications for Neurotic Excoriation

Articles related to Neurotic Excoriation:

(show all 25)
# Title Authors PMID Year
1
N-acetylcysteine for managing neurotic excoriation: encouraging results in two patients. 61
33781651 2021
2
Report of Two Psychodermatological Cases: Neurotic Excoriation and Dermatitis Artefacta. 61
32970650 2020
3
Skin Picking Successfully Treated With Atomoxetine in Comorbid Skin Picking and Attention-Deficit/Hyperactivity Disorder: A Case Report. 61
32541332 2020
4
Repetitive Transcranial Magnetic Stimulation in the Treatment of Skin Picking Disorder: An Exploratory Trial. 61
31232909 2020
5
Obsessive-compulsive skin disorders: a novel classification based on degree of insight. 61
27658538 2017
6
Excoriation (skin-picking) disorder: a systematic review of treatment options. 61
28761349 2017
7
Psychiatric Features in Neurotic Excoriation Patients: The Role of Childhood Trauma. 61
28360736 2015
8
The reconstructive challenges and approach to patients with excoriation disorder. 61
25974792 2015
9
["Factitious disorder and skin picking: Clinical approach". A case report]. 61
24091067 2014
10
The influence of reduction mammaplasty on dermato-psychiatric disorders. 61
25610212 2012
11
Neurotic excoriations: a diagnosis of exclusion. 61
22468175 2012
12
Mucocutaneous disorders in children with down syndrome: case-controlled study. 61
22303799 2011
13
A double-blind, placebo-controlled trial of lamotrigine for pathological skin picking: treatment efficacy and neurocognitive predictors of response. 61
20531220 2010
14
Psycho-cutaneous disorders: an epidemiologic study. 61
19470079 2009
15
Psychocutaneous syndromes: a call for revised nomenclature. 61
17397356 2007
16
Treatment of facial scarring and ulceration resulting from acne excoriée with 585-nm pulsed dye laser irradiation and cognitive psychotherapy. 61
15171775 2004
17
Using hypnosis to facilitate resolution of psychogenic excoriations in acne excoriée. 61
15190729 2004
18
Phenomenology and therapeutic options for dermatotillomania. 61
19810989 2002
19
Psychogenic excoriation. Clinical features, proposed diagnostic criteria, epidemiology and approaches to treatment. 61
11475941 2001
20
A case of factitious skin disease. 61
11092276 2000
21
Under-diagnosed psychiatric syndrome. II: Pathologic skin picking. 61
10561770 1999
22
Dermacase. Neurotic excoriation. 61
8828870 1996
23
Skin picking as a symptom of body dysmorphic disorder. 61
7491380 1995
24
[Neurotic excoriation]. 61
1580435 1992
25
Dermatology and conditions related to obsessive-compulsive disorder. 61
1552059 1992

Variations for Neurotic Excoriation

Expression for Neurotic Excoriation

Search GEO for disease gene expression data for Neurotic Excoriation.

Pathways for Neurotic Excoriation

Pathways related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.86 DST COL7A1 COL17A1
2
Show member pathways
11.45 DST COL7A1 COL17A1

GO Terms for Neurotic Excoriation

Cellular components related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen trimer GO:0005581 9.16 COL7A1 COL17A1
2 basement membrane GO:0005604 9.13 DST COL7A1 COL17A1
3 hemidesmosome GO:0030056 8.62 DST COL17A1

Biological processes related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 8.96 COL7A1 COL17A1
2 hemidesmosome assembly GO:0031581 8.62 DST COL17A1

Molecular functions related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL7A1 COL17A1

Sources for Neurotic Excoriation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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