MCID: NRT002
MIFTS: 32

Neurotic Excoriation

Categories: Neuronal diseases, Skin diseases

Aliases & Classifications for Neurotic Excoriation

MalaCards integrated aliases for Neurotic Excoriation:

Name: Neurotic Excoriation 12 15
Factitious Skin Disease 12 73
Dermatitis Artefacta 12
Dermatitis Factitia 12
Dermatitis Ficta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9165
ICD10 33 L98.1
ICD9CM 35 698.4
SNOMED-CT 68 27720003
UMLS 73 C1274184

Summaries for Neurotic Excoriation

MalaCards based summary : Neurotic Excoriation, also known as factitious skin disease, is related to cellulitis and skin disease, and has symptoms including pruritus, pruritus ani and pruritus and related conditions. An important gene associated with Neurotic Excoriation is SLITRK1 (SLIT And NTRK Like Family Member 1), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. The drugs Lamotrigine and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells.

Related Diseases for Neurotic Excoriation

Diseases related to Neurotic Excoriation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 cellulitis 30.0 COL17A1 DST
2 skin disease 29.9 COL17A1 COL7A1 DST
3 epidermolysis bullosa 29.9 COL17A1 COL7A1 DST
4 dermatitis 10.3
5 porphyria cutanea tarda 10.2
6 raynaud disease 10.2
7 trichotillomania 10.2
8 porphyria 10.2
9 pyoderma 10.1
10 pyoderma gangrenosum 10.1
11 kindler syndrome 10.1 COL7A1 DST
12 bullous skin disease 10.1 COL17A1 DST
13 epidermolysis bullosa dystrophica 10.1 COL7A1 DST
14 lichen planus 10.1 COL17A1 DST
15 lichen planus pemphigoides 10.1 COL17A1 DST
16 pemphigoid gestationis 10.1 COL17A1 DST
17 linear iga disease 10.0 COL17A1 DST
18 herpes gestationis 10.0 COL17A1 DST
19 epidermolysis bullosa simplex with muscular dystrophy 10.0 COL17A1 DST
20 epidermolysis bullosa simplex 10.0 COL17A1 DST
21 autoimmune disease of skin and connective tissue 10.0 COL17A1 DST
22 lichen disease 10.0 COL17A1 DST
23 cicatricial pemphigoid 10.0 COL17A1 DST
24 epidermolysis bullosa junctionalis with pyloric atresia 10.0 COL17A1 DST
25 ainhum 10.0
26 attention deficit-hyperactivity disorder 10.0
27 schizophrenia 10.0
28 hepatitis c virus 10.0
29 hepatitis 10.0
30 keloids 10.0
31 lymphoma 10.0
32 cutaneous t cell lymphoma 10.0
33 borderline personality disorder 10.0
34 multiple personality disorder 10.0
35 dissociative disorder 10.0
36 impulse control disorder 10.0
37 personality disorder 10.0
38 panniculitis 10.0
39 hepatitis c 10.0
40 larynx cancer 10.0
41 purpura 10.0
42 syphilis 10.0
43 occupational dermatitis 10.0
44 tertiary syphilis 10.0
45 acquired hemophilia 10.0
46 dominant dystrophic epidermolysis bullosa 10.0
47 subcutaneous panniculitis-like t-cell lymphoma 10.0
48 subcorneal pustular dermatosis 10.0 COL17A1 DST
49 paraneoplastic pemphigus 10.0 COL17A1 DST
50 pemphigus 10.0 COL17A1 DST

Comorbidity relations with Neurotic Excoriation via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Neurotic Excoriation:



Diseases related to Neurotic Excoriation

Symptoms & Phenotypes for Neurotic Excoriation

UMLS symptoms related to Neurotic Excoriation:


pruritus, pruritus ani, pruritus and related conditions, genital itching, other specified pruritic conditions

Drugs & Therapeutics for Neurotic Excoriation

Drugs for Neurotic Excoriation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamotrigine Approved, Investigational Phase 2 84057-84-1 3878
2
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
3 Diuretics, Potassium Sparing Phase 2
4 Excitatory Amino Acid Antagonists Phase 2
5 Excitatory Amino Acids Phase 2
6 calcium channel blockers Phase 2
7 Anticonvulsants Phase 2
8 Sodium Channel Blockers Phase 2
9 Calcium, Dietary Phase 2
10 Neurotransmitter Agents Phase 2
11 Antiviral Agents Phase 2
12 Antioxidants Phase 2
13 Expectorants Phase 2
14 N-monoacetylcystine Phase 2
15 Anti-Infective Agents Phase 2
16 cysteine Phase 2
17 Free Radical Scavengers Phase 2
18 Respiratory System Agents Phase 2
19 Protective Agents Phase 2
20 Antidotes Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Double-Blind Lamictal (Lamotrigine) in Neurotic Excoriation Completed NCT00513019 Phase 2 Lamictal (lamotrigine);Placebo
2 An Open-Label Study Of Lamictal In Neurotic Excoriation Completed NCT00269594 Phase 2 Lamictal (lamotrigine)
3 N-Acetyl Cysteine in Pathologic Skin Picking Completed NCT01063348 Phase 2 N-Acetyl Cysteine;Placebo

Search NIH Clinical Center for Neurotic Excoriation

Genetic Tests for Neurotic Excoriation

Anatomical Context for Neurotic Excoriation

MalaCards organs/tissues related to Neurotic Excoriation:

41
Skin, T Cells

Publications for Neurotic Excoriation

Articles related to Neurotic Excoriation:

# Title Authors Year
1
Psychiatric Features in Neurotic Excoriation Patients: The Role of Childhood Trauma. ( 28360736 )
2015
2
A case of factitious skin disease. ( 11092276 )
2000
3
Dermacase. Neurotic excoriation. ( 8828870 )
1996

Variations for Neurotic Excoriation

Expression for Neurotic Excoriation

Search GEO for disease gene expression data for Neurotic Excoriation.

Pathways for Neurotic Excoriation

GO Terms for Neurotic Excoriation

Cellular components related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen trimer GO:0005581 9.16 COL17A1 COL7A1
2 hemidesmosome GO:0030056 8.96 COL17A1 DST
3 basement membrane GO:0005604 8.8 COL17A1 COL7A1 DST

Biological processes related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 8.96 COL17A1 COL7A1
2 hemidesmosome assembly GO:0031581 8.62 COL17A1 DST

Molecular functions related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL17A1 COL7A1

Sources for Neurotic Excoriation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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