MCID: NRT002
MIFTS: 32

Neurotic Excoriation

Categories: Neuronal diseases, Skin diseases

Aliases & Classifications for Neurotic Excoriation

MalaCards integrated aliases for Neurotic Excoriation:

Name: Neurotic Excoriation 12 15 17
Factitious Skin Disease 12 74
Dermatitis Artefacta 12
Dermatitis Factitia 12
Dermatitis Ficta 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9165
ICD9CM 36 698.4
SNOMED-CT 69 27720003
ICD10 34 L98.1
UMLS 74 C1274184

Summaries for Neurotic Excoriation

MalaCards based summary : Neurotic Excoriation, also known as factitious skin disease, is related to cellulitis and skin disease, and has symptoms including pruritus, pruritus ani and pruritus and related conditions. An important gene associated with Neurotic Excoriation is SLITRK1 (SLIT And NTRK Like Family Member 1), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. The drugs Lamotrigine and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include skin.

Related Diseases for Neurotic Excoriation

Diseases related to Neurotic Excoriation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 cellulitis 29.6 COL17A1 DST
2 skin disease 29.3 COL17A1 COL7A1 DST
3 epidermolysis bullosa 29.3 COL17A1 COL7A1 DST
4 dermatitis 10.3
5 porphyria cutanea tarda 10.2
6 raynaud disease 10.2
7 trichotillomania 10.2
8 keloids 10.2
9 porphyria 10.2
10 lymphoma 10.2
11 pyoderma 10.2
12 pyoderma gangrenosum 10.2
13 kleptomania 10.1 PPIG SLITRK1
14 ainhum 10.0
15 attention deficit-hyperactivity disorder 10.0
16 schizophrenia 10.0
17 hepatitis c virus 10.0
18 alopecia 10.0
19 hepatitis 10.0
20 pol iii-related leukodystrophies 10.0
21 cutaneous t cell lymphoma 10.0
22 borderline personality disorder 10.0
23 multiple personality disorder 10.0
24 dissociative disorder 10.0
25 impulse control disorder 10.0
26 personality disorder 10.0
27 panniculitis 10.0
28 hepatitis c 10.0
29 larynx cancer 10.0
30 purpura 10.0
31 syphilis 10.0
32 occupational dermatitis 10.0
33 tertiary syphilis 10.0
34 acquired hemophilia 10.0
35 dominant dystrophic epidermolysis bullosa 10.0
36 subcutaneous panniculitis-like t-cell lymphoma 10.0
37 kindler syndrome 9.9 COL7A1 DST
38 epidermolysis bullosa dystrophica 9.9 COL7A1 DST
39 bullous skin disease 9.8 COL17A1 DST
40 lichen planus 9.8 COL17A1 DST
41 lichen planus pemphigoides 9.8 COL17A1 DST
42 pemphigoid gestationis 9.8 COL17A1 DST
43 linear iga disease 9.8 COL17A1 DST
44 epidermolysis bullosa simplex 9.8 COL17A1 DST
45 epidermolysis bullosa simplex with muscular dystrophy 9.8 COL17A1 DST
46 autoimmune disease of skin and connective tissue 9.8 COL17A1 DST
47 lichen disease 9.8 COL17A1 DST
48 cicatricial pemphigoid 9.8 COL17A1 DST
49 ecthyma 9.7 COL17A1 DST
50 epidermolysis bullosa junctionalis with pyloric atresia 9.7 COL17A1 DST

Comorbidity relations with Neurotic Excoriation via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Neurotic Excoriation:



Diseases related to Neurotic Excoriation

Symptoms & Phenotypes for Neurotic Excoriation

UMLS symptoms related to Neurotic Excoriation:


pruritus, pruritus ani, pruritus and related conditions, genital itching, other specified pruritic conditions

Drugs & Therapeutics for Neurotic Excoriation

Drugs for Neurotic Excoriation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamotrigine Approved, Investigational Phase 2 84057-84-1 3878
2
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
3
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
4 Central Nervous System Depressants Phase 2
5 Hormones Phase 2
6 Psychotropic Drugs Phase 2
7 Sodium Channel Blockers Phase 2
8 calcium channel blockers Phase 2
9 Antipsychotic Agents Phase 2
10 Calcium, Dietary Phase 2
11 Diuretics, Potassium Sparing Phase 2
12 Anticonvulsants Phase 2
13 Tranquilizing Agents Phase 2
14 Expectorants Phase 2
15 N-monoacetylcystine Phase 2
16 Antidotes Phase 2
17 Antiviral Agents Phase 2
18 Antioxidants Phase 2
19 Free Radical Scavengers Phase 2
20 Anti-Infective Agents Phase 2
21 cysteine Phase 2
22 Respiratory System Agents Phase 2
23 Protective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Double-Blind Lamictal (Lamotrigine) in Neurotic Excoriation Completed NCT00513019 Phase 2 Lamictal (lamotrigine);Placebo
2 An Open-Label Study Of Lamictal In Neurotic Excoriation Completed NCT00269594 Phase 2 Lamictal (lamotrigine)
3 N-Acetyl Cysteine in Pathologic Skin Picking Completed NCT01063348 Phase 2 N-Acetyl Cysteine;Placebo

Search NIH Clinical Center for Neurotic Excoriation

Genetic Tests for Neurotic Excoriation

Anatomical Context for Neurotic Excoriation

MalaCards organs/tissues related to Neurotic Excoriation:

42
Skin

Publications for Neurotic Excoriation

Articles related to Neurotic Excoriation:

# Title Authors Year
1
Psychiatric Features in Neurotic Excoriation Patients: The Role of Childhood Trauma. ( 28360736 )
2015
2
Dermacase. Neurotic excoriation. ( 8828870 )
1996

Variations for Neurotic Excoriation

Expression for Neurotic Excoriation

Search GEO for disease gene expression data for Neurotic Excoriation.

Pathways for Neurotic Excoriation

GO Terms for Neurotic Excoriation

Cellular components related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.43 COL17A1 DST SLITRK1
2 collagen trimer GO:0005581 9.16 COL17A1 COL7A1
3 hemidesmosome GO:0030056 8.96 COL17A1 DST
4 basement membrane GO:0005604 8.8 COL17A1 COL7A1 DST

Biological processes related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.16 COL17A1 COL7A1
2 epidermis development GO:0008544 8.96 COL17A1 COL7A1
3 hemidesmosome assembly GO:0031581 8.62 COL17A1 DST

Molecular functions related to Neurotic Excoriation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL17A1 COL7A1

Sources for Neurotic Excoriation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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