MCID: NRT003
MIFTS: 19

Neurotrophic Keratoconjunctivitis

Categories: Neuronal diseases

Aliases & Classifications for Neurotrophic Keratoconjunctivitis

MalaCards integrated aliases for Neurotrophic Keratoconjunctivitis:

Name: Neurotrophic Keratoconjunctivitis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12125
ICD9CM 34 370.35
SNOMED-CT 67 77080005
ICD10 32 H16.23
UMLS 71 C0155084

Summaries for Neurotrophic Keratoconjunctivitis

MalaCards based summary : Neurotrophic Keratoconjunctivitis is related to adrenal gland pheochromocytoma and diabetic encephalopathy. An important gene associated with Neurotrophic Keratoconjunctivitis is LACTB (Lactamase Beta), and among its related pathways/superpathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Neural Stem Cells and Lineage-specific Markers. Related phenotypes are digestive/alimentary and vision/eye

Related Diseases for Neurotrophic Keratoconjunctivitis

Graphical network of the top 20 diseases related to Neurotrophic Keratoconjunctivitis:



Diseases related to Neurotrophic Keratoconjunctivitis

Symptoms & Phenotypes for Neurotrophic Keratoconjunctivitis

MGI Mouse Phenotypes related to Neurotrophic Keratoconjunctivitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.26 B4GALT1 BDNF MUC5AC PPT2
2 vision/eye MP:0005391 9.02 BDNF LACTB MUC5AC NGF PPT2

Drugs & Therapeutics for Neurotrophic Keratoconjunctivitis

Search Clinical Trials , NIH Clinical Center for Neurotrophic Keratoconjunctivitis

Genetic Tests for Neurotrophic Keratoconjunctivitis

Anatomical Context for Neurotrophic Keratoconjunctivitis

Publications for Neurotrophic Keratoconjunctivitis

Variations for Neurotrophic Keratoconjunctivitis

Expression for Neurotrophic Keratoconjunctivitis

Search GEO for disease gene expression data for Neurotrophic Keratoconjunctivitis.

Pathways for Neurotrophic Keratoconjunctivitis

Pathways related to Neurotrophic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.17 NGF BDNF
2 11.05 NGF BDNF
3
Show member pathways
10.78 NGF BDNF
4
Show member pathways
10.41 NGF BDNF

GO Terms for Neurotrophic Keratoconjunctivitis

Cellular components related to Neurotrophic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.62 NGF MUC5AC

Biological processes related to Neurotrophic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron differentiation GO:0045666 9.51 NGF BDNF
2 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.49 NGF BDNF
3 modulation of chemical synaptic transmission GO:0050804 9.48 NGF BDNF
4 memory GO:0007613 9.46 NGF BDNF
5 neuron projection morphogenesis GO:0048812 9.43 NGF BDNF
6 phosphatidylinositol-mediated signaling GO:0048015 9.4 NGF MUC5AC
7 regulation of neuron differentiation GO:0045664 9.37 NGF BDNF
8 peripheral nervous system development GO:0007422 9.32 NGF BDNF
9 neurotrophin TRK receptor signaling pathway GO:0048011 9.26 NGF BDNF
10 nerve development GO:0021675 9.16 NGF BDNF
11 nerve growth factor signaling pathway GO:0038180 8.96 NGF BDNF
12 positive regulation of collateral sprouting GO:0048672 8.62 NGF BDNF

Molecular functions related to Neurotrophic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nerve growth factor receptor binding GO:0005163 8.62 NGF BDNF

Sources for Neurotrophic Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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