MCID: NRT011
MIFTS: 32

Neurotrophic Keratopathy

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Neurotrophic Keratopathy

MalaCards integrated aliases for Neurotrophic Keratopathy:

Name: Neurotrophic Keratopathy 60
Neurotrophic Keratitis 60 74

Classifications:

Orphanet: 60  
Rare eye diseases


External Ids:

ICD10 via Orphanet 35 H16.2
UMLS via Orphanet 75 C0339296
Orphanet 60 ORPHA137596
UMLS 74 C0339296

Summaries for Neurotrophic Keratopathy

MalaCards based summary : Neurotrophic Keratopathy, also known as neurotrophic keratitis, is related to keratopathy and amyloidosis. An important gene associated with Neurotrophic Keratopathy is TAC1 (Tachykinin Precursor 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Mitogens and Ophthalmic Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and t cells.

Wikipedia : 77 Neurotrophic keratitis (NK) is a degenerative disease of the cornea caused by damage of the trigeminal... more...

Related Diseases for Neurotrophic Keratopathy

Graphical network of the top 20 diseases related to Neurotrophic Keratopathy:



Diseases related to Neurotrophic Keratopathy

Symptoms & Phenotypes for Neurotrophic Keratopathy

Drugs & Therapeutics for Neurotrophic Keratopathy

Drugs for Neurotrophic Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitogens Phase 4,Phase 1,Phase 2
2 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1
3 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
4 Lubricant Eye Drops Phase 4,Phase 1,Phase 2
5 Antioxidants Phase 2
6 Protective Agents Phase 2
7 Plasma-lyte 148 Phase 1, Phase 2
8 Anti-Bacterial Agents Phase 1, Phase 2
9 Anti-Infective Agents Phase 1, Phase 2
10
Methionine Approved, Nutraceutical Phase 1 63-68-3 6137

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis Not yet recruiting NCT02707120 Phase 4 PRGF-Endoret;Artificial tears eye-drops
2 Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer Completed NCT01794312 Phase 3
3 Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
4 Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 NK Completed NCT02227147 Phase 2 rhNGF 20µg/ml
5 Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. Completed NCT01756456 Phase 1, Phase 2 rhNGF 10 µg/ml eye drops solution;rhNGF 20 µg/ml eye drops solution;Placebo
6 A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2 Cord Blood Eye Drops;Conventional treatment
7 Study to Evaluate Safety, Tolerability & PK of rhNGF in Healthy Volunteers Completed NCT03836859 Phase 1 rhNGF 20μg/mL
8 Treatment of PED With AMT and Autologous Serum Completed NCT00238862 Not Applicable Autologous serum/BSS 20%
9 Miniinvasive Corneal Neurotization. A Pilot Study. Recruiting NCT03037450 Not Applicable

Search NIH Clinical Center for Neurotrophic Keratopathy

Genetic Tests for Neurotrophic Keratopathy

Anatomical Context for Neurotrophic Keratopathy

MalaCards organs/tissues related to Neurotrophic Keratopathy:

42
Eye, Brain, T Cells

Publications for Neurotrophic Keratopathy

Articles related to Neurotrophic Keratopathy:

(show top 50) (show all 102)
# Title Authors Year
1
Topical insulin in neurotrophic keratopathy after resection of acoustic neuroma. ( 30025986 )
2019
2
In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy. ( 30240004 )
2019
3
Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy. ( 30679185 )
2019
4
Post-herpes neurotrophic keratopathy: Aetiopathogenesis, clinical signs and current therapies. ( 30718014 )
2019
5
Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation. ( 30770356 )
2019
6
Re: Bonini et al.: Phase 2 randomized, double-masked, vehicle-controlled trial of recombinant human nerve growth factor for neurotrophic keratitis (Ophthalmology. 2018;125:1332-1343). ( 30683186 )
2019
7
Maxillary Zoster and Neurotrophic Keratitis following Trigeminal Block. ( 31097946 )
2019
8
Case Series: Management of Neurotrophic Keratitis from Familial Dysautonomia. ( 30063663 )
2018
9
In Vivo Confocal Microscopy Reveals Corneal Reinnervation After Treatment of Neurotrophic Keratopathy With Corneal Neurotization. ( 29053558 )
2018
10
Corneal Neurotization for Neurotrophic Keratopathy: Clinical Outcomes and In Vivo Confocal Microscopic and Histopathological Findings. ( 29373338 )
2018
11
Cerebellar Ataxia With Neuropathy and Vestibular Areflexia Syndrome Presenting With Neurotrophic Keratopathy. ( 29474200 )
2018
12
Vitamin B12 Deficiency as a Cause of Neurotrophic Keratopathy. ( 29541277 )
2018
13
A Case of Neurotrophic Keratopathy Associated with Nasopharyngeal Carcinoma. ( 29643792 )
2018
14
Neurotrophic keratopathy. ( 29698813 )
2018
15
A Case of Neurotrophic Keratopathy Concomitant to Brain Metastasis. ( 29755905 )
2018
16
Neurotrophic Keratopathy after Trigeminal Nerve Block for Treatment of Postherpetic Neuralgia. ( 29955409 )
2018
17
Corneal Neurotization Improves Ocular Surface Health in a Novel Rat Model of Neurotrophic Keratopathy and Corneal Neurotization. ( 30193306 )
2018
18
NEUROTROPHIC KERATOPATHY AFTER RETINAL DETACHMENT SURGERY COMBINED WITH ENDOLASER PHOTOCOAGULATION. ( 30300314 )
2018
19
Corneal neurotisation by great auricular nerve transfer and scleral-corneal tunnel incisions for neurotrophic keratopathy. ( 30470713 )
2018
20
Bilateral Candida parapsilosis infiltration of nonhealing indolent epithelial defects in a diabetic patient with neurotrophic keratopathy. ( 30502998 )
2018
21
Sphingomonas paucimobilis keratitis in a patient with neurotrophic keratopathy and severe neurosensory hypoacusis: Treatment with penetrating keratoplasty and amniotic membrane grafting. ( 30505128 )
2018
22
Asymptomatic neurotrophic keratitis in carotid-cavernous fistulae. ( 29369518 )
2018
23
Sural nerve graft for neurotrophic keratitis: early results. ( 29426435 )
2018
24
Phase II Randomized, Double-Masked, Vehicle-Controlled Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis. ( 29653858 )
2018
25
Phase I Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis. ( 29653861 )
2018
26
Neurotrophic keratitis: current challenges and future prospects. ( 29988739 )
2018
27
New Drug Treats Rare, Debilitating Neurotrophic Keratitis. ( 30285163 )
2018
28
Treatment of patients with neurotrophic keratitis stages 2 and 3 with plasma rich in growth factors (PRGF-Endoret) eye-drops. ( 28620707 )
2018
29
Neurotrophic keratopathy in a patient with familial amyloidosis. ( 28602432 )
2017
30
Neurotrophic Keratopathy: Therapeutic Approach Using a Novel Matrix Regenerating Agent. ( 28910175 )
2017
31
Cenegermin for the treatment of neurotrophic keratitis. ( 29451275 )
2017
32
Understanding the Pathogenesis of Neurotrophic Keratitis: The Role of Corneal Nerves. ( 27683068 )
2017
33
Neurotrophic keratitis secondary to cerebral malformation. ( 25976941 )
2017
34
Recessive Mutation in a Nuclear-Encoded Mitochondrial tRNA Synthetase Associated With Infantile Cataract, Congenital Neurotrophic Keratitis, and Orbital Myopathy. ( 27078007 )
2016
35
Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases. ( 27450739 )
2016
36
Ipsilateral supraorbital nerve transfer in a case of recalcitrant neurotrophic keratopathy with an intact ipsilateral frontal nerve: A novel surgical technique. ( 29503915 )
2016
37
Corrigendum to "Ipsilateral supraorbital nerve transfer in a case of recalcitrant neurotrophic keratopathy with an intact ipsilateral frontal nerve: A novel surgical technique" [Am J Ophthalmol Case Rep 4 2016 14-17]. ( 29505039 )
2016
38
Neurotrophic keratopathy secondary to trigeminal nerve aplasia in patient with Goldenhar syndrome. ( 26819096 )
2016
39
New therapies for neurotrophic keratitis. ( 26710658 )
2016
40
Neurotrophic keratitis after transscleral diode laser cyclophotocoagulation. ( 26810961 )
2016
41
Treatment of neurotrophic keratopathy with nicergoline. ( 25625360 )
2015
42
Etiologies, Quantitative Hypoesthesia, and Clinical Outcomes of Neurotrophic Keratopathy. ( 25828513 )
2015
43
Potential New Modes of Treatment of Neurotrophic Keratopathy. ( 26448169 )
2015
44
Synergistic effect of regenerating agent plus cord blood serum eye drops for the treatment of resistant neurotrophic keratitis: a case report and a hypothesis for pathophysiologic mechanism. ( 26586967 )
2015
45
Semaphorin 7a in Herpetic Neurotrophic Keratitis. ( 26241179 )
2015
46
Congenital Corneal Anesthesia and Neurotrophic Keratitis: Diagnosis and Management. ( 26451380 )
2015
47
Sclerokeratoplasty as the Therapy for Corneal Perforation due to Exposure and Neurotrophic Keratopathy. ( 24707423 )
2014
48
Intraocular involvement of T-cell lymphoma presenting as inflammatory glaucoma, neurotrophic keratopathy, and choroidal detachment. ( 24909374 )
2014
49
Neurotrophic keratopathy due to dorsolateral medullary infarction (Wallenberg syndrome): case report and literature review. ( 25472780 )
2014
50
Diagnosis and management of neurotrophic keratitis. ( 24672223 )
2014

Variations for Neurotrophic Keratopathy

Expression for Neurotrophic Keratopathy

Search GEO for disease gene expression data for Neurotrophic Keratopathy.

Pathways for Neurotrophic Keratopathy

Pathways related to Neurotrophic Keratopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 TAC1 TACR1
2 11.17 TAC1 TACR1
3 9.47 TAC1 TACR1

GO Terms for Neurotrophic Keratopathy

Biological processes related to Neurotrophic Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.32 TAC1 TACR1
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.26 TAC1 TACR1
3 response to pain GO:0048265 9.16 TAC1 TACR1
4 tachykinin receptor signaling pathway GO:0007217 8.96 TAC1 TACR1
5 detection of abiotic stimulus GO:0009582 8.62 TAC1 TACR1

Molecular functions related to Neurotrophic Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.32 CD160

Sources for Neurotrophic Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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