MCID: NRT011
MIFTS: 33

Neurotrophic Keratopathy

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Neurotrophic Keratopathy

MalaCards integrated aliases for Neurotrophic Keratopathy:

Name: Neurotrophic Keratopathy 59
Neurotrophic Keratitis 59 73

Classifications:

Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA137596
UMLS via Orphanet 74 C0339296
ICD10 via Orphanet 34 H16.2
UMLS 73 C0339296

Summaries for Neurotrophic Keratopathy

MalaCards based summary : Neurotrophic Keratopathy, also known as neurotrophic keratitis, is related to keratopathy and amyloidosis. An important gene associated with Neurotrophic Keratopathy is TAC1 (Tachykinin Precursor 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Ophthalmic Solutions and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and t cells.

Wikipedia : 76 Neurotrophic keratitis (NK) is a degenerative disease of the cornea caused by damage of the trigeminal... more...

Related Diseases for Neurotrophic Keratopathy

Graphical network of the top 20 diseases related to Neurotrophic Keratopathy:



Diseases related to Neurotrophic Keratopathy

Symptoms & Phenotypes for Neurotrophic Keratopathy

Drugs & Therapeutics for Neurotrophic Keratopathy

Drugs for Neurotrophic Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1
2 Mitogens Phase 4,Phase 1,Phase 2
3 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
4 Lubricant Eye Drops Phase 4,Phase 1,Phase 2
5 Protective Agents Phase 2
6 Antioxidants Phase 2
7 Plasma-lyte 148 Phase 1, Phase 2
8 Anti-Infective Agents Phase 1, Phase 2
9 Anti-Bacterial Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis Not yet recruiting NCT02707120 Phase 4 PRGF-Endoret;Artificial tears eye-drops
2 Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer Completed NCT01794312 Phase 3
3 Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
4 Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 NK Completed NCT02227147 Phase 2 rhNGF 20µg/ml
5 Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. Completed NCT01756456 Phase 1, Phase 2 rhNGF 10 µg/ml eye drops solution;rhNGF 20 µg/ml eye drops solution;Placebo
6 A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2 Cord Blood Eye Drops;Conventional treatment
7 Treatment of PED With AMT and Autologous Serum Completed NCT00238862 Not Applicable Autologous serum/BSS 20%
8 Miniinvasive Corneal Neurotization. A Pilot Study. Recruiting NCT03037450 Not Applicable

Search NIH Clinical Center for Neurotrophic Keratopathy

Genetic Tests for Neurotrophic Keratopathy

Anatomical Context for Neurotrophic Keratopathy

MalaCards organs/tissues related to Neurotrophic Keratopathy:

41
Eye, Brain, T Cells, Breast

Publications for Neurotrophic Keratopathy

Articles related to Neurotrophic Keratopathy:

(show top 50) (show all 97)
# Title Authors Year
1
A Case of Neurotrophic Keratopathy Associated with Nasopharyngeal Carcinoma. ( 29643792 )
2018
2
Cerebellar Ataxia With Neuropathy and Vestibular Areflexia Syndrome Presenting With Neurotrophic Keratopathy. ( 29474200 )
2018
3
Corneal Neurotization for Neurotrophic Keratopathy: Clinical Outcomes and In Vivo Confocal Microscopic and Histopathological Findings. ( 29373338 )
2018
4
Neurotrophic Keratopathy after Trigeminal Nerve Block for Treatment of Postherpetic Neuralgia. ( 29955409 )
2018
5
A Case of Neurotrophic Keratopathy Concomitant to Brain Metastasis. ( 29755905 )
2018
6
In Vivo Confocal Microscopy Reveals Corneal Reinnervation After Treatment of Neurotrophic Keratopathy With Corneal Neurotization. ( 29053558 )
2018
7
Vitamin B12 Deficiency as a Cause of Neurotrophic Keratopathy. ( 29541277 )
2018
8
Neurotrophic keratopathy. ( 29698813 )
2018
9
Topical insulin in neurotrophic keratopathy after resection of acoustic neuroma. ( 30025986 )
2018
10
Case Series: Management of Neurotrophic Keratitis from Familial Dysautonomia. ( 30063663 )
2018
11
Corneal Neurotization Improves Ocular Surface Health in a Novel Rat Model of Neurotrophic Keratopathy and Corneal Neurotization. ( 30193306 )
2018
12
In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy. ( 30240004 )
2018
13
NEUROTROPHIC KERATOPATHY AFTER RETINAL DETACHMENT SURGERY COMBINED WITH ENDOLASER PHOTOCOAGULATION. ( 30300314 )
2018
14
Corneal neurotisation by great auricular nerve transfer and scleral-corneal tunnel incisions for neurotrophic keratopathy. ( 30470713 )
2018
15
Bilateral Candida parapsilosis infiltration of nonhealing indolent epithelial defects in a diabetic patient with neurotrophic keratopathy. ( 30502998 )
2018
16
Sphingomonas paucimobilis keratitis in a patient with neurotrophic keratopathy and severe neurosensory hypoacusis: Treatment with penetrating keratoplasty and amniotic membrane grafting. ( 30505128 )
2018
17
Sural nerve graft for neurotrophic keratitis: early results. ( 29426435 )
2018
18
Phase II Randomized, Double-Masked, Vehicle-Controlled Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis. ( 29653858 )
2018
19
Phase I Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis. ( 29653861 )
2018
20
Neurotrophic keratitis: current challenges and future prospects. ( 29988739 )
2018
21
New Drug Treats Rare, Debilitating Neurotrophic Keratitis. ( 30285163 )
2018
22
Treatment of patients with neurotrophic keratitis stages 2 and 3 with plasma rich in growth factors (PRGF-Endoret) eye-drops. ( 28620707 )
2018
23
Asymptomatic neurotrophic keratitis in carotid-cavernous fistulae. ( 29369518 )
2018
24
Neurotrophic Keratopathy: Therapeutic Approach Using a Novel Matrix Regenerating Agent. ( 28910175 )
2017
25
Neurotrophic keratopathy in a patient with familial amyloidosis. ( 28602432 )
2017
26
Cenegermin for the treatment of neurotrophic keratitis. ( 29451275 )
2017
27
Understanding the Pathogenesis of Neurotrophic Keratitis: The Role of Corneal Nerves. ( 27683068 )
2017
28
Neurotrophic keratitis secondary to cerebral malformation. ( 25976941 )
2017
29
Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases. ( 27450739 )
2016
30
Ipsilateral supraorbital nerve transfer in a case of recalcitrant neurotrophic keratopathy with an intact ipsilateral frontal nerve: A novel surgical technique. ( 29503915 )
2016
31
Recessive Mutation in a Nuclear-Encoded Mitochondrial tRNA Synthetase Associated With Infantile Cataract, Congenital Neurotrophic Keratitis, and Orbital Myopathy. ( 27078007 )
2016
32
Neurotrophic keratopathy secondary to trigeminal nerve aplasia in patient with Goldenhar syndrome. ( 26819096 )
2016
33
Corrigendum to "Ipsilateral supraorbital nerve transfer in a case of recalcitrant neurotrophic keratopathy with an intact ipsilateral frontal nerve: A novel surgical technique" [Am J Ophthalmol Case Rep 4 2016 14-17]. ( 29505039 )
2016
34
New therapies for neurotrophic keratitis. ( 26710658 )
2016
35
Neurotrophic keratitis after transscleral diode laser cyclophotocoagulation. ( 26810961 )
2016
36
Etiologies, Quantitative Hypoesthesia, and Clinical Outcomes of Neurotrophic Keratopathy. ( 25828513 )
2015
37
Potential New Modes of Treatment of Neurotrophic Keratopathy. ( 26448169 )
2015
38
Treatment of neurotrophic keratopathy with nicergoline. ( 25625360 )
2015
39
Semaphorin 7a in Herpetic Neurotrophic Keratitis. ( 26241179 )
2015
40
Congenital Corneal Anesthesia and Neurotrophic Keratitis: Diagnosis and Management. ( 26451380 )
2015
41
Synergistic effect of regenerating agent plus cord blood serum eye drops for the treatment of resistant neurotrophic keratitis: a case report and a hypothesis for pathophysiologic mechanism. ( 26586967 )
2015
42
Neurotrophic keratopathy due to dorsolateral medullary infarction (Wallenberg syndrome): case report and literature review. ( 25472780 )
2014
43
Sclerokeratoplasty as the Therapy for Corneal Perforation due to Exposure and Neurotrophic Keratopathy. ( 24707423 )
2014
44
Intraocular involvement of T-cell lymphoma presenting as inflammatory glaucoma, neurotrophic keratopathy, and choroidal detachment. ( 24909374 )
2014
45
Diagnosis and management of neurotrophic keratitis. ( 24672223 )
2014
46
A Comparison of the Efficacy of Autologous Serum Eye Drops with Amniotic Membrane Transplantation in Neurotrophic Keratitis. ( 23758337 )
2013
47
Neurotrophic Keratitis. ( 24107451 )
2013
48
Metaherpetic corneal disease in a dog associated with partial limbal stem cell deficiency and neurotrophic keratitis. ( 22958361 )
2013
49
Corneal changes in neurosurgically induced neurotrophic keratitis. ( 24158681 )
2013
50
Scleral contact lenses as an alternative to tarsorrhaphy for the long-term management of combined exposure and neurotrophic keratopathy. ( 23073486 )
2013

Variations for Neurotrophic Keratopathy

Expression for Neurotrophic Keratopathy

Search GEO for disease gene expression data for Neurotrophic Keratopathy.

Pathways for Neurotrophic Keratopathy

Pathways related to Neurotrophic Keratopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 TAC1 TACR1
2 11.17 TAC1 TACR1
3 9.47 TAC1 TACR1

GO Terms for Neurotrophic Keratopathy

Biological processes related to Neurotrophic Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.32 TAC1 TACR1
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.26 TAC1 TACR1
3 response to pain GO:0048265 9.16 TAC1 TACR1
4 tachykinin receptor signaling pathway GO:0007217 8.96 TAC1 TACR1
5 detection of abiotic stimulus GO:0009582 8.62 TAC1 TACR1

Molecular functions related to Neurotrophic Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.62 CD160 TAC1

Sources for Neurotrophic Keratopathy

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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
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31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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37 KEGG
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45 MESH via Orphanet
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54 NINDS
55 Novoseek
57 OMIM
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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