MCID: NRT011
MIFTS: 33

Neurotrophic Keratopathy

Categories: Eye diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Neurotrophic Keratopathy

MalaCards integrated aliases for Neurotrophic Keratopathy:

Name: Neurotrophic Keratopathy 59
Neurotrophic Keratitis 59 73

Classifications:

Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA137596
UMLS via Orphanet 74 C0339296
ICD10 via Orphanet 34 H16.2
UMLS 73 C0339296

Summaries for Neurotrophic Keratopathy

MalaCards based summary : Neurotrophic Keratopathy, also known as neurotrophic keratitis, is related to keratopathy and amyloidosis. An important gene associated with Neurotrophic Keratopathy is TAC1 (Tachykinin Precursor 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Ephedrine and Pseudoephedrine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and t cells.

Wikipedia : 76 Neurotrophic keratitis (NK) is a degenerative disease of the cornea caused by damage of the trigeminal... more...

Related Diseases for Neurotrophic Keratopathy

Diseases related to Neurotrophic Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 keratopathy 10.6
2 amyloidosis 9.9
3 hereditary sensory neuropathy 9.9
4 sensory peripheral neuropathy 9.9
5 hemifacial microsomia with radial defects 9.8
6 hemifacial microsomia 9.8
7 hereditary amyloidosis 9.8
8 insulin-like growth factor i 9.8
9 postherpetic neuralgia 9.8
10 aceruloplasminemia 9.8
11 nasopharyngeal carcinoma 9.8
12 ataxia-oculomotor apraxia 3 9.8
13 diabetes mellitus 9.8
14 vitamin b12 deficiency 9.8
15 lymphoma 9.8
16 nasopharyngitis 9.8
17 choroiditis 9.8
18 herpes zoster 9.8
19 neuropathy 9.8
20 retinitis pigmentosa 68 9.7 TAC1 TACR1
21 perry syndrome 9.7 TAC1 TACR1
22 cystitis 9.6 TAC1 TACR1
23 constipation 9.5 TAC1 TACR1
24 migraine with or without aura 1 9.2 TAC1 TACR1

Graphical network of the top 20 diseases related to Neurotrophic Keratopathy:



Diseases related to Neurotrophic Keratopathy

Symptoms & Phenotypes for Neurotrophic Keratopathy

Drugs & Therapeutics for Neurotrophic Keratopathy

Drugs for Neurotrophic Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ephedrine Approved Phase 4,Phase 1,Phase 2 299-42-3 9294
2
Pseudoephedrine Approved Phase 4,Phase 1,Phase 2 90-82-4 7028
3 Mitogens Phase 4,Phase 2,Phase 1
4 Tetrahydrozoline Phase 4,Phase 3,Phase 2,Phase 1
5 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1
6 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
7 Respiratory System Agents Phase 4,Phase 1,Phase 2
8 Nasal Decongestants Phase 4,Phase 1,Phase 2
9 Vasoconstrictor Agents Phase 4,Phase 1,Phase 2
10 Peripheral Nervous System Agents Phase 4,Phase 1,Phase 2
11 Autonomic Agents Phase 4,Phase 1,Phase 2
12 Lubricant Eye Drops Phase 4,Phase 1,Phase 2
13 Antioxidants Phase 2
14 Protective Agents Phase 2
15 Anti-Bacterial Agents Phase 1, Phase 2
16 Plasma-lyte 148 Phase 1, Phase 2
17 Anti-Infective Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis Not yet recruiting NCT02707120 Phase 4 PRGF-Endoret;Artificial tears eye-drops
2 Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
3 Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer Active, not recruiting NCT01794312 Phase 3
4 Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 Neurotrophic Keratitis Unknown status NCT02227147 Phase 2 rhNGF 20µg/ml;Placebo Vehicle
5 Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. Completed NCT01756456 Phase 1, Phase 2 rhNGF 10 µg/ml eye drops solution;rhNGF 20 µg/ml eye drops solution;Placebo
6 A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2 Cord Blood Eye Drops;Conventional treatment
7 Treatment of PED With AMT and Autologous Serum Completed NCT00238862 Not Applicable Autologous serum/BSS 20%
8 Miniinvasive Corneal Neurotization. A Pilot Study. Recruiting NCT03037450 Not Applicable

Search NIH Clinical Center for Neurotrophic Keratopathy

Genetic Tests for Neurotrophic Keratopathy

Anatomical Context for Neurotrophic Keratopathy

MalaCards organs/tissues related to Neurotrophic Keratopathy:

41
Eye, Brain, T Cells

Publications for Neurotrophic Keratopathy

Articles related to Neurotrophic Keratopathy:

(show top 50) (show all 55)
# Title Authors Year
1
A Case of Neurotrophic Keratopathy Associated with Nasopharyngeal Carcinoma. ( 29643792 )
2018
2
Cerebellar Ataxia With Neuropathy and Vestibular Areflexia Syndrome Presenting With Neurotrophic Keratopathy. ( 29474200 )
2018
3
Corneal Neurotization for Neurotrophic Keratopathy: Clinical Outcomes and In Vivo Confocal Microscopic and Histopathological Findings. ( 29373338 )
2018
4
Neurotrophic Keratopathy after Trigeminal Nerve Block for Treatment of Postherpetic Neuralgia. ( 29955409 )
2018
5
A Case of Neurotrophic Keratopathy Concomitant to Brain Metastasis. ( 29755905 )
2018
6
In Vivo Confocal Microscopy Reveals Corneal Reinnervation After Treatment of Neurotrophic Keratopathy With Corneal Neurotization. ( 29053558 )
2018
7
Vitamin B12 Deficiency as a Cause of Neurotrophic Keratopathy. ( 29541277 )
2018
8
Neurotrophic keratopathy. ( 29698813 )
2018
9
Neurotrophic Keratopathy: Therapeutic Approach Using a Novel Matrix Regenerating Agent. ( 28910175 )
2017
10
Neurotrophic keratopathy in a patient with familial amyloidosis. ( 28602432 )
2017
11
Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases. ( 27450739 )
2016
12
Ipsilateral supraorbital nerve transfer in a case of recalcitrant neurotrophic keratopathy with an intact ipsilateral frontal nerve: A novel surgical technique. ( 29503915 )
2016
13
Recessive Mutation in a Nuclear-Encoded Mitochondrial tRNA Synthetase Associated With Infantile Cataract, Congenital Neurotrophic Keratitis, and Orbital Myopathy. ( 27078007 )
2016
14
Neurotrophic keratopathy secondary to trigeminal nerve aplasia in patient with Goldenhar syndrome. ( 26819096 )
2016
15
Corrigendum to "Ipsilateral supraorbital nerve transfer in a case of recalcitrant neurotrophic keratopathy with an intact ipsilateral frontal nerve: A novel surgical technique" [Am J Ophthalmol Case Rep 4 2016 14-17]. ( 29505039 )
2016
16
Etiologies, Quantitative Hypoesthesia, and Clinical Outcomes of Neurotrophic Keratopathy. ( 25828513 )
2015
17
Potential New Modes of Treatment of Neurotrophic Keratopathy. ( 26448169 )
2015
18
Treatment of neurotrophic keratopathy with nicergoline. ( 25625360 )
2015
19
Neurotrophic keratopathy due to dorsolateral medullary infarction (Wallenberg syndrome): case report and literature review. ( 25472780 )
2014
20
Intraocular involvement of T-cell lymphoma presenting as inflammatory glaucoma, neurotrophic keratopathy, and choroidal detachment. ( 24909374 )
2014
21
Sclerokeratoplasty as the Therapy for Corneal Perforation due to Exposure and Neurotrophic Keratopathy. ( 24707423 )
2014
22
A Comparison of the Efficacy of Autologous Serum Eye Drops with Amniotic Membrane Transplantation in Neurotrophic Keratitis. ( 23758337 )
2013
23
Neurotrophic Keratitis. ( 24107451 )
2013
24
Metaherpetic corneal disease in a dog associated with partial limbal stem cell deficiency and neurotrophic keratitis. ( 22958361 )
2013
25
Corneal changes in neurosurgically induced neurotrophic keratitis. ( 24158681 )
2013
26
Bilateral nerve alterations in a unilateral experimental neurotrophic keratopathy model: a lateral conjunctival approach for trigeminal axotomy. ( 23967133 )
2013
27
Scleral contact lenses as an alternative to tarsorrhaphy for the long-term management of combined exposure and neurotrophic keratopathy. ( 23073486 )
2013
28
Scleral contact lens management of bilateral exposure and neurotrophic keratopathy. ( 22902053 )
2012
29
Neurotrophic keratitis and congenital insensitivity to pain with anhidrosis--a case report with 10-year follow-up. ( 20847675 )
2011
30
Bilateral herpetic keratitis presenting with unilateral neurotrophic keratitis in pemphigus foliaceus: a case report. ( 21794135 )
2011
31
A novel mouse model for neurotrophic keratopathy: trigeminal nerve stereotactic electrolysis through the brain. ( 21071731 )
2011
32
Neurotrophic keratopathy; its pathophysiology and treatment. ( 20376784 )
2010
33
Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy. ( 19965821 )
2010
34
Advances in treatment for neurotrophic keratopathy. ( 19537364 )
2009
35
Corneal neurotization: a novel solution to neurotrophic keratopathy. ( 19116544 )
2009
36
Amyloidosis-associated neurotrophic keratopathy precipitated by overcorrected blepharoptosis. ( 19421037 )
2009
37
Boston keratoprosthesis treatment of herpes zoster neurotrophic keratopathy. ( 18243928 )
2008
38
Open clinical study of eye-drops containing tetrapeptides derived from substance P and insulin-like growth factor-1 for treatment of persistent corneal epithelial defects associated with neurotrophic keratopathy. ( 18511539 )
2008
39
Persistent epithelial defects due to neurotrophic keratopathy treated with a substance p-derived peptide and insulin-like growth factor 1. ( 18158595 )
2007
40
Neurotrophic keratopathy and diabetes mellitus. ( 16215544 )
2006
41
Therapeutic options for the management of early neurotrophic keratopathy: a case report and review. ( 17000411 )
2006
42
New insights into the diagnosis and treatment of neurotrophic keratopathy. ( 17131013 )
2005
43
Treatment of neurotrophic keratopathy with nasal dilator strips. ( 16234466 )
2005
44
Autologous serum application in the treatment of neurotrophic keratopathy. ( 15177961 )
2004
45
Management of neurotrophic keratopathy. ( 16303512 )
2003
46
Restoration of corneal epithelial barrier function and wound healing by substance P and IGF-1 in rats with capsaicin-induced neurotrophic keratopathy. ( 12824234 )
2003
47
Effects of substance P and IGF-1 in corneal epithelial barrier function and wound healing in a rat model of neurotrophic keratopathy. ( 12939296 )
2003
48
Neurotrophic keratopathy. ( 11352446 )
2001
49
Bilateral neurotrophic keratopathy complicating Vidian neurectomy. ( 11438063 )
2001
50
Direct observation of corneal nerve fibres in neurotrophic keratopathy by confocal biomicroscopy. ( 10560682 )
1999

Variations for Neurotrophic Keratopathy

Expression for Neurotrophic Keratopathy

Search GEO for disease gene expression data for Neurotrophic Keratopathy.

Pathways for Neurotrophic Keratopathy

Pathways related to Neurotrophic Keratopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 TAC1 TACR1
2 11.17 TAC1 TACR1
3 9.47 TAC1 TACR1

GO Terms for Neurotrophic Keratopathy

Biological processes related to Neurotrophic Keratopathy according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.61 TAC1 TACR1
2 cell surface receptor signaling pathway GO:0007166 9.6 CD160 TACR1
3 chemical synaptic transmission GO:0007268 9.59 TAC1 TACR1
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.58 TAC1 TACR1
5 regulation of blood pressure GO:0008217 9.58 TAC1 TACR1
6 response to hormone GO:0009725 9.57 TAC1 TACR1
7 sensory perception of pain GO:0019233 9.56 TAC1 TACR1
8 positive regulation of stress fiber assembly GO:0051496 9.55 TAC1 TACR1
9 positive regulation of epithelial cell migration GO:0010634 9.54 TAC1 TACR1
10 long-term memory GO:0007616 9.52 TAC1 TACR1
11 response to morphine GO:0043278 9.51 TAC1 TACR1
12 associative learning GO:0008306 9.49 TAC1 TACR1
13 response to pain GO:0048265 9.48 TAC1 TACR1
14 positive regulation of ossification GO:0045778 9.46 TAC1 TACR1
15 positive regulation of renal sodium excretion GO:0035815 9.43 TAC1 TACR1
16 positive regulation of synaptic transmission, GABAergic GO:0032230 9.4 TAC1 TACR1
17 positive regulation of lymphocyte proliferation GO:0050671 9.37 TAC1 TACR1
18 tachykinin receptor signaling pathway GO:0007217 9.32 TAC1 TACR1
19 positive regulation of action potential GO:0045760 9.26 TAC1 TACR1
20 detection of abiotic stimulus GO:0009582 9.16 TAC1 TACR1
21 positive regulation of saliva secretion GO:0046878 8.96 TAC1 TACR1
22 positive regulation of synaptic transmission, cholinergic GO:0032224 8.62 TAC1 TACR1

Molecular functions related to Neurotrophic Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.62 CD160 TAC1

Sources for Neurotrophic Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....