MCID: NRT011
MIFTS: 37

Neurotrophic Keratopathy

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Neurotrophic Keratopathy

MalaCards integrated aliases for Neurotrophic Keratopathy:

Name: Neurotrophic Keratopathy 58
Neurotrophic Keratitis 58 71

Classifications:

Orphanet: 58  
Rare eye diseases


External Ids:

ICD10 via Orphanet 33 H16.2
UMLS via Orphanet 72 C0339296
Orphanet 58 ORPHA137596
UMLS 71 C0339296

Summaries for Neurotrophic Keratopathy

MalaCards based summary : Neurotrophic Keratopathy, also known as neurotrophic keratitis, is related to keratopathy and keratitis, hereditary. An important gene associated with Neurotrophic Keratopathy is CD160 (CD160 Molecule), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Mitogens and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and breast, and related phenotypes are decreased corneal sensation and abnormal fifth cranial nerve morphology

Wikipedia : 74 Neurotrophic keratitis (NK) is a degenerative disease of the cornea caused by damage of the trigeminal... more...

Related Diseases for Neurotrophic Keratopathy

Diseases related to Neurotrophic Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 keratopathy 30.9 TACR1 TAC1
2 keratitis, hereditary 10.4
3 corneal disease 10.4
4 corneal ulcer 10.2
5 acoustic neuroma 10.2
6 lagophthalmos 10.2
7 neuroma 10.2
8 sensory peripheral neuropathy 10.1
9 meningioma, radiation-induced 10.1
10 meningioma, familial 10.1
11 ptosis 10.1
12 spinal meningioma 10.1
13 facial paralysis 10.1
14 secretory meningioma 10.1
15 lymphoplasmacyte-rich meningioma 10.1
16 herpes zoster 10.1
17 herpes simplex 10.1
18 chickenpox 10.1
19 neuropathy 10.1
20 amyloidosis 10.1
21 blepharitis 10.1
22 exposure keratitis 10.1
23 herpes zoster ophthalmicus 10.1
24 trigeminal neuralgia 10.1
25 hereditary sensory neuropathy 10.1
26 eye disease 10.1
27 autoimmune disease 9.9
28 hemifacial microsomia 9.9
29 retinal detachment 9.9
30 insulin-like growth factor i 9.9
31 ataxia and polyneuropathy, adult-onset 9.9
32 pars planitis 9.9
33 nasopharyngeal carcinoma 9.9
34 intraocular pressure quantitative trait locus 9.9
35 synesthesia 9.9
36 vitamin b12 deficiency 9.9
37 peripheral t-cell lymphoma 9.9
38 lymphoma 9.9
39 dry eye syndrome 9.9
40 hypopyon ulcer 9.9
41 hypopyon 9.9
42 corneal edema 9.9
43 corneal neovascularization 9.9
44 corneal degeneration 9.9
45 keratoconjunctivitis sicca 9.9
46 uveitis 9.9
47 mature cataract 9.9
48 polyneuropathy 9.9
49 ectropion 9.9
50 neurilemmoma 9.9

Graphical network of the top 20 diseases related to Neurotrophic Keratopathy:



Diseases related to Neurotrophic Keratopathy

Symptoms & Phenotypes for Neurotrophic Keratopathy

Human phenotypes related to Neurotrophic Keratopathy:

58 31 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 decreased corneal sensation 58 31 hallmark (90%) Very frequent (99-80%) HP:0012155
2 abnormal fifth cranial nerve morphology 58 31 hallmark (90%) Very frequent (99-80%) HP:0010824
3 slow decrease in visual acuity 58 31 frequent (33%) Frequent (79-30%) HP:0007924
4 diabetes mellitus 58 31 occasional (7.5%) Occasional (29-5%) HP:0000819
5 lacrimation abnormality 58 31 occasional (7.5%) Occasional (29-5%) HP:0000632
6 corneal ulceration 58 31 occasional (7.5%) Occasional (29-5%) HP:0012804
7 astigmatism 58 31 occasional (7.5%) Occasional (29-5%) HP:0000483
8 corneal scarring 58 31 occasional (7.5%) Occasional (29-5%) HP:0000559
9 blurred vision 58 31 occasional (7.5%) Occasional (29-5%) HP:0000622
10 recurrent corneal erosions 58 31 occasional (7.5%) Occasional (29-5%) HP:0000495
11 anterior uveitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012122
12 corneal stromal edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0012040
13 hyperesthesia 58 31 very rare (1%) Very rare (<4-1%) HP:0100963
14 corneal perforation 58 31 very rare (1%) Very rare (<4-1%) HP:0100583
15 allodynia 58 31 very rare (1%) Very rare (<4-1%) HP:0012533

Drugs & Therapeutics for Neurotrophic Keratopathy

Drugs for Neurotrophic Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitogens Phase 1, Phase 2
2 Antioxidants Phase 2
3 Pharmaceutical Solutions Phase 1, Phase 2
4 Ophthalmic Solutions Phase 1, Phase 2
5 Lubricant Eye Drops Phase 1, Phase 2
6 Anti-Bacterial Agents Phase 1, Phase 2
7 Anti-Infective Agents Phase 1, Phase 2
8 Plasma-lyte 148 Phase 1, Phase 2
9
Sodium citrate Approved, Investigational 68-04-2
10
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
11 Citrate

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Randomized, Parallel Groups, Multicenter and Blind to Evaluators Clinical Trial, to Evaluate the Efficacy and Safety of PRGF-Endoret Eye Drops, in Patients With Stage 2 and 3 Neurotrophic Keratitis Unknown status NCT02707120 Phase 4 PRGF-Endoret;Artificial tears eye-drops
2 Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer Completed NCT01794312 Phase 3
3 Phase 3, Multi-Center, Randomized, Double Masked, Placebo Controlled Clinical Study to Assess the Safety and Efficacy of RGN-259 Ophthalmic Solution for the Treatment of Neurotrophic Keratopathy: SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
4 An 8-week Phase II, Multicenter, Randomized, Double-masked, Vehicle Controlled Parallel Group Study With a 24 or 32 Week Follow-up to Evaluate the Efficacy of rhNGF 20 µg/ml vs Vehicle in Patients With Stage 2 and 3 Neurotrophic Keratitis Completed NCT02227147 Phase 2 rhNGF 20µg/ml
5 An 8-week Phase I/II, Multicenter, Randomized, Double-masked, Vehicle Controlled Parallel Group Study to Evaluate the Safety and Efficacy of Two Doses of Recombinant Human Nerve Growth Factor in Patients With Stage 2 and 3 of NK Completed NCT01756456 Phase 1, Phase 2 rhNGF 10 μg/ml;rhNGF 20 μg/ml
6 Safety and Feasibility of Cultivated Autologous Limbal Epithelial Cell Transplantation in the Treatment of Limbal Stem Cell Deficiency (LSCD) Recruiting NCT02592330 Phase 1, Phase 2
7 A Multicenter, Randomized, Open-label, Two-arms Phase I/II Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2 Cord Blood Eye Drops;Conventional treatment
8 Efficacy, Safety and Pharmacokinetics of 3 Doses of REC 0/0559 Eye Drops for the Treatment of Stage 2 (Moderate) and 3 (Severe) Neurotrophic Keratitis in Adult Patients Not yet recruiting NCT04276558 Phase 2 Udonitrectag
9 In Vivo Evaluation of Corneal Nerves and Epithelial Healing After Treatment With Nerve Growth Factor for Neurotrophic Keratopathy Completed NCT04293549 Cenegermin, recombinant human Nerve Growth Factor (rhNGF) eyedrops
10 Efficacy of Amniotic Membrane Transplantation and Autologous Serum in Treatment of Persistent Epithelial Defects Completed NCT00238862 Autologous serum/BSS 20%
11 Effects of Subtenon-injected Autologous Platelet-rich Plasma on Visual Functions in Eyes With Retinitis Pigmentosa Completed NCT04238858
12 Prevalence of Decreased Corneal Sensation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy Completed NCT01379833
13 Pilot Phase. Cord Blood Serum in the Treatment of Ocular Surface Diseases Completed NCT01234623
14 Miniinvasive Corneal Neurotization. A Pilot Study. Recruiting NCT03037450

Search NIH Clinical Center for Neurotrophic Keratopathy

Genetic Tests for Neurotrophic Keratopathy

Anatomical Context for Neurotrophic Keratopathy

MalaCards organs/tissues related to Neurotrophic Keratopathy:

40
Eye, Brain, Breast, T Cells, Endothelial

Publications for Neurotrophic Keratopathy

Articles related to Neurotrophic Keratopathy:

(show top 50) (show all 310)
# Title Authors PMID Year
1
In Vivo Corneal Confocal Microscopy: Pre- and Post-operative Evaluation in a Case of Corneal Neurotization. 61
32395173 2020
2
Corneal Neurotization: A Surgical Treatment for Neurotrophic Keratopathy. 61
32349065 2020
3
In vivo evaluation of corneal nerves and epithelial healing after treatment with recombinant nerve growth factor for neurotrophic keratopathy. 61
32387431 2020
4
Development of Corneal Sensation With Remodeling of the Epithelium and the Palisades of Vogt After Corneal Neurotization. 61
31990849 2020
5
Finger-Prick Autologous Blood in the Treatment of Persistent Corneal Epithelial Defects. 61
31868852 2020
6
Development of the neurotrophic keratopathy questionnaire: qualitative research. 61
32367451 2020
7
Arthrographis kalrae Keratitis Complicated by Endophthalmitis: A Case Report With Literature Review. 61
32443014 2020
8
Neurotrophic keratitis: Frequency, etiologies, clinical management and outcomes. 61
31759182 2020
9
[A clinical analysis of 46 cases of neurotrophic keratitis]. 61
32306622 2020
10
Cenegermin: A Review in Neurotrophic Keratitis. 61
32185680 2020
11
Effect of epidermal growth factor ointment on persistent epithelial defects of the cornea. 61
32295556 2020
12
Results of a third Gamma Knife radiosurgery for trigeminal neuralgia. 61
32330887 2020
13
Corneal Neurotization for Postherpetic Neurotrophic Keratopathy: Initial Experience and Clinical Outcomes. 61
32332687 2020
14
Eye care providers' emerging roles in early detection of diabetes and management of diabetic changes to the ocular surface: a review. 61
32299899 2020
15
Shp2-mediated MAPK pathway regulates ΔNp63 in epithelium to promote corneal innervation and homeostasis. 61
31653968 2020
16
The supraorbital and supratrochlear nerves for ipsilateral corneal neurotization: anatomical study. 61
32274242 2020
17
A Review of Imaging Biomarkers of the Ocular Surface. 61
31833999 2020
18
[Corneal neurotization]. 61
31667546 2020
19
Epithelial Plaque Formation Secondary to Recombinant Human Nerve Growth Factor. 61
32141943 2020
20
In Vivo and Ex Vivo Comprehensive Evaluation of Corneal Reinnervation in Eyes Neurotized With Contralateral Supratrochlear and Supraorbital Nerves. 61
31335523 2020
21
Clinical and Morphologic Outcomes of Minimally Invasive Direct Corneal Neurotization. 61
32032169 2020
22
Corneal Involvement in Wallenberg Syndrome: Case Report and Literature Review. 61
32076452 2020
23
Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial. 61
31585826 2020
24
Corneal Neurotization: A Review of Pathophysiology and Outcomes. 61
31923091 2020
25
Topical Pergolide Enhance Corneal Nerve Regrowth Following Induced Corneal Abrasion. 61
31999819 2020
26
Corneal hypoesthesia, aqueous tear deficiency, and neurotrophic keratopathy following micropulse transscleral cyclophotocoagulation in dogs. 61
31464376 2020
27
En-Bloc Resection Versus Resection After Evacuation and Suction of the Content for Orbital Optic Nerve Glioma Causing Visual Loss and Disfiguring Proptosis. 61
31917767 2020
28
Intrastromal bevacizumab in the management of corneal neovascularization: a retrospective review. 61
31713747 2020
29
[Orbital Amyloidosis - Comparison of Two Different Clinical Courses]. 61
31968364 2020
30
Herpes zoster keratouveitis with hypopyon and hyphema. 61
32309125 2020
31
Corneal Ulcer Treated with 0.66% Nanoemulsion Povidone-Iodine: A Case Report. 61
31974332 2020
32
Amniotic membrane transplantation for managing dry eye and neurotrophic keratitis. 61
32309119 2020
33
Nerve growth factor in dogs: Assessment of two immunoassays and selected ocular parameters following a nicergoline challenge per os. 61
31774231 2020
34
Fulminant Sphingomonas paucimobilis keratitis: case study and review of literature. 61
31801779 2019
35
Cenegermin for Treating Neurotrophic Keratitis: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. 61
31240690 2019
36
Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation. 61
30770356 2019
37
Herpetic Corneal Keratopathy Management Using Ipsilateral Supratrochlear Nerve Transfer for Corneal Neurotization. 61
31609805 2019
38
Cenegermin in Pediatric Neurotrophic Keratopathy. 61
31403527 2019
39
Corneal nerves in health and disease. 61
31075321 2019
40
Recent innovations with drugs in clinical trials for neurotrophic keratitis and refractory corneal ulcers. 61
31596151 2019
41
Neurotrophic keratopathy: Pros and cons of current treatments. 61
31526824 2019
42
Longitudinal Morphometric Analysis of Sub-Basal Nerve Plexus in Contralateral Eyes of Patients with Unilateral Neurotrophic Keratitis. 61
31125269 2019
43
Neurotrophic keratitis after micropulse transscleral diode laser cyclophotocoagulation. 61
31193794 2019
44
Blood-Based Treatments for Severe Dry Eye Disease: The Need of a Consensus. 61
31533289 2019
45
Corneal neurotisation by great auricular nerve transfer and scleral-corneal tunnel incisions for neurotrophic keratopathy. 61
30470713 2019
46
[Neurotrophic keratopathy : Principles, diagnostics and treatment]. 61
31372724 2019
47
REVERSIBLE NEUROTROPHIC KERATOPATHY ASSOCIATED WITH ROSUVASTATIN THERAPY: A CASE REPORT. 61
31577084 2019
48
Tuck-In Tenon Patch Graft in Corneal Perforation. 61
31276458 2019
49
Lateral Antebrachial Cutaneous Nerve as Autologous Graft for Mini-Invasive Corneal Neurotization (MICORNE). 61
31246678 2019
50
Use of Tachosil® as an adjuvant therapeutic option in neurotrophic keratopathy in order to prevent perforation. 61
31238463 2019

Variations for Neurotrophic Keratopathy

Expression for Neurotrophic Keratopathy

Search GEO for disease gene expression data for Neurotrophic Keratopathy.

Pathways for Neurotrophic Keratopathy

Pathways related to Neurotrophic Keratopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 TACR1 TAC1
2 11.17 TACR1 TAC1
3 9.47 TACR1 TAC1

GO Terms for Neurotrophic Keratopathy

Biological processes related to Neurotrophic Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.32 TACR1 TAC1
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.26 TACR1 TAC1
3 response to pain GO:0048265 9.16 TACR1 TAC1
4 tachykinin receptor signaling pathway GO:0007217 8.96 TACR1 TAC1
5 detection of abiotic stimulus GO:0009582 8.62 TACR1 TAC1

Sources for Neurotrophic Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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