Neutropenia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: NTR004 MIFTS: 63	Neutropenia Categories: Blood diseases, Bone diseases, Cancer diseases, Endocrine diseases, Genetic diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Neutropenia

MalaCards integrated aliases for Neutropenia:

Name: Neutropenia ¹² ²⁹ ⁵⁴ ⁶ ⁴³ ¹⁵ ³⁷ ⁷¹

Leukopenia ⁷¹

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Cancer diseases
Anatomical: Blood diseases Neuronal diseases Bone diseases Immune diseases Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Other diseases of blood and blood-forming organs

Agranulocytosis

External Ids:

Disease Ontology ¹² DOID:1227

ICD9CM ³⁴ 288.0

MeSH ⁴³ D009503

SNOMED-CT ⁶⁷ 303011007

ICD10 ³² D70

UMLS ⁷¹ C0023530 C0027947

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Summaries for Neutropenia

MalaCards based summary : Neutropenia, also known as leukopenia, is related to neutropenia, severe congenital, 3, autosomal recessive and cyclic neutropenia. An important gene associated with Neutropenia is ELANE (Elastase, Neutrophil Expressed), and among its related pathways/superpathways are JAK-STAT signaling pathway and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Aztreonam and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and neutrophil, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : ⁷⁴ Neutropenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood.... more...

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Related Diseases for Neutropenia

Diseases in the Neutropenia family:

Neutropenia, Chronic Familial	Neutropenia, Severe Congenital, 1, Autosomal Dominant
Neutropenia, Severe Congenital, 3, Autosomal Recessive	Neutropenia, Severe Congenital, 4, Autosomal Recessive
Neutropenia, Severe Congenital, 2, Autosomal Dominant	Neutropenia, Severe Congenital, 5, Autosomal Recessive
Neutropenia, Severe Congenital, 6, Autosomal Recessive	Neutropenia, Severe Congenital, 7, Autosomal Recessive
Neutropenia, Severe Congenital, 8, Autosomal Dominant	Severe Congenital Neutropenia
Severe Congenital Neutropenia 1	Elane-Related Neutropenia
Severe Congenital Neutropenia Autosomal Dominant	Acquired Neutropenia
Autosomal Recessive Severe Congenital Neutropenia

Diseases related to Neutropenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 957)

#	Related Disease	Score	Top Affiliating Genes
1	neutropenia, severe congenital, 3, autosomal recessive	35.0	IL3 HAX1 ELANE CSF3R CSF3 CSF2
2	cyclic neutropenia	34.9	USB1 TAZ SLC37A4 JAGN1 IL3 HAX1
3	severe congenital neutropenia	34.9	WAS VPS45 JAGN1 IL3 HAX1 GFI1
4	idiopathic neutropenia	34.6	GFI1 CSF3R
5	severe congenital neutropenia autosomal dominant	34.6	GFI1 ELANE
6	autosomal recessive severe congenital neutropenia	34.5	HAX1 G6PC3 ELANE CSF3R
7	felty syndrome	34.1	IL3 ELANE CSF3 CSF2
8	whim syndrome	33.7	HAX1 G6PC3 ELANE CSF3
9	shwachman-diamond syndrome 1	33.5	HAX1 G6PC3 ELANE CSF3R CSF3
10	cohen syndrome	33.4	VPS45 VPS13B JAGN1 HAX1 G6PC3
11	leukemia, acute lymphoblastic	32.8	TPMT TOP1 IL3 CSF3R CSF3 CSF2
12	granulocytopenia	32.1	IL3 CSF3 CSF2
13	thiopurines, poor metabolism of, 1	32.1	UGT1A1 TPMT
14	bacterial infectious disease	32.0	IL3 ELANE CSF3 CSF2
15	thrombocytopenia	31.7	WAS TOP1 IL3 CSF3 CSF2
16	leukemia, acute myeloid	31.7	TOP1 IL3 GFI1 CSF3R CSF3 CSF2
17	mucositis	31.7	IL3 CSF3 CSF2
18	aspergillosis	31.6	ELANE CSF3 CSF2
19	myelodysplastic syndrome	31.6	TOP1 IL3 HAX1 GFI1 CSF3R CSF3
20	acute leukemia	31.6	TPMT IL3 CSF3R CSF3 CSF2
21	lymphoma, hodgkin, classic	31.4	IL3 CSF3 CSF2
22	diarrhea	31.2	WAS UGT1A1 TOP1 IL3 CSF3
23	large granular lymphocyte leukemia	31.2	CSF3 CSF2
24	aplastic anemia	31.1	TPMT IL3 CSF3R CSF3 CSF2
25	pancytopenia	31.1	TPMT IL3 G6PC3 CSF3 CSF2
26	myelofibrosis	30.9	VPS45 IL3 CSF3R CSF3 CD177
27	mucormycosis	30.9	CSF3 CSF2
28	leukemia, chronic myeloid	30.9	IL3 ELANE CSF3R CSF3 CSF2 CD177
29	gastroenteritis	30.9	IL3 CSF3 CSF2
30	refractory anemia	30.7	IL3 CSF3
31	chronic myelomonocytic leukemia	30.6	TOP1 CSF3R CSF3 CSF2
32	thrombocytosis	30.5	IL3 CSF3 CSF2 CD177
33	acute promyelocytic leukemia	30.5	IL3 ELANE CSF3R CSF3 CSF2
34	polycythemia vera	30.5	IL3 CSF3R CSF3 CSF2 CD177
35	hematologic cancer	30.4	TOP1 IL3 CSF3R CSF3 CSF2
36	retinitis pigmentosa and erythrocytic microcytosis	30.3	IL3 CSF3
37	myeloproliferative neoplasm	30.3	IL3 CSF3R CSF3 CSF2 CD177
38	hemorrhagic cystitis	30.0	TOP1 CSF3
39	poikiloderma with neutropenia	12.8
40	neutropenia, nonimmune chronic idiopathic, of adults	12.6
41	neutropenia, severe congenital, x-linked	12.6
42	neutropenia, severe congenital, 5, autosomal recessive	12.6
43	neutropenia, severe congenital, 1, autosomal dominant	12.6
44	neutropenia, severe congenital, 7, autosomal recessive	12.6
45	neutropenia, severe congenital, 4, autosomal recessive	12.6
46	anemia, x-linked, with or without neutropenia and/or platelet abnormalities	12.6
47	neutropenia, severe congenital, 2, autosomal dominant	12.6
48	neutropenia, severe congenital, 6, autosomal recessive	12.5
49	neutropenia, severe congenital, 8, autosomal dominant	12.5
50	severe congenital neutropenia 1	12.4

Comorbidity relations with Neutropenia via Phenotypic Disease Network (PDN): (show all 45)

Acquired Thrombocytopenia	Active Peptic Ulcer Disease
Acute Cystitis	Acute Kidney Failure
Acute Leukemia	Agammaglobulinemia, X-Linked
Anemia, Autoimmune Hemolytic	Bladder Cancer
Bronchitis	Colorectal Cancer
Decubitus Ulcer	Deficiency Anemia
Esophageal Cancer	Esophageal Candidiasis
Esophagitis	Felty Syndrome
Female Breast Cancer	Gastric Cancer
Heart Disease	Hepatic Encephalopathy
Hydronephrosis	Hypersplenism
Hypothyroidism	Immune Deficiency Disease
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1	Intestinal Obstruction
Iron Deficiency Anemia	Leukemia, Chronic Lymphocytic
Main Bronchus Cancer	Megakaryocytic Leukemia
Oral Candidiasis	Ovarian Cancer
Paralytic Ileus	Plasma Cell Neoplasm
Pneumocystosis	Portal Hypertension
Postinflammatory Pulmonary Fibrosis	Primary Thrombocytopenia
Protein-Energy Malnutrition	Pulmonary Fibrosis and/or Bone Marrow Failure, Telomere-Related, 2
Respiratory Failure	Retinitis Pigmentosa and Erythrocytic Microcytosis
Rheumatoid Arthritis	Sideroblastic Anemia
Systemic Lupus Erythematosus

Graphical network of the top 20 diseases related to Neutropenia:

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Symptoms & Phenotypes for Neutropenia

GenomeRNAi Phenotypes related to Neutropenia according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00240-S-1	9.93	USB1
2	Decreased viability	GR00249-S	9.93	CLPB CSF2 CSF3R G6PC3 HAX1 TPMT
3	Decreased viability	GR00381-A-1	9.93	JAGN1 USB1
4	Decreased viability	GR00386-A-1	9.93	CD177 CLPB CSF3 JAGN1 SLC37A4 TOP1
5	Decreased viability	GR00402-S-2	9.93	G6PC3 IL3 VPS45
6	Increased the percentage of infected cells	GR00402-S-1	8.32	TOP1

MGI Mouse Phenotypes related to Neutropenia:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.73	CD177 CSF2 CSF3 CSF3R ELANE G6PC3
2	immune system	MP:0005387	9.36	CD177 CSF2 CSF3 CSF3R ELANE G6PC3

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Drugs & Therapeutics for Neutropenia

Drugs for Neutropenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 629)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Aztreonam

Approved

Phase 4

78110-38-0

5742832 5362041

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

6741

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

5755

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Lumefantrine

Approved

Phase 4

82186-77-4

6437380

Artemether

Approved

Phase 4

71963-77-4

68911 9796294 119380

Teicoplanin

Approved, Investigational

Phase 4

61036-62-2

Ceftazidime

Approved

Phase 4

72558-82-8, 78439-06-2

5481173

Tobramycin

Approved, Investigational

Phase 4

32986-56-4

36294 5496

Azathioprine

Approved

Phase 4

446-86-6

2265

Penicillin G

Approved, Vet_approved

Phase 4

61-33-6

5904

Sodium citrate

Approved, Investigational

Phase 4

68-04-2

acetic acid

Approved

Phase 4

64-19-7

176

Phenytoin

Approved, Vet_approved

Phase 4

57-41-0

1775

Doripenem

Approved, Investigational

Phase 4

148016-81-3

73303

Heparin

Approved, Investigational

Phase 4

9005-49-6

46507594 772

Promethazine

Approved, Investigational

Phase 4

60-87-7

4927

Metoclopramide

Approved, Investigational

Phase 4

364-62-5

4168

Diphenhydramine

Approved, Investigational

Phase 4

58-73-1, 147-24-0

3100

Dopamine

Approved

Phase 4

51-61-6, 62-31-7

681

Moxifloxacin

Approved, Investigational

Phase 4

354812-41-2, 151096-09-2

152946

Peginterferon alfa-2a

Approved, Investigational

Phase 4

198153-51-4

5360545

Sucralfate

Approved

Phase 4

54182-58-0

Brodalumab

Approved, Investigational

Phase 4

1174395-19-7

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

5754

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

Acetaminophen

Approved

Phase 4

103-90-2

1983

Ceftriaxone

Approved

Phase 4

73384-59-5

5361919 5479530

Cefpirome

Approved

Phase 4

84957-29-9

5479539

Tazobactam

Approved

Phase 4

89786-04-9

123630

Piperacillin

Approved

Phase 4

66258-76-2

43672

Meropenem

Approved, Investigational

Phase 4

96036-03-2, 119478-56-7

441130 64778

Nicotine

Approved

Phase 4

54-11-5

942 89594

Radium Ra 223 dichloride

Approved, Investigational

Phase 4

444811-40-9

Abatacept

Approved

Phase 4

332348-12-6

10237

Hydroxyurea

Approved

Phase 4

127-07-1

3657

Levofloxacin

Approved, Investigational

Phase 4

100986-85-4

149096

Ofloxacin

Approved

Phase 4

82419-36-1

4583

Daratumumab

Approved

Phase 4

945721-28-8

Sotalol

Approved

Phase 4

3930-20-9, 959-24-0

5253

Clotrimazole

Approved, Vet_approved

Phase 4

23593-75-1

2812

Miconazole

Approved, Investigational, Vet_approved

Phase 4

22916-47-8

4189

Sirolimus

Approved, Investigational

Phase 4

53123-88-9

5284616 6436030 46835353

Caspofungin

Approved

Phase 4

162808-62-0, 179463-17-3

2826718 468682

Itraconazole

Approved, Investigational

Phase 4

84625-61-6

55283

Amphotericin B

Approved, Investigational

Phase 4

1397-89-3

5280965 14956

Mycophenolic acid

Approved

Phase 4

24280-93-1

446541

Citric acid

Approved, Nutraceutical, Vet_approved

Phase 4

77-92-9

311

Interventional clinical trials:

(show top 50) (show all 1114)

#	Name	Status	NCT ID	Phase	Drugs
1	Optimal Timing and Duration of Daily G-CSF With Adjuvant TAC Chemotherapy in Node-positive Breast Cancer;Multicenter, Randomized, Open Label, Clinically IV Phase	Unknown status	NCT01571518	Phase 4	late leukostim;early leukostim
2	The Efficacy and Safety of PEG-rhG-CSF in Neutropenia After Chemotherapy	Unknown status	NCT02905916	Phase 4	PEG-rhG-CSF
3	Efficacy and Safety in Micafungin Sodium for Prophylaxis Against Invasive Fungal Disease During Neutropenia in Pediatric & Adolescent Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation	Unknown status	NCT01135589	Phase 4	Micafungin
4	A Prospective, Open, Randomized, Controlled Clinical Study to Evaluate the Efficacy and Safety of PEG-rhG-CSF in Reducing Neutropenia in Patients With Cervical Cancer	Unknown status	NCT03206684	Phase 4	PEG-rhG-CSF;rhG-CSF
5	PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia	Unknown status	NCT02996617	Phase 4	rhG-CSF regimen;Pegylated rhG-CSF regimen
6	G-CSF (Filgrastim) or Pegfilgrastim Secondary Prophylaxis In The Adjuvant Chemotherapy Of Early Breast Cancer	Unknown status	NCT00030758	Phase 4
7	Prospective Unblinded Randomized Trial to Examine Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia	Unknown status	NCT02463747	Phase 4	Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
8	Validation of Central Venous (Port A Cath®) Blood Draws for Ciprofloxacin Pharmacokinetic Research in Patients Under Treatment for Childhood Cancer	Unknown status	NCT02967341	Phase 4
9	An Open-Lable Multicenter Prospective Non-Randomized Trial to Assess the Efficacy and Safety of Morinidazole With Surgery in Patients With Suppurative or Gangrenous Appendicitis	Unknown status	NCT03380793	Phase 4	morinidazole
10	Evaluation of Effectiveness and Safety of Oral Vancomycin in Treatment of Primary Sclerosing Cholangitis.	Unknown status	NCT02605213	Phase 4	Vancomycin;Placebo
11	An Open-Lable Multicenter Prospective Non-Randomized Trial to Assess the Efficacy and Safety of Morinidazole With Levofloxacin and Sequential of Levofloxacin in Women With Pelvic Inflammatory Disease	Unknown status	NCT03391440	Phase 4	morinidazole
12	The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome	Unknown status	NCT00127985	Phase 4	6-methyl-prednisolone
13	Efficacy and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for the Treatment of Uncomplicated Malaria in Guinea-Bissau.	Unknown status	NCT01704508	Phase 4	Artemether-lumefantrine;Dihydroartemisinin-piperaquine
14	Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients	Completed	NCT00454272	Phase 4	Teicoplanin;Vancomycin
15	Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia Following Administration by 4-hour Infusion and Bolus Injection.	Completed	NCT02213783	Phase 4	Imipenem;Imipenem
16	A Multicenter, Open-label, Phase 4 Study of Pegfilgrastim Administered in the First and Subsequent Cycles of Myelosuppressive Chemotherapy	Completed	NCT00125723	Phase 4
17	A Randomized, Open Label, Multicenter Study of Primary Prophylaxis With Neulasta (Pegfilgrastim) Versus Secondary Prophylaxis as an Adjunct to Chemotherapy in Elderly Subjects (>/= 65 Years Old) With Cancer	Completed	NCT00277160	Phase 4	Neulasta (pegfilgrastim)
18	A Multi-center, Open-label,Single Arm Phase IV Clinical Trial of Efficacy and Safety of PEG-rhG-CSF in Preventing Neutropenia in Patients With Breast Cancer Receiving Chemotherapy	Completed	NCT02805205	Phase 4	PEG-rhG-CSF
19	Randomized Open Label Clinical Trial Directed to Optimize the Duration of Empirical Antimicrobial Therapy in Haematologic Patients With Febrile Neutropenia	Completed	NCT01581333	Phase 4	Empirical antimicrobial treatment discontinuation;Standard empirical antimicrobial treatment discontinuation
20	A Pilot Study of the Effects of Neutropenia on Patient Reported Outcomes During Chemotherapy With or Without Neulasta® (Pegfilgrastim) in Subjects With Advanced NSCLC	Completed	NCT00115206	Phase 4	Neulasta® (pegfilgrastim)
21	Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With Fever of Unknown Origin: a Randomized Multicenter Non-inferiority Trial.	Completed	NCT02149329	Phase 4	Discontinuation of imipenem-cilastatin or meropenem
22	A Multi Centre Study to Compare Administration Schedules of G-CSF (Filgrastim) for Primary Prophylaxis of Chemotherapy-Induced Febrile Neutropenia in Early Stage Breast Cancer (REaCT-G2)	Completed	NCT02816164	Phase 4	Neupogen
23	A Phase IV Clinical Trial of Patients With Solid Tumours Receiving Granocyte 34 (Granulocyte Colony Stimulating Factor (G-CSF)) as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Taxotere (Docetaxel) Based Regimen	Completed	NCT01107756	Phase 4	LENOGRASTIM (GRANOGYTE 34)
24	A Phase IV, Multicenter, National, Non-comparative, Open-label Study of Cabazitaxel, Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Second-line Treatment of Patients With Metastatic Castration-resistant Prostate Cancer and After Failure of Docetaxel-based Chemotherapy. Descriptive Assessment of the Circulating Tumor Cells in This Context.	Completed	NCT01649635	Phase 4	CABAZITAXEL (XRP6258);Prednisone;Ciprofloxacin;G-CSF (Granulocyte colony-stimulating factor)
25	A Multi-Centre Study to Compare Granulocyte-colony Stimulating Factors to Antibiotics for Primary Prophylaxis of Taxotere/Cyclophosphamide-Induced Febrile Neutropenia REaCT-TC2	Completed	NCT02816112	Phase 4	Ciprofloxacin;Neupogen
26	Tobramycin én Gang Daglig Mot Tre Ganger Daglig, Gitt Med Benzylpenicillin, Til Pasienter Med nøytropen Feber	Completed	NCT00257790	Phase 4	Tobramycin once a day
27	Feasibility of Using an Integrated Consent Model to Compare Two Standard of Care Regimens for Primary Prophylaxis of Taxotere/Cyclophosphamide-Induces Febrile Neutropenia	Completed	NCT02173262	Phase 4	G-CSF;Ciprofloxacin
28	Citrate- Versus Acetate-Based Dialysate in Bicarbonate Haemodialysis: Consequences on Haemodynamics, Coagulation, Acid-Base Status and Electrolytes	Completed	NCT00718289	Phase 4
29	Phenytoin as an Augmentation for SSRI Failures: A Controlled Study	Completed	NCT00146237	Phase 4	phenytoin
30	Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients With Possible Bacterial Infection	Completed	NCT01401010	Phase 4	Doripenem;doripenem
31	ANTIVORIFUNGOL:Strategy of Antifungal Use in Oncohematological Neutropenic Patients. Use of Voriconazole as Early Treatment.	Completed	NCT00386802	Phase 4	Antifungal drug. VORICONAZOL. (VFEND®)
32	Pharmacokinetics of Mycophenolate Mofetil Alone and in Combination With Valganciclovir in Renal and Heart Transplant Recipients	Completed	NCT00189150	Phase 4	Mycophenolate mofetil;Valganciclovir
33	The Multi-center, Open-label,Randomized Comparison Phase IV Clinical Trial of Efficacy and Safety of PEG-rhG-CSF in Preventing Neutropenia in Patients With Breast Cancer Receiving Chemotherapy	Completed	NCT02805153	Phase 4	PEG-rhG-CSF;rhG-CSF
34	Cefepime vs Ceftazidime as Empirical Therapy for Neutropenic Fever in Pediatric Acute Leukemia: Review of Temperature and Absolute Neutrophil	Completed	NCT04187755	Phase 4	Ceftazidime Injection;Cefepime Injection
35	Health Economic Evaluation of Rapid Detection of Bacteraemia and Fungemia by Real Time PCR for Cases of Febrile Neutropenia, Suspicion of Endocarditis and Severe Sepsis in Intensive Care Units	Completed	NCT00709358	Phase 4
36	Safety of Cotrimoxazole in HIV- and HAART-exposed Infants in Botswana	Completed	NCT01086878	Phase 4	cotrimoxazole
37	A Randomized Open-Label Trial of Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome	Completed	NCT01200355	Phase 4	micafungin;posaconazole
38	Evaluate the Safety of Combination of Orectalip® (Oxaliplatin), Fluorouracil and Leucovorin as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer	Completed	NCT02284529	Phase 4	Orectalip
39	Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients	Completed	NCT01114165	Phase 4
40	Effect of Granulocyte-macrophage Stimulating Factor on Prevention and Treatment of Invasive Fungal Diseases in the Recipients of Allogeneic Stem Cell Transplantation: A Prospective Multicenter Randomized Phase 4 Trial	Completed	NCT01232504	Phase 4	rhGM-CSF group;rhG-CSF+rhGM-CSF group;rhG-CSF group
41	A Phase 4 Study of the Pharmacokinetics of Oral Posaconazole (SCH 56592) Among Patients With Compromised Gastrointestinal Function and at High Risk for Invasive Fungal Infection	Completed	NCT00686543	Phase 4	Posaconazole
42	PETHEMA-LAM99:Treatment of the Acute Myeloblastic Leukaemia in Patients Over 65 Years	Completed	NCT00464217	Phase 4	ARA-C;Idarubicin;Leucomax
43	Comparison the Safety and Efficacy of Epirubicin Plus Cyclophosphamide (EC)Versus Docetaxel Plus Cyclophosphamide (TC) in Lymph Node Negative, ER Positive, Her2 Negative Breast Cancer Patients as Adjuvant Chemotherapy	Completed	NCT02549677	Phase 4	Epirubicin;Docetaxel;cyclophosphamide
44	Expanded Access Program of Pegfilgrastim in Patients With Non-Hodgkin Lymphoma (NHL)	Completed	NCT02782845	Phase 4	Chemotherapy;Immunochemotherapy;Pegfilgrastim
45	Comparison of a Tacrolimus/Sirolimus/Prednisone Regimen Versus Tacrolimus/Azathioprine/Prednisone Immunosuppressive Regimen in Lung Transplantation	Completed	NCT00321906	Phase 4	azathioprine;sirolimus
46	Cabazitaxel in Combination With Prednisolone With Primary Prophylaxis With PEG-G-CSF for the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer	Completed	NCT02441894	Phase 4	CABAZITAXEL XRP6258;PEG-G-CSF;Prednisolone;Dexchlorpheniramine or Diphenhydramine;Ranitidine;Metoclopramide, Granisetron, or Ondansetron;Dexamethasone
47	Association Between Response to Aggressive Chemotherapy and Doxorubicin Pharmacokinetics in Non Hodgkin's Lymphoma Patients	Completed	NCT00969462	Phase 4	Doxorubicin
48	Multicenter Exploratory Trial of the Safety and Efficacy of Adjuvant Docetaxel and Carboplatin in Patients With Resected Non-small Cell Lung Cancer	Completed	NCT00883675	Phase 4	Docetaxel-Carboplatin
49	A Phase IV Study to Evaluate Decreased Dose Frequency in Patients With Systemic Juvenile Arthritis (SJIA) Who Experience Laboratory Abnormalities During Treatment With Tocilizumab	Completed	NCT01734382	Phase 4	Tocilizumab
50	Steady-State Comparative Bioavailability Study in Patients Requiring Anti-Fungal Prophylaxis Comparing Twice a Day Dosing of Lozanoc® (Mayne) Regardless of Food With Sporanox® (Janssen) Under Fed Conditions	Completed	NCT02621905	Phase 4	Sporanox;Lozanoc

Search NIH Clinical Center for Neutropenia

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Ciprofloxacin

Filgrastim

FILGRASTIM-SNDZ

Immunoglobulins, Intravenous

Itraconazole

pegfilgrastim

sargramostim

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Neutropenia cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Neutropenia:

Hematopoietic stem cell transplantation for the treatment of genetic blood cell-related diseases

Embryonic/Adult Cultured Cells Related to Neutropenia:

	Umbilical cord blood-derived hematopoietic stem cells (family)
	Bone marrow-derived hematopoietic stem cells (family)

Cochrane evidence based reviews: neutropenia

Sources

Genetic Tests for Neutropenia

Genetic tests related to Neutropenia:

#	Genetic test	Affiliating Genes
1	Neutropenia ²⁹

Sources

Anatomical Context for Neutropenia

MalaCards organs/tissues related to Neutropenia:

⁴⁰

Lung, Breast, Neutrophil, Bone, Myeloid, Bone Marrow, Prostate

Sources

Publications for Neutropenia

Articles related to Neutropenia:

(show top 50) (show all 39854)

#	Title	Authors	PMID	Year
1	Review article: optimizing SVR and management of the haematological side effects of peginterferon/ribavirin antiviral therapy for HCV - the role of epoetin, G-CSF and novel agents. ⁶¹ ⁵⁴	Mac Nicholas R...Norris S	20175767	2010
2	Granulocyte colony-stimulating factor in toxic epidermal necrolysis (TEN) and Chelsea & Westminster TEN management protocol [corrected]. ⁶¹ ⁵⁴	de Sica-Chapman A...Bunker CB	19912214	2010
3	Thiopurine S- methyltransferase [corrected] testing in idiopathic pulmonary fibrosis: a pharmacogenetic cost-effectiveness analysis. ⁵⁴ ⁶¹	Hagaman JT...Eckman MH	20066544	2010
4	Circadian rhythm of neutrophil counts and granulocyte macrophage-colony stimulating factor (GM-CSF) under clozapine treatment: a case report. ⁵⁴ ⁶¹	Ferrea S...Luckhaus C	19396726	2010
5	Phase II study of paclitaxel and irinotecan with intercalated gefitinib in patients with advanced non-small-cell lung cancer. ⁶¹ ⁵⁴	Oshita F...Yamada K	19786849	2010
6	Genetic insights into congenital neutropenia. ⁶¹ ⁵⁴	Klein C...Welte K	19440858	2010
7	Are patients with intermediate TPMT activity at increased risk of myelosuppression when taking thiopurine medications? ⁵⁴ ⁶¹	Higgs JE...Newman WG	20136357	2010
8	Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. ⁵⁴ ⁶¹	Jones G...Genovese MC	19297346	2010
9	A CYP3A4 phenotype-based dosing algorithm for individualized treatment of irinotecan. ⁵⁴ ⁶¹	van der Bol JM...de Jong FA	20068078	2010
10	Which role for rituximab in hairy cell leukemia? Reflections on six cases. ⁵⁴ ⁶¹	Malfuson JV...de Revel T	20051682	2010
11	Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status. ⁵⁴ ⁶¹	Stocco G...Evans WE	20021291	2010
12	Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more. ⁵⁴ ⁶¹	Liongue C...Ward AC	19699815	2009
13	Prolonged neutropenia after irinotecan-based chemotherapy in a child with polymorphisms of UGT1A1 and SLCO1B1. ⁶¹ ⁵⁴	Sakaguchi S...Ito S	19608554	2009
14	Phase II randomized study of trabectedin given as two different every 3 weeks dose schedules (1.5 mg/m2 24 h or 1.3 mg/m2 3 h) to patients with relapsed, platinum-sensitive, advanced ovarian cancer. ⁶¹ ⁵⁴	Del Campo JM...Yondelis Ovarian Cancer Group	19556318	2009
15	G-CSF in Peg-IFN induced neutropenia in liver transplanted patients with HCV recurrence. ⁶¹ ⁵⁴	Lodato F...Mazzella G	19916175	2009
16	An outbreak of Crimean-Congo hemorrhagic fever in western Anatolia, Turkey. ⁶¹ ⁵⁴	Ertugrul B...Sakarya S	19409826	2009
17	Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients. ⁶¹ ⁵⁴	Low SK...Zembutsu H	19696793	2009
18	G-CSF receptor (CSF3R) mutations in X-linked neutropenia evolving to acute myeloid leukemia or myelodysplasia. ⁵⁴ ⁶¹	Beel K...Vandenberghe P	19794089	2009
19	Prospective study of Chikungunya virus acute infection in the Island of La Réunion during the 2005-2006 outbreak. ⁶¹ ⁵⁴	Staikowsky F...Michault A	19893613	2009
20	A phase 2 trial of surgery with perioperative INGN 201 (Ad5CMV-p53) gene therapy followed by chemoradiotherapy for advanced, resectable squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx: report of the Southwest Oncology Group. ⁶¹ ⁵⁴	Yoo GH...Wolf G	19770418	2009
21	SBDS expression and localization at the mitotic spindle in human myeloid progenitors. ⁶¹ ⁵⁴	Orelio C...Kuijpers TW	19759903	2009
22	Prevention of febrile neutropenia: use of granulocyte colony-stimulating factors. ⁵⁴ ⁶¹	Kelly S...Wheatley D	19756005	2009
23	Combined weekly carboplatin and paclitaxel as primary treatment of advanced epithelial ovarian carcinoma. ⁵⁴ ⁶¹	Safra T...Levy T	19446318	2009
24	Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain. ⁶¹ ⁵⁴	Gurwitz D...Ibarreta D	19223932	2009
25	A history of smoking is inversely correlated with the incidence of gemcitabine-induced neutropenia. ⁶¹ ⁵⁴	Kanai M...Fukushima M	19457938	2009
26	Comprehensive analysis of excision repair complementation group 1, glutathione S-transferase, thymidylate synthase and uridine diphosphate glucuronosyl transferase 1A1 polymorphisms predictive for treatment outcome in patients with advanced gastric cancer treated with FOLFOX or FOLFIRI. ⁶¹ ⁵⁴	Seo BG...Kim HJ	19513514	2009
27	[Two cases of advanced colorectal cancer with UGT1A1*28 homozygosity treated by FOLFIRI]. ⁵⁴ ⁶¹	Yokoyama S...Morita Y	19620808	2009
28	Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease. ⁵⁴ ⁶¹	Takatsu N...Yao K	19682195	2009
29	[Allelic variants of TPMT and the risk of leucopenia and neutropenia in patients treated for acute leukaemia]. ⁶¹ ⁵⁴	Niedzielska E...Chybicka A	20081263	2009
30	Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan. ⁶¹ ⁵⁴	Hoskins JM...Innocenti F	19604089	2009
31	Association of genetic polymorphisms with interferon-induced haematologic adverse effects in chronic hepatitis C patients. ⁵⁴ ⁶¹	Wada M...Matsuda F	19200137	2009
32	Clinical features of human influenza A (H5N1) infection in Vietnam: 2004-2006. ⁵⁴ ⁶¹	Liem NT...Horby P	19435433	2009
33	Complement factors C3a and C5a have distinct hemodynamic effects in the rat. ⁵⁴ ⁶¹	Proctor LM...Woodruff TM	19285573	2009
34	Marked downregulation of the granulopoiesis regulator LEF1 is associated with disease progression in the myelodysplastic syndromes. ⁶¹ ⁵⁴	Pellagatti A...Boultwood J	19438482	2009
35	Treatment outcomes of sunitinib treatment in advanced renal cell carcinoma patients: a single cancer center experience in Korea. ⁶¹ ⁵⁴	Hong MH...Rha SY	19707503	2009
36	XM02, the first biosimilar G-CSF, is safe and effective in reducing the duration of severe neutropenia and incidence of febrile neutropenia in patients with small cell or non-small cell lung cancer receiving platinum-based chemotherapy. ⁶¹ ⁵⁴	Gatzemeier U...Del Giglio A	19404210	2009
37	UGT1A1*28 genotype predicts gastrointestinal toxicity in patients treated with intermediate-dose irinotecan. ⁶¹ ⁵⁴	Ferraldeschi R...Newman WG	19450125	2009
38	Ela2 mutations and clinical manifestations in familial congenital neutropenia. ⁵⁴ ⁶¹	Shiohara M...Koike K	19415009	2009
39	A novel mutation in the G4.5 (TAZ) gene in a Greek patient with Barth syndrome. ⁵⁴ ⁶¹	Bachou T...Kattamis A	19261493	2009
40	Neutropenia in congenital nephrotic syndrome of the Finnish type: role of urinary ceruloplasmin loss. ⁵⁴ ⁶¹	Ulinski T...Donadieu J	19423745	2009
41	UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients. ⁵⁴ ⁶¹	Onoue M...Inui K	19390945	2009
42	Neutropenia in a patient treated with ipilimumab (anti-CTLA-4 antibody). ⁶¹ ⁵⁴	Akhtari M...Arellano ML	19242368	2009
43	Cardiolipin and monolysocardiolipin analysis in fibroblasts, lymphocytes, and tissues using high-performance liquid chromatography-mass spectrometry as a diagnostic test for Barth syndrome. ⁵⁴ ⁶¹	Houtkooper RH...Vaz FM	19454236	2009
44	Is there a role for all-trans retinoic acid in combination with recombinant erythropoetin in myelodysplastic syndromes? A report on 59 cases. ⁶¹ ⁵⁴	Itzykson R...Groupe Francophone des Myelodysplasies (GFM)	19151787	2009
45	XM02, the first granulocyte colony-stimulating factor biosimilar, is safe and effective in reducing the duration of severe neutropenia and incidence of febrile neutropenia in patients with non-Hodgkin lymphoma receiving chemotherapy. ⁶¹ ⁵⁴	Engert A...del Giglio A	19347726	2009
46	[Autoimmune thrombocytopenia, neutropenia and hemolysis]. ⁵⁴ ⁶¹	Greinacher A...Salama A	19225748	2009
47	Shwachman-Diamond syndrome neutrophils have altered chemoattractant-induced F-actin polymerization and polarization characteristics. ⁶¹ ⁵⁴	Orelio C...Kuijpers TW	19211642	2009
48	Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia. ⁵⁴ ⁶¹	Stocco G...Evans WE	18685564	2009
49	Management of chemotherapy-induced thrombocytopenia: current status of thrombopoietic agents. ⁵⁴ ⁶¹	Vadhan-Raj S	19245931	2009
50	Prophylactic antibiotics or G-CSF for the prevention of infections and improvement of survival in cancer patients undergoing chemotherapy. ⁶¹ ⁵⁴	Herbst C...Engert A	19160320	2009

Sources

Genes for Neutropenia

Genes related to Neutropenia (2 elite genes):

(show top 50) (show all 75)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	ELANE	Elastase, Neutrophil Expressed	Protein Coding	452.48	Pathogenic/Likely pathogenic ⁶ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)	18334177 14962902 17053055 (more) 15059607 16986121 12778173 14673143 11722436 15561677 17917547 19440858 20008220 12763135 14732495 12745650 18632498 18028488 17133096 12897784 11286224 16551967 17931556 17537008 17202606 12393522 11001877 19415009 18536571 18528462 15657182 15973448
2	VPS13B	Vacuolar Protein Sorting 13 Homolog B	Protein Coding	420.87	Pathogenic/Likely pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
3	CSF3	Colony Stimulating Factor 3	Protein Coding	66.58	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Summaries Proteins Functions (show sections)	9885374 9072843 17726809 (more) 19486571 8614070 11410799 7691114 7506558 11244158 15205265 1689286 16080844 16187231 1372661 7511543 11432350 12168878 8641928 7684099 1380256 7543781 16098118 11429005 7502498 7516641 7531660 1713806 2405493 1284910 7505809 7510482 8065017 7693069 11475155 11229845 11032370 9167761 9020947 8616084 7826082 7528962 7518817 12399133 11710776 11551421 9427781 8794414 8749950 8721901 7510488 7691117 16410696 10442369 10553163 7536371 7509576 7681699 1721656 7923328 16227739 10708106 10518200 10326746 10613592 9830435 9831213 9703823 9704721 9394563 10781685 8895681 8544376 1282108 1279140 1377928 1704624 18187952 18190472 15520071 12557705 11915741 11680980 10857893 9422066 9266259 8742097 7595759 7688831 1373051 1777217 16755112 16756147 15251366 14650969 1281810 1379115 18166289 17460557 16498230 17402806 12636092 1711156 10887102 9170417 15806544 8652892 9369920 10897813 11136839 1373969 18927273 11957196 14737055 17927614 1693298 19322972 7510192 19916175 8644050 1381626 15146222 12489493 15266474 7690396 8622074 12545010 11256242 1374149 8911114 7688362 10423924 11583191 10393604 9474924 9226158 8996068 1384774 19756005 14974009 14750898 9502559 9060560 8589368 7531394 7527850 1702678 11737689 10437984 10423052 10354121 9209840 9187067 19347726 7509462 1700601 16273232 12519588 7542114 7510142 18843642 12425755 10219333 9651406 7540696 16777623 11535993 9797080 8935749 8620626 7688828 19404210 18412800 16110133 15083768 7540401 7515635 12508486 9187068 1709246 7544025 7522057 7680827 19912214 18493867 18067473 12355486 11904781 10878148 10634646 10461059 9850033 17970641 15496275 15550581 15197801
4	CSF3R	Colony Stimulating Factor 3 Receptor	Protein Coding	63.14	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries Proteins Variants (show sections)	18536571 19794089 11238134 (more) 12670333 17133096 9864153 12489499 15973448 11854931 10634179 9517498 9001427 8913314 19699815 17066093 15370243 9639496 11091218 11807637 14528102 15677477 9421617
5	GFI1	Growth Factor Independent 1 Transcriptional Repressor	Protein Coding	52.25	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)	18328744 17636019 18334177 (more) 20008220 12721361 15618011 17096407 12483111 16716599
6	USB1	U6 SnRNA Biogenesis Phosphodiesterase 1	Protein Coding	52.16	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Variants (show sections)
7	JAGN1	Jagunal Homolog 1	Protein Coding	51.46	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Proteins Variants (show sections)
8	G6PC3	Glucose-6-Phosphatase Catalytic Subunit 3	Protein Coding	44.77	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
9	HAX1	HCLS1 Associated Protein X-1	Protein Coding	44.51	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
10	CLPB	Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit B	Protein Coding	41.16	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
11	SLC37A4	Solute Carrier Family 37 Member 4	Protein Coding	39.32	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Variants (show sections)	16435186 9822626 17478431 (more) 11032333
12	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	37.68	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Variants (show sections)	12483111 16630926 19147084 (more) 17724125 19082760
13	VPS45	Vacuolar Protein Sorting 45 Homolog	Protein Coding	32.72	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
14	CSF2	Colony Stimulating Factor 2	Protein Coding	32.46	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	7725160 7482859 7488824 (more) 1288290 1379115 2177614 1713806 11710776 1777217 12664010 1380256 11932893 1423182 16034921 8458047 9829843 14682115 1492010 14959849 18628156 1515094 2261008 17074671 2182461 1950374 8219192 8058003 7773216 10526278 9531581 9209836 9099971 9013366 8811304 8652846 8636779 8775801 18843642 17155894 12749746 10989467 9053491 7685523 8387346 1728985 2016623 7506061 1457582 1932223 16498390 16173810 15381684 12877668 10786652 9738560 8171389 8347733 1283520 1719175 2008785 15920280 15266474 11944613 11893881 7516925 8450676 1553964 1756194 1742482 1948129 2031965 8625134 16912178 9106171 7916041 17631179 15943026 12174492 11707827 11326688 10764438 8824661 7528449 11100668 10607719 10423582 9209839 8614371 8539860 7549900 8204446 9624538 10170460 8793147 8553081 7526820 7510142 11134431 19859814 2189305 1638464 12804646 12636092 12494898 11957195 10641956 10561379 7740436 7506824 8429694 1975922 19396726
15	TAZ	Tafazzin	Protein Coding	31.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	19057200 9382096 14764526 (more) 12483111 7616547 15098233 20008220 12930833 14662265 9792874 19454236 16794186 17394203 18070816 19261493
16	IL3	Interleukin 3	Protein Coding	30.92	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10553163 10367176 9009076 (more) 2237132 9130684 11148572 9877237 1693298 1384774 10634646 12917942 10613382 8219192 8603021 7787781 11676908 1503352 9372045 16152782 19160320 1609191 7535147 11927737 10221368 10021799 9608494 8803624 8701065 9815905 8528096 7613488 8608239 7948312 8140672 1517788 19108744 18613811 16857151 14657603 14635589 7686502 1515636 1822140 7954241 19322972 17368037 17505218 17116941 15753051 15920280 15915058 14959849 12186123 11893881 11727663 11257589 10079103 9950201 7692952 19323086 16720201 15943026 15081101 12468153 12029429 11528556 10637246 8067201 10518202 9773234 8959393 8914806 7535842 7528449 19242368 17453257 9664165 9374099 9150116 8730024 8907631 8541548 7520782 7506061 14652525 11669301 11053791 10800487 10550156 10189687 9079252 8874763 12749746 11149085 8913281 8639401 8560070 7915156 19245931 16034921 7688362 8445677 1950374 15597023 12415620 9457817
17	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	28.87	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	12485959 19125128 19125129 (more) 19390945 19620808 19608554 19450125 17192505 15007088 17090741
18	TOP1	DNA Topoisomerase I	Protein Coding	28.61	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	15470958 8611374 11081458 (more) 19604089 18347181
19	TPMT	Thiopurine S-Methyltransferase	Protein Coding	28.34	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	18685564 18601797 20081263 (more) 18662289 11876691 16207256 15776134 16898847 7501607 20021291 16431304 19390192 12192200 16044099 10628931 20066544 20027160 7857117 20136357 16166171 17697207 15167634 8687298 12492734 11079044 16175140 17978158 15352906 19682195 19223932
20	CD177	CD177 Molecule	Protein Coding	28.18	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Proteins (show sections)	11927737 11380420 19730745
21	DPYD	Dihydropyrimidine Dehydrogenase	Protein Coding	27.12	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	18299612 12209976 18600532 (more) 11156223 12542909 17097873 15093568 17165084
22	FCGR3B	Fc Fragment Of IgG Receptor IIIb	Protein Coding	26.68	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Functions (show sections)	9028335 9562743 9359005
23	IFNA1	Interferon Alpha 1	Protein Coding	26.68	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	2048563 1634925 2279544 (more) 8339255 10710206 16108170 18756437 1381218 14555307 19200137 9816134 15081101 18086586 12905138 1708757 7666089 16166798 18203019 20051682 8174205 8221559 10213464 12399758 15855796 2361570 9508190 15850469 17100715 7751874 9097287 11426554 2141493 9829841 11244158 16838657
24	FCGR3A	Fc Fragment Of IgG Receptor IIIa	Protein Coding	24.35	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Summaries (show sections)	1385783 2243362
25	IFNA2	Interferon Alpha 2	Protein Coding	22.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15854180 7947290 17489160 (more) 1281810 15670173
26	SBDS	SBDS Ribosome Maturation Factor	Protein Coding	21.78	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders (show sections)	19211642 19759903
27	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	21.67	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
28	IL11	Interleukin 11	Protein Coding	20.83	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19100899 15387143 9371993 (more) 15686455 10421271 8401258 12508148
29	SRP54	Signal Recognition Particle 54	Protein Coding	20.75	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
30	THPO	Thrombopoietin	Protein Coding	20.66	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10437984 8896401 9293906 (more) 10914501 11999567 10227790
31	TYMS	Thymidylate Synthetase	Protein Coding	20.41	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	18299612 16818689 19513514
32	FASLG	Fas Ligand	Protein Coding	20.4	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
33	EPO	Erythropoietin	Protein Coding	20.29	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10561191 2018046 9804442 (more) 15597023 17571966 18290566 16527653 19151787 20175767 8775801 8639764 9099971 10233377 15668278 16595992 1720567 8674788 8338993 17905682 16861940 15032269 10226741 19446318 18019635 17100024 12149237 9625350 1372465 11326688 16984501 15548967 11893881 15886476 17305065 18713253 19795582 2396173 1709368 1382542
34	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	19.46	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19696793 17992531 20068078
35	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	19.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Functions (show sections)
36	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	19.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	17575227 15797363 19297346 (more) 15453926 18097170 19238628 17414138 15328182 19435433 19932054 19457938 15637692 11368105 9838910 9739439 19556318 19707503 17541589 18317763 19770418 18927308 16914578 19786849 17553201 10809816 11014137 17529862 12965923 19409826 8465712 18021976 17653311 11986465
37	KITLG	KIT Ligand	Protein Coding	18.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10914501 16391909 10437984 (more) 10421271
38	GINS1	GINS Complex Subunit 1	Protein Coding	18.5	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
39	CSF1	Colony Stimulating Factor 1	Protein Coding	18.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9256140 11714451 11500084 (more) 10474149 15967829 8196902 18328744 11870809 1587305 17177272 9750020 9577644 12967481 9631577 11979751 9645462 7506061
40	G6PC	Glucose-6-Phosphatase Catalytic Subunit	Protein Coding	18.08	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8641644 9822626 12925567
41	MPO	Myeloperoxidase	Protein Coding	17.63	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9117128 10867537 19082461 (more) 10648394 9249774 9396345 10102950 10792393 8383955 11309818
42	ITGAM	Integrin Subunit Alpha M	Protein Coding	17.6	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8079969 10867537 10075864 (more) 10514074
43	TCIRG1	T Cell Immune Regulator 1, ATPase H+ Transporting V0 Subunit A3	Protein Coding	17.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
44	C5AR1	Complement C5a Receptor 1	Protein Coding	15.58	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19285573 10188960 1751793 (more) 10927032 16893082
45	MBL2	Mannose Binding Lectin 2	Protein Coding	15.53	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	16517152 10476751 17729243 (more) 14616788 16494622 16990992 11530147 14614673 17143875
46	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	15.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8547127 9325020
47	TFRC	Transferrin Receptor	Protein Coding	14.77	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders (show sections)	9414637
48	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	14.71	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19696793
49	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	14.66	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19438482 17063141 17088895 (more) 17133096
50	MPL	MPL Proto-Oncogene, Thrombopoietin Receptor	Protein Coding	14.55	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9372076 19225748

Sources

Variations for Neutropenia

ClinVar genetic disease variations for Neutropenia:

⁶ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	subset of 47 genes: CRKL , TBX1	GRCh37/hg19 22q11.21(chr22:18894835-21505417)	copy number loss	Pathogenic	523274		22:18894835-21505417
2	VPS13B	NM_017890.4(VPS13B):c.4620del (p.Ser1541fs)	deletion	Pathogenic	374163	rs1057518939	8:100523652-100523652	8:99511424-99511424
3	ELANE	NM_001972.4(ELANE):c.597+5G>A	SNV	Pathogenic/Likely pathogenic	245598	rs879253882	19:855799-855799	19:855799-855799
4	VPS13B	NM_017890.4(VPS13B):c.11314C>T (p.Gln3772Ter)	SNV	Pathogenic/Likely pathogenic	56635	rs386834061	8:100880540-100880540	8:99868312-99868312
5	HAX1	NM_006118.4(HAX1):c.182T>G (p.Phe61Cys)	SNV	Likely pathogenic	812887		1:154245940-154245940	1:154273464-154273464
6	SLC37A4	NM_001164277.1(SLC37A4):c.81T>A (p.Asn27Lys)	SNV	Conflicting interpretations of pathogenicity	68290	rs193302889	11:118899999-118899999	11:119029289-119029289
7		46;XY;t(16;20)(q23.1;p11.22)	Translocation	Uncertain significance	267924
8		46;XX;inv(2)(q13q14.2)	inversion	Uncertain significance	267990
9	XDH	NM_000379.4(XDH):c.3647C>A (p.Pro1216His)	SNV	Uncertain significance	335760	rs143981573	2:31562482-31562482	2:31339616-31339616
10	XDH	NM_000379.4(XDH):c.1172C>T (p.Pro391Leu)	SNV	Uncertain significance	598996	rs1558697792	2:31602803-31602803	2:31379937-31379937

Sources

Expression for Neutropenia

Search GEO for disease gene expression data for Neutropenia.

Sources

Pathways for Neutropenia

Pathways related to Neutropenia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.02	IL3 CSF3R CSF3 CSF2
2	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	11.52	IL3 CSF3R CSF3 CSF2
3	Hematopoietic Stem Cell Differentiation ¹	11.11	IL3 CSF3 CSF2
4	Hematopoietic cell lineage ³⁶	10.92	IL3 CSF3R CSF3 CSF2
5	Cytokines and Inflammatory Response ¹	10.59	IL3 CSF3 CSF2

Sources

GO Terms for Neutropenia

Biological processes related to Neutropenia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:0019221	9.67	IL3 CSF3R CSF3 CSF2
2	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.5	IL3 HAX1 CSF3
3	drug metabolic process	GO:0017144	9.43	UGT1A1 TPMT
4	positive regulation of actin cytoskeleton reorganization	GO:2000251

Neutropenia

Aliases & Classifications for Neutropenia

MalaCards integrated aliases for Neutropenia:

Classifications:

External Ids:

Summaries for Neutropenia

Related Diseases for Neutropenia

Diseases in the Neutropenia family:

Diseases related to Neutropenia via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Neutropenia via Phenotypic Disease Network (PDN): (show all 45)

Graphical network of the top 20 diseases related to Neutropenia:

Symptoms & Phenotypes for Neutropenia

GenomeRNAi Phenotypes related to Neutropenia according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Neutropenia:

Drugs & Therapeutics for Neutropenia

Drugs for Neutropenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cell-based therapeutics:

Cochrane evidence based reviews: neutropenia

Genetic Tests for Neutropenia

Genetic tests related to Neutropenia:

Anatomical Context for Neutropenia

MalaCards organs/tissues related to Neutropenia:

Publications for Neutropenia

Articles related to Neutropenia:

Genes for Neutropenia

Genes related to Neutropenia (2 elite genes):

Variations for Neutropenia

ClinVar genetic disease variations for Neutropenia:

Expression for Neutropenia

Pathways for Neutropenia

Pathways related to Neutropenia according to GeneCards Suite gene sharing:

GO Terms for Neutropenia

Biological processes related to Neutropenia according to GeneCards Suite gene sharing:

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :