Aliases & Classifications for Neutrophil Migration

MalaCards integrated aliases for Neutrophil Migration:

Name: Neutrophil Migration 58
Neutrophil Chemotactic Response, Abnormal 58
Neutrophil Chemotactic Response; Ncr 58
Neutrophil Chemotactic Response 58
Ncr 58
Nm 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
neutrophil migration:
Inheritance autosomal dominant inheritance


Summaries for Neutrophil Migration

MalaCards based summary : Neutrophil Migration, also known as neutrophil chemotactic response, abnormal, is related to peritonitis and pertussis. An important gene associated with Neutrophil Migration is NM (Neutrophil Migration), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tofacitinib and Fluticasone have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, lung and endothelial, and related phenotypes are immunodeficiency and asthma

Description from OMIM: 162820

Related Diseases for Neutrophil Migration

Diseases related to Neutrophil Migration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 peritonitis 30.0 CXCL8 ICAM1 ITGAM
2 pertussis 29.9 ITGAM ITGB2 MAPK1
3 pulmonary disease, chronic obstructive 29.8 CXCL8 CXCR1 CXCR2
4 bacterial infectious disease 29.6 ITGAM IRAK4 CXCL8
5 arthritis 10.3
6 annular erythema 10.1 ICAM1 ITGB2
7 toxicodendron dermatitis 10.1 CXCL8 ICAM1
8 denture stomatitis 10.1 CXCL8 CXCR1
9 acute respiratory distress syndrome 10.1
10 herpes simplex virus keratitis 10.1 ICAM1 CXCL8
11 hemorrhagic fever 10.1
12 acute pyelonephritis 10.1 CXCL8 CXCR1 CXCR2
13 mooren's ulcer 10.1 ITGB2 ICAM1
14 pneumonia 10.1
15 lymphocytic vasculitis 10.0 ITGAM ICAM1
16 rheumatoid arthritis 10.0
17 cystic fibrosis 10.0
18 bacteriuria 10.0 UMOD CXCR2 CXCR1 CXCL8
19 hepatocellular carcinoma 10.0
20 leukemia, acute myeloid 10.0
21 cervical cancer 10.0
22 noonan syndrome 3 10.0
23 gastric cancer 10.0
24 hematopoietic stem cell transplantation 10.0
25 japanese encephalitis 10.0
26 orchitis 10.0
27 myeloid leukemia 10.0
28 encephalitis 10.0
29 benign childhood occipital epilepsy, panayiotopoulos type 10.0
30 pyelonephritis 10.0 CXCL8 CXCR1 CXCR2 UMOD
31 leukocyte adhesion deficiency, type i 9.9 ICAM1 ITGAM ITGB2
32 shwartzman phenomenon 9.9 ICAM1 ITGAM
33 colitis 9.9
34 ischemia 9.9
35 hyper-ige recurrent infection syndrome 1, autosomal dominant 9.9
36 lepromatous leprosy 9.9
37 onchocerciasis 9.9
38 autoimmune glomerulonephritis 9.8 ICAM1 ITGB2
39 asthma 9.8
40 granuloma annulare 9.8
41 periodontitis 9.8
42 hypoxia 9.8
43 behcet syndrome 9.7
44 breast cancer 9.7
45 otitis media 9.7
46 pulmonary fibrosis, idiopathic 9.7
47 triiodothyronine receptor auxiliary protein 9.7
48 alcoholic hepatitis 9.7
49 burns 9.7
50 crohn's disease 9.7

Graphical network of the top 20 diseases related to Neutrophil Migration:



Diseases related to Neutrophil Migration

Symptoms & Phenotypes for Neutrophil Migration

Human phenotypes related to Neutrophil Migration:

33 (show all 8)
# Description HPO Frequency HPO Source Accession
1 immunodeficiency 33 HP:0002721
2 asthma 33 HP:0002099
3 eczema 33 HP:0000964
4 recurrent bacterial infections 33 HP:0002718
5 recurrent skin infections 33 HP:0001581
6 recurrent fungal infections 33 HP:0002841
7 congenital ichthyosiform erythroderma 33 HP:0007431
8 abnormal leukocyte morphology 33 HP:0001881

Symptoms via clinical synopsis from OMIM:

58
Immune:
immunodeficiency

Skin:
congenital ichthyosis

Clinical features from OMIM:

162820

GenomeRNAi Phenotypes related to Neutrophil Migration according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.35 IRAK4 MAPK3 MYH9 RAC1 RAC2
2 Decreased telomerase activity GR00156-A 8.8 MAPK1 MAPK3 RAC1

MGI Mouse Phenotypes related to Neutrophil Migration:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 CXCR2 ICAM1 IRAK4 ITGAM ITGB2 MAPK1
2 hematopoietic system MP:0005397 9.93 CD177 CXCR1 CXCR2 ICAM1 IRAK4 ITGAM
3 cardiovascular system MP:0005385 9.92 CXCR2 ICAM1 ITGB2 MAPK1 MAPK3 MYH9
4 homeostasis/metabolism MP:0005376 9.7 CXCR2 ICAM1 IRAK4 ITGAM ITGB2 MAPK1
5 immune system MP:0005387 9.44 CD177 CXCR1 CXCR2 ICAM1 IRAK4 ITGAM

Drugs & Therapeutics for Neutrophil Migration

Drugs for Neutrophil Migration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tofacitinib Approved, Investigational Phase 2 477600-75-2
2
Fluticasone Approved, Experimental Phase 2 90566-53-3 62924
3
Azithromycin Approved Phase 2 83905-01-5 55185 447043
4 Protein Kinase Inhibitors Phase 2
5 Peripheral Nervous System Agents Phase 2,Not Applicable
6 Anti-Inflammatory Agents Phase 2,Not Applicable
7 Anti-Infective Agents Phase 2,Not Applicable
8 Cholinergic Antagonists Phase 2
9 Anti-Asthmatic Agents Phase 2
10 Autonomic Agents Phase 2
11 Anti-Allergic Agents Phase 2
12 Anti-Bacterial Agents Phase 2
13 Antibiotics, Antitubercular Phase 2
14 Bronchodilator Agents Phase 2
15 Respiratory System Agents Phase 2
16 Dermatologic Agents Phase 2
17
Ibuprofen Approved Not Applicable 15687-27-1 3672
18
Pioglitazone Approved, Investigational Not Applicable 111025-46-8 4829
19
Simvastatin Approved Not Applicable 79902-63-9 54454
20
tannic acid Approved Not Applicable 1401-55-4
21
Caffeine Approved Not Applicable 58-08-2 2519
22
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
23
Ethanol Approved Not Applicable 64-17-5 702
24
Sulforaphane Investigational Not Applicable 4478-93-7, 142825-10-3 5350
25 Antirheumatic Agents Not Applicable
26 Analgesics, Non-Narcotic Not Applicable
27 Analgesics Not Applicable
28 Lipid Regulating Agents Not Applicable
29 Anticholesteremic Agents Not Applicable
30 Hydroxymethylglutaryl-CoA Reductase Inhibitors Not Applicable
31 Hypoglycemic Agents Not Applicable
32 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
33 Hypolipidemic Agents Not Applicable
34 Cyclooxygenase Inhibitors Not Applicable
35 Antimetabolites Not Applicable
36 Protective Agents Not Applicable
37 Sulforafan Not Applicable
38 Phosphodiesterase Inhibitors Not Applicable
39 Central Nervous System Stimulants Not Applicable
40 Purinergic P1 Receptor Antagonists Not Applicable
41 Central Nervous System Depressants Not Applicable
42 Anti-Infective Agents, Local Not Applicable
43 Neurotransmitter Agents Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 The Safety And Efficacy Of Maintenance Therapy With CP-690,550 Completed NCT01393899 Phase 2 Placebo;CP-690,550;CP-690,550
2 A Study To Investigate Safety And Efficacy Of CP-690,550 For Induction Therapy In Subjects With Moderate To Severe Crohn's Disease Completed NCT01393626 Phase 2 Placebo;CP-690,550;CP-690,550
3 A Study To Investigate The Safety And Efficacy Of CP- 690,550 In Patients With Moderate And Severe Ulcerative Colitis. Completed NCT00787202 Phase 2 CP- 690 550;CP- 690 550;CP- 690 550;CP- 690 550
4 A Open-Label Study Of CP-690,550 As Long-Term Therapy (48 Weeks) In Subjects With Crohn's Disease Completed NCT01470599 Phase 2 CP-690,550;CP-690,550
5 A Study To Investigate The Safety And Possible Clinical Benefit Of Multistem(r) In Patients With Moderate To Severe Ulcerative Colitis Completed NCT01240915 Phase 2 placebo;MultiStem low dose;placebo;MultiStem low dose;placebo;MultiStem high dose;placebo;MultiStem high dose;placebo;MultiStem high dose;placebo;MultiStem high dose
6 Long-Term Study of the Effects of Navarixin (SCH 527123, MK-7123) in Participants With Moderate to Severe COPD (MK-7123-019) Terminated NCT01006616 Phase 2 Navarixin;Placebo;Rescue medication
7 Bronchiectasis in Chronic Obstructive Pulmonary Disease (COPD) Patients: Role of Prophylaxis Terminated NCT00524095 Phase 2 azithromycin and fluticasone;fluticasone and azithromycin
8 Study of SCH 527123 in Subjects With Severe Asthma (Study P05109AM1) Withdrawn NCT01006161 Phase 2 SCH 527123;SCH 527123;SCH 527123;SCH 527123
9 Pilot Mouthwash Study of Pioglitazone and Simvastatin in Healthy Volunteers Completed NCT00531882 Not Applicable Pioglitazone;Simvastatin;Ibuprofen
10 Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation Completed NCT01315665 Not Applicable
11 Assessment of the Predictive Value of Fecal Calprotectin for the Outcome of Severe Alcoholic Hepatitis Completed NCT02808663 Not Applicable
12 Leukocyte Function in Asthma and COPD Completed NCT00147069
13 Influence of Lifestyle Factors on Neutrophil Migration Pilot Study Recruiting NCT02411318 Not Applicable ProLab 200mg caffeine capsule
14 Resistin in Septic Shock and Acute Kidney Injury Recruiting NCT03146546
15 Microfluidic Assessment of Clinical Outcomes in Preterm Newborns Recruiting NCT03291496
16 Effects of Resistin on Neutrophil Function Withdrawn NCT03626870

Search NIH Clinical Center for Neutrophil Migration

Genetic Tests for Neutrophil Migration

Anatomical Context for Neutrophil Migration

MalaCards organs/tissues related to Neutrophil Migration:

42
Neutrophil, Lung, Endothelial, Skin, Kidney, Liver, Monocytes

Publications for Neutrophil Migration

Articles related to Neutrophil Migration:

(show top 50) (show all 608)
# Title Authors Year
1
Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation. ( 30696624 )
2019
2
Photobiomodulation reduces neutrophil migration and oxidative stress in mice with carrageenan-induced peritonitis. ( 29951878 )
2018
3
Matrix Metalloproteinase-9-Generated COOH-, but Not NH<sub>2</sub>-Terminal Fragments of Serum Amyloid A1 Retain Potentiating Activity in Neutrophil Migration to CXCL8, With Loss of Direct Chemotactic and Cytokine-Inducing Capacity. ( 29915572 )
2018
4
<i>In vivo</i> imaging of hepatic neutrophil migration in severe alcoholic hepatitis with <sup>111</sup>In-radiolabelled leucocytes. ( 29700216 )
2018
5
Mechanochemical modeling of neutrophil migration based on four signaling layers, integrin dynamics, and substrate stiffness. ( 29968162 )
2018
6
Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection. ( 29976647 )
2018
7
Exosomes derived from calcium oxalate-exposed macrophages enhance IL-8 production from renal cells, neutrophil migration and crystal invasion through extracellular matrix. ( 29953960 )
2018
8
Leptin Mediates <i>In Vivo</i> Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1. ( 29467755 )
2018
9
Lipid rafta89associated I^a89adducin participates in neutrophil migration. ( 29901076 )
2018
10
Myosin 1f is specifically required for neutrophil migration in 3D environments during acute inflammation. ( 29487067 )
2018
11
Myo1f is critical for neutrophil migration in vivo. ( 29699992 )
2018
12
A Fundamental Role of Myh9 for Neutrophil Migration in Innate Immunity. ( 30068598 )
2018
13
Neutrophil Migration and Adhesion Molecule Expression after Acute High-Intensity Street Dance Exercise. ( 30069484 )
2018
14
Resistin exerts a beneficial role in atherosclerotic plaque inflammation by inhibiting neutrophil migration. ( 30075966 )
2018
15
Systemic neutrophil migration and rapid consumption of neutrophils in the spleen. ( 30211259 )
2018
16
Trimetazidine Attenuates Cardiac Dysfunction in Endotoxemia and Sepsis by Promoting Neutrophil Migration. ( 30233596 )
2018
17
Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults. ( 30300408 )
2018
18
Unique pattern of neutrophil migration and function during tumor progression. ( 30323345 )
2018
19
Outer Membrane Vesicles Derived From Escherichia coli Regulate Neutrophil Migration by Induction of Endothelial IL-8. ( 30369908 )
2018
20
Direct Inhibitory Effect of the Phosphodiesterase-4 Inhibitor, Roflumilast, on Neutrophil Migration in COPD. ( 30395484 )
2018
21
IL-17/IL-17R axis elicits intestinal neutrophil migration, restrains gut dysbiosis and LPS translocation in high-fat diet-induced metabolic syndrome model. ( 30472727 )
2018
22
Nuclear Deformation During Neutrophil Migration at Sites of Inflammation. ( 30505310 )
2018
23
LL-37 and its analog FF/CAP18 attenuate neutrophil migration in sepsis-induced acute lung injury. ( 30537236 )
2018
24
Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta. ( 30538702 )
2018
25
Effects of Azithromycin on Behavior, Pathologic Signs, and Changes in Cytokines, Chemokines, and Neutrophil Migration in C57BL/6 Mice Exposed to Dextran Sulfate Sodium. ( 30545428 )
2018
26
The Neutrophil Nucleus: An Important Influence on Neutrophil Migration and Function. ( 30564248 )
2018
27
LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux. ( 30590048 )
2018
28
Inhibition of neutrophil migration and reduction of oxidative stress by ethyl p-coumarate in acute and chronic inflammatory models. ( 30668327 )
2018
29
Modeling neutrophil migration in dynamic chemoattractant gradients: assessing the role of exosomes during signal relay. ( 28954858 )
2017
30
Role of the glucocorticoid-induced leucine zipper gene in dexamethasone-induced inhibition of mouse neutrophil migration<i>via</i>control of annexin A1 expression. ( 28373208 )
2017
31
Response by Mittal et al to Letter Regarding Article, &amp;quot;Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury&amp;quot;. ( 29217714 )
2017
32
Elucidation of Distinct Roles of Guinea Pig CXCR1 and CXCR2 in Neutrophil Migration toward IL-8 and GROI+ by Specific Antibodies. ( 28458362 )
2017
33
Letter by Gagat and Grzanka Regarding Article, &amp;quot;Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury&amp;quot;. ( 29217713 )
2017
34
Mechanisms of Impaired Neutrophil Migration by MicroRNAs in Myelodysplastic Syndromes. ( 28130497 )
2017
35
Protective effect of Galectin-9 in murine model of lung emphysema: Involvement of neutrophil migration and MMP-9 production. ( 28704475 )
2017
36
SiMA: A simplified migration assay for analyzing neutrophil migration. ( 28544679 )
2017
37
Anti-inflammatory effect of the monoterpene myrtenol is dependent on the direct modulation of neutrophil migration and oxidative stress. ( 28559105 )
2017
38
The stromal cell-derived factor 1/C-X-C chemokine receptor type 4 axis is important in neutrophil migration caused by cardiopulmonary bypass in children. ( 29106576 )
2017
39
Cxcl8b and Cxcr2 Regulate Neutrophil Migration through Bloodstream in Zebrafish. ( 28642884 )
2017
40
The F0F1 ATP synthase regulates human neutrophil migration through cytoplasmic proton extrusion coupled with ATP generation. ( 28843171 )
2017
41
Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration. ( 28191674 )
2017
42
IL-20 Signaling in Activated Human Neutrophils Inhibits Neutrophil Migration and Function. ( 28424238 )
2017
43
CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration<i>In Vivo</i>through Interference with Glycosaminoglycan Interactions. ( 28539925 )
2017
44
PRO-RESOLUTION POTENCY OF RESOLVINS D1, D2 AND E1 ON NEUTROPHIL MIGRATION AND IN DERMAL WOUND HEALING. ( 29552232 )
2017
45
Activating Integrins Isn't Always &amp;quot;Beta&amp;quot; for Neutrophil Migration! ( 28459388 )
2017
46
Chemorepellent Semaphorin 3E Negatively Regulates Neutrophil Migration In Vitro and In Vivo. ( 27913633 )
2017
47
CD177 modulates human neutrophil migration through activation- mediated integrin and chemoreceptor regulation. ( 28807980 )
2017
48
GI^1 is required for neutrophil migration in zebrafish. ( 28554852 )
2017
49
Novel roles for podocalyxin in regulating stress myelopoiesis, Rap1a, and neutrophil migration. ( 28408238 )
2017
50
Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury. ( 28790198 )
2017

Variations for Neutrophil Migration

Expression for Neutrophil Migration

Search GEO for disease gene expression data for Neutrophil Migration.

Pathways for Neutrophil Migration

Pathways related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CD177 CXCL8 CXCR1 CXCR2 ICAM1 IRAK4
2
Show member pathways
13.8 CXCL8 CXCR1 CXCR2 IRAK4 ITGAM ITGB2
3
Show member pathways
13.56 CXCL8 ICAM1 ITGAM ITGB2 MAPK1 MAPK3
4
Show member pathways
13.43 CXCL8 CXCR1 CXCR2 IRAK4 ITGAM ITGB2
5
Show member pathways
13.4 CXCL8 ICAM1 IRAK4 ITGAM ITGB2 MAPK1
6
Show member pathways
13.34 CD177 ITGAM ITGB2 MAPK1 MAPK3 RAC1
7
Show member pathways
13.31 CXCL8 CXCR1 CXCR2 MAPK1 MAPK3 MYH9
8
Show member pathways
13.21 CXCL8 IRAK4 MAPK1 MAPK3 RAC1
9
Show member pathways
13.2 CXCL8 CXCR1 CXCR2 ICAM1 ITGAM ITGB2
10
Show member pathways
13.11 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
11
Show member pathways
13.05 MAPK1 MAPK3 MYH9 RAC1 RAC2
12
Show member pathways
13.02 ITGAM ITGB2 MYH9 RAC1 RAC2
13
Show member pathways
12.94 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
14
Show member pathways
12.91 ITGAM MAPK1 MAPK3 RAC1 RAC2
15
Show member pathways
12.91 ITGAM ITGB2 MAPK1 MAPK3 MYH9 RAC1
16
Show member pathways
12.9 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
17
Show member pathways
12.89 CXCL8 CXCR2 ICAM1 IRAK4 MAPK1 MAPK3
18 12.88 CXCL8 MAPK1 MAPK3 RAC1 RAC2
19
Show member pathways
12.87 CXCL8 ICAM1 ITGB2 MAPK1 MAPK3 RAC1
20
Show member pathways
12.86 CXCL8 CXCR1 CXCR2 MAPK1 MAPK3 RAC1
21
Show member pathways
12.85 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
22
Show member pathways
12.85 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
23 12.82 IRAK4 MAPK1 MAPK3 RAC1 RAC2
24
Show member pathways
12.77 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
25
Show member pathways
12.7 ICAM1 ITGAM ITGB2 RAC1 RAC2
26
Show member pathways
12.64 MAPK1 MAPK3 MYH9 RAC1
27
Show member pathways
12.64 CXCL8 ICAM1 IRAK4 MAPK1 MAPK3
28
Show member pathways
12.62 MAPK1 MAPK3 RAC1 RAC2
29 12.57 ITGB2 MYH9 RAC1 RAC2
30
Show member pathways
12.56 MAPK1 MAPK3 RAC1 RAC2
31 12.54 ITGAM ITGB2 MAPK1 MAPK3 MYH9 RAC1
32
Show member pathways
12.52 CXCL8 CXCR1 CXCR2 RAC1
33
Show member pathways
12.49 IRAK4 MAPK1 MAPK3 RAC1
34
Show member pathways
12.49 ICAM1 ITGB2 MAPK1 MAPK3 RAC1 RAC2
35
Show member pathways
12.47 ICAM1 MAPK1 MAPK3 RAC1
36
Show member pathways
12.47 ITGAM ITGB2 MAPK1 MAPK3
37
Show member pathways
12.46 IRAK4 MAPK1 MAPK3 RAC1
38
Show member pathways
12.45 ICAM1 MAPK1 MAPK3 RAC1
39
Show member pathways
12.45 MAPK1 MAPK3 RAC1 RAC2
40
Show member pathways
12.44 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
41
Show member pathways
12.43 MAPK1 MAPK3 RAC1 RAC2
42
Show member pathways
12.39 MAPK1 MAPK3 RAC1 RAC2
43 12.38 MAPK1 MAPK3 RAC1 RAC2
44
Show member pathways
12.37 CXCL8 IRAK4 MAPK1 MAPK3 RAC1
45
Show member pathways
12.36 MAPK1 MAPK3 MYH9 RAC1
46
Show member pathways
12.3 CXCL8 CXCR1 CXCR2 MAPK1 MAPK3 RAC1
47 12.29 MAPK1 MAPK3 RAC1 RAC2
48
Show member pathways
12.29 MAPK1 MAPK3 RAC1 RAC2
49
Show member pathways
12.29 IRAK4 ITGAM ITGB2 MAPK1 MAPK3
50
Show member pathways
12.28 CXCL8 IRAK4 MAPK1 MAPK3

GO Terms for Neutrophil Migration

Cellular components related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.77 CXCR1 CXCR2 ICAM1 ITGAM ITGB2
2 plasma membrane GO:0005886 9.77 CD177 CXCR1 CXCR2 ICAM1 IRAK4 ITGAM
3 membrane raft GO:0045121 9.71 CD177 ICAM1 ITGAM ITGB2
4 specific granule membrane GO:0035579 9.65 CD177 ITGAM ITGB2
5 tertiary granule membrane GO:0070821 9.63 CD177 ITGAM ITGB2
6 pseudopodium GO:0031143 9.49 MAPK1 MAPK3
7 secretory granule membrane GO:0030667 9.46 CD177 CXCR1 CXCR2 RAC1
8 plasma membrane raft GO:0044853 9.43 CD177 ITGAM ITGB2
9 integrin alphaM-beta2 complex GO:0034688 9.32 ITGAM ITGB2
10 focal adhesion GO:0005925 9.17 ICAM1 ITGB2 MAPK1 MAPK3 MYH9 RAC1
11 extracellular exosome GO:0070062 10.03 CD177 ICAM1 ITGAM ITGB2 MYH9 RAC1

Biological processes related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.91 CXCL8 ICAM1 IRAK4 ITGAM ITGB2
2 neutrophil degranulation GO:0043312 9.91 CD177 CXCR1 CXCR2 ITGAM ITGB2 MAPK1
3 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 9.89 MAPK1 MAPK3 RAC1
4 Fc-epsilon receptor signaling pathway GO:0038095 9.87 MAPK1 MAPK3 RAC1
5 phagocytosis, engulfment GO:0006911 9.86 ITGAM ITGB2 MYH9
6 integrin-mediated signaling pathway GO:0007229 9.85 ITGAM ITGB2 MYH9
7 cellular response to tumor necrosis factor GO:0071356 9.85 CXCL8 ICAM1 MAPK1 MAPK3
8 leukocyte migration GO:0050900 9.85 CD177 ICAM1 ITGAM ITGB2 MYH9
9 calcium-mediated signaling GO:0019722 9.84 CXCL8 CXCR1 CXCR2
10 chemokine-mediated signaling pathway GO:0070098 9.82 CXCL8 CXCR1 CXCR2
11 neutrophil chemotaxis GO:0030593 9.8 CXCL8 CXCR1 CXCR2 ITGB2
12 cellular response to organic substance GO:0071310 9.75 ICAM1 MAPK1 MAPK3
13 lung morphogenesis GO:0060425 9.71 MAPK1 MAPK3
14 Rac protein signal transduction GO:0016601 9.71 RAC1 RAC2
15 cell projection assembly GO:0030031 9.71 RAC1 RAC2
16 positive regulation of lamellipodium assembly GO:0010592 9.71 RAC1 RAC2
17 receptor internalization GO:0031623 9.71 CXCL8 CXCR1 CXCR2 ITGB2
18 microglial cell activation GO:0001774 9.7 ITGAM ITGB2
19 face development GO:0060324 9.7 MAPK1 MAPK3
20 dendritic cell chemotaxis GO:0002407 9.69 CXCR1 CXCR2
21 positive regulation of telomere capping GO:1904355 9.69 MAPK1 MAPK3
22 toll-like receptor 4 signaling pathway GO:0034142 9.69 ITGAM ITGB2
23 cellular response to dopamine GO:1903351 9.68 MAPK1 MAPK3
24 regulation of ossification GO:0030278 9.68 MAPK1 MAPK3
25 amyloid-beta clearance GO:0097242 9.68 ITGAM ITGB2
26 neutrophil activation GO:0042119 9.67 CXCL8 CXCR2
27 outer ear morphogenesis GO:0042473 9.66 MAPK1 MAPK3
28 positive regulation of microglial cell activation GO:1903980 9.66 ITGAM ITGB2
29 regulation of stress-activated MAPK cascade GO:0032872 9.65 MAPK1 MAPK3
30 acute inflammatory response to antigenic stimulus GO:0002438 9.65 CXCR2 ICAM1
31 Bergmann glial cell differentiation GO:0060020 9.65 MAPK1 MAPK3
32 positive regulation of superoxide anion generation GO:0032930 9.65 CD177 ITGAM ITGB2
33 regulation of early endosome to late endosome transport GO:2000641 9.64 MAPK1 MAPK3
34 trachea formation GO:0060440 9.63 MAPK1 MAPK3
35 caveolin-mediated endocytosis GO:0072584 9.62 MAPK1 MAPK3
36 regulation of cellular pH GO:0030641 9.62 MAPK1 MAPK3
37 leukocyte cell-cell adhesion GO:0007159 9.62 CD177 ICAM1 ITGB2 UMOD
38 regulation of hydrogen peroxide metabolic process GO:0010310 9.61 RAC1 RAC2
39 negative regulation of dopamine metabolic process GO:0045963 9.61 ITGAM ITGB2
40 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.61 CD177 ITGAM ITGB2
41 regulation of Golgi inheritance GO:0090170 9.6 MAPK1 MAPK3
42 regulation of respiratory burst GO:0060263 9.59 RAC1 RAC2
43 response to epidermal growth factor GO:0070849 9.58 MAPK1 MAPK3
44 cardiac neural crest cell development involved in heart development GO:0061308 9.57 MAPK1 MAPK3
45 positive regulation of prostaglandin-E synthase activity GO:2000363 9.56 ITGAM ITGB2
46 interleukin-8-mediated signaling pathway GO:0038112 9.52 CXCR1 CXCR2
47 positive regulation of neutrophil chemotaxis GO:0090023 9.46 CXCL8 CXCR2 RAC1 RAC2
48 positive regulation of neutrophil degranulation GO:0043315 9.43 CD177 ITGAM ITGB2
49 chemotaxis GO:0006935 9.43 CXCL8 CXCR1 CXCR2 MAPK1 RAC1 RAC2
50 neutrophil migration GO:1990266 8.92 CD177 IRAK4 ITGB2 UMOD

Molecular functions related to Neutrophil Migration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase activity GO:0004708 9.4 MAPK1 MAPK3
2 MAP kinase activity GO:0004707 9.37 MAPK1 MAPK3
3 C-X-C chemokine receptor activity GO:0016494 9.32 CXCR1 CXCR2
4 complement component C3b binding GO:0001851 9.26 ITGAM ITGB2
5 integrin binding GO:0005178 9.26 CD177 ICAM1 ITGB2 MYH9
6 interleukin-8 binding GO:0019959 9.16 CXCR1 CXCR2
7 interleukin-8 receptor activity GO:0004918 8.62 CXCR1 CXCR2

Sources for Neutrophil Migration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....