Aliases & Classifications for Neutrophil Migration

MalaCards integrated aliases for Neutrophil Migration:

Name: Neutrophil Migration 57
Neutrophil Chemotactic Response, Abnormal 57
Neutrophil Chemotactic Response; Ncr 57
Neutrophil Chemotactic Response 57
Ncr 57
Nm 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
neutrophil migration:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 57 162820
MedGen 42 C0312860

Summaries for Neutrophil Migration

MalaCards based summary : Neutrophil Migration, also known as neutrophil chemotactic response, abnormal, is related to peritonitis and bacteriuria. An important gene associated with Neutrophil Migration is NM (Neutrophil Migration), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tofacitinib and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, endothelial and lung, and related phenotypes are immunodeficiency and congenital ichthyosiform erythroderma

Description from OMIM: 162820

Related Diseases for Neutrophil Migration

Diseases related to Neutrophil Migration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 peritonitis 29.4 CXCL8 ICAM1 ITGAM
2 bacteriuria 10.3 CXCL8 CXCR1 CXCR2
3 acute pyelonephritis 10.2 CXCL8 CXCR1 CXCR2
4 denture stomatitis 10.2 CXCL8 CXCR1
5 annular erythema 10.2 ICAM1 ITGB2
6 toxicodendron dermatitis 10.1 CXCL8 ICAM1
7 herpes simplex virus keratitis 10.1 CXCL8 ICAM1
8 endotheliitis 10.1
9 pertussis 10.0 ITGAM ITGB2 MAPK1
10 mooren's ulcer 10.0 ICAM1 ITGB2
11 pyelonephritis 10.0 CXCL8 CXCR1 CXCR2 UMOD
12 lymphocytic vasculitis 9.9 ICAM1 ITGAM
13 leukemia, acute myeloid 9.8
14 cervical cancer 9.8
15 gastric cancer 9.8
16 myeloid leukemia 9.8
17 hyper-ige recurrent infection syndrome, autosomal dominant 9.7
18 cystic fibrosis 9.7
19 asthma 9.7
20 arthritis 9.7
21 hepatitis 9.7
22 wegener granulomatosis 9.6 CD177 CXCL8 ITGAM ITGB2
23 pulmonary disease, chronic obstructive 9.6 CXCL8 CXCR1 CXCR2
24 otitis media 9.6
25 rheumatoid arthritis 9.6
26 myelodysplastic syndrome 9.6
27 alcoholic hepatitis 9.6
28 granuloma annulare 9.6
29 inflammatory bowel disease 9.6
30 mucositis 9.6
31 asbestosis 9.6
32 pulmonary edema 9.6
33 listeriosis 9.6
34 aseptic meningitis 9.6
35 histoplasmosis 9.6
36 gingivitis 9.6
37 ischemia 9.6
38 necrobiosis lipoidica 9.6
39 pneumonia 9.6
40 periodontitis 9.6
41 vasculitis 9.6
42 psoriasis 9.6
43 allergic asthma 9.6
44 meningitis 9.6
45 sickle cell disease 9.6
46 hypoxia 9.6
47 chronic kidney failure 9.1 ICAM1 MYH9 UMOD

Graphical network of the top 20 diseases related to Neutrophil Migration:



Diseases related to Neutrophil Migration

Symptoms & Phenotypes for Neutrophil Migration

Symptoms via clinical synopsis from OMIM:

57
Skin:
congenital ichthyosis

Immune:
immunodeficiency


Clinical features from OMIM:

162820

Human phenotypes related to Neutrophil Migration:

32
# Description HPO Frequency HPO Source Accession
1 immunodeficiency 32 HP:0002721
2 congenital ichthyosiform erythroderma 32 HP:0007431

GenomeRNAi Phenotypes related to Neutrophil Migration according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.35 IRAK4 MAPK3 MYH9 RAC1 RAC2
2 Decreased telomerase activity GR00156-A 8.8 MAPK1 MAPK3 RAC1

MGI Mouse Phenotypes related to Neutrophil Migration:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 RAC1 IRAK4 ITGAM RAC2 ITGB2 UMOD
2 hematopoietic system MP:0005397 9.93 RAC1 IRAK4 ITGAM RAC2 ITGB2 MAPK1
3 cardiovascular system MP:0005385 9.92 RAC1 RAC2 ITGB2 MAPK1 MAPK3 CXCR2
4 homeostasis/metabolism MP:0005376 9.7 RAC1 IRAK4 ITGAM RAC2 ITGB2 UMOD
5 immune system MP:0005387 9.44 ITGAM RAC2 ITGB2 UMOD MAPK1 CD177

Drugs & Therapeutics for Neutrophil Migration

Drugs for Neutrophil Migration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tofacitinib Approved, Investigational Phase 2 477600-75-2
2
Azithromycin Approved Phase 2 83905-01-5 55185 447043
3
Fluticasone Approved, Experimental, Investigational Phase 2 90566-53-3 62924
4 Protein Kinase Inhibitors Phase 2
5 Anti-Inflammatory Agents Phase 2,Not Applicable
6 Peripheral Nervous System Agents Phase 2,Not Applicable
7 Anti-Infective Agents Phase 2,Not Applicable
8 Cholinergic Antagonists Phase 2
9 Anti-Allergic Agents Phase 2
10 Anti-Asthmatic Agents Phase 2
11 Anti-Bacterial Agents Phase 2
12 Antibiotics, Antitubercular Phase 2
13 Autonomic Agents Phase 2
14 Bronchodilator Agents Phase 2
15 Dermatologic Agents Phase 2
16 Respiratory System Agents Phase 2
17
Ibuprofen Approved Not Applicable 15687-27-1 3672
18
Pioglitazone Approved, Investigational Not Applicable 111025-46-8 4829
19
Simvastatin Approved Not Applicable 79902-63-9 54454
20
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
21
Ethanol Approved Not Applicable 64-17-5 702
22
Caffeine Approved, Nutraceutical Not Applicable 58-08-2 2519
23 tannic acid Approved, Nutraceutical Not Applicable
24 Analgesics Not Applicable
25 Analgesics, Non-Narcotic Not Applicable
26 Anticholesteremic Agents Not Applicable
27 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
28 Antimetabolites Not Applicable
29 Antirheumatic Agents Not Applicable
30 Cyclooxygenase Inhibitors Not Applicable
31 Hydroxymethylglutaryl-CoA Reductase Inhibitors Not Applicable
32 Hypoglycemic Agents Not Applicable
33 Hypolipidemic Agents Not Applicable
34 Lipid Regulating Agents Not Applicable
35 Protective Agents Not Applicable
36 Sulforafan Not Applicable
37 Anti-Infective Agents, Local Not Applicable
38 Central Nervous System Depressants Not Applicable
39 Central Nervous System Stimulants Not Applicable
40 Neurotransmitter Agents Not Applicable
41 Phosphodiesterase Inhibitors Not Applicable
42 Purinergic P1 Receptor Antagonists Not Applicable
43
Sulforaphane Investigational, Nutraceutical Not Applicable 142825-10-3, 4478-93-7 5350

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 The Safety And Efficacy Of Maintenance Therapy With CP-690,550 Completed NCT01393899 Phase 2 Placebo;CP-690,550;CP-690,550
2 A Study To Investigate Safety And Efficacy Of CP-690,550 For Induction Therapy In Subjects With Moderate To Severe Crohn's Disease Completed NCT01393626 Phase 2 Placebo;CP-690,550;CP-690,550
3 A Study To Investigate The Safety And Efficacy Of CP- 690,550 In Patients With Moderate And Severe Ulcerative Colitis. Completed NCT00787202 Phase 2 CP- 690 550;CP- 690 550;CP- 690 550;CP- 690 550
4 A Open-Label Study Of CP-690,550 As Long-Term Therapy (48 Weeks) In Subjects With Crohn's Disease Completed NCT01470599 Phase 2 CP-690,550;CP-690,550
5 A Study To Investigate The Safety And Possible Clinical Benefit Of Multistem(r) In Patients With Moderate To Severe Ulcerative Colitis Completed NCT01240915 Phase 2 placebo;MultiStem low dose;placebo;MultiStem low dose;placebo;MultiStem high dose;placebo;MultiStem high dose;placebo;MultiStem high dose;placebo;MultiStem high dose
6 Long-Term Study of the Effects of Navarixin (SCH 527123, MK-7123) in Participants With Moderate to Severe COPD (MK-7123-019) Terminated NCT01006616 Phase 2 Navarixin;Placebo;Rescue medication
7 Bronchiectasis in Chronic Obstructive Pulmonary Disease (COPD) Patients: Role of Prophylaxis Terminated NCT00524095 Phase 2 azithromycin and fluticasone;fluticasone and azithromycin
8 Study of SCH 527123 in Subjects With Severe Asthma (Study P05109AM1) Withdrawn NCT01006161 Phase 2 SCH 527123;SCH 527123;SCH 527123;SCH 527123
9 Pilot Mouthwash Study of Pioglitazone and Simvastatin in Healthy Volunteers Completed NCT00531882 Not Applicable Pioglitazone;Simvastatin;Ibuprofen
10 Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation Completed NCT01315665 Not Applicable
11 Assessment of the Predictive Value of Fecal Calprotectin for the Outcome of Severe Alcoholic Hepatitis Completed NCT02808663 Not Applicable
12 Leukocyte Function in Asthma and COPD Completed NCT00147069
13 Influence of Lifestyle Factors on Neutrophil Migration Pilot Study Recruiting NCT02411318 Not Applicable ProLab 200mg caffeine capsule
14 Resistin in Septic Shock and Acute Kidney Injury Recruiting NCT03146546
15 Microfluidic Assessment of Clinical Outcomes in Preterm Newborns Recruiting NCT03291496

Search NIH Clinical Center for Neutrophil Migration

Genetic Tests for Neutrophil Migration

Anatomical Context for Neutrophil Migration

MalaCards organs/tissues related to Neutrophil Migration:

41
Neutrophil, Endothelial, Lung, Kidney, Liver, Monocytes, Small Intestine

Publications for Neutrophil Migration

Articles related to Neutrophil Migration:

(show top 50) (show all 155)
# Title Authors Year
1
Photobiomodulation reduces neutrophil migration and oxidative stress in mice with carrageenan-induced peritonitis. ( 29951878 )
2018
2
Matrix Metalloproteinase-9-Generated COOH-, but Not NH<sub>2</sub>-Terminal Fragments of Serum Amyloid A1 Retain Potentiating Activity in Neutrophil Migration to CXCL8, With Loss of Direct Chemotactic and Cytokine-Inducing Capacity. ( 29915572 )
2018
3
<i>In vivo</i> imaging of hepatic neutrophil migration in severe alcoholic hepatitis with <sup>111</sup>In-radiolabelled leucocytes. ( 29700216 )
2018
4
Mechanochemical modeling of neutrophil migration based on four signaling layers, integrin dynamics, and substrate stiffness. ( 29968162 )
2018
5
Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection. ( 29976647 )
2018
6
Exosomes derived from calcium oxalate-exposed macrophages enhance IL-8 production from renal cells, neutrophil migration and crystal invasion through extracellular matrix. ( 29953960 )
2018
7
Leptin Mediates <i>In Vivo</i> Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1. ( 29467755 )
2018
8
Lipid rafta89associated I^a89adducin participates in neutrophil migration. ( 29901076 )
2018
9
Myosin 1f is specifically required for neutrophil migration in 3D environments during acute inflammation. ( 29487067 )
2018
10
Myo1f is critical for neutrophil migration in vivo. ( 29699992 )
2018
11
Modeling neutrophil migration in dynamic chemoattractant gradients: assessing the role of exosomes during signal relay. ( 28954858 )
2017
12
Role of the glucocorticoid-induced leucine zipper gene in dexamethasone-induced inhibition of mouse neutrophil migration<i>via</i>control of annexin A1 expression. ( 28373208 )
2017
13
Response by Mittal et al to Letter Regarding Article, &amp;quot;Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury&amp;quot;. ( 29217714 )
2017
14
Elucidation of Distinct Roles of Guinea Pig CXCR1 and CXCR2 in Neutrophil Migration toward IL-8 and GROI+ by Specific Antibodies. ( 28458362 )
2017
15
Letter by Gagat and Grzanka Regarding Article, &amp;quot;Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury&amp;quot;. ( 29217713 )
2017
16
Mechanisms of Impaired Neutrophil Migration by MicroRNAs in Myelodysplastic Syndromes. ( 28130497 )
2017
17
Protective effect of Galectin-9 in murine model of lung emphysema: Involvement of neutrophil migration and MMP-9 production. ( 28704475 )
2017
18
SiMA: A simplified migration assay for analyzing neutrophil migration. ( 28544679 )
2017
19
Anti-inflammatory effect of the monoterpene myrtenol is dependent on the direct modulation of neutrophil migration and oxidative stress. ( 28559105 )
2017
20
The stromal cell-derived factor 1/C-X-C chemokine receptor type 4 axis is important in neutrophil migration caused by cardiopulmonary bypass in children. ( 29106576 )
2017
21
Cxcl8b and Cxcr2 Regulate Neutrophil Migration through Bloodstream in Zebrafish. ( 28642884 )
2017
22
The F0F1 ATP synthase regulates human neutrophil migration through cytoplasmic proton extrusion coupled with ATP generation. ( 28843171 )
2017
23
Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration. ( 28191674 )
2017
24
IL-20 Signaling in Activated Human Neutrophils Inhibits Neutrophil Migration and Function. ( 28424238 )
2017
25
CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration<i>In Vivo</i>through Interference with Glycosaminoglycan Interactions. ( 28539925 )
2017
26
PRO-RESOLUTION POTENCY OF RESOLVINS D1, D2 AND E1 ON NEUTROPHIL MIGRATION AND IN DERMAL WOUND HEALING. ( 29552232 )
2017
27
Activating Integrins Isn't Always &amp;quot;Beta&amp;quot; for Neutrophil Migration! ( 28459388 )
2017
28
Chemorepellent Semaphorin 3E Negatively Regulates Neutrophil Migration In Vitro and In Vivo. ( 27913633 )
2017
29
CD177 modulates human neutrophil migration through activation- mediated integrin and chemoreceptor regulation. ( 28807980 )
2017
30
GI^1 is required for neutrophil migration in zebrafish. ( 28554852 )
2017
31
NET-producing CD16(high) CD62L(dim) neutrophils migrate to tumor sites and predict improved survival in patients with HNSCC. ( 28247912 )
2017
32
Novel roles for podocalyxin in regulating stress myelopoiesis, Rap1a, and neutrophil migration. ( 28408238 )
2017
33
Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury. ( 28790198 )
2017
34
A Radical Break: Restraining Neutrophil Migration. ( 27623379 )
2016
35
Oxidant Sensing by TRPM2 Inhibits Neutrophil Migration and Mitigates Inflammation. ( 27569419 )
2016
36
Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. ( 27280401 )
2016
37
Cannabinoid Receptor Type 2 Agonist Attenuates Acute Neurogenic Pulmonary Edema by Preventing Neutrophil Migration after Subarachnoid Hemorrhage in Rats. ( 26463937 )
2016
38
IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration. ( 26653800 )
2016
39
Activated protein C inhibits neutrophil migration in allergic asthma: a randomised trial. ( 26381519 )
2015
40
The physiological roles of ICAM-1 and ICAM-2 in neutrophil migration into tissues. ( 25427141 )
2015
41
MFG-E8 inhibits neutrophil migration through I+vI^a88-integrin-dependent MAP kinase activation. ( 25936372 )
2015
42
Impairment of neutrophil migration to remote inflammatory site during lung histoplasmosis. ( 25710004 )
2015
43
In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (I'-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation. ( 25515270 )
2015
44
TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8. ( 24501198 )
2014
45
Pulmonary endothelial protein kinase C-delta (PKCI') regulates neutrophil migration in acute lung inflammation. ( 24211111 )
2014
46
Phosphatase Wip1 negatively regulates neutrophil migration and inflammation. ( 24395919 )
2014
47
Growth Arrest-Specific Protein 6 (Gas6) Attenuates Neutrophil Migration and Acute Lung Injury in Sepsis. ( 24088986 )
2013
48
NDP-MSH inhibits neutrophil migration through nicotinic and adrenergic receptors in experimental peritonitis. ( 23338711 )
2013
49
c-Abl tyrosine kinase plays a critical role in I^2 integrin-dependent neutrophil migration by regulating Vav1 activity. ( 23325923 )
2013
50
Am80, a retinoic acid receptor agonist, ameliorates murine vasculitis through the suppression of neutrophil migration and activation. ( 23203767 )
2013

Variations for Neutrophil Migration

Expression for Neutrophil Migration

Search GEO for disease gene expression data for Neutrophil Migration.

Pathways for Neutrophil Migration

Pathways related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CD177 CXCL8 CXCR1 CXCR2 ICAM1 IRAK4
2
Show member pathways
13.78 CXCL8 CXCR1 CXCR2 IRAK4 ITGAM ITGB2
3
Show member pathways
13.53 CXCL8 ITGAM ITGB2 MAPK1 MAPK3 RAC1
4
Show member pathways
13.42 CXCL8 CXCR1 CXCR2 IRAK4 ITGAM ITGB2
5
Show member pathways
13.39 CXCL8 ICAM1 IRAK4 ITGAM ITGB2 MAPK1
6
Show member pathways
13.33 CD177 ITGAM ITGB2 MAPK1 MAPK3 RAC1
7
Show member pathways
13.29 CXCL8 CXCR1 CXCR2 MAPK1 MAPK3 MYH9
8
Show member pathways
13.14 CXCL8 CXCR1 CXCR2 ICAM1 ITGAM ITGB2
9
Show member pathways
13.1 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
10
Show member pathways
13.05 MAPK1 MAPK3 MYH9 RAC1 RAC2
11
Show member pathways
13.04 CXCL8 IRAK4 MAPK1 MAPK3 RAC1
12
Show member pathways
12.98 ITGAM ITGB2 MYH9 RAC1 RAC2
13
Show member pathways
12.93 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
14
Show member pathways
12.91 ITGAM MAPK1 MAPK3 RAC1 RAC2
15
Show member pathways
12.9 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
16
Show member pathways
12.88 ITGAM ITGB2 MAPK1 MAPK3 MYH9 RAC1
17 12.87 CXCL8 MAPK1 MAPK3 RAC1 RAC2
18
Show member pathways
12.86 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
19
Show member pathways
12.84 CXCL8 ICAM1 IRAK4 MAPK1 MAPK3
20
Show member pathways
12.84 CXCL8 ICAM1 ITGB2 MAPK1 MAPK3 RAC1
21
Show member pathways
12.83 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
22
Show member pathways
12.82 CXCL8 CXCR1 CXCR2 MAPK1 MAPK3 RAC1
23 12.81 IRAK4 MAPK1 MAPK3 RAC1 RAC2
24
Show member pathways
12.75 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
25
Show member pathways
12.69 ICAM1 ITGAM ITGB2 RAC1 RAC2
26
Show member pathways
12.63 MAPK1 MAPK3 MYH9 RAC1
27
Show member pathways
12.62 MAPK1 MAPK3 RAC1 RAC2
28
Show member pathways
12.61 CXCL8 ICAM1 MAPK1 MAPK3 RAC1
29 12.57 ITGB2 MYH9 RAC1 RAC2
30
Show member pathways
12.56 MAPK1 MAPK3 RAC1 RAC2
31
Show member pathways
12.51 CXCL8 CXCR1 CXCR2 RAC1
32 12.51 ITGAM ITGB2 MAPK1 MAPK3 MYH9 RAC1
33
Show member pathways
12.48 IRAK4 MAPK1 MAPK3 RAC1
34
Show member pathways
12.47 ICAM1 MAPK1 MAPK3 RAC1
35
Show member pathways
12.47 ITGAM ITGB2 MAPK1 MAPK3
36
Show member pathways
12.46 ICAM1 ITGB2 MAPK1 MAPK3 RAC1 RAC2
37
Show member pathways
12.45 IRAK4 MAPK1 MAPK3 RAC1
38
Show member pathways
12.45 ICAM1 MAPK1 MAPK3 RAC1
39
Show member pathways
12.44 MAPK1 MAPK3 RAC1 RAC2
40
Show member pathways
12.43 MAPK1 MAPK3 RAC1 RAC2
41
Show member pathways
12.38 MAPK1 MAPK3 RAC1 RAC2
42
Show member pathways
12.35 MAPK1 MAPK3 RAC1 RAC2
43
Show member pathways
12.35 MAPK1 MAPK3 MYH9 RAC1
44
Show member pathways
12.31 CXCL8 IRAK4 MAPK1 MAPK3
45
Show member pathways
12.28 MAPK1 MAPK3 RAC1 RAC2
46
Show member pathways
12.28 IRAK4 ITGAM ITGB2 MAPK1 MAPK3
47
Show member pathways
12.27 CXCL8 IRAK4 MAPK1 MAPK3
48 12.27 MAPK1 MAPK3 RAC1 RAC2
49
Show member pathways
12.25 CXCL8 CXCR1 CXCR2 MAPK1 MAPK3 RAC1
50 12.23 IRAK4 ITGAM ITGB2 MAPK1 MAPK3

GO Terms for Neutrophil Migration

Cellular components related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.73 CD177 ICAM1 ITGAM ITGB2
2 specific granule membrane GO:0035579 9.65 CD177 ITGAM ITGB2
3 tertiary granule membrane GO:0070821 9.63 CD177 ITGAM ITGB2
4 integrin complex GO:0008305 9.58 ITGAM ITGB2 MYH9
5 secretory granule membrane GO:0030667 9.56 CD177 CXCR1 CXCR2 RAC1
6 pseudopodium GO:0031143 9.49 MAPK1 MAPK3
7 plasma membrane GO:0005886 9.44 CD177 CXCR1 CXCR2 ICAM1 IRAK4 ITGAM
8 focal adhesion GO:0005925 9.43 ICAM1 MAPK1 MAPK3 MYH9 RAC1 RAC2
9 integrin alphaM-beta2 complex GO:0034688 9.37 ITGAM ITGB2
10 plasma membrane raft GO:0044853 9.33 CD177 ITGAM ITGB2
11 extracellular exosome GO:0070062 10.02 CD177 ICAM1 ITGAM ITGB2 MAPK1 MAPK3

Biological processes related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.98 CXCR1 CXCR2 MAPK1 MAPK3
2 response to lipopolysaccharide GO:0032496 9.92 CXCL8 ICAM1 MAPK1 MAPK3
3 cytokine-mediated signaling pathway GO:0019221 9.92 CXCL8 ICAM1 IRAK4 ITGAM ITGB2
4 neutrophil degranulation GO:0043312 9.91 CD177 CXCR1 CXCR2 ITGAM ITGB2 MAPK1
5 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 9.89 MAPK1 MAPK3 RAC1
6 cell-cell adhesion GO:0098609 9.88 ICAM1 ITGB2 MYH9
7 leukocyte migration GO:0050900 9.88 CD177 ICAM1 ITGAM ITGB2 MYH9
8 integrin-mediated signaling pathway GO:0007229 9.86 ITGAM ITGB2 MYH9
9 phagocytosis, engulfment GO:0006911 9.85 ITGAM ITGB2 MYH9
10 cellular response to tumor necrosis factor GO:0071356 9.84 CXCL8 ICAM1 MAPK1 MAPK3
11 chemokine-mediated signaling pathway GO:0070098 9.83 CXCL8 CXCR1 CXCR2
12 neutrophil chemotaxis GO:0030593 9.82 CXCL8 CXCR2 ITGB2
13 actin cytoskeleton reorganization GO:0031532 9.8 MYH9 RAC1 RAC2
14 platelet activation GO:0030168 9.8 MAPK1 MAPK3 RAC1 RAC2
15 positive regulation of actin filament polymerization GO:0030838 9.79 ICAM1 RAC1 RAC2
16 cellular response to organic substance GO:0071310 9.74 ICAM1 MAPK1 MAPK3
17 lung morphogenesis GO:0060425 9.71 MAPK1 MAPK3
18 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.71 MAPK1 MAPK3
19 positive regulation of lamellipodium assembly GO:0010592 9.71 RAC1 RAC2
20 face development GO:0060324 9.71 MAPK1 MAPK3
21 receptor internalization GO:0031623 9.71 CXCL8 CXCR1 CXCR2 ITGB2
22 dendritic cell chemotaxis GO:0002407 9.7 CXCR1 CXCR2
23 positive regulation of telomere capping GO:1904355 9.7 MAPK1 MAPK3
24 toll-like receptor 4 signaling pathway GO:0034142 9.7 ITGAM ITGB2
25 regulation of ossification GO:0030278 9.69 MAPK1 MAPK3
26 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.69 MAPK1 MAPK3
27 cellular response to dopamine GO:1903351 9.69 MAPK1 MAPK3
28 amyloid-beta clearance GO:0097242 9.68 ITGAM ITGB2
29 neutrophil activation GO:0042119 9.68 CXCL8 CXCR2
30 engulfment of apoptotic cell GO:0043652 9.67 RAC1 RAC2
31 regulation of stress-activated MAPK cascade GO:0032872 9.67 MAPK1 MAPK3
32 outer ear morphogenesis GO:0042473 9.66 MAPK1 MAPK3
33 acute inflammatory response to antigenic stimulus GO:0002438 9.65 CXCR2 ICAM1
34 Bergmann glial cell differentiation GO:0060020 9.65 MAPK1 MAPK3
35 regulation of early endosome to late endosome transport GO:2000641 9.64 MAPK1 MAPK3
36 trachea formation GO:0060440 9.63 MAPK1 MAPK3
37 positive regulation of superoxide anion generation GO:0032930 9.63 CD177 ITGAM ITGB2
38 positive regulation of neutrophil chemotaxis GO:0090023 9.62 CXCL8 CXCR2 RAC1 RAC2
39 regulation of hydrogen peroxide metabolic process GO:0010310 9.61 RAC1 RAC2
40 caveolin-mediated endocytosis GO:0072584 9.61 MAPK1 MAPK3
41 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.61 CD177 ITGAM ITGB2
42 regulation of cellular pH GO:0030641 9.6 MAPK1 MAPK3
43 regulation of Golgi inheritance GO:0090170 9.59 MAPK1 MAPK3
44 regulation of respiratory burst GO:0060263 9.58 RAC1 RAC2
45 response to epidermal growth factor GO:0070849 9.58 MAPK1 MAPK3
46 cardiac neural crest cell development involved in heart development GO:0061308 9.56 MAPK1 MAPK3
47 interleukin-8-mediated signaling pathway GO:0038112 9.51 CXCR1 CXCR2
48 leukocyte cell-cell adhesion GO:0007159 9.46 CD177 ICAM1 ITGB2 UMOD
49 positive regulation of neutrophil degranulation GO:0043315 9.43 CD177 ITGAM ITGB2
50 chemotaxis GO:0006935 9.43 CXCL8 CXCR1 CXCR2 MAPK1 RAC1 RAC2

Molecular functions related to Neutrophil Migration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase activity GO:0004708 9.37 MAPK1 MAPK3
2 MAP kinase activity GO:0004707 9.32 MAPK1 MAPK3
3 C-X-C chemokine receptor activity GO:0016494 9.26 CXCR1 CXCR2
4 complement component C3b binding GO:0001851 9.16 ITGAM ITGB2
5 interleukin-8 binding GO:0019959 8.96 CXCR1 CXCR2
6 interleukin-8 receptor activity GO:0004918 8.62 CXCR1 CXCR2

Sources for Neutrophil Migration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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