Aliases & Classifications for Neutrophil Migration

MalaCards integrated aliases for Neutrophil Migration:

Name: Neutrophil Migration 58
Neutrophil Chemotactic Response, Abnormal 58
Neutrophil Chemotactic Response; Ncr 58
Neutrophil Chemotactic Response 58
Ncr 58
Nm 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
neutrophil migration:
Inheritance autosomal dominant inheritance


Summaries for Neutrophil Migration

MalaCards based summary : Neutrophil Migration, also known as neutrophil chemotactic response, abnormal, is related to peritonitis and pertussis. An important gene associated with Neutrophil Migration is NM (Neutrophil Migration), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tofacitinib and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and endothelial, and related phenotypes are immunodeficiency and asthma

Description from OMIM: 162820

Related Diseases for Neutrophil Migration

Diseases related to Neutrophil Migration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 peritonitis 30.0 CXCL8 ICAM1 ITGAM
2 pertussis 29.9 ITGAM ITGB2 MAPK1
3 pulmonary disease, chronic obstructive 29.8 CXCL8 CXCR1 CXCR2
4 bacterial infectious disease 29.6 CXCL8 IRAK4 ITGAM
5 arthritis 10.3
6 annular erythema 10.2 ICAM1 ITGB2
7 toxicodendron dermatitis 10.1 CXCL8 ICAM1
8 denture stomatitis 10.1 CXCL8 CXCR1
9 herpes simplex virus keratitis 10.1 CXCL8 ICAM1
10 acute pyelonephritis 10.1 CXCL8 CXCR1 CXCR2
11 acute respiratory distress syndrome 10.1
12 pneumonia 10.1
13 mooren's ulcer 10.1 ICAM1 ITGB2
14 lymphocytic vasculitis 10.0 ICAM1 ITGAM
15 hepatocellular carcinoma 10.0
16 leukemia, acute myeloid 10.0
17 cervical cancer 10.0
18 noonan syndrome 3 10.0
19 gastric cancer 10.0
20 hematopoietic stem cell transplantation 10.0
21 japanese encephalitis 10.0
22 orchitis 10.0
23 myeloid leukemia 10.0
24 encephalitis 10.0
25 rheumatoid arthritis 10.0
26 cystic fibrosis 10.0
27 bacteriuria 10.0 CXCL8 CXCR1 CXCR2 UMOD
28 pyelonephritis 10.0 CXCL8 CXCR1 CXCR2 UMOD
29 leukocyte adhesion deficiency, type i 9.9 ICAM1 ITGAM ITGB2
30 shwartzman phenomenon 9.9 ICAM1 ITGAM
31 colitis 9.9
32 ischemia 9.9
33 hyper-ige recurrent infection syndrome 1, autosomal dominant 9.9
34 lepromatous leprosy 9.9
35 onchocerciasis 9.9
36 asthma 9.8
37 granuloma annulare 9.8
38 periodontitis 9.8
39 hypoxia 9.8
40 autoimmune glomerulonephritis 9.8 ICAM1 ITGB2
41 behcet syndrome 9.7
42 breast cancer 9.7
43 otitis media 9.7
44 pulmonary fibrosis, idiopathic 9.7
45 triiodothyronine receptor auxiliary protein 9.7
46 stroke, ischemic 9.7
47 myelodysplastic syndrome 9.7
48 alcoholic hepatitis 9.7
49 brain injury 9.7
50 burns 9.7

Graphical network of the top 20 diseases related to Neutrophil Migration:



Diseases related to Neutrophil Migration

Symptoms & Phenotypes for Neutrophil Migration

Human phenotypes related to Neutrophil Migration:

33 (show all 8)
# Description HPO Frequency HPO Source Accession
1 immunodeficiency 33 HP:0002721
2 asthma 33 HP:0002099
3 eczema 33 HP:0000964
4 recurrent bacterial infections 33 HP:0002718
5 recurrent skin infections 33 HP:0001581
6 recurrent fungal infections 33 HP:0002841
7 congenital ichthyosiform erythroderma 33 HP:0007431
8 abnormal leukocyte morphology 33 HP:0001881

Symptoms via clinical synopsis from OMIM:

58
Immune:
immunodeficiency

Skin:
congenital ichthyosis

Clinical features from OMIM:

162820

GenomeRNAi Phenotypes related to Neutrophil Migration according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.35 IRAK4 MAPK3 MYH9 RAC1 RAC2
2 Decreased telomerase activity GR00156-A 8.8 MAPK1 MAPK3 RAC1

MGI Mouse Phenotypes related to Neutrophil Migration:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 CXCR2 ICAM1 IRAK4 ITGAM ITGB2 MAPK1
2 hematopoietic system MP:0005397 9.93 CD177 CXCR1 CXCR2 ICAM1 IRAK4 ITGAM
3 cardiovascular system MP:0005385 9.92 CXCR2 ICAM1 ITGB2 MAPK1 MAPK3 MYH9
4 homeostasis/metabolism MP:0005376 9.7 CXCR2 ICAM1 IRAK4 ITGAM ITGB2 MAPK1
5 immune system MP:0005387 9.44 CD177 CXCR1 CXCR2 ICAM1 IRAK4 ITGAM

Drugs & Therapeutics for Neutrophil Migration

Drugs for Neutrophil Migration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tofacitinib Approved, Investigational Phase 2 477600-75-2
2
Azithromycin Approved Phase 2 83905-01-5 447043 55185
3
Fluticasone Approved, Experimental Phase 2 90566-53-3 62924
4 Protein Kinase Inhibitors Phase 2
5 Anti-Inflammatory Agents Phase 2,Not Applicable
6 Peripheral Nervous System Agents Phase 2,Not Applicable
7 Anti-Infective Agents Phase 2,Not Applicable
8 Cholinergic Antagonists Phase 2
9 Dermatologic Agents Phase 2
10 Respiratory System Agents Phase 2
11 Anti-Asthmatic Agents Phase 2
12 Anti-Allergic Agents Phase 2
13 Bronchodilator Agents Phase 2
14 Anti-Bacterial Agents Phase 2
15 Antibiotics, Antitubercular Phase 2
16 Autonomic Agents Phase 2
17
Simvastatin Approved Not Applicable 79902-63-9 54454
18
Pioglitazone Approved, Investigational Not Applicable 111025-46-8 4829
19
Ibuprofen Approved Not Applicable 15687-27-1 3672
20
Ethanol Approved Not Applicable 64-17-5 702
21
tannic acid Approved Not Applicable 1401-55-4
22
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
23
Caffeine Approved Not Applicable 58-08-2 2519
24
Sulforaphane Investigational Not Applicable 4478-93-7, 142825-10-3 5350
25 Analgesics Not Applicable
26 Antirheumatic Agents Not Applicable
27 Hydroxymethylglutaryl-CoA Reductase Inhibitors Not Applicable
28 Antimetabolites Not Applicable
29 Lipid Regulating Agents Not Applicable
30 Anticholesteremic Agents Not Applicable
31 Hypoglycemic Agents Not Applicable
32 Hypolipidemic Agents Not Applicable
33 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
34 Cyclooxygenase Inhibitors Not Applicable
35 Analgesics, Non-Narcotic Not Applicable
36 Protective Agents Not Applicable
37 Sulforafan Not Applicable
38 Phosphodiesterase Inhibitors Not Applicable
39 Central Nervous System Stimulants Not Applicable
40 Neurotransmitter Agents Not Applicable
41 Anti-Infective Agents, Local Not Applicable
42 Central Nervous System Depressants Not Applicable
43 Purinergic P1 Receptor Antagonists Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 The Safety And Efficacy Of Maintenance Therapy With CP-690,550 Completed NCT01393899 Phase 2 Placebo;CP-690,550;CP-690,550
2 A Study To Investigate Safety And Efficacy Of CP-690,550 For Induction Therapy In Subjects With Moderate To Severe Crohn's Disease Completed NCT01393626 Phase 2 Placebo;CP-690,550;CP-690,550
3 A Study To Investigate The Safety And Efficacy Of CP- 690,550 In Patients With Moderate And Severe Ulcerative Colitis. Completed NCT00787202 Phase 2 CP- 690 550;CP- 690 550;CP- 690 550;CP- 690 550
4 A Open-Label Study Of CP-690,550 As Long-Term Therapy (48 Weeks) In Subjects With Crohn's Disease Completed NCT01470599 Phase 2 CP-690,550;CP-690,550
5 A Study To Investigate The Safety And Possible Clinical Benefit Of Multistem(r) In Patients With Moderate To Severe Ulcerative Colitis Completed NCT01240915 Phase 2 placebo;MultiStem low dose;placebo;MultiStem low dose;placebo;MultiStem high dose;placebo;MultiStem high dose;placebo;MultiStem high dose;placebo;MultiStem high dose
6 Long-Term Study of the Effects of Navarixin (SCH 527123, MK-7123) in Participants With Moderate to Severe COPD (MK-7123-019) Terminated NCT01006616 Phase 2 Navarixin;Placebo;Rescue medication
7 Bronchiectasis in Chronic Obstructive Pulmonary Disease (COPD) Patients: Role of Prophylaxis Terminated NCT00524095 Phase 2 azithromycin and fluticasone;fluticasone and azithromycin
8 Study of SCH 527123 in Subjects With Severe Asthma (Study P05109AM1) Withdrawn NCT01006161 Phase 2 SCH 527123;SCH 527123;SCH 527123;SCH 527123
9 Pilot Mouthwash Study of Pioglitazone and Simvastatin in Healthy Volunteers Completed NCT00531882 Not Applicable Pioglitazone;Simvastatin;Ibuprofen
10 Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation Completed NCT01315665 Not Applicable
11 Assessment of the Predictive Value of Fecal Calprotectin for the Outcome of Severe Alcoholic Hepatitis Completed NCT02808663 Not Applicable
12 Leukocyte Function in Asthma and COPD Completed NCT00147069
13 Influence of Lifestyle Factors on Neutrophil Migration Pilot Study Recruiting NCT02411318 Not Applicable ProLab 200mg caffeine capsule
14 Resistin in Septic Shock and Acute Kidney Injury Recruiting NCT03146546
15 Microfluidic Assessment of Clinical Outcomes in Preterm Newborns Recruiting NCT03291496
16 Effects of Resistin on Neutrophil Function Withdrawn NCT03626870

Search NIH Clinical Center for Neutrophil Migration

Genetic Tests for Neutrophil Migration

Anatomical Context for Neutrophil Migration

MalaCards organs/tissues related to Neutrophil Migration:

42
Neutrophil, Skin, Endothelial, Prostate, Bone, Brain, Liver

Publications for Neutrophil Migration

Articles related to Neutrophil Migration:

(show top 50) (show all 3607)
# Title Authors Year
1
A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia. ( 30982177 )
2019
2
Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels in brain of depression model mice: A study of three different doses of 810 nm laser. ( 30883832 )
2019
3
Outcomes of long-pulsed 1064 nm Nd:YAG laser treatment of basal cell carcinoma: A retrospective review. ( 30508262 )
2019
4
A pilot prospective study of 577-nm yellow subthreshold micropulse laser treatment with two different power settings for acute central serous chorioretinopathy. ( 30710172 )
2019
5
Selective ablation of dental caries using coaxial Co2 (9.3-μm) and near-IR (1880-nm) lasers. ( 30024032 )
2019
6
Successful use of a fractional 2940-nm laser in treating chronic, severe erosive pustular dermatosis of the scalp. ( 30740503 )
2019
7
Synthesis and biological evaluation of 2.4 nm thiolate-protected gold nanoparticles conjugated to Cetuximab for targeting glioblastoma cancer cells via the EGFR. ( 30650397 )
2019
8
Efficacy of 308-nm Monochromatic Excimer Light in the Management of Halo Nevi: An Open-Label, Pilot Study. ( 31057264 )
2019
9
Effect of photodynamic therapy by 810 and 940 nm diode laser on Herpes Simplex Virus 1: An in vitro study. ( 30447412 )
2019
10
Successful treatment of inflammatory linear verrucous epidermal nevus (ILVEN) with 308-nm excimer laser: patient patient required. ( 30648292 )
2019
11
The 1470 nm diode laser with an intralesional fiber device: a proposed solution for the treatment of inflamed and infected keloids. ( 30783604 )
2019
12
Successful Treatment of Keratosis Follicularis Spinulosa Decalvans With an 800-nm Diode Laser. ( 30893172 )
2019
13
Utilizing 808 nm laser for sensitizing of melanoma tumors to megavoltage radiation therapy. ( 31076924 )
2019
14
Desmoplastic Melanoma Arising after 1,064 nm q-Switched Nd:YAG Laser of a Suspected Solar Lentigo. ( 31080677 )
2019
15
Efficacy of a phenol derivative, isopropyl vanillate, as an anti-inflammatory agent: A new small molecule inhibitor of COX and neutrophil migration. ( 31112325 )
2019
16
Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation. ( 30696624 )
2019
17
Inhibition of neutrophil migration and reduction of oxidative stress by ethyl p-coumarate in acute and chronic inflammatory models. ( 30668327 )
2019
18
LL-37 and its analog FF/CAP18 attenuate neutrophil migration in sepsis-induced acute lung injury. ( 30537236 )
2019
19
Direct Inhibitory Effect of the PDE4 Inhibitor Roflumilast on Neutrophil Migration in Chronic Obstructive Pulmonary Disease. ( 30395484 )
2019
20
Molluscum Contagiosum Infection After 1927-nm Nonablative Fractional Laser Treatment. ( 30856635 )
2019
21
Inhibition effects of Yuxiao San combined with cisplatin on transplanted tumor growths via upregulation of nm-23 and downregulation of K-ras in Lewis lung cancer mice. ( 30655894 )
2019
22
Clinical Outcome of 1064-nm Picosecond Neodymium-Doped Yttrium Aluminium Garnet Laser for the Treatment of Hypertrophic Scars. ( 29757022 )
2019
23
Short-duration multiple-session subthreshold micropulse yellow laser (577 nm) for chronic central serous chorioretinopathy: results at 3 years. ( 30610228 )
2019
24
Treating Hypertrophic Burn Scar With 2940-nm Er:YAG Laser Fractional Ablation Improves Scar Characteristics as Measured by Noninvasive Technology. ( 31046088 )
2019
25
Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice. ( 30971272 )
2019
26
The study of killing effect and inducing apoptosis of 630-nm laser on lung adenocarcinoma A549 cells mediated by hematoporphyrin derivatives in vitro. ( 31049741 )
2019
27
Efficacy and safety of 308-nm excimer lamp in the treatment of scalp psoriasis: a retrospective study. ( 30648290 )
2019
28
Treatment of erythematotelangiectatic rosacea, facial erythema, and facial telangiectasia with a 577-nm pro-yellow laser: a case series. ( 30097757 )
2019
29
Treatment of Moderate-to-severe Facial Acne Vulgaris with Solid-state Fractional 589/1,319-nm Laser. ( 30988870 )
2019
30
A Novel Combined Light-Based Treatment of Acne Vulgaris With 1,450-nm Diode Laser and 450-nm Blue Light. ( 30789515 )
2019
31
Noninvasive Atrophic Acne Scar Treatment in Asians With a 755-nm Picosecond Laser Using A Diffractive Optic Lens-A Retrospective Photographic Review. ( 30234649 )
2019
32
Sub-5 nm Ultra-Fine FeP Nanodots as Efficient Co-Catalysts Modified Porous g-C3N4 for Precious-Metal-Free Photocatalytic Hydrogen Evolution under Visible Light. ( 30615433 )
2019
33
Initial metal-metal bond breakage detected by fs X-ray scattering in the photolysis of Ru3(CO)12 in cyclohexane at 400 nm. ( 30628601 )
2019
34
Initial Protein Unfolding Events in Ubiquitin, Cytochrome c and Myoglobin Are Revealed with the Use of 213 nm UVPD Coupled to IM-MS. ( 29949061 )
2019
35
Efficacy and safety of long pulse 1064 and 2940 nm lasers in non-invasive lipolysis and skin tightening. ( 31008550 )
2019
36
A prospective randomized comparative study on 60 Indian patients of melasma, comparing pixel Q-switched NdYAG (1064 nm), super skin rejuvenation (540 nm) and ablative pixel erbium YAG (2940 nm) lasers, with a review of the literature. ( 31010346 )
2019
37
Site-Specific and Coherent Manipulation of Individual Qubits in a 1D Optical Lattice with a 532-nm Site Separation. ( 31012628 )
2019
38
Thulium doped LaF3 for nanothermometry operating over 1000 nm. ( 31012902 )
2019
39
Impact of charge state on 193 nm ultraviolet photodissociation of protein complexes. ( 31016301 )
2019
40
Room-temperature, atmospheric-pressure microsputtering of dense, electrically conductive, sub-100 nm gold films. ( 31017876 )
2019
41
Sub-10 nm Ag Nanoparticles/Graphene Oxide: Controllable Synthesis, Size-Dependent and Extremely Ultrahigh Catalytic Activity. ( 31025541 )
2019
42
Influence of electrical signals on pea leaf reflectance in the 400-800-nm range. ( 31025577 )
2019
43
Localization of Cyclopropane Modifications in Bacterial Lipids via 213 nm Ultraviolet Photodissociation Mass Spectrometry. ( 31026154 )
2019
44
Device Optimization of Nano-Plate Transistors for 3.5 nm Technology Node. ( 31027027 )
2019
45
Effect of 222-nm krypton-chloride excilamp treatment on inactivation of Escherichia coli O157:H7 and Salmonella Typhimurium on alfalfa seeds and seed germination. ( 31027771 )
2019
46
1064 nm Nd:YAG laser light affect transmembrane mitochondria respiratory chain complexes. ( 31033186 )
2019
47
Successful treatment of facial vascular skin diseases with a 577-nm pro-yellow laser. ( 31033204 )
2019
48
Click chemistry on the surface of ultrasmall gold nanoparticles (2 nm) for covalent ligand attachment followed by NMR spectroscopy. ( 31039607 )
2019
49
915  nm all-fiber laser based on novel Nd-doped high alumina and yttria glass @ silica glass hybrid fiber for the pure blue fiber laser. ( 31042171 )
2019
50
Influence of air humidity on 248-nm ultraviolet laser pulse filamentation. ( 31042174 )
2019

Variations for Neutrophil Migration

Expression for Neutrophil Migration

Search GEO for disease gene expression data for Neutrophil Migration.

Pathways for Neutrophil Migration

Pathways related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CD177 CXCL8 CXCR1 CXCR2 ICAM1 IRAK4
2
Show member pathways
13.8 CXCL8 CXCR1 CXCR2 IRAK4 ITGAM ITGB2
3
Show member pathways
13.56 CXCL8 ICAM1 ITGAM ITGB2 MAPK1 MAPK3
4
Show member pathways
13.44 CXCL8 CXCR1 CXCR2 IRAK4 ITGAM ITGB2
5
Show member pathways
13.4 CXCL8 ICAM1 IRAK4 ITGAM ITGB2 MAPK1
6
Show member pathways
13.35 CD177 ITGAM ITGB2 MAPK1 MAPK3 RAC1
7
Show member pathways
13.31 CXCL8 CXCR1 CXCR2 MAPK1 MAPK3 MYH9
8
Show member pathways
13.2 CXCL8 CXCR1 CXCR2 ICAM1 ITGAM ITGB2
9
Show member pathways
13.12 CXCL8 IRAK4 MAPK1 MAPK3 RAC1
10
Show member pathways
13.11 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
11
Show member pathways
13.05 MAPK1 MAPK3 MYH9 RAC1 RAC2
12
Show member pathways
13.02 ITGAM ITGB2 MYH9 RAC1 RAC2
13
Show member pathways
12.94 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
14
Show member pathways
12.91 ITGAM MAPK1 MAPK3 RAC1 RAC2
15
Show member pathways
12.91 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
16
Show member pathways
12.91 ITGAM ITGB2 MAPK1 MAPK3 MYH9 RAC1
17
Show member pathways
12.89 CXCL8 CXCR2 ICAM1 IRAK4 MAPK1 MAPK3
18 12.88 CXCL8 MAPK1 MAPK3 RAC1 RAC2
19
Show member pathways
12.87 CXCL8 ICAM1 ITGB2 MAPK1 MAPK3 RAC1
20
Show member pathways
12.86 CXCL8 CXCR1 CXCR2 MAPK1 MAPK3 RAC1
21
Show member pathways
12.85 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
22
Show member pathways
12.85 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
23 12.82 IRAK4 MAPK1 MAPK3 RAC1 RAC2
24
Show member pathways
12.77 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
25
Show member pathways
12.7 ICAM1 ITGAM ITGB2 RAC1 RAC2
26
Show member pathways
12.64 MAPK1 MAPK3 MYH9 RAC1
27
Show member pathways
12.62 MAPK1 MAPK3 RAC1 RAC2
28 12.57 ITGB2 MYH9 RAC1 RAC2
29
Show member pathways
12.56 MAPK1 MAPK3 RAC1 RAC2
30 12.54 ITGAM ITGB2 MAPK1 MAPK3 MYH9 RAC1
31
Show member pathways
12.52 CXCL8 CXCR1 CXCR2 RAC1
32
Show member pathways
12.49 IRAK4 MAPK1 MAPK3 RAC1
33
Show member pathways
12.49 ICAM1 ITGB2 MAPK1 MAPK3 RAC1 RAC2
34
Show member pathways
12.47 ICAM1 MAPK1 MAPK3 RAC1
35
Show member pathways
12.47 ITGAM ITGB2 MAPK1 MAPK3
36
Show member pathways
12.46 IRAK4 MAPK1 MAPK3 RAC1
37
Show member pathways
12.45 ICAM1 MAPK1 MAPK3 RAC1
38
Show member pathways
12.45 MAPK1 MAPK3 RAC1 RAC2
39
Show member pathways
12.44 ITGAM ITGB2 MAPK1 MAPK3 RAC1 RAC2
40
Show member pathways
12.43 MAPK1 MAPK3 RAC1 RAC2
41
Show member pathways
12.39 MAPK1 MAPK3 RAC1 RAC2
42 12.38 MAPK1 MAPK3 RAC1 RAC2
43
Show member pathways
12.37 CXCL8 IRAK4 MAPK1 MAPK3 RAC1
44
Show member pathways
12.36 MAPK1 MAPK3 MYH9 RAC1
45
Show member pathways
12.3 CXCL8 CXCR1 CXCR2 MAPK1 MAPK3 RAC1
46 12.29 MAPK1 MAPK3 RAC1 RAC2
47
Show member pathways
12.29 MAPK1 MAPK3 RAC1 RAC2
48
Show member pathways
12.29 IRAK4 ITGAM ITGB2 MAPK1 MAPK3
49
Show member pathways
12.28 CXCL8 IRAK4 MAPK1 MAPK3
50 12.26 IRAK4 ITGAM ITGB2 MAPK1 MAPK3

GO Terms for Neutrophil Migration

Cellular components related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.77 CXCR1 CXCR2 ICAM1 ITGAM ITGB2
2 plasma membrane GO:0005886 9.77 CD177 CXCR1 CXCR2 ICAM1 IRAK4 ITGAM
3 membrane raft GO:0045121 9.71 CD177 ICAM1 ITGAM ITGB2
4 specific granule membrane GO:0035579 9.65 CD177 ITGAM ITGB2
5 tertiary granule membrane GO:0070821 9.63 CD177 ITGAM ITGB2
6 pseudopodium GO:0031143 9.49 MAPK1 MAPK3
7 secretory granule membrane GO:0030667 9.46 CD177 CXCR1 CXCR2 RAC1
8 plasma membrane raft GO:0044853 9.43 CD177 ITGAM ITGB2
9 integrin alphaM-beta2 complex GO:0034688 9.32 ITGAM ITGB2
10 focal adhesion GO:0005925 9.17 ICAM1 ITGB2 MAPK1 MAPK3 MYH9 RAC1
11 extracellular exosome GO:0070062 10.03 CD177 ICAM1 ITGAM ITGB2 MYH9 RAC1

Biological processes related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.91 CXCL8 ICAM1 IRAK4 ITGAM ITGB2
2 neutrophil degranulation GO:0043312 9.91 CD177 CXCR1 CXCR2 ITGAM ITGB2 MAPK1
3 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 9.89 MAPK1 MAPK3 RAC1
4 Fc-epsilon receptor signaling pathway GO:0038095 9.87 MAPK1 MAPK3 RAC1
5 phagocytosis, engulfment GO:0006911 9.86 ITGAM ITGB2 MYH9
6 integrin-mediated signaling pathway GO:0007229 9.85 ITGAM ITGB2 MYH9
7 cellular response to tumor necrosis factor GO:0071356 9.85 CXCL8 ICAM1 MAPK1 MAPK3
8 leukocyte migration GO:0050900 9.85 CD177 ICAM1 ITGAM ITGB2 MYH9
9 calcium-mediated signaling GO:0019722 9.84 CXCL8 CXCR1 CXCR2
10 chemokine-mediated signaling pathway GO:0070098 9.82 CXCL8 CXCR1 CXCR2
11 neutrophil chemotaxis GO:0030593 9.8 CXCL8 CXCR1 CXCR2 ITGB2
12 cellular response to organic substance GO:0071310 9.75 ICAM1 MAPK1 MAPK3
13 lung morphogenesis GO:0060425 9.71 MAPK1 MAPK3
14 Rac protein signal transduction GO:0016601 9.71 RAC1 RAC2
15 cell projection assembly GO:0030031 9.71 RAC1 RAC2
16 positive regulation of lamellipodium assembly GO:0010592 9.71 RAC1 RAC2
17 receptor internalization GO:0031623 9.71 CXCL8 CXCR1 CXCR2 ITGB2
18 microglial cell activation GO:0001774 9.7 ITGAM ITGB2
19 face development GO:0060324 9.7 MAPK1 MAPK3
20 dendritic cell chemotaxis GO:0002407 9.69 CXCR1 CXCR2
21 positive regulation of telomere capping GO:1904355 9.69 MAPK1 MAPK3
22 toll-like receptor 4 signaling pathway GO:0034142 9.69 ITGAM ITGB2
23 cellular response to dopamine GO:1903351 9.68 MAPK1 MAPK3
24 regulation of ossification GO:0030278 9.68 MAPK1 MAPK3
25 amyloid-beta clearance GO:0097242 9.68 ITGAM ITGB2
26 neutrophil activation GO:0042119 9.67 CXCL8 CXCR2
27 outer ear morphogenesis GO:0042473 9.66 MAPK1 MAPK3
28 positive regulation of microglial cell activation GO:1903980 9.66 ITGAM ITGB2
29 regulation of stress-activated MAPK cascade GO:0032872 9.65 MAPK1 MAPK3
30 acute inflammatory response to antigenic stimulus GO:0002438 9.65 CXCR2 ICAM1
31 Bergmann glial cell differentiation GO:0060020 9.65 MAPK1 MAPK3
32 positive regulation of superoxide anion generation GO:0032930 9.65 CD177 ITGAM ITGB2
33 regulation of early endosome to late endosome transport GO:2000641 9.64 MAPK1 MAPK3
34 trachea formation GO:0060440 9.63 MAPK1 MAPK3
35 caveolin-mediated endocytosis GO:0072584 9.62 MAPK1 MAPK3
36 regulation of cellular pH GO:0030641 9.62 MAPK1 MAPK3
37 leukocyte cell-cell adhesion GO:0007159 9.62 CD177 ICAM1 ITGB2 UMOD
38 regulation of hydrogen peroxide metabolic process GO:0010310 9.61 RAC1 RAC2
39 negative regulation of dopamine metabolic process GO:0045963 9.61 ITGAM ITGB2
40 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.61 CD177 ITGAM ITGB2
41 regulation of Golgi inheritance GO:0090170 9.6 MAPK1 MAPK3
42 regulation of respiratory burst GO:0060263 9.59 RAC1 RAC2
43 response to epidermal growth factor GO:0070849 9.58 MAPK1 MAPK3
44 cardiac neural crest cell development involved in heart development GO:0061308 9.57 MAPK1 MAPK3
45 positive regulation of prostaglandin-E synthase activity GO:2000363 9.56 ITGAM ITGB2
46 interleukin-8-mediated signaling pathway GO:0038112 9.52 CXCR1 CXCR2
47 positive regulation of neutrophil chemotaxis GO:0090023 9.46 CXCL8 CXCR2 RAC1 RAC2
48 positive regulation of neutrophil degranulation GO:0043315 9.43 CD177 ITGAM ITGB2
49 chemotaxis GO:0006935 9.43 CXCL8 CXCR1 CXCR2 MAPK1 RAC1 RAC2
50 neutrophil migration GO:1990266 8.92 CD177 IRAK4 ITGB2 UMOD

Molecular functions related to Neutrophil Migration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase activity GO:0004708 9.4 MAPK1 MAPK3
2 MAP kinase activity GO:0004707 9.37 MAPK1 MAPK3
3 C-X-C chemokine receptor activity GO:0016494 9.32 CXCR1 CXCR2
4 complement component C3b binding GO:0001851 9.26 ITGAM ITGB2
5 integrin binding GO:0005178 9.26 CD177 ICAM1 ITGB2 MYH9
6 interleukin-8 binding GO:0019959 9.16 CXCR1 CXCR2
7 interleukin-8 receptor activity GO:0004918 8.62 CXCR1 CXCR2

Sources for Neutrophil Migration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
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