Aliases & Classifications for Neutrophil Migration

MalaCards integrated aliases for Neutrophil Migration:

Name: Neutrophil Migration 57
Neutrophil Chemotactic Response, Abnormal 57
Neutrophil Chemotactic Response; Ncr 57
Neutrophil Chemotactic Response 57
Ncr 57
Nm 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
neutrophil migration:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 57 162820
MedGen 42 C0312860

Summaries for Neutrophil Migration

MalaCards based summary : Neutrophil Migration, also known as neutrophil chemotactic response, abnormal, is related to peritonitis and pertussis. An important gene associated with Neutrophil Migration is NM (Neutrophil Migration), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Etanercept and Nedaplatin have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, lung and endothelial, and related phenotypes are immunodeficiency and asthma

More information from OMIM: 162820

Related Diseases for Neutrophil Migration

Diseases related to Neutrophil Migration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 peritonitis 30.5 ITGAM ICAM1 CXCL8
2 pertussis 30.2 MAPK1 ITGB2 ITGAM
3 pulmonary disease, chronic obstructive 29.8 CXCR2 CXCR1 CXCL8
4 bacterial infectious disease 29.8 ITGAM IRAK4 CXCL8
5 pyelonephritis 29.5 UMOD CXCR2 CXCR1 CXCL8
6 acute respiratory distress syndrome 10.3
7 annular erythema 10.3 ITGB2 ICAM1
8 toxicodendron dermatitis 10.3 ICAM1 CXCL8
9 herpes simplex virus keratitis 10.3 ICAM1 CXCL8
10 hepatitis c virus 10.2
11 acute pyelonephritis 10.2 CXCR2 CXCR1 CXCL8
12 severe combined immunodeficiency 10.2
13 denture stomatitis 10.2 CXCR1 CXCL8
14 mooren's ulcer 10.2 ITGB2 ICAM1
15 proteasome-associated autoinflammatory syndrome 1 10.1
16 hepatitis c 10.1
17 fibrosarcoma 10.1
18 mouth disease 10.1
19 lymphocytic vasculitis 10.1 ITGAM ICAM1
20 lung disease 10.1
21 inflammatory bowel disease 10.0
22 ulcerative colitis 10.0
23 cytokine deficiency 10.0
24 cystic fibrosis 10.0
25 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
26 acute cystitis 10.0
27 periodontitis 10.0
28 vasculitis 10.0
29 crohn's disease 10.0
30 shwartzman phenomenon 10.0 ITGAM ICAM1
31 bacteriuria 10.0 UMOD CXCR2 CXCR1 CXCL8
32 leukocyte adhesion deficiency, type i 9.9 ITGB2 ITGAM ICAM1
33 colorectal cancer 9.9
34 hepatic adenomas, familial 9.9
35 hypertension, essential 9.9
36 down syndrome 9.9
37 lung cancer 9.9
38 neuroblastoma 1 9.9
39 body mass index quantitative trait locus 11 9.9
40 leukemia, acute myeloid 9.9
41 body mass index quantitative trait locus 9 9.9
42 body mass index quantitative trait locus 8 9.9
43 cervical cancer 9.9
44 paragangliomas 3 9.9
45 body mass index quantitative trait locus 4 9.9
46 body mass index quantitative trait locus 10 9.9
47 body mass index quantitative trait locus 7 9.9
48 diabetes mellitus, ketosis-prone 9.9
49 body mass index quantitative trait locus 12 9.9
50 body mass index quantitative trait locus 14 9.9

Graphical network of the top 20 diseases related to Neutrophil Migration:



Diseases related to Neutrophil Migration

Symptoms & Phenotypes for Neutrophil Migration

Human phenotypes related to Neutrophil Migration:

32 (show all 8)
# Description HPO Frequency HPO Source Accession
1 immunodeficiency 32 HP:0002721
2 asthma 32 HP:0002099
3 eczema 32 HP:0000964
4 recurrent bacterial infections 32 HP:0002718
5 recurrent skin infections 32 HP:0001581
6 recurrent fungal infections 32 HP:0002841
7 congenital ichthyosiform erythroderma 32 HP:0007431
8 abnormal leukocyte morphology 32 HP:0001881

Symptoms via clinical synopsis from OMIM:

57
Immune:
immunodeficiency

Skin:
congenital ichthyosis

Clinical features from OMIM:

162820

GenomeRNAi Phenotypes related to Neutrophil Migration according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.35 IRAK4 MAPK3 MYH9 RAC1 RAC2
2 Decreased telomerase activity GR00156-A 8.8 MAPK1 MAPK3 RAC1

MGI Mouse Phenotypes related to Neutrophil Migration:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 CXCR2 ICAM1 IRAK4 ITGAM ITGB2 MAPK1
2 hematopoietic system MP:0005397 9.93 CD177 CXCR1 CXCR2 ICAM1 IRAK4 ITGAM
3 cardiovascular system MP:0005385 9.92 CXCR2 ICAM1 ITGB2 MAPK1 MAPK3 MYH9
4 homeostasis/metabolism MP:0005376 9.7 CXCR2 ICAM1 IRAK4 ITGAM ITGB2 MAPK1
5 immune system MP:0005387 9.44 CD177 CXCR1 CXCR2 ICAM1 IRAK4 ITGAM

Drugs & Therapeutics for Neutrophil Migration

Drugs for Neutrophil Migration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 3 185243-69-0
2
Nedaplatin Approved, Investigational Phase 2, Phase 3 95734-82-0
3
Fluorouracil Approved Phase 2, Phase 3 51-21-8 3385
4 Analgesics Phase 3
5 Analgesics, Non-Narcotic Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 3
7 Antirheumatic Agents Phase 3
8 Gastrointestinal Agents Phase 3
9 Immunosuppressive Agents Phase 3
10 Immunologic Factors Phase 3
11
Fluticasone Approved, Experimental Phase 2 90566-53-3 62924
12
Azithromycin Approved Phase 2 83905-01-5 447043 55185
13 Anti-Infective Agents Phase 2
14 Cholinergic Antagonists Phase 2
15 Peripheral Nervous System Agents Phase 2
16 Anti-Inflammatory Agents Phase 2
17 Anti-Bacterial Agents Phase 2
18 Anti-Allergic Agents Phase 2
19 Antibiotics, Antitubercular Phase 2
20 Respiratory System Agents Phase 2
21 Dermatologic Agents Phase 2
22 Anti-Asthmatic Agents Phase 2
23 Autonomic Agents Phase 2
24 Bronchodilator Agents Phase 2
25
Simvastatin Approved 79902-63-9 54454
26
Ibuprofen Approved 15687-27-1 3672
27
Pioglitazone Approved, Investigational 111025-46-8 4829
28
tannic acid Approved 1401-55-4
29
Ethanol Approved 64-17-5 702
30
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
31
Caffeine Approved 58-08-2 2519
32
Coenzyme Q10 Approved, Investigational, Nutraceutical Early Phase 1 303-98-0 5281915
33
Sulforaphane Investigational 4478-93-7, 142825-10-3 5350
34 Ubiquinone Early Phase 1
35 Vitamins Early Phase 1
36 Nutrients Early Phase 1
37 Micronutrients Early Phase 1
38 Trace Elements Early Phase 1
39 Cyclooxygenase Inhibitors
40 Hydroxymethylglutaryl-CoA Reductase Inhibitors
41 Hypolipidemic Agents
42 Lipid Regulating Agents
43 Anticholesteremic Agents
44 Hypoglycemic Agents
45 Antimetabolites
46 Sulforafan
47 Protective Agents
48 Neurotransmitter Agents
49 Central Nervous System Stimulants
50 Purinergic P1 Receptor Antagonists

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Multicenter, Randomized, Placebo-Controlled, Double-Blind, Safety and Efficacy Study of Recombinant Human TNF Receptor-IgG Fusion Protein for Injection (Qiangke®) to Treat Moderate to Severe Plaque Psoriasis Unknown status NCT02701205 Phase 3 placebo
2 A Single Center, Open-label, Randomized Controlled Clinical Trial on the Early and Whole Course Nutritional Support by Nutren® Optimum During Intensity Modulated Radiation Therapy for Nasopharyngeal Carcinoma Not yet recruiting NCT03344068 Phase 2, Phase 3 Chemotherapy
3 A 2-Year, Dose Range-Finding, Adaptive-Design Study of the Effects of SCH 527123 in Subjects With Moderate to Severe COPD Terminated NCT01006616 Phase 2 Navarixin;Placebo;Rescue medication
4 Bronchiectasis in COPD Patients : Role of Prophylaxis With Inhaled Steroids and Antibiotic on the Natural History of the Disease Terminated NCT00524095 Phase 2 azithromycin and fluticasone;fluticasone and azithromycin
5 Proof-of-Concept and Dose Range-Finding Study of SCH 527123 in Subjects With Severe Asthma Withdrawn NCT01006161 Phase 2 SCH 527123;SCH 527123;SCH 527123;SCH 527123
6 Assessing Bioavailability and Effects of Ubiquinol Supplementation on Biomarkers of Mitochondrial Function/Integrity, Metabolic Dysfunction, and Circulating Alarmins in Burn Patients Unknown status NCT02251626 Early Phase 1
7 A Pilot Study Evaluating the Effect of Pioglitazone, Simvastatin, and Ibuprofen on Neutrophil Migration in Vivo in Healthy Subjects Completed NCT00531882 Pioglitazone;Simvastatin;Ibuprofen
8 Assessment of the Predictive Value of Fecal Calprotectin for the Outcome of Severe Alcoholic Hepatitis Completed NCT02808663
9 Evaluation of the Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation, Measures of Oxidative Stress, and Neutrophil Migration to Mucosal Surfaces in Healthy and CF Subjects Completed NCT01315665
10 Investigation Into Inflammatory Mechanisms in Airway Cells in Smokers and Non-smokers With Inflammatory Lung Disease. Completed NCT00147069
11 Influence of Lifestyle Factors on Neutrophil Migration Pilot Study Recruiting NCT02411318 ProLab 200mg caffeine capsule
12 Effect of Resistin on Neutrophil Function in Patients With Septic Shock and Acute Kidney Injury Recruiting NCT03146546
13 Effects of Resistin on Neutrophil Function Withdrawn NCT03626870

Search NIH Clinical Center for Neutrophil Migration

Genetic Tests for Neutrophil Migration

Anatomical Context for Neutrophil Migration

MalaCards organs/tissues related to Neutrophil Migration:

41
Neutrophil, Lung, Endothelial, Skin, Monocytes, Liver, Bone

Publications for Neutrophil Migration

Articles related to Neutrophil Migration:

(show top 50) (show all 2410)
# Title Authors PMID Year
1
A familial defect of neutrophil chemotaxis with asthma, eczema, and recurrent skin infections. 8
865918 1977
2
Defective chemotaxis in monosomy-7. 8
264599 1977
3
A new familial defect of neutrophil movement. 8
4718002 1973
4
Effects of Tithonia diversifolia (Asteraceae) extract on innate inflammatory responses. 38
31252095 2019
5
Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation. 38
31427815 2019
6
Extracellular vesicles as mediators of in vitro neutrophil swarming on a large-scale microparticle array. 38
31343025 2019
7
Identification of microRNAs and messenger RNAs involved in human umbilical cord mesenchymal stem cell treatment of ischemic cerebral infarction using integrated bioinformatics analysis. 38
31089061 2019
8
Estradiol inhibits fMLP-induced neutrophil migration and superoxide production by upregulating MKP-2 and dephosphorylating ERK. 38
31401382 2019
9
Efficacy of a phenol derivative, isopropyl vanillate, as an anti-inflammatory agent: A new small molecule inhibitor of COX and neutrophil migration. 38
31112325 2019
10
Inducible overexpression of zebrafish microRNA-722 suppresses chemotaxis of human neutrophil like cells. 38
31176200 2019
11
Targeting nitric oxide as a key modulator of sepsis, arthritis and pain. 38
31051258 2019
12
A microscale, full-thickness, human skin on a chip assay simulating neutrophil responses to skin infection and antibiotic treatments. 38
31423506 2019
13
A neutrophil-centric view of chemotaxis. 38
31420450 2019
14
Phosphoinositide-3 kinase gamma regulates caspase-1 activation and leukocyte recruitment in acute murine gout. 38
31392775 2019
15
Anti-inflammatory and anti-Candida effects of Brazilian organic propolis, a promising source of bioactive molecules and functional food. 38
31369255 2019
16
Heterozygous activating mutation in RAC2 causes infantile-onset combined immunodeficiency with susceptibility to viral infections. 38
31071452 2019
17
SN-38, the active metabolite of irinotecan, inhibits the acute inflammatory response by targeting toll-like receptor 4. 38
31011814 2019
18
Hesperidin, a citrus flavanone glycoside, accelerates the gastric healing process of acetic acid-induced ulcer in rats. 38
31095933 2019
19
Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis. 38
31429784 2019
20
Long non‑coding RNA DLEU1 promotes cell proliferation of glioblastoma multiforme. 38
31257517 2019
21
CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis. 38
31270368 2019
22
Netrin-1 Dampens Hypobaric Hypoxia-Induced Lung Injury in Mice. 38
31329475 2019
23
BAY 41-2272 inhibits human neutrophil functions. 38
31376626 2019
24
Estradiol replacement therapy regulates innate immune response in ovariectomized arthritic mice. 38
31055232 2019
25
The nitrated fatty acid, 10-nitrooleate inhibits the neutrophil chemotaxis via peroxisome proliferator-activated receptor gamma in CLP-induced sepsis in mice. 38
30981081 2019
26
A CRTH2 antagonist, CT-133, suppresses NF-κB signalling to relieve lipopolysaccharide-induced acute lung injury. 38
30951719 2019
27
Regulation of the inflammatory response by vascular grafts modified with Aspirin-Triggered Resolvin D1 promotes blood vessel regeneration. 38
31351251 2019
28
Use of autologous 99mTechnetium-labelled neutrophils to quantify lung neutrophil clearance in COPD. 38
30674586 2019
29
P2X3 receptors contribute to muscle pain induced by static contraction by a mechanism dependent on neutrophil migration. 38
31115830 2019
30
TREM-1 regulates neutrophil chemotaxis by promoting NOX-dependent superoxide production. 38
30667543 2019
31
Inhibitory effect of Lonchocarpus araripensis lectin in rat acute models of inflammation. 38
31241705 2019
32
Anti-inflammatory activity of β-caryophyllene combined with docosahexaenoic acid in a model of sepsis induced by Staphylococcus aureus in mice. 38
31206687 2019
33
Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice. 38
31218550 2019
34
Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1. 38
31036565 2019
35
The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration. 38
30748033 2019
36
Ouabain reduces the expression of the adhesion molecule CD18 in neutrophils. 38
31087249 2019
37
Comprehensive characterization of bioactive phenols from new Brazilian superfruits by LC-ESI-QTOF-MS, and their ROS and RNS scavenging effects and anti-inflammatory activity. 38
30658745 2019
38
Differential Macrophage Subsets in Muscle Damage Induced by a K49-PLA2 from Bothrops jararacussu Venom Modulate the Time Course of the Regeneration Process. 38
31123944 2019
39
Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis. 38
30565271 2019
40
Toll-like receptor 2 and toll-like receptor 4 responses regulate neutrophil infiltration into the junctional epithelium and significantly contribute to the composition of the oral microbiota. 38
31111967 2019
41
Resistin directly inhibits bacterial killing in neutrophils. 38
31147868 2019
42
Induced Pluripotent Stem Cells Regulate Triggering Receptor Expressed on Myeloid Cell-1 Expression and the p38 Mitogen-Activated Protein Kinase Pathway in Endotoxin-Induced Acute Lung Injury. 38
30681755 2019
43
Protein Kinase C-Delta (PKCδ) Tyrosine Phosphorylation is a Critical Regulator of Neutrophil-Endothelial Cell Interaction in Inflammation. 38
30095599 2019
44
Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post-ischemia/reperfusion injury. 38
30632166 2019
45
Interleukin-17/interleukin-17 receptor axis elicits intestinal neutrophil migration, restrains gut dysbiosis and lipopolysaccharide translocation in high-fat diet-induced metabolic syndrome model. 38
30472727 2019
46
Estradiol impairs epithelial CXCL1 gradient in the cervix to delay neutrophil transepithelial migration during insemination. 38
30807979 2019
47
Inhibition of neutrophil migration and reduction of oxidative stress by ethyl p-coumarate in acute and chronic inflammatory models. 38
30668327 2019
48
Direct Inhibitory Effect of the PDE4 Inhibitor Roflumilast on Neutrophil Migration in Chronic Obstructive Pulmonary Disease. 38
30395484 2019
49
LL-37 and its analog FF/CAP18 attenuate neutrophil migration in sepsis-induced acute lung injury. 38
30537236 2019
50
Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice. 38
30971272 2019

Variations for Neutrophil Migration

Expression for Neutrophil Migration

Search GEO for disease gene expression data for Neutrophil Migration.

Pathways for Neutrophil Migration

Pathways related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 RAC1 MYH9 MAPK3 MAPK1 ITGB2 ITGAM
2
Show member pathways
13.81 RAC2 RAC1 MYH9 MAPK3 MAPK1 ITGB2
3
Show member pathways
13.56 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
4
Show member pathways
13.44 RAC2 RAC1 ITGB2 ITGAM IRAK4 CXCR2
5
Show member pathways
13.4 MAPK3 MAPK1 ITGB2 ITGAM IRAK4 ICAM1
6
Show member pathways
13.35 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
7
Show member pathways
13.31 RAC2 RAC1 MYH9 MAPK3 MAPK1 CXCR2
8
Show member pathways
13.2 RAC2 RAC1 MYH9 MAPK3 MAPK1 ITGB2
9
Show member pathways
13.12 RAC1 MAPK3 MAPK1 IRAK4 CXCL8
10
Show member pathways
13.11 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
11
Show member pathways
13.05 RAC2 RAC1 MYH9 MAPK3 MAPK1
12
Show member pathways
13.02 RAC2 RAC1 MYH9 ITGB2 ITGAM
13
Show member pathways
12.95 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
14
Show member pathways
12.91 RAC2 RAC1 MAPK3 MAPK1 ITGAM
15
Show member pathways
12.91 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
16
Show member pathways
12.91 RAC2 RAC1 MYH9 MAPK3 MAPK1 ITGB2
17
Show member pathways
12.91 RAC2 RAC1 MAPK3 MAPK1 IRAK4 ICAM1
18 12.88 RAC2 RAC1 MAPK3 MAPK1 CXCL8
19
Show member pathways
12.88 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ICAM1
20
Show member pathways
12.87 RAC2 RAC1 MAPK3 MAPK1 CXCR2 CXCR1
21
Show member pathways
12.86 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
22
Show member pathways
12.85 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
23 12.82 RAC2 RAC1 MAPK3 MAPK1 IRAK4
24
Show member pathways
12.78 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
25
Show member pathways
12.7 RAC2 RAC1 ITGB2 ITGAM ICAM1
26
Show member pathways
12.64 RAC1 MYH9 MAPK3 MAPK1
27
Show member pathways
12.62 RAC2 RAC1 MAPK3 MAPK1
28 12.57 RAC2 RAC1 MYH9 ITGB2
29
Show member pathways
12.57 RAC2 RAC1 MAPK3 MAPK1
30 12.54 RAC2 RAC1 MYH9 MAPK3 MAPK1 ITGB2
31
Show member pathways
12.53 RAC1 CXCR2 CXCR1 CXCL8
32
Show member pathways
12.5 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ICAM1
33
Show member pathways
12.49 RAC1 MAPK3 MAPK1 IRAK4
34
Show member pathways
12.47 RAC1 MAPK3 MAPK1 ICAM1
35
Show member pathways
12.46 RAC1 MAPK3 MAPK1 IRAK4
36
Show member pathways
12.46 RAC2 RAC1 MAPK3 MAPK1
37
Show member pathways
12.45 RAC1 MAPK3 MAPK1 ICAM1
38
Show member pathways
12.45 RAC2 RAC1 MAPK3 MAPK1
39
Show member pathways
12.44 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
40
Show member pathways
12.39 RAC2 RAC1 MAPK3 MAPK1
41 12.39 RAC2 RAC1 MAPK3 MAPK1
42
Show member pathways
12.38 RAC1 MAPK3 MAPK1 IRAK4 CXCL8
43
Show member pathways
12.36 RAC1 MYH9 MAPK3 MAPK1
44
Show member pathways
12.3 CXCR2 CXCR1 CXCL8
45
Show member pathways
12.3 MAPK3 MAPK1 ITGB2 ITGAM IRAK4
46
Show member pathways
12.3 RAC2 RAC1 MAPK3 MAPK1 CXCR2 CXCR1
47 12.29 RAC2 RAC1 MAPK3 MAPK1
48
Show member pathways
12.29 RAC2 RAC1 MAPK3 MAPK1
49
Show member pathways
12.28 MAPK3 MAPK1 IRAK4 CXCL8
50
Show member pathways
12.26 MAPK3 MAPK1 ITGB2 ITGAM

GO Terms for Neutrophil Migration

Cellular components related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.77 ITGB2 ITGAM ICAM1 CXCR2 CXCR1
2 plasma membrane GO:0005886 9.77 UMOD RAC2 RAC1 MYH9 MAPK3 MAPK1
3 membrane raft GO:0045121 9.71 ITGB2 ITGAM ICAM1 CD177
4 specific granule membrane GO:0035579 9.65 ITGB2 ITGAM CD177
5 tertiary granule membrane GO:0070821 9.63 ITGB2 ITGAM CD177
6 pseudopodium GO:0031143 9.49 MAPK3 MAPK1
7 secretory granule membrane GO:0030667 9.46 RAC1 CXCR2 CXCR1 CD177
8 plasma membrane raft GO:0044853 9.43 ITGB2 ITGAM CD177
9 integrin alphaM-beta2 complex GO:0034688 9.32 ITGB2 ITGAM
10 focal adhesion GO:0005925 9.17 RAC2 RAC1 MYH9 MAPK3 MAPK1 ITGB2
11 extracellular exosome GO:0070062 10.03 UMOD RAC2 RAC1 MYH9 ITGB2 ITGAM

Biological processes related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.91 ITGB2 ITGAM IRAK4 ICAM1 CXCL8
2 neutrophil degranulation GO:0043312 9.91 RAC1 MAPK1 ITGB2 ITGAM CXCR2 CXCR1
3 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 9.89 RAC1 MAPK3 MAPK1
4 Fc-epsilon receptor signaling pathway GO:0038095 9.87 RAC1 MAPK3 MAPK1
5 phagocytosis, engulfment GO:0006911 9.86 MYH9 ITGB2 ITGAM
6 integrin-mediated signaling pathway GO:0007229 9.85 MYH9 ITGB2 ITGAM
7 cellular response to tumor necrosis factor GO:0071356 9.85 MAPK3 MAPK1 ICAM1 CXCL8
8 leukocyte migration GO:0050900 9.85 MYH9 ITGB2 ITGAM ICAM1 CD177
9 calcium-mediated signaling GO:0019722 9.84 CXCR2 CXCR1 CXCL8
10 chemokine-mediated signaling pathway GO:0070098 9.82 CXCR2 CXCR1 CXCL8
11 neutrophil chemotaxis GO:0030593 9.8 ITGB2 CXCR2 CXCR1 CXCL8
12 cellular response to organic substance GO:0071310 9.75 MAPK3 MAPK1 ICAM1
13 Rac protein signal transduction GO:0016601 9.71 RAC2 RAC1
14 lung morphogenesis GO:0060425 9.71 MAPK3 MAPK1
15 positive regulation of lamellipodium assembly GO:0010592 9.71 RAC2 RAC1
16 cell projection assembly GO:0030031 9.71 RAC2 RAC1
17 receptor internalization GO:0031623 9.71 ITGB2 CXCR2 CXCR1 CXCL8
18 microglial cell activation GO:0001774 9.7 ITGB2 ITGAM
19 face development GO:0060324 9.7 MAPK3 MAPK1
20 toll-like receptor 4 signaling pathway GO:0034142 9.69 ITGB2 ITGAM
21 positive regulation of telomere capping GO:1904355 9.69 MAPK3 MAPK1
22 dendritic cell chemotaxis GO:0002407 9.69 CXCR2 CXCR1
23 regulation of ossification GO:0030278 9.68 MAPK3 MAPK1
24 cellular response to dopamine GO:1903351 9.68 MAPK3 MAPK1
25 amyloid-beta clearance GO:0097242 9.68 ITGB2 ITGAM
26 neutrophil activation GO:0042119 9.67 CXCR2 CXCL8
27 regulation of stress-activated MAPK cascade GO:0032872 9.66 MAPK3 MAPK1
28 outer ear morphogenesis GO:0042473 9.65 MAPK3 MAPK1
29 Bergmann glial cell differentiation GO:0060020 9.65 MAPK3 MAPK1
30 acute inflammatory response to antigenic stimulus GO:0002438 9.65 ICAM1 CXCR2
31 positive regulation of superoxide anion generation GO:0032930 9.65 ITGB2 ITGAM CD177
32 regulation of early endosome to late endosome transport GO:2000641 9.64 MAPK3 MAPK1
33 trachea formation GO:0060440 9.63 MAPK3 MAPK1
34 regulation of hydrogen peroxide metabolic process GO:0010310 9.62 RAC2 RAC1
35 regulation of cellular pH GO:0030641 9.62 MAPK3 MAPK1
36 leukocyte cell-cell adhesion GO:0007159 9.62 UMOD ITGB2 ICAM1 CD177
37 caveolin-mediated endocytosis GO:0072584 9.61 MAPK3 MAPK1
38 response to epidermal growth factor GO:0070849 9.61 MAPK3 MAPK1
39 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.61 ITGB2 ITGAM CD177
40 regulation of respiratory burst GO:0060263 9.6 RAC2 RAC1
41 regulation of Golgi inheritance GO:0090170 9.59 MAPK3 MAPK1
42 negative regulation of dopamine metabolic process GO:0045963 9.58 ITGB2 ITGAM
43 positive regulation of prostaglandin-E synthase activity GO:2000363 9.57 ITGB2 ITGAM
44 cardiac neural crest cell development involved in heart development GO:0061308 9.56 MAPK3 MAPK1
45 interleukin-8-mediated signaling pathway GO:0038112 9.52 CXCR2 CXCR1
46 positive regulation of neutrophil chemotaxis GO:0090023 9.46 RAC2 RAC1 CXCR2 CXCL8
47 positive regulation of neutrophil degranulation GO:0043315 9.43 ITGB2 ITGAM CD177
48 chemotaxis GO:0006935 9.43 RAC2 RAC1 MAPK1 CXCR2 CXCR1 CXCL8
49 positive regulation of microglial cell activation GO:1903980 9.36 ITGAM
50 neutrophil migration GO:1990266 8.92 UMOD ITGB2 IRAK4 CD177

Molecular functions related to Neutrophil Migration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase activity GO:0004708 9.4 MAPK3 MAPK1
2 MAP kinase activity GO:0004707 9.37 MAPK3 MAPK1
3 C-X-C chemokine receptor activity GO:0016494 9.32 CXCR2 CXCR1
4 complement component C3b binding GO:0001851 9.26 ITGB2 ITGAM
5 integrin binding GO:0005178 9.26 MYH9 ITGB2 ICAM1 CD177
6 interleukin-8 binding GO:0019959 9.16 CXCR2 CXCR1
7 interleukin-8 receptor activity GO:0004918 8.62 CXCR2 CXCR1

Sources for Neutrophil Migration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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