Aliases & Classifications for Neutrophil Migration

MalaCards integrated aliases for Neutrophil Migration:

Name: Neutrophil Migration 56
Neutrophil Chemotactic Response, Abnormal 56
Neutrophil Chemotactic Response; Ncr 56
Neutrophil Chemotactic Response 56
Ncr 56
Nm 56

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
neutrophil migration:
Inheritance autosomal dominant inheritance


Summaries for Neutrophil Migration

MalaCards based summary : Neutrophil Migration, also known as neutrophil chemotactic response, abnormal, is related to peritonitis and pulmonary disease, chronic obstructive. An important gene associated with Neutrophil Migration is NM (Neutrophil Migration), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Etanercept and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, lung and endothelial, and related phenotypes are immunodeficiency and asthma

More information from OMIM: 162820

Related Diseases for Neutrophil Migration

Diseases related to Neutrophil Migration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 peritonitis 30.2 ITGB2 ITGAM ICAM1 CXCL8
2 pulmonary disease, chronic obstructive 29.8 ITGAM CXCR2 CXCR1 CXCL8
3 uveitis 29.7 ICAM1 CXCR1 CXCL8
4 lung disease 29.7 ICAM1 CXCR2 CXCR1 CXCL8
5 cystitis 29.6 UMOD ICAM1 CXCL8
6 allergic asthma 29.5 ITGB2 ITGAM ICAM1 CXCL8
7 pyelonephritis 29.5 UMOD CXCR2 CXCR1 CXCL8
8 pulmonary fibrosis, idiopathic 29.4 ITGAM CXCR2 CXCR1 CXCL8
9 chronic granulomatous disease 29.4 RAC2 RAC1 ICAM1 CXCL8
10 pneumonia 29.4 ITGAM ICAM1 CXCR2 CXCL8
11 bacterial infectious disease 29.3 ITGB2 ITGAM IRAK4 CXCR1 CXCL8
12 dermatitis, atopic 29.0 ITGAM ICAM1 CXCR1 CXCL8
13 otitis media 28.9 IRAK4 ICAM1 CXCL8
14 pertussis 28.8 MAPK3 MAPK1 ITGB2 ITGAM IRAK4 CXCL8
15 immune deficiency disease 28.8 RAC2 ITGB2 ITGAM IRAK4
16 meningitis 28.7 IRAK4 ICAM1 CXCL8
17 psoriasis 28.7 MAPK1 ITGB2 ICAM1 CXCR1 CXCL8
18 diabetes mellitus 28.2 UMOD MAPK3 MAPK1 ITGB2 ITGAM ICAM1
19 idiopathic anterior uveitis 10.3 CXCR1 CXCL8
20 hepatitis c virus 10.3
21 retinitis pigmentosa 47 10.3 RAC2 RAC1
22 idiopathic eosinophilic pneumonia 10.3 ITGB2 ITGAM
23 mycetoma 10.2 CXCR2 CXCL8
24 annular erythema 10.2 ITGB2 ICAM1
25 severe combined immunodeficiency 10.2
26 toxicodendron dermatitis 10.2 ICAM1 CXCL8
27 herpes simplex virus keratitis 10.2 ICAM1 CXCL8
28 acute pyelonephritis 10.1 CXCR2 CXCR1 CXCL8
29 hepatitis c 10.1
30 fibrosarcoma 10.1
31 mouth disease 10.1
32 pyelitis 10.1 UMOD CXCR1 CXCL8
33 proteasome-associated autoinflammatory syndrome 1 10.1
34 vesicoureteral reflux 1 10.1 UMOD CXCR1 CXCL8
35 inflammatory bowel disease 10.1
36 cytokine deficiency 10.1
37 mooren's ulcer 10.0 ITGB2 ICAM1
38 ulcerative colitis 10.0
39 granulocytopenia 10.0 ITGB2 ITGAM
40 shwartzman phenomenon 10.0 ITGAM ICAM1
41 cystic fibrosis 10.0
42 acute cystitis 10.0
43 periodontitis 10.0
44 vasculitis 10.0
45 colorectal cancer 10.0
46 hypertension, essential 10.0
47 down syndrome 10.0
48 lung cancer 10.0
49 leukemia, acute myeloid 10.0
50 cervical cancer 10.0

Graphical network of the top 20 diseases related to Neutrophil Migration:



Diseases related to Neutrophil Migration

Symptoms & Phenotypes for Neutrophil Migration

Human phenotypes related to Neutrophil Migration:

31 (show all 8)
# Description HPO Frequency HPO Source Accession
1 immunodeficiency 31 HP:0002721
2 asthma 31 HP:0002099
3 eczema 31 HP:0000964
4 abnormal leukocyte morphology 31 HP:0001881
5 congenital ichthyosiform erythroderma 31 HP:0007431
6 recurrent skin infections 31 HP:0001581
7 recurrent bacterial infections 31 HP:0002718
8 recurrent fungal infections 31 HP:0002841

Symptoms via clinical synopsis from OMIM:

56
Immune:
immunodeficiency

Skin:
congenital ichthyosis

Clinical features from OMIM:

162820

MGI Mouse Phenotypes related to Neutrophil Migration:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 CXCR2 ICAM1 IRAK4 ITGAM ITGB2 MAPK1
2 cardiovascular system MP:0005385 9.97 CXCR2 ICAM1 ITGB2 MAPK1 MAPK3 MYH9
3 hematopoietic system MP:0005397 9.93 CD177 CXCR1 CXCR2 ICAM1 IRAK4 ITGAM
4 homeostasis/metabolism MP:0005376 9.73 CXCR1 CXCR2 ICAM1 IRAK4 ITGAM ITGB2
5 immune system MP:0005387 9.4 CD177 CXCR2 ICAM1 IRAK4 ITGAM ITGB2

Drugs & Therapeutics for Neutrophil Migration

Drugs for Neutrophil Migration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 3 185243-69-0
2
Fluorouracil Approved Phase 2, Phase 3 51-21-8 3385
3
Nedaplatin Approved, Investigational Phase 2, Phase 3 95734-82-0
4 Analgesics, Non-Narcotic Phase 3
5 Analgesics Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 3
7 Antirheumatic Agents Phase 3
8 Immunologic Factors Phase 3
9 Gastrointestinal Agents Phase 3
10 Immunosuppressive Agents Phase 3
11
Fluticasone Approved, Experimental Phase 2 90566-53-3 62924
12
Azithromycin Approved Phase 2 83905-01-5 447043 55185
13 Anti-Infective Agents Phase 2
14 Cholinergic Antagonists Phase 2
15 Anti-Inflammatory Agents Phase 2
16 Respiratory System Agents Phase 2
17 Anti-Allergic Agents Phase 2
18 Anti-Bacterial Agents Phase 2
19 Anti-Asthmatic Agents Phase 2
20 Dermatologic Agents Phase 2
21 Bronchodilator Agents Phase 2
22 Antibiotics, Antitubercular Phase 2
23
Pioglitazone Approved, Investigational 111025-46-8 4829
24
Ibuprofen Approved 15687-27-1 3672
25
Simvastatin Approved 79902-63-9 54454
26
Remifentanil Approved 132875-61-7 60815
27
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
28
Caffeine Approved 58-08-2 2519
29
tannic acid Approved 1401-55-4
30
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
31
Ethanol Approved 64-17-5 702
32
Coenzyme Q10 Approved, Investigational, Nutraceutical Early Phase 1 303-98-0 5281915
33
Sulforaphane Investigational 142825-10-3, 4478-93-7 5350
34 Trace Elements Early Phase 1
35 Vitamins Early Phase 1
36 Nutrients Early Phase 1
37 Micronutrients Early Phase 1
38 Ubiquinone Early Phase 1
39 Lipid Regulating Agents
40 Hydroxymethylglutaryl-CoA Reductase Inhibitors
41 Cyclooxygenase Inhibitors
42 Anticholesteremic Agents
43 Hypoglycemic Agents
44 Hypolipidemic Agents
45 Antimetabolites
46 Protective Agents
47 Sulforafan
48 Eusol
49 Sodium hypochlorite
50 Narcotics

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 A Multicenter, Randomized, Placebo-Controlled, Double-Blind, Safety and Efficacy Study of Recombinant Human TNF Receptor-IgG Fusion Protein for Injection (Qiangke®) to Treat Moderate to Severe Plaque Psoriasis Unknown status NCT02701205 Phase 3 placebo
2 A Single Center, Open-label, Randomized Controlled Clinical Trial on the Early and Whole Course Nutritional Support by Nutren® Optimum During Intensity Modulated Radiation Therapy for Nasopharyngeal Carcinoma Not yet recruiting NCT03344068 Phase 2, Phase 3 Chemotherapy
3 A 2-Year, Dose Range-Finding, Adaptive-Design Study of the Effects of SCH 527123 in Subjects With Moderate to Severe COPD Terminated NCT01006616 Phase 2 Navarixin;Placebo;Rescue medication
4 Bronchiectasis in COPD Patients : Role of Prophylaxis With Inhaled Steroids and Antibiotic on the Natural History of the Disease Terminated NCT00524095 Phase 2 azithromycin and fluticasone;fluticasone and azithromycin
5 Proof-of-Concept and Dose Range-Finding Study of SCH 527123 in Subjects With Severe Asthma Withdrawn NCT01006161 Phase 2 SCH 527123;SCH 527123;SCH 527123;SCH 527123
6 Assessing Bioavailability and Effects of Ubiquinol Supplementation on Biomarkers of Mitochondrial Function/Integrity, Metabolic Dysfunction, and Circulating Alarmins in Burn Patients Unknown status NCT02251626 Early Phase 1
7 A Pilot Study Evaluating the Effect of Pioglitazone, Simvastatin, and Ibuprofen on Neutrophil Migration in Vivo in Healthy Subjects Completed NCT00531882 Pioglitazone;Simvastatin;Ibuprofen
8 Assessment of the Predictive Value of Fecal Calprotectin for the Outcome of Severe Alcoholic Hepatitis Completed NCT02808663
9 Evaluation of the Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation, Measures of Oxidative Stress, and Neutrophil Migration to Mucosal Surfaces in Healthy and CF Subjects Completed NCT01315665
10 Investigation Into Inflammatory Mechanisms in Airway Cells in Smokers and Non-smokers With Inflammatory Lung Disease. Completed NCT00147069
11 The Frequency Of Sodium Hypochlorite Extrusion During Endodontic Treatments: A Clinical Study Recruiting NCT04262362
12 Effect of Resistin on Neutrophil Function in Patients With Septic Shock and Acute Kidney Injury Recruiting NCT03146546
13 Self-Reported Pain and Nadir White Blood Cell/Absolute Neutrophil Count in Women 45 and Under Compared to Older Women Receiving Pegfilgrastim (or Biosimilar Substitution) While Undergoing Chemotherapy for Non-Metastatic Breast Cancer Active, not recruiting NCT04174742 pegfilgrastim
14 Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB) Not yet recruiting NCT04296071
15 Inflammatory Effect Comparison Between Fentanyl and Remifentanil in Mastectomy Under General Anesthesia Not yet recruiting NCT04435925 Remifentanil;Fentanyl
16 Influence of Lifestyle Factors on Neutrophil Migration Pilot Study Suspended NCT02411318 ProLab 200mg caffeine capsule;Glucose Tolerance Drink
17 Effects of Resistin on Neutrophil Function Withdrawn NCT03626870

Search NIH Clinical Center for Neutrophil Migration

Genetic Tests for Neutrophil Migration

Anatomical Context for Neutrophil Migration

MalaCards organs/tissues related to Neutrophil Migration:

40
Neutrophil, Lung, Endothelial, Skin, Monocytes, Liver, Bone

Publications for Neutrophil Migration

Articles related to Neutrophil Migration:

(show top 50) (show all 2502)
# Title Authors PMID Year
1
A familial defect of neutrophil chemotaxis with asthma, eczema, and recurrent skin infections. 56
865918 1977
2
Defective chemotaxis in monosomy-7. 56
264599 1977
3
A new familial defect of neutrophil movement. 56
4718002 1973
4
A novel approach to treatment of thromboembolic stroke in mice: Redirecting neutrophils toward a peripherally implanted CXCL1-soaked sponge. 61
32360283 2020
5
P2X3 and P2X2/3 receptors activation induces articular hyperalgesia by an indirect sensitization of the primary afferent nociceptor in the rats' knee joint. 61
32145326 2020
6
Differences in Staining for Neutrophil Elastase and its Controlling Inhibitor SLPI Reveal Heterogeneity among Neutrophils in Psoriasis. 61
31945345 2020
7
Activation of PPAR-γ induces macrophage polarization and reduces neutrophil migration mediated by heme oxygenase 1. 61
32388213 2020
8
A C-terminal fragment of adhesion protein Fibulin7 regulates neutrophil migration and functions and improves survival in LPS induced systemic inflammation. 61
32388247 2020
9
The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in periodontitis. 61
32531826 2020
10
Microglia-released leukotriene B4 promotes neutrophil infiltration and microglial activation following intracerebral hemorrhage. 61
32544870 2020
11
The Clinical and Inflammatory Relationships between Periodontitis and Chronic Obstructive Pulmonary Disease. 61
32567697 2020
12
Effects of 2',6'-dihydroxy-4'-methoxydihidrochalcone on innate inflammatory response. 61
32548784 2020
13
Thymoquinone attenuates IgE-mediated allergic response via pi3k-Akt-NFκB pathway and upregulation of the Nrf2-HO1 axis. 61
32212163 2020
14
Hif-1alpha stabilisation is protective against infection in zebrafish comorbid models. 61
32485057 2020
15
Establishment of a scalable microfluidic assay for characterization of population-based neutrophil chemotaxis. 61
31971608 2020
16
Neutrophil Swarming in Damaged Tissue Is Orchestrated by Connexins and Cooperative Calcium Alarm Signals. 61
32502410 2020
17
Ouabain reduces the expression of the adhesion molecule CD18 in neutrophils. 61
31087249 2020
18
IL-33/ST2 pathway regulates neutrophil migration and predicts outcome in patients with severe alcoholic hepatitis. 61
31953139 2020
19
Ginsenoside Rg3 ameliorates acute exacerbation of COPD by suppressing neutrophil migration. 61
32278128 2020
20
Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis. 61
32265339 2020
21
Truncation of CXCL8 to CXCL8(9-77) enhances actin polymerization and in vivo migration of neutrophils. 61
32272490 2020
22
CXCR2 antagonist for patients with chronic obstructive pulmonary disease with chronic mucus hypersecretion: a phase 2b trial. 61
32532258 2020
23
Synthesis and biological activities of a nitro-shiff base compound as a potential anti-inflammatory agent. 61
32160953 2020
24
Chemical structure, anti-inflammatory and antinociceptive activities of a sulfated polysaccharide from Gracilaria intermedia algae. 61
32450322 2020
25
Pre-existing antibody-mediated adverse effects prevent the clinical development of a bacterial anti-inflammatory protein. 61
32471891 2020
26
Hv1/VSOP regulates neutrophil directional migration and ERK activity by tuning ROS production. 61
32303121 2020
27
Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11. 61
32457448 2020
28
The immunotoxicity and neurobehavioral toxicity of zebrafish induced by famoxadone-cymoxanil. 61
31931321 2020
29
Intravenous antagomiR-494 lessens brain-infiltrating neutrophils by increasing HDAC2-mediated repression of multiple MMPs in experimental stroke. 61
32239566 2020
30
α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice. 61
32415495 2020
31
Expanding the anti-inflammatory potential of Moringa oleifera: topical effect of seed oil on skin inflammation and hyperproliferation. 61
32142866 2020
32
Neutrophilic urticarial dermatosis: an entity bridging monogenic and polygenic autoinflammatory disorders, and beyond. 61
31562783 2020
33
Increased ferritin levels in non-transfusion-dependent β°-thalassaemia/HbE are associated with reduced CXCR2 expression and neutrophil migration. 61
31884679 2020
34
IL-17C amplifies epithelial inflammation in human psoriasis and atopic eczema. 61
31793105 2020
35
Use of a biopolymer delivery system to investigate the influence of interleukin-4 on recruitment of neutrophils in equids. 61
32228258 2020
36
β2 integrin LFA1 mediates airway damage following neutrophil trans-epithelial migration during RSV infection. 61
32217648 2020
37
lncRNA MALAT1 Accelerates Skeletal Muscle Cell Apoptosis and Inflammatory Response in Sepsis by Decreasing BRCA1 Expression by Recruiting EZH2. 61
31830649 2020
38
The chemotactic properties of various topical brimonidine tartrate ophthalmic preparations. 61
32293549 2020
39
Mechanisms and Points of Control in the Spread of Inflammation: A Mathematical Investigation. 61
32222839 2020
40
Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment. 61
31866111 2020
41
Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation. 61
32203187 2020
42
Inula helenium and Grindelia squarrosa as a source of compounds with anti-inflammatory activity in human neutrophils and cultured human respiratory epithelium. 61
31644941 2020
43
Anti-inflammatory and anti-Candida Effects of Brazilian Organic Propolis, a Promising Source of Bioactive Molecules and Functional Food. 61
31369255 2020
44
Correction for Hsu et al., Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration. 61
32152120 2020
45
TAK1 inhibition in mouse astrocyte cultures ameliorates cytokine-induced chemokine production and neutrophil migration. 61
31782806 2020
46
Molecular characterization of a MOSPD2 homolog in the barbel steed (Hemibarbus labeo) and its involvement in monocyte/macrophage and neutrophil migration. 61
31927202 2020
47
Role of phosphodiesterase-4 inhibitors in chronic obstructive pulmonary disease. 61
32131571 2020
48
Peptidomic Analysis of Urine from Youths with Early Type 1 Diabetes Reveals Novel Bioactivity of Uromodulin Peptides In Vitro. 61
31879271 2020
49
Gastroprotective activity of hydroalcoholic extract of the leaves of Urera baccifera in rodents. 61
31836518 2020
50
Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation. 61
32149756 2020

Variations for Neutrophil Migration

Expression for Neutrophil Migration

Search GEO for disease gene expression data for Neutrophil Migration.

Pathways for Neutrophil Migration

Pathways related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 RAC1 MYH9 MAPK3 MAPK1 ITGB2 ITGAM
2
Show member pathways
13.75 RAC2 RAC1 MYH9 MAPK3 MAPK1 ITGB2
3
Show member pathways
13.56 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
4
Show member pathways
13.43 RAC2 RAC1 ITGB2 ITGAM IRAK4 CXCR2
5
Show member pathways
13.39 MAPK3 MAPK1 ITGB2 ITGAM IRAK4 ICAM1
6
Show member pathways
13.34 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
7
Show member pathways
13.31 RAC2 RAC1 MYH9 MAPK3 MAPK1 CXCR2
8
Show member pathways
13.14 RAC2 RAC1 MYH9 MAPK3 MAPK1 ITGB2
9
Show member pathways
13.1 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
10
Show member pathways
13.08 RAC1 MAPK3 MAPK1 IRAK4 CXCL8
11
Show member pathways
13.05 RAC2 RAC1 MYH9 MAPK3 MAPK1
12
Show member pathways
12.99 RAC2 RAC1 MYH9 ITGB2 ITGAM
13
Show member pathways
12.94 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
14
Show member pathways
12.93 RAC2 RAC1 MYH9 MAPK3 MAPK1 ITGB2
15
Show member pathways
12.92 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
16
Show member pathways
12.91 RAC2 RAC1 MAPK3 MAPK1 ITGAM
17
Show member pathways
12.9 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
18
Show member pathways
12.89 RAC2 RAC1 ITGB2 ICAM1 CXCL8
19 12.88 RAC2 RAC1 MAPK3 MAPK1 CXCL8
20
Show member pathways
12.88 RAC2 RAC1 MAPK3 MAPK1 CXCR2 CXCR1
21
Show member pathways
12.86 RAC1 MAPK3 MAPK1 ITGB2
22
Show member pathways
12.85 RAC1 MAPK3 MAPK1 IRAK4 ICAM1 CXCL8
23
Show member pathways
12.84 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
24
Show member pathways
12.83 RAC2 RAC1 MAPK3 MAPK1 IRAK4 ICAM1
25 12.81 RAC2 RAC1 MAPK3 MAPK1 IRAK4
26
Show member pathways
12.77 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
27
Show member pathways
12.7 MAPK3 MAPK1 ITGB2 ITGAM
28
Show member pathways
12.7 RAC2 RAC1 ITGB2 ITGAM ICAM1
29
Show member pathways
12.63 RAC1 MYH9 MAPK3 MAPK1
30
Show member pathways
12.62 RAC2 RAC1 MAPK3 MAPK1
31
Show member pathways
12.62 RAC1 MAPK3 MAPK1 IRAK4
32
Show member pathways
12.62 RAC1 MYH9 MAPK3 MAPK1
33 12.57 RAC2 RAC1 MYH9 ITGB2
34 12.57 RAC2 RAC1 MYH9 MAPK3 MAPK1 ITGB2
35
Show member pathways
12.56 RAC2 RAC1 MAPK3 MAPK1
36
Show member pathways
12.54 RAC2 RAC1 MAPK3 MAPK1
37
Show member pathways
12.52 RAC1 CXCR2 CXCR1 CXCL8
38
Show member pathways
12.51 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ICAM1
39
Show member pathways
12.49 RAC2 RAC1 MAPK3 MAPK1
40
Show member pathways
12.47 RAC1 MAPK3 MAPK1 ICAM1
41
Show member pathways
12.46 RAC2 RAC1 MAPK3 MAPK1
42
Show member pathways
12.45 RAC1 MAPK3 MAPK1 IRAK4
43
Show member pathways
12.45 RAC1 MAPK3 MAPK1 ICAM1
44 12.44 RAC1 MAPK3 MAPK1 CXCL8
45
Show member pathways
12.44 RAC2 RAC1 MAPK3 MAPK1
46
Show member pathways
12.43 RAC2 RAC1 MAPK3 MAPK1 ITGB2 ITGAM
47 12.39 MAPK3 MAPK1 ITGB2 ICAM1
48 12.39 RAC2 RAC1 MAPK3 MAPK1
49
Show member pathways
12.37 RAC1 MAPK3 MAPK1 IRAK4 CXCL8
50
Show member pathways
12.35 RAC1 MYH9 MAPK3 MAPK1

GO Terms for Neutrophil Migration

Cellular components related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.03 UMOD RAC2 RAC1 MYH9 ITGB2 ITGAM
2 cell surface GO:0009986 9.91 UMOD ITGB2 ITGAM ICAM1 CXCR2
3 cell GO:0005623 9.91 RAC2 MYH9 MAPK3 MAPK1 ICAM1 CXCR2
4 external side of plasma membrane GO:0009897 9.8 ITGB2 ITGAM ICAM1 CXCR2 CXCR1
5 membrane raft GO:0045121 9.78 ITGB2 ITGAM ICAM1 CD177
6 plasma membrane GO:0005886 9.77 UMOD RAC2 RAC1 MYH9 MAPK3 MAPK1
7 specific granule membrane GO:0035579 9.67 ITGB2 ITGAM CD177
8 tertiary granule membrane GO:0070821 9.63 ITGB2 ITGAM CD177
9 pseudopodium GO:0031143 9.52 MAPK3 MAPK1
10 plasma membrane raft GO:0044853 9.5 ITGB2 ITGAM CD177
11 secretory granule membrane GO:0030667 9.46 RAC1 CXCR2 CXCR1 CD177
12 integrin alphaM-beta2 complex GO:0034688 9.26 ITGB2 ITGAM
13 focal adhesion GO:0005925 9.17 RAC2 RAC1 MYH9 MAPK3 MAPK1 ITGB2

Biological processes related to Neutrophil Migration according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 intracellular signal transduction GO:0035556 10.03 RAC1 MAPK3 MAPK1 IRAK4 CXCL8
2 cell adhesion GO:0007155 10.01 RAC1 MYH9 ITGB2 ITGAM ICAM1 CD177
3 cell surface receptor signaling pathway GO:0007166 9.98 MAPK3 MAPK1 CXCR2 CXCR1
4 cytokine-mediated signaling pathway GO:0019221 9.91 ITGB2 ITGAM IRAK4 ICAM1 CXCL8
5 neutrophil degranulation GO:0043312 9.91 RAC1 MAPK1 ITGB2 ITGAM CXCR2 CXCR1
6 phagocytosis, engulfment GO:0006911 9.87 MYH9 ITGB2 ITGAM
7 integrin-mediated signaling pathway GO:0007229 9.85 MYH9 ITGB2 ITGAM
8 calcium-mediated signaling GO:0019722 9.85 CXCR2 CXCR1 CXCL8
9 cellular response to tumor necrosis factor GO:0071356 9.85 MAPK3 MAPK1 ICAM1 CXCL8
10 leukocyte migration GO:0050900 9.85 MYH9 ITGB2 ITGAM ICAM1 CD177
11 chemokine-mediated signaling pathway GO:0070098 9.83 CXCR2 CXCR1 CXCL8
12 regulation of cell shape GO:0008360 9.83 RAC2 RAC1 MYH9 ITGB2 ICAM1
13 neutrophil chemotaxis GO:0030593 9.78 ITGB2 CXCR2 CXCR1 CXCL8
14 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.74 ITGB2 ITGAM CD177
15 cellular response to organic substance GO:0071310 9.73 MAPK3 MAPK1 ICAM1
16 positive regulation of macrophage chemotaxis GO:0010759 9.71 MAPK3 MAPK1
17 face development GO:0060324 9.71 MAPK3 MAPK1
18 toll-like receptor 4 signaling pathway GO:0034142 9.71 ITGB2 ITGAM
19 receptor internalization GO:0031623 9.71 ITGB2 CXCR2 CXCR1 CXCL8
20 positive regulation of telomere capping GO:1904355 9.7 MAPK3 MAPK1
21 dendritic cell chemotaxis GO:0002407 9.7 CXCR2 CXCR1
22 engulfment of apoptotic cell GO:0043652 9.7 RAC2 RAC1
23 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.69 ITGB2 ICAM1
24 cellular response to dopamine GO:1903351 9.69 MAPK3 MAPK1
25 amyloid-beta clearance GO:0097242 9.69 ITGB2 ITGAM
26 regulation of ossification GO:0030278 9.68 MAPK3 MAPK1
27 neutrophil activation GO:0042119 9.68 CXCR2 CXCL8
28 regulation of stress-activated MAPK cascade GO:0032872 9.67 MAPK3 MAPK1
29 Bergmann glial cell differentiation GO:0060020 9.67 MAPK3 MAPK1
30 positive regulation of superoxide anion generation GO:0032930 9.67 ITGB2 ITGAM CD177
31 outer ear morphogenesis GO:0042473 9.66 MAPK3 MAPK1
32 regulation of early endosome to late endosome transport GO:2000641 9.66 MAPK3 MAPK1
33 acute inflammatory response to antigenic stimulus GO:0002438 9.65 ICAM1 CXCR2
34 positive regulation of macrophage proliferation GO:0120041 9.65 MAPK3 MAPK1
35 regulation of cellular pH GO:0030641 9.64 MAPK3 MAPK1
36 trachea formation GO:0060440 9.64 MAPK3 MAPK1
37 regulation of hydrogen peroxide metabolic process GO:0010310 9.63 RAC2 RAC1
38 regulation of neutrophil migration GO:1902622 9.62 RAC2 RAC1
39 caveolin-mediated endocytosis GO:0072584 9.62 MAPK3 MAPK1
40 leukocyte cell-cell adhesion GO:0007159 9.62 UMOD ITGB2 ICAM1 CD177
41 regulation of Golgi inheritance GO:0090170 9.61 MAPK3 MAPK1
42 response to epidermal growth factor GO:0070849 9.61 MAPK3 MAPK1
43 regulation of respiratory burst GO:0060263 9.6 RAC2 RAC1
44 negative regulation of dopamine metabolic process GO:0045963 9.59 ITGB2 ITGAM
45 positive regulation of prostaglandin-E synthase activity GO:2000363 9.58 ITGB2 ITGAM
46 cardiac neural crest cell development involved in heart development GO:0061308 9.58 MAPK3 MAPK1
47 interleukin-8-mediated signaling pathway GO:0038112 9.52 CXCR2 CXCR1
48 positive regulation of neutrophil chemotaxis GO:0090023 9.46 RAC2 RAC1 CXCR2 CXCL8
49 positive regulation of neutrophil degranulation GO:0043315 9.43 ITGB2 ITGAM CD177
50 chemotaxis GO:0006935 9.43 RAC2 RAC1 MAPK1 CXCR2 CXCR1 CXCL8

Molecular functions related to Neutrophil Migration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase activity GO:0004707 9.43 MAPK3 MAPK1
2 MAP kinase kinase activity GO:0004708 9.4 MAPK3 MAPK1
3 cargo receptor activity GO:0038024 9.37 ITGB2 ITGAM
4 C-X-C chemokine receptor activity GO:0016494 9.32 CXCR2 CXCR1
5 complement component C3b binding GO:0001851 9.26 ITGB2 ITGAM
6 interleukin-8 binding GO:0019959 9.16 CXCR2 CXCR1
7 integrin binding GO:0005178 9.02 MYH9 ITGB2 ITGAM ICAM1 CD177
8 interleukin-8 receptor activity GO:0004918 8.96 CXCR2 CXCR1

Sources for Neutrophil Migration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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