MCID: NTR042
MIFTS: 31

Neutrophilic Dermatosis, Acute Febrile

Categories: Rare diseases, Bone diseases, Skin diseases

Aliases & Classifications for Neutrophilic Dermatosis, Acute Febrile

MalaCards integrated aliases for Neutrophilic Dermatosis, Acute Febrile:

Name: Neutrophilic Dermatosis, Acute Febrile 57 53
Sweet Syndrome 57 76 53 59 73
Acute Febrile Neutrophilic Dermatosis 76 53 59
Ss 57 53
Acromelic Frontonasal Dysostosis 73
Gomm-Button Disease 57
Gomm Button Disease 53
Sweet Syndrome; Ss 57
Sweets Syndrome 55
Afnd 57

Characteristics:

Orphanet epidemiological data:

59
sweet syndrome
Prevalence: <1/1000000 (Worldwide); Age of onset: Adult;

Classifications:



External Ids:

OMIM 57 608068
Orphanet 59 ORPHA3243
ICD10 via Orphanet 34 L98.2
MESH via Orphanet 45 D016463
UMLS via Orphanet 74 C0085077
MedGen 42 C0085077

Summaries for Neutrophilic Dermatosis, Acute Febrile

NIH Rare Diseases : 53 Acute febrile neutrophilic dermatosis is a skin condition characterized by fever, inflammation of the joints (arthritis), and painful skin lesions that appear mainly on the face, neck, back and arms. Although middle-aged women are most likely to develop this condition, it may also affect men, older adults and even infants. The exact cause of acute febrile neutrophilic dermatosis often isn't known. It is suspected that it can be a reaction of the body to certain exposures (sun), infections (Streptococcus bacteria, Campylobacter), or medications (azathioprine, nonsteroidal anti-inflammatory medications). This condition can also occur with some types of cancer and other serious health problems. Most often, it isn't serious and will clear on its own in a few months. Healing is much more rapid; however, with treatment, such as corticosteroid use.

MalaCards based summary : Neutrophilic Dermatosis, Acute Febrile, also known as sweet syndrome, is related to acromelic frontonasal dysostosis and sickle cell anemia, and has symptoms including seizures An important gene associated with Neutrophilic Dermatosis, Acute Febrile is CSF3 (Colony Stimulating Factor 3). Affiliated tissues include neutrophil, skin and bone.

Wikipedia : 76 Sweet\'s syndrome (SS), or acute febrile neutrophilic dermatosis is a skin disease characterized by the... more...

Description from OMIM: 608068

Related Diseases for Neutrophilic Dermatosis, Acute Febrile

Diseases related to Neutrophilic Dermatosis, Acute Febrile via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 acromelic frontonasal dysostosis 11.8
2 sickle cell anemia 11.5
3 sjogren syndrome 11.2
4 majeed syndrome 11.1
5 hemoglobin se disease 11.1
6 frontonasal dysplasia 1 10.9
7 schimmelpenning-feuerstein-mims syndrome 10.9
8 fetal hemoglobin quantitative trait locus 5 10.9
9 serotonin syndrome 10.9
10 lupus erythematosus 10.4
11 leukemia 10.3
12 atrial standstill 1 10.3
13 systemic lupus erythematosus 10.3
14 heart block, congenital 10.2
15 myelodysplastic syndrome 10.2
16 adenocarcinoma 10.2
17 cutaneous lupus erythematosus 10.1
18 hairy cell leukemia 10.1
19 pyoderma gangrenosum 10.1
20 subacute cutaneous lupus erythematosus 10.1
21 annular erythema 9.9
22 sickle cell disease 9.9
23 premature ejaculation 9.9
24 sarcoma, synovial 9.9
25 arthritis 9.9
26 sarcoma 9.9
27 rheumatoid arthritis 9.8
28 neuromyelitis optica 9.8
29 hemoglobinopathy 9.8
30 hemochromatosis, neonatal 9.7
31 alpha-thalassemia 9.7
32 islet cell tumor 9.7
33 thalassemia 9.7
34 lymphoma 9.7
35 dermatomyositis 9.7
36 cortical blindness 9.7
37 optic neuritis 9.7
38 iritis 9.7
39 neuritis 9.7
40 central nervous system disease 9.7
41 retinitis 9.7
42 endophthalmitis 9.7
43 connective tissue disease 9.7
44 neuronitis 9.7
45 nervous system disease 9.7
46 vasculitis 9.7
47 igg4-related dacryoadenitis and sialadenitis 9.7
48 neuromyelitis optica spectrum disorder 9.7
49 polymyositis 9.7
50 endotheliitis 9.7

Graphical network of the top 20 diseases related to Neutrophilic Dermatosis, Acute Febrile:



Diseases related to Neutrophilic Dermatosis, Acute Febrile

Symptoms & Phenotypes for Neutrophilic Dermatosis, Acute Febrile

Clinical features from OMIM:

608068

UMLS symptoms related to Neutrophilic Dermatosis, Acute Febrile:


seizures

Drugs & Therapeutics for Neutrophilic Dermatosis, Acute Febrile

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275

Search NIH Clinical Center for Neutrophilic Dermatosis, Acute Febrile

Genetic Tests for Neutrophilic Dermatosis, Acute Febrile

Anatomical Context for Neutrophilic Dermatosis, Acute Febrile

MalaCards organs/tissues related to Neutrophilic Dermatosis, Acute Febrile:

41
Neutrophil, Skin, Bone, Thyroid, Lung

Publications for Neutrophilic Dermatosis, Acute Febrile

Articles related to Neutrophilic Dermatosis, Acute Febrile:

(show top 50) (show all 74)
# Title Authors Year
1
Sweet syndrome in patients with and without malignancy: A retrospective analysis of 83 patients from a tertiary academic referral center. ( 29107342 )
2018
2
Necrotizing Soft Tissue Infection or Sweet Syndrome: Surgery Versus No Surgery?: A Case Report. ( 28151765 )
2017
3
Sweet Syndrome Associated with Bilateral Nodular Scleritis. ( 29282197 )
2017
4
Aseptic Splenic Abscess and Sweet Syndrome. ( 27111793 )
2016
5
Aseptic meningitis and anti-I^2-glycoprotein 1 antibodies in Sweet syndrome. ( 27452622 )
2016
6
Histiocytoid Sweet syndrome with ophthalmologic involvements: A novel association with uveitis. ( 27177942 )
2016
7
Histiocytoid Sweet Syndrome Is More Frequently Associated With Myelodysplastic Syndromes Than the Classical Neutrophilic Variant: A Comparative Series of 62 Patients. ( 27082547 )
2016
8
Histiocytoid sweet syndrome: a novel association with relapsing polychondritis. ( 26474089 )
2015
9
Cutaneous infection with Mycobacterium kansasii in a patient with myelodysplastic syndrome and Sweet syndrome. ( 26244358 )
2015
10
[Neutrophilic dermatosis of the hands: acral sweet syndrome?]. ( 24612869 )
2015
11
An uncommon ocular manifestation of Sweet syndrome: peripheral ulcerative keratitis and nodular scleritis. ( 25714541 )
2015
12
Histiocytoid Sweet syndrome is infiltrated predominantly by M2-like macrophages. ( 25440433 )
2015
13
Acute febrile neutrophilic dermatosis (Sweet syndrome). ( 24953595 )
2014
14
Successful use of very low dose subcutaneous decitabine to treat high-risk myelofibrosis with Sweet syndrome that was refractory to 5-azacitidine. ( 23647061 )
2014
15
Orbital Lipomatosis: A Complication of Steroid Therapy in the Sweet Syndrome. ( 25120096 )
2014
16
An unusual case of Sweet syndrome in a child: overlapping presentation with erythema elevatum diutinum. ( 24521734 )
2014
17
Recurrence of abdominal large-vessel vasculitis and development of severe Sweet syndrome after a single cycle of 5-azacytidine in a patient with myelodysplastic syndrome. ( 24341928 )
2013
18
Histiocytoid Sweet syndrome and cutaneous polyarteritis nodosa secondary to myelodysplastic syndrome. ( 24382288 )
2013
19
Giant cellulitis-like Sweet Syndrome, a new variant of neutrophilic dermatosis. ( 23324762 )
2013
20
Sweet syndrome in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma: curious lymphocyte/neutrophil fluctuations. ( 24385834 )
2013
21
Sweet syndrome preceding a carcinoid lung tumor and multiple myeloma. ( 23961530 )
2013
22
Targetoid palmoplantar Sweet syndrome as presenting sign of severe Crohn's disease. ( 24034402 )
2013
23
Sweet syndrome following vemurafenib therapy for recurrent cholangiocarcinoma. ( 24372055 )
2013
24
Sweet syndrome associated with sporotrichosis. ( 21711340 )
2012
25
20q- clonality in a case of oral sweet syndrome and myelodysplasia. ( 22261459 )
2012
26
Minocycline-induced Sweet syndrome (acute febrile neutrophilic dermatosis). ( 23158645 )
2012
27
Sweet syndrome and pemphigus vulgaris. ( 22513066 )
2012
28
Necrotizing Sweet syndrome: a new variant of neutrophilic dermatosis mimicking necrotizing fasciitis. ( 22445215 )
2012
29
Sweet syndrome in an infant with chronic granulomatous disease. ( 22246153 )
2012
30
Sweet syndrome revealing microscopic polyangiitis. ( 22513149 )
2012
31
Autoimmune clustering: sweet syndrome, Hashimoto thyroiditis, and psoriasis. ( 21325961 )
2011
32
Optic nerve involvement with panuveitis in Sweet syndrome. ( 21595532 )
2011
33
Sweet syndrome, cutis laxa, and fatal cardiac manifestations in a 2-year-old girl. ( 21720474 )
2011
34
Paraneoplastic relapsing polychondritis and Sweet syndrome coexisting in a patient with myelodysplasia. ( 22016294 )
2011
35
Sweet syndrome as the presenting symptom of hairy cell leukemia. ( 19336029 )
2009
36
Bullous Sweet syndrome associated with an aseptic splenic abscess. ( 20099618 )
2009
37
Efficacy of anakinra, an IL1 receptor antagonist, in refractory Sweet syndrome. ( 18192308 )
2008
38
Ocular involvement in acute febrile neutrophilic dermatosis (Sweet syndrome): new cases and review of the literature. ( 18501268 )
2008
39
Sweet syndrome subsequent to relapsing polychondritis and myelodysplastic syndrome in a Japanese patient. ( 18779898 )
2008
40
Familial Mediterranean fever gene as a possible modifier of Sweet syndrome with chronic myelogenous leukemia. ( 18824843 )
2008
41
Sweet syndrome associated with granulocyte colony-stimulating factor. ( 18779624 )
2008
42
Sweet syndrome presenting as resistant conjunctivitis. ( 19034140 )
2008
43
Panniculitis with histiocytoid/immature neutrophils is not limited to histiocytoid panniculitic Sweet syndrome. ( 18032966 )
2007
44
Sweet syndrome associated with intrahepatic cholangiocarcinoma producing granulocyte colony-stimulating factor. ( 17034566 )
2006
45
The relationship between neutrophilic dermatosis of the dorsal hands and sweet syndrome: report of 9 cases and comparison to atypical pyoderma gangrenosum. ( 16415387 )
2006
46
A case of Sweet syndrome associated with human granulocytic anaplasmosis. ( 16027306 )
2005
47
Sweet syndrome (acute febrile neutrophilic dermatosis) associated with pulmonary coccidioidomycosis. ( 16027305 )
2005
48
A case of bilateral retinal vasculitis associated with Sweet syndrome. ( 16141877 )
2005
49
Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes. ( 16027297 )
2005
50
Refractory sweet syndrome with autoimmune organizing pneumonia treated with monoclonal antibodies to tumor necrosis factor. ( 17043542 )
2004

Variations for Neutrophilic Dermatosis, Acute Febrile

Expression for Neutrophilic Dermatosis, Acute Febrile

Search GEO for disease gene expression data for Neutrophilic Dermatosis, Acute Febrile.

Pathways for Neutrophilic Dermatosis, Acute Febrile

GO Terms for Neutrophilic Dermatosis, Acute Febrile

Sources for Neutrophilic Dermatosis, Acute Febrile

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