SS
MCID: NTR042
MIFTS: 33

Neutrophilic Dermatosis, Acute Febrile (SS)

Categories: Bone diseases, Rare diseases, Skin diseases

Aliases & Classifications for Neutrophilic Dermatosis, Acute Febrile

MalaCards integrated aliases for Neutrophilic Dermatosis, Acute Febrile:

Name: Neutrophilic Dermatosis, Acute Febrile 56 52
Sweet Syndrome 56 74 52 58 71
Acute Febrile Neutrophilic Dermatosis 74 52 58
Ss 56 52
Acromelic Frontonasal Dysostosis 71
Gomm-Button Disease 56
Gomm Button Disease 52
Sweet Syndrome; Ss 56
Sweets Syndrome 54
Afnd 56

Characteristics:

Orphanet epidemiological data:

58
sweet syndrome
Prevalence: <1/1000000 (Worldwide); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare skin diseases


External Ids:

OMIM 56 608068
MESH via Orphanet 44 D016463
ICD10 via Orphanet 33 L98.2
UMLS via Orphanet 72 C0085077
Orphanet 58 ORPHA3243
MedGen 41 C0085077
UMLS 71 C0085077 C1863616

Summaries for Neutrophilic Dermatosis, Acute Febrile

NIH Rare Diseases : 52 Acute febrile neutrophilic dermatosis is a skin condition characterized by fever, inflammation of the joints (arthritis ), and painful skin lesions that appear mainly on the face, neck, back and arms. Although middle-aged women are most likely to develop this condition, it may also affect men, older adults and even infants. The exact cause of acute febrile neutrophilic dermatosis often isn't known. It is suspected that it can be a reaction of the body to certain exposures (sun), infections (Streptococcus bacteria , C ampylobacter ), or medications (azathioprine , nonsteroidal anti-inflammatory medications ). This condition can also occur with some types of cancer and other serious health problems. Most often, it isn't serious and will clear on its own in a few months. Healing is much more rapid; however, with treatment, such as corticosteroid use.

MalaCards based summary : Neutrophilic Dermatosis, Acute Febrile, also known as sweet syndrome, is related to acromelic frontonasal dysostosis and sickle cell anemia, and has symptoms including seizures An important gene associated with Neutrophilic Dermatosis, Acute Febrile is CSF3 (Colony Stimulating Factor 3). The drugs sodium fluoride and Fluorides have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and myeloid.

Wikipedia : 74 Sweet's syndrome (SS), or acute febrile neutrophilic dermatosis is a skin disease characterized by the... more...

More information from OMIM: 608068

Related Diseases for Neutrophilic Dermatosis, Acute Febrile

Diseases related to Neutrophilic Dermatosis, Acute Febrile via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 540)
# Related Disease Score Top Affiliating Genes
1 acromelic frontonasal dysostosis 12.4
2 sickle cell anemia 12.0
3 sjogren syndrome 12.0
4 majeed syndrome 11.8
5 hemoglobin se disease 11.4
6 frontonasal dysplasia 1 11.3
7 schimmelpenning-feuerstein-mims syndrome 11.2
8 fetal hemoglobin quantitative trait locus 5 11.2
9 serotonin syndrome 11.2
10 heart block, congenital 10.5
11 sickle cell disease 10.5
12 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4
13 myelodysplastic syndrome 10.4
14 vasculitis 10.3
15 myeloproliferative neoplasm 10.3
16 exanthem 10.3
17 myeloid leukemia 10.2
18 dressler's syndrome 10.2
19 annular erythema 10.2
20 lupus erythematosus 10.2
21 thalassemia 10.2
22 crohn's disease 10.2
23 48,xyyy 10.2
24 leukemia 10.2
25 scleroderma, familial progressive 10.2
26 atrioventricular block 10.2
27 skin disease 10.1
28 keratoconjunctivitis sicca 10.1
29 inflammatory bowel disease 10.1
30 panniculitis 10.1
31 alpha-thalassemia 10.1
32 premature ejaculation 10.1
33 hemoglobinopathy 10.1
34 nervous system disease 10.1
35 autoimmune disease 10.1
36 systemic lupus erythematosus 10.1
37 myeloma, multiple 10.1
38 leukemia, acute myeloid 10.1
39 colitis 10.1
40 aseptic meningitis 10.1
41 neutropenia 10.1
42 cellulitis 10.1
43 ulcerative colitis 10.1
44 spondyloarthropathy 1 10.1
45 gastroesophageal reflux 10.1
46 down syndrome 10.1
47 suppression of tumorigenicity 12 10.1
48 aphasia 10.1
49 ileitis 10.1
50 blind loop syndrome 10.1

Graphical network of the top 20 diseases related to Neutrophilic Dermatosis, Acute Febrile:



Diseases related to Neutrophilic Dermatosis, Acute Febrile

Symptoms & Phenotypes for Neutrophilic Dermatosis, Acute Febrile

Clinical features from OMIM:

608068

UMLS symptoms related to Neutrophilic Dermatosis, Acute Febrile:


seizures

Drugs & Therapeutics for Neutrophilic Dermatosis, Acute Febrile

Drugs for Neutrophilic Dermatosis, Acute Febrile (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved 7681-49-4
2 Fluorides
3 Listerine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Assessment of the Enrichment of Rare Coding Genetic Variants in Patients Affected by Neutrophil-Mediated Inflammatory Dermatoses Recruiting NCT01952275
2 Chronic Recurrent Multifocal Osteomyelitis - Search for a Bacterial Cause and Improving Imaging With PET/MRI Recruiting NCT03433287

Search NIH Clinical Center for Neutrophilic Dermatosis, Acute Febrile

Genetic Tests for Neutrophilic Dermatosis, Acute Febrile

Anatomical Context for Neutrophilic Dermatosis, Acute Febrile

MalaCards organs/tissues related to Neutrophilic Dermatosis, Acute Febrile:

40
Neutrophil, Skin, Myeloid, T Cells, Bone, Lung, Breast

Publications for Neutrophilic Dermatosis, Acute Febrile

Articles related to Neutrophilic Dermatosis, Acute Febrile:

(show top 50) (show all 556)
# Title Authors PMID Year
1
Familial Sweet's syndrome in 2 brothers, both seen in the first 2 weeks of life. 56
12833027 2003
2
Sweet's syndrome (acute febrile neutrophilic dermatosis) 56
8089280 1994
3
Human leukocyte antigen in Sweet's syndrome and its relationship to Behçet's disease. 56
3389850 1988
4
Acute febrile neutrophilic dermatosis (Sweet's syndrome) in Behçet's disease. 56
3593637 1987
5
Diagnostic criteria for Sweet's syndrome. 56
3514153 1986
6
Acute febrile neutrophilic dermatosis. Sweet's syndrome. 56
5810898 1969
7
Recurrent neutrophilic dermatosis of the face--a variant of Sweet's syndrome. 56
5706799 1968
8
AN ACUTE FEBRILE NEUTROPHILIC DERMATOSIS. 56
14201182 1964
9
Sweet syndrome associated with granulocyte colony-stimulating factor. 54 61
18779624 2008
10
Sweet syndrome associated with intrahepatic cholangiocarcinoma producing granulocyte colony-stimulating factor. 54 61
17034566 2006
11
[Sweet syndrome following therapeutic use of granulocyte colony stimulating factor]. 54 61
10339998 1999
12
Sweet syndrome in a child with aplastic anemia receiving recombinant granulocyte colony-stimulating factor. 54 61
8689342 1996
13
Sweet syndrome associated with G-CSF treatment in a child with glycogen storage disease type Ib. 54 61
8604280 1996
14
Lymphoedema-area-restricted Sweet syndrome during G-CSF treatment. 54 61
8596402 1996
15
The Sweet syndrome or G-CSF reaction? 54 61
1384410 1992
16
The Sweet syndrome during therapy with granulocyte colony-stimulating factor. 54 61
1375012 1992
17
[A case of Sweet syndrome in a patient receiving erlotinib for lung adenocarcinoma]. 61
32029299 2020
18
Promyelocytic Differentiation in Infiltrates of Prurigo Pigmentosa: An Analogy to Histiocytoid Sweet Syndrome. 61
31995545 2020
19
Acquired cutis laxa secondary to Sweet syndrome in a child (Marshall syndrome): A rare case report. 61
31437319 2020
20
Tocilizumab-Induced Sweet Syndrome in a Patient With Polymyalgia Rheumatica. 61
31921506 2020
21
Type 2 leprosy reaction resembling Sweet syndrome: Review of new and published cases. 61
31984474 2020
22
Neutrophilic dermatosis of the dorsal hands (acral Sweet syndrome) with predominantly lymphocytic dermal infiltrate. 61
31596005 2020
23
Idiopathic histiocytoid Sweet syndrome with a butterfly rash-like appearance: A confusing case histologically mimicking rosacea-like dermatitis. 61
31553077 2020
24
Recurrent soft tissue inflammation, necrotizing fascitis or Sweet syndrome, diagnostic dilemma. 61
31893084 2019
25
[The 472nd case: dyspnea, pulmonary shadows, abnormalities of whole blood cells]. 61
31775462 2019
26
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease. 61
31254406 2019
27
[Acute generalized pustular bacterid followed by Sweet's syndrome and erythema nodosum]. 61
31812362 2019
28
A rare case of Sweet syndrome secondary to melioidosis. 61
31787085 2019
29
Histiocytoid Sweet syndrome recalcitrant to prednisone causing severe scarring. 61
31687458 2019
30
Cutaneous adult T-cell leukemia/lymphoma presenting as sweet syndrome. 61
31738645 2019
31
Histiocytoid Sweet syndrome. 61
31625142 2019
32
Neutrophilic Dermatosis of the Hands (Sweet Syndrome of the Hands) Associated With Rheumatoid Arthritis. 61
29258792 2019
33
A hydralazine-induced triumvirate: Lupus, cutaneous vasculitis, and cryptococcoid Sweet syndrome. 61
31720352 2019
34
JAAD Game Changers: Sweet syndrome in patients with and without malignancy: A retrospective analysis of 83 patients from a tertiary academic referral center. 61
31279034 2019
35
Drug-Induced Sweet Syndrome in a Man With Sarcoidosis: Are There Any Common Mechanisms of Pathogenesis? 61
29538086 2019
36
Sweet syndrome and erythema nodosum in a case of anal canal cancer during concomitant radiochemotherapy. 61
31617491 2019
37
Drug-Induced Sweet Syndrome. 61
31401061 2019
38
A Cross-Sectional Observational Study of Geriatric Dermatoses in a Tertiary Care Hospital of Northern India. 61
31544070 2019
39
Panniculitis in a 3-year-old child with Fanconi anemia-associated bone marrow hypoplasia heralds transformation to acute myeloid leukemia. 61
31318095 2019
40
Azathioprine-Induced Sweet Syndrome Treated With Infliximab. 61
30074533 2019
41
Proliferative Sweet syndrome associated with pregnancy and low-molecular-weight heparin sodium. 61
30907689 2019
42
Sweet syndrome in a patient with chronic myelogenous leukemia under dasatinib treatment. 61
30932238 2019
43
Neutrophilic dermatoses as adverse effects of checkpoint inhibitors: A review. 61
31444856 2019
44
Neutrophilic Dermatosis of the Dorsal Hands: A Review of 123 Cases. 61
31499154 2019
45
Dermatologic Urgencies and Emergencies: What Every Pathologist Should Know. 61
30785787 2019
46
Erythema Nodosum, Early Stage-A Subcutaneous Variant of Leukocytoclastic Vasculitis? Clinicopathological Correlation in a Series of 13 Patients. 61
31436577 2019
47
Sweet syndrome in metastatic melanoma during treatment with dabrafenib and trametinib. 61
30724336 2019
48
Superficial and Deep Cutaneous Involvement by RAS-Associated Autoimmunne Leukoproliferative Disease (RALD Cutis): A Histologic Mimicker of Histiocytoid Sweet Syndrome. 61
31335417 2019
49
Dapagliflozin-induced sweet syndrome. 61
31603973 2019
50
[Paraneoplastic skin diseases]. 61
31273399 2019

Variations for Neutrophilic Dermatosis, Acute Febrile

Expression for Neutrophilic Dermatosis, Acute Febrile

Search GEO for disease gene expression data for Neutrophilic Dermatosis, Acute Febrile.

Pathways for Neutrophilic Dermatosis, Acute Febrile

GO Terms for Neutrophilic Dermatosis, Acute Febrile

Sources for Neutrophilic Dermatosis, Acute Febrile

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
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31 HPO
32 ICD10
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37 LifeMap
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43 MeSH
44 MESH via Orphanet
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48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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