NC
MCID: NVS015
MIFTS: 42

Nevus Comedonicus (NC)

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Nevus Comedonicus

MalaCards integrated aliases for Nevus Comedonicus:

Name: Nevus Comedonicus 58 54 76 6 74
Nevus Comedonicus Syndrome 54 60
Nc 58 76
Nevus Comedonicus, Somatic 58
Comedone Naevus 54
Comedo Naevus 54

Characteristics:

Orphanet epidemiological data:

60
nevus comedonicus syndrome
Inheritance: Not applicable;

OMIM:

58
Inheritance:
somatic mutation


HPO:

33
nevus comedonicus:
Inheritance somatic mutation


Classifications:

Orphanet: 60  
Rare skin diseases


Summaries for Nevus Comedonicus

OMIM : 58 Nevus comedonicus (NC) is a rare type of epidermal nevus with predilection for the face and neck area. The condition develops within the first decade of life in most patients. NC is characterized by dilated, plugged follicular ostia containing lamellar keratinaceous material and grouped in a honeycomb pattern; the distribution of lesions may be unilateral, bilateral, linear, interrupted, segmental, or along the lines of Blaschko. NC may be nonpyogenic with an acne-like appearance or associated with the formation of cysts, papules, pustules, and abscesses. Histologically, the lesions are large, grouped, dilated follicular ostia devoid of hair shafts but filled with keratin layers (summary by Tchernev et al., 2013). (617025)

MalaCards based summary : Nevus Comedonicus, also known as nevus comedonicus syndrome, is related to skin disease and renal nutcracker syndrome. An important gene associated with Nevus Comedonicus is NEK9 (NIMA Related Kinase 9). Affiliated tissues include skin, prostate and t cells, and related phenotypes are hamartoma and comedo

UniProtKB/Swiss-Prot : 76 Nevus comedonicus: A rare type of epidermal nevus characterized by closely arranged, dilated, plugged follicular ostia in a honeycomb pattern. The plugged ostia contain lamellated keratinaceous material, and their appearance resembles black dots. NC may be non-pyogenic with an acne-like appearance or associated with the formation of cysts, papules, pustules, and abscesses. Most commonly it affects the face and neck area and, by exception, other anatomical regions, including genital area, palms, and soles. NC lesions might present with various patterns of distribution: unilateral, bilateral, linear, interrupted, segmental, or blaschkoid.

Wikipedia : 77 Nevus comedonicus (also known as a "comedo nevus") is characterized by closely arranged, grouped, often... more...

Related Diseases for Nevus Comedonicus

Diseases related to Nevus Comedonicus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 skin disease 28.9 ABCA12 FLG
2 renal nutcracker syndrome 11.3
3 x-linked charcot-marie-tooth disease 11.2
4 adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency 11.0
5 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 11.0
6 adrenal hyperplasia, congenital, due to steroid 11-beta-hydroxylase deficiency 11.0
7 adrenal hyperplasia, congenital, due to 17-alpha-hydroxylase deficiency 11.0
8 congenital myasthenic syndrome 11.0
9 dermatitis 11.0
10 dermatitis, atopic 11.0
11 epidermolytic hyperkeratosis 10.5
12 nevus, epidermal 10.2
13 tooth agenesis 10.2
14 asthma 10.2
15 human immunodeficiency virus type 1 10.2
16 sarcoma 10.1
17 atherosclerosis susceptibility 10.1
18 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 10.1
19 split-hand/foot malformation 1 10.1
20 ectodermal dysplasia 10.1
21 isolated split hand-split foot malformation 10.1
22 bladder cancer 10.1
23 breast cancer 10.1
24 epidermoid cysts 10.1
25 birt-hogg-dube syndrome 10.1
26 pulmonary alveolar microlithiasis 10.1
27 bone disease 10.1
28 hypothyroidism 10.1
29 keratosis 10.1
30 squamous cell carcinoma 10.1
31 hidradenitis suppurativa 10.1
32 hidradenitis 10.1
33 keratoacanthoma 10.1
34 hidradenoma 10.1
35 orofaciodigital syndrome 10.1
36 syringocystadenoma papilliferum 10.1
37 prostate cancer 10.1
38 prostate cancer, hereditary, 8 10.1
39 prostate cancer, hereditary, 6 10.1
40 carpal tunnel syndrome 10.0
41 rheumatoid arthritis 10.0
42 mononeuropathy of the median nerve, mild 10.0
43 rabies 10.0
44 dementia 10.0
45 dental caries 10.0
46 neuropathy 10.0
47 allergic asthma 10.0
48 polymyositis 10.0
49 neutrophil migration 9.9
50 cryohydrocytosis 9.9

Graphical network of the top 20 diseases related to Nevus Comedonicus:



Diseases related to Nevus Comedonicus

Symptoms & Phenotypes for Nevus Comedonicus

Human phenotypes related to Nevus Comedonicus:

60 33 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hamartoma 60 33 hallmark (90%) Very frequent (99-80%) HP:0010566
2 comedo 60 33 hallmark (90%) Very frequent (99-80%) HP:0025249
3 finger syndactyly 60 33 occasional (7.5%) Occasional (29-5%) HP:0006101
4 seizures 60 33 occasional (7.5%) Occasional (29-5%) HP:0001250
5 scoliosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002650
6 cataract 60 33 occasional (7.5%) Occasional (29-5%) HP:0000518
7 abnormal vertebral morphology 60 33 occasional (7.5%) Occasional (29-5%) HP:0003468
8 microcephaly 60 33 occasional (7.5%) Occasional (29-5%) HP:0000252
9 ichthyosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0008064
10 nevus flammeus 60 33 occasional (7.5%) Occasional (29-5%) HP:0001052
11 spina bifida occulta 60 33 occasional (7.5%) Occasional (29-5%) HP:0003298
12 toe syndactyly 60 33 occasional (7.5%) Occasional (29-5%) HP:0001770
13 preaxial polydactyly 60 33 occasional (7.5%) Occasional (29-5%) HP:0100258
14 abnormal hair morphology 33 occasional (7.5%) HP:0001595
15 abnormality of the foot 60 Occasional (29-5%)
16 spina bifida 60 Occasional (29-5%)
17 abnormality of the hair 60 Occasional (29-5%)

Symptoms via clinical synopsis from OMIM:

58
Skin Nails Hair Skin:
linearly grouped comedones
inflammatory cysts
cribriform scarring

Skin Nails Hair Skin Histology:
follicles with dilated ostia adjacent to normal follicles
marked acanthosis of outer root sheath in abnormal follicles
papillomatosis of outer root sheath in abnormal follicles
apparent lack of sebaceous lobules in abnormal follicles
large keratin-filled cysts in deep dermis

Clinical features from OMIM:

617025

Drugs & Therapeutics for Nevus Comedonicus

Search Clinical Trials , NIH Clinical Center for Nevus Comedonicus

Genetic Tests for Nevus Comedonicus

Anatomical Context for Nevus Comedonicus

MalaCards organs/tissues related to Nevus Comedonicus:

42
Skin, Prostate, T Cells, Liver, Brain, Kidney, Bone

Publications for Nevus Comedonicus

Articles related to Nevus Comedonicus:

(show top 50) (show all 1345)
# Title Authors Year
1
Effect of Resveratrol-Enriched Rice on Skin Inflammation and Pruritus in the NC/Nga Mouse Model of Atopic Dermatitis. ( 30901835 )
2019
2
Adipose-derived stem cells attenuate atopic dermatitis-like skin lesions in NC/Nga mice. ( 30688372 )
2019
3
Anti-Inflammatory Effect of Chloroform Fraction of Pyrus Ussuriensis Maxim. Leaf Extract on 2, 4-Dinitrochlorobenzene-Induced Atopic Dermatitis in nc/nga Mice. ( 30691219 )
2019
4
Ameliorative effects of green tea extract from tannase digests on house dust mite antigen-induced atopic dermatitis-like lesions in NC/Nga mice. ( 30617657 )
2019
5
Late-Onset Nevus Comedonicus With Follicular Epidermolytic Hyperkeratosis-Case Report and Review of the Literature. ( 30461425 )
2019
6
Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research. ( 30880305 )
2019
7
ER stress promotes antitumor effects in BRAFi/MEKi resistant human melanoma induced by natural compound 4-nerolidylcathecol (4-NC). ( 30550954 )
2019
8
A Microneedling Fractional Radiofrequency Device for the Treatment of Nevus Comedonicus. ( 30789510 )
2019
9
Late onset nevus comedonicus of scalp: a rare site for an uncommon condition. ( 30982310 )
2019
10
Hysteresis analysis of nitrate dynamics in the Neuse River, NC. ( 30380495 )
2019
11
EPAI-NC: Enhanced prediction of adenosine to inosine RNA editing sites using nucleotide compositions. ( 30664849 )
2019
12
Biodegradation of phenmedipham by novel Ochrobactrum anthropi NC-1. ( 30729076 )
2019
13
Conformer-specific [1,2]H-tunnelling in captodatively-stabilized cyanohydroxycarbene (NC-C[combining umlaut]-OH). ( 30774874 )
2019
14
Potential-driven surface active structure rearrangement over FeP@NC towards efficient electrocatalytic hydrogen evolution. ( 30916698 )
2019
15
Matrix Infrared Spectra and Electronic Structure Calculations of Linear Alkaline Earth Metal Di-isocyanides CNMNC, Ionic (NC)M(NC) Bowties, and Ionic (MNC)2 Rings. ( 30939012 )
2019
16
Human albumin augmented airway inflammation induced by PM2.5 in NC/Nga mice. ( 30953400 )
2019
17
Effect of Annealing on Surface Morphology and Wettability of NC-FeSi₂ Films Produced via Facing-Target Direct-Current Sputtering. ( 31027038 )
2019
18
Immune response profile of caruncular and trophoblast cell lines infected by high- (Nc-Spain7) and low-virulence (Nc-Spain1H) isolates of Neospora caninum. ( 31068227 )
2019
19
Spotlight on the Safety Net: NC Medical Schools Step Up Efforts to Address the Opioid Epidemic: Waiver Training for Students. ( 31072954 )
2019
20
Chlorination-Promoted Cage Transformation of IPR C92 Discovered via Trifluoromethylation under Formation of Non-classical C92 (NC)(CF3 )22. ( 31091007 )
2019
21
Asthma dissemination around patient-centered treatments in North Carolina (ADAPT-NC): a cluster randomized control trial evaluating dissemination of an evidence-based shared decision-making intervention for asthma management. ( 30252544 )
2018
22
Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model. ( 30297827 )
2018
23
Ag-carried CMC/functional copolymer/ODA-Mt wLED-treated NC and their responses to brain cancer cells. ( 30184772 )
2018
24
Signs of atopic dermatitis and contact dermatitis affected by distinct H2-haplotype in the NC/Nga genetic background. ( 29416104 )
2018
25
Supplemental feeding of phospholipid-enriched alkyl phospholipid from krill relieves spontaneous atopic dermatitis and strengthens skin intercellular lipid barriers in NC/Nga mice. ( 30572792 )
2018
26
Basidiomycetes-X, an edible mushroom, alleviates the development of atopic dermatitis in NC/Nga mouse model. ( 30312598 )
2018
27
Topical administration of EGF suppresses immune response and protects skin barrier in DNCB-induced atopic dermatitis in NC/Nga mice. ( 30093649 )
2018
28
Pyrus ussuriensis Maxim. leaves extract ameliorates DNCB-induced atopic dermatitis-like symptoms in NC/Nga mice. ( 30195883 )
2018
29
Irradiation with 310 nm and 340 nm ultraviolet light-emitting-diodes can improve atopic dermatitis-like skin lesions in NC/Nga mice. ( 30019049 )
2018
30
The Clock Genes Are Involved in The Deterioration of Atopic Dermatitis after Day-and-Night Reversed Physical Stress in NC/Nga Mice. ( 30069250 )
2018
31
Costaria costata Extract Suppresses Development of Atopic Dermatitis in chloro-2,4-dinitrobenzene-treated NC/Nga Mice. ( 29791915 )
2018
32
Epidermal Growth Factor Relieves Inflammatory Signals in Staphylococcus aureus-Treated Human Epidermal Keratinocytes and Atopic Dermatitis-Like Skin Lesions in Nc/Nga Mice. ( 29862299 )
2018
33
Bleomycin Aggravates Atopic Dermatitis via Lung Inflammation in 2,4-Dinitrochlorobenzene-Induced NC/Nga Mice. ( 29910732 )
2018
34
The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice. ( 29669333 )
2018
35
Effect of administrating polysaccharide from black currant (Ribes nigrum L.) on atopic dermatitis in NC/Nga mice. ( 29387518 )
2018
36
Pinus densiflora bark extract ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice by regulating Th1/Th2 balance and skin barrier function. ( 29484729 )
2018
37
Substance P restores normal skin architecture and reduces epidermal infiltration of sensory nerve fiber in TNCB-induced atopic dermatitis-like lesions in NC/Nga mice. ( 29269174 )
2018
38
Ultraviolet B eye irradiation aggravates atopic dermatitis via adrenocorticotropic hormone and NLRP3 inflammasome in NC/Nga mice. ( 29235163 )
2018
39
Ultraviolet A Eye Irradiation Ameliorates Atopic Dermatitis via p53 and Clock Gene Proteins in NC/Nga Mice. ( 29105092 )
2018
40
The prevention of TNF-α/IFN-γ mixture-induced inflammation in human keratinocyte and atopic dermatitis-like skin lesions in Nc/Nga mice by mineral-balanced deep sea water. ( 29156522 )
2018
41
Manifestation of atopic dermatitis-like skin in TNCB-induced NC/Nga mice is ameliorated by topical treatment of substance P, possibly through blockade of allergic inflammation. ( 28833499 )
2018
42
Difference in normal limit values of nerve conduction parameters between Westerners and Japanese people might need to be considered when diagnosing diabetic polyneuropathy using a Point-of-Care Sural Nerve Conduction Device (NC-stat®/DPNCheck™). ( 29430866 )
2018
43
Congenital nevus comedonicus complicated by a hidradenitis suppurativa-like lesion: Report of a childhood case. ( 29952017 )
2018
44
Mutation and expression of ABCA12 in keratosis pilaris and nevus comedonicus. ( 30066947 )
2018
45
Nevus Comedonicus on Scalp: An Unusual Presentation. ( 29440859 )
2018
46
Extensive Nevus Comedonicus, Complicated with Recurrent Abscesses, Successfully Treated with Surgical Resurfacing. ( 29731591 )
2018
47
In Situ Antisolvent Approach to Hydrangea-like HCo3 O4 -NC@CoNi-LDH Core@Shell Superstructures for Highly Efficient Water Electrolysis. ( 28950042 )
2018
48
Phase Ib/II Trial of NC-6004 (Nanoparticle Cisplatin) Plus Gemcitabine in Patients with Advanced Solid Tumors. ( 29030354 )
2018
49
HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1. ( 29127210 )
2018
50
Physiological effects of brominated flame retardants on NC/Nga mice. ( 29219636 )
2018

Variations for Nevus Comedonicus

UniProtKB/Swiss-Prot genetic disease variations for Nevus Comedonicus:

76
# Symbol AA change Variation ID SNP ID
1 NEK9 p.Ile167Thr VAR_077801 rs879253775
2 NEK9 p.Ile573Thr VAR_077802

ClinVar genetic disease variations for Nevus Comedonicus:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NEK9 NM_033116.5(NEK9): c.1715G> T (p.Gly572Val) single nucleotide variant no interpretation for the single variant rs886037839 GRCh38 Chromosome 14, 75103858: 75103858
2 NEK9 NM_033116.5(NEK9): c.1715G> T (p.Gly572Val) single nucleotide variant no interpretation for the single variant rs886037839 GRCh37 Chromosome 14, 75570561: 75570561
3 NEK9 NM_033116.4(NEK9): c.1817T> C (p.Ile573Thr) single nucleotide variant Pathogenic rs1555352529 GRCh38 Chromosome 14, 75103855: 75103855
4 NEK9 NM_033116.4(NEK9): c.1817T> C (p.Ile573Thr) single nucleotide variant Pathogenic rs1555352529 GRCh37 Chromosome 14, 75570558: 75570558
5 NEK9 NM_033116.5(NEK9): c.500T> C (p.Ile167Thr) single nucleotide variant Pathogenic rs879253775 GRCh37 Chromosome 14, 75587237: 75587237
6 NEK9 NM_033116.5(NEK9): c.500T> C (p.Ile167Thr) single nucleotide variant Pathogenic rs879253775 GRCh38 Chromosome 14, 75120534: 75120534
7 NEK9 NM_033116.5(NEK9): c.1731+1G> T single nucleotide variant no interpretation for the single variant rs886037838 GRCh38 Chromosome 14, 75103841: 75103841
8 NEK9 NM_033116.5(NEK9): c.1731+1G> T single nucleotide variant no interpretation for the single variant rs886037838 GRCh37 Chromosome 14, 75570544: 75570544

Expression for Nevus Comedonicus

Search GEO for disease gene expression data for Nevus Comedonicus.

Pathways for Nevus Comedonicus

GO Terms for Nevus Comedonicus

Biological processes related to Nevus Comedonicus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinocyte differentiation GO:0030216 8.96 ABCA12 FLG
2 establishment of skin barrier GO:0061436 8.62 ABCA12 FLG

Sources for Nevus Comedonicus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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