MCID: NVS007
MIFTS: 33

Nevus of Ota

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Nevus of Ota

MalaCards integrated aliases for Nevus of Ota:

Name: Nevus of Ota 59 17
Nevus Fusculoceruleus Ophthalmomaxillaris 59

Characteristics:

Orphanet epidemiological data:

59
nevus of ota
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

ICD10 via Orphanet 34 D22.3
UMLS via Orphanet 73 C0027961
Orphanet 59 ORPHA263425

Summaries for Nevus of Ota

MalaCards based summary : Nevus of Ota, also known as nevus fusculoceruleus ophthalmomaxillaris, is related to melanoma, uveal and skin melanoma. An important gene associated with Nevus of Ota is BAP1 (BRCA1 Associated Protein 1), and among its related pathways/superpathways are DNA Double Strand Break Response and Proteoglycans in cancer. Affiliated tissues include skin, eye and brain, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and digestive/alimentary

Wikipedia : 75 Nevus of Ota (also known as "congenital melanosis bulbi", "nevus fuscoceruleus ophthalmomaxillaris",... more...

Related Diseases for Nevus of Ota

Diseases related to Nevus of Ota via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 melanoma, uveal 30.0 BRAF BAP1
2 skin melanoma 30.0 TP53 BRAF
3 phacomatosis pigmentovascularis 11.8
4 dowling-degos disease 1 10.8
5 melanoma 10.7
6 tièche-jadassohn nevus 10.6
7 meningeal melanocytoma 10.5
8 intraocular pressure quantitative trait locus 10.5
9 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.4
10 hemangioma 10.4
11 open-angle glaucoma 10.3
12 mongolian spot 10.3
13 exophthalmos 10.3
14 meningeal melanoma 10.3
15 malignant choroid melanoma 10.3
16 hard palate cancer 10.3
17 neurofibromatosis, type iv, of riccardi 10.2
18 sturge-weber syndrome 10.2
19 branchiootic syndrome 1 10.2
20 meningioma, radiation-induced 10.2
21 meningioma, familial 10.2
22 spinal meningioma 10.2
23 neurilemmoma 10.2
24 secretory meningioma 10.2
25 lymphoplasmacyte-rich meningioma 10.2
26 cataract 10.2
27 47,xyy 10.2
28 weber syndrome 10.2
29 neurofibromatosis, type ii 10.0
30 anisocoria 10.0
31 epidermoid cysts 10.0
32 klippel-trenaunay-weber syndrome 10.0
33 lentigines 10.0
34 lipomatosis, multiple 10.0
35 nevus anemicus 10.0
36 scleroderma, familial progressive 10.0
37 spinocerebellar ataxia 2 10.0
38 vitiligo-associated multiple autoimmune disease susceptibility 6 10.0
39 cutis marmorata telangiectatica congenita 10.0
40 melanosis, neurocutaneous 10.0
41 retinitis pigmentosa 10.0
42 yemenite deaf-blind hypopigmentation syndrome 10.0
43 vitiligo-associated multiple autoimmune disease susceptibility 1 10.0
44 carney complex variant 10.0
45 paraganglioma 10.0
46 ptosis 10.0
47 neuroretinitis 10.0
48 pleomorphic lipoma 10.0
49 arteriovenous malformation 10.0
50 acoustic neuroma 10.0

Symptoms & Phenotypes for Nevus of Ota

GenomeRNAi Phenotypes related to Nevus of Ota according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.8 BAP1 BRAF TP53

MGI Mouse Phenotypes related to Nevus of Ota:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 BAP1 BRAF TP53
2 muscle MP:0005369 9.33 BAP1 BRAF TP53
3 neoplasm MP:0002006 9.13 BAP1 BRAF TP53
4 respiratory system MP:0005388 8.8 BAP1 BRAF TP53

Drugs & Therapeutics for Nevus of Ota

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Comparison of Picosecond 532 and 1,064 Nanometers Laser and Q-switched Nd:YAG 532 and 1,064 Nanometers Laser in the Treatment of Benign Pigmented Lesions: A Randomized Controlled Trial Unknown status NCT02800525 Phase 4
2 Optical Clearing of the Skin in Conjunction With Laser Treatments Completed NCT00580736 Phase 1
3 Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following a Q-Switched Nd:YAG Laser Treatment of Acquired Bilateral Nevus of Ota-Like Macules Completed NCT00287001

Search NIH Clinical Center for Nevus of Ota

Genetic Tests for Nevus of Ota

Anatomical Context for Nevus of Ota

MalaCards organs/tissues related to Nevus of Ota:

41
Skin, Eye, Brain, Pineal

Publications for Nevus of Ota

Articles related to Nevus of Ota:

(show top 50) (show all 347)
# Title Authors PMID Year
1
Clinical characteristics and treatment of 52 cases of phakomatosis pigmentovascularis. 38
31389056 2019
2
Clinical and genetic characteristics of nevus of Ota with choroidal melanoma in Chinese. 38
31407624 2019
3
Correction to: Nevus of Ota - an intraoral presentation: a case report. 38
31391114 2019
4
Nevus of Ota, a classic presentation. 38
30591278 2019
5
Meningeal Melanocytoma Associated with Nevus of Ota: Analysis of Twelve Reported Cases. 38
30904806 2019
6
Glaucoma in Phacomatosis Pigmentovascularis in a Young African Adolescent Boy: A Case Report. 38
30994485 2019
7
GNAQ and PMS1 Mutations Associated with Uveal Melanoma, Ocular Surface Melanosis, and Nevus of Ota. 38
31367589 2019
8
Nevus of Ota - an intraoral presentation: a case report. 38
31171040 2019
9
Oculodermal Melanocytosis: Nevus of Ota in a Dog. 38
30686121 2019
10
Phakomatosis Pigmentovascularis: A Clinical Profile of 11 Indian Patients. 38
31148861 2019
11
Variables that predict response of nevus of ota to lasers. 38
30723997 2019
12
Comparison of a picosecond alexandrite laser versus a Q-switched alexandrite laser for the treatment of nevus of Ota: A randomized, split-lesion, controlled trial. 38
30885760 2019
13
Characteristics and management of Asian skin. 38
30039861 2019
14
Optimizing Q-switched lasers for melasma and acquired dermal melanoses. 38
30027914 2019
15
Usefulness of picosecond pulse alexandrite laser treatment for nevus of Ota. 38
31182899 2018
16
Treatment of flat and elevated pigmented disorders with a 755-nm alexandrite picosecond laser: clinical and histological evaluation. 38
29423841 2018
17
A retrospective analysis of the clinical efficacies and recurrence of Q-switched Nd:YAG laser treatment of nevus of Ota in 224 Chinese patients. 38
29521541 2018
18
Picosecond Laser Treatment for Acquired Bilateral Nevus of Ota-like Macules. 38
30208473 2018
19
Nevus of Ota associated with a primary uveal melanoma and intracranial melanoma metastasis. 38
30372724 2018
20
A split-face, single-blinded, randomized controlled comparison of alexandrite 755-nm picosecond laser versus alexandrite 755-nm nanosecond laser in the treatment of acquired bilateral nevus of Ota-like macules. 38
29288102 2018
21
Classification of non-tumorous skin pigmentation disorders using voting based probabilistic linear discriminant analysis. 38
29909227 2018
22
Port-wine stain as a clue for two rare coexisting entities. 38
30007908 2018
23
Orbital melanocytoma: When a tumor becomes a relieving surprise. 38
29687085 2018
24
Examination of the melanocytes of the Nevus of Ota with in vivo reflectance confocal microscopy: 15 cases. 38
29314292 2018
25
Nevus of Ota (oculodermal melanocytosis) in a dog. 38
28745006 2018
26
[Supratentorial Meningeal Melanoma with Nevus of Ota:A Case Report]. 38
29449519 2018
27
Primary meningeal melanocytoma of the cerebellopontine angle associated with ipsilateral nevus of Ota: A case report. 38
30613434 2018
28
Successful and safe use of Q-switched lasers in the treatment of nevus of Ota in children with phototypes IV-VI. 38
29131366 2018
29
A study on the clinical characteristics of treating nevus of Ota by Q-switched Nd:YAG laser. 38
28986651 2018
30
Clinical profile and triggering factors for acquired, bilateral nevus of Ota-like macules. 38
28122465 2017
31
Clinical profile of 300 men with facial hypermelanosis. 38
29367869 2017
32
[Vitiligo occurring on dermal melanocytosis (nevus of Ota) in a dark-skinned patient]. 38
28728861 2017
33
Erratum: Treatment and Classification of Nevus of Ota: A Seven-Year Review of a Single Institution's Experience. 38
28932095 2017
34
Laser treatment of medical skin disease in women. 38
28831422 2017
35
Treatment and Classification of Nevus of Ota: A Seven-Year Review of a Single Institution's Experience. 38
28761293 2017
36
A Novel Surgical Approach for Oculodermal Melanocytosis: Superficial Sclerectomy. 38
27058831 2017
37
A split-face comparison of Q-switched Nd:YAG 1064-nm laser for facial rejuvenation in Nevus of Ota patients. 38
28299489 2017
38
Ocular Features in a Case of Nevus of Ota. 38
28302248 2017
39
Phakomatosis pigmentovascularis type IIb: A case with Klippel-Trenáunay syndrome and extensive dermal melanocytosis as nevus of Ota, nevus of Ito and ectopic Mongolian spots. 38
27374914 2017
40
Prof. Masao Ota. 38
28855482 2017
41
Recurrence of Nevus of Ota after Successful Laser Treatment: Possible Role of Dermal Stem Cells. 38
27746651 2016
42
The use of picosecond lasers beyond tattoos. 38
27183360 2016
43
Uveal Melanoma Cell Lines: Where do they come from? (An American Ophthalmological Society Thesis). 38
28018010 2016
44
An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota. 38
27699140 2016
45
Primary Melanoma of the Leptomeninges with BAP1 Expression-Loss in the Setting of a Nevus of Ota: A Clinical, Morphological and Genetic Study of 2 Cases. 38
26834043 2016
46
Three cases of symmetrical nevus of Ota and a brief literature review. 38
26889643 2016
47
Induction of melasma by 1064-nm Q-switched neodymium:yttrium-aluminum-garnet laser therapy for acquired bilateral nevus of Ota-like macules (Hori nevus): A study on related factors in the Chinese population. 38
26777390 2016
48
Picosecond pulse duration laser treatment for dermal melanocytosis in Asians : A retrospective review. 38
27721561 2016
49
A Retrospective Study on the Characteristics of Treating Nevus of Ota by 1064-nm Q-switched Neodymium-doped Yttrium Aluminum Garnet Laser. 38
27293272 2016
50
Nevus of Ota. 38
27734644 2016

Variations for Nevus of Ota

Expression for Nevus of Ota

Search GEO for disease gene expression data for Nevus of Ota.

Pathways for Nevus of Ota

GO Terms for Nevus of Ota

Cellular components related to Nevus of Ota according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 8.32 BAP1

Biological processes related to Nevus of Ota according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein deubiquitination GO:0016579 8.96 TP53 BAP1
2 cellular response to drug GO:0035690 8.62 TP53 BRAF

Sources for Nevus of Ota

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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