MCID: NVS007
MIFTS: 35

Nevus of Ota

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Nevus of Ota

MalaCards integrated aliases for Nevus of Ota:

Name: Nevus of Ota 60 17
Nevus Fusculoceruleus Ophthalmomaxillaris 60

Characteristics:

Orphanet epidemiological data:

60
nevus of ota
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

ICD10 via Orphanet 35 D22.3
UMLS via Orphanet 75 C0027961
Orphanet 60 ORPHA263425

Summaries for Nevus of Ota

MalaCards based summary : Nevus of Ota, also known as nevus fusculoceruleus ophthalmomaxillaris, is related to melanoma, uveal and phacomatosis pigmentovascularis. An important gene associated with Nevus of Ota is BAP1 (BRCA1 Associated Protein 1), and among its related pathways/superpathways are DNA Double Strand Break Response and Proteoglycans in cancer. Affiliated tissues include eye, skin and brain, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and digestive/alimentary

Wikipedia : 77 Nevus of Ota (also known as "congenital melanosis bulbi", "nevus fuscoceruleus ophthalmomaxillaris",... more...

Related Diseases for Nevus of Ota

Diseases related to Nevus of Ota via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 melanoma, uveal 29.7 BAP1 BRAF
2 phacomatosis pigmentovascularis 11.6
3 melanoma 10.7
4 meningeal melanocytoma 10.5
5 neutrophil migration 10.5
6 tièche-jadassohn nevus 10.5
7 klippel-trenaunay-weber syndrome 10.2
8 cataract 10.2
9 open-angle glaucoma 10.2
10 mongolian spot 10.2
11 meningeal melanoma 10.2
12 lentigines 10.0
13 nevus anemicus 10.0
14 sturge-weber syndrome 10.0
15 cutis marmorata telangiectatica congenita 10.0
16 glaucoma 3, primary congenital, a 10.0
17 retinitis pigmentosa 10.0
18 leber congenital amaurosis 4 10.0
19 hemorrhage, intracerebral 10.0
20 melanoma metastasis 10.0
21 arteriovenous malformation 10.0
22 leopard syndrome 10.0
23 neurilemmoma 10.0
24 retinitis 10.0
25 malignant choroid melanoma 10.0
26 hard palate cancer 10.0
27 noonan syndrome with multiple lentigines 10.0
28 cerebellar degeneration 10.0
29 weber syndrome 10.0
30 clear cell renal cell carcinoma 9.9 BAP1 TP53
31 bladder squamous cell carcinoma 9.9 BRAF TP53
32 hyperplastic polyposis syndrome 9.9 BRAF TP53
33 spitz nevus 9.9 BRAF TP53
34 mature teratoma 9.9 BRAF TP53
35 pleomorphic xanthoastrocytoma 9.9 BRAF TP53
36 giant cell glioblastoma 9.9 BRAF TP53
37 ganglioglioma 9.9 BRAF TP53
38 brain stem glioma 9.9 BRAF TP53
39 skin melanoma 9.9 BRAF TP53
40 ovarian serous cystadenocarcinoma 9.9 BRAF TP53
41 adenocarcinoma 9.9 BRAF TP53
42 leukemia, chronic lymphocytic 2 9.9 BRAF TP53
43 colorectal adenocarcinoma 9.9 BRAF TP53
44 testicular germ cell tumor 9.9 BRAF TP53
45 differentiated thyroid carcinoma 9.9 BRAF TP53
46 renal cell carcinoma, papillary, 1 9.9 BRAF TP53
47 suppression of tumorigenicity 12 9.8 BRAF TP53
48 rhabdoid meningioma 9.8 BAP1 BRAF
49 transitional cell carcinoma 9.8 BRAF TP53
50 adrenocortical carcinoma, hereditary 9.8 BRAF TP53

Graphical network of the top 20 diseases related to Nevus of Ota:



Diseases related to Nevus of Ota

Symptoms & Phenotypes for Nevus of Ota

GenomeRNAi Phenotypes related to Nevus of Ota according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.8 BAP1 BRAF TP53

MGI Mouse Phenotypes related to Nevus of Ota:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 BAP1 BRAF TP53
2 muscle MP:0005369 9.33 BAP1 BRAF TP53
3 neoplasm MP:0002006 9.13 BAP1 BRAF TP53
4 respiratory system MP:0005388 8.8 BAP1 BRAF TP53

Drugs & Therapeutics for Nevus of Ota

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optical Clearing of the Skin in Conjunction With Laser Treatments Completed NCT00580736 Phase 1
2 Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following Laser Treatment Completed NCT00287001 Not Applicable

Search NIH Clinical Center for Nevus of Ota

Genetic Tests for Nevus of Ota

Anatomical Context for Nevus of Ota

MalaCards organs/tissues related to Nevus of Ota:

42
Eye, Skin, Brain, Pineal, Bone, Thyroid, Neutrophil

Publications for Nevus of Ota

Articles related to Nevus of Ota:

(show top 50) (show all 209)
# Title Authors Year
1
Meningeal melanocytoma associated with nevus of Ota: An analysis of 12 cases. ( 30904806 )
2019
2
Oculodermal Melanocytosis: Nevus of Ota in a Dog. ( 30686121 )
2019
3
Variables that predict response of nevus of ota to lasers. ( 30723997 )
2019
4
Comparison of a picosecond alexandrite laser versus a Q-switched alexandrite laser for the treatment of nevus of Ota: A randomized, split-lesion, controlled trial. ( 30885760 )
2019
5
Nevus of Ota associated with a primary uveal melanoma and intracranial melanoma metastasis. ( 30372724 )
2018
6
Primary meningeal melanocytoma of the cerebellopontine angle associated with ipsilateral nevus of Ota: A case report. ( 30613434 )
2018
7
Nevus of Ota (oculodermal melanocytosis) in a dog. ( 28745006 )
2018
8
A study on the clinical characteristics of treating nevus of Ota by Q-switched Nd:YAG laser. ( 28986651 )
2018
9
Successful and safe use of Q-switched lasers in the treatment of nevus of Ota in children with phototypes IV-VI. ( 29131366 )
2018
10
A split-face, single-blinded, randomized controlled comparison of alexandrite 755-nm picosecond laser versus alexandrite 755-nm nanosecond laser in the treatment of acquired bilateral nevus of Ota-like macules. ( 29288102 )
2018
11
Examination of the melanocytes of the Nevus of Ota with in vivo reflectance confocal microscopy: 15 cases. ( 29314292 )
2018
12
A retrospective analysis of the clinical efficacies and recurrence of Q-switched Nd:YAG laser treatment of nevus of Ota in 224 Chinese patients. ( 29521541 )
2018
13
Picosecond Laser Treatment for Acquired Bilateral Nevus of Ota-like Macules. ( 30208473 )
2018
14
Nevus of Ota, a classic presentation. ( 30591278 )
2018
15
Phakomatosis pigmentovascularis type IIb: A case with Klippel-Trenáunay syndrome and extensive dermal melanocytosis as nevus of Ota, nevus of Ito and ectopic Mongolian spots. ( 27374914 )
2017
16
Clinical profile and triggering factors for acquired, bilateral nevus of Ota-like macules. ( 28122465 )
2017
17
A split-face comparison of Q-switched Nd:YAG 1064-nm laser for facial rejuvenation in Nevus of Ota patients. ( 28299489 )
2017
18
Ocular Features in a Case of Nevus of Ota. ( 28302248 )
2017
19
Treatment and Classification of Nevus of Ota: A Seven-Year Review of a Single Institution's Experience. ( 28761293 )
2017
20
Erratum: Treatment and Classification of Nevus of Ota: A Seven-Year Review of a Single Institution's Experience. ( 28932095 )
2017
21
Factors affecting response, number of laser sessions and complications in nevus of Ota treated by Q-switched alexandrite laser: a retrospective study. ( 25747257 )
2016
22
A randomized, split-face clinical trial of Q-switched alexandrite laser versus Q-switched Nd:YAG laser in the treatment of bilateral nevus of Ota. ( 25968166 )
2016
23
Lasers and nevus of Ota: a comprehensive review. ( 26563954 )
2016
24
Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations. ( 26701415 )
2016
25
Induction of melasma by 1064-nm Q-switched neodymium:yttrium-aluminum-garnet laser therapy for acquired bilateral nevus of Ota-like macules (Hori nevus): A study on related factors in the Chinese population. ( 26777390 )
2016
26
Analysis of 28 Chinese Cases of Bilateral Nevus of Ota and Therapeutic Results With the Q-Switched Alexandrite Laser. ( 26808181 )
2016
27
Primary Melanoma of the Leptomeninges with BAP1 Expression-Loss in the Setting of a Nevus of Ota: A Clinical, Morphological and Genetic Study of 2 Cases. ( 26834043 )
2016
28
Comparison of clinical efficacy and complications between Q-switched alexandrite laser and Q-switched Nd:YAG laser on nevus of Ota: a systematic review and meta-analysis. ( 26861980 )
2016
29
Three cases of symmetrical nevus of Ota and a brief literature review. ( 26889643 )
2016
30
A Retrospective Study on the Characteristics of Treating Nevus of Ota by 1064-nm Q-switched Neodymium-doped Yttrium Aluminum Garnet Laser. ( 27293272 )
2016
31
An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota. ( 27699140 )
2016
32
Nevus of Ota. ( 27734644 )
2016
33
Recurrence of Nevus of Ota after Successful Laser Treatment: Possible Role of Dermal Stem Cells. ( 27746651 )
2016
34
The case of a boy with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita: a unique instance of phacomatosis pigmentovascularis. ( 26312661 )
2015
35
Intermediate-grade meningeal melanocytoma associated with nevus of Ota: a case report and review of the literature. ( 25933209 )
2015
36
Cerebellar meningeal melanocytoma associated with nevus of Ota: An extremely rare case. ( 26259856 )
2015
37
Beneficial effects of early treatment of nevus of Ota with low-fluence 1,064-nm Q-switched Nd:YAG laser. ( 25485806 )
2015
38
Treatment of nevus of ota with a picosecond 755-nm alexandrite laser. ( 25760558 )
2015
39
Giant Blue Nevus: A New Association to Nevus of Ota. ( 26121271 )
2015
40
Giant nevus of Ota. ( 26265645 )
2015
41
Nevus of Ota/oculodermal melancytosis: a rare report of an oral mucosal lesion involving the hard palate. ( 26682294 )
2015
42
A retrospective analysis of the clinical efficacies of Q-switched Alexandrite and Q-switched Nd:YAG lasers in the treatment of nevus of Ota in Korean patients. ( 24888365 )
2015
43
Orbital melanocytoma completely resected with conservative surgery in association with ipsilateral nevus of Ota: report of a case and review of the literature. ( 24989678 )
2015
44
Bilateral familial nevus of Ota. ( 25448143 )
2014
45
Centrally located acquired bilateral nevus of ota-like macules: a bizarre pattern. ( 25823087 )
2014
46
Treatment of nevus of Ota using low fluence Q-switched Nd:YAG laser. ( 23834371 )
2014
47
BRAF V600E mutation in two distinct meningeal melanocytomas associated with a nevus of Ota. ( 24493731 )
2014
48
A retrospective study on laser treatment of nevus of Ota in Chinese children--a seven-year follow-up. ( 24684590 )
2014
49
Animal-type malignant melanoma associated with nevus of Ota in the orbit of a Japanese woman: a case report. ( 24686419 )
2014
50
Acquired Bilateral Nevus of ota-like Macules with Mucosal Involvement: A New Variant of Hori's Nevus. ( 24891664 )
2014

Variations for Nevus of Ota

Expression for Nevus of Ota

Search GEO for disease gene expression data for Nevus of Ota.

Pathways for Nevus of Ota

GO Terms for Nevus of Ota

Cellular components related to Nevus of Ota according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 8.32 BAP1

Biological processes related to Nevus of Ota according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein deubiquitination GO:0016579 8.96 BAP1 TP53
2 cellular response to drug GO:0035690 8.62 BRAF TP53

Sources for Nevus of Ota

3 CDC
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11 DGIdb
17 EFO
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20 FMA
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33 HPO
34 ICD10
35 ICD10 via Orphanet
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38 KEGG
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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