MCID: NVS007
MIFTS: 35

Nevus of Ota

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Nevus of Ota

MalaCards integrated aliases for Nevus of Ota:

Name: Nevus of Ota 59
Nevus Fusculoceruleus Ophthalmomaxillaris 59

Characteristics:

Orphanet epidemiological data:

59
nevus of ota
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA263425
ICD10 via Orphanet 34 D22.3
UMLS via Orphanet 74 C0027961

Summaries for Nevus of Ota

MalaCards based summary : Nevus of Ota, also known as nevus fusculoceruleus ophthalmomaxillaris, is related to melanoma, uveal and phacomatosis pigmentovascularis. An important gene associated with Nevus of Ota is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are DNA Double Strand Break Response and Proteoglycans in cancer. Affiliated tissues include skin, eye and brain, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and digestive/alimentary

Wikipedia : 76 Nevus of Ota (also known as "congenital melanosis bulbi", "nevus fuscoceruleus ophthalmomaxillaris",... more...

Related Diseases for Nevus of Ota

Diseases related to Nevus of Ota via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 melanoma, uveal 29.8 BAP1 BRAF
2 phacomatosis pigmentovascularis 11.6
3 melanoma 10.7
4 meningeal melanocytoma 10.4
5 tièche-jadassohn nevus 10.4
6 cataract 10.2
7 open-angle glaucoma 10.2
8 mongolian spot 10.2
9 lentigines 10.0
10 nevus anemicus 10.0
11 sturge-weber syndrome 10.0
12 cutis marmorata telangiectatica congenita 10.0
13 glaucoma 3, primary congenital, a 10.0
14 retinitis pigmentosa 10.0
15 leber congenital amaurosis 4 10.0
16 melanoma metastasis 10.0
17 arteriovenous malformation 10.0
18 leopard syndrome 10.0
19 retinitis 10.0
20 meningeal melanoma 10.0
21 malignant choroid melanoma 10.0
22 cerebellar degeneration 10.0
23 intraocular melanoma 10.0
24 weber syndrome 10.0
25 hyperplastic polyposis syndrome 10.0 BRAF TP53
26 spitz nevus 10.0 BRAF TP53
27 mature teratoma 10.0 BRAF TP53
28 pleomorphic xanthoastrocytoma 10.0 BRAF TP53
29 giant cell glioblastoma 10.0 BRAF TP53
30 ganglioglioma 10.0 BRAF TP53
31 brain stem glioma 10.0 BRAF TP53
32 skin melanoma 10.0 BRAF TP53
33 anaplastic thyroid cancer 10.0 BRAF TP53
34 ovarian serous cystadenocarcinoma 10.0 BRAF TP53
35 adenocarcinoma 10.0 BRAF TP53
36 leukemia, chronic lymphocytic 2 10.0 BRAF TP53
37 colorectal adenocarcinoma 10.0 BRAF TP53
38 testicular germ cell tumor 10.0 BRAF TP53
39 differentiated thyroid carcinoma 10.0 BRAF TP53
40 renal cell carcinoma, papillary, 1 10.0 BRAF TP53
41 suppression of tumorigenicity 12 10.0 BRAF TP53
42 transitional cell carcinoma 10.0 BRAF TP53
43 adrenocortical carcinoma, hereditary 10.0 BRAF TP53
44 lynch syndrome 10.0 BRAF TP53
45 gastrointestinal stromal tumor 10.0 BRAF TP53
46 bladder urothelial carcinoma 10.0 BRAF TP53
47 adenoma 9.9 BRAF TP53
48 adamantinoma of long bones 9.9 BRAF TP53
49 lung squamous cell carcinoma 9.9 BRAF TP53
50 cholangiocarcinoma 9.9 BRAF TP53

Graphical network of the top 20 diseases related to Nevus of Ota:



Diseases related to Nevus of Ota

Symptoms & Phenotypes for Nevus of Ota

GenomeRNAi Phenotypes related to Nevus of Ota according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.8 BAP1 BRAF TP53

MGI Mouse Phenotypes related to Nevus of Ota:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 BAP1 BRAF TP53
2 muscle MP:0005369 9.33 BAP1 BRAF TP53
3 neoplasm MP:0002006 9.13 BAP1 BRAF TP53
4 respiratory system MP:0005388 8.8 BAP1 BRAF TP53

Drugs & Therapeutics for Nevus of Ota

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optical Clearing of the Skin in Conjunction With Laser Treatments Completed NCT00580736 Phase 1
2 Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following Laser Treatment Completed NCT00287001 Not Applicable

Search NIH Clinical Center for Nevus of Ota

Genetic Tests for Nevus of Ota

Anatomical Context for Nevus of Ota

MalaCards organs/tissues related to Nevus of Ota:

41
Skin, Eye, Brain, Pineal, Lung, Bone, Thyroid

Publications for Nevus of Ota

Articles related to Nevus of Ota:

(show top 50) (show all 204)
# Title Authors Year
1
A study on the clinical characteristics of treating nevus of Ota by Q-switched Nd:YAG laser. ( 28986651 )
2018
2
Examination of the melanocytes of the Nevus of Ota with in vivo reflectance confocal microscopy: 15 cases. ( 29314292 )
2018
3
A retrospective analysis of the clinical efficacies and recurrence of Q-switched Nd:YAG laser treatment of nevus of Ota in 224 Chinese patients. ( 29521541 )
2018
4
Nevus of Ota associated with a primary uveal melanoma and intracranial melanoma metastasis. ( 30372724 )
2018
5
Successful and safe use of Q-switched lasers in the treatment of nevus of Ota in children with phototypes IV-VI. ( 29131366 )
2018
6
Picosecond Laser Treatment for Acquired Bilateral Nevus of Ota-like Macules. ( 30208473 )
2018
7
Clinical profile and triggering factors for acquired, bilateral nevus of Ota-like macules. ( 28122465 )
2017
8
Erratum: Treatment and Classification of Nevus of Ota: A Seven-Year Review of a Single Institution's Experience. ( 28932095 )
2017
9
A Split-Face, Single-Blinded, Randomized Controlled Comparison of Alexandrite 755 nm Picosecond Laser vs. Alexandrite 755 nm Nanosecond Laser in the Treatment of Acquired Bilateral Nevus of Ota-like Macules (ABNOM). ( 29288102 )
2017
10
Nevus of Ota (oculodermal melanocytosis) in a dog. ( 28745006 )
2017
11
Ocular Features in a Case of Nevus of Ota. ( 28302248 )
2017
12
A split-face comparison of Q-switched Nd:YAG 1064-nm laser for facial rejuvenation in Nevus of Ota patients. ( 28299489 )
2017
13
Treatment and Classification of Nevus of Ota: A Seven-Year Review of a Single Institution's Experience. ( 28761293 )
2017
14
Comparison of clinical efficacy and complications between Q-switched alexandrite laser and Q-switched Nd:YAG laser on nevus of Ota: a systematic review and meta-analysis. ( 26861980 )
2016
15
A Retrospective Study on the Characteristics of Treating Nevus of Ota by 1064-nm Q-switched Neodymium-doped Yttrium Aluminum Garnet Laser. ( 27293272 )
2016
16
Analysis of 28 Chinese Cases of Bilateral Nevus of Ota and Therapeutic Results With the Q-Switched Alexandrite Laser. ( 26808181 )
2016
17
Primary melanoma of the leptomeninges with bap1 expression-loss in the setting of a nevus of ota: A clinical, morphological and genetic study of 2 cases. ( 26834043 )
2016
18
Induction of melasma by 1064-nm Q-switched neodymium:yttrium-aluminum-garnet laser therapy for acquired bilateral nevus of Ota-like macules (Hori nevus): A study on related factors in the Chinese population. ( 26777390 )
2016
19
Three cases of symmetrical nevus of Ota and a brief literature review. ( 26889643 )
2016
20
Nevus of Ota. ( 27734644 )
2016
21
Phakomatosis pigmentovascularis type IIb: A case with Klippel-TrenA!unay syndrome and extensive dermal melanocytosis as nevus of Ota, nevus of Ito and ectopic Mongolian spots. ( 27374914 )
2016
22
An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota. ( 27699140 )
2016
23
Recurrence of Nevus of Ota after Successful Laser Treatment: Possible Role of Dermal Stem Cells. ( 27746651 )
2016
24
Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations. ( 26701415 )
2016
25
The case of a boy with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita: a unique instance of phacomatosis pigmentovascularis. ( 26312661 )
2015
26
Factors affecting response and laser sessions and complications in Nevus of Ota treated by Q- switched alexandrite laser: A retrospective study. ( 25747257 )
2015
27
Spontaneous partial regression of nevus of Ota with the development of vitiligo. ( 26474418 )
2015
28
Giant Blue Nevus: A New Association to Nevus of Ota. ( 26121271 )
2015
29
A randomized, split-face clinical trial of Q-switched alexandrite laser versus Q-switched Nd:YAG laser in the treatment of bilateral nevus of Ota. ( 25968166 )
2015
30
Beneficial effects of early treatment of nevus of Ota with low-fluence 1,064-nm Q-switched Nd:YAG laser. ( 25485806 )
2015
31
Cerebellar meningeal melanocytoma associated with nevus of Ota: An extremely rare case. ( 26259856 )
2015
32
Nevus of Ota/oculodermal melancytosis: a rare report of an oral mucosal lesion involving the hard palate. ( 26682294 )
2015
33
Intermediate-grade meningeal melanocytoma associated with nevus of Ota: a case report and review of the literature. ( 25933209 )
2015
34
Giant nevus of Ota. ( 26265645 )
2015
35
Treatment of Nevus of Ota With a Picosecond 755-nm Alexandrite Laser. ( 25760558 )
2015
36
Lasers and nevus of Ota: a comprehensive review. ( 26563954 )
2015
37
An unusual case of nevus of Ota combined with nevus spilus. ( 24962014 )
2014
38
A retrospective study on laser treatment of nevus of Ota in Chinese children--a seven-year follow-up. ( 24684590 )
2014
39
Bilateral familial nevus of Ota. ( 25448143 )
2014
40
Acquired Bilateral Nevus of ota-like Macules with Mucosal Involvement: A New Variant of Hori's Nevus. ( 24891664 )
2014
41
Comparison of acquired bilateral nevus of Ota-like macules in men and women. ( 25035355 )
2014
42
Centrally located acquired bilateral nevus of ota-like macules: a bizarre pattern. ( 25823087 )
2014
43
A retrospective analysis of the clinical efficacies of Q-switched Alexandrite and Q-switched Nd:YAG lasers in the treatment of nevus of Ota in Korean patients. ( 24888365 )
2014
44
Nevus of ota"- a rare pigmentation disorder with intraoral findings. ( 25302286 )
2014
45
Pigment reduction in nevus of Ota following leech therapy. ( 24948864 )
2014
46
BRAF V600E mutation in two distinct meningeal melanocytomas associated with a nevus of Ota. ( 24493731 )
2014
47
Orbital melanocytoma completely resected with conservative surgery in association with ipsilateral nevus of Ota: Report of a case and review of the literature. ( 24989678 )
2014
48
Animal-type malignant melanoma associated with nevus of Ota in the orbit of a Japanese woman: a case report. ( 24686419 )
2014
49
Nevus of ota. ( 24986303 )
2014
50
Pruritic acquired nevus of Ota. ( 24060704 )
2013

Variations for Nevus of Ota

Expression for Nevus of Ota

Search GEO for disease gene expression data for Nevus of Ota.

Pathways for Nevus of Ota

GO Terms for Nevus of Ota

Cellular components related to Nevus of Ota according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 8.8 BAP1 BRAF TP53

Biological processes related to Nevus of Ota according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein deubiquitination GO:0016579 8.96 BAP1 TP53
2 cellular response to drug GO:0035690 8.62 BRAF TP53

Sources for Nevus of Ota

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17 ExPASy
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33 ICD10
34 ICD10 via Orphanet
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45 MESH via Orphanet
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54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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