MCID: NVS007
MIFTS: 28

Nevus of Ota

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Nevus of Ota

MalaCards integrated aliases for Nevus of Ota:

Name: Nevus of Ota 58 17
Nevus Fusculoceruleus Ophthalmomaxillaris 58

Characteristics:

Orphanet epidemiological data:

58
nevus of ota
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 via Orphanet 33 D22.3
UMLS via Orphanet 72 C0027961
Orphanet 58 ORPHA263425

Summaries for Nevus of Ota

MalaCards based summary : Nevus of Ota, also known as nevus fusculoceruleus ophthalmomaxillaris, is related to melanoma, uveal and skin melanoma. An important gene associated with Nevus of Ota is BAP1 (BRCA1 Associated Protein 1), and among its related pathways/superpathways are MAPK Pathway and Glioblastoma Multiforme. Affiliated tissues include eye, skin and pineal.

Wikipedia : 74 Nevus of Ota is a blue[dubious - discuss] hyperpigmentation that occurs on the face, most often... more...

Related Diseases for Nevus of Ota

Diseases related to Nevus of Ota via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 melanoma, uveal 30.2 TP53 BRAF BAP1
2 skin melanoma 30.1 TP53 BRAF BAP1
3 phacomatosis pigmentovascularis 11.3
4 dowling-degos disease 1 10.8
5 melanoma 10.6
6 tièche-jadassohn nevus 10.6
7 meningeal melanocytoma 10.5
8 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.5
9 intraocular pressure quantitative trait locus 10.4
10 hemangioma 10.4
11 open-angle glaucoma 10.3
12 mongolian spot 10.3
13 exophthalmos 10.3
14 malignant choroid melanoma 10.3
15 neurofibromatosis 10.3
16 47,xyy 10.3
17 sturge-weber syndrome 10.2
18 branchiootic syndrome 1 10.2
19 meningioma, familial 10.2
20 spinal meningioma 10.2
21 neurilemmoma 10.2
22 secretory meningioma 10.2
23 lymphoplasmacyte-rich meningioma 10.2
24 meningeal melanoma 10.2
25 weber syndrome 10.2
26 rhabdoid meningioma 10.1 BRAF BAP1
27 peritoneum cancer 10.1 TP53 BAP1
28 mucosal melanoma 10.0 BRAF BAP1
29 spitz nevus 10.0 TP53 BRAF
30 pleural cancer 10.0 TP53 BAP1
31 lip cancer 10.0 TP53 BRAF
32 adenofibroma 10.0 TP53 BRAF
33 nodular malignant melanoma 10.0 TP53 BRAF
34 brooke-spiegler syndrome 10.0 TP53 BAP1
35 anisocoria 10.0
36 epidermoid cysts 10.0
37 klippel-trenaunay-weber syndrome 10.0
38 lentigines 10.0
39 lipomatosis, multiple 10.0
40 nevus, epidermal 10.0
41 nevus anemicus 10.0
42 scleroderma, familial progressive 10.0
43 spinocerebellar ataxia 2 10.0
44 vitiligo-associated multiple autoimmune disease susceptibility 6 10.0
45 arachnoid cysts, intracranial 10.0
46 cutis marmorata telangiectatica congenita 10.0
47 melanosis, neurocutaneous 10.0
48 retinitis pigmentosa 10.0
49 yemenite deaf-blind hypopigmentation syndrome 10.0
50 becker nevus syndrome 10.0

Symptoms & Phenotypes for Nevus of Ota

Drugs & Therapeutics for Nevus of Ota

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optical Clearing of the Skin in Conjunction With Laser Treatments Completed NCT00580736 Phase 1
2 Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following a Q-Switched Nd:YAG Laser Treatment of Acquired Bilateral Nevus of Ota-Like Macules Completed NCT00287001
3 A Retrospective Study on Laser Treatment of Nevus of Ota in Thai Patients Not yet recruiting NCT04481178

Search NIH Clinical Center for Nevus of Ota

Genetic Tests for Nevus of Ota

Anatomical Context for Nevus of Ota

MalaCards organs/tissues related to Nevus of Ota:

40
Eye, Skin, Pineal

Publications for Nevus of Ota

Articles related to Nevus of Ota:

(show top 50) (show all 369)
# Title Authors PMID Year
1
Nevus of Ota with midface tumors and a vanishing orbital mass. 61
33190058 2021
2
Long-Term Follow-Up for Q-Switched Nd:YAG Treatment of Nevus of Ota: Are High Number of Treatments Really Required? A Case Report. 61
32758019 2021
3
Novel Findings about Myopia in Patients with Oculodermal Melanocytosis (Nevus of Ota). 61
33541159 2021
4
Fatal GNAQ-mutated CNS melanoma in an adolescent with nevus of Ota. 61
33421174 2021
5
Use of a Picosecond Alexandrite Laser for Treating Acquired Bilateral Nevus of Ota-Like Macules in Chinese Patients. 61
32282092 2020
6
[Treatment of nevus of Ota and Ito and epidermal nevus syndrome]. 61
33145623 2020
7
[Laser treatment of pigmentation disorders]. 61
33159249 2020
8
A Prospective, Split-Face, Randomized Study Comparing Picosecond to Q-Switched Nd: YAG Laser for Treatment of Epidermal and Dermal Pigmented Lesions in Asians. 61
32604235 2020
9
Combination of 1064-nm Q-switched neodymium-doped yttrium-aluminum-garnet laser with Modified Jessner's peel for the treatment of Nevus of Ota: A case series of seven patients. 61
33089642 2020
10
Case report: nevus of Ota and nevus of Ito associated with meningeal melanocytosis. 61
31780112 2020
11
Melanoma in the setting of nevus of Ota: a review for dermatologists. 61
32808287 2020
12
Comparison of a picosecond alexandrite laser versus a Q-switched alexandrite laser for the treatment of nevus of Ota: A randomized, split-lesion, controlled trial. 61
30885760 2020
13
Efficacy and safety of the picosecond 755-nm alexandrite laser for treatment of dermal pigmentation in Asians-a retrospective study. 61
31965352 2020
14
Comparing the efficacy and safety of Q-switched and picosecond lasers in the treatment of nevus of Ota: a systematic review and meta-analysis. 61
32839837 2020
15
Ocular manifestations of facial port-wine stain, nevus of Ota, and phakomatosis pigmentovascularis in Asian patients. 61
32387657 2020
16
[Nevus of Ota: A case report]. 61
32035632 2020
17
A Study of Quality of Life in Patients with Facial Melanoses. 61
32477971 2020
18
In vivo reflectance confocal microscopy for evaluating common facial hyperpigmentation. 61
31544996 2020
19
Dermoscopic Findings of Nevus of Ota 61
31852034 2020
20
Successful and quick treatment of nevus of Ota with 755nm picosecond laser in Chinese. 61
32160794 2020
21
Gingival Lesion in a 23-Year-Old Woman with Nevus of Ota in the Gingiva. 61
32790614 2020
22
Congenital Triangular Alopecia Associated with Phakomatosis Pigmentovascularis Type II along with Klippel Trenaunay Syndrome. 61
32055518 2020
23
Neurofibromatosis Type 1 with Becker's Nevus and Nevus of Ota. 61
32029954 2020
24
Successful treatment of a patient with multicolored nevus of Ota using a combination of 1064 and 532 nm Q-switched Nd:YAG lasers. 61
31825275 2020
25
An extensive nevus of Ota with oro-buccal involvement: a case review and proposal of a new classification system. 61
31638352 2019
26
Clinical characteristics and treatment of 52 cases of phakomatosis pigmentovascularis. 61
31389056 2019
27
Clinical and genetic characteristics of nevus of Ota with choroidal melanoma in Chinese. 61
31407624 2019
28
Correction to: Nevus of Ota - an intraoral presentation: a case report. 61
31391114 2019
29
Nevus of Ota, a classic presentation. 61
30591278 2019
30
Meningeal Melanocytoma Associated with Nevus of Ota: Analysis of Twelve Reported Cases. 61
30904806 2019
31
Glaucoma in Phacomatosis Pigmentovascularis in a Young African Adolescent Boy: A Case Report. 61
30994485 2019
32
Nevus of Ota - an intraoral presentation: a case report. 61
31171040 2019
33
GNAQ and PMS1 Mutations Associated with Uveal Melanoma, Ocular Surface Melanosis, and Nevus of Ota. 61
31367589 2019
34
Oculodermal Melanocytosis: Nevus of Ota in a Dog. 61
30686121 2019
35
Phakomatosis Pigmentovascularis: A Clinical Profile of 11 Indian Patients. 61
31148861 2019
36
Variables that predict response of nevus of ota to lasers. 61
30723997 2019
37
Characteristics and management of Asian skin. 61
30039861 2019
38
Optimizing Q-switched lasers for melasma and acquired dermal melanoses. 61
30027914 2019
39
Usefulness of picosecond pulse alexandrite laser treatment for nevus of Ota. 61
31182899 2018
40
Treatment of flat and elevated pigmented disorders with a 755-nm alexandrite picosecond laser: clinical and histological evaluation. 61
29423841 2018
41
A retrospective analysis of the clinical efficacies and recurrence of Q-switched Nd:YAG laser treatment of nevus of Ota in 224 Chinese patients. 61
29521541 2018
42
Picosecond Laser Treatment for Acquired Bilateral Nevus of Ota-like Macules. 61
30208473 2018
43
A split-face, single-blinded, randomized controlled comparison of alexandrite 755-nm picosecond laser versus alexandrite 755-nm nanosecond laser in the treatment of acquired bilateral nevus of Ota-like macules. 61
29288102 2018
44
Nevus of Ota associated with a primary uveal melanoma and intracranial melanoma metastasis. 61
30372724 2018
45
Classification of non-tumorous skin pigmentation disorders using voting based probabilistic linear discriminant analysis. 61
29909227 2018
46
Port-wine stain as a clue for two rare coexisting entities. 61
30007908 2018
47
Examination of the melanocytes of the Nevus of Ota with in vivo reflectance confocal microscopy: 15 cases. 61
29314292 2018
48
Orbital melanocytoma: When a tumor becomes a relieving surprise. 61
29687085 2018
49
Nevus of Ota (oculodermal melanocytosis) in a dog. 61
28745006 2018
50
[Supratentorial Meningeal Melanoma with Nevus of Ota:A Case Report]. 61
29449519 2018

Variations for Nevus of Ota

Expression for Nevus of Ota

Search GEO for disease gene expression data for Nevus of Ota.

Pathways for Nevus of Ota

Pathways related to Nevus of Ota according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.42 TP53 BRAF
2 11.3 TP53 BRAF
3 11.18 TP53 BRAF
4 10.85 TP53 BRAF
5 10.49 TP53 BRAF

GO Terms for Nevus of Ota

Biological processes related to Nevus of Ota according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to drug GO:0035690 8.62 TP53 BRAF

Sources for Nevus of Ota

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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