MCID: NWB001
MIFTS: 52

Newborn Respiratory Distress Syndrome

Categories: Fetal diseases, Respiratory diseases

Aliases & Classifications for Newborn Respiratory Distress Syndrome

MalaCards integrated aliases for Newborn Respiratory Distress Syndrome:

Name: Newborn Respiratory Distress Syndrome 38 12 15
Hyaline Membrane Disease 12 55 44 73
Neonatal Respiratory Distress 29 6
Pulmonary Hypoperfusion Syndrome of Newborn 12
Respiratory Distress Syndrome of Newborn 12
Neonatal Respiratory Distress Syndrome 12
Respiratory Distress Syndrome, Newborn 73
Pulmonary Hyaline Membrane Disease 12
Hmd - Hyaline Membrane Disease 12
Respiratory Distress Syndrome 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12716
ICD10 33 P22.0
MeSH 44 D006819

Summaries for Newborn Respiratory Distress Syndrome

Disease Ontology : 12 A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.

MalaCards based summary : Newborn Respiratory Distress Syndrome, also known as hyaline membrane disease, is related to respiratory distress syndrome in premature infants and choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction, and has symptoms including apnea, cheyne-stokes respiration and coughing. An important gene associated with Newborn Respiratory Distress Syndrome is SFTPB (Surfactant Protein B), and among its related pathways/superpathways are Diseases of metabolism and Lung fibrosis. The drugs Infasurf and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include Lung and Lung, and related phenotypes are cardiovascular system and mortality/aging

Related Diseases for Newborn Respiratory Distress Syndrome

Diseases related to Newborn Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 respiratory distress syndrome in premature infants 30.6 ABCA3 SFTPB SFTPC
2 choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction 11.8
3 hemangioma of lung 10.6 NKX2-1 SFTPB
4 struma ovarii 10.6 BRAF NKX2-1
5 pulmonary sclerosing hemangioma 10.6 NKX2-1 SFTPB
6 sclerosing hemangioma 10.5 NKX2-1 SFTPB
7 papillary thyroid microcarcinoma 10.5 BRAF NKX2-1
8 cardiomyopathy, familial hypertrophic, 4 10.4 BRAF TTN
9 pulmonary immaturity 10.4 SFTPB SFTPC
10 diaphragm disease 10.4 SFTPB SFTPC
11 acute respiratory distress syndrome 10.3 SFTPB SFTPC
12 pulmonary alveolar proteinosis 10.3 SFTPB SFTPC
13 anaplastic thyroid cancer 10.3 BRAF NKX2-1
14 lung benign neoplasm 10.2 NKX2-1 SFTPC
15 diaphragmatic hernia, congenital 10.1 NKX2-1 SFTPB SFTPC
16 adult respiratory distress syndrome 10.1 SFTPB SFTPC
17 neonatal respiratory failure 10.1 ABCA3 SFTPB SFTPC
18 large cell carcinoma 10.1 NKX2-1 SFTPB
19 surfactant dysfunction 10.1 ABCA3 SFTPB SFTPC
20 nonspecific interstitial pneumonia 10.0 SERPINH1 SFTPC
21 lung cancer susceptibility 3 9.8 BRAF NKX2-1 SFTPB SFTPC
22 interstitial lung disease 9.7 ABCA3 NKX2-1 SFTPB SFTPC
23 diffuse pulmonary fibrosis 9.7 ABCA3 SERPINH1 SFTPC
24 respiratory failure 9.6 NKX2-1 SFTPB SFTPC TTN
25 idiopathic interstitial pneumonia 9.5 SFTPA2 SFTPC
26 lung disease 9.5 ABCA3 SFTPA2 SFTPB SFTPC
27 pulmonary fibrosis, idiopathic 8.8 ABCA3 SERPINH1 SFTPA2 SFTPB SFTPC

Graphical network of the top 20 diseases related to Newborn Respiratory Distress Syndrome:



Diseases related to Newborn Respiratory Distress Syndrome

Symptoms & Phenotypes for Newborn Respiratory Distress Syndrome

UMLS symptoms related to Newborn Respiratory Distress Syndrome:


apnea, cheyne-stokes respiration, coughing, dyspnea, hemoptysis, hoarseness, respiratory distress

MGI Mouse Phenotypes related to Newborn Respiratory Distress Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 ABCA3 BRAF NKX2-1 PLG SERPINH1 SFTPC
2 mortality/aging MP:0010768 9.61 ABCA3 BRAF COQ4 NKX2-1 PLG SERPINH1
3 respiratory system MP:0005388 9.17 ABCA3 BRAF NKX2-1 PLG SERPINH1 SFTPB

Drugs & Therapeutics for Newborn Respiratory Distress Syndrome

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Infasurf 18 CALFACTANT ONY July 1998

Drugs for Newborn Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 462)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 3,Not Applicable 59467-70-8 4192
2
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
3
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
4
Cisatracurium Approved Phase 4,Phase 3 96946-41-7
5
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
6
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-23-7 5754
7
Racepinephrine Approved Phase 4,Phase 2 329-65-7 838
8 Beractant Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 108778-82-1
9
Budesonide Approved Phase 4,Phase 2,Not Applicable 51333-22-3 63006 5281004
10 Poractant alfa Approved Phase 4,Phase 2,Phase 3,Not Applicable 129069-19-8
11
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
12
Clonidine Approved Phase 4 4205-90-7 2803
13 Nefopam Approved, Investigational Phase 4 13669-70-0
14
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
15
Sufentanil Approved, Investigational Phase 4,Phase 3 56030-54-7 41693
16
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
17
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 83-43-2 6741
18
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-24-8 5755
19
Atracurium Approved, Experimental, Investigational Phase 4,Not Applicable 64228-79-1 47319
20
Carbon monoxide Approved, Investigational Phase 4,Phase 1 630-08-0 281
21
Atropine Approved, Vet_approved Phase 4,Not Applicable 5908-99-6, 51-55-8 174174
22
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 378-44-9 9782
23
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
24
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 57-83-0 5994
25
Menthol Approved Phase 4,Phase 3,Phase 2,Not Applicable 2216-51-5 16666
26
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-66-6 23994
27
Povidone-iodine Approved Phase 4,Phase 3,Phase 2 25655-41-8
28
Metformin Approved Phase 4,Phase 2,Phase 3,Not Applicable 657-24-9 14219 4091
29
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 57-27-2 5288826
30
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
31
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
32
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-02-2 5743
33
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
34
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 113775-47-6 68602 5311068
35
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
36
Misoprostol Approved Phase 4,Not Applicable 59122-46-2 5282381
37
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
38
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
39
Metronidazole Approved Phase 4,Phase 2,Phase 3,Not Applicable 443-48-1 4173
40
Labetalol Approved Phase 4 36894-69-6 3869
41
Nifedipine Approved Phase 4,Phase 3 21829-25-4 4485
42 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
43
Serine Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 56-45-1 5951
44
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 56-40-6 750
45
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
46
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
47
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 77-92-9 311
48
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7
49
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3 67-97-0 6221 5280795
50
Butyric Acid Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 107-92-6 264

Interventional clinical trials:

(show top 50) (show all 1154)
# Name Status NCT ID Phase Drugs
1 Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS) Unknown status NCT00797160 Phase 4 propofol
2 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
3 Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway Unknown status NCT01173237 Phase 4
4 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
5 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
6 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
7 Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
8 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
9 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
10 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
11 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
12 The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
13 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
14 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
15 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
16 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
17 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
18 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
19 Corticosteroid Mediates Acute Respiratory Distress Syndrome Completed NCT02819453 Phase 4 Methylprednisolone
20 Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome Completed NCT00391105 Phase 4 Remifentanil
21 Effects of Bolus Surfactant Therapy on Peripheral Perfusion Index and Tissue Carbon Monoxide Completed NCT01923844 Phase 4 exogenous surfactant
22 Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) Completed NCT01600651 Phase 4
23 Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation Completed NCT01042600 Phase 4
24 Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study) Completed NCT02166853 Phase 4 sevoflurane;midazolam
25 Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
26 Caesarean and Corticotherapy Completed NCT00446953 Phase 4 betamethasone
27 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
28 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
29 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
30 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
31 Vaginal Progesterone for Prevention of Preterm Labor in Asymptomatic Twin Pregnancies With Sonographic Short Cervix Completed NCT02338830 Phase 4 Progesterone
32 Steroids in Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
33 On Versus Off Pump Myocardial Revascularization Study Completed NCT01290952 Phase 4
34 A Randomized Trial Comparing the Impact of One Versus Two Courses of Antenatal Steroids (ACS) on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
35 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
36 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
37 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
38 Long Protocol and Freeze All Embryos vs Antagonist Protocol With Fresh Embryo Transfer in PCOS Patients Undergoing ICSI Completed NCT03118830 Phase 4 Triptorelin;cetrorelix;Recombinant Follicle Stimulating Hormone
39 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
40 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
41 Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study) Completed NCT01282996 Phase 4
42 Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
43 Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome Recruiting NCT01731795 Phase 4 Dexamethasone
44 Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome Recruiting NCT02164734 Phase 4 remifentanil
45 Efficacy of Adding Budesonide to Poractant Alfa to Prevent Bronchopulmonary Dysplasia. Recruiting NCT03521063 Phase 4 Budesonide;Poractant Alfa;Saline
46 Effect of Antenatal Steroid on Pulmonary Artery Blood Flow Recruiting NCT02978976 Phase 4 Betamethasone;saline
47 The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone
48 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients Recruiting NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
49 Vaginal Progesterone Versus Cervical Cerclage for Pregnant Women With Short Cervix and History of PTL and/or MTM Recruiting NCT02673359 Phase 4 Progesterone
50 Dexmedetomidine Versus Standard Clinical Practice During Non Invasive Mechanical Ventilation Recruiting NCT02958150 Phase 4 Dexmedetomidine

Search NIH Clinical Center for Newborn Respiratory Distress Syndrome

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: hyaline membrane disease

Genetic Tests for Newborn Respiratory Distress Syndrome

Genetic tests related to Newborn Respiratory Distress Syndrome:

# Genetic test Affiliating Genes
1 Neonatal Respiratory Distress 29

Anatomical Context for Newborn Respiratory Distress Syndrome

MalaCards organs/tissues related to Newborn Respiratory Distress Syndrome:

41
Lung, Brain, Cervix, Testes, Liver, Fetal Lung, Heart
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Newborn Respiratory Distress Syndrome:
# Tissue Anatomical CompartmentCell Relevance
1 Lung Alveoli Alveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 Lung Alveoli Alveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 Lung Pulmonary Capillary Plexus Affected by disease

Publications for Newborn Respiratory Distress Syndrome

Articles related to Newborn Respiratory Distress Syndrome:

(show top 50) (show all 65)
# Title Authors Year
1
[Risk factors on the occurrence and prognosis of neonatal hyaline membrane disease]. ( 20848797 )
2010
2
[Expression of nuclear factor-kappaB and its inhibitor in alveolar macrophages of patients with neonatal hyaline membrane disease]. ( 17083791 )
2006
3
Nuclear factor kappaB activation in pulmonary leukocytes from infants with hyaline membrane disease: associations with chorioamnionitis and Ureaplasma urealyticum colonization. ( 15746262 )
2005
4
Deficient Na+ channel expression in newborn respiratory distress syndrome. ( 15029631 )
2004
5
[Value of prenatal corticotherapy in the prevention of hyaline membrane disease in premature infants. Randomized prospective study]. ( 12534029 )
2002
6
Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD). ( 12005259 )
2001
7
Interleukin-8 expression by fetal and neonatal pulmonary cells in hyaline membrane disease and amniotic infection. ( 10960493 )
2000
8
New-born infants with severe hyaline membrane disease: radiological evaluation during high frequency oscillatory versus conventional ventilation. ( 9881260 )
1998
9
The effects of IL-10 on proinflammatory cytokine expression (IL-1beta and IL-8) in hyaline membrane disease (HMD). ( 9683557 )
1998
10
Hyaline membrane disease is underreported in a linked birth-infant death certificate database. ( 9736884 )
1998
11
Differential regulation of IL-8 by IL-1beta and TNFalpha in hyaline membrane disease. ( 9475356 )
1998
12
Changes in anti-oxidant enzymes and lipid peroxidation in hyaline membrane disease. ( 10773913 )
1998
13
Undetectable interleukin (IL)-10 and persistent IL-8 expression early in hyaline membrane disease: a possible developmental basis for the predisposition to chronic lung inflammation in preterm newborns. ( 8725256 )
1996
14
Effects of increased red cell mass on subclinical tissue acidosis in hyaline membrane disease. ( 8949689 )
1996
15
Validation of a nitrogen washout system to measure functional residual capacity in premature infants with hyaline membrane disease. ( 8649921 )
1995
16
Effects of morphine and pancuronium on lung volume and oxygenation in premature infants with hyaline membrane disease. ( 8021797 )
1994
17
Immunohistochemical study of copper-zinc and manganese superoxide dismutases in the lungs of human fetuses and newborn infants: developmental profile and alterations in hyaline membrane disease and bronchopulmonary dysplasia. ( 8236811 )
1993
18
Air embolism and pulmonary interstitial emphysema in a preterm infant with hyaline membrane disease. ( 1771121 )
1991
19
Systemic air embolism: a complication of ventilator therapy in hyaline membrane disease. ( 1999066 )
1991
20
Lipid peroxidation and expression of copper-zinc and manganese superoxide dismutase in lungs of premature infants with hyaline membrane disease and bronchopulmonary dysplasia. ( 2230537 )
1990
21
Treatment of severe hyaline membrane disease with surfactant (Curosurf). A collaborative clinical study. ( 2083097 )
1990
22
Lung function 8-18 years after intermittent positive pressure ventilation for hyaline membrane disease. ( 2281428 )
1990
23
Effects of exogenous surfactant therapy on dynamic compliance during mechanical breathing in preterm infants with hyaline membrane disease. ( 2404097 )
1990
24
Effect of spontaneous and mechanical breathing on dynamic lung mechanics in hyaline membrane disease. ( 2371070 )
1990
25
Effect of exogenous surfactant on the development of bronchopulmonary dysplasia in a baboon hyaline membrane disease model. ( 2318051 )
1990
26
High viscosity of newborn extracellular matrix is the etiology of erythema toxicum neonatorum: neonatal jaundice?: hyaline membrane disease? ( 2255269 )
1990
27
Pulmonary vascular damage and the development of cor pulmonale following hyaline membrane disease. ( 2148977 )
1990
28
[Hyaline membrane disease in the premature infant: diagnostic aspects and therapeutic prospects (excluding mechanical ventilation)]. ( 2814266 )
1989
29
Oliguria in the premature baboon with hyaline membrane disease: a manifestation of multisystem immaturity? ( 2651593 )
1989
30
Double-blind controlled trial of single-dose treatment with bovine surfactant in severe hyaline membrane disease. ( 2882083 )
1987
31
Optimal constant positive airway pressure assessed by arterial alveolar difference for CO2 in hyaline membrane disease. ( 3092178 )
1986
32
[Prevention of hyaline membrane disease]. ( 3785233 )
1986
33
Reduced incidence of hyaline membrane disease in extremely premature infants following delay of delivery in mother with preterm labor: use of ritodrine and betamethasone. ( 3532016 )
1986
34
Double-blind clinical trial of calf lung surfactant extract for the prevention of hyaline membrane disease in extremely premature infants. ( 3900906 )
1985
35
Abnormal serum protein levels in infants with hyaline membrane disease--evidence of an underlying immunological disorder. ( 2580359 )
1985
36
Bovine surfactant (surfactant TA) therapy in immature baboons with hyaline membrane disease. ( 3846883 )
1985
37
Pulmonary interstitial emphysema in the premature baboon with hyaline membrane disease. ( 6373147 )
1984
38
Exogenous surfactant therapy in hyaline membrane disease. ( 6387924 )
1984
39
Effect of high-frequency oscillation on gas exchange and pulmonary phospholipids in experimental hyaline membrane disease. ( 6342479 )
1983
40
Antenatal glucocorticoid administration: effects on oxygen-hemoglobin affinity and hemoglobin levels in experimental hyaline membrane disease. ( 6687717 )
1983
41
Prediction of the newborn respiratory distress syndrome by means of the hydrogen peroxide hemolysis test. ( 6895985 )
1982
42
An old problem revisited--hyaline membrane disease and Cesarean section. ( 7151831 )
1982
43
A quantitative model for hyaline membrane disease. ( 7070873 )
1982
44
Review of experimental hyaline membrane disease. ( 7018865 )
1981
45
Differential effect of sex in experimental hyaline membrane disease in newborn monkeys. ( 6794396 )
1981
46
Respiratory distress syndrome (hyaline membrane disease). ( 7021069 )
1981
47
Patent ductus arteriosus in hyaline membrane disease: chest radiography. ( 6773332 )
1980
48
High frequency mechanical ventilation in severe hyaline membrane disease an alternative treatment? ( 6989552 )
1980
49
Sequential changes of surfactant phosphatidylcholine in hyaline-membrane disease of the newborn. ( 581511 )
1979
50
Airway resistance in infants after various treatments for hyaline membrane disease: special emphasis on prolonged high levels of inspired oxygen. ( 345207 )
1978

Variations for Newborn Respiratory Distress Syndrome

ClinVar genetic disease variations for Newborn Respiratory Distress Syndrome:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 BRAF NM_004333.4(BRAF): c.1502A> G (p.Glu501Gly) single nucleotide variant Pathogenic/Likely pathogenic rs180177039 GRCh37 Chromosome 7, 140477806: 140477806
2 BRAF NM_004333.4(BRAF): c.1502A> G (p.Glu501Gly) single nucleotide variant Pathogenic/Likely pathogenic rs180177039 GRCh38 Chromosome 7, 140778006: 140778006
3 ABCC8 NM_000352.4(ABCC8): c.3517G> A (p.Val1173Met) single nucleotide variant Likely pathogenic rs141322087 GRCh37 Chromosome 11, 17426099: 17426099
4 ABCC8 NM_000352.4(ABCC8): c.3517G> A (p.Val1173Met) single nucleotide variant Likely pathogenic rs141322087 GRCh38 Chromosome 11, 17404552: 17404552
5 ABCC8 NM_000352.4(ABCC8): c.1793G> A (p.Arg598Gln) single nucleotide variant Likely pathogenic GRCh38 Chromosome 11, 17430838: 17430838
6 ABCC8 NM_000352.4(ABCC8): c.1793G> A (p.Arg598Gln) single nucleotide variant Likely pathogenic GRCh37 Chromosome 11, 17452385: 17452385

Expression for Newborn Respiratory Distress Syndrome

Search GEO for disease gene expression data for Newborn Respiratory Distress Syndrome.

Pathways for Newborn Respiratory Distress Syndrome

Pathways related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.3 SFTPA2 SFTPB SFTPC
2 11.06 SFTPA2 SFTPC
3
Show member pathways
10.56 ABCA3 SFTPA2 SFTPB SFTPC
4
Show member pathways
10.53 SFTPA2 SFTPB SFTPC

GO Terms for Newborn Respiratory Distress Syndrome

Cellular components related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 ABCA3 PLG SERPINH1 SFTPA2 SFTPB SFTPC
2 multivesicular body GO:0005771 9.37 SFTPA2 SFTPB
3 multivesicular body lumen GO:0097486 9.26 SFTPB SFTPC
4 alveolar lamellar body GO:0097208 9.16 ABCA3 SFTPB
5 clathrin-coated endocytic vesicle GO:0045334 9.13 SFTPA2 SFTPB SFTPC
6 lamellar body GO:0042599 8.8 SFTPA2 SFTPB SFTPC

Biological processes related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.33 BRAF NKX2-1 SFTPB
2 thyroid gland development GO:0030878 9.26 BRAF NKX2-1
3 respiratory gaseous exchange GO:0007585 9.13 SFTPA2 SFTPB SFTPC
4 cellular protein metabolic process GO:0044267 9.02 ABCA3 PLG SFTPA2 SFTPB SFTPC

Sources for Newborn Respiratory Distress Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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