MCID: NWB001
MIFTS: 56

Newborn Respiratory Distress Syndrome

Categories: Fetal diseases, Respiratory diseases

Aliases & Classifications for Newborn Respiratory Distress Syndrome

MalaCards integrated aliases for Newborn Respiratory Distress Syndrome:

Name: Newborn Respiratory Distress Syndrome 12 15 17
Hyaline Membrane Disease 12 54 44 70
Respiratory Distress Syndrome of Newborn 12 32
Neonatal Respiratory Distress 29 6
Pulmonary Hypoperfusion Syndrome of Newborn 12
Neonatal Respiratory Distress Syndrome 12
Respiratory Distress Syndrome, Newborn 70
Pulmonary Hyaline Membrane Disease 12
Hmd - Hyaline Membrane Disease 12
Respiratory Distress Syndrome 70

Classifications:



External Ids:

Disease Ontology 12 DOID:12716
MeSH 44 D006819
SNOMED-CT 67 26168007
ICD10 32 P22 P22.0 P22.9
UMLS 70 C0020192 C0035220 C0852283

Summaries for Newborn Respiratory Distress Syndrome

Disease Ontology : 12 A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.

MalaCards based summary : Newborn Respiratory Distress Syndrome, also known as hyaline membrane disease, is related to respiratory distress syndrome in premature infants and respiratory distress syndrome, infant, and has symptoms including dyspnea, hemoptysis and apnea. An important gene associated with Newborn Respiratory Distress Syndrome is ABCA3 (ATP Binding Cassette Subfamily A Member 3), and among its related pathways/superpathways are Diseases of metabolism and Lung fibrosis. The drugs Hydrocortisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include Lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Newborn Respiratory Distress Syndrome

Diseases related to Newborn Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 respiratory distress syndrome in premature infants 32.9 SFTPC SFTPB SFTPA1 ABCA3
2 respiratory distress syndrome, infant 32.2 SFTPC GJB2 BRAF ABCC8 ABCA3
3 pulmonary interstitial emphysema 30.6 SFTPD SFTPC SFTPB SFTPA1 ABCA3
4 tracheal agenesis 30.5 SFTPD SFTPB
5 surfactant dysfunction 30.1 SFTPC SFTPB SFTPA1 ABCA3
6 asphyxia neonatorum 30.0 CRP ABCC8
7 meconium aspiration syndrome 30.0 SFTPB SCGB1A1 ABCA3
8 otitis media 29.9 SFTPA2 SFTPA1 CRP
9 pulmonary alveolar proteinosis 29.8 SFTPD SFTPC SFTPB SFTPA1
10 pulmonary immaturity 29.5 SFTPD SFTPC SFTPB SFTPA2 SFTPA1 ABCA3
11 bacterial pneumonia 29.4 SFTPD SFTPB SCGB1A1 CRP
12 adult respiratory distress syndrome 29.4 SFTPD SFTPC SFTPB SCGB1A1 GRP GJB2
13 pneumonia 29.3 SFTPD SFTPC SFTPB SCGB1A1 CRP
14 pulmonary fibrosis, idiopathic 28.6 SFTPD SFTPC SFTPB SFTPA2 SFTPA1 SCGB1A1
15 respiratory failure 28.5 TTN SFTPD SFTPC SFTPB SCGB1A1 NKX2-1
16 lung disease 28.0 SFTPD SFTPC SFTPB SFTPA2 SFTPA1 SCGB1A1
17 choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction 11.7
18 ciliary dyskinesia, primary, 26 11.3
19 ciliary dyskinesia, primary, 27 11.3
20 kartagener syndrome 11.1
21 ciliary dyskinesia, primary, 9 11.1
22 ciliary dyskinesia, primary, 38 11.1
23 neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation 11.1
24 bronchopulmonary dysplasia 10.7
25 patent ductus arteriosus 1 10.6
26 pneumothorax 10.5
27 chronic congestive splenomegaly 10.3 SFTPC ABCA3
28 pulmonary hemosiderosis 10.3 SFTPB ABCA3
29 pulmonary fibrosis predisposition 10.3 SFTPC SFTPA2
30 diffuse pulmonary fibrosis 10.3 GRP ABCA3
31 tall cell variant papillary carcinoma 10.3 NKX2-1 BRAF
32 situs inversus 10.3
33 papillary thyroid microcarcinoma 10.3 NKX2-1 BRAF
34 lung carcinoma in situ 10.3 SFTPC NKX2-1
35 pre-eclampsia 10.3
36 surfactant metabolism dysfunction, pulmonary, 1 10.3 SFTPC SFTPB ABCA3
37 pulmonary adenocarcinoma in situ 10.3 SFTPC NKX2-1
38 struma ovarii 10.3 NKX2-1 BRAF
39 myringitis bullosa hemorrhagica 10.3 SFTPA2 SFTPA1
40 ventilation pneumonitis 10.3 SFTPD ABCA3
41 gestational diabetes 10.2
42 primary interstitial lung disease specific to childhood due to pulmonary surfactant protein anomalies 10.2
43 teratoma 10.2
44 disseminated intravascular coagulation 10.2
45 pulmonary edema 10.2
46 benign struma ovarii 10.2 NKX2-1 BRAF
47 sclerosing hemangioma 10.2 SFTPB NKX2-1
48 paraquat lung 10.2 SFTPB SCGB1A1
49 toxic pneumonitis 10.2 SFTPB SCGB1A1
50 dacryocystocele 10.2

Graphical network of the top 20 diseases related to Newborn Respiratory Distress Syndrome:



Diseases related to Newborn Respiratory Distress Syndrome

Symptoms & Phenotypes for Newborn Respiratory Distress Syndrome

UMLS symptoms related to Newborn Respiratory Distress Syndrome:


dyspnea; hemoptysis; apnea; respiratory distress; cheyne-stokes respiration; coughing; hoarseness

GenomeRNAi Phenotypes related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10.05 BRAF
2 Decreased viability GR00055-A-2 10.05 BRAF
3 Decreased viability GR00221-A-2 10.05 TTN
4 Decreased viability GR00221-A-4 10.05 BRAF TTN
5 Decreased viability GR00240-S-1 10.05 PCYT1B
6 Decreased viability GR00249-S 10.05 BRAF SFTPA1
7 Decreased viability GR00301-A 10.05 BRAF
8 Decreased viability GR00342-S-1 10.05 TTN
9 Decreased viability GR00342-S-3 10.05 TTN
10 Decreased viability GR00381-A-1 10.05 BRAF EPPIN GRP LPCAT1
11 Decreased viability GR00381-A-3 10.05 GRP
12 Decreased viability GR00386-A-1 10.05 ABCA3 CHPT1 GRP PCYT1B
13 Decreased viability GR00402-S-2 10.05 ABCA3 GJB2 GRP IPO13 LPCAT1
14 Synthetic lethal with c-Myc after tamoxifen stimulation GR00215-A 8.92 ABCC8 BRAF CHPT1 CRP

MGI Mouse Phenotypes related to Newborn Respiratory Distress Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 ABCA3 ABCC8 BRAF CRP GJB2 GRP
2 mortality/aging MP:0010768 9.77 ABCA3 BRAF CHPT1 GJB2 IPO13 LPCAT1
3 respiratory system MP:0005388 9.32 ABCA3 BRAF GRP LPCAT1 NKX2-1 SCGB1A1

Drugs & Therapeutics for Newborn Respiratory Distress Syndrome

Drugs for Newborn Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 372)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
2
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
3
Iron Approved Phase 4 7439-89-6 23925 29936
4
Zinc Approved, Investigational Phase 4 7440-66-6 32051
5
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
6
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
7
Coal tar Approved Phase 4 8007-45-2
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
9
Caffeine Approved Phase 4 58-08-2 2519
10
Ibuprofen Approved Phase 4 15687-27-1 3672
11
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
12
Heparin Approved, Investigational Phase 4 9005-49-6 772 9812414
13
Remifentanil Approved Phase 4 132875-61-7 60815
14
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
15
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
16
Budesonide Approved Phase 4 51333-22-3 63006 5281004
17
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
18
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
19
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
20
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7 5280489
21
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
22
Sivelestat Investigational Phase 4 127373-66-4
23 Hydrocortisone hemisuccinate Phase 4
24 Hydrocortisone 17-butyrate 21-propionate Phase 4
25 Cholinergic Antagonists Phase 4
26 Cholinergic Agents Phase 4
27 Chelating Agents Phase 4
28 Carotenoids Phase 4
29 Iron Chelating Agents Phase 4
30
Picolinic acid Phase 4 98-98-6 1018
31 Provitamins Phase 4
32 Psychotropic Drugs Phase 4
33 Anti-Anxiety Agents Phase 4
34 GABA Modulators Phase 4
35 Neuromuscular Nondepolarizing Agents Phase 4
36 Serine Proteinase Inhibitors Phase 4
37 Anesthetics, Dissociative Phase 4
38 Excitatory Amino Acid Antagonists Phase 4
39 Analgesics, Non-Narcotic Phase 4
40 Antihypertensive Agents Phase 4
41 Angiotensin II Type 1 Receptor Blockers Phase 4
42 Angiotensin Receptor Antagonists Phase 4
43 Cyclooxygenase Inhibitors Phase 4
44 Anti-Inflammatory Agents, Non-Steroidal Phase 4
45 Tin Fluorides Phase 4
46
Glycopyrrolate Phase 4 596-51-0 3494
47 Fibrinolytic Agents Phase 4
48 calcium heparin Phase 4
49 Anticoagulants Phase 4
50 Narcotics Phase 4

Interventional clinical trials:

(show top 50) (show all 1205)
# Name Status NCT ID Phase Drugs
1 Efficacy Evaluation of Surfactant Administration for Respiratory Distress Syndrome Treatment Via Laryngeal Mask Airway. A Randomized Controlled Trial Unknown status NCT01173237 Phase 4
2 Routine Administration of Surfactant/Budesonide to Prevent BPD in VLBW With RDS-A Double Blind Study Unknown status NCT03275415 Phase 4 budesonide;Saline
3 The Effect of Maternal Antenatal Steroid Administration on the Blood Flow Through the Pulmonary Artery in the Term Fetus; a Randomized Control Double Blinded Study Unknown status NCT02978976 Phase 4 Betamethasone;saline
4 Efficacy of Rescue Surfactant Delivery Via Endotracheal Intubation (INSURE Technique) Versus Laryngeal Mask Airway (LMA) for Respiratory Distress Syndrome (RDS) in Preterm Neonates Unknown status NCT02164734 Phase 4 remifentanil
5 Effects of NMBA on the Alteration of Transpulmonary Pressures at the Early Phase of ARDS Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
6 Prevention of Chronic Lung Disease (CLD) in Preterm Infants -A New Therapeutic Regimen Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
7 Effect of Treatment With Stress-Doses Glucocorticoid on Mortality in Patients With ARDS and Relative Adrenal Insufficiency Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
8 Propofol and Remifentanil Versus Midazolam and Remifentanil as Premedication Allowing Very Early Extubation After Surfactant Treatment in Preterm Neonates With Respiratory Distress Syndrome Unknown status NCT00797160 Phase 4 propofol
9 Sleep Intervention During Acute Lung Injury Unknown status NCT01050699 Phase 4 Dexmedetomidine;Midazolam and Fentanyl
10 THE EFFECT OF SUSTAINED LUNG INFLATION MANEUVER APPLIED THROUGH NASAL PRONG ON EARLY AND LATE RESPIRATORY MORBIDITIES IN PRETERM INFANTS Unknown status NCT02887924 Phase 4
11 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
12 Early Bubble CPAP (EBCPAP) in Very Low Birth Weight Infants (VLBWI) Unknown status NCT00368680 Phase 4
13 Comparative Trial of Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
14 The Effect of Co-administered β-Carotene, Vitamin D3, Zinc and Antenatal Steroid Therapy on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Unknown status NCT03366584 Phase 4 Dexamethasone
15 Early Administration of Surfactant in Spontaneous Breathing (TAKE CARE) Versus InSurE (Intubation, Surfactant, Extubation) : A Pilot Study Unknown status NCT01329432 Phase 4
16 Functional Residual Capacity Guided Alveolar Recruitment Strategy in Patients With Acute Respiratory Failure After Cardiac Surgery Unknown status NCT01280019 Phase 4
17 A Multicentre, Randomized, Clinical Trial of Noninvasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure - NINAVAPed Protocol Unknown status NCT01873521 Phase 4
18 Effects of Bolus Surfactant Therapy on Serial Peripheral Perfusion Index and Tissue Carbon Monoxide Measurements in Preterm Infants With Severe Respiratory Distress Syndrome Completed NCT01923844 Phase 4 exogenous surfactant
19 Comparative Study of the Use of Remifentanil Versus Morphine for Sedation and Analgesia of Premature Neonates During Mechanical Ventilation in the Treatment of Respiratory Distress Syndrome (RDS) Completed NCT00391105 Phase 4 Remifentanil
20 Rescue Surfactant for Respiratory Distress Syndrome (RDS) in Newborns: Comparing Efficacy of Delivery Via Laryngeal Mask Airway to Delivery by Endotracheal Intubation Completed NCT01042600 Phase 4
21 An International, Open, Randomized, Controlled Study to Evaluate the Efficacy of Combining Prophylactic Curosurf® With Early Nasal CPAP Versus Early Nasal CPAP Alone in Very Preterm Infants at Risk of Respiratory Distress Syndrome Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
22 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
23 Assessment of the Cerebral Tissue Oxygenation and the Bioelectrical Brain Activity of Preterm Newborns During Administration of Two Different Surfactant Completed NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
24 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
25 Corticosteroid Mediates Acute Respiratory Distress Syndrome Via NLRP3 Inflammasome Signaling Pathway Completed NCT02819453 Phase 4 Methylprednisolone
26 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
27 A Comparative, Randomised Controlled Trial for Evaluating the Efficacy of Dexamethasone in the Treatment of Patients With Acute Respiratory Distress Syndrome Completed NCT01731795 Phase 4 Dexamethasone
28 Effects Of A Recruitment Maneuver On Plasma Levels of sRAGE, The Soluble Form of The Receptor For Advanced Glycation End Products, In Patients With Diffuse Acute Respiratory Distress Syndrome (ARDS) Completed NCT01600651 Phase 4
29 The Study of Pharmacokinetics and Pharmacodynamics of a Loading Dose Cisatracurium in Critically Ill Patients Completed NCT03337373 Phase 4 cisatracurium
30 Effect of Early 48-hour Sevoflurane Inhalation on Gas Exchange and Inflammation in Patients Presenting With Acute Respiratory Distress Syndrome (ARDS) : a Monocentric, Prospective, Randomized Study. Completed NCT02166853 Phase 4 sevoflurane;midazolam
31 Interest in Programming Caesarean Section at 38 Weeks of Pregnancy With Antenatal Betamethasone to Prevent Neonatal Respiratory Distress and to Avoid Emergency Caesarean Section Before Planned Date. Completed NCT00446953 Phase 4 betamethasone
32 Efficacy and Safety of Sivelestat Sodium Hydrate in Acute Lung Injury Associated With Systemic Inflammatory Response Syndrome, Compared With the Conventional Treatment in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
33 Efficacy of Adding Budesonide to Poractant Alfa to Prevent Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome. Recruiting NCT03521063 Phase 4 Budesonide;Poractant Alfa;Saline
34 Sedation With Sevoflurane Versus Propofol in Patients With Acute Respiratory Distress Syndrome Caused by COVID19 Infection Recruiting NCT04359862 Phase 4 Sevoflurane;Propofol
35 PRAETORIAN-COVID: A Double-blind, Placebo-controlled Randomized Clinical Trial With Valsartan for PRevention of Acute rEspiraTORy dIstress Syndrome in hospitAlized patieNts With SARS-COV-2 (COVID-19) Infection Disease Recruiting NCT04335786 Phase 4 Valsartan (Diovan);Placebo oral tablet
36 Lipid Ibuprofen Versus Standard of Care for Acute Hypoxemic Respiratory Failure Due to COVID-19: a Multicentre, Randomised, Controlled Trial Recruiting NCT04334629 Phase 4 Ibuprofen
37 Effect of Inhalation Sedation With Sevoflurane Compared With Propofol on the Sepsis-related Acute Respiratory Distress Syndrome (ARDS) Course. Recruiting NCT04014218 Phase 4 Inhalation Sedation;Intravenous Sedation
38 Premedication for Less Invasive Surfactant Administration Recruiting NCT03735563 Phase 4 Ketamine;Fentanyl
39 Exogenous Surfactant in Very Preterm Neonates Presenting With Severe Respiratory Distress in Prevention of Bronchopulmonary Dysplasia Active, not recruiting NCT01039285 Phase 4 Curosurf
40 Oxygenation Targets in Cardiac Surgery Patients - a Before-and-after Study Active, not recruiting NCT04133740 Phase 4 Oxygen
41 Nebulized Heparin vs. Placebo for the Treatment of COVID-19 Induced Lung Injury Enrolling by invitation NCT04397510 Phase 4 Heparin;0.9% Sodium-chloride
42 Role of Prophylactic Dexamethasone Administration Before Elective Cesarean Section at Term in Reducing the Incidence of Neonatal Respiratory Distress Syndrome (A Randomized Controlled Trial) Not yet recruiting NCT04816097 Phase 4 Dexamethasone phosphate
43 Comparison of Two Fraction Oxygen Inspired (FiO2) Thresholds for the Surfactant Administration in Preterm Infants With Respiratory Disease Syndrome: a Single-center Randomized Phase IV Clinical Trial Not yet recruiting NCT04199364 Phase 4 Poractant Alfa 80 mg/mL Intratracheal Suspension
44 Stress Assessment in Preterm Infants With Respiratory Distress Syndrome Treated or Not With an Analgesic Drug During the Traditional or the Less Invasive Method of Surfactant Therapy. Not yet recruiting NCT04073173 Phase 4 Analgesic, Opioid
45 The Effect of Spironolactone on Oxygenation in Covid-19 ARDS Patients Not yet recruiting NCT04345887 Phase 4 Spironolactone 100mg;Placebo oral tablet
46 Effects of Adding L-Carnitine With Dexamethasone on Respiratory Distress Syndrome Development in Preterm Infants Suspended NCT03630367 Phase 4 Dexamethasone;L-Carnitine 1G/5mL Injection
47 Phase 4 Study of Curosurf (Poractant) and Survanta (Beractant) Surfactant Treatment in Very Premature Infants With Respiratory Distress Syndrome. Terminated NCT00767039 Phase 4 Survanta (beractant);Curosurf (poractant)
48 Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19 Terminated NCT04325061 Phase 4 Dexamethasone
49 Randomized Study Comparing the ASV to Conventional Ventilation for Intubated Patients During Inter-hospital Transfers. Controlled Randomized Monocentric Prospective Study Comparing ASV Versus Conventional Ventilation Modes Terminated NCT02348047 Phase 4
50 Randomized Trial on Efficacy and Safety of the Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth (ACG Trial) Terminated NCT00295464 Phase 4 Betamethasone sodium phos (drug)

Search NIH Clinical Center for Newborn Respiratory Distress Syndrome

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Albumin Human, USP
ALBUMIN,AGGREGATED
ALBUMIN,EGG
ALBUMIN,HUMAN INJ
ALBUMIN,MICROSPHERE HUMAN SERUM
beractant
Colfosceril
colfosceril palmitate
Nitric Oxide
Poractant alfa

Cochrane evidence based reviews: hyaline membrane disease

Genetic Tests for Newborn Respiratory Distress Syndrome

Genetic tests related to Newborn Respiratory Distress Syndrome:

# Genetic test Affiliating Genes
1 Neonatal Respiratory Distress 29

Anatomical Context for Newborn Respiratory Distress Syndrome

MalaCards organs/tissues related to Newborn Respiratory Distress Syndrome:

40
Lung, Fetal Lung, Bone Marrow, Neutrophil, Liver, Bone, Placenta
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Newborn Respiratory Distress Syndrome:
# Tissue Anatomical CompartmentCell Relevance
1 Lung Pulmonary Capillary Plexus Affected by disease
2 Lung Alveoli Alveolar Epithelial Type 1 Cells Affected by disease, potential therapeutic candidate
3 Lung Alveoli Alveolar Epithelial Type 2 Cells Affected by disease, potential therapeutic candidate

Publications for Newborn Respiratory Distress Syndrome

Articles related to Newborn Respiratory Distress Syndrome:

(show top 50) (show all 1681)
# Title Authors PMID Year
1
Recurrent familial neonatal deaths: hereditary surfactant protein B deficiency. 61 54
11041444 2000
2
Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung. 54 61
8675988 1996
3
Immunohistochemical study of copper-zinc and manganese superoxide dismutases in the lungs of human fetuses and newborn infants: developmental profile and alterations in hyaline membrane disease and bronchopulmonary dysplasia. 54 61
8236811 1993
4
Pulmonary endocrine cells in infancy and childhood. 61 54
2014192 1991
5
Lipid peroxidation and expression of copper-zinc and manganese superoxide dismutase in lungs of premature infants with hyaline membrane disease and bronchopulmonary dysplasia. 61 54
2230537 1990
6
Maternal and Perinatal Factors Associated With Twin Pregnancies in Ecuador. 61
33752776 2021
7
Tension pneumocephalus, an uncommon complication of oxygen therapy in preterm newborns. Presentation of a case and literature review. 61
31784352 2021
8
Outcomes of newborns to mothers with COVID-19. 61
33748807 2021
9
Analysis of Pathology in Premature Infants in Obstetrics and Gynecology Clinic at St George University Hospital, Plovdiv between 2013 and 2015. 61
33650401 2021
10
Optimal delivery timing for twin pregnancies: A population-based retrospective cohort study. 61
33420725 2021
11
The burden of hyaline membrane disease, mortality and its determinant factors among preterm neonates admitted at Debre Tabor General Hospital, North Central Ethiopia: A retrospective follow up study. 61
33784349 2021
12
Surfactant dysfunction disorder masquerading as meconium aspiration syndrome and persistent pulmonary hypertension of the newborn. 61
33504532 2021
13
The impact of Ureaplasma infections on pregnancy complications. 61
32854606 2020
14
A survey on criteria for intubation in moderate to late preterm infants with respiratory distress. 61
32886426 2020
15
Comparison of Long Term Follow-up Chest CT Imaging in Adult and Pediatric Patients with Humidifier Disinfectant-related Lung Injury. 61
33230985 2020
16
Novel homozygous missense mutation in ABCA3 protein leading to severe respiratory distress in term infant. 61
33040033 2020
17
Bovine or Porcine: Does the Type of Surfactant Matter? 61
32112649 2020
18
Extrauterine growth restriction in very preterm infant: etiology, diagnosis, and 2-year follow-up. 61
32193657 2020
19
Neuroendoscopic lavage for the management of posthemorrhagic hydrocephalus in preterm infants: safety, effectivity, and lessons learned. 61
32413865 2020
20
Transcervical Foley Balloon Plus Vaginal Misoprostol versus Vaginal Misoprostol Alone for Cervical Ripening in Nulliparous Obese Women: A Multicenter, Randomized, Comparative-Effectiveness Trial. 61
32299108 2020
21
Inositol and pulmonary function. Could myo-inositol treatment downregulate inflammation and cytokine release syndrome in SARS-CoV-2? 61
32271462 2020
22
50 Years Ago in TheJournalofPediatrics: Commentary: The Use of Assisted Ventilation in the Therapy of Hyaline Membrane Disease. 61
32040409 2020
23
50 Years Ago in TheJournalofPediatrics: Intermittent Positive Pressure Ventilation in Hyaline Membrane Disease. 61
32040408 2020
24
Etiology, clinical profile and outcome of neonatal pneumothorax in tertiary care center in South India: 13 years experience. 61
32075452 2020
25
Risk Factors of Respiratory Diseases Among Neonates in Neonatal Intensive Care Unit of Qena University Hospital, Egypt. 61
32140431 2020
26
Minimally Invasive Tissue Sampling in Preterm Deaths: A Validation Study. 61
32923527 2020
27
The influence of maternal ethnicity on neonatal respiratory outcome. 61
31123055 2020
28
Comparison of the detection rates for retinopathy of prematurity (ROP) of the 2013 Philippine Academy of Ophthalmology (PAO) Revised Philippine Guidelines and the 2005 PAO-Philippine Pediatric Society (PPS) Guidelines for ROP screening in the Philippine General Hospital: a 5-year review. 61
33094166 2020
29
Fetal, neonatal, and infant death in central China (Hubei): A 16-year retrospective study of forensic autopsy cases. 61
31169678 2019
30
Outcome of Respiratory Distress in Neonates with Bubble CPAP at Neonatal Intensive Care Unit of a Tertiary Hospital. 61
31477940 2019
31
Predictors of Neonatal mortality in Neonatal intensive care unit at referral Hospital in Southern Ethiopia: a retrospective cohort study. 61
30819143 2019
32
Case report of a laryngotracheal reconstruction with anterior and posterior costal cartilage graft and stent placement - Surgical technique. 61
31039513 2019
33
Co-initiation of continuous renal replacement therapy, peritoneal dialysis, and extracorporeal membrane oxygenation in neonatal life-threatening hyaline membrane disease: A case report. 61
30681590 2019
34
Survival and predictors among preterm neonates admitted at University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia. 61
30616641 2019
35
Growth restriction increases the risk of bronchopulmonary dysplasia, death, and sepsis in twins of 30 weeks or less of gestation. 61
31095217 2019
36
Hyaline membrane disease (HMD): an historical and Oslerian perspective. 61
30291319 2018
37
Proportion and factors of death among preterm neonates admitted in University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia. 61
30522518 2018
38
Perinatal outcomes in uncomplicated late preterm pregnancies with borderline oligohydramnios. 61
28782398 2018
39
Isolated neonatal bilateral vocal cord paralysis revealing a unilateral medullary defect: a case report. 61
30413155 2018
40
An autopsy based descriptive study of the spectrum of pulmonary lesions encountered in fetal deaths at a tertiary care center. 61
30303136 2018
41
Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. 61
30289565 2018
42
Outcomes of self-induced late pregnancy termination in women presenting to a tertiary hospital in the Eastern Cape Province, South Africa. 61
30645966 2018
43
A pre-term infant of 32 weeks gestation with congenital tuberculosis treated successfully with antituberculosis chemotherapy. 61
28805143 2018
44
A study of spectrum of pulmonary pathology and expression of thyroid transcription factor-1 during neonatal period. 61
30004050 2018
45
Scenario of Neonatal Respiratory Distress in Tertiary Hospital. 61
29983424 2018
46
Clinicoetiological Pattern and Outcome of Neonates Requiring Mechanical Ventilation: Study in a Tertiary Care Centre. 61
29910548 2018
47
Neonatal respiratory distress syndrome and underlying mechanisms in cloned cattle. 61
29388718 2018
48
Pulmonary atelectasis in newborns with clinically treatable diseases who are on mechanical ventilation: clinical and radiological aspects. 61
29559762 2018
49
Post-discharge body weight and neurodevelopmental outcomes among very low birth weight infants in Taiwan: A nationwide cohort study. 61
29444139 2018
50
Kidneys in 5-year-old preterm-born children: a longitudinal cohort monitoring of renal function. 61
28665930 2017

Variations for Newborn Respiratory Distress Syndrome

ClinVar genetic disease variations for Newborn Respiratory Distress Syndrome:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 BRAF NM_001374258.1(BRAF):c.1622A>G (p.Glu541Gly) SNV Likely pathogenic 13978 rs180177039 GRCh37: 7:140477806-140477806
GRCh38: 7:140778006-140778006
2 ABCC8 NM_000352.6(ABCC8):c.1793G>A (p.Arg598Gln) SNV Likely pathogenic 523361 rs1344172059 GRCh37: 11:17452385-17452385
GRCh38: 11:17430838-17430838
3 ABCC8 NM_000352.6(ABCC8):c.3517G>A (p.Val1173Met) SNV Likely pathogenic 35609 rs141322087 GRCh37: 11:17426099-17426099
GRCh38: 11:17404552-17404552
4 SFTPC NM_001317778.2(SFTPC):c.163C>T (p.Leu55Phe) SNV Likely pathogenic 598978 rs1563221666 GRCh37: 8:22020207-22020207
GRCh38: 8:22162694-22162694
5 ABCA3 NM_001089.3(ABCA3):c.614-2A>G SNV Likely pathogenic 598980 rs773223403 GRCh37: 16:2369843-2369843
GRCh38: 16:2319842-2319842
6 GJB2 NM_004004.6(GJB2):c.488T>C (p.Met163Thr) SNV Likely pathogenic 449488 rs1273330603 GRCh37: 13:20763233-20763233
GRCh38: 13:20189094-20189094
7 DES NM_001927.4(DES):c.407T>A (p.Leu136His) SNV Uncertain significance 44261 rs397516695 GRCh37: 2:220283591-220283591
GRCh38: 2:219418869-219418869
8 ABCA3 NM_001089.3(ABCA3):c.3200G>A (p.Gly1067Glu) SNV Uncertain significance 598979 rs1567339065 GRCh37: 16:2336773-2336773
GRCh38: 16:2286772-2286772

Expression for Newborn Respiratory Distress Syndrome

Search GEO for disease gene expression data for Newborn Respiratory Distress Syndrome.

Pathways for Newborn Respiratory Distress Syndrome

Pathways related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.52 SFTPD SFTPC SFTPB SFTPA2 SFTPA1
2 11.38 SFTPC SFTPA2 SFTPA1
3
Show member pathways
11.22 SFTPD SFTPA2 SFTPA1 SCGB1A1
4 10.94 PCYT1B LPCAT1 CHPT1
5
Show member pathways
10.75 SFTPD SFTPC SFTPB SFTPA2 SFTPA1
6
Show member pathways
10.73 SFTPD SFTPC SFTPB SFTPA2 SFTPA1 ABCA3
7 10.15 PCYT1B CHPT1

GO Terms for Newborn Respiratory Distress Syndrome

Cellular components related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.13 TTN SFTPD SFTPC SFTPB SFTPA2 SFTPA1
2 extracellular space GO:0005615 10.07 SFTPD SFTPC SFTPB SFTPA2 SFTPA1 SCGB1A1
3 endoplasmic reticulum membrane GO:0005789 10.01 SFTPD SFTPC SFTPB SFTPA2 SFTPA1 PCYT1B
4 collagen trimer GO:0005581 9.65 SFTPD SFTPA2 SFTPA1
5 rough endoplasmic reticulum GO:0005791 9.62 SFTPD SFTPA2 SFTPA1 SCGB1A1
6 multivesicular body GO:0005771 9.56 SFTPD SFTPB SFTPA2 SFTPA1
7 multivesicular body lumen GO:0097486 9.46 SFTPC SFTPB
8 alveolar lamellar body GO:0097208 9.33 SFTPC SFTPB ABCA3
9 lamellar body GO:0042599 9.26 SFTPC SFTPB SFTPA2 SFTPA1
10 clathrin-coated endocytic vesicle GO:0045334 9.02 SFTPD SFTPC SFTPB SFTPA2 SFTPA1

Biological processes related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.63 SCGB1A1 GJB2 ABCC8
2 phospholipid biosynthetic process GO:0008654 9.54 PCYT1B LPCAT1 CHPT1
3 toll-like receptor signaling pathway GO:0002224 9.5 SFTPD SFTPA2 SFTPA1
4 thyroid gland development GO:0030878 9.48 NKX2-1 BRAF
5 opsonization GO:0008228 9.43 SFTPA1 CRP
6 phosphatidylcholine biosynthetic process GO:0006656 9.43 PCYT1B LPCAT1 CHPT1
7 cellular protein metabolic process GO:0044267 9.43 SFTPD SFTPC SFTPB SFTPA2 SFTPA1 ABCA3
8 CDP-choline pathway GO:0006657 9.4 PCYT1B CHPT1
9 surfactant homeostasis GO:0043129 9.33 SFTPD LPCAT1 ABCA3
10 respiratory gaseous exchange GO:0007585 9.02 SFTPD SFTPC SFTPB SFTPA2 SFTPA1

Molecular functions related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.02 TTN LPCAT1 GJB2 CRP BRAF

Sources for Newborn Respiratory Distress Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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