MCID: NWB001
MIFTS: 58

Newborn Respiratory Distress Syndrome

Categories: Fetal diseases, Respiratory diseases

Aliases & Classifications for Newborn Respiratory Distress Syndrome

MalaCards integrated aliases for Newborn Respiratory Distress Syndrome:

Name: Newborn Respiratory Distress Syndrome 12 15 17
Hyaline Membrane Disease 12 44 72
Respiratory Distress Syndrome of Newborn 12 33
Pulmonary Hypoperfusion Syndrome of Newborn 12
Neonatal Respiratory Distress Syndrome 12
Respiratory Distress Syndrome, Newborn 72
Pulmonary Hyaline Membrane Disease 12
Hmd - Hyaline Membrane Disease 12
Respiratory Distress Syndrome 72

Classifications:



External Ids:

Disease Ontology 12 DOID:12716
MeSH 44 D006819
SNOMED-CT 68 26168007 46775006
ICD10 33 P22 P22.0 P22.9
UMLS 72 C0020192 C0035220 C0852283

Summaries for Newborn Respiratory Distress Syndrome

Disease Ontology : 12 A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.

MalaCards based summary : Newborn Respiratory Distress Syndrome, also known as hyaline membrane disease, is related to respiratory distress syndrome in premature infants and bronchopulmonary dysplasia, and has symptoms including dyspnea, respiratory distress and apnea. An important gene associated with Newborn Respiratory Distress Syndrome is IGHMBP2 (Immunoglobulin Mu DNA Binding Protein 2), and among its related pathways/superpathways are Transcriptional misregulation in cancer and IL-1 Family Signaling Pathways. The drugs Acetaminophen and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include Lung and Lung, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Newborn Respiratory Distress Syndrome

Diseases related to Newborn Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)
# Related Disease Score Top Affiliating Genes
1 respiratory distress syndrome in premature infants 31.2 SFTPC SFTPB ABCA3
2 bronchopulmonary dysplasia 30.8 SFTPB SCGB1A1 ELANE CXCL8
3 pulmonary immaturity 30.4 SFTPD SFTPC SFTPB
4 perinatal necrotizing enterocolitis 30.0 IL6 IL1B CXCL8
5 funisitis 30.0 IL6 IL1B CXCL8
6 preterm premature rupture of the membranes 30.0 IL6 IL1B CXCL8
7 otitis media 29.9 IL6 IL1B CXCL8
8 placenta disease 29.7 IL6 IL1B CXCL8
9 surfactant dysfunction 29.7 SFTPC SFTPB PLA2G2A ABCA3
10 cytomegalovirus infection 29.6 IL6 IL1B CXCL8
11 meconium aspiration syndrome 29.4 SFTPB SCGB1A1 IL6 CXCL8
12 chorioamnionitis 29.3 IL6 IL1B ELANE CXCL8
13 adult respiratory distress syndrome 29.1 SFTPC SFTPB IL6 ELANE CXCL8
14 bacterial pneumonia 29.1 SFTPD SFTPB IL6 ELANE CXCL8
15 bacterial infectious disease 29.0 IL6 IL1B ELANE CXCL8
16 respiratory failure 28.4 TTN SFTPD SFTPC SFTPB SCGB1A1 IGHMBP2
17 pneumonia 28.2 SFTPD SFTPC SFTPB IL6 IL1B ELANE
18 acute respiratory distress syndrome 27.9 SFTPD SFTPC SFTPB IL6 IL1B ELANE
19 lung disease 27.2 SFTPD SFTPC SFTPB IL6 IL1B ELANE
20 choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction 12.1
21 respiratory distress syndrome, infant 11.9
22 tracheal agenesis 10.7 SFTPD SFTPB
23 paraquat lung 10.6 SFTPB SCGB1A1
24 toxic pneumonitis 10.6 SFTPB SCGB1A1
25 patent ductus arteriosus 1 10.5
26 exudative glomerulonephritis 10.5 IL1B CXCL8
27 interstitial emphysema 10.5
28 pneumothorax 10.5
29 peptic esophagitis 10.4 IL1B CXCL8
30 haemophilus influenzae 10.4 IL1B CXCL8
31 pulmonary alveolar proteinosis 10.4 SFTPD SFTPC SFTPB
32 opisthorchiasis 10.4 IL1B CXCL8
33 cardiac rupture 10.4 ELANE CXCL8
34 crohn's colitis 10.4 IL1B CXCL8
35 autoimmune vasculitis 10.3 IL1B ELANE
36 pulmonary fibrosis 10.3 SFTPD SFTPC IL1B
37 status asthmaticus 10.3 ELANE CXCL8
38 dental pulp disease 10.3 IL1B CXCL8
39 periodontosis 10.3 ELANE CXCL8
40 acute chest syndrome 10.3 PLA2G2A CXCL8
41 streptococcal toxic-shock syndrome 10.3 IL6 CXCL8
42 acute transverse myelitis 10.3 IL6 CXCL8
43 transverse myelitis 10.3 IL6 CXCL8
44 papillary conjunctivitis 10.2 IL6 CXCL8
45 denture stomatitis 10.2 IL6 CXCL8
46 pulmonary emphysema 10.2 SFTPD SFTPC ELANE
47 neonatal respiratory failure 10.2 SFTPC SFTPB ABCA3
48 acute monoblastic leukemia 10.2 IL6 CXCL8
49 pre-eclampsia 10.2
50 periodontitis, chronic 10.2 IL6 IL1B

Graphical network of the top 20 diseases related to Newborn Respiratory Distress Syndrome:



Diseases related to Newborn Respiratory Distress Syndrome

Symptoms & Phenotypes for Newborn Respiratory Distress Syndrome

UMLS symptoms related to Newborn Respiratory Distress Syndrome:


dyspnea, respiratory distress, apnea, hemoptysis, cheyne-stokes respiration, coughing, hoarseness

MGI Mouse Phenotypes related to Newborn Respiratory Distress Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 ABCA3 ELANE IGHMBP2 IL1B IL6 PLG
2 mortality/aging MP:0010768 9.9 ABCA3 ELANE IGHMBP2 IL1B IL6 PLG
3 immune system MP:0005387 9.86 ELANE IL1B IL6 PLG SCGB1A1 SFTPC
4 neoplasm MP:0002006 9.43 ELANE IL1B IL6 PLG SCGB1A1 SFTPC
5 respiratory system MP:0005388 9.23 ABCA3 IGHMBP2 IL6 PLG SCGB1A1 SFTPB

Drugs & Therapeutics for Newborn Respiratory Distress Syndrome

Drugs for Newborn Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 409)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
3
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
4
Clonidine Approved Phase 4 4205-90-7 2803
5
Nefopam Approved, Investigational Phase 4 13669-70-0
6
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
7
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
8
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
9
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
10
Remifentanil Approved Phase 4 132875-61-7 60815
11
Sodium citrate Approved, Investigational Phase 4 68-04-2
12
Metformin Approved Phase 4 657-24-9 4091 14219
13
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
14
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
15
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
16
Caffeine Approved Phase 4 58-08-2 2519
17
Zinc Approved, Investigational Phase 4 7440-66-6 32051
18
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
19
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
20
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
21 Poractant alfa Approved Phase 4 129069-19-8
22
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
23 Beractant Approved Phase 4 108778-82-1
24
Budesonide Approved Phase 4 51333-22-3 63006 5281004
25
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
26
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
27
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
28
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
29
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
30
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
31
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
32
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
33
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
34
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
35
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7
36 Sivelestat Investigational Phase 4 127373-66-4
37
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
38 Antipyretics Phase 4
39 Anesthetics, Local Phase 4
40 Hydrocortisone-17-butyrate Phase 4
41 Hydrocortisone 17-butyrate 21-propionate Phase 4
42 Hydrocortisone hemisuccinate Phase 4
43 Serine Proteinase Inhibitors Phase 4
44 Antiviral Agents Phase 4
45 Neuromuscular Nondepolarizing Agents Phase 4
46 N-monoacetylcystine Phase 4
47 Antidotes Phase 4
48 cysteine Phase 4
49 Expectorants Phase 4
50 carnitine Phase 4

Interventional clinical trials:

(show top 50) (show all 1247)
# Name Status NCT ID Phase Drugs
1 Assessment of the Cerebral Tissue Oxygenation and the Bioelectrical Brain Activity of Preterm Newborns During Administration of Two Different Surfactant Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
2 Effect of Treatment With Stress-Doses Glucocorticoid on Mortality in Patients With ARDS and Relative Adrenal Insufficiency Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
3 Efficacy Evaluation of Surfactant Administration for Respiratory Distress Syndrome Treatment Via Laryngeal Mask Airway. A Randomized Controlled Trial Unknown status NCT01173237 Phase 4
4 Propofol and Remifentanil Versus Midazolam and Remifentanil as Premedication Allowing Very Early Extubation After Surfactant Treatment in Preterm Neonates With Respiratory Distress Syndrome Unknown status NCT00797160 Phase 4 propofol
5 Comparative Trial of Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
6 Early Bubble CPAP (EBCPAP) in Very Low Birth Weight Infants (VLBWI) Unknown status NCT00368680 Phase 4
7 Effects of NMBA on the Alteration of Transpulmonary Pressures at the Early Phase of ARDS Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
8 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
9 Prevention of Chronic Lung Disease (CLD) in Preterm Infants -A New Therapeutic Regimen Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
10 THE EFFECT OF SUSTAINED LUNG INFLATION MANEUVER APPLIED THROUGH NASAL PRONG ON EARLY AND LATE RESPIRATORY MORBIDITIES IN PRETERM INFANTS Unknown status NCT02887924 Phase 4
11 Early Administration of Surfactant in Spontaneous Breathing (TAKE CARE) Versus InSurE (Intubation, Surfactant, Extubation) : A Pilot Study Unknown status NCT01329432 Phase 4
12 the Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
13 Functional Residual Capacity Guided Alveolar Recruitment Strategy in Patients With Acute Respiratory Failure After Cardiac Surgery Unknown status NCT01280019 Phase 4
14 The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
15 Non-Invasive Positive Pressure Mask Ventilation vs Extrathoracic Biphasic Cuirass Ventilation in Patients With Acute Respiratory Failure: A Randomized Prospective Study. Unknown status NCT00331656 Phase 4
16 A Multicentre, Randomized, Clinical Trial of Noninvasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure - NINAVAPed Protocol Unknown status NCT01873521 Phase 4
17 A MULTICENTER, RANDOMIZED, CONTROLLED STUDY OF EPIDURAL ANALGESIA FOR SEVERE ACUTE PANCREATITIS Unknown status NCT02126332 Phase 4
18 An International, Open, Randomized, Controlled Study to Evaluate the Efficacy of Combining Prophylactic Curosurf® With Early Nasal CPAP Versus Early Nasal CPAP Alone in Very Preterm Infants at Risk of Respiratory Distress Syndrome Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
19 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
20 Comparative Study of the Use of Remifentanil Versus Morphine for Sedation and Analgesia of Premature Neonates During Mechanical Ventilation in the Treatment of Respiratory Distress Syndrome (RDS) Completed NCT00391105 Phase 4 Remifentanil
21 Effects of Bolus Surfactant Therapy on Serial Peripheral Perfusion Index and Tissue Carbon Monoxide Measurements in Preterm Infants With Severe Respiratory Distress Syndrome Completed NCT01923844 Phase 4 exogenous surfactant
22 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
23 Effect of Early 48-hour Sevoflurane Inhalation on Gas Exchange and Inflammation in Patients Presenting With Acute Respiratory Distress Syndrome (ARDS) : a Monocentric, Prospective, Randomized Study. Completed NCT02166853 Phase 4 sevoflurane;midazolam
24 Corticosteroid Mediates Acute Respiratory Distress Syndrome Via NLRP3 Inflammasome Signaling Pathway Completed NCT02819453 Phase 4 Methylprednisolone
25 Effects Of A Recruitment Maneuver On Plasma Levels of sRAGE, The Soluble Form of The Receptor For Advanced Glycation End Products, In Patients With Diffuse Acute Respiratory Distress Syndrome (ARDS) Completed NCT01600651 Phase 4
26 Rescue Surfactant for Respiratory Distress Syndrome (RDS) in Newborns: Comparing Efficacy of Delivery Via Laryngeal Mask Airway to Delivery by Endotracheal Intubation Completed NCT01042600 Phase 4
27 The Study of Pharmacokinetics and Pharmacodynamics of a Loading Dose Cisatracurium in Critically Ill Patients Completed NCT03337373 Phase 4 cisatracurium
28 A Comparative, Randomised Controlled Trial for Evaluating the Efficacy of Dexamethasone in the Treatment of Patients With Acute Respiratory Distress Syndrome Completed NCT01731795 Phase 4 Dexamethasone
29 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
30 Efficacy and Safety of Sivelestat Sodium Hydrate in Acute Lung Injury Associated With Systemic Inflammatory Response Syndrome, Compared With the Conventional Treatment in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
31 Non-Positive Pressure Ventilation in Hypoxemic Patients. A Randomized Study Completed NCT00925860 Phase 4
32 Multi-dose Vitamin D Supplementation in Preterm Infants Completed NCT02941185 Phase 4 Devit-3 Oral Drop
33 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
34 Follow-Up at 6 Years of a Cohort of Children Born Very Prematurely With Respiratory and Neurodevelopmental Impact of Early Treatment With Inhaled Nitric Oxide Completed NCT00390065 Phase 4 Nitric Oxide
35 A Randomized Double-Blinded Study Comparing the Impact of One Versus Two Courses of Antenatal Steroids on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
36 Influence of N-Acetylcysteine on Morbidity, Oxygenation and Cytokine Levels in Partial or Total Esophagectomy for Cancer. A Multicenter, Prospective, Randomised Double Blind, Placebo-controlled Study Completed NCT00512265 Phase 4 n-acetylcysteine;250mL glucose 5%
37 Supportive Measures in Treatment of Aluminum Phosphide Poisoning as a Trial to Reduce Mortality at Assiut University Hospital Completed NCT03879356 Phase 4 N-acetyl cysteine
38 Effect of Steroids Given Over 24 Hours on Cytokine Release and Urinary Desmosine Levels in Patients Undergoing Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
39 ON Pump vs OFF Pump Myocardial Revascularization in High Risk Patients: a Randomized Study Completed NCT01290952 Phase 4
40 A Randomized Trial to Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates in Developing Countries Completed NCT01403623 Phase 4
41 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation: The PrePARE Trial Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
42 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients. PILOT: The TRAUMOX Trial Completed NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
43 Effects of Adding L‑Carnitine With Dexamethasone on Respiratory Distress Syndrome Development in Preterm Infants Recruiting NCT03630367 Phase 4 Dexamethasone;L-Carnitine 1G/5mL Injection
44 Effect of Inhalation Sedation With Sevoflurane Compared With Propofol on the Sepsis-related Acute Respiratory Distress Syndrome (ARDS) Course. Recruiting NCT04014218 Phase 4 Inhalation Sedation;Intravenous Sedation
45 Efficacy of Adding Budesonide to Poractant Alfa to Prevent Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome. Recruiting NCT03521063 Phase 4 Budesonide;Poractant Alfa;Saline
46 Efficacy of Rescue Surfactant Delivery Via Endotracheal Intubation (INSURE Technique) Versus Laryngeal Mask Airway (LMA) for Respiratory Distress Syndrome (RDS) in Preterm Neonates Recruiting NCT02164734 Phase 4 remifentanil
47 The Effect of Co-administered β-Carotene, Vitamin D3, Zinc and Antenatal Steroid Therapy on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone
48 The Effect of Maternal Antenatal Steroid Administration on the Blood Flow Through the Pulmonary Artery in the Term Fetus; a Randomized Control Double Blinded Study Recruiting NCT02978976 Phase 4 Betamethasone;saline
49 Randomised Clinical Trial: Dexmedetomidine Versus Standard Clinical Practice During Non Invasive Mechanical Ventilation Recruiting NCT02958150 Phase 4 Dexmedetomidine
50 Reducing the Need for Intensive Care Unit in Hospitalized Patients With Early Respiratory Failure Using the Non-invasive Ventilation Technique. A Multicentre Randomized Study. Recruiting NCT01572337 Phase 4

Search NIH Clinical Center for Newborn Respiratory Distress Syndrome

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Albumin Human, USP
ALBUMIN,AGGREGATED
ALBUMIN,EGG
ALBUMIN,HUMAN INJ
ALBUMIN,MICROSPHERE HUMAN SERUM
beractant
Beractant
Calfactant
Colfosceril
colfosceril palmitate
Epinephrine
Nitric Oxide
Poractant alfa
Poractant alfa

Cochrane evidence based reviews: hyaline membrane disease

Genetic Tests for Newborn Respiratory Distress Syndrome

Anatomical Context for Newborn Respiratory Distress Syndrome

MalaCards organs/tissues related to Newborn Respiratory Distress Syndrome:

41
Lung, Fetal Lung, Testes, Heart, Neutrophil, Liver, Bone
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Newborn Respiratory Distress Syndrome:
# Tissue Anatomical CompartmentCell Relevance
1 Lung Pulmonary Capillary Plexus Affected by disease
2 Lung Alveoli Alveolar Epithelial Type 1 Cells Affected by disease, potential therapeutic candidate
3 Lung Alveoli Alveolar Epithelial Type 2 Cells Affected by disease, potential therapeutic candidate

Publications for Newborn Respiratory Distress Syndrome

Articles related to Newborn Respiratory Distress Syndrome:

(show top 50) (show all 1841)
# Title Authors PMID Year
1
Population and disease-based prevalence of the common mutations associated with surfactant deficiency. 9 38
18317237 2008
2
Fetal, neonatal, and infant death in central China (Hubei): A 16-year retrospective study of forensic autopsy cases. 38
31169678 2019
3
The influence of maternal ethnicity on neonatal respiratory outcome. 38
31123055 2019
4
Predictors of Neonatal mortality in Neonatal intensive care unit at referral Hospital in Southern Ethiopia: a retrospective cohort study. 38
30819143 2019
5
Survival and predictors among preterm neonates admitted at University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia. 38
30616641 2019
6
Case report of a laryngotracheal reconstruction with anterior and posterior costal cartilage graft and stent placement - Surgical technique. 38
31039513 2019
7
Co-initiation of continuous renal replacement therapy, peritoneal dialysis, and extracorporeal membrane oxygenation in neonatal life-threatening hyaline membrane disease: A case report. 38
30681590 2019
8
Growth restriction increases the risk of bronchopulmonary dysplasia, death, and sepsis in twins of 30 weeks or less of gestation. 38
31095217 2019
9
Proportion and factors of death among preterm neonates admitted in University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia. 38
30522518 2018
10
Perinatal outcomes in uncomplicated late preterm pregnancies with borderline oligohydramnios. 38
28782398 2018
11
Hyaline membrane disease (HMD): an historical and Oslerian perspective. 38
30291319 2018
12
Isolated neonatal bilateral vocal cord paralysis revealing a unilateral medullary defect: a case report. 38
30413155 2018
13
Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. 38
30289565 2018
14
An autopsy based descriptive study of the spectrum of pulmonary lesions encountered in fetal deaths at a tertiary care center. 38
30303136 2018
15
Outcomes of self-induced late pregnancy termination in women presenting to a tertiary hospital in the Eastern Cape Province, South Africa. 38
30645966 2018
16
A pre-term infant of 32 weeks gestation with congenital tuberculosis treated successfully with antituberculosis chemotherapy. 38
28805143 2018
17
A study of spectrum of pulmonary pathology and expression of thyroid transcription factor-1 during neonatal period. 38
30004050 2018
18
Scenario of Neonatal Respiratory Distress in Tertiary Hospital. 38
29983424 2018
19
Clinicoetiological Pattern and Outcome of Neonates Requiring Mechanical Ventilation: Study in a Tertiary Care Centre. 38
29910548 2018
20
Neonatal respiratory distress syndrome and underlying mechanisms in cloned cattle. 38
29388718 2018
21
Pulmonary atelectasis in newborns with clinically treatable diseases who are on mechanical ventilation: clinical and radiological aspects. 38
29559762 2018
22
Post-discharge body weight and neurodevelopmental outcomes among very low birth weight infants in Taiwan: A nationwide cohort study. 38
29444139 2018
23
Kidneys in 5-year-old preterm-born children: a longitudinal cohort monitoring of renal function. 38
28665930 2017
24
[Congenital cytomegalovirus infection manifesting as neonatal respiratory distress in an HIV-exposed uninfected newborn]. 38
28734808 2017
25
Maternal and neonatal outcomes in twin and triplet gestations in Western Saudi Arabia. 38
28578447 2017
26
Postoperative complications following neonatal and infant surgery: Common events and predictive factors. 38
27671979 2017
27
Prevalence of Lung Lesions at Autopsy: A Histopathological Study. 38
28658765 2017
28
Different ventilation modes combined with ambroxol in the treatment of respiratory distress syndrome in premature infants. 38
28352342 2017
29
[Perinatal Outcome in Relation to Chorionicity in Twin Pregnancy]. 38
28501032 2017
30
Probucol attenuates hyperoxia-induced lung injury in mice. 38
28384256 2017
31
Neonatal Ureaplasma urealyticum colonization increases pulmonary and cerebral morbidity despite treatment with macrolide antibiotics. 38
26518581 2016
32
Outcome of Twin Deliveries at a Tertiary Care Centre of Eastern Nepal. 38
27885296 2016
33
Neonatal respiratory distress in a reference neonatal unit in Cameroon: an analysis of prevalence, predictors, etiologies and outcomes. 38
27642489 2016
34
Maternal Risk Factors and Outcomes of Umbilical Cord Prolapse: A Population-Based Study. 38
26872752 2016
35
Institution Based Prospective Cross-Sectional Study on Patterns of Neonatal Morbidity at Gondar University Hospital Neonatal Unit, North-West Ethiopia. 38
26949319 2016
36
LARS2 Variants Associated with Hydrops, Lactic Acidosis, Sideroblastic Anemia, and Multisystem Failure. 38
26537577 2016
37
Formation of Hyaline Membranes in the Lungs of Albino Rat as a Result of Exposure to Bleomycin During the Neonatal Period. 38
26742747 2016
38
Newborn Respiratory Distress. 38
26760414 2015
39
Hospital admission due to respiratory viral infections in moderate preterm, late preterm and term infants during their first year of life. 38
25456533 2015
40
Surfactant Protein B Deficiency Caused by Homozygous C248X Mutation-A Case Report and Review of the Literature. 38
26199800 2015
41
Procalcitonin as a marker of respiratory disorder in neonates. 38
25223367 2015
42
Impact of the systematic introduction of low-cost bubble nasal CPAP in a NICU of a developing country: a prospective pre- and post-intervention study. 38
25885437 2015
43
[Very preterm births in French Polynesia: update and proposal for follow-up]. 38
25554672 2015
44
50 years ago in the Journal of Pediatrics: surface properties and lipids from lungs of infants with hyaline membrane disease. 38
25620514 2015
45
Investigating the effects of the neonatal factors and therapeutic modalities on neonatal mortality in neonatal intensive care unit of Shahid Motahhari Hospital, Urmia. 38
25400676 2014
46
Intra-hospital mortality among neonates transported by ambulance in Colombia. 38
24612475 2014
47
A Comparison of the Short-term Morbidity and Mortality Between Late Preterm and Term Newborns. 38
25142470 2014
48
Diagnostic value of gastric shake test for hyaline membrane disease in preterm infant. 38
25114671 2014
49
Maternal and fetal outcomes of triplet gestation in a tertiary hospital in oman. 38
24790743 2014
50
Low risk, but not no risk, of umbilical hernia complications requiring acute surgery in childhood. 38
24372946 2014

Variations for Newborn Respiratory Distress Syndrome

ClinVar genetic disease variations for Newborn Respiratory Distress Syndrome:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 IGHMBP2 NM_002180.2(IGHMBP2): c.92G> A (p.Trp31Ter) single nucleotide variant Pathogenic rs863224880 11:68673542-68673542 11:68906074-68906074
2 SFTPC NM_003018.4(SFTPC): c.163C> T (p.Leu55Phe) single nucleotide variant Likely pathogenic 8:22020207-22020207 8:22162694-22162694
3 ABCA3 NM_001089.3(ABCA3): c.614-2A> G single nucleotide variant Likely pathogenic 16:2369843-2369843 16:2319842-2319842
4 SYT2 NM_177402.5(SYT2): c.1084_1089del (p.Tyr362_Asp363del) deletion Likely pathogenic rs1057518805 1:202566056-202566061 1:202596928-202596933
5 GJB2 NM_004004.6(GJB2): c.488T> C (p.Met163Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs1273330603 13:20763233-20763233 13:20189094-20189094
6 DES NM_001927.4(DES): c.407T> A (p.Leu136His) single nucleotide variant Uncertain significance rs397516695 2:220283591-220283591 2:219418869-219418869
7 PMP22 NM_000304.4(PMP22): c.422T> G (p.Val141Gly) single nucleotide variant Uncertain significance rs1057518804 17:15134295-15134295 17:15230978-15230978
8 ABCA3 NM_001089.3(ABCA3): c.3200G> A (p.Gly1067Glu) single nucleotide variant Uncertain significance 16:2336773-2336773 16:2286772-2286772

Expression for Newborn Respiratory Distress Syndrome

Search GEO for disease gene expression data for Newborn Respiratory Distress Syndrome.

Pathways for Newborn Respiratory Distress Syndrome

Pathways related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1 12.07 IL6 ELANE CXCL8
2
Show member pathways
12.03 IL6 IL1B CXCL8
3 11.98 IL6 IL1B CXCL8
4
Show member pathways
11.86 PLG IL6 IL1B
5
Show member pathways
11.84 SFTPD IL6 IL1B CXCL8
6 11.81 IL6 IL1B CXCL8
7 11.77 IL6 IL1B CXCL8
8 11.73 IL6 IL1B CXCL8
9 11.73 IL6 IL1B CXCL8
10
Show member pathways
11.68 SFTPD SFTPC SFTPB
11 11.67 IL6 IL1B CXCL8
12 11.64 PLA2G2A IL6 IL1B CXCL8
13 11.6 IL6 IL1B CXCL8
14 11.55 IL6 IL1B CXCL8
15
Show member pathways
11.45 IL6 IL1B CXCL8
16 11.38 IL6 IL1B CXCL8
17 11.3 IL6 IL1B CXCL8
18 11.27 IL6 IL1B CXCL8
19 11.23 PLG IL6 ELANE
20 11.07 IL6 IL1B
21 11.06 SFTPC IL6 IL1B CXCL8
22 11.02 IL6 IL1B CXCL8
23 10.87 IL6 CXCL8
24
Show member pathways
10.73 SFTPD SFTPC SFTPB
25
Show member pathways
10.56 SFTPD SFTPC SFTPB ABCA3

GO Terms for Newborn Respiratory Distress Syndrome

Cellular components related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TTN SFTPD SFTPC SFTPB SCGB1A1 PLG
2 secretory granule GO:0030141 9.46 SCGB1A1 PLA2G2A IL1B ELANE
3 multivesicular body GO:0005771 9.43 SFTPD SFTPB
4 clathrin-coated endocytic vesicle GO:0045334 9.43 SFTPD SFTPC SFTPB
5 lamellar body GO:0042599 9.4 SFTPC SFTPB
6 multivesicular body lumen GO:0097486 9.37 SFTPC SFTPB
7 extracellular space GO:0005615 9.36 SFTPD SFTPC SFTPB SCGB1A1 PLG PLA2G2A
8 alveolar lamellar body GO:0097208 9.32 SFTPB ABCA3

Biological processes related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.73 PLG IL6 IL1B CXCL8
2 response to lipopolysaccharide GO:0032496 9.69 SCGB1A1 IL1B ELANE
3 cellular response to lipopolysaccharide GO:0071222 9.67 IL6 IL1B CXCL8
4 negative regulation of neurogenesis GO:0050768 9.48 IL6 IL1B
5 positive regulation of glial cell proliferation GO:0060252 9.4 IL6 IL1B
6 positive regulation of neuroinflammatory response GO:0150078 9.37 IL6 IL1B
7 respiratory gaseous exchange GO:0007585 9.33 SFTPD SFTPC SFTPB
8 negative regulation of chemokine biosynthetic process GO:0045079 9.26 IL6 ELANE
9 positive regulation of neutrophil chemotaxis GO:0090023 9.16 CXCL8
10 response to glucocorticoid GO:0051384 9.13 SCGB1A1 IL6 ABCA3
11 cellular protein metabolic process GO:0044267 9.1 SFTPD SFTPC SFTPB PLG IL6 ABCA3
12 response to ozone GO:0010193 9.02 SCGB1A1

Sources for Newborn Respiratory Distress Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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