Newborn Respiratory Distress Syndrome

Categories: Fetal diseases, Respiratory diseases

Aliases & Classifications for Newborn Respiratory Distress Syndrome

MalaCards integrated aliases for Newborn Respiratory Distress Syndrome:

Name: Newborn Respiratory Distress Syndrome 12 15 17
Hyaline Membrane Disease 12 43 71
Respiratory Distress Syndrome of Newborn 12 32
Pulmonary Hypoperfusion Syndrome of Newborn 12
Neonatal Respiratory Distress Syndrome 12
Respiratory Distress Syndrome, Newborn 71
Pulmonary Hyaline Membrane Disease 12
Hmd - Hyaline Membrane Disease 12
Respiratory Distress Syndrome 71


External Ids:

Disease Ontology 12 DOID:12716
MeSH 43 D006819
ICD10 32 P22 P22.0 P22.9
UMLS 71 C0020192 C0035220 C0852283

Summaries for Newborn Respiratory Distress Syndrome

Disease Ontology : 12 A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.

MalaCards based summary : Newborn Respiratory Distress Syndrome, also known as hyaline membrane disease, is related to respiratory distress syndrome in premature infants and bronchopulmonary dysplasia, and has symptoms including dyspnea, hemoptysis and apnea. An important gene associated with Newborn Respiratory Distress Syndrome is IGHMBP2 (Immunoglobulin Mu DNA Binding Protein 2), and among its related pathways/superpathways are Toll Comparative Pathway and Bacterial infections in CF airways. The drugs Hydrocortisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include Lung, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Newborn Respiratory Distress Syndrome

Diseases related to Newborn Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 292)
# Related Disease Score Top Affiliating Genes
1 respiratory distress syndrome in premature infants 31.4 SFTPC SFTPB NKX2-1 ABCA3
2 bronchopulmonary dysplasia 31.4 SFTPB SCGB1A1 FGF7 ELANE CXCL8
3 interstitial emphysema 31.1 TTN SFTPD SFTPC SFTPB ABCA3
4 perinatal necrotizing enterocolitis 30.8 IL6 IL1B CXCL8
5 funisitis 30.8 IL6 IL1B CXCL8
6 preterm premature rupture of the membranes 30.8 IL6 IL1B CXCL8
7 pulmonary edema 30.8 SCGB1A1 IL1B FGF7 CXCL8
8 disseminated intravascular coagulation 30.7 PLG IL6 ELANE
9 chorioamnionitis 30.6 IL6 IL1B ELANE CXCL8
10 cerebral palsy 30.5 NKX2-1 IL6 IL1B CXCL8
11 cytomegalovirus infection 30.5 IL6 IL1B CXCL8
12 surfactant dysfunction 30.5 SFTPC SFTPB PLA2G2A ABCA3
13 bronchiolitis 30.4 SFTPD SCGB1A1 IL6 CXCL8
14 placenta disease 30.4 IL6 IL1B CXCL8
15 rhinitis 30.2 SCGB1A1 NR3C1 IL6 IL1B CXCL8
16 otitis media 30.2 SFTPA2 PLG IL6 IL1B ELANE CXCL8
17 pulmonary hypertension 30.2 SFTPC PLG IL6 IL1B ELANE CXCL8
18 pulmonary immaturity 30.1 SFTPD SFTPC SFTPB SFTPA2 ABCA3
19 bacterial infectious disease 30.1 MIF IL6 IL1B ELANE CXCL8
20 bacterial pneumonia 30.1 SFTPD SFTPB SCGB1A1 IL6 IL1B ELANE
21 pneumonia 30.0 SFTPD SFTPC SFTPB SCGB1A1 IL6 IL1B
22 meconium aspiration syndrome 29.9 TTN SFTPB SCGB1A1 PLA2G2A IL6 CXCL8
23 adult respiratory distress syndrome 29.9 SFTPD SFTPC SFTPB IL6 IL1B FGF7
24 respiratory failure 29.4 TTN SFTPD SFTPC SFTPB SCGB1A1 NKX2-1
25 lung disease 28.8 SFTPD SFTPC SFTPB SFTPA2 SCGB1A1 NKX2-1
26 choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction 12.1
27 respiratory distress syndrome, infant 11.9
28 tracheal agenesis 10.7 SFTPD SFTPB
29 paraquat lung 10.7 SFTPB SCGB1A1
30 idiopathic anterior uveitis 10.6 IL6 CXCL8
31 streptococcal toxic-shock syndrome 10.6 IL6 CXCL8
32 acute transverse myelitis 10.6 IL6 CXCL8
33 toxic pneumonitis 10.6 SFTPB SCGB1A1
34 pulmonary fibrosis, familial 10.6 SFTPC SFTPA2
35 ventilation pneumonitis 10.6 SFTPB ABCA3
36 surfactant metabolism dysfunction, pulmonary, 1 10.6 SFTPB ABCA3
37 bagassosis 10.6 IL1B CXCL8
38 prosthetic joint infection 10.6 IL6 IL1B
39 cryptogenic organizing pneumonia 10.6 SFTPD SFTPC CXCL8
40 ligneous conjunctivitis 10.6 PLG ELANE
41 periodontitis, chronic 10.6 IL6 IL1B
42 localized pulmonary fibrosis 10.6 SFTPD IL1B
43 viral pneumonia 10.5 SFTPD IL6 CXCL8
44 fuchs' heterochromic uveitis 10.5 IL6 CXCL8
45 eosinophilic pneumonia 10.5 SFTPD IL6 CXCL8
46 recurrent corneal erosion 10.5 IL6 IL1B CXCL8
47 chlamydia pneumonia 10.5 IL6 IL1B CXCL8
48 chlamydia 10.5 IL6 IL1B CXCL8
49 peptic esophagitis 10.5 IL6 IL1B CXCL8
50 uremic pruritus 10.5 IL6 IL1B

Graphical network of the top 20 diseases related to Newborn Respiratory Distress Syndrome:

Diseases related to Newborn Respiratory Distress Syndrome

Symptoms & Phenotypes for Newborn Respiratory Distress Syndrome

UMLS symptoms related to Newborn Respiratory Distress Syndrome:

dyspnea, hemoptysis, apnea, respiratory distress, cheyne-stokes respiration, coughing, hoarseness

MGI Mouse Phenotypes related to Newborn Respiratory Distress Syndrome:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 ABCA3 ELANE FGF7 IGHMBP2 IL1B IL6
2 immune system MP:0005387 10 ELANE FGF7 IL1B IL6 MIF NR3C1
3 mortality/aging MP:0010768 9.97 ABCA3 ELANE IGHMBP2 IL1B IL6 NKX2-1
4 neoplasm MP:0002006 9.56 ELANE IL1B IL6 MIF NKX2-1 PLG
5 respiratory system MP:0005388 9.32 ABCA3 IGHMBP2 IL6 NKX2-1 NR3C1 PLG

Drugs & Therapeutics for Newborn Respiratory Distress Syndrome

Drugs for Newborn Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 476)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
Metformin Approved Phase 4 657-24-9 14219 4091
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
Caffeine Approved Phase 4 58-08-2 2519
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Sodium citrate Approved, Investigational Phase 4 68-04-2
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 27284 23925
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
Remifentanil Approved Phase 4 132875-61-7 60815
Hydroxychloroquine Approved Phase 4 118-42-3 3652
Acetaminophen Approved Phase 4 103-90-2 1983
Zinc Approved, Investigational Phase 4 7440-66-6 32051
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
20 Poractant alfa Approved Phase 4 129069-19-8
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
22 Beractant Approved Phase 4 108778-82-1
Budesonide Approved Phase 4 51333-22-3 63006 5281004
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7
29 Sivelestat Investigational Phase 4 127373-66-4
BCG vaccine Investigational Phase 4
Camostat Experimental Phase 4 59721-28-7
32 Hydrocortisone 17-butyrate 21-propionate Phase 4
33 Hydrocortisone hemisuccinate Phase 4
34 Hypoglycemic Agents Phase 4
35 insulin Phase 4
36 Insulin, Globin Zinc Phase 4
37 Antidotes Phase 4
38 Expectorants Phase 4
39 N-monoacetylcystine Phase 4
40 retinol Phase 4
41 Retinol palmitate Phase 4
42 Excitatory Amino Acid Antagonists Phase 4
43 Anesthetics, Dissociative Phase 4
44 Anesthetics, General Phase 4
45 Anesthetics, Intravenous Phase 4
46 Neuromuscular Blocking Agents Phase 4
47 Central Nervous System Stimulants Phase 4
48 Adjuvants, Immunologic Phase 4
49 Tin Fluorides Phase 4
50 Citrate Phase 4

Interventional clinical trials:

(show top 50) (show all 1569)
# Name Status NCT ID Phase Drugs
1 Effect of Treatment With Stress-Doses Glucocorticoid on Mortality in Patients With ARDS and Relative Adrenal Insufficiency Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
2 Efficacy Evaluation of Surfactant Administration for Respiratory Distress Syndrome Treatment Via Laryngeal Mask Airway. A Randomized Controlled Trial Unknown status NCT01173237 Phase 4
3 Propofol and Remifentanil Versus Midazolam and Remifentanil as Premedication Allowing Very Early Extubation After Surfactant Treatment in Preterm Neonates With Respiratory Distress Syndrome Unknown status NCT00797160 Phase 4 propofol
4 Comparative Trial of Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
5 Early Bubble CPAP (EBCPAP) in Very Low Birth Weight Infants (VLBWI) Unknown status NCT00368680 Phase 4
6 Effects of NMBA on the Alteration of Transpulmonary Pressures at the Early Phase of ARDS Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
7 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
8 Prevention of Chronic Lung Disease (CLD) in Preterm Infants -A New Therapeutic Regimen Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
10 The Effect of Maternal Antenatal Steroid Administration on the Blood Flow Through the Pulmonary Artery in the Term Fetus; a Randomized Control Double Blinded Study Unknown status NCT02978976 Phase 4 Betamethasone;saline
11 Early Administration of Surfactant in Spontaneous Breathing (TAKE CARE) Versus InSurE (Intubation, Surfactant, Extubation) : A Pilot Study Unknown status NCT01329432 Phase 4
12 Functional Residual Capacity Guided Alveolar Recruitment Strategy in Patients With Acute Respiratory Failure After Cardiac Surgery Unknown status NCT01280019 Phase 4
13 the Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
14 The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
15 A Multicentre, Randomized, Clinical Trial of Noninvasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure - NINAVAPed Protocol Unknown status NCT01873521 Phase 4
16 An International, Open, Randomized, Controlled Study to Evaluate the Efficacy of Combining Prophylactic Curosurf® With Early Nasal CPAP Versus Early Nasal CPAP Alone in Very Preterm Infants at Risk of Respiratory Distress Syndrome Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
17 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
18 Assessment of the Cerebral Tissue Oxygenation and the Bioelectrical Brain Activity of Preterm Newborns During Administration of Two Different Surfactant Completed NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
19 Comparative Study of the Use of Remifentanil Versus Morphine for Sedation and Analgesia of Premature Neonates During Mechanical Ventilation in the Treatment of Respiratory Distress Syndrome (RDS) Completed NCT00391105 Phase 4 Remifentanil
20 Effects of Bolus Surfactant Therapy on Serial Peripheral Perfusion Index and Tissue Carbon Monoxide Measurements in Preterm Infants With Severe Respiratory Distress Syndrome Completed NCT01923844 Phase 4 exogenous surfactant
21 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
22 Effect of Early 48-hour Sevoflurane Inhalation on Gas Exchange and Inflammation in Patients Presenting With Acute Respiratory Distress Syndrome (ARDS) : a Monocentric, Prospective, Randomized Study. Completed NCT02166853 Phase 4 sevoflurane;midazolam
23 Corticosteroid Mediates Acute Respiratory Distress Syndrome Via NLRP3 Inflammasome Signaling Pathway Completed NCT02819453 Phase 4 Methylprednisolone
24 Effects Of A Recruitment Maneuver On Plasma Levels of sRAGE, The Soluble Form of The Receptor For Advanced Glycation End Products, In Patients With Diffuse Acute Respiratory Distress Syndrome (ARDS) Completed NCT01600651 Phase 4
25 Rescue Surfactant for Respiratory Distress Syndrome (RDS) in Newborns: Comparing Efficacy of Delivery Via Laryngeal Mask Airway to Delivery by Endotracheal Intubation Completed NCT01042600 Phase 4
26 The Study of Pharmacokinetics and Pharmacodynamics of a Loading Dose Cisatracurium in Critically Ill Patients Completed NCT03337373 Phase 4 cisatracurium
27 A Comparative, Randomised Controlled Trial for Evaluating the Efficacy of Dexamethasone in the Treatment of Patients With Acute Respiratory Distress Syndrome Completed NCT01731795 Phase 4 Dexamethasone
28 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
29 Efficacy and Safety of Sivelestat Sodium Hydrate in Acute Lung Injury Associated With Systemic Inflammatory Response Syndrome, Compared With the Conventional Treatment in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
30 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
31 Follow-Up at 6 Years of a Cohort of Children Born Very Prematurely With Respiratory and Neurodevelopmental Impact of Early Treatment With Inhaled Nitric Oxide Completed NCT00390065 Phase 4 Nitric Oxide
32 Multi-dose Vitamin D Supplementation in Preterm Infants Completed NCT02941185 Phase 4 Devit-3 Oral Drop
33 Influence of N-Acetylcysteine on Morbidity, Oxygenation and Cytokine Levels in Partial or Total Esophagectomy for Cancer. A Multicenter, Prospective, Randomised Double Blind, Placebo-controlled Study Completed NCT00512265 Phase 4 n-acetylcysteine;250mL glucose 5%
34 A Randomized Double-Blinded Study Comparing the Impact of One Versus Two Courses of Antenatal Steroids on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
35 ON Pump vs OFF Pump Myocardial Revascularization in High Risk Patients: a Randomized Study Completed NCT01290952 Phase 4
36 Effect of Steroids Given Over 24 Hours on Cytokine Release and Urinary Desmosine Levels in Patients Undergoing Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
37 Supportive Measures in Treatment of Aluminum Phosphide Poisoning as a Trial to Reduce Mortality at Assiut University Hospital Completed NCT03879356 Phase 4 N-acetyl cysteine
38 A Randomized Trial to Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates in Developing Countries Completed NCT01403623 Phase 4
39 Effect of Adding Metformin to Insulin Therapy in Pregnant Women With Type I Diabetes as Regards Pregnancy Outcome Completed NCT03928340 Phase 4 Metformin;Insulin
40 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients. PILOT: The TRAUMOX Trial Completed NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
41 Lipid Ibuprofen Versus Standard of Care for Acute Hypoxemic Respiratory Failure Due to COVID-19: a Multicentre, Randomised, Controlled Trial Recruiting NCT04334629 Phase 4 Ibuprofen
42 Effect of Inhalation Sedation With Sevoflurane Compared With Propofol on the Sepsis-related Acute Respiratory Distress Syndrome (ARDS) Course. Recruiting NCT04014218 Phase 4 Inhalation Sedation;Intravenous Sedation
43 Efficacy of Adding Budesonide to Poractant Alfa to Prevent Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome. Recruiting NCT03521063 Phase 4 Budesonide;Poractant Alfa;Saline
44 Sedation With Sevoflurane Versus Propofol in Patients With Acute Respiratory Distress Syndrome Caused by COVID19 Infection Recruiting NCT04359862 Phase 4 Sevoflurane;Propofol
45 PRAETORIAN-COVID: A Double-blind, Placebo-controlled Randomized Clinical Trial With Valsartan for PRevention of Acute rEspiraTORy dIstress Syndrome in hospitAlized patieNts With SARS-COV-2 (COVID-19) Infection Disease Recruiting NCT04335786 Phase 4 Valsartan (Diovan);Placebo oral tablet
46 Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19 Recruiting NCT04325061 Phase 4 Dexamethasone
47 Efficacy of Rescue Surfactant Delivery Via Endotracheal Intubation (INSURE Technique) Versus Laryngeal Mask Airway (LMA) for Respiratory Distress Syndrome (RDS) in Preterm Neonates Recruiting NCT02164734 Phase 4 remifentanil
48 The Effect of Co-administered β-Carotene, Vitamin D3, Zinc and Antenatal Steroid Therapy on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone
49 Premedication for Less Invasive Surfactant Administration Recruiting NCT03735563 Phase 4 Ketamine;Fentanyl
50 Life-threatening Acute Respiratory Failure in Children: to Breathe or Not to Breathe Spontaneously, That's the Question Recruiting NCT02902055 Phase 4 Neuromuscular Blocking Agents;Isotonic saline

Search NIH Clinical Center for Newborn Respiratory Distress Syndrome

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Albumin Human, USP
colfosceril palmitate
Nitric Oxide
Poractant alfa

Cochrane evidence based reviews: hyaline membrane disease

Genetic Tests for Newborn Respiratory Distress Syndrome

Anatomical Context for Newborn Respiratory Distress Syndrome

MalaCards organs/tissues related to Newborn Respiratory Distress Syndrome:

Lung, Neutrophil, Testes, Fetal Lung, Heart, Kidney, Liver
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Newborn Respiratory Distress Syndrome:
# Tissue Anatomical CompartmentCell Relevance
1 Lung Pulmonary Capillary Plexus Affected by disease
2 Lung Alveoli Alveolar Epithelial Type 1 Cells Affected by disease, potential therapeutic candidate
3 Lung Alveoli Alveolar Epithelial Type 2 Cells Affected by disease, potential therapeutic candidate

Publications for Newborn Respiratory Distress Syndrome

Articles related to Newborn Respiratory Distress Syndrome:

(show top 50) (show all 1852)
# Title Authors PMID Year
Population and disease-based prevalence of the common mutations associated with surfactant deficiency. 61 54
18317237 2008
Neuroendoscopic lavage for the management of posthemorrhagic hydrocephalus in preterm infants: safety, effectivity, and lessons learned. 61
32413865 2020
Transcervical Foley Balloon Plus Vaginal Misoprostol versus Vaginal Misoprostol Alone for Cervical Ripening in Nulliparous Obese Women: A Multicenter, Randomized, Comparative-Effectiveness Trial. 61
32299108 2020
Inositol and pulmonary function. Could myo-inositol treatment downregulate inflammation and cytokine release syndrome in SARS-CoV-2? 61
32271462 2020
Extrauterine growth restriction in very preterm infant: etiology, diagnosis, and 2-year follow-up. 61
32193657 2020
50 Years Ago in TheJournalofPediatrics: Intermittent Positive Pressure Ventilation in Hyaline Membrane Disease. 61
32040408 2020
50 Years Ago in TheJournalofPediatrics: Commentary: The Use of Assisted Ventilation in the Therapy of Hyaline Membrane Disease. 61
32040409 2020
Bovine or Porcine: Does the Type of Surfactant Matter? 61
32112649 2020
Etiology, clinical profile and outcome of neonatal pneumothorax in tertiary care center in South India: 13 years experience. 61
32075452 2020
Risk Factors of Respiratory Diseases Among Neonates in Neonatal Intensive Care Unit of Qena University Hospital, Egypt. 61
32140431 2020
The influence of maternal ethnicity on neonatal respiratory outcome. 61
31123055 2020
Tension pneumocephalus, an uncommon complication of oxygen therapy in preterm newborns. Presentation of a case and literature review. 61
31784352 2019
Fetal, neonatal, and infant death in central China (Hubei): A 16-year retrospective study of forensic autopsy cases. 61
31169678 2019
Outcome of Respiratory Distress in Neonates with Bubble CPAP at Neonatal Intensive Care Unit of a Tertiary Hospital. 61
31477940 2019
Predictors of Neonatal mortality in Neonatal intensive care unit at referral Hospital in Southern Ethiopia: a retrospective cohort study. 61
30819143 2019
Growth restriction increases the risk of bronchopulmonary dysplasia, death, and sepsis in twins of 30 weeks or less of gestation. 61
31095217 2019
Co-initiation of continuous renal replacement therapy, peritoneal dialysis, and extracorporeal membrane oxygenation in neonatal life-threatening hyaline membrane disease: A case report. 61
30681590 2019
Case report of a laryngotracheal reconstruction with anterior and posterior costal cartilage graft and stent placement - Surgical technique. 61
31039513 2019
Survival and predictors among preterm neonates admitted at University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia. 61
30616641 2019
Hyaline membrane disease (HMD): an historical and Oslerian perspective. 61
30291319 2018
Proportion and factors of death among preterm neonates admitted in University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia. 61
30522518 2018
Perinatal outcomes in uncomplicated late preterm pregnancies with borderline oligohydramnios. 61
28782398 2018
Isolated neonatal bilateral vocal cord paralysis revealing a unilateral medullary defect: a case report. 61
30413155 2018
Outcomes of self-induced late pregnancy termination in women presenting to a tertiary hospital in the Eastern Cape Province, South Africa. 61
30645966 2018
Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. 61
30289565 2018
An autopsy based descriptive study of the spectrum of pulmonary lesions encountered in fetal deaths at a tertiary care center. 61
30303136 2018
A pre-term infant of 32 weeks gestation with congenital tuberculosis treated successfully with antituberculosis chemotherapy. 61
28805143 2018
Scenario of Neonatal Respiratory Distress in Tertiary Hospital. 61
29983424 2018
A study of spectrum of pulmonary pathology and expression of thyroid transcription factor-1 during neonatal period. 61
30004050 2018
Clinicoetiological Pattern and Outcome of Neonates Requiring Mechanical Ventilation: Study in a Tertiary Care Centre. 61
29910548 2018
Neonatal respiratory distress syndrome and underlying mechanisms in cloned cattle. 61
29388718 2018
Post-discharge body weight and neurodevelopmental outcomes among very low birth weight infants in Taiwan: A nationwide cohort study. 61
29444139 2018
Pulmonary atelectasis in newborns with clinically treatable diseases who are on mechanical ventilation: clinical and radiological aspects. 61
29559762 2018
Kidneys in 5-year-old preterm-born children: a longitudinal cohort monitoring of renal function. 61
28665930 2017
[Congenital cytomegalovirus infection manifesting as neonatal respiratory distress in an HIV-exposed uninfected newborn]. 61
28734808 2017
Postoperative complications following neonatal and infant surgery: Common events and predictive factors. 61
27671979 2017
Maternal and neonatal outcomes in twin and triplet gestations in Western Saudi Arabia. 61
28578447 2017
Prevalence of Lung Lesions at Autopsy: A Histopathological Study. 61
28658765 2017
Different ventilation modes combined with ambroxol in the treatment of respiratory distress syndrome in premature infants. 61
28352342 2017
[Perinatal Outcome in Relation to Chorionicity in Twin Pregnancy]. 61
28501032 2017
Probucol attenuates hyperoxia-induced lung injury in mice. 61
28384256 2017
Neonatal Ureaplasma urealyticum colonization increases pulmonary and cerebral morbidity despite treatment with macrolide antibiotics. 61
26518581 2016
Outcome of Twin Deliveries at a Tertiary Care Centre of Eastern Nepal. 61
27885296 2016
LARS2 Variants Associated with Hydrops, Lactic Acidosis, Sideroblastic Anemia, and Multisystem Failure. 61
26537577 2016
Formation of Hyaline Membranes in the Lungs of Albino Rat as a Result of Exposure to Bleomycin During the Neonatal Period. 61
26742747 2016
Neonatal respiratory distress in a reference neonatal unit in Cameroon: an analysis of prevalence, predictors, etiologies and outcomes. 61
27642489 2016
Maternal Risk Factors and Outcomes of Umbilical Cord Prolapse: A Population-Based Study. 61
26872752 2016
Institution Based Prospective Cross-Sectional Study on Patterns of Neonatal Morbidity at Gondar University Hospital Neonatal Unit, North-West Ethiopia. 61
26949319 2016
Newborn Respiratory Distress. 61
26760414 2015
Hospital admission due to respiratory viral infections in moderate preterm, late preterm and term infants during their first year of life. 61
25456533 2015

Variations for Newborn Respiratory Distress Syndrome

ClinVar genetic disease variations for Newborn Respiratory Distress Syndrome:

6 (show all 13) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 RALGAPA1 NM_014990.3(RALGAPA1):c.1126C>T (p.Arg376Ter)SNV Pathogenic 691794 14:36217916-36217916 14:35748710-35748710
2 RALGAPA1 NM_014990.3(RALGAPA1):c.4992del (p.Phe1664fs)deletion Pathogenic 691795 14:36096643-36096643 14:35627437-35627437
3 RALGAPA1 NM_014990.3(RALGAPA1):c.610G>T (p.Glu204Ter)SNV Pathogenic 691796 14:36226052-36226052 14:35756846-35756846
4 RALGAPA1 NM_014990.3(RALGAPA1):c.5732C>G (p.Ser1911Ter)SNV Pathogenic 691797 14:36041884-36041884 14:35572678-35572678
5 RALGAPA1 NM_014990.3(RALGAPA1):c.3227A>G (p.Asn1076Ser)SNV Pathogenic 691798 14:36143795-36143795 14:35674589-35674589
6 IGHMBP2 NM_002180.2(IGHMBP2):c.92G>A (p.Trp31Ter)SNV Pathogenic 242499 rs863224880 11:68673542-68673542 11:68906074-68906074
7 SYT2 NM_177402.5(SYT2):c.1084_1089del (p.Tyr362_Asp363del)deletion Likely pathogenic 373966 rs1057518805 1:202566056-202566061 1:202596928-202596933
8 SFTPC NM_003018.4(SFTPC):c.163C>T (p.Leu55Phe)SNV Likely pathogenic 598978 rs1563221666 8:22020207-22020207 8:22162694-22162694
9 ABCA3 NM_001089.3(ABCA3):c.614-2A>GSNV Likely pathogenic 598980 rs773223403 16:2369843-2369843 16:2319842-2319842
10 GJB2 NM_004004.6(GJB2):c.488T>C (p.Met163Thr)SNV Uncertain significance 449488 rs1273330603 13:20763233-20763233 13:20189094-20189094
11 ABCA3 NM_001089.3(ABCA3):c.3200G>A (p.Gly1067Glu)SNV Uncertain significance 598979 rs1567339065 16:2336773-2336773 16:2286772-2286772
12 DES NM_001927.4(DES):c.407T>A (p.Leu136His)SNV Uncertain significance 44261 rs397516695 2:220283591-220283591 2:219418869-219418869
13 PMP22 NM_000304.4(PMP22):c.422T>G (p.Val141Gly)SNV Uncertain significance 373965 rs1057518804 17:15134295-15134295 17:15230978-15230978

Expression for Newborn Respiratory Distress Syndrome

Search GEO for disease gene expression data for Newborn Respiratory Distress Syndrome.

Pathways for Newborn Respiratory Distress Syndrome

Pathways related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
Show member pathways
12.17 MIF IL6 IL1B CXCL8
Show member pathways
3 11.99 NR3C1 IL6 IL1B CXCL8
5 11.73 IL6 IL1B CXCL8
Show member pathways
7 11.65 NR3C1 IL6 CXCL8
8 11.55 SFTPA2 IL6 IL1B CXCL8
9 11.48 IL6 IL1B CXCL8
10 11.41 IL6 IL1B CXCL8
11 11.39 IL6 IL1B CXCL8
12 11.35 PLG IL6 ELANE
Show member pathways
11.35 NR3C1 MIF IL6 IL1B CXCL8
Show member pathways
15 11.26 NR3C1 IL6 IL1B
Show member pathways
Show member pathways
19 10.65 IL6 IL1B

GO Terms for Newborn Respiratory Distress Syndrome

Cellular components related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 TTN SFTPD SFTPC SFTPB SFTPA2 SCGB1A1
2 secretory granule GO:0030141 9.67 SCGB1A1 PLA2G2A IL1B ELANE
3 rough endoplasmic reticulum GO:0005791 9.63 SFTPD SFTPA2 SCGB1A1
4 multivesicular body GO:0005771 9.58 SFTPD SFTPB SFTPA2
5 lamellar body GO:0042599 9.5 SFTPC SFTPB SFTPA2
6 extracellular space GO:0005615 9.47 SFTPD SFTPC SFTPB SFTPA2 SCGB1A1 PLG
7 clathrin-coated endocytic vesicle GO:0045334 9.46 SFTPD SFTPC SFTPB SFTPA2
8 multivesicular body lumen GO:0097486 9.43 SFTPC SFTPB
9 alveolar lamellar body GO:0097208 9.43 SFTPC SFTPB ABCA3

Biological processes related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.61 MIF IL6 FGF7
2 response to glucocorticoid GO:0051384 9.54 SCGB1A1 IL6 ABCA3
3 antimicrobial humoral response GO:0019730 9.5 PLA2G2A EPPIN ELANE
4 negative regulation of T cell proliferation GO:0042130 9.43 SFTPD SCGB1A1 PLA2G2A
5 positive regulation of neuroinflammatory response GO:0150078 9.4 IL6 IL1B
6 respiratory gaseous exchange GO:0007585 9.26 SFTPD SFTPC SFTPB SFTPA2
7 cellular protein metabolic process GO:0044267 9.17 SFTPD SFTPC SFTPB SFTPA2 PLG IL6
8 negative regulation of chemokine biosynthetic process GO:0045079 9.16 IL6 ELANE

Molecular functions related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 MIF IL6 IL1B CXCL8

Sources for Newborn Respiratory Distress Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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