Aliases & Classifications for Newcastle Disease

MalaCards integrated aliases for Newcastle Disease:

Name: Newcastle Disease 12 54 44 15 17 70
Newcastle's Disease 12
Pseudo-Fowlpest 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2929
MeSH 44 D009521
NCIt 50 C34849
SNOMED-CT 67 258300000
UMLS 70 C0027983

Summaries for Newcastle Disease

Disease Ontology : 12 A viral infectious disease that results in infection in birds and humans, has material basis in Avian orthoavulavirus 1, which is transmitted by contact with feces and urine of an infected bird, or transmitted by fomites. The infection has symptom conjunctivitis, has symptom headache, and has symptom lacrimation in humans, and has symptom gasping, has symptom coughing, has symptom twisting of head and neck, has symptom circling, has symptom complete paralysis, has symptom watery diarrhea, and has symptom reduced egg production in birds.

MalaCards based summary : Newcastle Disease, also known as newcastle's disease, is related to avian influenza and stomatitis, and has symptoms including conjunctivitis, headache and coughing. An important gene associated with Newcastle Disease is IFNA1 (Interferon Alpha 1), and among its related pathways/superpathways are Innate Immune System and Viral mRNA Translation. The drugs Durvalumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include spleen, kidney and eye, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Newcastle Disease

Diseases related to Newcastle Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)
# Related Disease Score Top Affiliating Genes
1 avian influenza 30.9 TNFSF10 TNF NEU1 IVNS1ABP IRF7 IFNA1
2 stomatitis 30.9 TNF IFNB1 IFNA1 EIF2AK2 DDX58
3 mumps 30.8 TNF TLR3 IFNB1 IFNA1 EIF2AK2
4 parainfluenza virus type 3 30.5 NEU1 IFNB1 IFNA1 DDX58
5 poliomyelitis 30.3 TNF TLR3 IFNA1 DDX58
6 rubella 30.2 TNF TLR3 IFNB1 DDX58
7 encephalitis 30.2 TNF TLR3 IRF3 IFNB1 DDX58
8 viral encephalitis 30.1 TNF TLR3 IFNB1 IFNA1
9 rabies 30.0 TLR3 IRF7 IRF3 IFNA1 DDX58
10 west nile virus 30.0 IRF3 IFNA1 DDX58
11 severe acute respiratory syndrome 29.9 TNF IRF3 IFNB1 IFNA1 DDX58
12 vaccinia 29.9 TNF IRF7 IRF3 IFNB1 IFNA1 EIF2S1
13 crimean-congo hemorrhagic fever 29.9 TNF IFNB1 IFNA1 DDX58
14 hepatitis a 29.9 TNF TLR3 MAVS IFNA1
15 mouth disease 29.8 TLR3 IRF3 IFNA1 DDX58
16 influenza 29.7 TNF TLR3 NEU1 IVNS1ABP IRF7 IRF3
17 breast adenocarcinoma 29.7 TNF NFKBIA CASP9 CASP3
18 lymphocytic choriomeningitis 29.5 MAVS IRF3 DDX58
19 measles 29.5 TNF TLR3 IRF7 IRF3 IFNB1 IFNA1
20 swine influenza 29.5 TNF NEU1 IRF3 IFNB1 IFNA1 DDX58
21 immune deficiency disease 29.4 TNF NFKBIA IRF3 IFNB1 IFNA1 EIF2AK2
22 herpes simplex 29.4 TLR3 IRF7 IRF3 IFNB1 IFNA1 EIF2S1
23 west nile fever 29.3 IRF3 IFNA1
24 melanoma 29.3 TNFSF10 TNF IFNB1 IFNA1 EIF2AK2 DDX58
25 colon adenocarcinoma 29.3 TNFSF10 TNF CASP9 CASP3
26 hemorrhagic disease 29.2 TNF IRF3 IFNB1 IFNA1 DDX58
27 hepatitis 29.2 TNF MAVS IRF7 IRF3 IFNA1 EIF2AK2
28 leukemia, chronic myeloid 29.1 TNFSF10 NFKBIA IFNA1 CASP9 CASP3
29 japanese encephalitis 29.0 TNF TLR3 MAVS IVNS1ABP IRF3 IFNB1
30 burkitt lymphoma 28.8 TNF NFKBIA IRF3 IFNA1 CASP9 CASP3
31 viral infectious disease 27.8 TNFSF10 TNF TLR3 NEU1 NCR2 NCR1
32 bronchitis 10.8
33 plague 10.5
34 disease by infectious agent 10.5
35 laryngotracheitis 10.5
36 conjunctivitis 10.4
37 cholera 10.4
38 oral erosive lichen 10.4 IFNB1 IFNA1
39 respiratory syncytial virus infectious disease 10.4 NEU1 IFNB1
40 clear cell adenocarcinoma of the ovary 10.3 NEU1 IFI27
41 torticollis 10.3
42 glioblastoma 10.3
43 pfeiffer syndrome 10.3
44 null-cell leukemia 10.3 TNF IFNA1
45 listeria meningitis 10.3 TNF IFNB1
46 anogenital venereal wart 10.3 TLR3 IFNB1 IFNA1
47 adenocarcinoma 10.3
48 carcinoma showing thymus-like differentiation 10.3
49 glioma 10.3
50 glial tumor 10.3

Graphical network of the top 20 diseases related to Newcastle Disease:



Diseases related to Newcastle Disease

Symptoms & Phenotypes for Newcastle Disease

Symptoms:

12
  • conjunctivitis
  • headache
  • coughing
  • watery diarrhea
  • lacrimation in humans
  • gasping
  • twisting of head
  • circling
  • complete paralysis
  • reduced egg production in birds

UMLS symptoms related to Newcastle Disease:


discharge from eye

GenomeRNAi Phenotypes related to Newcastle Disease according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.28 EIF2AK2
2 Decreased viability GR00221-A-2 10.28 EIF2AK2
3 Decreased viability GR00221-A-3 10.28 EIF2AK2
4 Decreased viability GR00221-A-4 10.28 EIF2AK2
5 Decreased viability GR00249-S 10.28 CASP9 IRF7 TLR3
6 Decreased viability GR00301-A 10.28 EIF2AK2
7 Decreased viability GR00342-S-1 10.28 TLR3
8 Decreased viability GR00342-S-2 10.28 TLR3
9 Decreased viability GR00381-A-1 10.28 MAVS NCR1 NEU1
10 Decreased viability GR00386-A-1 10.28 EIF2S1 IFNB1 IVNS1ABP NEU1
11 Decreased viability GR00402-S-2 10.28 EIF2S1 TLR3 TNF TNFSF10
12 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CASP3 CASP9 EIF2S1 NFKBIA TNF TNFSF10
13 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CASP3 CASP9 EIF2AK2 EIF2S1 NFKBIA TNF
14 Increased the percentage of infected cells GR00402-S-1 8.85 TLR3
15 Upregulation of RLR pathway after Sendai virus (SeV) infection GR00302-A 8.32 CASP3

MGI Mouse Phenotypes related to Newcastle Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.2 CASP3 CASP9 DDX58 EIF2AK2 EIF2S1 IFNB1
2 homeostasis/metabolism MP:0005376 10.1 CASP3 DDX58 EIF2S1 IFNB1 IRF3 IRF7
3 immune system MP:0005387 10 CASP3 CASP9 DDX58 EIF2AK2 IFNB1 IRF3
4 mortality/aging MP:0010768 9.8 CASP3 CASP9 DDX58 EIF2AK2 EIF2S1 IRF7
5 respiratory system MP:0005388 9.23 CASP3 CASP9 IRF3 IVNS1ABP MAVS NEU1

Drugs & Therapeutics for Newcastle Disease

Drugs for Newcastle Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Durvalumab Approved, Investigational Phase 1 1428935-60-7
2 Antineoplastic Agents, Immunological Phase 1
3 Interleukin-12 Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II: Safety and Primary Efficacy of Clinical Application of Newcastle Disease Virus for the Treatment of Patients Resistant to All Conventional Modalities Withdrawn NCT00348842 Phase 2
2 An Open-label, Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of MEDI9253, a Recombinant Newcastle Disease Virus Encoding Interleukin-12, in Combination With Durvalumab in Participants With Select Advanced/Metastatic Solid Tumors Recruiting NCT04613492 Phase 1

Search NIH Clinical Center for Newcastle Disease

Cochrane evidence based reviews: newcastle disease

Genetic Tests for Newcastle Disease

Anatomical Context for Newcastle Disease

MalaCards organs/tissues related to Newcastle Disease:

40
Spleen, Kidney, Eye, T Cells, Bone Marrow, Colon, Monocytes

Publications for Newcastle Disease

Articles related to Newcastle Disease:

(show top 50) (show all 6742)
# Title Authors PMID Year
1
Antiviral response dictated by choreographed cascade of transcription factors. 61 54
20164420 2010
2
The rinderpest virus non-structural C protein blocks the induction of type 1 interferon. 54 61
19108859 2009
3
Capsid protein of eastern equine encephalitis virus inhibits host cell gene expression. 54 61
17267491 2007
4
Influenza virus evades innate and adaptive immunity via the NS1 protein. 61 54
16775317 2006
5
In vitro-generated viral double-stranded RNA in contrast to polyinosinic:polycytidylic acid induces interferon-alpha in human plasmacytoid dendritic cells. 54 61
16623926 2006
6
The regulatory roles of cell surface sialylation and N-glycans in human B cell lymphoma cell adhesion to galectin-1. 61 54
16327992 2006
7
N(pro) of classical swine fever virus is an antagonist of double-stranded RNA-mediated apoptosis and IFN-alpha/beta induction. 54 61
16043207 2005
8
Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons. 61 54
15651759 2004
9
Newcastle disease virus neuraminidase primes neutrophils for stimulation by galectin-3 and formyl-Met-Leu-Phe. 61 54
15242763 2004
10
Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III. 61 54
14729348 2004
11
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. 61 54
14679297 2004
12
Two ways to induce innate immune responses in human PBMCs: paracrine stimulation of IFN-alpha responses by viral protein or dsRNA. 61 54
12888903 2003
13
Differential expression of IFN-alpha subtypes in human PBMC: evaluation of novel real-time PCR assays. 54 61
12738374 2003
14
Dendritic cells pulsed with viral oncolysates potently stimulate autologous T cells from cancer patients. 54 61
12239606 2002
15
Production of interferons and change of the lymphocyte subpopulation phenotype in peripheral blood at cervical papillomavirus infection. 54 61
12630331 2002
16
[Time course of interferon status of patients with herpetic keratitis during treatment with actipol, a new inteferon inducer]. 61 54
11339038 2001
17
Virus-receptor interactions of human parainfluenza viruses types 1, 2 and 3. 61 54
10545258 1999
18
Increased cortisol levels in human umbilical cord blood inhibit interferon alpha production of neonates. 61 54
10416130 1999
19
Effect of granulocyte colony stimulating factor treatment on ex vivo cytokine production by blood cells of patients after chemotherapy or radiotherapy. 61 54
11729831 1999
20
IP-10 gene transcription by virus in astrocytes requires cooperation of ISRE with adjacent kappaB site but not IRF-1 or viral transcription. 61 54
9858321 1998
21
Abnormal surface expression of sialoglycans on B lymphocyte cell lines from patients with carbohydrate deficient glycoprotein syndrome I A (CDGS I A). 61 54
9719677 1998
22
Exogenous and endogenous IL-10 regulate IFN-alpha production by peripheral blood mononuclear cells in response to viral stimulation. 61 54
9637497 1998
23
[Cytokine release and changes in mononuclear cells in peripheral blood under the influence of general anesthesia]. 54 61
9645277 1998
24
Culture of human amniotic cells: a system to study interferon production. 54 61
9639327 1998
25
Correlation between interferon production and clinical disease activity in patients with multiple sclerosis. 61 54
9258768 1997
26
Constitutive and induced cytokine production by human placenta and amniotic membrane at term. 61 54
9250707 1997
27
Immunoregulatory effects of morphine on human lymphocytes. 61 54
9067644 1997
28
Loss ability to produce IFN-alpha in response to HIV-1 as monocytes differentiate into macrophages. Induction through a mechanism independent of double-stranded RNA. 54 61
8786308 1996
29
Interferon production by peripheral blood leukocytes of patients with acute myeloid leukemia. 61 54
8915515 1996
30
Tumor necrosis factor and interferon production by peripheral blood leukocytes of patients with alcoholic cirrhosis. 54 61
8915512 1996
31
Long-term assessment of interferon responses in the HIV+ and AIDS patients. 54 61
9017150 1996
32
Regulatory mechanisms of MuRantes and CRG-2 chemokine gene induction in central nervous system glial cells by virus. 54 61
8903850 1995
33
Production of interferons and lymphokines in leukocyte cultures of patients with schizophrenia. 61 54
7543276 1995
34
Influence of various factors on interferon-alpha production in cultures of human leukocytes. 61 54
7930756 1994
35
IFN and virus-inducible expression of an immediate early gene, crg-2/IP-10, and a delayed gene, I-A alpha in astrocytes and microglia. 61 54
8301141 1994
36
Human trophoblast interferons. 61 54
7506512 1993
37
Deficient interferon-alpha response of newborns in comparison to adults. 61 54
8391859 1993
38
Differential interferon production in human first and third trimester trophoblast cultures stimulated with viruses. 61 54
7685097 1993
39
Interferon-beta. A potential autocrine regulator of human vascular smooth muscle cell growth. 54 61
1602741 1992
40
Deficiency in interferon production of peripheral blood leukocytes from patients with non-Hodgkin lymphoma. 61 54
1379288 1992
41
Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes. 61 54
1371248 1992
42
GMP-140 binds to a glycoprotein receptor on human neutrophils: evidence for a lectin-like interaction. 54 61
1704009 1991
43
Regulation of cytokine and viral gene expression in monocytes infected with the human immunodeficiency virus. 54 61
1883515 1991
44
Effects of long-term zidovudine treatment on cell-mediated immune response and lymphokine production. 61 54
1704062 1991
45
A selective defect of interferon alpha production in human immunodeficiency virus-infected monocytes. 54 61
2264889 1990
46
Comparisons of peripheral blood and hepatic lymphocyte subpopulations and interferon production in chronic viral hepatitis. 61 54
1726220 1990
47
Long-term effects of 2'-deoxycoformycin treatment on cytokine production in patients with hairy cell leukemia. 61 54
1697012 1990
48
Hyporesponsiveness of human alveolar leukocytes to interferon-alpha and interferon-gamma inducers. 61 54
2125576 1990
49
gga-miR-1603 and gga-miR-1794 directly target viral L gene and function as a broad-spectrum antiviral factor against NDV replication. 61
33372825 2021
50
Development of a T7 RNA polymerase expressing cell line using lentivirus vectors for the recovery of recombinant Newcastle disease virus. 61
33592218 2021

Variations for Newcastle Disease

Expression for Newcastle Disease

Search GEO for disease gene expression data for Newcastle Disease.

Pathways for Newcastle Disease

Pathways related to Newcastle Disease according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 TNF TLR3 NFKBIA NEU1 NCR2 NCR1
2
Show member pathways
13.8 TNF TLR3 NFKBIA MAVS IRF3 IFNB1
3
Show member pathways
13.37 TNF IRF7 IRF3 IFNB1 IFNA1 IFI27
4
Show member pathways
13.01 TNF TLR3 IRF3 IFNB1 IFNA1 EIF2AK2
5
Show member pathways
13 TNFSF10 TNF TLR3 NFKBIA MAVS IRF7
6
Show member pathways
12.82 TNF TLR3 NFKBIA IRF7 IRF3 IFNB1
7
Show member pathways
12.74 TNFSF10 TNF NFKBIA IRF7 IRF3 EIF2S1
8
Show member pathways
12.73 TNFSF10 TNF NFKBIA CASP9 CASP3
9
Show member pathways
12.65 TNF NFKBIA EIF2S1 EIF2AK2 CASP3
10
Show member pathways
12.61 TNFSF10 TNF TLR3 NFKBIA CASP9 CASP3
11
Show member pathways
12.58 IRF7 IRF3 IFNB1 IFNA1 IFI27 EIF2AK2
12 12.57 TNF TLR3 NFKBIA MAVS IRF7 IRF3
13
Show member pathways
12.56 TNFSF10 TNF NCR2 NCR1 IFNB1 IFNA1
14
Show member pathways
12.54 TLR3 NFKBIA MAVS IRF7 IRF3 IFNB1
15
Show member pathways
12.47 TNF TLR3 NFKBIA IRF7 IRF3 IFNB1
16
Show member pathways
12.47 TNF NFKBIA MAVS IRF7 IRF3 IFNB1
17 12.47 TNF TLR3 NFKBIA MAVS IRF7 IRF3
18
Show member pathways
12.41 TLR3 NFKBIA IRF7 IRF3 CASP9
19 12.38 TNF NFKBIA IRF3 IFNB1
20 12.33 NFKBIA IRF7 IRF3 EIF2AK2 CASP3
21
Show member pathways
12.32 TNF TLR3 NFKBIA IRF7 IRF3 IFNB1
22
Show member pathways
12.29 TNF TLR3 NFKBIA IRF3
23
Show member pathways
12.29 TNF IRF7 IRF3 IFNB1 IFNA1 IFI27
24
Show member pathways
12.28 TNFSF10 TLR3 CASP9 CASP3
25 12.27 TNF IFNB1 IFNA1 CASP9 CASP3
26
Show member pathways
12.27 TNFSF10 TNF TLR3 IFNB1 IFNA1 EIF2AK2
27
Show member pathways
12.25 TNF NFKBIA CASP9 CASP3
28 12.24 TNFSF10 TNF CASP9 CASP3
29 12.21 TNF NFKBIA MAVS IRF7 IRF3 IFNB1
30 12.18 TNF TLR3 CASP9 CASP3
31
Show member pathways
12.18 TNFSF10 TNF TLR3 NFKBIA MAVS IRF7
32 12.15 IRF7 IRF3 IFNB1 IFNA1
33 12.08 TNF NFKBIA IRF3 IFNB1
34 11.98 TNF NFKBIA IFNB1 CASP3
35 11.9 TNF NFKBIA DDX58
36 11.84 NFKBIA CASP9 CASP3
37 11.84 NFKBIA CASP9 CASP3
38
Show member pathways
11.79 NFKBIA CASP9 CASP3
39 11.77 TNF NCR2 NCR1
40 11.74 TNF IRF3 CASP3
41 11.68 NFKBIA CASP9 CASP3
42 11.65 TNF NFKBIA CASP9 CASP3
43
Show member pathways
11.59 TNF NFKBIA EIF2S1 EIF2AK2
44 11.56 TNFSF10 IFNB1 IFNA1 CASP9 CASP3
45 11.47 TNF NFKBIA EIF2AK2
46 11.4 TNF CASP9 CASP3
47 11.18 TNF NFKBIA IFNB1
48
Show member pathways
11.02 MAVS IRF7 IRF3 EIF2AK2 DDX58

GO Terms for Newcastle Disease

Biological processes related to Newcastle Disease according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.16 TNF TLR3 NFKBIA MAVS IRF7 IRF3
2 apoptotic process GO:0006915 10.12 TNFSF10 NFKBIA IRF3 IFI27 CASP9 CASP3
3 immune system process GO:0002376 10.11 TLR3 MAVS IRF7 IRF3 IFI27 EIF2AK2
4 innate immune response GO:0045087 10.06 TLR3 NCR2 MAVS IRF7 IRF3 IFI27
5 positive regulation of apoptotic process GO:0043065 10.03 TNFSF10 TNF TLR3 CASP9 CASP3
6 viral process GO:0016032 10.03 NFKBIA MAVS IVNS1ABP IRF7 IRF3 IFI27
7 cytokine-mediated signaling pathway GO:0019221 10 TNF IFNB1 IFNA1 CASP3
8 response to lipopolysaccharide GO:0032496 9.94 NFKBIA IRF3 CASP9 CASP3
9 defense response GO:0006952 9.93 TNF TLR3 IFNB1 IFNA1
10 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 TNFSF10 TNF TLR3 MAVS IRF3
11 positive regulation of inflammatory response GO:0050729 9.87 TNF TLR3 NFKBIA
12 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.87 TNFSF10 TNF CASP9
13 positive regulation of tumor necrosis factor production GO:0032760 9.87 TLR3 MAVS DDX58
14 cellular response to organic cyclic compound GO:0071407 9.86 TNF CASP9 CASP3
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.86 TNF TLR3 EIF2AK2
16 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.85 TNF TLR3 NFKBIA
17 humoral immune response GO:0006959 9.85 TNF IFNB1 IFNA1
18 positive regulation of interleukin-6 production GO:0032755 9.85 TNF TLR3 MAVS DDX58
19 positive regulation of neuron apoptotic process GO:0043525 9.84 TNF CASP9 CASP3
20 positive regulation of type I interferon production GO:0032481 9.84 TLR3 IRF7 IRF3
21 apoptotic signaling pathway GO:0097190 9.84 TNF TLR3 IFI27 CASP3
22 positive regulation of cytokine production GO:0001819 9.83 TNF TLR3 EIF2AK2
23 extrinsic apoptotic signaling pathway GO:0097191 9.8 TNF TLR3 IFI27
24 positive regulation of interleukin-8 production GO:0032757 9.8 TNF TLR3 MAVS DDX58
25 type I interferon signaling pathway GO:0060337 9.8 IRF7 IRF3 IFNB1 IFNA1 IFI27
26 positive regulation of chemokine production GO:0032722 9.79 TNF TLR3 EIF2AK2
27 negative regulation of viral genome replication GO:0045071 9.78 TNF MAVS IFNB1 EIF2AK2
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 TNF NFKBIA IRF3
29 positive regulation of interferon-beta production GO:0032728 9.77 TLR3 MAVS IRF7 IRF3 DDX58
30 negative regulation of type I interferon production GO:0032480 9.76 MAVS IRF3 DDX58
31 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.75 TLR3 IRF7 IRF3
32 positive regulation of interferon-alpha production GO:0032727 9.72 TLR3 MAVS IRF7 IRF3 DDX58
33 regulation of type I interferon production GO:0032479 9.7 IRF7 IRF3
34 negative regulation of lipid storage GO:0010888 9.69 TNF NFKBIA
35 positive regulation of type I interferon-mediated signaling pathway GO:0060340 9.69 MAVS IRF7 IRF3
36 necroptotic signaling pathway GO:0097527 9.68 TNF TLR3
37 positive regulation of response to cytokine stimulus GO:0060760 9.67 MAVS DDX58
38 response to cobalt ion GO:0032025 9.65 CASP9 CASP3
39 detection of virus GO:0009597 9.65 TLR3 DDX58
40 positive regulation of myeloid dendritic cell cytokine production GO:0002735 9.65 MAVS DDX58
41 cellular response to exogenous dsRNA GO:0071360 9.65 TLR3 MAVS IRF3 IFNB1 DDX58
42 response to exogenous dsRNA GO:0043330 9.63 TLR3 NFKBIA IRF3 IFNB1 IFNA1 DDX58
43 leukocyte apoptotic process GO:0071887 9.61 CASP9 CASP3
44 MDA-5 signaling pathway GO:0039530 9.61 IRF7 IRF3
45 defense response to virus GO:0051607 9.61 TLR3 MAVS IRF7 IRF3 IFNB1 IFNA1
46 glial cell apoptotic process GO:0034349 9.6 CASP9 CASP3
47 response to virus GO:0009615 9.23 YJU2B TNF TLR3 IVNS1ABP IRF7 IFNB1

Molecular functions related to Newcastle Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 YJU2B TNFSF10 TNF TLR3 NFKBIA NEU1
2 cytokine activity GO:0005125 9.62 TNFSF10 TNF IFNB1 IFNA1
3 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.4 CASP9 CASP3
4 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.37 CASP9 CASP3
5 double-stranded RNA binding GO:0003725 9.33 TLR3 EIF2AK2 DDX58
6 identical protein binding GO:0042802 9.28 TNFSF10 TNF TLR3 NFKBIA IRF3 IFI27
7 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 9.26 CASP9 CASP3

Sources for Newcastle Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....