Aliases & Classifications for Newcastle Disease

MalaCards integrated aliases for Newcastle Disease:

Name: Newcastle Disease 12 56 45 15 17 74
Newcastle's Disease 12
Pseudo-Fowlpest 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2929
MeSH 45 D009521
NCIt 51 C34849
SNOMED-CT 69 89366008
UMLS 74 C0027983

Summaries for Newcastle Disease

Disease Ontology : 12 A viral infectious disease that results in infection in birds and humans, has material basis in Newcastle disease virus, which is transmitted by contact with feces and urine of an infected bird, or transmitted by fomites. The infection has symptom conjunctivitis, has symptom headache, and has symptom lacrimation in humans, and has symptom gasping, has symptom coughing, has symptom twisting of head and neck, has symptom circling, has symptom complete paralysis, has symptom watery diarrhea, and has symptom reduced egg production in birds.

MalaCards based summary : Newcastle Disease, also known as newcastle's disease, is related to influenza and parainfluenza virus type 3, and has symptoms including headache, conjunctivitis and coughing. An important gene associated with Newcastle Disease is IFNB1 (Interferon Beta 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include testes, t cells and brain, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Newcastle Disease

Diseases related to Newcastle Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 influenza 30.5 DDX58 IFNA1 IFNB1 IRF3 TLR3
2 parainfluenza virus type 3 30.1 IFNB1 NEU1
3 swine influenza 30.1 NEU1 TNF
4 encephalitis 30.0 DDX58 IRF3 TLR3
5 vaccinia 29.8 IFNA1 IFNB1 IRF3
6 measles 29.5 DDX58 IFNA1 IFNB1 TLR3
7 hepatitis 29.5 DDX58 IFNA1 IRF3 TNF
8 japanese encephalitis 29.4 DDX58 IFNB1 TLR3 TNF
9 fibrosarcoma 29.4 MAPK1 TIMP1 TNF
10 west nile virus 29.3 DDX58 IFNA1 IRF3 TLR3
11 herpes simplex 29.2 DDX58 IFNA1 IFNB1 IRF3 TLR3
12 noonan syndrome 3 28.9 DDX58 IFNA1 IFNB1 IRF3 TLR3
13 human immunodeficiency virus type 1 28.3 IFNA1 IRF3 MAPK1 TLR3 TNF
14 avian influenza 10.8
15 bronchitis 10.7
16 plague 10.4
17 respiratory syncytial virus infectious disease 10.3 IFNB1 NEU1
18 melanoma 10.3
19 stomatitis 10.3
20 laryngotracheitis 10.3
21 oral erosive lichen 10.3 IFNA1 IFNB1
22 murray valley encephalitis 10.2 IFNA1 IFNB1
23 trench fever 10.2 CCDC130 TNF
24 adenocarcinoma 10.2
25 marburg hemorrhagic fever 10.2 IFNB1 TNF
26 kashin-beck disease 10.2 BAX TNF
27 pfeiffer syndrome 10.2
28 colorectal cancer 10.2
29 hypercarotenemia and vitamin a deficiency, autosomal dominant 10.2
30 lung cancer 10.2
31 keratomalacia 10.2
32 mumps 10.2
33 glioma 10.2
34 farmer's lung 10.1 CD36 TNF
35 null-cell leukemia 10.1 IFNA1 TNF
36 conjunctivitis 10.1
37 autoimmune inner ear disease 10.1 TIMP1 TNF
38 mucocutaneous leishmaniasis 10.1 TLR3 TNF
39 herpangina 10.1 IFNA1 IFNB1
40 lung cancer susceptibility 3 10.1
41 cholera 10.1
42 glioblastoma 10.1
43 listeria meningitis 10.1 IFNB1 TNF
44 hepatocellular carcinoma 10.0
45 prostate cancer 10.0
46 prostate cancer, hereditary, 8 10.0
47 prostate cancer, hereditary, 6 10.0
48 deficiency anemia 10.0
49 lymphoma 10.0
50 rabies 10.0

Graphical network of the top 20 diseases related to Newcastle Disease:



Diseases related to Newcastle Disease

Symptoms & Phenotypes for Newcastle Disease

Symptoms:

12
  • headache
  • conjunctivitis
  • coughing
  • watery diarrhea
  • lacrimation in humans
  • gasping
  • twisting of head
  • circling
  • complete paralysis
  • reduced egg production in birds

UMLS symptoms related to Newcastle Disease:


discharge from eye

MGI Mouse Phenotypes related to Newcastle Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.14 BAX CD36 DDX58 IFNB1 IRF3 MAPK1
2 hematopoietic system MP:0005397 10.13 BAX CD36 DDX58 IFNB1 MAPK1 NEU1
3 immune system MP:0005387 10.11 BAX CD36 DDX58 IFNB1 IRF3 MAPK1
4 endocrine/exocrine gland MP:0005379 10 BAX CD36 MAPK1 TIMP1 TLR3 TNF
5 liver/biliary system MP:0005370 9.8 CD36 DDX58 MAPK1 NEU1 TNF TNFSF10
6 neoplasm MP:0002006 9.76 BAX DDX58 IFNB1 MAPK1 TIMP1 TLR3
7 muscle MP:0005369 9.73 BAX CD36 MAPK1 NEU1 TLR3 TNF
8 respiratory system MP:0005388 9.43 BAX MAPK1 NEU1 TIMP1 TLR3 TNF
9 skeleton MP:0005390 9.23 BAX CD36 IFNB1 MAPK1 NEU1 TIMP1

Drugs & Therapeutics for Newcastle Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Newcastle Disease Virus (NDV) for Cancer Patients Resistant to Conventional Anti-cancer Modalities Withdrawn NCT00348842 Phase 2

Search NIH Clinical Center for Newcastle Disease

Cochrane evidence based reviews: newcastle disease

Genetic Tests for Newcastle Disease

Anatomical Context for Newcastle Disease

MalaCards organs/tissues related to Newcastle Disease:

42
Testes, T Cells, Brain, Prostate, Kidney, Liver, Trachea

Publications for Newcastle Disease

Articles related to Newcastle Disease:

(show top 50) (show all 3057)
# Title Authors Year
1
Multiplex one-step real-time PCR assay for rapid simultaneous detection of velogenic and mesogenic Newcastle disease virus and H5-subtype avian influenza virus. ( 30790106 )
2019
2
Innovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines. ( 30917500 )
2019
3
Stability and virucidal efficacies using powder and liquid forms of fresh charcoal ash and slaked lime against Newcastle disease virus and Avian influenza virus. ( 30936648 )
2019
4
Combined H5ND inactivated vaccine protects chickens against challenge by different clades of highly pathogenic avian influenza viruses subtype H5 and virulent Newcastle disease virus. ( 30936661 )
2019
5
Prevalence of avian influenza, Newcastle disease, and infectious bronchitis viruses in broiler flocks infected with multifactorial respiratory diseases in Iran, 2015-2016. ( 30377950 )
2019
6
Establishment of xMAP for the simultaneous detection of antibodies to Newcastle disease virus and avian influenza virus. ( 30476286 )
2019
7
A novel recombinant attenuated Newcastle disease virus expressing H9 subtype hemagglutinin protected chickens from challenge by genotype VII virulent Newcastle disease virus and H9N2 avian influenza virus. ( 30593364 )
2019
8
Construction and Immunogenicity of Novel Chimeric Virus-Like Particles Bearing Antigens of Infectious Bronchitis Virus and Newcastle Disease Virus. ( 30871190 )
2019
9
Evaluation of Ultra-Microscopic Changes and Proliferation of Apoptotic Glioblastoma Multiforme Cells Induced by Velogenic Strain of Newcastle Disease Virus AF2240 ( 30909682 )
2019
10
Chicken infectious anemia virus helps fowl adenovirus break the protection of maternal antibody and cause inclusion body hepatitis-hydropericardium syndrome in layers after using co-contaminated Newcastle disease virus-attenuated vaccine. ( 30358862 )
2019
11
Fludarabine as an Adjuvant Improves Newcastle Disease Virus-Mediated Antitumor Immunity in Hepatocellular Carcinoma. ( 31011625 )
2019
12
Comparative analysis of early immune responses induced by two strains of Newcastle disease virus in chickens. ( 30070070 )
2019
13
Development of a recombinant Newcastle disease virus-vectored vaccine for infectious bronchitis virus variant strains circulating in Egypt. ( 30744668 )
2019
14
Impact of crossing Fayoumi and Leghorn chicken breeds on immune response against Newcastle disease virus vaccines. ( 30219997 )
2019
15
Molecular phylogenetics of Newcastle disease viruses isolated from vaccinated flocks during outbreaks in Southern India reveals circulation of a novel sub-genotype. ( 30281910 )
2019
16
The intracorporal interaction of fowl adenovirus type 4 and LaSota strain significantly aggravates the pathogenicity of one another after using contaminated Newcastle disease virus-attenuated vaccine. ( 30358868 )
2019
17
Molecular characterization, pathogenicity, and protection efficacy analysis of 2 wild-type lentogenic class I Newcastle disease viruses from chickens in China. ( 30376072 )
2019
18
Recombinant Newcastle disease virus (NDV) La Sota expressing the haemagglutinin-neuraminidase protein of genotype VII NDV shows improved protection efficacy against NDV challenge. ( 30465608 )
2019
19
Drivers of vaccination preferences to protect a low-value livestock resource: Willingness to pay for Newcastle disease vaccines by smallholder households. ( 30478006 )
2019
20
Comparative efficacy of commercial inactivated Newcastle disease virus vaccines against Newcastle disease virus genotype VII in broiler chickens. ( 30561723 )
2019
21
Synergetic pathogenicity of Newcastle disease vaccines LaSota strain and contaminated chicken infectious anemia virus. ( 30566627 )
2019
22
Explore the potential effect of natural herbals to resist Newcastle Disease Virus. ( 30566670 )
2019
23
High level expression of ISG12(1) promotes cell apoptosis via mitochondrial-dependent pathway and so as to hinder Newcastle disease virus replication. ( 30593361 )
2019
24
Non-replicating Newcastle Disease Virus as an adjuvant for DNA vaccine enhances antitumor efficacy through the induction of TRAIL and granzyme B expression. ( 30599161 )
2019
25
Attenuate Newcastle disease virus by codon modification of the glycoproteins and phosphoprotein genes. ( 30616204 )
2019
26
Newcastle disease virus-like particles containing the Brucella BCSP31 protein induce dendritic cell activation and protect mice against virulent Brucella challenge. ( 30642597 )
2019
27
Re-emergence of a genotype VIII virulent Newcastle disease virus isolated from Chinese game fowl after 13 years. ( 30658009 )
2019
28
Syncytia generated by hemagglutinin-neuraminidase and fusion proteins of virulent Newcastle disease virus induce complete autophagy by activating AMPK-mTORC1-ULK1 signaling>. ( 30658866 )
2019
29
MiR-375 Has Contrasting Effects on Newcastle Disease Virus Growth Depending on the Target Gene. ( 30662346 )
2019
30
Genetics and Genomic Regions Affecting Response to Newcastle Disease Virus Infection under Heat Stress in Layer Chickens. ( 30669351 )
2019
31
W protein expression by Newcastle Disease Virus. ( 30769123 )
2019
32
Velogenic newcastle disease virus tissue tropism and pathogenesis of infection in chickens by application of in situ PCR, immunoperoxase staining and HE staining. ( 30771470 )
2019
33
Expression and serological application of recombinant epitope-repeat protein carrying an immunodominant epitope of Newcastle disease virus nucleoprotein. ( 30775348 )
2019
34
Construction of a novel DNA vaccine candidate targeting F gene of genotype VII Newcastle disease virus and chicken IL-18 delivered by Salmonella. ( 30785663 )
2019
35
Nanobody-horseradish peroxidase fusion protein as an ultrasensitive probe to detect antibodies against Newcastle disease virus in the immunoassay. ( 30823927 )
2019
36
Molecular characterization of new emerging sub-genotype VIIh Newcastle disease viruses in China. ( 30835036 )
2019
37
Epidemiology, control, and prevention of Newcastle disease in endemic regions: Latin America. ( 30877525 )
2019
38
Nuclear localization of Newcastle disease virus matrix protein promotes virus replication by affecting viral RNA synthesis and transcription and inhibiting host cell transcription. ( 30894203 )
2019
39
Tissue metallothionein response in the Japanese quail associated with exposure to cyanobacterial biomass, lead and the Newcastle disease virus. ( 30927762 )
2019
40
Pathogenicity and transmission of virulent Newcastle disease virus from the 2018-2019 California outbreak and related viruses in young and adult chickens. ( 30928699 )
2019
41
Awareness and antibody detection of Newcastle disease virus in a neglected society in Nigeria. ( 30936663 )
2019
42
Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines. ( 30947706 )
2019
43
The enhanced immunological activity of Paulownia tomentosa flower polysaccharide on Newcastle disease vaccine in chicken. ( 30971500 )
2019
44
Evaluation of an immunochromatographic strip for detection of avian avulavirus 1 (Newcastle disease virus). ( 30973087 )
2019
45
Presence of Newcastle disease viruses of sub-genotypes Vc and VIn in backyard chickens and in apparently healthy wild birds from Mexico in 2017. ( 30976951 )
2019
46
Newcastle disease virus selectively infects dividing cells and promotes viral proliferation. ( 30999941 )
2019
47
Ongoing Outbreak of Newcastle Disease in Southern California, United States. ( 31001889 )
2019
48
Chicken viperin inhibits Newcastle disease virus infection in vitro: A possible interaction with the viral matrix protein. ( 31003187 )
2019
49
Experimental Infection of Turkeys with A Virulent Newcastle Disease Virus Isolated from Broiler Chickens. ( 31013006 )
2019
50
Correction to: Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines. ( 31018845 )
2019

Variations for Newcastle Disease

Expression for Newcastle Disease

Search GEO for disease gene expression data for Newcastle Disease.

Pathways for Newcastle Disease

Pathways related to Newcastle Disease according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 CD36 DDX58 IFNA1 IFNB1 IRF3 MAPK1
2
Show member pathways
13.57 BAX IFNA1 IFNB1 MAPK1 TIMP1 TNF
3
Show member pathways
13.4 BAX IFNA1 IFNB1 MAPK1 TIMP1 TNF
4
Show member pathways
13.19 CD36 IFNA1 IFNB1 IRF3 MAPK1 TIMP1
5
Show member pathways
13.08 CD36 DDX58 IFNA1 IFNB1 IRF3 MAPK1
6
Show member pathways
12.92 IFNA1 IFNB1 IRF3 MAPK1 TLR3 TNF
7
Show member pathways
12.69 BAX IRF3 MAPK1 TNF TNFSF10
8
Show member pathways
12.64 BAX IFNA1 IFNB1 IRF3 MAPK1 TLR3
9
Show member pathways
12.55 DDX58 IFNA1 IFNB1 IRF3 TLR3 TNF
10
Show member pathways
12.55 BAX DDX58 IFNA1 IFNB1 IRF3 MAPK1
11
Show member pathways
12.5 IRF3 MAPK1 TLR3 TNF TNFSF10
12
Show member pathways
12.48 BAX MAPK1 TIMP1 TNF
13
Show member pathways
12.42 DDX58 IFNA1 IFNB1 IRF3
14 12.39 DDX58 IFNA1 IRF3 TLR3 TNF
15
Show member pathways
12.33 IFNA1 IFNB1 MAPK1 TNF TNFSF10
16
Show member pathways
12.2 IRF3 MAPK1 TLR3 TNF
17
Show member pathways
12.14 BAX MAPK1 TNFSF10
18
Show member pathways
12.1 IFNA1 IFNB1 IRF3 TIMP1 TNF
19 12.06 IFNA1 IFNB1 IRF3
20 12.04 BAX MAPK1 TLR3 TNF
21
Show member pathways
11.97 BAX MAPK1 TIMP1 TNFSF10
22 11.97 BAX IFNA1 IFNB1 MAPK1 TNF
23 11.95 IFNB1 MAPK1 TNF
24
Show member pathways
11.93 BAX MAPK1 TNF
25 11.9 BAX MAPK1 TNF
26 11.88 CD36 TIMP1 TNF
27 11.86 IFNB1 MAPK1 TNF
28 11.8 BAX MAPK1 TNF
29 11.79 IFNA1 IFNB1 MAPK1
30
Show member pathways
11.71 CD36 IFNB1 IRF3 MAPK1 TLR3 TNF
31 11.67 IRF3 MAPK1 TNF
32 11.46 BAX TNF TNFSF10
33 11.42 CD36 MAPK1 TNF
34 11.37 BAX MAPK1 TNF
35 11.35 IFNA1 IFNB1 TNFSF10
36
Show member pathways
11.34 BAX IFNA1 IFNB1 TLR3 TNF TNFSF10
37
Show member pathways
11.05 DDX58 IRF3
38 11.02 MAPK1 TNF
39
Show member pathways
11.02 BAX TNFSF10
40 10.99 IFNB1 MAPK1 TNF
41 10.95 BAX TNF
42 10.9 BAX MAPK1 TIMP1 TNF TNFSF10
43 10.86 CD36 TNF

GO Terms for Newcastle Disease

Cellular components related to Newcastle Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CD36 IFNA1 IFNB1 TIMP1 TLR3 TNF

Biological processes related to Newcastle Disease according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.97 BAX DDX58 IRF3 MAPK1
2 regulation of signaling receptor activity GO:0010469 9.95 IFNA1 IFNB1 TIMP1 TNF TNFSF10
3 positive regulation of apoptotic process GO:0043065 9.94 BAX TLR3 TNF TNFSF10
4 positive regulation of gene expression GO:0010628 9.93 CD36 DDX58 MAPK1 TLR3 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 CD36 TLR3 TNF
6 defense response GO:0006952 9.81 IFNA1 IFNB1 TLR3 TNF
7 male gonad development GO:0008584 9.8 BAX TLR3 TNFSF10
8 cytokine-mediated signaling pathway GO:0019221 9.8 CD36 IFNA1 IFNB1 TIMP1 TNF
9 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.79 BAX TNF TNFSF10
10 type I interferon signaling pathway GO:0060337 9.77 IFNA1 IFNB1 IRF3
11 apoptotic signaling pathway GO:0097190 9.76 BAX TLR3 TNF
12 humoral immune response GO:0006959 9.74 IFNA1 IFNB1 TNF
13 defense response to virus GO:0051607 9.72 DDX58 IFNA1 IFNB1 IRF3 TLR3
14 extrinsic apoptotic signaling pathway GO:0097191 9.7 BAX TLR3 TNF
15 cellular response to lipopolysaccharide GO:0071222 9.68 CD36 TNF
16 positive regulation of interleukin-12 production GO:0032735 9.68 CD36 TLR3
17 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.67 IRF3 TLR3
18 T cell activation involved in immune response GO:0002286 9.67 IFNA1 IFNB1
19 cellular response to interferon-beta GO:0035458 9.66 IFNB1 TLR3
20 positive regulation of chemokine production GO:0032722 9.65 TLR3 TNF
21 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.65 IFNA1 IFNB1
22 microglial cell activation GO:0001774 9.65 TLR3 TNF
23 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.65 CD36 IRF3 TLR3 TNF TNFSF10
24 natural killer cell activation involved in immune response GO:0002323 9.64 IFNA1 IFNB1
25 negative regulation of growth of symbiont in host GO:0044130 9.63 CD36 TNF
26 positive regulation of interleukin-8 production GO:0032757 9.63 DDX58 TLR3 TNF
27 positive regulation of interferon-alpha production GO:0032727 9.62 DDX58 IRF3
28 regulation of protein heterodimerization activity GO:0043497 9.61 BAX CD36
29 response to salt stress GO:0009651 9.61 BAX TNF
30 positive regulation of interferon-beta production GO:0032728 9.61 DDX58 IRF3 TLR3
31 positive regulation of chemokine biosynthetic process GO:0045080 9.6 TLR3 TNF
32 necroptotic signaling pathway GO:0097527 9.58 TLR3 TNF
33 detection of virus GO:0009597 9.56 DDX58 TLR3
34 cellular response to exogenous dsRNA GO:0071360 9.54 DDX58 IFNB1 TLR3
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.49 MAPK1 TNF
36 positive regulation of blood microparticle formation GO:2000334 9.48 CD36 TNF
37 positive regulation of interleukin-6 production GO:0032755 9.46 CD36 DDX58 TLR3 TNF
38 response to virus GO:0009615 9.35 CCDC130 DDX58 IFNB1 TLR3 TNF
39 response to exogenous dsRNA GO:0043330 9.02 DDX58 IFNA1 IFNB1 MAPK1 TLR3

Molecular functions related to Newcastle Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 BAX DDX58 IRF3 MAPK1 TLR3 TNF
2 type I interferon receptor binding GO:0005132 9.16 IFNA1 IFNB1
3 cytokine activity GO:0005125 9.02 IFNA1 IFNB1 TIMP1 TNF TNFSF10

Sources for Newcastle Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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