Aliases & Classifications for Newcastle Disease

MalaCards integrated aliases for Newcastle Disease:

Name: Newcastle Disease 12 55 44 15 73
Newcastle's Disease 12
Pseudo-Fowlpest 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2929
MeSH 44 D009521
NCIt 50 C34849
UMLS 73 C0027983

Summaries for Newcastle Disease

Disease Ontology : 12 A viral infectious disease that results in infection in birds and humans, has material basis in Newcastle disease virus, which is transmitted by contact with feces and urine of an infected bird, or transmitted by fomites. The infection has symptom conjunctivitis, has symptom headache, and has symptom lacrimation in humans, and has symptom gasping, has symptom coughing, has symptom twisting of head and neck, has symptom circling, has symptom complete paralysis, has symptom watery diarrhea, and has symptom reduced egg production in birds.

MalaCards based summary : Newcastle Disease, also known as newcastle's disease, is related to parainfluenza virus type 3 and measles, and has symptoms including conjunctivitis, headache and lacrimation in humans. An important gene associated with Newcastle Disease is IFNB1 (Interferon Beta 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include lung, eye and t cells, and related phenotypes are hematopoietic system and cellular

Wikipedia : 76 Newcastle disease is a contagious viral bird disease affecting many domestic and wild avian species; it... more...

Related Diseases for Newcastle Disease

Diseases related to Newcastle Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 parainfluenza virus type 3 30.4 IFNB1 NEU1
2 measles 29.7 DDX58 IFNA1 IFNB1
3 influenza 29.7 DDX58 IFNA1 IFNB1 IRF3 IRF7
4 hepatitis 28.7 DDX58 IFNA1 IRF3 IRF7
5 respiratory syncytial virus infectious disease 10.6 IFNB1 NEU1
6 oral erosive lichen 10.6 IFNA1 IFNB1
7 avian influenza 10.5
8 pseudo-torch syndrome 1 10.5 IFNA1 IFNB1
9 venezuelan equine encephalitis 10.4 IFNB1 IRF7
10 septicemic plague 10.3 IFNB1 IRF3
11 japanese encephalitis 10.2 DDX58 IFNB1
12 bronchitis 10.2
13 laryngotracheitis 10.2
14 eczema herpeticum 10.1 IRF3 IRF7
15 pancreatitis 10.1
16 la crosse encephalitis 10.0 DDX58 IFNB1 IRF3
17 spinal cord astrocytoma 10.0 BSG IFNB1
18 mucositis 10.0
19 type i 10.0
20 cerebral primitive neuroectodermal tumor 10.0 BSG IFNB1
21 adenocarcinoma 10.0
22 severe acute respiratory syndrome 9.9 IFNA1 IFNB1 IRF3
23 prostate cancer 9.9
24 lung cancer susceptibility 3 9.9
25 rabies 9.9
26 prostatitis 9.9
27 melanoma 9.9
28 encephalitis 9.9
29 stomatitis 9.9
30 glioma 9.9
31 west nile virus 9.9 DDX58 IFNA1 IRF3
32 prostatic hypertrophy 9.8 CD36 KLK3
33 lung cancer 9.8
34 aging 9.8
35 gastric cancer 9.8
36 peritonitis 9.8
37 carbuncle 9.7 BAX CASP9
38 hepatocellular carcinoma 9.7
39 neuraminidase deficiency 9.7
40 neuroblastoma 9.7
41 pancreatic cancer 9.7
42 arthritis 9.7
43 leukemia 9.7
44 malignant glioma 9.7
45 pancreas adenocarcinoma 9.7
46 phaeochromocytoma 9.7
47 oral squamous cell carcinoma 9.7
48 mumps 9.7
49 tonsillitis 9.7
50 eastern equine encephalitis 9.7

Graphical network of the top 20 diseases related to Newcastle Disease:



Diseases related to Newcastle Disease

Symptoms & Phenotypes for Newcastle Disease

Symptoms:

12
  • conjunctivitis
  • headache
  • lacrimation in humans
  • gasping
  • coughing
  • twisting of head
  • circling
  • complete paralysis
  • watery diarrhea
  • reduced egg production in birds

UMLS symptoms related to Newcastle Disease:


discharge from eye

MGI Mouse Phenotypes related to Newcastle Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 VHL DDX58 IFNB1 BAX IRF7 BSG
2 cellular MP:0005384 10.01 VHL DDX58 IRF3 BAX CASP9 MAPK1
3 immune system MP:0005387 10 IFNB1 IRF3 BAX IRF7 BSG MAPK1
4 homeostasis/metabolism MP:0005376 9.97 VHL DDX58 IFNB1 IRF3 BAX IRF7
5 liver/biliary system MP:0005370 9.63 VHL DDX58 BSG MAPK1 CD36 NEU1
6 neoplasm MP:0002006 9.35 VHL DDX58 IFNB1 BAX MAPK1
7 taste/olfaction MP:0005394 8.8 MAPK1 CASP9 CD36

Drugs & Therapeutics for Newcastle Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Newcastle Disease Virus (NDV) for Cancer Patients Resistant to Conventional Anti-cancer Modalities Withdrawn NCT00348842 Phase 2

Search NIH Clinical Center for Newcastle Disease

Cochrane evidence based reviews: newcastle disease

Genetic Tests for Newcastle Disease

Anatomical Context for Newcastle Disease

MalaCards organs/tissues related to Newcastle Disease:

41
Lung, Eye, T Cells, Prostate, Monocytes, Testes, Brain

Publications for Newcastle Disease

Articles related to Newcastle Disease:

(show top 50) (show all 723)
# Title Authors Year
1
Molecular characterization of hemagglutinin-neuraminidase fragment gene of Newcastle disease virus isolated from periodically-vaccinated farms. ( 29915505 )
2018
2
Newcastle disease virus co-expressing interleukin 7 and interleukin 15 modified tumor cells as a vaccine for cancer immunotherapy. ( 29224228 )
2018
3
Evaluation of spray and oral delivery of Newcastle disease I2 vaccine in chicken reared by smallholder farmers in central Ethiopia. ( 29439696 )
2018
4
Recombinant Newcastle disease viruses with targets for PCR diagnostics for rinderpest and peste des petits ruminants. ( 29906491 )
2018
5
Acute phase proteins and stress markers in the immediate response to a combined vaccination against Newcastle disease and infectious bronchitis viruses in specific pathogen free (SPF) layer chicks. ( 29182756 )
2018
6
Newcastle disease virus induces G<sub>0</sub>/G<sub>1</sub> cell cycle arrest in asynchronously growing cells. ( 29793075 )
2018
7
Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines. ( 29352240 )
2018
8
Erratum: Author Correction: Newcastle disease virus-based H5 influenza vaccine protects chickens from lethal challenge with a highly pathogenic H5N2 avian influenza virus. ( 29799537 )
2018
9
Emergence of a Virulent Genotype VIIi of Newcastle Disease Virus in Iran. ( 29954188 )
2018
10
Pathological and molecular investigation of velogenic viscerotropic Newcastle disease outbreak in a vaccinated chicken flocks. ( 29911151 )
2018
11
Antitumor effect of the Newcastle disease viral hemagglutinin-neuraminidase gene is expressed through an oncolytic adenovirus effect in osteosarcoma cells. ( 29438228 )
2018
12
Can genotype mismatch really affect the level of protection conferred by Newcastle disease vaccines against heterologous virulent strains? ( 29843999 )
2018
13
Effects of Newcastle Disease Virus Infection on Chicken Intestinal Intraepithelial Natural Killer Cells. ( 29973933 )
2018
14
Whole-genome sequencing of genotype VI Newcastle disease viruses from formalin-fixed paraffin-embedded tissues from wild pigeons reveals continuous evolution and previously unrecognized genetic diversity in the U.S. ( 29329546 )
2018
15
Immune responses of mature chicken bone-marrow-derived dendritic cells infected with Newcastle disease virus strains with differing pathogenicity. ( 29397456 )
2018
16
Risk factors for Newcastle disease in broiler farms in Israel. ( 29290305 )
2018
17
Diagnosis of virulent Newcastle disease in southern California, May 2018. ( 29952744 )
2018
18
Modified Newcastle Disease virus as an improved vaccine vector against Simian Immunodeficiency virus. ( 29895833 )
2018
19
Regulation of Constitutive Interferon-Stimulated Genes (Isgs) in Tumor Cells Contributes to Enhanced Antitumor Response of Newcastle Disease Virus-Infected Tumor Vaccines. ( 29882780 )
2018
20
Newcastle Disease Virus-Based Vectored Vaccine against Poliomyelitis. ( 29925653 )
2018
21
Evaluation of the effect of live LaSota Newcastle disease virus vaccine as primary immunization on immune development in broilers. ( 29211892 )
2018
22
Supplementation of Vitamin E Protects Chickens from Newcastle Disease Virus-Mediated Exacerbation of Intestinal Oxidative Stress and Tissue Damage. ( 29949793 )
2018
23
Newcastle Disease Virus Infection Interferes With the Formation of Intestinal Microflora in Newly Hatched Specific-Pathogen-Free Chicks. ( 29867811 )
2018
24
Potent Inhibitors against Newcastle Disease Virus Hemagglutinin-Neuraminidase. ( 29231283 )
2018
25
Effect of adjuvants on in ovo vaccination against Newcastle disease on hatchability, performance and antibody titres in commercial pullets. ( 29740890 )
2018
26
Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine. ( 29399179 )
2018
27
Dendritic cell targeted HIV-1 gag protein vaccine provides help to a recombinant Newcastle disease virus vectored vaccine including mobilization of protective CD8<sup>+</sup>T cells. ( 29205929 )
2018
28
Saponin-adjuvanted vaccine protects chickens against velogenic Newcastle disease virus. ( 29968048 )
2018
29
Newcastle disease virus: is an updated attenuated vaccine needed? ( 29897786 )
2018
30
Validation of immunomodulatory effects of lipopolysaccharide through expression profiling of Th1 and Th2 biased genes in Newcastle disease virus vaccinated indigenous chicken. ( 29805207 )
2018
31
Effect of fusion protein cleavage site sequence on generation of a genotype VII Newcastle disease virus vaccine. ( 29758054 )
2018
32
Efficacy of vaccination with La Sota strain vaccine to control Newcastle disease in village chickens in Nepal. ( 27987111 )
2017
33
The role of vaccination in risk mitigation and control of Newcastle disease in poultry. ( 28951084 )
2017
34
Comprehensive analysis of amino acid sequence diversity at the F protein cleavage site of Newcastle disease virus in fusogenic activity. ( 28863165 )
2017
35
Detection of specific antigens of Newcastle disease virus using an absorbed Western blotting method. ( 28775747 )
2017
36
Tracing the origins of genotype VIIh Newcastle disease in southern Africa. ( 29178267 )
2017
37
Complete Genome Sequence of a Newcastle Disease Genotype XIII Virus Isolated from Indigenous Chickens in Zambia. ( 28839026 )
2017
38
Comparison of the efficiency of different newcastle disease virus reverse genetics systems. ( 28867302 )
2017
39
Analysis of molecular evolution of nucleocapsid protein in Newcastle disease virus. ( 29228598 )
2017
40
Adenoviral-expressed recombinant granulocyte monocyte colony-stimulating factor (GM-CSF) enhances protective immunity induced by inactivated Newcastle Disease Virus (NDV) vaccine. ( 28698014 )
2017
41
Recombinant Newcastle disease virus expressing the infectious bronchitis virus S1 gene protects chickens against Newcastle disease virus and infectious bronchitis virus challenge. ( 28342665 )
2017
42
Immune Effect of Newcastle Disease Virus DNA Vaccine with C3d as a Molecular Adjuvant. ( 29061032 )
2017
43
Newcastle disease virus mediates pancreatic tumor rejection via NK cell activation and prevents cancer relapse by prompting adaptive immunity. ( 28857157 )
2017
44
Evaluating the efficacy of LaSota vaccination induced protection in chickens upon challenge with a genotype IV strain of Newcastle disease virus. ( 29291221 )
2017
45
Newcastle disease virus from domestic mink, China, 2014. ( 28061999 )
2017
46
Induction of antitumor response to fibrosarcoma by Newcastle disease virus-infected tumor vaccine. ( 28864944 )
2017
47
Two mutations in the HR2 region of Newcastle disease virus fusion protein with a cleavage motif &amp;quot;RRQRRL&amp;quot; are critical for fusogenic activity. ( 28946881 )
2017
48
Protective efficacy of combined trivalent inactivated ISA 71 oil adjuvant vaccine against avian influenza virus subtypes (H9N2 and H5N1) and Newcastle disease virus. ( 29184367 )
2017
49
Genetically engineered oncolytic Newcastle disease virus mediates cytolysis of prostate cancer stem like cells. ( 28935568 )
2017
50
Spillover of Newcastle disease viruses from poultry to wild birds in Guangdong province, southern China. ( 28935610 )
2017

Variations for Newcastle Disease

Expression for Newcastle Disease

Search GEO for disease gene expression data for Newcastle Disease.

Pathways for Newcastle Disease

Pathways related to Newcastle Disease according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 CASP9 CD36 DDX58 IFNA1 IFNB1 IRF3
2
Show member pathways
13.16 CD36 DDX58 IFNA1 IFNB1 IRF3 IRF7
3
Show member pathways
13.1 BSG CD36 IFNA1 IFNB1 IRF3 IRF7
4
Show member pathways
12.87 IFNA1 IFNB1 IRF3 IRF7 MAPK1
5
Show member pathways
12.76 BAX CASP9 IFNA1 IFNB1 IRF3 MAPK1
6
Show member pathways
12.67 BAX CASP9 IRF3 IRF7 MAPK1
7
Show member pathways
12.61 DDX58 IFNA1 IFNB1 IRF3 IRF7
8 12.57 BAX CASP9 IFNA1 KLK3 MAPK1 VHL
9
Show member pathways
12.5 IFNA1 IFNB1 IRF3 IRF7
10 12.43 DDX58 IFNA1 IRF3 IRF7
11
Show member pathways
12.39 CASP9 DDX58 IFNA1 IFNB1 IRF3 IRF7
12
Show member pathways
12.32 DDX58 IFNA1 IFNB1 IRF3 IRF7
13
Show member pathways
12.29 CASP9 IRF3 IRF7 MAPK1
14 12.16 BAX IRF3 IRF7 MAPK1
15
Show member pathways
12.13 BAX CASP9 MAPK1
16
Show member pathways
12.08 BAX IFNA1 IFNB1
17 12.06 BAX CASP9 MAPK1
18 12.02 BAX CASP9 MAPK1
19
Show member pathways
12.01 BAX CASP9 MAPK1
20
Show member pathways
12 CD36 IFNB1 IRF3 IRF7 MAPK1
21 11.99 IFNA1 IFNB1 IRF3 IRF7
22
Show member pathways
11.91 BAX CASP9 MAPK1
23 11.91 BAX CASP9 IFNA1 IFNB1 MAPK1
24
Show member pathways
11.9 BAX CASP9 MAPK1
25 11.83 IFNB1 IRF7 MAPK1
26 11.77 IFNA1 IFNB1 MAPK1
27
Show member pathways
11.74 BAX CASP9 DDX58 IFNA1 IFNB1 IRF3
28
Show member pathways
11.69 BAX CASP9 MAPK1
29
Show member pathways
11.69 BAX CASP9 MAPK1
30 11.62 BAX CASP9 MAPK1
31 11.55 DDX58 IFNA1 IFNB1 IRF3 IRF7 MAPK1
32 11.32 CASP9 IFNA1 IFNB1
33
Show member pathways
11.31 BAX CASP9 MAPK1
34 11.2 BAX MAPK1
35 11.12 BAX MAPK1
36 11.04 IFNB1 MAPK1
37 11.02 BAX CASP9
38
Show member pathways
10.94 DDX58 IRF3 IRF7
39 10.87 BSG MAPK1

GO Terms for Newcastle Disease

Biological processes related to Newcastle Disease according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.93 DDX58 IFNA1 IRF3 IRF7
2 cellular response to DNA damage stimulus GO:0006974 9.85 BAX CASP9 IRF3 IRF7 MAPK1
3 viral process GO:0016032 9.83 BAX DDX58 IRF3 IRF7 MAPK1
4 cell surface receptor signaling pathway GO:0007166 9.81 BSG CD36 IFNB1 MAPK1
5 blood coagulation GO:0007596 9.8 CD36 IFNA1 IFNB1
6 response to lipopolysaccharide GO:0032496 9.79 CASP9 IRF3 MAPK1
7 response to virus GO:0009615 9.71 DDX58 IFNB1 IRF7
8 B cell proliferation GO:0042100 9.63 IFNA1 IFNB1
9 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.61 BAX CASP9
10 lipopolysaccharide-mediated signaling pathway GO:0031663 9.61 IRF3 MAPK1
11 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.6 IRF3 IRF7
12 regulation of type I interferon-mediated signaling pathway GO:0060338 9.59 IFNA1 IFNB1
13 T cell activation involved in immune response GO:0002286 9.58 IFNA1 IFNB1
14 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.58 IFNA1 IFNB1
15 natural killer cell activation involved in immune response GO:0002323 9.57 IFNA1 IFNB1
16 regulation of type I interferon production GO:0032479 9.56 IRF3 IRF7
17 cellular response to exogenous dsRNA GO:0071360 9.55 DDX58 IFNB1
18 positive regulation of type I interferon-mediated signaling pathway GO:0060340 9.52 IRF3 IRF7
19 positive regulation of interferon-beta production GO:0032728 9.5 DDX58 IRF3 IRF7
20 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.49 BAX CASP9
21 regulation of protein heterodimerization activity GO:0043497 9.48 BAX CD36
22 type I interferon signaling pathway GO:0060337 9.46 IFNA1 IFNB1 IRF3 IRF7
23 positive regulation of interferon-alpha production GO:0032727 9.43 DDX58 IRF3 IRF7
24 type I interferon biosynthetic process GO:0045351 9.4 IRF3 IRF7
25 MDA-5 signaling pathway GO:0039530 9.37 IRF3 IRF7
26 defense response to virus GO:0051607 9.35 DDX58 IFNA1 IFNB1 IRF3 IRF7
27 response to exogenous dsRNA GO:0043330 9.02 DDX58 IFNA1 IFNB1 IRF3 MAPK1

Molecular functions related to Newcastle Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 8.96 IFNA1 IFNB1
2 type I interferon receptor binding GO:0005132 8.62 IFNA1 IFNB1

Sources for Newcastle Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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