Aliases & Classifications for Newcastle Disease

MalaCards integrated aliases for Newcastle Disease:

Name: Newcastle Disease 12 55 44 15 73
Newcastle's Disease 12
Pseudo-Fowlpest 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2929
MeSH 44 D009521
NCIt 50 C34849
SNOMED-CT 68 89366008
UMLS 73 C0027983

Summaries for Newcastle Disease

Disease Ontology : 12 A viral infectious disease that results in infection in birds and humans, has material basis in Newcastle disease virus, which is transmitted by contact with feces and urine of an infected bird, or transmitted by fomites. The infection has symptom conjunctivitis, has symptom headache, and has symptom lacrimation in humans, and has symptom gasping, has symptom coughing, has symptom twisting of head and neck, has symptom circling, has symptom complete paralysis, has symptom watery diarrhea, and has symptom reduced egg production in birds.

MalaCards based summary : Newcastle Disease, also known as newcastle's disease, is related to influenza and viral infectious disease, and has symptoms including conjunctivitis, headache and coughing. An important gene associated with Newcastle Disease is IFNB1 (Interferon Beta 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include lung, testes and eye, and related phenotypes are Upregulation of RLR pathway after Sendai virus (SeV) infection and immune system

Wikipedia : 76 Newcastle disease is a contagious viral bird disease affecting many domestic and wild avian species; it... more...

Related Diseases for Newcastle Disease

Diseases related to Newcastle Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 influenza 30.9 DDX58 IFNA1 IFNB1 IRF3
2 viral infectious disease 30.2 DDX58 IFNA1 IFNB1 IRF3 TNF
3 swine influenza 30.1 NEU1 TNF
4 parainfluenza virus type 3 30.0 IFNB1 NEU1
5 measles 29.8 DDX58 IFNA1 IFNB1
6 hepatitis 29.6 DDX58 IFNA1 IRF3 TNF
7 west nile virus 29.5 DDX58 IFNA1 IRF3
8 vaccinia 29.4 IFNA1 IFNB1 IRF3
9 avian influenza 10.8
10 bronchitis 10.5
11 laryngotracheitis 10.3
12 adenocarcinoma 10.2
13 respiratory syncytial virus infectious disease 10.2 IFNB1 NEU1
14 oral erosive lichen 10.2 IFNA1 IFNB1
15 hypercarotenemia and vitamin a deficiency, autosomal dominant 10.2
16 lung cancer 10.2
17 keratomalacia 10.2
18 murray valley encephalitis 10.2 IFNA1 IFNB1
19 glioma 10.2
20 fibromatosis, gingival, 1 10.2 CD36 TGFB1
21 trench fever 10.1 CCDC130 TNF
22 kashin-beck disease 10.1 BAX TNF
23 marburg hemorrhagic fever 10.1 IFNB1 TNF
24 farmer's lung 10.1 CD36 TNF
25 null-cell leukemia 10.1 IFNA1 TNF
26 chronic graft versus host disease 10.1 CD36 TNF
27 lung cancer susceptibility 3 10.1
28 stomatitis 10.1
29 laryngitis 10.1 TGFB1 TNF
30 listeria meningitis 10.0 IFNB1 TNF
31 clonorchiasis 10.0 TGFB1 TNF
32 japanese encephalitis 10.0 DDX58 IFNB1 TNF
33 herpangina 10.0 IFNA1 IFNB1
34 prostate cancer 10.0
35 rabies 10.0
36 melanoma 10.0
37 encephalitis 10.0
38 posterior urethral valves 10.0 TGFB1 TNF
39 relapsing-remitting multiple sclerosis 10.0 IFNA1 IFNB1 TNF
40 demyelinating disease 10.0 IFNA1 IFNB1 TNF
41 breast disease 9.9 BAX TGFB1 TNF
42 septicemic plague 9.9 IFNB1 IRF3
43 noonan syndrome 9 9.9 IFNA1 IRF3
44 colorectal cancer 9.9
45 hepatocellular carcinoma 9.9
46 gastric cancer 9.9
47 deficiency anemia 9.9
48 arthritis 9.9
49 pancreas adenocarcinoma 9.9
50 lymphoma 9.9

Graphical network of the top 20 diseases related to Newcastle Disease:



Diseases related to Newcastle Disease

Symptoms & Phenotypes for Newcastle Disease

Symptoms:

12
  • conjunctivitis
  • headache
  • coughing
  • watery diarrhea
  • lacrimation in humans
  • gasping
  • twisting of head
  • circling
  • complete paralysis
  • reduced egg production in birds

UMLS symptoms related to Newcastle Disease:


discharge from eye

GenomeRNAi Phenotypes related to Newcastle Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Upregulation of RLR pathway after Sendai virus (SeV) infection GR00302-A 8.92 DDX58 IRF3 RAN RELA

MGI Mouse Phenotypes related to Newcastle Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.91 BAX CD36 DDX58 IFNB1 IRF3 NEU1
2 liver/biliary system MP:0005370 9.63 CD36 DDX58 NEU1 RELA TGFB1 TNF
3 muscle MP:0005369 9.43 BAX CD36 NEU1 RELA TGFB1 TNF
4 skeleton MP:0005390 9.17 BAX CD36 IFNB1 NEU1 RELA TGFB1

Drugs & Therapeutics for Newcastle Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Newcastle Disease Virus (NDV) for Cancer Patients Resistant to Conventional Anti-cancer Modalities Withdrawn NCT00348842 Phase 2

Search NIH Clinical Center for Newcastle Disease

Cochrane evidence based reviews: newcastle disease

Genetic Tests for Newcastle Disease

Anatomical Context for Newcastle Disease

MalaCards organs/tissues related to Newcastle Disease:

41
Lung, Testes, Eye, T Cells, Prostate, Bone, Thyroid

Publications for Newcastle Disease

Articles related to Newcastle Disease:

(show top 50) (show all 1142)
# Title Authors Year
1
Drivers of vaccination preferences to protect a low-value livestock resource: Willingness to pay for Newcastle disease vaccines by smallholder households. ( 30478006 )
2019
2
Molecular characterization of hemagglutinin-neuraminidase fragment gene of Newcastle disease virus isolated from periodically-vaccinated farms. ( 29915505 )
2018
3
Newcastle disease virus co-expressing interleukin 7 and interleukin 15 modified tumor cells as a vaccine for cancer immunotherapy. ( 29224228 )
2018
4
Evaluation of spray and oral delivery of Newcastle disease I2 vaccine in chicken reared by smallholder farmers in central Ethiopia. ( 29439696 )
2018
5
Recombinant Newcastle disease viruses with targets for PCR diagnostics for rinderpest and peste des petits ruminants. ( 29906491 )
2018
6
Acute phase proteins and stress markers in the immediate response to a combined vaccination against Newcastle disease and infectious bronchitis viruses in specific pathogen free (SPF) layer chicks. ( 29182756 )
2018
7
Newcastle disease virus induces G<sub>0</sub>/G<sub>1</sub> cell cycle arrest in asynchronously growing cells. ( 29793075 )
2018
8
Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines. ( 29352240 )
2018
9
Erratum: Author Correction: Newcastle disease virus-based H5 influenza vaccine protects chickens from lethal challenge with a highly pathogenic H5N2 avian influenza virus. ( 29799537 )
2018
10
Emergence of a Virulent Genotype VIIi of Newcastle Disease Virus in Iran. ( 29954188 )
2018
11
Pathological and molecular investigation of velogenic viscerotropic Newcastle disease outbreak in a vaccinated chicken flocks. ( 29911151 )
2018
12
Antitumor effect of the Newcastle disease viral hemagglutinin-neuraminidase gene is expressed through an oncolytic adenovirus effect in osteosarcoma cells. ( 29438228 )
2018
13
Can genotype mismatch really affect the level of protection conferred by Newcastle disease vaccines against heterologous virulent strains? ( 29843999 )
2018
14
Effects of Newcastle Disease Virus Infection on Chicken Intestinal Intraepithelial Natural Killer Cells. ( 29973933 )
2018
15
Whole-genome sequencing of genotype VI Newcastle disease viruses from formalin-fixed paraffin-embedded tissues from wild pigeons reveals continuous evolution and previously unrecognized genetic diversity in the U.S. ( 29329546 )
2018
16
Immune responses of mature chicken bone-marrow-derived dendritic cells infected with Newcastle disease virus strains with differing pathogenicity. ( 29397456 )
2018
17
Risk factors for Newcastle disease in broiler farms in Israel. ( 29290305 )
2018
18
Diagnosis of virulent Newcastle disease in southern California, May 2018. ( 29952744 )
2018
19
Modified Newcastle Disease virus as an improved vaccine vector against Simian Immunodeficiency virus. ( 29895833 )
2018
20
Regulation of Constitutive Interferon-Stimulated Genes (Isgs) in Tumor Cells Contributes to Enhanced Antitumor Response of Newcastle Disease Virus-Infected Tumor Vaccines. ( 29882780 )
2018
21
Newcastle Disease Virus-Based Vectored Vaccine against Poliomyelitis. ( 29925653 )
2018
22
Evaluation of the effect of live LaSota Newcastle disease virus vaccine as primary immunization on immune development in broilers. ( 29211892 )
2018
23
Supplementation of Vitamin E Protects Chickens from Newcastle Disease Virus-Mediated Exacerbation of Intestinal Oxidative Stress and Tissue Damage. ( 29949793 )
2018
24
Newcastle Disease Virus Infection Interferes With the Formation of Intestinal Microflora in Newly Hatched Specific-Pathogen-Free Chicks. ( 29867811 )
2018
25
Potent Inhibitors against Newcastle Disease Virus Hemagglutinin-Neuraminidase. ( 29231283 )
2018
26
Effect of adjuvants on in ovo vaccination against Newcastle disease on hatchability, performance and antibody titres in commercial pullets. ( 29740890 )
2018
27
Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine. ( 29399179 )
2018
28
Dendritic cell targeted HIV-1 gag protein vaccine provides help to a recombinant Newcastle disease virus vectored vaccine including mobilization of protective CD8<sup>+</sup>T cells. ( 29205929 )
2018
29
Saponin-adjuvanted vaccine protects chickens against velogenic Newcastle disease virus. ( 29968048 )
2018
30
Newcastle disease virus: is an updated attenuated vaccine needed? ( 29897786 )
2018
31
Validation of immunomodulatory effects of lipopolysaccharide through expression profiling of Th1 and Th2 biased genes in Newcastle disease virus vaccinated indigenous chicken. ( 29805207 )
2018
32
Recombinant oncolytic Newcastle disease virus displays antitumor activities in anaplastic thyroid cancer cells. ( 30021550 )
2018
33
Prevalence of avian influenza, Newcastle disease, and infectious bronchitis viruses in broiler flocks infected with multifactorial respiratory diseases in Iran, 2015-2016. ( 30377950 )
2018
34
Interaction between avian influenza subtype H9N2 and Newcastle disease virus vaccine strain (LaSota) in chickens. ( 30458777 )
2018
35
Establishment of xMAP for the simultaneous detection of antibodies to Newcastle disease virus and avian influenza virus. ( 30476286 )
2018
36
Prime-boost vaccination strategy against avian influenza and Newcastle disease viruses reduces shedding of the challenge viruses. ( 30159367 )
2018
37
Chimeric Newcastle disease virus-vectored vaccine protects chickens against H9N2 avian influenza virus in the presence of pre-existing NDV immunity. ( 30187143 )
2018
38
Maternal antibody inhibition of recombinant Newcastle disease virus vectored vaccine in a primary or booster avian influenza vaccination program of broiler chickens. ( 30241684 )
2018
39
Detection of Newcastle Disease, H9N2 Avian Influenza, and Infectious Bronchitis Viruses in Respiratory Diseases in Backyard Chickens in Ahvaz, Iran, in 2014-2015. ( 30256035 )
2018
40
Chickens Expressing IFIT5 Ameliorate Clinical Outcome and Pathology of Highly Pathogenic Avian Influenza and Velogenic Newcastle Disease Viruses. ( 30271403 )
2018
41
Virucidal activity of a quaternary ammonium compound associated with calcium hydroxide on avian influenza virus, Newcastle disease virus and infectious bursal disease virus. ( 29540633 )
2018
42
Epidemiological investigation of H9 avian influenza virus, Newcastle disease virus, Tembusu virus, goose parvovirus and goose circovirus infection of geese in China. ( 29134777 )
2018
43
Lack of Detection of Avian Influenza, Newcastle Disease, and West Nile Viruses in Wild Birds of Northeastern Brazil. ( 29148889 )
2018
44
A Recombinant Newcastle Disease Virus (NDV) Expressing S Protein of Infectious Bronchitis Virus (IBV) Protects Chickens against IBV and NDV. ( 30097608 )
2018
45
Burden of exposure to infectious bursal disease virus, infectious bronchitis virus, Newcastle disease virus, Mycoplasma gallisepticum, and intestinal parasites in introduced broiler chickens on the Galapagos. ( 30248128 )
2018
46
Newcastle disease virus enhances the growth-inhibiting and proapoptotic effects of temozolomide on glioblastoma cells in vitro and in vivo. ( 30065314 )
2018
47
Chicken infectious anemia virus helps fowl adenovirus break the protection of maternal antibody and cause inclusion body hepatitis-hydropericardium syndrome in layers after using co-contaminated Newcastle disease virus-attenuated vaccine. ( 30358862 )
2018
48
Recombinant infectious laryngotracheitis virus expressing Newcastle disease virus F protein protects chickens against infectious laryngotracheitis virus and Newcastle disease virus challenge. ( 30448332 )
2018
49
Molecular Characterization of Newcastle Disease Virus from Backyard Poultry Farms and Live Bird Markets in Kenya. ( 30154854 )
2018
50
α2,3- and α2,6-linked sialic acids are important for cell binding and replication of Newcastle disease virus in chicken primary neuronal cells. ( 30160139 )
2018

Variations for Newcastle Disease

Expression for Newcastle Disease

Search GEO for disease gene expression data for Newcastle Disease.

Pathways for Newcastle Disease

Pathways related to Newcastle Disease according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CD36 DDX58 IFNA1 IFNB1 IRF3 NEU1
2
Show member pathways
13.08 CD36 DDX58 IFNA1 IFNB1 IRF3 RELA
3
Show member pathways
12.9 IFNA1 IFNB1 IRF3 RELA TGFB1 TNF
4
Show member pathways
12.89 BAX IFNA1 IFNB1 IRF3 RELA TNF
5
Show member pathways
12.74 BAX DDX58 IFNA1 IFNB1 IRF3 RELA
6
Show member pathways
12.6 DDX58 IFNA1 IFNB1 IRF3 RELA TNF
7
Show member pathways
12.58 BAX RAN RELA TNF
8
Show member pathways
12.55 DDX58 IFNA1 IFNB1 IRF3 RELA TNF
9 12.46 DDX58 IFNA1 IRF3 RELA TNF
10
Show member pathways
12.44 DDX58 IFNA1 IFNB1 IRF3
11 12.26 BAX RAN RELA TGFB1 TNF
12
Show member pathways
12.17 IFNA1 IFNB1 IRF3 TGFB1 TNF
13
Show member pathways
12.13 BAX IFNA1 IFNB1 TNF
14
Show member pathways
12.09 IFNB1 RELA TNF
15 12.08 BAX TGFB1 TNF
16 12.06 IFNA1 IFNB1 IRF3
17
Show member pathways
12 CD36 IFNB1 IRF3 RELA TNF
18 11.96 RAN RELA TGFB1
19 11.94 IFNB1 RELA TGFB1 TNF
20 11.92 BAX RELA TNF
21 11.9 CD36 TGFB1 TNF
22 11.89 BAX IFNA1 IFNB1 RELA TGFB1 TNF
23 11.88 IFNB1 RELA TNF
24
Show member pathways
11.87 CD36 RELA TNF
25 11.8 RELA TGFB1 TNF
26 11.8 DDX58 RELA TNF
27 11.77 BAX RELA TGFB1 TNF
28 11.69 IRF3 RELA TNF
29 11.68 IFNB1 TGFB1 TNF
30 11.66 CD36 TGFB1 TNF
31 11.64 CD36 RELA TNF
32 11.61 RAN RELA TNF
33 11.6 RAN RELA TGFB1
34 11.55 DDX58 IFNA1 IFNB1 IRF3 RELA TNF
35 11.48 CD36 TGFB1 TNF
36 11.47 BAX DDX58 IFNA1 IFNB1 IRF3 RELA
37 11.46 CD36 RELA TNF
38 11.46 BAX TGFB1 TNF
39 11.4 BAX RELA TNF
40 11.16 IFNB1 TGFB1 TNF
41 11.07 IFNB1 RELA TNF
42
Show member pathways
11.05 DDX58 IRF3
43 11.03 RAN RELA TNF
44 10.96 BAX TNF
45 10.88 CD36 TNF
46 10.8 TGFB1 TNF

GO Terms for Newcastle Disease

Biological processes related to Newcastle Disease according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.97 IFNA1 IFNB1 TGFB1 TNF
2 positive regulation of gene expression GO:0010628 9.96 CD36 DDX58 TGFB1 TNF
3 viral process GO:0016032 9.93 BAX DDX58 IRF3 RAN RELA
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.83 CD36 IRF3 RELA TNF
5 response to organic cyclic compound GO:0014070 9.82 RAN RELA TGFB1
6 response to bacterium GO:0009617 9.8 CD36 IRF3 RELA
7 cellular response to lipopolysaccharide GO:0071222 9.8 CD36 IRF3 RELA TNF
8 response to organic substance GO:0010033 9.79 RELA TGFB1 TNF
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.76 CD36 RELA TGFB1 TNF
10 type I interferon signaling pathway GO:0060337 9.74 IFNA1 IFNB1 IRF3
11 positive regulation of interleukin-6 production GO:0032755 9.73 CD36 DDX58 TNF
12 defense response GO:0006952 9.73 IFNA1 IFNB1 RELA TNF
13 humoral immune response GO:0006959 9.72 IFNA1 IFNB1 TNF
14 extrinsic apoptotic signaling pathway GO:0097191 9.69 BAX TGFB1 TNF
15 positive regulation of interferon-beta production GO:0032728 9.68 DDX58 IRF3
16 negative regulation of myoblast differentiation GO:0045662 9.67 TGFB1 TNF
17 positive regulation of protein complex assembly GO:0031334 9.67 TGFB1 TNF
18 T cell activation involved in immune response GO:0002286 9.66 IFNA1 IFNB1
19 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.65 IFNA1 IFNB1
20 natural killer cell activation involved in immune response GO:0002323 9.65 IFNA1 IFNB1
21 cellular response to exogenous dsRNA GO:0071360 9.64 DDX58 IFNB1
22 negative regulation of growth of symbiont in host GO:0044130 9.63 CD36 TNF
23 membrane protein intracellular domain proteolysis GO:0031293 9.62 RELA TGFB1
24 positive regulation of interferon-alpha production GO:0032727 9.62 DDX58 IRF3
25 response to virus GO:0009615 9.62 CCDC130 DDX58 IFNB1 TNF
26 cellular response to lipoteichoic acid GO:0071223 9.6 CD36 RELA
27 regulation of protein heterodimerization activity GO:0043497 9.59 BAX CD36
28 response to salt stress GO:0009651 9.58 BAX TNF
29 cellular response to nicotine GO:0071316 9.58 RELA TNF
30 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 IRF3 TGFB1 TNF
31 defense response to virus GO:0051607 9.55 DDX58 IFNA1 IFNB1 IRF3 RELA
32 positive regulation of mononuclear cell migration GO:0071677 9.48 TGFB1 TNF
33 protein import into nucleus, translocation GO:0000060 9.43 RAN TGFB1 TNF
34 cytokine-mediated signaling pathway GO:0019221 9.43 CD36 IFNA1 IFNB1 RELA TGFB1 TNF
35 positive regulation of blood microparticle formation GO:2000334 9.37 CD36 TNF
36 response to exogenous dsRNA GO:0043330 8.92 DDX58 IFNA1 IFNB1 IRF3
37 positive regulation of transcription by RNA polymerase II GO:0045944 10.08 DDX58 IFNB1 IRF3 RELA TGFB1 TNF
38 negative regulation of transcription by RNA polymerase II GO:0000122 10.04 CD36 IRF3 RELA TGFB1 TNF

Molecular functions related to Newcastle Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 BAX DDX58 IRF3 RELA TGFB1 TNF
2 type I interferon receptor binding GO:0005132 9.16 IFNA1 IFNB1
3 cytokine activity GO:0005125 8.92 IFNA1 IFNB1 TGFB1 TNF

Sources for Newcastle Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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