Aliases & Classifications for Newcastle Disease

MalaCards integrated aliases for Newcastle Disease:

Name: Newcastle Disease 12 54 43 15 17 71
Newcastle's Disease 12
Pseudo-Fowlpest 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2929
MeSH 43 D009521
NCIt 49 C34849
SNOMED-CT 67 89366008
UMLS 71 C0027983

Summaries for Newcastle Disease

Disease Ontology : 12 A viral infectious disease that results in infection in birds and humans, has material basis in Newcastle disease virus, which is transmitted by contact with feces and urine of an infected bird, or transmitted by fomites. The infection has symptom conjunctivitis, has symptom headache, and has symptom lacrimation in humans, and has symptom gasping, has symptom coughing, has symptom twisting of head and neck, has symptom circling, has symptom complete paralysis, has symptom watery diarrhea, and has symptom reduced egg production in birds.

MalaCards based summary : Newcastle Disease, also known as newcastle's disease, is related to parainfluenza virus type 3 and stomatitis, and has symptoms including headache, conjunctivitis and coughing. An important gene associated with Newcastle Disease is IFNA1 (Interferon Alpha 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include testes, lung and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Newcastle Disease

Diseases related to Newcastle Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 parainfluenza virus type 3 30.8 NEU1 IFNB1
2 stomatitis 30.6 TNF IFNA1 DDX58
3 swine influenza 30.2 TNF NEU1 IFNA1 DDX58
4 vaccinia 30.1 TNF IRF7 IRF3 IFNB1 IFNA1
5 rubella 30.1 TNF TLR3 IFNB1 DDX58
6 west nile virus 30.0 TLR3 IRF3 IFNA1 DDX58
7 mouth disease 29.7 TLR3 IRF3 IFNA1 DDX58
8 avian influenza 29.7 TNFSF10 TNF NEU1 IVNS1ABP IRF7 IFNA1
9 viral encephalitis 29.7 TNF TLR3 CXCL10
10 encephalitis 29.6 TNF TLR3 IRF3 DDX58 CXCL10
11 measles 29.4 TNF TLR3 IRF7 IRF3 IFNB1 IFNA1
12 leprosy 3 29.4 TNF TLR3 CXCL10
13 rabies 29.3 TLR3 IRF7 IRF3 IFNA1 DDX58 CXCL10
14 japanese encephalitis 29.3 TNF TLR3 IVNS1ABP IFNB1 CXCL10
15 hepatitis a 29.3 TNF TLR3 IFNA1 CXCL10
16 mumps 29.2 TNF TLR3 IRF1 IFNB1 IFNA1 CXCL10
17 crimean-congo hemorrhagic fever 29.1 TNF DDX58 CXCL10 CASP3
18 myeloma, multiple 29.0 TNFSF10 TNF TLR3 IFNA1 CASP3
19 herpes simplex 29.0 TNF TLR3 IRF7 IRF3 IFNB1 IFNA1
20 human immunodeficiency virus type 1 28.9 TNF TLR3 IRF3 IFNA1 CXCL10
21 severe acute respiratory syndrome 28.7 TNF IRF3 IFNB1 IFNA1 DDX58 CXCL10
22 thrombocytopenia 28.7 TNF IFNB1 IFNA1 CXCL10 CASP3
23 influenza 28.4 TNF TLR3 NEU1 IVNS1ABP IRF7 IRF3
24 viral infectious disease 25.9 TNFSF10 TNF TLR3 NEU1 NCR2 NCR1
25 bronchitis 10.8
26 plague 10.5
27 oral erosive lichen 10.5 IFNB1 IFNA1
28 laryngotracheitis 10.4
29 conjunctivitis 10.4
30 clear cell adenocarcinoma of the ovary 10.4 NEU1 IFI27
31 diarrhea 10.4
32 cholera 10.4
33 glioblastoma multiforme 10.3
34 torticollis 10.3
35 pfeiffer syndrome 10.3
36 listeria meningitis 10.3 TNF IFNB1
37 48,xyyy 10.3
38 null-cell leukemia 10.2 TNF IFNA1
39 hypercarotenemia and vitamin a deficiency, autosomal dominant 10.2
40 keratomalacia 10.2
41 allergic hypersensitivity disease 10.2
42 melanoma 10.2
43 fibrosarcoma 10.2
44 glioma 10.2
45 glial tumor 10.2
46 penile disease 10.2 TNF TLR3 IFNA1
47 tracheitis 10.2
48 carcinoma showing thymus-like differentiation 10.2
49 hepatitis e 10.2 TNF TLR3 DDX58
50 lung cancer susceptibility 3 10.2

Graphical network of the top 20 diseases related to Newcastle Disease:



Diseases related to Newcastle Disease

Symptoms & Phenotypes for Newcastle Disease

Symptoms:

12
  • headache
  • conjunctivitis
  • coughing
  • watery diarrhea
  • lacrimation in humans
  • gasping
  • twisting of head
  • circling
  • complete paralysis
  • reduced egg production in birds

UMLS symptoms related to Newcastle Disease:


discharge from eye

GenomeRNAi Phenotypes related to Newcastle Disease according to GeneCards Suite gene sharing:

26 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.2 RAN
2 Increased shRNA abundance (Z-score > 2) GR00366-A-13 10.2 NCR1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-131 10.2 NCR1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.2 NCR1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.2 RAN
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.2 RAN
7 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.2 IRF1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.2 IRF1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-158 10.2 IRF1 IVNS1ABP NCR1 RAN
10 Increased shRNA abundance (Z-score > 2) GR00366-A-159 10.2 IVNS1ABP RAN
11 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.2 RAN
12 Increased shRNA abundance (Z-score > 2) GR00366-A-173 10.2 IRF1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.2 RAN
14 Increased shRNA abundance (Z-score > 2) GR00366-A-180 10.2 IRF1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-200 10.2 IRF1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-201 10.2 RAN
17 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.2 IVNS1ABP
18 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.2 IRF1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.2 RAN
20 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.2 IRF1 RAN
21 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.2 IRF1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-54 10.2 IRF1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-6 10.2 IRF1 RAN
24 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.2 RAN
25 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.2 RAN
26 Increased shRNA abundance (Z-score > 2) GR00366-A-76 10.2 IVNS1ABP
27 Increased shRNA abundance (Z-score > 2) GR00366-A-78 10.2 RAN
28 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.2 IRF1
29 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.2 IRF1
30 Upregulation of RLR pathway after Sendai virus (SeV) infection GR00302-A 8.92 CASP3 DDX58 IRF3 RAN

MGI Mouse Phenotypes related to Newcastle Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CASP3 CD36 CXCL10 DDX58 IFNB1 IRF1
2 homeostasis/metabolism MP:0005376 9.8 CASP3 CD36 CXCL10 DDX58 IFNB1 IRF1
3 immune system MP:0005387 9.44 CASP3 CD36 CXCL10 DDX58 IFNB1 IRF1

Drugs & Therapeutics for Newcastle Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II: Safety and Primary Efficacy of Clinical Application of Newcastle Disease Virus for the Treatment of Patients Resistant to All Conventional Modalities Withdrawn NCT00348842 Phase 2

Search NIH Clinical Center for Newcastle Disease

Cochrane evidence based reviews: newcastle disease

Genetic Tests for Newcastle Disease

Anatomical Context for Newcastle Disease

MalaCards organs/tissues related to Newcastle Disease:

40
Testes, Lung, T Cells, Brain, Kidney, Liver, Monocytes

Publications for Newcastle Disease

Articles related to Newcastle Disease:

(show top 50) (show all 6425)
# Title Authors PMID Year
1
Antiviral response dictated by choreographed cascade of transcription factors. 54 61
20164420 2010
2
The rinderpest virus non-structural C protein blocks the induction of type 1 interferon. 54 61
19108859 2009
3
Capsid protein of eastern equine encephalitis virus inhibits host cell gene expression. 54 61
17267491 2007
4
Influenza virus evades innate and adaptive immunity via the NS1 protein. 54 61
16775317 2006
5
In vitro-generated viral double-stranded RNA in contrast to polyinosinic:polycytidylic acid induces interferon-alpha in human plasmacytoid dendritic cells. 54 61
16623926 2006
6
The regulatory roles of cell surface sialylation and N-glycans in human B cell lymphoma cell adhesion to galectin-1. 54 61
16327992 2006
7
N(pro) of classical swine fever virus is an antagonist of double-stranded RNA-mediated apoptosis and IFN-alpha/beta induction. 54 61
16043207 2005
8
Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons. 54 61
15651759 2004
9
Newcastle disease virus neuraminidase primes neutrophils for stimulation by galectin-3 and formyl-Met-Leu-Phe. 54 61
15242763 2004
10
Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III. 54 61
14729348 2004
11
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. 54 61
14679297 2004
12
Two ways to induce innate immune responses in human PBMCs: paracrine stimulation of IFN-alpha responses by viral protein or dsRNA. 54 61
12888903 2003
13
Differential expression of IFN-alpha subtypes in human PBMC: evaluation of novel real-time PCR assays. 54 61
12738374 2003
14
Dendritic cells pulsed with viral oncolysates potently stimulate autologous T cells from cancer patients. 54 61
12239606 2002
15
Production of interferons and change of the lymphocyte subpopulation phenotype in peripheral blood at cervical papillomavirus infection. 54 61
12630331 2002
16
[Time course of interferon status of patients with herpetic keratitis during treatment with actipol, a new inteferon inducer]. 54 61
11339038 2001
17
Virus-receptor interactions of human parainfluenza viruses types 1, 2 and 3. 54 61
10545258 1999
18
Increased cortisol levels in human umbilical cord blood inhibit interferon alpha production of neonates. 54 61
10416130 1999
19
Effect of granulocyte colony stimulating factor treatment on ex vivo cytokine production by blood cells of patients after chemotherapy or radiotherapy. 54 61
11729831 1999
20
IP-10 gene transcription by virus in astrocytes requires cooperation of ISRE with adjacent kappaB site but not IRF-1 or viral transcription. 54 61
9858321 1998
21
Abnormal surface expression of sialoglycans on B lymphocyte cell lines from patients with carbohydrate deficient glycoprotein syndrome I A (CDGS I A). 54 61
9719677 1998
22
Exogenous and endogenous IL-10 regulate IFN-alpha production by peripheral blood mononuclear cells in response to viral stimulation. 54 61
9637497 1998
23
Culture of human amniotic cells: a system to study interferon production. 54 61
9639327 1998
24
[Cytokine release and changes in mononuclear cells in peripheral blood under the influence of general anesthesia]. 54 61
9645277 1998
25
Constitutive and induced cytokine production by human placenta and amniotic membrane at term. 54 61
9250707 1997
26
Correlation between interferon production and clinical disease activity in patients with multiple sclerosis. 54 61
9258768 1997
27
Immunoregulatory effects of morphine on human lymphocytes. 54 61
9067644 1997
28
Loss ability to produce IFN-alpha in response to HIV-1 as monocytes differentiate into macrophages. Induction through a mechanism independent of double-stranded RNA. 54 61
8786308 1996
29
Long-term assessment of interferon responses in the HIV+ and AIDS patients. 54 61
9017150 1996
30
Tumor necrosis factor and interferon production by peripheral blood leukocytes of patients with alcoholic cirrhosis. 54 61
8915512 1996
31
Interferon production by peripheral blood leukocytes of patients with acute myeloid leukemia. 54 61
8915515 1996
32
Regulatory mechanisms of MuRantes and CRG-2 chemokine gene induction in central nervous system glial cells by virus. 54 61
8903850 1995
33
Production of interferons and lymphokines in leukocyte cultures of patients with schizophrenia. 54 61
7543276 1995
34
Influence of various factors on interferon-alpha production in cultures of human leukocytes. 54 61
7930756 1994
35
IFN and virus-inducible expression of an immediate early gene, crg-2/IP-10, and a delayed gene, I-A alpha in astrocytes and microglia. 54 61
8301141 1994
36
Human trophoblast interferons. 54 61
7506512 1993
37
Deficient interferon-alpha response of newborns in comparison to adults. 54 61
8391859 1993
38
Differential interferon production in human first and third trimester trophoblast cultures stimulated with viruses. 54 61
7685097 1993
39
Interferon-beta. A potential autocrine regulator of human vascular smooth muscle cell growth. 54 61
1602741 1992
40
Deficiency in interferon production of peripheral blood leukocytes from patients with non-Hodgkin lymphoma. 54 61
1379288 1992
41
Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes. 54 61
1371248 1992
42
GMP-140 binds to a glycoprotein receptor on human neutrophils: evidence for a lectin-like interaction. 54 61
1704009 1991
43
Effects of long-term zidovudine treatment on cell-mediated immune response and lymphokine production. 54 61
1704062 1991
44
Regulation of cytokine and viral gene expression in monocytes infected with the human immunodeficiency virus. 54 61
1883515 1991
45
A selective defect of interferon alpha production in human immunodeficiency virus-infected monocytes. 54 61
2264889 1990
46
Comparisons of peripheral blood and hepatic lymphocyte subpopulations and interferon production in chronic viral hepatitis. 54 61
1726220 1990
47
Hyporesponsiveness of human alveolar leukocytes to interferon-alpha and interferon-gamma inducers. 54 61
2125576 1990
48
Long-term effects of 2'-deoxycoformycin treatment on cytokine production in patients with hairy cell leukemia. 54 61
1697012 1990
49
Corrigendum to "Evaluation of imidazole and its derivative against Newcastle disease virus infection in chicken: A drug repurposing approach" [Virus Res. (2019) 260 114-122]. 61
31972472 2020
50
Effect of omega-3 rich diet on the response of Japanese quails (Coturnix coturnix japonica) infected with Newcastle disease virus or avian influenza virus H9N2. 61
31712184 2020

Variations for Newcastle Disease

Expression for Newcastle Disease

Search GEO for disease gene expression data for Newcastle Disease.

Pathways for Newcastle Disease

Pathways related to Newcastle Disease according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 TNF TLR3 NEU1 NCR2 NCR1 IRF7
2
Show member pathways
13.11 TNF IRF7 IRF3 IRF1 IFNB1 IFNA1
3
Show member pathways
13.08 TNF TLR3 IRF7 IRF3 IFNB1 IFNA1
4
Show member pathways
12.96 TNF TLR3 IRF3 IRF1 IFNB1 IFNA1
5
Show member pathways
12.91 TNF TLR3 IRF7 IRF3 IFNB1 IFNA1
6
Show member pathways
12.78 TNFSF10 TNF IRF7 IRF3 IRF1 CASP3
7 12.61 TNF TLR3 IRF7 IRF3 IFNB1 IFNA1
8
Show member pathways
12.44 IRF7 IRF3 IRF1 IFNB1 IFNA1 IFI27
9
Show member pathways
12.39 TNFSF10 TNF NCR2 NCR1 IFNB1 IFNA1
10
Show member pathways
12.35 TLR3 IRF7 IRF3 DDX58
11 12.27 TNF TLR3 IRF7 IRF3 IRF1 IFNA1
12
Show member pathways
12.27 TNF TLR3 IRF7 IRF3 IRF1 IFNB1
13
Show member pathways
12.24 TNF TLR3 IRF3 IRF1
14
Show member pathways
12.23 TNF TLR3 IRF7 IRF3 IFNB1 CD36
15 12.21 TNF IRF7 IRF3 IFNB1 IFNA1
16
Show member pathways
12.21 TNF IRF7 IRF3 IRF1 IFNB1 IFNA1
17 12.18 TNF IFNB1 IFNA1 CASP3
18
Show member pathways
12.18 TNFSF10 TNF TLR3 IFNB1 IFNA1
19
Show member pathways
12.14 TNF IRF1 IFNB1 CXCL10
20 12.13 IRF7 IRF3 IRF1 IFNB1 IFNA1
21
Show member pathways
12.03 TNFSF10 TNF TLR3 IRF7 IRF3 IFNB1
22 11.97 TNF NCR2 NCR1 CD36
23 11.96 TNF IRF1 IFNB1 CXCL10 CASP3
24 11.85 IRF7 IRF1 IFNB1
25 11.76 TNF IRF3 IRF1 CASP3
26 11.71 TNF NCR2 NCR1
27 11.66 TNF CXCL10 CD36
28 11.46 TNFSF10 IFNB1 IFNA1 CASP3
29 11.36 IRF1 IFNB1 CXCL10
30
Show member pathways
11.13 IRF7 IRF3 DDX58
31 10.85 TNF CD36

GO Terms for Newcastle Disease

Biological processes related to Newcastle Disease according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.18 TNF TLR3 IRF7 IRF3 IRF1 IFNB1
2 immune system process GO:0002376 10.09 TLR3 IRF7 IRF3 IRF1 IFI27 DDX58
3 viral process GO:0016032 10.06 RAN IVNS1ABP IRF7 IRF3 IFI27 DDX58
4 innate immune response GO:0045087 10.04 TLR3 NCR2 IRF7 IRF3 IRF1 IFI27
5 cell surface receptor signaling pathway GO:0007166 9.96 TNFSF10 IFNB1 CXCL10 CD36
6 regulation of immune response GO:0050776 9.96 NCR2 NCR1 IRF7 IRF1
7 blood coagulation GO:0007596 9.94 IRF1 IFNB1 IFNA1 CD36
8 cellular response to lipopolysaccharide GO:0071222 9.93 TNF IRF3 CXCL10 CD36
9 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 TNFSF10 TNF TLR3 IRF3 CD36
10 defense response GO:0006952 9.88 TNF TLR3 IFNB1 IFNA1 CXCL10
11 cytokine-mediated signaling pathway GO:0019221 9.88 TNF IFNB1 IFNA1 CXCL10 CD36 CASP3
12 interferon-gamma-mediated signaling pathway GO:0060333 9.83 IRF7 IRF3 IRF1
13 apoptotic signaling pathway GO:0097190 9.82 TNF TLR3 CASP3
14 humoral immune response GO:0006959 9.81 TNF IFNB1 IFNA1
15 positive regulation of interleukin-6 production GO:0032755 9.81 TNF TLR3 DDX58 CD36
16 extrinsic apoptotic signaling pathway GO:0097191 9.79 TNF TLR3 IFI27
17 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.77 TLR3 IRF7 IRF3
18 positive regulation of interleukin-8 production GO:0032757 9.77 TNF TLR3 DDX58
19 positive regulation of type I interferon production GO:0032481 9.73 TLR3 IRF7 IRF3 IRF1
20 response to exogenous dsRNA GO:0043330 9.72 TLR3 IRF3 IFNB1 IFNA1 DDX58
21 cellular response to interferon-beta GO:0035458 9.71 TLR3 IRF1 IFNB1
22 positive regulation of type I interferon-mediated signaling pathway GO:0060340 9.67 IRF7 IRF3
23 regulation of type I interferon production GO:0032479 9.67 IRF7 IRF3
24 positive regulation of chemokine biosynthetic process GO:0045080 9.67 TNF TLR3
25 cellular response to exogenous dsRNA GO:0071360 9.67 TLR3 IRF3 IFNB1 DDX58
26 regulation of adaptive immune response GO:0002819 9.65 IRF7 IRF1
27 positive regulation of interferon-beta production GO:0032728 9.65 TLR3 IRF7 IRF3 IRF1 DDX58
28 necroptotic signaling pathway GO:0097527 9.63 TNF TLR3
29 positive regulation of interferon-alpha production GO:0032727 9.63 IRF7 IRF3 DDX58
30 type I interferon signaling pathway GO:0060337 9.63 IRF7 IRF3 IRF1 IFNB1 IFNA1 IFI27
31 detection of virus GO:0009597 9.62 TLR3 DDX58
32 MDA-5 signaling pathway GO:0039530 9.61 IRF7 IRF3
33 defense response to virus GO:0051607 9.61 TLR3 IRF7 IRF3 IRF1 IFNB1 IFNA1
34 positive regulation of blood microparticle formation GO:2000334 9.57 TNF CD36
35 type I interferon biosynthetic process GO:0045351 9.56 IRF7 IRF3
36 regulation of MyD88-dependent toll-like receptor signaling pathway GO:0034124 9.55 IRF7 IRF1
37 response to virus GO:0009615 9.23 TNF TLR3 IVNS1ABP IRF7 IFNB1 DDX58

Molecular functions related to Newcastle Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TNFSF10 TNF TLR3 RAN NEU1 NCR2
2 transcription regulatory region DNA binding GO:0044212 9.46 TNF IRF7 IRF3 IRF1
3 cytokine activity GO:0005125 9.02 TNFSF10 TNF IFNB1 IFNA1 CXCL10

Sources for Newcastle Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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