MCID: NCK004
MIFTS: 36

Nickel Allergic Contact Dermatitis

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Nickel Allergic Contact Dermatitis

MalaCards integrated aliases for Nickel Allergic Contact Dermatitis:

Name: Nickel Allergic Contact Dermatitis 12 15
Allergic Contact Dermatitis to Ni 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040046
ICD10 32 L23.0

Summaries for Nickel Allergic Contact Dermatitis

Disease Ontology : 12 An allergic contact dermatitis that has allergic trigger nickel atom.

MalaCards based summary : Nickel Allergic Contact Dermatitis, also known as allergic contact dermatitis to ni, is related to ige responsiveness, atopic and otitis media. An important gene associated with Nickel Allergic Contact Dermatitis is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drug Nickel has been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related phenotypes are digestive/alimentary and hematopoietic system

Related Diseases for Nickel Allergic Contact Dermatitis

Diseases related to Nickel Allergic Contact Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 520)
# Related Disease Score Top Affiliating Genes
1 ige responsiveness, atopic 30.1 IL5 IL4 IL13 IL10 IFNG
2 otitis media 30.1 IL5 IL4 IL17A IL10 IFNG
3 dermatitis 29.9 IL5 IL4 IL2 IL17A IL13 IL10
4 tetanus 29.5 IL9 IL5 IL4 IL2 IL13 IL10
5 contact dermatitis 28.7 IL9 IL5 IL4 IL22 IL2 IL17F
6 dermatitis, atopic 28.7 IL9 IL5 IL4 IL2 IL17A IL13
7 allergic contact dermatitis 28.7 IL9 IL5 IL4 IL26 IL22 IL17F
8 cefaclor allergy 10.4 IL5 IL13
9 cefuroxime allergy 10.4 IL5 IL13
10 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL5 IL13
11 respiratory syncytial virus infectious disease 10.4 IL5 IL13
12 tropical endomyocardial fibrosis 10.4 IL4 IL10
13 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.4 IL4 IL2
14 acute asthma 10.4 IL5 IL4
15 loeffler syndrome 10.4 IL5 IL13
16 virus associated hemophagocytic syndrome 10.4 IL4 IL2
17 orange allergy 10.3 IL5 IL13
18 acute gonococcal cervicitis 10.3 IL4 IL10
19 adenohypophysitis 10.3 GH1 CD4
20 neurodermatitis 10.3 IL4 IL13
21 nut allergy 10.3 IL5 IL4 IL13
22 palladium allergic contact dermatitis 10.3 IL17A IL10
23 autoimmune hepatitis type 1 10.3 IL4 IL10
24 neurosyphilis 10.3 IL17A IL10
25 eosinophilic gastritis 10.3 IL5 IL13
26 cork-handlers' disease 10.3 CD8A CD4
27 ceftriaxone allergy 10.3 IL5 IL13 IL10
28 kimura disease 10.3 IL5 IL4 IL13
29 vernal keratoconjunctivitis 10.3 IL5 IL4 IL13
30 aztreonam allergy 10.3 IL5 IL2 IL13
31 chronic rhinitis 10.3 IL5 IL4 IL13
32 cardiomyopathy, familial hypertrophic, 20 10.3 IL5 IL13 IL10
33 eosinophilic fasciitis 10.3 IL5 IFNG
34 early yaws 10.3 CD8A CD4
35 toxicodendron dermatitis 10.3 IL2 CD8A
36 cow milk allergy 10.3 IL5 IL4 IL10
37 ventilation pneumonitis 10.3 CD8A CD4
38 cough variant asthma 10.3 IL5 IL4
39 eosinophilic pneumonia 10.3 IL5 IL4 IL13
40 endomyocardial fibrosis 10.3 IL5 IL4 IL10
41 cerebral sinovenous thrombosis 10.3 IL17A IL10
42 asymptomatic neurosyphilis 10.3 IL17A CD4
43 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
44 pulmonary eosinophilia 10.3 IL5 IL4 IL13
45 meningovascular neurosyphilis 10.3 IL17A CD4
46 beta-lactam allergy 10.3 IL4 IL13 IL10
47 subacute lymphocytic thyroiditis 10.3 IL2 CD4
48 transient arthritis 10.3 IL17A CD4
49 latent syphilis 10.3 CD8A CD4
50 type 1 diabetes mellitus 23 10.3 CD8A CD4

Graphical network of the top 20 diseases related to Nickel Allergic Contact Dermatitis:



Diseases related to Nickel Allergic Contact Dermatitis

Symptoms & Phenotypes for Nickel Allergic Contact Dermatitis

MGI Mouse Phenotypes related to Nickel Allergic Contact Dermatitis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.29 AQP3 CD4 IFNG IL10 IL13 IL17A
2 hematopoietic system MP:0005397 10.27 CD4 CD8A IFNG IGF1 IL10 IL13
3 growth/size/body region MP:0005378 10.26 AQP3 CD4 IFNG IGF1 IL10 IL13
4 immune system MP:0005387 10.25 AQP3 CD4 CD8A IFNG IGF1 IL10
5 homeostasis/metabolism MP:0005376 10.21 AQP3 CD4 IFNG IGF1 IL10 IL13
6 endocrine/exocrine gland MP:0005379 10.19 CD4 CD8A IFNG IGF1 IL10 IL13
7 mortality/aging MP:0010768 10.1 AQP3 CD4 CD8A IFNG IGF1 IL10
8 integument MP:0010771 10.02 CD4 CD8A IFNG IGF1 IL10 IL13
9 no phenotypic analysis MP:0003012 9.76 CD4 IFNG IL10 IL13 IL17A IL2
10 neoplasm MP:0002006 9.73 IFNG IGF1 IL10 IL2 IL22 IL5
11 normal MP:0002873 9.56 CD4 CD8A IFNG IGF1 IL10 IL17F
12 respiratory system MP:0005388 9.36 AQP3 IFNG IGF1 IL10 IL13 IL17A

Drugs & Therapeutics for Nickel Allergic Contact Dermatitis

Drugs for Nickel Allergic Contact Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nickel Phase 2 7440-02-0 934

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double-Blind, Placebo-Controlled, Single-Center Study of the Intradermal Injection of rHuPH20 or Placebo in Subjects With Nickel Allergic Contact Dermatitis Completed NCT00928447 Phase 2 rHuPH20;Placebo

Search NIH Clinical Center for Nickel Allergic Contact Dermatitis

Genetic Tests for Nickel Allergic Contact Dermatitis

Anatomical Context for Nickel Allergic Contact Dermatitis

MalaCards organs/tissues related to Nickel Allergic Contact Dermatitis:

40
Skin, Lung, Bone, Lymph Node, Thymus, T Cells, Pituitary

Publications for Nickel Allergic Contact Dermatitis

Articles related to Nickel Allergic Contact Dermatitis:

(show all 26)
# Title Authors PMID Year
1
Nickel Sensitivity Is Associated with GH-IGF1 Axis Impairment and Pituitary Abnormalities on MRI in Overweight and Obese Subjects. 61
33419306 2020
2
Nickel Allergic Contact Dermatitis: Identification, Treatment, and Prevention. 61
32341178 2020
3
Does clinical testing support the current guidance definition of prolonged contact for nickel allergy? 61
30216527 2018
4
Evaluation of the profile of inflammatory cytokines, through immunohistochemistry, in the skin of patients with allergic contact dermatitis to nickel in the acute and chronic phases. 61
33261757 2018
5
Evaluation of the profile of inflammatory cytokines, through immunohistochemistry, in the skin of patients with allergic contact dermatitis to nickel in the acute and chronic phases. 61
30484527 2018
6
The Influence of Cultural Norms on Nickel Allergic Contact Dermatitis Prevalence Data. 61
29698359 2018
7
Systemic nickel allergy syndrome: nosologic framework and usefulness of diet regimen for diagnosis. 61
24067467 2013
8
Palladium-induced Th2 cytokine responses reflect skin test reactivity. 61
23067003 2012
9
Recurrent infections in children with nickel allergic contact dermatitis. 61
22217998 2011
10
Nickel allergy: localized, id, and systemic manifestations in children. 61
21087298 2011
11
Prevention of nickel allergy: the case for regulation? 61
19254659 2009
12
Genetics of nickel allergic contact dermatitis. 61
17725918 2007
13
Nickel release from nickel particles in artificial sweat. 61
17577373 2007
14
Dermal nickel exposure associated with coin handling and in various occupational settings: assessment using a newly developed finger immersion method. 61
16536808 2006
15
Impaired responses of peripheral blood mononuclear cells to nickel in patients with nickel-allergic contact dermatitis and concomitant atopic dermatitis. 61
15030331 2004
16
In vitro effects of nickel-sulphate on immune functions of normal and nickel-allergic subjects: a regulatory role for zinc. 61
14650623 2003
17
Nickel contact hypersensitivity in children. 61
11994170 2002
18
Repetitive usage testing with budesonide in experimental nickel--allergic contact dermatitis in individuals hypersensitive to budesonide. 61
11453905 2001
19
Lymphocyte subset changes in blood and gastrointestinal mucosa after oral nickel challenge in nickel-sensitized women. 61
11011919 2000
20
The genetics of allergic contact hypersensitivity to nickel. 61
10554057 1999
21
In vivo nickel allergic contact dermatitis: human model for topical therapeutics. 61
10208508 1999
22
An in vitro study of the use of chelating agents in cleaning nickel-contaminated human skin: an alternative approach to preventing nickel allergic contact dermatitis. 61
9817222 1998
23
Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells. 61
9764843 1998
24
T-cell vaccination in patients with nickel allergic contact dermatitis. 61
7615969 1995
25
Hyposensitization in nickel allergic contact dermatitis: clinical and immunologic monitoring. 61
7896945 1995
26
Kinetics and specificity of nickel hypersensitivity in the murine model. 61
7702492 1994

Variations for Nickel Allergic Contact Dermatitis

Expression for Nickel Allergic Contact Dermatitis

Search GEO for disease gene expression data for Nickel Allergic Contact Dermatitis.

Pathways for Nickel Allergic Contact Dermatitis

Pathways related to Nickel Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 IL9 IL5 IL4 IL22 IL2 IL17F
2
Show member pathways
13.84 IL9 IL5 IL4 IL26 IL22 IL2
3
Show member pathways
13.73 IL9 IL5 IL4 IL26 IL22 IL2
4
Show member pathways
13.6 IL9 IL5 IL4 IL26 IL22 IL2
5
Show member pathways
13.49 IL9 IL5 IL4 IL26 IL22 IL2
6
Show member pathways
13.42 IL9 IL5 IL4 IL22 IL2 IL17F
7
Show member pathways
13.36 IL9 IL5 IL4 IL26 IL22 IL2
8 12.87 IL5 IL4 IL2 IL13 IGF1 IFNG
9
Show member pathways
12.85 IL9 IL5 IL4 IL22 IL2 IL17A
10
Show member pathways
12.72 IL9 IL5 IL4 IL2 IL17A IL10
11
Show member pathways
12.67 IL5 IL4 IL22 IL2 IL17F IL17A
12
Show member pathways
12.66 IL2 IL17F IL17A IL10 IFNG CD4
13 12.64 IL4 IL2 IL17A IL10 IFNG CD8A
14
Show member pathways
12.63 IL4 IL2 IL10 IFNG CD4
15
Show member pathways
12.53 IL9 IL5 IL4 IL22 IL2 IL13
16
Show member pathways
12.43 IL5 IL4 IL17F IL17A IL13 IFNG
17
Show member pathways
12.31 IL9 IL5 IL4 IL2 IL17A IL13
18 12.17 IL5 IL4 IL2 IL10 IFNG CD8A
19 12.11 IL2 IL10 CD8A CD4
20 12.1 IL4 IL17F IL17A IL13 IL10
21
Show member pathways
12.09 IL4 IL2 IFNG CD8A CD4
22
Show member pathways
12 IL4 IL26 IL22 IL17F IL17A IFNG
23 11.96 IL5 IL4 CD8A CD4
24 11.92 IL5 IL4 IL2 IL13 IFNG
25
Show member pathways
11.88 IL2 IL17A IL10 IFNG CD4
26 11.87 IL2 IL10 IFNG CD8A CD4
27
Show member pathways
11.84 IL5 IL4 IL2 IFNG
28 11.76 IL5 IL4 IL13 IGF1
29 11.72 IL9 IL4 IL2
30 11.68 IL9 IL2 IGF1 GH1
31 11.68 IL5 IL4 IL10
32 11.66 IL5 IL4 IL10
33
Show member pathways
11.64 IL2 IFNG CD8A
34 11.55 IL4 IL13 IL10
35 11.45 IL5 IL4 IL2 IFNG
36
Show member pathways
11.4 IL2 IL10 IFNG
37 11.37 IL2 IL13 IFNG CD4
38 11.31 IL9 IL5 IL4 IL22 IL17A IL13
39 11.28 IL9 IL5 IL4 IL2 IL13 IL10
40 11.27 IL9 IL5 IL4 IL22 IL2 IL17A
41 11.22 IL9 IL5 IL4 IL2 IL13 IL10
42 11.16 IL5 IL4 IL2 IL13 IL10 IFNG
43 11.1 IL9 IL5 IL4 IL26 IL22 IL2
44 10.96 IL9 IL5 IL4 IL13

GO Terms for Nickel Allergic Contact Dermatitis

Cellular components related to Nickel Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 IL9 IL5 IL4 IL26 IL22 IL2
2 extracellular region GO:0005576 9.47 IL9 IL5 IL4 IL26 IL22 IL2

Biological processes related to Nickel Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.13 IL4 IL26 IL2 IL17F IL17A IL10
2 positive regulation of cell proliferation GO:0008284 9.97 IL9 IL5 IL4 IL2 IGF1 IFNG
3 adaptive immune response GO:0002250 9.93 IL2 IL17F IL17A IFNG CD8A CD4
4 inflammatory response GO:0006954 9.91 IL9 IL5 IL22 IL17F IL17A IL13
5 positive regulation of interleukin-6 production GO:0032755 9.84 IL17F IL17A IFNG
6 negative regulation of inflammatory response GO:0050728 9.84 IL4 IL2 IL13 IL10
7 defense response to Gram-negative bacterium GO:0050829 9.83 IL17F IL17A CD4
8 negative regulation of tumor necrosis factor production GO:0032720 9.81 IL4 IL10 IGF1
9 positive regulation of T cell proliferation GO:0042102 9.81 IL4 IL2 CD4
10 positive regulation of cytokine production GO:0001819 9.8 IL26 IL10 IFNG
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.78 IL5 IGF1 GH1 CD4
12 T cell activation GO:0042110 9.77 IL4 CD8A CD4
13 negative regulation of endothelial cell apoptotic process GO:2000352 9.72 IL4 IL13 IL10
14 microglial cell activation GO:0001774 9.7 IL4 IL13 IFNG
15 regulation of regulatory T cell differentiation GO:0045589 9.68 IL2 IFNG
16 positive regulation of signaling receptor activity GO:2000273 9.68 IL10 IFNG
17 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.67 IGF1 GH1
18 macrophage activation GO:0042116 9.67 IL4 IL13
19 negative regulation of neuroinflammatory response GO:0150079 9.67 IL4 IGF1
20 positive regulation of B cell proliferation GO:0030890 9.67 IL5 IL4 IL2 IL13
21 negative regulation of T-helper 17 cell differentiation GO:2000320 9.65 IL4 IL2
22 interleukin-17-mediated signaling pathway GO:0097400 9.65 IL17F IL17A
23 positive regulation of isotype switching to IgG isotypes GO:0048304 9.65 IL4 IL2
24 immune response GO:0006955 9.65 IL9 IL5 IL4 IL2 IL17A IL13
25 positive regulation of mast cell degranulation GO:0043306 9.64 IL4 IL13
26 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.63 IL4 IL2 IL13 IGF1 IFNG GH1
27 positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 9.62 IL17F IL17A
28 positive regulation of cellular respiration GO:1901857 9.62 IL4 IFNG
29 positive regulation of JAK-STAT cascade GO:0046427 9.62 IL5 IL26 IL10 GH1
30 neuroinflammatory response GO:0150076 9.61 IL4 IFNG
31 type 2 immune response GO:0042092 9.61 IL4 IL10
32 positive regulation of interleukin-23 production GO:0032747 9.6 IL17A IFNG
33 negative regulation of complement-dependent cytotoxicity GO:1903660 9.58 IL4 IL13
34 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL4 IL10 IFNG
35 positive regulation of plasma cell differentiation GO:1900100 9.57 IL2 IL10
36 regulation of isotype switching GO:0045191 9.56 IL4 IL10
37 positive regulation of immunoglobulin production GO:0002639 9.56 IL5 IL2 IL13 IL10
38 positive regulation of antimicrobial peptide production GO:0002225 9.51 IL17F IL17A
39 cytokine-mediated signaling pathway GO:0019221 9.32 IL5 IL4 IL26 IL22 IL2 IL17F

Molecular functions related to Nickel Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.5 IL9 IL5 IL4 IL2 IL10 IGF1
2 cytokine receptor binding GO:0005126 9.46 IL9 IL4 IL17F IL13
3 cytokine activity GO:0005125 9.36 IL9 IL5 IL4 IL26 IL22 IL2

Sources for Nickel Allergic Contact Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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