MCID: NCK004
MIFTS: 38

Nickel Allergic Contact Dermatitis

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Nickel Allergic Contact Dermatitis

MalaCards integrated aliases for Nickel Allergic Contact Dermatitis:

Name: Nickel Allergic Contact Dermatitis 12 15
Allergic Contact Dermatitis to Ni 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040046
ICD10 33 L23.0

Summaries for Nickel Allergic Contact Dermatitis

Disease Ontology : 12 An allergic contact dermatitis that has_allergic_trigger nickel atom.

MalaCards based summary : Nickel Allergic Contact Dermatitis, also known as allergic contact dermatitis to ni, is related to dermatitis and allergic contact dermatitis. An important gene associated with Nickel Allergic Contact Dermatitis is IL5 (Interleukin 5), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Nickel and Trace Elements have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lung, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Related Diseases for Nickel Allergic Contact Dermatitis

Diseases related to Nickel Allergic Contact Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 dermatitis 30.7 IFNG IL13 IL4 IL5
2 allergic contact dermatitis 30.4 IFNG IL10 IL4 IL5
3 contact dermatitis 30.4 IFNG IL10 IL4 IL5
4 dermatitis, atopic 29.4 IFNG IL10 IL13 IL4 IL5
5 common cold 10.2 IL13 IL5
6 eosinophilic pneumonia 10.2 IL13 IL5
7 cytokine deficiency 10.2 IL13 IL5
8 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL13 IL5
9 respiratory syncytial virus infectious disease 10.2 IL13 IL5
10 paragonimiasis 10.2 IL13 IL5
11 eosinophilic fasciitis 10.1 IFNG IL5
12 yellow fever 10.1 IL4 IL5
13 cardiac sarcoidosis 10.1 IFNG IL5
14 esophagitis, eosinophilic, 1 10.1 IL13 IL5
15 eosinophilia-myalgia syndrome 10.1 IFNG IL5
16 pollen allergy 10.1 IL13 IL5
17 african tick-bite fever 10.1 IFNG IL13
18 cough variant asthma 10.1 IL4 IL5
19 egg allergy 10.1 IL4 IL5
20 sulfamethoxazole allergy 10.1 IL4 IL5
21 intrinsic asthma 10.1 IL4 IL5
22 trichinosis 10.1 IL4 IL5
23 non-suppurative otitis media 10.1 IL4 IL5
24 tonsillitis 10.1 IFNG IL4
25 neuritis 10.1 IFNG IL4
26 rasmussen encephalitis 10.1 IFNG IL4
27 kimura disease 10.1 IL4 IL5
28 nonspecific interstitial pneumonia 10.1 IFNG IL13
29 night blindness, congenital stationary, type 1a 10.1 IL13 IL5
30 autoimmune myocarditis 10.0 IFNG IL4
31 b-cell growth factor 10.0 IFNG IL4
32 crustacean allergy 10.0 IFNG IL4
33 allergic bronchopulmonary aspergillosis 10.0 IL4 IL5
34 necatoriasis 10.0 IL10 IL5
35 cow milk allergy 10.0 IL10 IL5
36 strongyloidiasis 10.0 IFNG IL13 IL5
37 ascaris lumbricoides infection 10.0 IFNG IL13 IL5
38 stevens-johnson syndrome/toxic epidermal necrolysis 10.0 IFNG IL13 IL5
39 melioidosis 10.0 IFNG IL10
40 bronchiolitis obliterans 10.0 IFNG IL10
41 dengue hemorrhagic fever 10.0 IFNG IL10
42 extrapulmonary tuberculosis 10.0 IFNG IL10
43 secondary progressive multiple sclerosis 10.0 IFNG IL10
44 ascaridiasis 10.0 IL10 IL13
45 lepromatous leprosy 10.0 IFNG IL10
46 hepatitis a 10.0 IFNG IL10
47 leptospirosis 10.0 IFNG IL10
48 testicular disease 10.0 IFNG IL10
49 tropical spastic paraparesis 10.0 IFNG IL10
50 mixed connective tissue disease 10.0 IFNG IL10

Graphical network of the top 20 diseases related to Nickel Allergic Contact Dermatitis:



Diseases related to Nickel Allergic Contact Dermatitis

Symptoms & Phenotypes for Nickel Allergic Contact Dermatitis

MGI Mouse Phenotypes related to Nickel Allergic Contact Dermatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.92 HADHA IFNG IL10 IL13 IL4 IL5
2 digestive/alimentary MP:0005381 9.8 IFNG IL10 IL13 IL4 IL5
3 embryo MP:0005380 9.77 HADHA IFNG IL10 IL5 NPL
4 immune system MP:0005387 9.73 IFNG IL10 IL13 IL4 IL5 NPL
5 liver/biliary system MP:0005370 9.55 HADHA IFNG IL10 IL4 IL5
6 reproductive system MP:0005389 9.43 IFNG IL10 IL13 IL4 IL5 NPL
7 respiratory system MP:0005388 9.02 IFNG IL10 IL13 IL4 IL5

Drugs & Therapeutics for Nickel Allergic Contact Dermatitis

Drugs for Nickel Allergic Contact Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nickel Phase 2 7440-02-0 934
2 Trace Elements Phase 2
3 Micronutrients Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of the Intradermal Injection of rHuPH20 or Placebo in Subjects With Nickel Allergic Contact Dermatitis Completed NCT00928447 Phase 2 rHuPH20;Placebo

Search NIH Clinical Center for Nickel Allergic Contact Dermatitis

Genetic Tests for Nickel Allergic Contact Dermatitis

Anatomical Context for Nickel Allergic Contact Dermatitis

MalaCards organs/tissues related to Nickel Allergic Contact Dermatitis:

41
Skin, T Cells, Lung, Bone, Heart, Tonsil, B Cells

Publications for Nickel Allergic Contact Dermatitis

Articles related to Nickel Allergic Contact Dermatitis:

# Title Authors Year
1
The Influence of Cultural Norms on Nickel Allergic Contact Dermatitis Prevalence Data. ( 29698359 )
2018
2
Recurrent infections in children with nickel allergic contact dermatitis. ( 22217998 )
2011
3
Genetics of nickel allergic contact dermatitis. ( 17725918 )
2007
4
Impaired responses of peripheral blood mononuclear cells to nickel in patients with nickel-allergic contact dermatitis and concomitant atopic dermatitis. ( 15030331 )
2004
5
Repetitive usage testing with budesonide in experimental nickel--allergic contact dermatitis in individuals hypersensitive to budesonide. ( 11453905 )
2001
6
In vivo nickel allergic contact dermatitis: human model for topical therapeutics. ( 10208508 )
1999
7
An in vitro study of the use of chelating agents in cleaning nickel-contaminated human skin: an alternative approach to preventing nickel allergic contact dermatitis. ( 9817222 )
1998
8
T-cell vaccination in patients with nickel allergic contact dermatitis. ( 7615969 )
1995
9
Hyposensitization in nickel allergic contact dermatitis: clinical and immunologic monitoring. ( 7896945 )
1995

Variations for Nickel Allergic Contact Dermatitis

Expression for Nickel Allergic Contact Dermatitis

Search GEO for disease gene expression data for Nickel Allergic Contact Dermatitis.

Pathways for Nickel Allergic Contact Dermatitis

Pathways related to Nickel Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 IFNG IL10 IL13 IL4 IL5
2
Show member pathways
13.14 IFNG IL10 IL13 IL4 IL5
3
Show member pathways
12.7 IFNG IL10 IL13 IL4 IL5
4 12.64 IFNG IL13 IL4 IL5
5
Show member pathways
12.41 IFNG IL10 IL13 IL4 IL5
6
Show member pathways
12.37 IL13 IL4 IL5
7 12.35 IFNG IL10 IL4
8
Show member pathways
12.29 IFNG IL10 IL4 IL5
9
Show member pathways
12.2 IFNG IL10 IL13 IL4 IL5
10
Show member pathways
12.18 IFNG IL13 IL4 IL5
11
Show member pathways
12.09 IFNG IL10 IL4
12
Show member pathways
12.06 IFNG IL10 IL13 IL4 IL5
13 12.01 HADHA IL10 IL13
14
Show member pathways
11.92 IFNG IL10 IL13 IL4 IL5
15
Show member pathways
11.89 IFNG IL13 IL4
16 11.86 IFNG IL10 IL4 IL5
17 11.84 IL10 IL13 IL4
18
Show member pathways
11.66 IFNG IL4 IL5
19 11.62 IFNG IL13 IL4 IL5
20 11.57 IL10 IL4 IL5
21 11.56 IL13 IL4 IL5
22 11.56 IFNG IL10 IL13 IL4 IL5
23 11.52 IFNG IL10 IL13 IL4
24 11.42 IL10 IL13 IL4
25 11.34 IFNG IL10
26 11.22 IFNG IL4 IL5
27 11.22 IFNG IL10 IL13 IL4 IL5
28 11.19 IFNG IL10
29 11.13 IFNG IL13 IL4 IL5
30 11.09 IFNG IL13
31 11.07 IL10 IL13 IL4 IL5
32 10.83 IL10 IL13 IL4 IL5
33 10.82 IFNG IL10 IL13 IL4 IL5
34 10.44 IFNG IL10 IL13 IL4 IL5

GO Terms for Nickel Allergic Contact Dermatitis

Cellular components related to Nickel Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 IFNG IL10 IL13 IL4 IL5

Biological processes related to Nickel Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.73 IL10 IL13 IL4 IL5
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.63 IFNG IL13 IL4
3 immune response GO:0006955 9.55 IFNG IL10 IL13 IL4 IL5
4 interleukin-12-mediated signaling pathway GO:0035722 9.51 IFNG IL10
5 positive regulation of macrophage activation GO:0043032 9.49 IL10 IL13
6 positive regulation of MHC class II biosynthetic process GO:0045348 9.48 IL10 IL4
7 positive regulation of B cell proliferation GO:0030890 9.43 IL13 IL4 IL5
8 regulation of isotype switching GO:0045191 9.4 IL10 IL4
9 type 2 immune response GO:0042092 9.37 IL10 IL4
10 negative regulation of complement-dependent cytotoxicity GO:1903660 9.32 IL13 IL4
11 negative regulation of endothelial cell apoptotic process GO:2000352 9.13 IL10 IL13 IL4
12 regulation of signaling receptor activity GO:0010469 9.02 IFNG IL10 IL13 IL4 IL5

Molecular functions related to Nickel Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.16 IL13 IL4
2 growth factor activity GO:0008083 9.13 IL10 IL4 IL5
3 cytokine activity GO:0005125 9.02 IFNG IL10 IL13 IL4 IL5

Sources for Nickel Allergic Contact Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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