MCID: NGH001
MIFTS: 50

Night Blindness

Categories: Eye diseases, Metabolic diseases

Aliases & Classifications for Night Blindness

MalaCards integrated aliases for Night Blindness:

Name: Night Blindness 12 77 56 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:8499
ICD9CM 36 368.6 368.60
MeSH 45 D009755
SNOMED-CT 69 65194006 75390007
ICD10 34 H53.6 H53.60
UMLS 74 C0028077

Summaries for Night Blindness

MalaCards based summary : Night Blindness is related to x-linked congenital stationary night blindness and night blindness, congenital stationary, type 2a, and has symptoms including photophobia, amaurosis fugax and metamorphopsia. An important gene associated with Night Blindness is PDE6B (Phosphodiesterase 6B), and among its related pathways/superpathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. The drugs Prednisolone phosphate and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Nyctalopia (/ˌnɪktəˈloʊpiə/ from Greek νύκτ- (nykt-), meaning ''night'', ἀλαός (alaos), meaning... more...

Related Diseases for Night Blindness

Diseases in the Night Blindness family:

Acquired Night Blindness

Diseases related to Night Blindness via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 x-linked congenital stationary night blindness 34.6 CACNA1F NYX
2 night blindness, congenital stationary, type 2a 34.6 CACNA1F NYX
3 night blindness, congenital stationary, type 1a 34.4 NYX RHO
4 night blindness, congenital stationary, type 1e 34.3 CACNA1F GPR179 NYX
5 autosomal dominant congenital stationary night blindness 34.1 GNAT1 PDE6B RHO
6 night blindness, congenital stationary, type 1b 33.9 GPR179 GRM6 LRIT3 NYX TRPM1
7 autosomal recessive congenital stationary night blindness 33.5 GNAT1 GNB3 GRM6 SLC24A1
8 melanoma-associated retinopathy 32.0 RHO SAG TRPM1
9 oguchi disease 31.4 CACNA1F GNAT1 GRK1 GRM6 NYX PDE6B
10 myopia 30.4 CACNA1F NYX RHO
11 fundus albipunctatus 30.4 CACNA1F GNAT1 GRK1 PDE6B RDH5 RHO
12 yemenite deaf-blind hypopigmentation syndrome 30.1 RHO RPE65
13 achromatopsia 30.0 CACNA1F NYX RPE65
14 congenital stationary night blindness 29.9 CABP4 CACNA1F GNAT1 GNB3 GPR179 GRK1
15 aland island eye disease 29.7 CACNA1F NYX RPE65
16 retinitis pigmentosa 29.7 CACNA1F GNAT1 GRK1 NYX PDE6B RDH5
17 retinal degeneration 29.5 PDE6B RHO RPE65 SAG
18 fundus dystrophy 29.0 GRK1 PDE6B RDH5 RHO RPE65
19 night blindness, congenital stationary, autosomal dominant 2 12.7
20 night blindness, congenital stationary, type 1d 12.7
21 night blindness, congenital stationary, type 1f 12.6
22 night blindness, congenital stationary, autosomal dominant 3 12.6
23 night blindness, congenital stationary, autosomal dominant 1 12.6
24 night blindness, congenital stationary, type 1h 12.6
25 night blindness, congenital stationary, type 1c 12.6
26 night blindness, congenital stationary, type 1g 12.6
27 night blindness-skeletal anomalies-dysmorphism syndrome 12.5
28 acquired night blindness 12.4
29 oguchi disease 1 12.2
30 chondroectodermal dysplasia with night blindness 12.2
31 cone-rod synaptic disorder, congenital nonprogressive 12.1
32 oguchi disease 2 12.1
33 keratomalacia 12.0
34 retinal cone dystrophy 3a 11.9
35 retinal cone dystrophy 3b 11.9
36 choroideremia 11.6
37 refsum disease, classic 11.3
38 late-onset retinal degeneration 11.2
39 bietti crystalline corneoretinal dystrophy 11.1
40 gyrate atrophy of choroid and retina 11.1
41 enhanced s-cone syndrome 11.1
42 bothnia retinal dystrophy 11.1
43 cone-rod dystrophy 16 11.1
44 cone-rod dystrophy 2 11.0
45 wagner vitreoretinopathy 11.0
46 retinitis pigmentosa 9 11.0
47 retinitis pigmentosa 10 11.0
48 leber congenital amaurosis 2 11.0
49 jalili syndrome 11.0
50 senior-loken syndrome 1 11.0

Graphical network of the top 20 diseases related to Night Blindness:



Diseases related to Night Blindness

Symptoms & Phenotypes for Night Blindness

UMLS symptoms related to Night Blindness:


photophobia, amaurosis fugax, metamorphopsia, other specified visual disturbances, visual disturbance, subjective visual disturbance, unspecified, visual manifestations

GenomeRNAi Phenotypes related to Night Blindness according to GeneCards Suite gene sharing:

27 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.58 CABP4
2 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.58 RDH5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.58 CABP4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.58 CABP4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.58 CABP4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.58 TRPM1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.58 RDH5
8 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.58 CABP4 RDH5 TRPM1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.58 CABP4
10 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.58 CABP4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.58 TRPM1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.58 RDH5 TRPM1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.58 TRPM1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.58 TRPM1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.58 CABP4

MGI Mouse Phenotypes related to Night Blindness:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.93 CABP4 CACNA1F GNAT1 GNB3 GRK1 GRM6
2 vision/eye MP:0005391 9.53 CABP4 CACNA1F GNAT1 GNB3 GPR179 GRK1
3 pigmentation MP:0001186 9.26 GNAT1 PDE6B RHO RPE65

Drugs & Therapeutics for Night Blindness

Drugs for Night Blindness (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
5
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
6
Racepinephrine Approved Phase 4 329-65-7 838
7
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
8
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
9
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
10 Retinol palmitate Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
12 Hormone Antagonists Phase 4,Phase 2
13 Autonomic Agents Phase 4,Phase 2
14 Anti-Inflammatory Agents Phase 4,Phase 2
15 Peripheral Nervous System Agents Phase 4,Phase 2
16 glucocorticoids Phase 4,Phase 2
17 Gastrointestinal Agents Phase 4,Phase 2
18 retinol Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
19 Antineoplastic Agents, Hormonal Phase 4,Phase 2
20 Antiemetics Phase 4,Phase 2
21 Antioxidants Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
22 Micronutrients Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
23 Hormones Phase 4,Phase 2,Not Applicable
24 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
25 Nutrients Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
26 Trace Elements Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
27 Vitamins Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
28 Prednisolone acetate Phase 4
29 Methylprednisolone Acetate Phase 4
30 Neuroprotective Agents Phase 4
31 Epinephryl borate Phase 4
32 Antiparasitic Agents Phase 4
33 Antimitotic Agents Phase 4
34 Anti-Infective Agents Phase 4,Not Applicable
35 Antiprotozoal Agents Phase 4
36 Anthelmintics Phase 4,Not Applicable
37 Orange Approved Phase 3,Not Applicable
38
Iron Approved, Experimental Phase 2, Phase 3,Phase 3,Early Phase 1,Not Applicable 7439-89-6, 15438-31-0 23925 27284
39
Tocopherol Approved, Investigational Phase 2, Phase 3,Phase 3,Not Applicable 1406-66-2 14986
40
leucovorin Approved Phase 3,Not Applicable 58-05-9 6006 143
41
Ferrous fumarate Approved Phase 3 141-01-5
42
Beta carotene Approved, Nutraceutical Phase 3,Phase 2,Not Applicable 7235-40-7
43
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Not Applicable 59-02-9 14985
44
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Not Applicable 59-30-3 6037
45
Lutein Approved, Investigational, Nutraceutical Phase 2, Phase 3 127-40-2 6433159
46
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3,Not Applicable 1406-16-2
47 Tocotrienol Investigational Phase 2, Phase 3,Phase 3,Not Applicable 6829-55-6
48 Vaccines Phase 2, Phase 3,Not Applicable
49 Provitamins Phase 3,Phase 2,Not Applicable
50 Carotenoids Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 75)
# Name Status NCT ID Phase Drugs
1 Adrenal Cortical Function and Vitamin A Deficiency in Sepsis Completed NCT03152474 Phase 4 Solumedrol 20mg;Vitamin A 100,000 IU
2 Deworming and Enhanced Vitamin A Every 6 Month in Rural Indian Children Aged 1-6 Completed NCT00222547 Phase 4 Vitamin A;Albendazole
3 Efficacy of β-carotene Biofortified Maize in Reducing Vitamin A Deficiency Among Children Completed NCT01695148 Phase 3
4 Efficacy of Biofortified Maize to Improve Maternal and Infant Vitamin A Status Completed NCT02804490 Phase 3
5 Stopping Postpartum Vitamin A Supplementation: Missing Concealed Benefit Completed NCT02043223 Phase 2, Phase 3
6 Impact of Maternal Supplementation With Dual Megadose of Vitamin A Completed NCT00742937 Phase 2, Phase 3
7 Trial of the Impact of Vitamin A on Maternal Mortality Completed NCT00211341 Phase 3
8 Impact of Maternal Vitamin A or Beta-Carotene Supplementation on Maternal and Infant Mortality in Bangladesh Completed NCT00198822 Phase 3
9 Sub-clinical Inflammation and Iron Supplementation Completed NCT01198574 Phase 3
10 Carotenoid Supplementation and Normal Ocular Health Completed NCT02147171 Phase 2, Phase 3
11 Effects of Fat-soluble Vitamins Supplementation on Common Complications and Neural Development in Very Low Birth Weight Infants Recruiting NCT03876704 Phase 3 High dose of fat-Soluble Vitamin;Conventional dose of fat-Soluble Vitamin
12 Community Trial of Newborn Vitamin A Supplementation to Reduce Infant Mortality in Rural Bangladesh Terminated NCT00128557 Phase 3 vitamin A supplementation (50,000 IU)
13 Effect of Vitamin A Supplementation on Immune Responses in Human Neonates Unknown status NCT01476358 Phase 2
14 Intravitreal Dexamethasone Implant in Retinitis Pigmentosa-related Macular Edema- a Retrospective Study Unknown status NCT02804360 Phase 2
15 Vitamin A Absorption From Cassava in Women Completed NCT01381276 Phase 2
16 Vitamin A Equivalence of Plant Carotenoids in Children Completed NCT00680212 Phase 2
17 Vitamin A to Reduce HIV in Vaginal Secretions and Prevent Viral Transmission Completed NCT00053612 Phase 2 Vitamin A
18 Single-dose Postpartum Vitamin A Supplementation of Mothers and Neonates Active, not recruiting NCT00198718 Phase 2 Vitamin A (retinyl palmitate)
19 Gene Therapy for Gyrate Atrophy Completed NCT00001735 Phase 1
20 Evaluation of Safety of Ciliary Neurotrophic Factor Implants in the Eye Completed NCT00063765 Phase 1 Ciliary Neurotrophic Factor Implant NT-501
21 Vitamin A Supplementation in Preterm Infants Unknown status NCT00063596 Not Applicable Vitamin A supplementation
22 The Role of Multivitamins in Pediatric HIV Management in Nigeria Unknown status NCT02552602 Not Applicable
23 Treatment of Congenital Stationary Night Blindness With an Alga Containing High Dose of Beta Carotene Completed NCT00569023 Not Applicable
24 Using Stable Isotope Techniques to Monitor and Assess the Vitamin A Status of Children Susceptible to Infection Completed NCT02363985 Not Applicable
25 Efficacy of Newborn Vitamin A Supplementation in Improving Immune Function Completed NCT01583972 Not Applicable
26 Efficacy of Vitamin A in Fortified Extruded Rice in School Children Completed NCT01199445 Early Phase 1
27 Newborn Vitamin A (VA) Supplementation Pilot Project, Pakistan Completed NCT00674089 Not Applicable
28 Dietary Vitamin A Requirement in Chinese Children and the New Technology of Dietary Assessment Completed NCT01559766
29 Vitamin A, Stool Microbiota and Vaccine Response in Bangladeshi Infants Completed NCT02027610
30 An Efficacy Trial of Iron, Zinc and Vitamin A Fortified Rice in Children in Satun, Thailand Completed NCT01061307 Early Phase 1
31 Retinol Equivalence of Plant Carotenoids in Children Completed NCT00082420
32 Evaluation of a Night Spectacle Correction Concerning an Improvement of Mesopic Vision Quality Completed NCT02965534 Not Applicable
33 Vitamin A Liver Reserves and Serum Markers of Vitamin A in US Adults at Time of Death Completed NCT03305042
34 The Efficacy of Pro-vitamin A Biofortified Cassava on Vitamin A Status in Nigerian Preschool Children Completed NCT02627222 Not Applicable
35 Efficacy of Yellow Cassava to Improve Vitamin A Status of Kenyan School Children Completed NCT01614483 Not Applicable
36 Visual Activity Evoked by Infrared in Humans After Dark Adaptation Completed NCT02909985 Not Applicable
37 Using Stable Isotopes to Assess the Effectiveness of Vitamin A Supplementation in Cameroon Completed NCT03383744 Not Applicable
38 Vitamin A Equivalence of the Provitamin A in Biofortified Bananas Completed NCT02702622 Not Applicable
39 Beta-carotene Absorption and Bioconversion to Vitamin A From Biofortified Cassava Gari Completed NCT02210507 Not Applicable
40 Effect of Daily Consumption of Orange Maize on Breast Milk Retinol in Lactating Zambian Women Completed NCT01922713 Not Applicable
41 Vitamin A Bioavailability in Lactating Women With Marginal Vitamin A Status Completed NCT01420406 Not Applicable
42 Impact of Consumption of Orange-fleshed Sweet Potatoes on the Vitamin A Status of Bangladeshi Women of Reproductive Age Completed NCT00453648 Not Applicable
43 Effect of SNPs in the BCMO1 Enzyme Completed NCT02276014 Not Applicable
44 Nutritional Outcomes After Vitamin A Supplementation in Subjects With SCD Completed NCT03632876 Not Applicable
45 Assessing Model Parameters for Applying the Retinol Isotope Dilution (RID) Method Completed NCT02996513 Not Applicable
46 A Study on Immunological Effect of Vitamin A and Zinc in a Placebo Controlled 4 Cell Trial Completed NCT00374023 Not Applicable Zinc, or Vitamin A or both
47 Making Maternal Post-partum Vitamin A Supplementation Effective: The Role of Timing and Inflammation Completed NCT00952640 Not Applicable
48 Vitamin A and Maternal-infant Flu Vaccine Response Completed NCT00817661 Not Applicable
49 Oral Vitamin A Supplementation in Neonates With Birth Weight < 1500 g Completed NCT02102711 Not Applicable
50 High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM Completed NCT00388921 Not Applicable Vitamin A

Search NIH Clinical Center for Night Blindness

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: night blindness

Genetic Tests for Night Blindness

Anatomical Context for Night Blindness

MalaCards organs/tissues related to Night Blindness:

42
Eye, Liver, Testes, Bone, Breast, Retina, Pancreas

Publications for Night Blindness

Articles related to Night Blindness:

(show top 50) (show all 434)
# Title Authors Year
1
Molecular interactions and mutational impact upon rhodopsin (G90→D90) for hindering dark adaptation of eye: A comparative structural level outlook for signaling mechanism in night blindness. ( 30659944 )
2019
2
Presentation of TRPM1-Associated Congenital Stationary Night Blindness in Children. ( 29522070 )
2018
3
Revisiting Congenital Stationary Night Blindness in the Molecular Era. ( 29522064 )
2018
4
A Novel Heterozygous Missense Mutation in <i>GNAT1</i> Leads to Autosomal Dominant Riggs Type of Congenital Stationary Night Blindness. ( 29850563 )
2018
5
Cone dystrophy and ectopic synaptogenesis in a Cacna1f loss of function model of congenital stationary night blindness (CSNB2A). ( 29179637 )
2018
6
Neuronal intranuclear hyaline inclusion disease presenting with childhood-onset night blindness associated with progressive retinal dystrophy. ( 29627037 )
2018
7
Unusual manifestation of vitamin A deficiency presenting with generalized xerosis without night blindness. ( 29744078 )
2018
8
Riggs-type dominant congenital stationary night blindness: ERG findings, a new GNAT1 mutation and a systemic association. ( 30051303 )
2018
9
Congenital stationary night blindness associated with morning glory disc malformation: a novel hemizygous mutation in CACNA1F. ( 30067413 )
2018
10
Macular sensitivity in patients with congenital stationary night-blindness. ( 30573500 )
2018
11
Congenital Stationary Night Blindness. ( 30578486 )
2018
12
Night Blindness, Bitot's Spot & Vitamin A Deficiency. ( 30265370 )
2018
13
Night Blindness, Ring Scotoma, and a Nonrecordable Electroretinogram in an Elderly Woman. ( 30452517 )
2018
14
Long-Term Clinical Course in a Patient with Complete Congenital Stationary Night Blindness. ( 28512427 )
2017
15
Novel TRPM1 mutations in two Chinese families with early-onset high myopia, with or without complete congenital stationary night blindness. ( 27803854 )
2016
16
Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics. ( 27267879 )
2016
17
Redundant contribution of a Transient Receptor Potential cation channel Member 1 exon 11 single nucleotide polymorphism to equine congenital stationary night blindness. ( 27329127 )
2016
18
Congenital stationary night blindness with hypoplastic discs, negative electroretinogram and thinning of the inner nuclear layer. ( 27084085 )
2016
19
Next-generation sequencing confirms the implication of SLC24A1 in autosomal-recessive congenital stationary night blindness. ( 26822852 )
2016
20
Biallelic Mutations in GNB3 Cause a Unique Form of Autosomal-Recessive Congenital Stationary Night Blindness. ( 27063057 )
2016
21
Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin Mutation. ( 26427453 )
2016
22
Clinical Characteristics, Mutation Spectrum, and Prevalence of A8land Eye Disease/Incomplete Congenital Stationary Night Blindness in Denmark. ( 28002560 )
2016
23
Structural role of the T94I rhodopsin mutation in congenital stationary night blindness. ( 27458239 )
2016
24
Psychophysical measures of visual function and everyday perceptual experience in a case of congenital stationary night blindness. ( 27601873 )
2016
25
Mutation screening of the LRIT3, CABP4, and GPR179 genes in Chinese patients with Schubert-Bornschein congenital stationary night blindness. ( 27428514 )
2016
26
Mutations in GRM6 identified in consanguineous Pakistani families with congenital stationary night blindness. ( 26628857 )
2015
27
Isotretinoin-Induced Night Blindness. ( 26288455 )
2015
28
Twenty-five thousand years of fluctuating selection on leopard complex spotting and congenital night blindness in horses. ( 25487337 )
2015
29
Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness. ( 26310623 )
2015
30
A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness. ( 26368928 )
2015
31
Identification of a new mutant allele, Grm6(nob7), for complete congenital stationary night blindness. ( 26241901 )
2015
32
Determinants of gestational night blindness in pregnant women from Rio de Janeiro, Brazil. ( 26055085 )
2015
33
A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. ( 26246500 )
2015
34
Night blindness due to vitamin A deficiency associated with resected adenocarcinoma of the pancreas. ( 25709934 )
2015
35
Assessment of selenium and mercury in biological samples of normal and night blindness children of age groups (3-7) and (8-12) years. ( 25655123 )
2015
36
Recurrent episodes of night blindness in a patient with short bowel syndrome. ( 26507840 )
2015
37
Cacna1f gene decreased contractility of skeletal muscle in rat model with congenital stationary night blindness. ( 25748727 )
2015
38
Acquired night blindness due to bad eating patterns. ( 25804276 )
2015
39
Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness. ( 26234941 )
2015
40
Night blindness and Crohn's disease. ( 24715231 )
2014
41
Isotretinoin and night blindness. ( 25117163 )
2014
42
Seasonal variation in night blindness incidence among Union soldiers in the US Civil War. ( 25200714 )
2014
43
A truncated form of rod photoreceptor PDE6 I^-subunit causes autosomal dominant congenital stationary night blindness by interfering with the inhibitory activity of the I^-subunit. ( 24760071 )
2014
44
Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2. ( 24796500 )
2014
45
Prevalence of night blindness in Bashagard district in Hormozgan, Iran, in 2011. ( 25763164 )
2014
46
Sorting out Co-occurrence of Rare Monogenic Retinopathies: Stargardt Disease Co-existing with Congenital Stationary Night Blindness. ( 24397708 )
2014
47
Night blindness due to vitamin A deficiency associated with copper deficiency myelopathy secondary to bowel bypass surgery. ( 24781845 )
2014
48
Lrit3 deficient mouse (nob6): a novel model of complete congenital stationary night blindness (cCSNB). ( 24598786 )
2014
49
The role of prenatal nutrition assistance on the prevalence of night blindness in pregnant adults. ( 24951995 )
2014
50
Night blindness and ancient remedy. ( 25774260 )
2014

Variations for Night Blindness

Copy number variations for Night Blindness from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 175785 3 44200000 50600000 Gain or loss GNAT1 Night blindness

Expression for Night Blindness

Search GEO for disease gene expression data for Night Blindness.

Pathways for Night Blindness

GO Terms for Night Blindness

Cellular components related to Night Blindness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.85 GNAT1 GRM6 LRIT3 RHO SAG
2 cell body GO:0044297 9.5 GNB3 RDH5 RPE65
3 photoreceptor inner segment GO:0001917 9.43 GNAT1 RHO SAG
4 photoreceptor outer segment membrane GO:0042622 9.37 GNAT1 RHO
5 photoreceptor outer segment GO:0001750 9.26 CACNA1F GNAT1 RHO SAG
6 new growing cell tip GO:0035841 9.16 GRM6 TRPM1
7 photoreceptor disc membrane GO:0097381 8.92 GNAT1 GRK1 PDE6B RHO
8 membrane GO:0016020 10.22 CACNA1F GNAT1 GPR179 GRK1 GRM6 LRIT3
9 plasma membrane GO:0005886 10.13 CACNA1F GNAT1 GNB3 GPR179 GRM6 PDE6B

Biological processes related to Night Blindness according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.8 CABP4 CACNA1F GNAT1 GPR179 GRK1 GRM6
2 retina development in camera-type eye GO:0060041 9.77 GNAT1 GRM6 PDE6B RHO RPE65
3 calcium ion transmembrane transport GO:0070588 9.76 CACNA1F SLC24A1 TRPM1
4 retinoid metabolic process GO:0001523 9.69 RDH5 RHO RPE65
5 phototransduction GO:0007602 9.65 CABP4 GNAT1 RHO
6 regulation of rhodopsin mediated signaling pathway GO:0022400 9.65 GNAT1 GRK1 PDE6B RHO SAG
7 response to light stimulus GO:0009416 9.63 GNAT1 RHO RPE65
8 detection of light stimulus involved in visual perception GO:0050908 9.62 CACNA1F GNAT1 GRM6 RPE65
9 retinol metabolic process GO:0042572 9.59 RDH5 RPE65
10 phototransduction, visible light GO:0007603 9.58 GNAT1 PDE6B RHO
11 cellular response to light stimulus GO:0071482 9.57 RHO TRPM1
12 G protein-coupled glutamate receptor signaling pathway GO:0007216 9.56 GRM6 TRPM1
13 cellular response to electrical stimulus GO:0071257 9.55 GNAT1 RPE65
14 rhodopsin mediated signaling pathway GO:0016056 9.55 GNAT1 GRK1 PDE6B RHO SAG
15 sensory perception of light stimulus GO:0050953 9.54 GRM6 RHO
16 response to light intensity GO:0009642 9.52 GNAT1 SLC24A1
17 detection of light stimulus GO:0009583 9.49 PDE6B RHO
18 response to stimulus GO:0050896 9.4 CACNA1F GNAT1 GRK1 GRM6 LRIT3 NYX
19 signal transduction GO:0007165 10.09 CABP4 GNAT1 GNB3 GRK1 GRM6 PDE6B
20 G protein-coupled receptor signaling pathway GO:0007186 10.05 GNAT1 GNB3 GPR179 GRM6 PDE6B RHO

Molecular functions related to Night Blindness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium channel activity GO:0005262 8.8 CACNA1F SLC24A1 TRPM1

Sources for Night Blindness

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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