MCID: NGH001
MIFTS: 51

Night Blindness

Categories: Eye diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Night Blindness

MalaCards integrated aliases for Night Blindness:

Name: Night Blindness 12 76 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8499
ICD10 33 H53.6 H53.60
ICD9CM 35 368.6 368.60
MeSH 44 D009755
UMLS 73 C0028077

Summaries for Night Blindness

MalaCards based summary : Night Blindness is related to x-linked congenital stationary night blindness and night blindness, congenital stationary, type 2a, and has symptoms including other specified visual disturbances, photophobia and amaurosis fugax. An important gene associated with Night Blindness is PDE6B (Phosphodiesterase 6B), and among its related pathways/superpathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. The drugs Albendazole and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and testes, and related phenotypes are nervous system and vision/eye

Wikipedia : 76 Nyctalopia (/ˌnɪktəˈloʊpiə/ from Greek νύκτ- (nykt-), meaning \'night\', ἀλαός (alaos), meaning \'blind,... more...

Related Diseases for Night Blindness

Diseases in the Night Blindness family:

Acquired Night Blindness Hereditary Night Blindness

Diseases related to Night Blindness via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 x-linked congenital stationary night blindness 34.8 CACNA1F NYX
2 night blindness, congenital stationary, type 2a 34.8 CACNA1F NYX
3 night blindness, congenital stationary, type 1a 34.5 NYX RHO
4 night blindness, congenital stationary, type 1e 34.3 CACNA1F GPR179 NYX
5 autosomal dominant congenital stationary night blindness 34.2 GNAT1 PDE6B RHO
6 night blindness, congenital stationary, type 1b 33.3 GPR179 GRM6 LRIT3 NYX TRPM1
7 autosomal recessive congenital stationary night blindness 32.8 GNAT1 GNB3 GRM6 SLC24A1
8 melanoma-associated retinopathy 31.9 RHO SAG TRPM1
9 cone-rod dystrophy 2 31.1 CACNA1F RHO RPE65
10 hereditary night blindness 30.6 CACNA1F GRK1 GRM6 NYX RDH5 RHO
11 aland island eye disease 29.6 CACNA1F NYX RPE65
12 myopia 29.4 CACNA1F GNAT1 GRM6 NYX RHO
13 retinal degeneration 29.0 PDE6B RHO RPE65 SAG
14 fundus albipunctatus 28.1 CACNA1F GNAT1 GRK1 PDE6B RDH5 RHO
15 fundus dystrophy 27.7 GRK1 PDE6B RDH5 RHO RPE65
16 retinitis pigmentosa 27.4 CACNA1F GNAT1 GRK1 NYX PDE6B RDH5
17 congenital stationary night blindness 25.1 CABP4 CACNA1F GNAT1 GNB3 GPR179 GRK1
18 night blindness, congenital stationary, type 1d 12.5
19 night blindness, congenital stationary, type 1f 12.5
20 night blindness, congenital stationary, autosomal dominant 2 12.5
21 night blindness, congenital stationary, autosomal dominant 3 12.5
22 night blindness, congenital stationary, autosomal dominant 1 12.5
23 night blindness, congenital stationary, type 1h 12.5
24 night blindness, congenital stationary, type 1c 12.4
25 night blindness, congenital stationary, type 1g 12.4
26 night blindness-skeletal anomalies-dysmorphism syndrome 12.3
27 acquired night blindness 12.2
28 oguchi disease 1 12.1
29 chondroectodermal dysplasia with night blindness 12.0
30 cone-rod synaptic disorder, congenital nonprogressive 11.9
31 oguchi disease 2 11.9
32 keratomalacia 11.8
33 retinal cone dystrophy 3a 11.7
34 retinal cone dystrophy 3b 11.7
35 choroideremia 11.4
36 refsum disease, classic 11.1
37 late-onset retinal degeneration 11.1
38 bietti crystalline corneoretinal dystrophy 11.0
39 gyrate atrophy of choroid and retina 11.0
40 enhanced s-cone syndrome 11.0
41 cone-rod dystrophy 16 11.0
42 wagner vitreoretinopathy 10.8
43 retinitis pigmentosa 9 10.8
44 leber congenital amaurosis 2 10.8
45 jalili syndrome 10.8
46 senior-loken syndrome 1 10.8
47 retinitis pigmentosa 3 10.8
48 nystagmus 1, congenital, x-linked 10.8
49 retinitis pigmentosa 2 10.8
50 birdshot chorioretinopathy 10.8

Graphical network of the top 20 diseases related to Night Blindness:



Diseases related to Night Blindness

Symptoms & Phenotypes for Night Blindness

UMLS symptoms related to Night Blindness:


other specified visual disturbances, photophobia, amaurosis fugax, subjective visual disturbance, unspecified, metamorphopsia, visual disturbance, visual manifestations

MGI Mouse Phenotypes related to Night Blindness:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.93 CABP4 CACNA1F GNAT1 GNB3 GRK1 GRM6
2 vision/eye MP:0005391 9.53 CABP4 CACNA1F GNAT1 GNB3 GPR179 GRK1
3 pigmentation MP:0001186 9.26 GNAT1 PDE6B RHO RPE65

Drugs & Therapeutics for Night Blindness

Drugs for Night Blindness (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
5
Racepinephrine Approved Phase 4 329-65-7 838
6
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 11103-57-4, 68-26-8 445354
7 glucocorticoids Phase 4,Phase 2
8 Retinol palmitate Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
9 Micronutrients Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
10 Gastrointestinal Agents Phase 4,Phase 2
11 Hormone Antagonists Phase 4,Phase 2
12 Trace Elements Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
13 Hormones Phase 4,Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
15 Peripheral Nervous System Agents Phase 4,Phase 2
16 Vitamins Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
17 Antiemetics Phase 4,Phase 2
18 Antioxidants Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
19 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
20 Anti-Inflammatory Agents Phase 4,Phase 2
21 Autonomic Agents Phase 4,Phase 2
22 Antineoplastic Agents, Hormonal Phase 4,Phase 2
23 Prednisolone acetate Phase 4
24 Methylprednisolone acetate Phase 4
25 Methylprednisolone Hemisuccinate Phase 4
26 Neuroprotective Agents Phase 4
27 Anthelmintics Phase 4
28 Epinephryl borate Phase 4
29 Prednisolone hemisuccinate Phase 4
30 Prednisolone phosphate Phase 4
31 Anti-Infective Agents Phase 4
32 Antiparasitic Agents Phase 4
33 Antiprotozoal Agents Phase 4
34 Antimitotic Agents Phase 4
35 retinol Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
36
Iron Approved Phase 2, Phase 3,Phase 3,Early Phase 1,Not Applicable 7439-89-6 23925
37
Lutein Approved, Investigational, Nutraceutical Phase 2, Phase 3 127-40-2 6433159
38
leucovorin Approved, Nutraceutical Phase 3,Not Applicable 58-05-9 143 6006
39
Tocopherol Approved, Investigational, Nutraceutical Phase 2, Phase 3,Not Applicable 1406-66-2 14986
40
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Not Applicable 59-30-3 6037
41
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Not Applicable 59-02-9 14985
42
Beta carotene Approved, Nutraceutical Phase 3,Phase 2,Not Applicable 7235-40-7
43 Orange Approved, Nutraceutical Phase 3,Not Applicable
44 Vaccines Phase 2, Phase 3,Not Applicable
45 Ferrous fumarate Phase 3
46 Hematinics Phase 3,Not Applicable
47 Tin Fluorides Phase 2, Phase 3
48 Tocopherols Phase 2, Phase 3,Not Applicable
49 Tocotrienols Phase 2, Phase 3,Not Applicable
50 Vitamin B Complex Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 70)
# Name Status NCT ID Phase Drugs
1 Adrenal Cortical Function and Vitamin A Deficiency in Sepsis Completed NCT03152474 Phase 4 Solumedrol 20mg;Vitamin A 100,000 IU
2 Deworming and Enhanced Vitamin A Every 6 Month in Rural Indian Children Aged 1-6 Completed NCT00222547 Phase 4 Vitamin A;Albendazole
3 Efficacy of β-carotene Biofortified Maize in Reducing Vitamin A Deficiency Among Children Completed NCT01695148 Phase 3
4 Efficacy of Biofortified Maize to Improve Maternal and Infant Vitamin A Status Completed NCT02804490 Phase 3
5 Stopping Postpartum Vitamin A Supplementation: Missing Concealed Benefit Completed NCT02043223 Phase 2, Phase 3
6 Impact of Maternal Supplementation With Dual Megadose of Vitamin A Completed NCT00742937 Phase 2, Phase 3
7 Trial of the Impact of Vitamin A on Maternal Mortality Completed NCT00211341 Phase 3
8 Impact of Maternal Vitamin A or Beta-Carotene Supplementation on Maternal and Infant Mortality in Bangladesh Completed NCT00198822 Phase 3
9 Sub-clinical Inflammation and Iron Supplementation Completed NCT01198574 Phase 3
10 Carotenoid Supplementation and Normal Ocular Health Completed NCT02147171 Phase 2, Phase 3
11 Community Trial of Newborn Vitamin A Supplementation to Reduce Infant Mortality in Rural Bangladesh Terminated NCT00128557 Phase 3 vitamin A supplementation (50,000 IU)
12 Effect of Vitamin A Supplementation on Immune Responses in Human Neonates Unknown status NCT01476358 Phase 2
13 Intravitreal Dexamethasone Implant in Retinitis Pigmentosa-related Macular Edema- a Retrospective Study Unknown status NCT02804360 Phase 2
14 Vitamin A Absorption From Cassava in Women Completed NCT01381276 Phase 2
15 Vitamin A Equivalence of Plant Carotenoids in Children Completed NCT00680212 Phase 2
16 Vitamin A to Reduce HIV in Vaginal Secretions and Prevent Viral Transmission Completed NCT00053612 Phase 2 Vitamin A
17 Single-dose Postpartum Vitamin A Supplementation of Mothers and Neonates Active, not recruiting NCT00198718 Phase 2 Vitamin A (retinyl palmitate)
18 Gene Therapy for Gyrate Atrophy Completed NCT00001735 Phase 1
19 Evaluation of Safety of Ciliary Neurotrophic Factor Implants in the Eye Completed NCT00063765 Phase 1 Ciliary Neurotrophic Factor Implant NT-501
20 Vitamin A Supplementation in Preterm Infants Unknown status NCT00063596 Not Applicable Vitamin A supplementation
21 Nutributter Programming to Prevent Undernutrition: an Evaluation Unknown status NCT01552512 Not Applicable
22 The Role of Multivitamins in Pediatric HIV Management in Nigeria Unknown status NCT02552602 Not Applicable
23 Treatment of Congenital Stationary Night Blindness With an Alga Containing High Dose of Beta Carotene Completed NCT00569023 Not Applicable
24 Using Stable Isotope Techniques to Monitor and Assess the Vitamin A Status of Children Susceptible to Infection Completed NCT02363985 Not Applicable
25 Efficacy of Newborn Vitamin A Supplementation in Improving Immune Function Completed NCT01583972 Not Applicable
26 Efficacy of Vitamin A in Fortified Extruded Rice in School Children Completed NCT01199445 Early Phase 1
27 Newborn Vitamin A (VA) Supplementation Pilot Project, Pakistan Completed NCT00674089 Not Applicable
28 Dietary Vitamin A Requirement in Chinese Children and the New Technology of Dietary Assessment Completed NCT01559766
29 Vitamin A, Stool Microbiota and Vaccine Response in Bangladeshi Infants Completed NCT02027610
30 An Efficacy Trial of Iron, Zinc and Vitamin A Fortified Rice in Children in Satun, Thailand Completed NCT01061307 Early Phase 1
31 Retinol Equivalence of Plant Carotenoids in Children Completed NCT00082420
32 Evaluation of a Night Spectacle Correction Concerning an Improvement of Mesopic Vision Quality Completed NCT02965534 Not Applicable
33 Vitamin A Liver Reserves and Serum Markers of Vitamin A in US Adults at Time of Death Completed NCT03305042
34 The Efficacy of Pro-vitamin A Biofortified Cassava on Vitamin A Status in Nigerian Preschool Children Completed NCT02627222 Not Applicable
35 Efficacy of Yellow Cassava to Improve Vitamin A Status of Kenyan School Children Completed NCT01614483 Not Applicable
36 Visual Activity Evoked by Infrared in Humans After Dark Adaptation Completed NCT02909985 Not Applicable
37 Using Stable Isotopes to Assess the Effectiveness of Vitamin A Supplementation in Cameroon Completed NCT03383744 Not Applicable
38 Vitamin A Equivalence of the Provitamin A in Biofortified Bananas Completed NCT02702622 Not Applicable
39 Beta-carotene Absorption and Bioconversion to Vitamin A From Biofortified Cassava Gari Completed NCT02210507 Not Applicable
40 Effect of Daily Consumption of Orange Maize on Breast Milk Retinol in Lactating Zambian Women Completed NCT01922713 Not Applicable
41 Vitamin A Bioavailability in Lactating Women With Marginal Vitamin A Status Completed NCT01420406 Not Applicable
42 Impact of Consumption of Orange-fleshed Sweet Potatoes on the Vitamin A Status of Bangladeshi Women of Reproductive Age Completed NCT00453648 Not Applicable
43 Effect of SNPs in the BCMO1 Enzyme Completed NCT02276014 Not Applicable
44 Assessing Model Parameters for Applying the Retinol Isotope Dilution (RID) Method Completed NCT02996513 Not Applicable
45 A Study on Immunological Effect of Vitamin A and Zinc in a Placebo Controlled 4 Cell Trial Completed NCT00374023 Not Applicable Zinc, or Vitamin A or both
46 Making Maternal Post-partum Vitamin A Supplementation Effective: The Role of Timing and Inflammation Completed NCT00952640 Not Applicable
47 Vitamin A and Maternal-infant Flu Vaccine Response Completed NCT00817661 Not Applicable
48 Oral Vitamin A Supplementation in Neonates With Birth Weight < 1500 g Completed NCT02102711 Not Applicable
49 High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM Completed NCT00388921 Not Applicable Vitamin A
50 Identification of New Biomarkers of Banana and Tomato Intake Completed NCT03581955 Not Applicable

Search NIH Clinical Center for Night Blindness

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: night blindness

Genetic Tests for Night Blindness

Anatomical Context for Night Blindness

MalaCards organs/tissues related to Night Blindness:

41
Eye, Liver, Testes, Bone, Retina, Pancreas, Skin

Publications for Night Blindness

Articles related to Night Blindness:

(show top 50) (show all 406)
# Title Authors Year
1
Presentation of TRPM1-Associated Congenital Stationary Night Blindness in Children. ( 29522070 )
2018
2
Revisiting Congenital Stationary Night Blindness in the Molecular Era. ( 29522064 )
2018
3
A Novel Heterozygous Missense Mutation in <i>GNAT1</i> Leads to Autosomal Dominant Riggs Type of Congenital Stationary Night Blindness. ( 29850563 )
2018
4
Cone dystrophy and ectopic synaptogenesis in a Cacna1f loss of function model of congenital stationary night blindness (CSNB2A). ( 29179637 )
2018
5
Neuronal intranuclear hyaline inclusion disease presenting with childhood-onset night blindness associated with progressive retinal dystrophy. ( 29627037 )
2018
6
Unusual manifestation of vitamin A deficiency presenting with generalized xerosis without night blindness. ( 29744078 )
2018
7
Long-Term Clinical Course in a Patient with Complete Congenital Stationary Night Blindness. ( 28512427 )
2017
8
Novel TRPM1 mutations in two Chinese families with early-onset high myopia, with or without complete congenital stationary night blindness. ( 27803854 )
2016
9
Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics. ( 27267879 )
2016
10
Redundant contribution of a Transient Receptor Potential cation channel Member 1 exon 11 single nucleotide polymorphism to equine congenital stationary night blindness. ( 27329127 )
2016
11
Congenital stationary night blindness with hypoplastic discs, negative electroretinogram and thinning of the inner nuclear layer. ( 27084085 )
2016
12
Next-generation sequencing confirms the implication of SLC24A1 in autosomal-recessive congenital stationary night blindness. ( 26822852 )
2016
13
Biallelic Mutations in GNB3 Cause a Unique Form of Autosomal-Recessive Congenital Stationary Night Blindness. ( 27063057 )
2016
14
Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin Mutation. ( 26427453 )
2016
15
Clinical Characteristics, Mutation Spectrum, and Prevalence of A8land Eye Disease/Incomplete Congenital Stationary Night Blindness in Denmark. ( 28002560 )
2016
16
Structural role of the T94I rhodopsin mutation in congenital stationary night blindness. ( 27458239 )
2016
17
Psychophysical measures of visual function and everyday perceptual experience in a case of congenital stationary night blindness. ( 27601873 )
2016
18
Mutation screening of the LRIT3, CABP4, and GPR179 genes in Chinese patients with Schubert-Bornschein congenital stationary night blindness. ( 27428514 )
2016
19
Mutations in GRM6 identified in consanguineous Pakistani families with congenital stationary night blindness. ( 26628857 )
2015
20
Isotretinoin-Induced Night Blindness. ( 26288455 )
2015
21
Twenty-five thousand years of fluctuating selection on leopard complex spotting and congenital night blindness in horses. ( 25487337 )
2015
22
Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness. ( 26310623 )
2015
23
A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness. ( 26368928 )
2015
24
Identification of a new mutant allele, Grm6(nob7), for complete congenital stationary night blindness. ( 26241901 )
2015
25
Determinants of gestational night blindness in pregnant women from Rio de Janeiro, Brazil. ( 26055085 )
2015
26
A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. ( 26246500 )
2015
27
Night blindness due to vitamin A deficiency associated with resected adenocarcinoma of the pancreas. ( 25709934 )
2015
28
Assessment of selenium and mercury in biological samples of normal and night blindness children of age groups (3-7) and (8-12) years. ( 25655123 )
2015
29
Recurrent episodes of night blindness in a patient with short bowel syndrome. ( 26507840 )
2015
30
Cacna1f gene decreased contractility of skeletal muscle in rat model with congenital stationary night blindness. ( 25748727 )
2015
31
Acquired night blindness due to bad eating patterns. ( 25804276 )
2015
32
Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness. ( 26234941 )
2015
33
Night blindness and Crohn's disease. ( 24715231 )
2014
34
Isotretinoin and night blindness. ( 25117163 )
2014
35
Seasonal variation in night blindness incidence among Union soldiers in the US Civil War. ( 25200714 )
2014
36
A truncated form of rod photoreceptor PDE6 I^-subunit causes autosomal dominant congenital stationary night blindness by interfering with the inhibitory activity of the I^-subunit. ( 24760071 )
2014
37
Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2. ( 24796500 )
2014
38
Prevalence of night blindness in Bashagard district in Hormozgan, Iran, in 2011. ( 25763164 )
2014
39
Sorting out Co-occurrence of Rare Monogenic Retinopathies: Stargardt Disease Co-existing with Congenital Stationary Night Blindness. ( 24397708 )
2014
40
Night blindness due to vitamin A deficiency associated with copper deficiency myelopathy secondary to bowel bypass surgery. ( 24781845 )
2014
41
Lrit3 deficient mouse (nob6): a novel model of complete congenital stationary night blindness (cCSNB). ( 24598786 )
2014
42
The role of prenatal nutrition assistance on the prevalence of night blindness in pregnant adults. ( 24951995 )
2014
43
Night blindness and ancient remedy. ( 25774260 )
2014
44
Photoreceptor degeneration in two mouse models for congenital stationary night blindness type 2. ( 24466230 )
2014
45
Molecular profiling of complete congenital stationary night blindness: a pilot study on an Indian cohort. ( 24715752 )
2014
46
Congenital stationary night blindness: An analysis and update of genotype-phenotype correlations and pathogenic mechanisms. ( 25307992 )
2014
47
Dysregulation of Cav 1.4 channels disrupts the maturation of photoreceptor synaptic ribbons in congenital stationary night blindness type 2. ( 24064553 )
2013
48
Xerophthalmia and acquired night blindness in a patient with a history of gastrointestinal neoplasia and normal serum vitamin A levels. ( 23334438 )
2013
49
Insights into congenital stationary night blindness based on the structure of G90D rhodopsin. ( 23579341 )
2013
50
Arrayed primer extension microarray for the analysis of genes associated with congenital stationary night blindness. ( 23296619 )
2013

Variations for Night Blindness

Copy number variations for Night Blindness from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 175785 3 44200000 50600000 Gain or loss GNAT1 Night blindness

Expression for Night Blindness

Search GEO for disease gene expression data for Night Blindness.

Pathways for Night Blindness

GO Terms for Night Blindness

Cellular components related to Night Blindness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.83 GNAT1 GRM6 LRIT3 RHO SAG
2 cell body GO:0044297 9.5 GNB3 RDH5 RPE65
3 photoreceptor inner segment GO:0001917 9.43 GNAT1 RHO SAG
4 photoreceptor outer segment membrane GO:0042622 9.37 GNAT1 RHO
5 photoreceptor outer segment GO:0001750 9.26 CACNA1F GNAT1 RHO SAG
6 new growing cell tip GO:0035841 9.16 GRM6 TRPM1
7 photoreceptor disc membrane GO:0097381 8.92 GNAT1 GRK1 PDE6B RHO
8 membrane GO:0016020 10.22 CACNA1F GNAT1 GPR179 GRK1 GRM6 LRIT3
9 plasma membrane GO:0005886 10.16 CACNA1F GNAT1 GNB3 GPR179 GRM6 PDE6B

Biological processes related to Night Blindness according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.8 CABP4 CACNA1F GNAT1 GPR179 GRK1 GRM6
2 retina development in camera-type eye GO:0060041 9.77 GNAT1 GRM6 PDE6B RHO RPE65
3 calcium ion transmembrane transport GO:0070588 9.75 CACNA1F SLC24A1 TRPM1
4 retinoid metabolic process GO:0001523 9.69 RDH5 RHO RPE65
5 regulation of rhodopsin mediated signaling pathway GO:0022400 9.65 GNAT1 GRK1 PDE6B RHO SAG
6 phototransduction GO:0007602 9.63 CABP4 GNAT1 RHO
7 detection of light stimulus involved in visual perception GO:0050908 9.62 CACNA1F GNAT1 GRM6 RPE65
8 response to light stimulus GO:0009416 9.61 GNAT1 RHO RPE65
9 retinol metabolic process GO:0042572 9.58 RDH5 RPE65
10 phototransduction, visible light GO:0007603 9.58 GNAT1 PDE6B RHO
11 G-protein coupled glutamate receptor signaling pathway GO:0007216 9.57 GRM6 TRPM1
12 cellular response to light stimulus GO:0071482 9.56 RHO TRPM1
13 cellular response to electrical stimulus GO:0071257 9.55 GNAT1 RPE65
14 rhodopsin mediated signaling pathway GO:0016056 9.55 GNAT1 GRK1 PDE6B RHO SAG
15 sensory perception of light stimulus GO:0050953 9.54 GRM6 RHO
16 response to light intensity GO:0009642 9.52 GNAT1 SLC24A1
17 detection of light stimulus GO:0009583 9.49 PDE6B RHO
18 response to stimulus GO:0050896 9.4 CACNA1F GNAT1 GRK1 GRM6 LRIT3 NYX
19 signal transduction GO:0007165 10.13 CABP4 GNAT1 GNB3 GRK1 GRM6 PDE6B

Molecular functions related to Night Blindness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 obsolete signal transducer activity GO:0004871 9.26 GNAT1 GNB3 GRM6 RHO
2 calcium channel activity GO:0005262 8.8 CACNA1F SLC24A1 TRPM1

Sources for Night Blindness

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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