MCID: NPP008
MIFTS: 20

Nipple Benign Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Nipple Benign Neoplasm

MalaCards integrated aliases for Nipple Benign Neoplasm:

Name: Nipple Benign Neoplasm 12
Tumor of Nipple 12
Nipple Neoplasm 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3003
NCIt 49 C5212
UMLS 71 C1112166

Summaries for Nipple Benign Neoplasm

Disease Ontology : 12 A breast benign neoplasm that is located in the nipple.

MalaCards based summary : Nipple Benign Neoplasm, also known as tumor of nipple, is related to laryngeal small cell carcinoma and lung leiomyosarcoma. An important gene associated with Nipple Benign Neoplasm is CNN1 (Calponin 1), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. Affiliated tissues include nipple and breast, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Nipple Benign Neoplasm

Diseases related to Nipple Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 laryngeal small cell carcinoma 10.2 KRT5 CNN1
2 lung leiomyosarcoma 10.2 KRT5 CALD1
3 colon leiomyosarcoma 10.2 KRT5 CALD1
4 perivascular epithelioid cell tumor 10.2 MME CALD1
5 testicular fibroma 10.2 KRT5 CALD1
6 mixed endometrial stromal and smooth muscle tumor 10.2 MME CALD1
7 smooth muscle tumor 10.2 MME CALD1
8 vaginal endometrial stromal tumor 10.2 MME CALD1
9 endometrial stromal tumor 10.2 MME CALD1
10 fallopian tube leiomyoma 10.2 MME CALD1
11 urethra leiomyoma 10.2 MME CALD1
12 fallopian tube benign neoplasm 10.2 MME CALD1
13 breast myofibroblastoma 10.2 MME CALD1
14 paranasal sinus lymphoma 10.2 MME CNN1
15 lung combined type small cell carcinoma 10.2 MME CALD1
16 cervical mucinous adenocarcinoma 10.2 KRT7 CALD1
17 nephrogenic adenofibroma 10.2 KRT7 CALD1
18 esophagus sarcoma 10.2 KRT5 CALD1
19 intravenous leiomyomatosis 10.2 MME CALD1
20 cervical polyp 10.2 MME CALD1
21 ureter squamous cell carcinoma 10.2 KRT7 KRT5
22 inverted transitional papilloma 10.2 KRT7 KRT5
23 endometrial stromal nodule 10.2 MME CALD1
24 ureter adenocarcinoma 10.2 KRT7 KRT5
25 ceruminoma 10.2 KRT7 KRT5
26 malignant acrospiroma 10.2 KRT7 KRT5
27 vulvar leiomyoma 10.2 MME CALD1
28 cellular leiomyoma 10.1 MME CALD1
29 atypical polypoid adenomyoma 10.1 MME CALD1
30 microinvasive cervical squamous cell carcinoma 10.1 KRT7 KRT5
31 cutaneous mucoepidermoid carcinoma 10.1 KRT7 KRT5
32 auditory system benign neoplasm 10.1 KRT7 KRT5
33 ceruminous adenocarcinoma 10.1 KRT7 KRT5
34 eccrine adenocarcinoma 10.1 KRT7 KRT5
35 cervix erosion 10.1 MME KRT5
36 external ear carcinoma 10.1 KRT7 KRT5
37 vulvar apocrine adenocarcinoma 10.1 KRT7 KRT5
38 apocrine adenocarcinoma 10.1 KRT7 KRT5
39 breast leiomyosarcoma 10.1 KRT7 CALD1
40 ovarian endometrioid stromal sarcoma 10.1 MME CALD1
41 middle ear adenoma 10.1 KRT7 KRT5
42 lung clear cell carcinoma 10.1 KRT7 KRT5
43 gastric squamous cell carcinoma 10.1 KRT7 KRT5
44 necrotizing sialometaplasia 10.1 KRT7 KRT5
45 endobronchial leiomyoma 10.1 MME CALD1
46 sensory organ benign neoplasm 10.1 KRT7 KRT5
47 breast metaplastic carcinoma 10.1 MME KRT5
48 bile duct mucoepidermoid carcinoma 10.1 KRT7 KRT5
49 breast mucinous carcinoma 10.1 KRT7 KRT5
50 middle ear adenocarcinoma 10.1 KRT7 KRT5

Graphical network of the top 20 diseases related to Nipple Benign Neoplasm:



Diseases related to Nipple Benign Neoplasm

Symptoms & Phenotypes for Nipple Benign Neoplasm

GenomeRNAi Phenotypes related to Nipple Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.1 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.1 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.1 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.1 KRT5 KRT7 KRT8

Drugs & Therapeutics for Nipple Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Nipple Benign Neoplasm

Genetic Tests for Nipple Benign Neoplasm

Anatomical Context for Nipple Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Nipple Benign Neoplasm:

19
Nipple

MalaCards organs/tissues related to Nipple Benign Neoplasm:

40
Breast

Publications for Nipple Benign Neoplasm

Variations for Nipple Benign Neoplasm

Expression for Nipple Benign Neoplasm

Search GEO for disease gene expression data for Nipple Benign Neoplasm.

Pathways for Nipple Benign Neoplasm

Pathways related to Nipple Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 KRT8 KRT7 KRT5
2 11.51 KRT8 KRT7 KRT5 CNN1 CALD1
3
Show member pathways
11.17 KRT8 KRT7 KRT5
4 11.13 MME KRT8

GO Terms for Nipple Benign Neoplasm

Cellular components related to Nipple Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.13 KRT8 KRT7 KRT5
2 keratin filament GO:0045095 8.8 KRT8 KRT7 KRT5

Biological processes related to Nipple Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.13 KRT8 KRT7 KRT5
2 cornification GO:0070268 8.8 KRT8 KRT7 KRT5

Molecular functions related to Nipple Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.62 KRT8 KRT5

Sources for Nipple Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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