MCID: NPP002
MIFTS: 21

Nipple Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Nipple Carcinoma

MalaCards integrated aliases for Nipple Carcinoma:

Name: Nipple Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:6629
NCIt 50 C28432
UMLS 71 C1334966

Summaries for Nipple Carcinoma

Disease Ontology : 12 A breast carcinoma that is located in the nipple.

MalaCards based summary : Nipple Carcinoma is related to nipple duct carcinoma and cervical adenocarcinoma. An important gene associated with Nipple Carcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Gastric cancer and Development Ligand-independent activation of ESR1 and ESR2. Affiliated tissues include nipple, and related phenotypes are limbs/digits/tail and neoplasm

Related Diseases for Nipple Carcinoma

Diseases related to Nipple Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 nipple duct carcinoma 11.0
2 cervical adenocarcinoma 10.0 ESR1 ERBB2
3 breast squamous cell carcinoma 10.0 ESR1 ERBB2
4 uterine body mixed cancer 10.0 ESR1 ERBB2
5 bartholin's gland adenoma 9.9 PGR ESR1
6 bartholin's gland adenoid cystic carcinoma 9.9 PGR ESR1
7 uterine corpus adenosarcoma 9.9 PGR ESR1
8 bartholin's gland benign neoplasm 9.9 PGR ESR1
9 chronic tympanitis 9.9 PGR ESR1
10 vestibular gland benign neoplasm 9.9 PGR ESR1
11 granulomatous endometritis 9.9 PGR ESR1
12 endometritis 9.9 PGR ESR1
13 vulvar syringoma 9.9 PGR ESR1
14 lung leiomyoma 9.9 PGR ESR1
15 leiomyoma 9.9 PGR ESR1
16 myoma 9.9 PGR ESR1
17 adult type testicular granulosa cell tumor 9.9 PGR ESR1
18 cervical clear cell adenocarcinoma 9.9 PGR ESR1
19 ovarian seromucinous carcinoma 9.9 PGR ESR1
20 liver leiomyoma 9.9 PGR ESR1
21 intravenous leiomyomatosis 9.9 PGR ESR1
22 leiomyomatosis 9.9 PGR ESR1
23 intracranial meningioma 9.9 PGR ESR1
24 vulvar leiomyoma 9.9 PGR ESR1
25 bizarre leiomyoma 9.9 PGR ESR1
26 breast adenoma 9.9 PGR ESR1
27 prostate stromal sarcoma 9.9 PGR ESR1
28 urethral benign neoplasm 9.9 PGR ESR1
29 cervical adenosarcoma 9.9 PGR ESR1
30 gender identity disorder 9.9 PGR ESR1
31 progesterone resistance 9.9 PGR ESR1
32 biphasic synovial sarcoma 9.9 PGR ESR1
33 vaginal cancer 9.9 PGR ESR1
34 juvenile nasopharyngeal angiofibroma 9.9 PGR ESR1
35 trigonitis 9.9 PGR ESR1
36 ovarian endometrial cancer 9.9 PGR ESR1
37 vaginal discharge 9.9 PGR ESR1
38 vulvar benign neoplasm 9.9 PGR ESR1
39 estrogen excess 9.9 PGR ESR1
40 endometriosis of ovary 9.8 PGR ESR1
41 endometriosis 9.8 PGR ESR1
42 scirrhous adenocarcinoma 9.8 PGR ERBB2
43 lipid-rich breast carcinoma 9.8 PGR ERBB2
44 endometrial disease 9.8 PGR ESR1
45 apocrine adenosis of breast 9.8 PGR ERBB2
46 luminal breast carcinoma b 9.8 PGR ERBB2
47 prostatic hypertrophy 9.8 PGR ESR1
48 smooth muscle tumor 9.8 PGR ESR1
49 breast mucinous carcinoma 9.8 PGR ERBB2
50 endometrial stromal tumor 9.8 PGR ESR1

Graphical network of the top 20 diseases related to Nipple Carcinoma:



Diseases related to Nipple Carcinoma

Symptoms & Phenotypes for Nipple Carcinoma

MGI Mouse Phenotypes related to Nipple Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.13 ERBB2 ESR1 PGR
2 neoplasm MP:0002006 8.8 ERBB2 ESR1 PGR

Drugs & Therapeutics for Nipple Carcinoma

Search Clinical Trials , NIH Clinical Center for Nipple Carcinoma

Genetic Tests for Nipple Carcinoma

Anatomical Context for Nipple Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Nipple Carcinoma:

19
Nipple

Publications for Nipple Carcinoma

Articles related to Nipple Carcinoma:

# Title Authors PMID Year
1
Development of an invasive ductal carcinoma in a contralateral composite nipple graft after an autologous breast reconstruction: a case report. 61
32770432 2020
2
Gynecomastia of the male nipple. 61
9641293 1998

Variations for Nipple Carcinoma

Expression for Nipple Carcinoma

Search GEO for disease gene expression data for Nipple Carcinoma.

Pathways for Nipple Carcinoma

Pathways related to Nipple Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.8 PGR ESR1 ERBB2
2
Show member pathways
11.73 ESR1 ERBB2
3 11.68 ESR1 ERBB2
4
Show member pathways
11.57 PGR ESR1
5
Show member pathways
11.23 ESR1 ERBB2
6
Show member pathways
11.11 PGR ESR1
7
Show member pathways
10.83 PGR ESR1 ERBB2

GO Terms for Nipple Carcinoma

Biological processes related to Nipple Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.26 ESR1 ERBB2
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.16 PGR ESR1
3 steroid hormone mediated signaling pathway GO:0043401 8.96 PGR ESR1
4 intracellular steroid hormone receptor signaling pathway GO:0030518 8.62 PGR ESR1

Molecular functions related to Nipple Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase binding GO:0051117 9.26 PGR ESR1
2 nuclear receptor activity GO:0004879 9.16 PGR ESR1
3 steroid binding GO:0005496 8.96 PGR ESR1
4 steroid hormone receptor activity GO:0003707 8.62 PGR ESR1

Sources for Nipple Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....