Nipple Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Nipple Carcinoma

MalaCards integrated aliases for Nipple Carcinoma:

Name: Nipple Carcinoma ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6629

NCIt ⁵⁰ C28432

UMLS ⁷¹ C1334966

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Summaries for Nipple Carcinoma

Disease Ontology : ¹² A breast carcinoma that is located in the nipple.

MalaCards based summary : Nipple Carcinoma is related to nipple duct carcinoma and cervical adenocarcinoma. An important gene associated with Nipple Carcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Gastric cancer and Development Ligand-independent activation of ESR1 and ESR2. Affiliated tissues include nipple, and related phenotypes are limbs/digits/tail and neoplasm

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Related Diseases for Nipple Carcinoma

Diseases related to Nipple Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)

#	Related Disease	Score	Top Affiliating Genes
1	nipple duct carcinoma	11.0
2	cervical adenocarcinoma	10.0	ESR1 ERBB2
3	breast squamous cell carcinoma	10.0	ESR1 ERBB2
4	uterine body mixed cancer	10.0	ESR1 ERBB2
5	bartholin's gland adenoma	9.9	PGR ESR1
6	bartholin's gland adenoid cystic carcinoma	9.9	PGR ESR1
7	uterine corpus adenosarcoma	9.9	PGR ESR1
8	bartholin's gland benign neoplasm	9.9	PGR ESR1
9	chronic tympanitis	9.9	PGR ESR1
10	vestibular gland benign neoplasm	9.9	PGR ESR1
11	granulomatous endometritis	9.9	PGR ESR1
12	endometritis	9.9	PGR ESR1
13	vulvar syringoma	9.9	PGR ESR1
14	lung leiomyoma	9.9	PGR ESR1
15	leiomyoma	9.9	PGR ESR1
16	myoma	9.9	PGR ESR1
17	adult type testicular granulosa cell tumor	9.9	PGR ESR1
18	cervical clear cell adenocarcinoma	9.9	PGR ESR1
19	ovarian seromucinous carcinoma	9.9	PGR ESR1
20	liver leiomyoma	9.9	PGR ESR1
21	intravenous leiomyomatosis	9.9	PGR ESR1
22	leiomyomatosis	9.9	PGR ESR1
23	intracranial meningioma	9.9	PGR ESR1
24	vulvar leiomyoma	9.9	PGR ESR1
25	bizarre leiomyoma	9.9	PGR ESR1
26	breast adenoma	9.9	PGR ESR1
27	prostate stromal sarcoma	9.9	PGR ESR1
28	urethral benign neoplasm	9.9	PGR ESR1
29	cervical adenosarcoma	9.9	PGR ESR1
30	gender identity disorder	9.9	PGR ESR1
31	progesterone resistance	9.9	PGR ESR1
32	biphasic synovial sarcoma	9.9	PGR ESR1
33	vaginal cancer	9.9	PGR ESR1
34	juvenile nasopharyngeal angiofibroma	9.9	PGR ESR1
35	trigonitis	9.9	PGR ESR1
36	ovarian endometrial cancer	9.9	PGR ESR1
37	vaginal discharge	9.9	PGR ESR1
38	vulvar benign neoplasm	9.9	PGR ESR1
39	estrogen excess	9.9	PGR ESR1
40	endometriosis of ovary	9.8	PGR ESR1
41	endometriosis	9.8	PGR ESR1
42	scirrhous adenocarcinoma	9.8	PGR ERBB2
43	lipid-rich breast carcinoma	9.8	PGR ERBB2
44	endometrial disease	9.8	PGR ESR1
45	apocrine adenosis of breast	9.8	PGR ERBB2
46	luminal breast carcinoma b	9.8	PGR ERBB2
47	prostatic hypertrophy	9.8	PGR ESR1
48	smooth muscle tumor	9.8	PGR ESR1
49	breast mucinous carcinoma	9.8	PGR ERBB2
50	endometrial stromal tumor	9.8	PGR ESR1

Graphical network of the top 20 diseases related to Nipple Carcinoma:

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Symptoms & Phenotypes for Nipple Carcinoma

MGI Mouse Phenotypes related to Nipple Carcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail	MP:0005371	9.13	ERBB2 ESR1 PGR
2	neoplasm	MP:0002006	8.8	ERBB2 ESR1 PGR

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Drugs & Therapeutics for Nipple Carcinoma

Search Clinical Trials , NIH Clinical Center for Nipple Carcinoma

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Genetic Tests for Nipple Carcinoma

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Anatomical Context for Nipple Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Nipple Carcinoma:

¹⁹

Nipple

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Publications for Nipple Carcinoma

Articles related to Nipple Carcinoma:

#	Title	Authors	PMID	Year
1	Development of an invasive ductal carcinoma in a contralateral composite nipple graft after an autologous breast reconstruction: a case report. ⁶¹	Kimura M...Endo I	32770432	2020
2	Gynecomastia of the male nipple. ⁶¹	Liebau J...Berger A	9641293	1998

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Genes for Nipple Carcinoma

Genes related to Nipple Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	5	DISEASES inferred ¹⁵
2	PGR	Progesterone Receptor	Protein Coding	4.7	DISEASES inferred ¹⁵
3	ESR1	Estrogen Receptor 1	Protein Coding	4.34	DISEASES inferred ¹⁵

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Variations for Nipple Carcinoma

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Expression for Nipple Carcinoma

Search GEO for disease gene expression data for Nipple Carcinoma.

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Pathways for Nipple Carcinoma

Pathways related to Nipple Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	11.8	PGR ESR1 ERBB2
2	Development Ligand-independent activation of ESR1 and ESR2 ²³ Show member pathways Transcription CREB pathway ²³ Transcription PPAR Pathway ²³	11.73	ESR1 ERBB2
3	Proteoglycans in cancer ³⁶	11.68	ESR1 ERBB2
4	Cell cycle Role of SCF complex in cell cycle regulation ²³ Show member pathways Cell cycle ESR1 regulation of G1/S transition ²³ Cell cycle Regulation of G1/S transition (part 1) ²³ Immune response MIF-JAB1 signaling ²³	11.57	PGR ESR1
5	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁵ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁵ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁵ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁵ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁵ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁵ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁵	11.23	ESR1 ERBB2
6	Nuclear Receptor transcription pathway ⁶⁵ Show member pathways Nuclear Receptors ¹	11.11	PGR ESR1
7	Signaling by ERBB4 ⁶⁵ Show member pathways Downregulation of ERBB4 signaling ⁶⁵ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁵	10.83	PGR ESR1 ERBB2

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GO Terms for Nipple Carcinoma

Biological processes related to Nipple Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of protein kinase B signaling	GO:0051897	9.26	ESR1 ERBB2
2	transcription initiation from RNA polymerase II promoter	GO:0006367	9.16	PGR ESR1
3	steroid hormone mediated signaling pathway	GO:0043401	8.96	PGR ESR1
4	intracellular steroid hormone receptor signaling pathway	GO:0030518	8.62	PGR ESR1

Molecular functions related to Nipple Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATPase binding	GO:0051117	9.26	PGR ESR1
2	nuclear receptor activity	GO:0004879	9.16	PGR ESR1
3	steroid binding	GO:0005496	8.96	PGR ESR1
4	steroid hormone receptor activity	GO:0003707	8.62	PGR ESR1

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Sources for Nipple Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia