MCID: NPP003
MIFTS: 25

Nipple Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Nipple Neoplasm

MalaCards integrated aliases for Nipple Neoplasm:

Name: Nipple Neoplasm 12 15 71
Nipple Carcinoma 71
Tumor of Nipple 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3003
NCIt 49 C5212
UMLS 71 C1112166 C1334966

Summaries for Nipple Neoplasm

Disease Ontology : 12 A breast benign neoplasm that is located in the nipple.

MalaCards based summary : Nipple Neoplasm, also known as nipple carcinoma, is related to nephrogenic adenofibroma and vaginal benign neoplasm. An important gene associated with Nipple Neoplasm is CNN1 (Calponin 1), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. Affiliated tissues include nipple, breast and thymus, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Nipple Neoplasm

Diseases related to Nipple Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 nephrogenic adenofibroma 10.2 KRT7 CALD1
2 vaginal benign neoplasm 10.1 KRT7 CALD1
3 testicular fibroma 10.1 KRT5 CALD1
4 sarcomatous intrahepatic cholangiocarcinoma 10.1 KRT7 CALD1
5 inverted transitional papilloma 10.1 KRT7 KRT5
6 malignant spiradenoma 10.1 KRT7 KRT5
7 ceruminoma 10.1 KRT7 KRT5
8 ureter adenocarcinoma 10.1 KRT7 KRT5
9 benign breast adenomyoepithelioma 10.1 KRT7 KRT5
10 breast adenomyoepithelioma 10.1 KRT7 KRT5
11 bladder leiomyoma 10.1 KRT7 CALD1
12 microinvasive cervical squamous cell carcinoma 10.1 KRT7 KRT5
13 external ear carcinoma 10.1 KRT5 KRT7
14 ceruminous adenocarcinoma 10.1 KRT7 KRT5
15 vulvar apocrine adenocarcinoma 10.1 KRT7 KRT5
16 apocrine adenocarcinoma 10.1 KRT7 KRT5
17 gastric squamous cell carcinoma 10.1 KRT7 KRT5
18 middle ear adenoma 10.1 KRT7 KRT5
19 myoma 10.1 MME CALD1
20 breast myoepithelial neoplasm 10.1 KRT7 KRT5
21 breast leiomyosarcoma 10.1 KRT7 CALD1
22 necrotizing sialometaplasia 10.1 KRT7 KRT5
23 mixed endometrial stromal and smooth muscle tumor 10.1 MME CALD1
24 sensory organ benign neoplasm 10.1 KRT7 KRT5
25 smooth muscle tumor 10.1 MME CALD1
26 fallopian tube leiomyoma 10.1 MME CALD1
27 urethra leiomyoma 10.1 MME CALD1
28 bile duct mucoepidermoid carcinoma 10.1 KRT7 KRT5
29 fallopian tube benign neoplasm 10.1 MME CALD1
30 breast metaplastic carcinoma 10.1 KRT7 KRT5
31 breast mucinous carcinoma 10.1 KRT7 KRT5
32 breast myofibroblastoma 10.1 MME CALD1
33 eccrine sweat gland cancer 10.1 KRT7 KRT5
34 middle ear adenocarcinoma 10.1 KRT7 KRT5
35 lung combined type small cell carcinoma 10.1 MME CALD1
36 metatypical basal cell carcinoma 10.1 KRT7 KRT5
37 benign mesothelioma 10.1 KRT7 KRT5
38 pericardium cancer 10.1 KRT7 KRT5
39 eccrine acrospiroma 10.1 KRT7 KRT5
40 vaginal cancer 10.1 KRT7 CALD1
41 papillary squamous carcinoma 10.1 KRT7 KRT5
42 large cell acanthoma 10.1 KRT7 KRT5
43 benign mesenchymoma 10.1 KRT7 KRT5
44 intravenous leiomyomatosis 10.1 MME CALD1
45 eccrine porocarcinoma 10.1 KRT7 KRT5
46 lung clear cell carcinoma 10.1 KRT7 KRT5
47 esophageal adenosquamous carcinoma 10.1 KRT7 KRT5
48 cervical polyp 10.1 MME CALD1
49 atypical polypoid adenomyoma 10.1 MME CALD1
50 thymus clear cell carcinoma 10.1 KRT7 KRT5

Graphical network of the top 20 diseases related to Nipple Neoplasm:



Diseases related to Nipple Neoplasm

Symptoms & Phenotypes for Nipple Neoplasm

GenomeRNAi Phenotypes related to Nipple Neoplasm according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.65 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.65 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.65 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.65 KRT7
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.65 KRT5 KRT7 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.65 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.65 KRT5 KRT7
8 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.28 KRT8
9 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.28 KRT7 KRT8
10 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.28 KRT8
11 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.28 KRT7 KRT8
12 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.28 KRT8
13 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.28 KRT7 KRT8

Drugs & Therapeutics for Nipple Neoplasm

Search Clinical Trials , NIH Clinical Center for Nipple Neoplasm

Genetic Tests for Nipple Neoplasm

Anatomical Context for Nipple Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Nipple Neoplasm:

19
Nipple

MalaCards organs/tissues related to Nipple Neoplasm:

40
Breast, Thymus, Smooth Muscle, Kidney, Lung, Bone, Heart

Publications for Nipple Neoplasm

Articles related to Nipple Neoplasm:

# Title Authors PMID Year
1
Gynecomastia of the male nipple. 61
9641293 1998

Variations for Nipple Neoplasm

Expression for Nipple Neoplasm

Search GEO for disease gene expression data for Nipple Neoplasm.

Pathways for Nipple Neoplasm

Pathways related to Nipple Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 KRT8 KRT7 KRT5
2 11.51 KRT8 KRT7 KRT5 CNN1 CALD1
3
Show member pathways
11.17 KRT8 KRT7 KRT5
4 11.13 MME KRT8

GO Terms for Nipple Neoplasm

Cellular components related to Nipple Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.13 KRT8 KRT7 KRT5
2 keratin filament GO:0045095 8.8 KRT8 KRT7 KRT5

Biological processes related to Nipple Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.13 KRT8 KRT7 KRT5
2 cornification GO:0070268 8.8 KRT8 KRT7 KRT5

Molecular functions related to Nipple Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.62 KRT8 KRT5

Sources for Nipple Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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