MCID: NPP006
MIFTS: 28

Nipples, Supernumerary

Categories: Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Nipples, Supernumerary

MalaCards integrated aliases for Nipples, Supernumerary:

Name: Nipples, Supernumerary 57 54
Supernumerary Nipple 20 29
Accessory Nipple 20 32
Familial Supernumerary Nipples 58
Polythelia, Familial 57
Isolated Polythelia 58
Accessory Nipples 57
Ectopic Nipple 20
Extra Nipple 20
Polymastia 57

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant


HPO:

31
nipples, supernumerary:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

OMIM® 57 163700
ICD10 32 Q83.3
ICD10 via Orphanet 33 Q83.3
UMLS via Orphanet 71 C0266011
Orphanet 58 ORPHA2456
MedGen 41 C0266011

Summaries for Nipples, Supernumerary

GARD : 20 A supernumerary nipple is a common, minor birth defect that consists of an extra nipple (and/or related tissue ) in addition to the two nipples that normally appear on the chest. Most supernumerary nipples do not cause symptoms or complications. They often are small and go undetected. Sometimes they are first noticed during puberty, menstruation, or pregnancy when hormonal changes affect breast tissue. They can be present with no other tissue (polythelia); with some related tissue; or with breast tissue and ducts (then referred to as polymastia). They are usually located along areas of the body known as the "embryonic milk lines," the lines of potentially appearing breast tissue. The embryonic milk lines extend on both sides of the body from slightly above the armpit, down the chest and abdomen, to the inner thighs near the groin. Supernumerary nipples are usually not inherited but familial cases have been reported. Most people do not need treatment, but the nipple and related tissue can be removed for cosmetic purposes or if there is discomfort.

MalaCards based summary : Nipples, Supernumerary, also known as supernumerary nipple, is related to mammary paget's disease and supernumerary breasts. An important gene associated with Nipples, Supernumerary is GPC3 (Glypican 3). Affiliated tissues include breast, kidney and skin, and related phenotypes are supernumerary nipple and abnormality of the genitourinary system

Wikipedia : 73 A supernumerary nipple is an additional nipple occurring in mammals, including humans. They are often... more...

More information from OMIM: 163700

Related Diseases for Nipples, Supernumerary

Diseases related to Nipples, Supernumerary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 mammary paget's disease 29.6 PIP KRT20
2 supernumerary breasts 11.4
3 adenoma 10.1
4 cystic kidney disease 10.1
5 glioma 10.0
6 glial tumor 10.0
7 orthostatic intolerance 10.0
8 posttransplant acute limbic encephalitis 10.0
9 breast cancer 9.9
10 lipomatosis, multiple 9.9
11 dowling-degos disease 1 9.9
12 becker nevus syndrome 9.9
13 pleomorphic lipoma 9.9
14 hypothyroidism 9.9
15 lymphangioma 9.9
16 lymphangiosarcoma 9.9
17 seminoma 9.9
18 skin tag 9.9
19 keloid disorder 9.9
20 erythrokeratoderma ''en cocardes'' 9.9
21 testicular seminoma 9.9
22 rare lymphatic malformation 9.9
23 myhre syndrome 9.9
24 adenoid hypertrophy 9.9
25 papilledema 9.9
26 cutaneous fibrous histiocytoma 9.9
27 cataract 9.9
28 seminal vesicle adenocarcinoma 9.9 KRT20 GPC3
29 polykaryocytosis inducer 9.9
30 pachyonychia congenita 3 9.9
31 kidney cancer 9.9
32 neuroblastoma 9.9
33 anaplastic oligoastrocytoma 9.9
34 gigantomastia 9.9
35 benign mesothelioma 9.9 KRT20 GPC3
36 lung acinar adenocarcinoma 9.8 PIP KRT20
37 vulva adenocarcinoma 9.8 PIP KRT20
38 vulvar apocrine adenocarcinoma 9.8 PIP KRT20
39 eyelid carcinoma 9.8 PIP KRT20
40 malignant syringoma 9.8 PIP KRT20
41 anal canal adenocarcinoma 9.8 PIP KRT20
42 gastric diffuse adenocarcinoma 9.8 PIP KRT20
43 eccrine sweat gland cancer 9.8 PIP KRT20
44 sweat gland cancer 9.8 PIP KRT20
45 linitis plastica 9.8 PIP KRT20
46 peritoneal serous adenocarcinoma 9.8 PIP KRT20
47 papillary cystadenocarcinoma 9.8 PIP KRT20
48 intrahepatic cholangiocarcinoma 9.8 KRT20 GPC3
49 breast neuroendocrine neoplasm 9.8 PIP KRT20
50 cystic basal cell carcinoma 9.8 PIP KRT20

Graphical network of the top 20 diseases related to Nipples, Supernumerary:



Diseases related to Nipples, Supernumerary

Symptoms & Phenotypes for Nipples, Supernumerary

Human phenotypes related to Nipples, Supernumerary:

58 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 supernumerary nipple 58 31 hallmark (90%) Very frequent (99-80%) HP:0002558
2 abnormality of the genitourinary system 58 31 occasional (7.5%) Occasional (29-5%) HP:0000119
3 abnormality of the kidney 31 HP:0000077
4 abnormal thorax morphology 31 HP:0000765

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Chest Breasts:
accessory breast
supernumerary nipples (polythelia)

Clinical features from OMIM®:

163700 (Updated 20-May-2021)

Drugs & Therapeutics for Nipples, Supernumerary

Search Clinical Trials , NIH Clinical Center for Nipples, Supernumerary

Genetic Tests for Nipples, Supernumerary

Genetic tests related to Nipples, Supernumerary:

# Genetic test Affiliating Genes
1 Supernumerary Nipple 29

Anatomical Context for Nipples, Supernumerary

MalaCards organs/tissues related to Nipples, Supernumerary:

40
Breast, Kidney, Skin, Lung, Heart

Publications for Nipples, Supernumerary

Articles related to Nipples, Supernumerary:

(show top 50) (show all 62)
# Title Authors PMID Year
1
Supernumerary nipples: prevalence, size, sex and side predilection -- a prospective clinical study. 61 57
9809822 1998
2
Duplication of the nipples and areolae. 57
17351357 2007
3
Supernumerary nipples occurring together with Becker's naevus: an association involving one common paradominant trait? 57
9272160 1997
4
The significance of familial polythelia. 57
7896973 1995
5
Familial polythelia. 57
7755675 1994
6
Familial supernumerary nipples. 57
3228141 1988
7
Association of supernumerary nipples with renal anomalies. 57
3305849 1987
8
Aberrant axillary breast tissue: A report of a family with six affected women in two generations. 57
991442 1976
9
Nervous Nipple: Pseudopolythelia Caused by a Neurofibroma of the Areola. 61
33577179 2021
10
Management of ipsilateral supernumerary nipple at time of breast cancer diagnosis. 61
32729645 2020
11
Syringomatous Tumour Presenting as Inversion of a Supernumerary Nipple. 61
30792933 2019
12
Accessory nipple over the right scapula of a 14-year-old boy: An extremely rare and unreported location, case report. 61
30684816 2019
13
Supernumerary nipple in a young woman. 61
31762904 2019
14
A Supernumerary Nipple-Like Clinical Presentation of Lymphangioma Circumscriptum. 61
29796322 2018
15
A genome-wide association study reveals candidate genes for the supernumerary nipple phenotype in sheep (Ovis aries). 61
28703336 2017
16
Perinatal Case of Fatal Simpson-Golabi-Behmel Syndrome with Hyperplasia of Seminiferous Tubules. 61
28600484 2017
17
A brother and sister with breast cancer, BRCA2 mutations and bilateral supernumerary nipples. 61
28361071 2017
18
A chromosome 1q44 deletion in a 4-month-old girl; The first report in Korea. 61
25076975 2014
19
Congenital anomalies of the breast. 61
24872738 2013
20
An ectopic breast tissue presenting with fibroadenoma in axilla. 61
23607040 2013
21
Supernumerary nipple and seminoma: case report and review of polythelia and genitourinary cancers. 61
23374946 2013
22
Sostdc1 defines the size and number of skin appendage placodes. 61
22509524 2012
23
[Polythelia and supernumerary breast. Personal experience and review of the literature]. 61
22462329 2012
24
Syringomatous adenoma occurring within a supernumerary nipple. 61
22016297 2011
25
Lactation adenoma in a supernumerary nipple. 61
21366661 2011
26
Nodular mucinosis of the breast in a supernumerary nipple: case report and review of the literature. 61
19694882 2010
27
Supernumerary nipple: should we be alert? 61
20958861 2010
28
In vivo reflectance confocal microscopy of supernumerary nipple and differential diagnosis from melanocytic lesions. 61
19614734 2010
29
Supernumerary nipple presenting as a vulvar mass in an adolescent: case report and literature review. 61
19493516 2009
30
Branchio-oculo-facial syndrome (BOFS) and congenital heart defects. 61
19360235 2009
31
Accessory nipple reconstruction following a central quadrantectomy: a case report. 61
19133154 2009
32
[External periareolar incision for subdermal mastectomy in men with gynecomastia]. 61
18158877 2007
33
[Breast abnormalities: a retrospective study of 208 patients]. 61
17966771 2007
34
Pigment network: a clue to dermatoscopic diagnosis of melanocytic lesions--supernumerary nipple: another exception to the rule. 61
15209804 2004
35
Supernumerary nipple and cardiocutaneous associations. 61
15153916 2004
36
Supernumerary nipples and renal malformations: a family study. 61
15578130 2004
37
Clear cells of Toker in accessory nipples. 54
12680957 2003
38
Toker cells are probably precursors of Paget cell carcinoma: a morphological and ultrastructural description. 61
12189500 2002
39
GPC3 mutation analysis in a spectrum of patients with overgrowth expands the phenotype of Simpson-Golabi-Behmel syndrome. 54
11477610 2001
40
[Complete supernumerary breast on the thigh in a male patient]. 61
11275593 2001
41
Amniotic band sequence versus the autosomal recessive microcephaly, facial clefting, and preaxial polydactyly syndrome. 61
11045592 2000
42
Supernumerary nipple as a cutaneous marker of mitral valve prolapse in Asian Indians. 61
10980229 2000
43
A case of lipoma associated with a supernumerary nipple-areola complex. 61
10402998 1999
44
A puzzling case of palpable hyperpigmentation. Polythelia, or supernumerary nipple. 61
9861260 1998
45
Supernumerary nipple in association with Becker nevus vs. Becker nevus syndrome: a semantic problem only. 61
9557899 1998
46
Paget's disease versus Toker cell hyperplasia in a supernumerary nipple. 61
9532009 1998
47
Accessory mammary tissue associated with congenital and hereditary nephrourinary malformations. 61
8734657 1996
48
Aberrant mammary tissue and nephrourinary malignancy. 61
8646751 1996
49
Familial association of supernumerary nipple with renal cancer. 61
8603338 1996
50
Lactation from axillary breast tissue in the absence of a supernumerary nipple. A case report. 61
7996535 1994

Variations for Nipples, Supernumerary

Expression for Nipples, Supernumerary

Search GEO for disease gene expression data for Nipples, Supernumerary.

Pathways for Nipples, Supernumerary

GO Terms for Nipples, Supernumerary

Sources for Nipples, Supernumerary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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