MCID: NPP006
MIFTS: 31

Nipples, Supernumerary

Categories: Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Nipples, Supernumerary

MalaCards integrated aliases for Nipples, Supernumerary:

Name: Nipples, Supernumerary 58 56
Supernumerary Nipple 54 30
Familial Supernumerary Nipples 60
Polythelia, Familial 58
Isolated Polythelia 60
Accessory Nipples 58
Accessory Nipple 54
Ectopic Nipple 54
Extra Nipple 54
Polymastia 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
nipples, supernumerary:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 58 163700
ICD10 34 Q83.3
ICD10 via Orphanet 35 Q83.3
UMLS via Orphanet 75 C0266011
Orphanet 60 ORPHA2456
MedGen 43 C0266011

Summaries for Nipples, Supernumerary

NIH Rare Diseases : 54 A supernumerary nipple is a common, minor birth defect that consists of an extra nipple (and/or related tissue) in addition to the two nipples that normally appear on the chest. Most supernumerary nipples do not cause symptoms or complications. They often are small and go undetected. Sometimes they are first noticed during puberty, menstruation, or pregnancy when hormonal changes affect breast tissue. They can be present with no other tissue (polythelia); with some related tissue; or with breast tissue and ducts (then referred to as polymastia). They are usually located along areas of the body known as the "embryonic milk lines," the lines of potentially appearing breast tissue. The embryonic milk lines extend on both sides of the body from slightly above the armpit, down the chest and abdomen, to the inner thighs near the groin. Supernumerary nipples are usually not inherited but familial cases have been reported. Most people do not need treatment, but the nipple and related tissue can be removed for cosmetic purposes or if there is discomfort.

MalaCards based summary : Nipples, Supernumerary, also known as supernumerary nipple, is related to supernumerary breasts and postaxial acrofacial dysostosis. An important gene associated with Nipples, Supernumerary is GPC3 (Glypican 3). Affiliated tissues include breast and kidney, and related phenotypes are supernumerary nipple and abnormality of the genitourinary system

Wikipedia : 77 A supernumerary nipple (also known as a third nipple, triple nipple, accessory nipple,polythelia or the... more...

Description from OMIM: 163700

Related Diseases for Nipples, Supernumerary

Graphical network of the top 20 diseases related to Nipples, Supernumerary:



Diseases related to Nipples, Supernumerary

Symptoms & Phenotypes for Nipples, Supernumerary

Human phenotypes related to Nipples, Supernumerary:

60 33
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 supernumerary nipple 60 33 hallmark (90%) Very frequent (99-80%) HP:0002558
2 abnormality of the genitourinary system 60 33 occasional (7.5%) Occasional (29-5%) HP:0000119
3 abnormality of the thorax 33 HP:0000765
4 abnormality of the kidney 33 HP:0000077

Symptoms via clinical synopsis from OMIM:

58
Chest Breasts:
accessory breast
supernumerary nipples (polythelia)

Clinical features from OMIM:

163700

Drugs & Therapeutics for Nipples, Supernumerary

Search Clinical Trials , NIH Clinical Center for Nipples, Supernumerary

Genetic Tests for Nipples, Supernumerary

Genetic tests related to Nipples, Supernumerary:

# Genetic test Affiliating Genes
1 Supernumerary Nipple 30

Anatomical Context for Nipples, Supernumerary

MalaCards organs/tissues related to Nipples, Supernumerary:

42
Breast, Kidney

Publications for Nipples, Supernumerary

Articles related to Nipples, Supernumerary:

(show all 27)
# Title Authors Year
1
Syringomatous Tumour Presenting as Inversion of a Supernumerary Nipple. ( 30792933 )
2019
2
A Supernumerary Nipple-Like Clinical Presentation of Lymphangioma Circumscriptum. ( 29796322 )
2018
3
A genome-wide association study reveals candidate genes for the supernumerary nipple phenotype in sheep (Ovis aries). ( 28703336 )
2017
4
Supernumerary nipple and seminoma: case report and review of polythelia and genitourinary cancers. ( 23374946 )
2013
5
Lactation adenoma in a supernumerary nipple. ( 21366661 )
2011
6
Syringomatous adenoma occurring within a supernumerary nipple. ( 22016297 )
2011
7
In vivo reflectance confocal microscopy of supernumerary nipple and differential diagnosis from melanocytic lesions. ( 19614734 )
2010
8
Nodular mucinosis of the breast in a supernumerary nipple: case report and review of the literature. ( 19694882 )
2010
9
Supernumerary nipple: should we be alert? ( 20958861 )
2010
10
Supernumerary nipple presenting as a vulvar mass in an adolescent: case report and literature review. ( 19493516 )
2009
11
Supernumerary nipple and cardiocutaneous associations. ( 15153916 )
2004
12
Pigment network: a clue to dermatoscopic diagnosis of melanocytic lesions--supernumerary nipple: another exception to the rule. ( 15209804 )
2004
13
Supernumerary nipple as a cutaneous marker of mitral valve prolapse in Asian Indians. ( 10980229 )
2000
14
A case of lipoma associated with a supernumerary nipple-areola complex. ( 10402998 )
1999
15
Paget's disease versus Toker cell hyperplasia in a supernumerary nipple. ( 9532009 )
1998
16
Supernumerary nipple in association with Becker nevus vs. Becker nevus syndrome: a semantic problem only. ( 9557899 )
1998
17
A puzzling case of palpable hyperpigmentation. Polythelia, or supernumerary nipple. ( 9861260 )
1998
18
Familial association of supernumerary nipple with renal cancer. ( 8603338 )
1996
19
Paget's disease in an adolescent arising in a supernumerary nipple. ( 7962832 )
1994
20
Lactation from axillary breast tissue in the absence of a supernumerary nipple. A case report. ( 7996535 )
1994
21
Does a supernumerary nipple/renal field defect exist? ( 3303914 )
1987
22
Polythelia (supernumerary nipple): an update. ( 3749995 )
1986
23
Arm tumor resembling a supernumerary nipple. ( 2990355 )
1985
24
Supernumerary nipple. A histologic study. ( 7276291 )
1981
25
A supernumerary nipple in a rare site. Report of a case. ( 7309980 )
1981
26
Supernumerary nipple. First case report in Iran. ( 151484 )
1977
27
Supernumerary nipple on the shoulder. ( 1017243 )
1976

Variations for Nipples, Supernumerary

Expression for Nipples, Supernumerary

Search GEO for disease gene expression data for Nipples, Supernumerary.

Pathways for Nipples, Supernumerary

GO Terms for Nipples, Supernumerary

Sources for Nipples, Supernumerary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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