MCID: NPP006
MIFTS: 31

Nipples, Supernumerary

Categories: Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Nipples, Supernumerary

MalaCards integrated aliases for Nipples, Supernumerary:

Name: Nipples, Supernumerary 57 55
Supernumerary Nipple 53 29
Familial Supernumerary Nipples 59
Polythelia, Familial 57
Isolated Polythelia 59
Accessory Nipples 57
Accessory Nipple 53
Ectopic Nipple 53
Extra Nipple 53
Polymastia 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
nipples, supernumerary:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 163700
Orphanet 59 ORPHA2456
ICD10 via Orphanet 34 Q83.3
UMLS via Orphanet 74 C0266011
MedGen 42 C0266011
ICD10 33 Q83.3

Summaries for Nipples, Supernumerary

NIH Rare Diseases : 53 A supernumerary nipple is a common, minor birth defect that consists of an extra nipple (and/or related tissue) in addition to the two nipples that normally appear on the chest. Most supernumerary nipples do not cause symptoms or complications. They often are small and go undetected. Sometimes they are first noticed during puberty, menstruation, or pregnancy when hormonal changes affect breast tissue. They can be present with no other tissue (polythelia); with some related tissue; or with breast tissue and ducts (then referred to as polymastia). They are usually located along areas of the body known as the "embryonic milk lines," the lines of potentially appearing breast tissue. The embryonic milk lines extend on both sides of the body from slightly above the armpit, down the chest and abdomen, to the inner thighs near the groin. Supernumerary nipples are usually not inherited but familial cases have been reported. Most people do not need treatment, but the nipple and related tissue can be removed for cosmetic purposes or if there is discomfort.

MalaCards based summary : Nipples, Supernumerary, also known as supernumerary nipple, is related to supernumerary breasts and postaxial acrofacial dysostosis. An important gene associated with Nipples, Supernumerary is GPC3 (Glypican 3). Affiliated tissues include breast, kidney and lung, and related phenotypes are supernumerary nipple and abnormality of the genitourinary system

Wikipedia : 76 A supernumerary nipple (also known as a third nipple, triple nipple, accessory nipple,polythelia or the... more...

Description from OMIM: 163700

Related Diseases for Nipples, Supernumerary

Graphical network of the top 20 diseases related to Nipples, Supernumerary:



Diseases related to Nipples, Supernumerary

Symptoms & Phenotypes for Nipples, Supernumerary

Symptoms via clinical synopsis from OMIM:

57
Chest Breasts:
accessory breast
supernumerary nipples (polythelia)


Clinical features from OMIM:

163700

Human phenotypes related to Nipples, Supernumerary:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 supernumerary nipple 59 32 hallmark (90%) Very frequent (99-80%) HP:0002558
2 abnormality of the genitourinary system 59 32 occasional (7.5%) Occasional (29-5%) HP:0000119
3 abnormality of the thorax 32 HP:0000765
4 abnormality of the kidney 32 HP:0000077

Drugs & Therapeutics for Nipples, Supernumerary

Search Clinical Trials , NIH Clinical Center for Nipples, Supernumerary

Genetic Tests for Nipples, Supernumerary

Genetic tests related to Nipples, Supernumerary:

# Genetic test Affiliating Genes
1 Supernumerary Nipple 29

Anatomical Context for Nipples, Supernumerary

MalaCards organs/tissues related to Nipples, Supernumerary:

41
Breast, Kidney, Lung

Publications for Nipples, Supernumerary

Articles related to Nipples, Supernumerary:

(show all 26)
# Title Authors Year
1
A Supernumerary Nipple-Like Clinical Presentation of Lymphangioma Circumscriptum. ( 29796322 )
2018
2
A genome-wide association study reveals candidate genes for the supernumerary nipple phenotype in sheep (Ovis aries). ( 28703336 )
2017
3
Supernumerary nipple and seminoma: case report and review of polythelia and genitourinary cancers. ( 23374946 )
2013
4
Lactation adenoma in a supernumerary nipple. ( 21366661 )
2011
5
Syringomatous adenoma occurring within a supernumerary nipple. ( 22016297 )
2011
6
In vivo reflectance confocal microscopy of supernumerary nipple and differential diagnosis from melanocytic lesions. ( 19614734 )
2010
7
Nodular mucinosis of the breast in a supernumerary nipple: case report and review of the literature. ( 19694882 )
2010
8
Supernumerary nipple: should we be alert? ( 20958861 )
2010
9
Supernumerary nipple presenting as a vulvar mass in an adolescent: case report and literature review. ( 19493516 )
2009
10
Supernumerary nipple and cardiocutaneous associations. ( 15153916 )
2004
11
Pigment network: a clue to dermatoscopic diagnosis of melanocytic lesions--supernumerary nipple: another exception to the rule. ( 15209804 )
2004
12
Supernumerary nipple as a cutaneous marker of mitral valve prolapse in Asian Indians. ( 10980229 )
2000
13
A case of lipoma associated with a supernumerary nipple-areola complex. ( 10402998 )
1999
14
Paget's disease versus Toker cell hyperplasia in a supernumerary nipple. ( 9532009 )
1998
15
Supernumerary nipple in association with Becker nevus vs. Becker nevus syndrome: a semantic problem only. ( 9557899 )
1998
16
A puzzling case of palpable hyperpigmentation. Polythelia, or supernumerary nipple. ( 9861260 )
1998
17
Familial association of supernumerary nipple with renal cancer. ( 8603338 )
1996
18
Paget's disease in an adolescent arising in a supernumerary nipple. ( 7962832 )
1994
19
Lactation from axillary breast tissue in the absence of a supernumerary nipple. A case report. ( 7996535 )
1994
20
Does a supernumerary nipple/renal field defect exist? ( 3303914 )
1987
21
Polythelia (supernumerary nipple): an update. ( 3749995 )
1986
22
Arm tumor resembling a supernumerary nipple. ( 2990355 )
1985
23
Supernumerary nipple. A histologic study. ( 7276291 )
1981
24
A supernumerary nipple in a rare site. Report of a case. ( 7309980 )
1981
25
Supernumerary nipple. First case report in Iran. ( 151484 )
1977
26
Supernumerary nipple on the shoulder. ( 1017243 )
1976

Variations for Nipples, Supernumerary

Expression for Nipples, Supernumerary

Search GEO for disease gene expression data for Nipples, Supernumerary.

Pathways for Nipples, Supernumerary

GO Terms for Nipples, Supernumerary

Sources for Nipples, Supernumerary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....