MCID: NPP006
MIFTS: 32

Nipples, Supernumerary

Categories: Rare diseases, Reproductive diseases, Genetic diseases

Aliases & Classifications for Nipples, Supernumerary

MalaCards integrated aliases for Nipples, Supernumerary:

Name: Nipples, Supernumerary 57 55
Supernumerary Nipple 53 29
Familial Supernumerary Nipples 59
Polythelia, Familial 57
Isolated Polythelia 59
Accessory Nipples 57
Accessory Nipple 53
Ectopic Nipple 53
Extra Nipple 53
Polymastia 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
nipples, supernumerary:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 163700
Orphanet 59 ORPHA2456
ICD10 via Orphanet 34 Q83.3
UMLS via Orphanet 74 C0266011
MedGen 42 C0266011
ICD10 33 Q83.3

Summaries for Nipples, Supernumerary

NIH Rare Diseases : 53 A supernumerary nipple is a common, minor birth defect that consists of an extra nipple (and/or related tissue) in addition to the two nipples that normally appear on the chest. Most supernumerary nipples do not cause symptoms or complications. They often are small and go undetected. Sometimes they are first noticed during puberty, menstruation, or pregnancy when hormonal changes affect breast tissue. They can be present with no other tissue (polythelia); with some related tissue; or with breast tissue and ducts (then referred to as polymastia). They are usually located along areas of the body known as the "embryonic milk lines," the lines of potentially appearing breast tissue. The embryonic milk lines extend on both sides of the body from slightly above the armpit, down the chest and abdomen, to the inner thighs near the groin. Supernumerary nipples are usually not inherited but familial cases have been reported. Most people do not need treatment, but the nipple and related tissue can be removed for cosmetic purposes or if there is discomfort.

MalaCards based summary : Nipples, Supernumerary, also known as supernumerary nipple, is related to supernumerary breasts and postaxial acrofacial dysostosis. An important gene associated with Nipples, Supernumerary is GPC3 (Glypican 3). Affiliated tissues include breast and kidney, and related phenotypes are abnormality of the genitourinary system and supernumerary nipple

Wikipedia : 76 A supernumerary nipple (also known as a third nipple, triple nipple, accessory nipple,polythelia or the... more...

Description from OMIM: 163700

Related Diseases for Nipples, Supernumerary

Graphical network of the top 20 diseases related to Nipples, Supernumerary:



Diseases related to Nipples, Supernumerary

Symptoms & Phenotypes for Nipples, Supernumerary

Symptoms via clinical synopsis from OMIM:

57
Chest Breasts:
accessory breast
supernumerary nipples (polythelia)


Clinical features from OMIM:

163700

Human phenotypes related to Nipples, Supernumerary:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the genitourinary system 59 32 occasional (7.5%) Occasional (29-5%) HP:0000119
2 supernumerary nipple 59 32 hallmark (90%) Very frequent (99-80%) HP:0002558
3 abnormality of the kidney 32 HP:0000077
4 abnormality of the thorax 32 HP:0000765

Drugs & Therapeutics for Nipples, Supernumerary

Search Clinical Trials , NIH Clinical Center for Nipples, Supernumerary

Genetic Tests for Nipples, Supernumerary

Genetic tests related to Nipples, Supernumerary:

# Genetic test Affiliating Genes
1 Supernumerary Nipple 29

Anatomical Context for Nipples, Supernumerary

MalaCards organs/tissues related to Nipples, Supernumerary:

41
Breast, Kidney

Publications for Nipples, Supernumerary

Articles related to Nipples, Supernumerary:

(show all 47)
# Title Authors Year
1
A Supernumerary Nipple-Like Clinical Presentation of Lymphangioma Circumscriptum. ( 29796322 )
2018
2
Supernumerary nipples - a new finding in Williams syndrome. ( 26862942 )
2016
3
Supernumerary nipple and seminoma: case report and review of polythelia and genitourinary cancers. ( 23374946 )
2013
4
Congenital scoliosis, supernumerary nipples and spina bifida occulta. ( 18541973 )
2008
5
Supernumerary nipples in association with Hailey-Hailey disease in a Tunisian family. ( 18713596 )
2008
6
Supernumerary nipples and renal malformations: a family study. ( 15578130 )
2004
7
Supernumerary nipples in children with hematologic disorders. ( 15205090 )
2004
8
Supernumerary nipples: an overview. ( 12769398 )
2003
9
Supernumerary nipples a risk factor? ( 12383111 )
2002
10
Occurrence of supernumerary nipples in children with kidney and urinary tract malformations. ( 11576400 )
2001
11
Paradominant inheritance, supernumerary nipples and Becker's nevus: once again! ( 11701421 )
2001
12
Supernumerary nipple as a cutaneous marker of mitral valve prolapse in Asian Indians. ( 10980229 )
2000
13
High incidence of supernumerary nipples and twins in formosan macaques (Macaca cyclopis) at Mt. Longevity, Taiwan. ( 11132113 )
2000
14
Supernumerary nipples in a Bartsocas-Papas patient in a consanguineous Iranian family. ( 10319208 )
1999
15
Becker nevus syndrome and supernumerary nipples. ( 9557900 )
1998
16
Paget's disease versus Toker cell hyperplasia in a supernumerary nipple. ( 9532009 )
1998
17
Supernumerary nipple in association with Becker nevus vs. Becker nevus syndrome: a semantic problem only. ( 9557899 )
1998
18
Supernumerary nipples: prevalence, size, sex and side predilection -- a prospective clinical study. ( 9809822 )
1998
19
Supernumerary nipples occurring together with Becker's naevus: an association involving one common paradominant trait? ( 9272160 )
1997
20
Male to male transmission of supernumerary nipples. ( 9056560 )
1997
21
Male to male transmission of supernumerary nipples. ( 9375935 )
1997
22
Supernumerary nipples and accessory breast tissue. ( 8936016 )
1996
23
Ectopic breast tissue, supernumerary breasts, and supernumerary nipples. ( 7660204 )
1995
24
Miscellaneous genodermatoses: Beckwith-Wiedemann syndrome, Birt-Hogg-Dube syndrome, familial atypical multiple mole melanoma syndrome, hereditary tylosis, incontinentia pigmenti, and supernumerary nipples. ( 7712645 )
1995
25
Supernumerary nipples and renal anomalies. ( 8034421 )
1994
26
Familial supernumerary nipples and breasts. ( 1638072 )
1992
27
Aplasia cutis congenita associated with syndactyly and supernumerary nipples: report of a second family with similar clinical findings. ( 1650463 )
1991
28
Supernumerary nipples. ( 3044055 )
1988
29
Association of supernumerary nipples and renal anomalies. ( 3285662 )
1988
30
The prevalence of supernumerary nipples in Arab infants and children. ( 3396602 )
1988
31
Supernumerary nipples and urinary tract anomalies. ( 3346797 )
1988
32
Familial supernumerary nipples. ( 3228141 )
1988
33
Supernumerary nipples and urologic malignancies. ( 3791170 )
1987
34
Association of supernumerary nipples with renal anomalies. ( 3305849 )
1987
35
Supernumerary nipples and renal anomalies in neonates. ( 3303913 )
1987
36
High incidence of supernumerary nipples in end-stage renal failure. ( 3796781 )
1986
37
Lack of association of supernumerary nipples with renal anomalies in black infants. ( 3746542 )
1986
38
Urinary tract abnormalities in children with supernumerary nipples. ( 6691028 )
1984
39
Association of supernumerary nipples with other anomalies. ( 6848716 )
1983
40
Occurrence of supernumerary nipples in newborns. ( 6613938 )
1983
41
Clinical significance of supernumerary nipples in black neonates. ( 7056000 )
1982
42
Association of supernumerary nipples with other anomalies. ( 448569 )
1979
43
Supernumerary nipples in the baboon (Papio cynocephalus). ( 5004242 )
1971
44
Supernumerary nipples and neurosis. ( 18868187 )
1948
45
Supernumerary nipples and neurosis. ( 18870114 )
1948
46
Supernumerary nipples and neurosis. ( 18866305 )
1948
47
Supernumerary Nipples and Mammae: With an Account of Sixty-five Instances observed. ( 17231277 )
1879

Variations for Nipples, Supernumerary

Expression for Nipples, Supernumerary

Search GEO for disease gene expression data for Nipples, Supernumerary.

Pathways for Nipples, Supernumerary

GO Terms for Nipples, Supernumerary

Sources for Nipples, Supernumerary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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