Nk-Cell Enteropathy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Orphanet: ⁵⁸ Natural killer (NK)-cell enteropathy is a benign NK-cell lymphoproliferative disease characterized by minor abdominal symptoms (abdominal pain, diverticulosis, constipation and reflux) due to NK cell-derived lesions in the mucosal layer of the gastrointestinal tract and often mistaken for NK or T-cell lymphoma (see these terms).

MalaCards based summary: Nk-Cell Enteropathy is related to burkitt lymphoma and inflammatory bowel disease 1. An important gene associated with Nk-Cell Enteropathy is JAK3 (Janus Kinase 3), and among its related pathways/superpathways are Signal Transduction and NFAT and Cardiac Hypertrophy. Affiliated tissues include lymph node, and related phenotypes are edema and lymphoproliferative disorder

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Related Diseases for Nk-Cell Enteropathy

Diseases related to Nk-Cell Enteropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)

#	Related Disease	Score	Top Affiliating Genes
1	burkitt lymphoma	10.0
2	inflammatory bowel disease 1	10.0
3	helicobacter pylori infection	10.0
4	mature t-cell and nk-cell lymphoma	10.0
5	lymphoma	10.0
6	lymphoproliferative syndrome	10.0
7	nasal type extranodal nk/t-cell lymphoma	10.0
8	stomach disease	10.0
9	crohn's disease	10.0
10	pineal region meningioma	9.9	SMARCB1 PTPRS
11	cerebrovascular benign neoplasm	9.8	SMARCB1 PTPRS
12	pineal gland cancer	9.8	SMARCB1 PTPRS
13	renal cell carcinoma, papillary, 1	9.8	SMARCB1 CUL3 AXL
14	pineoblastoma	9.8	SMARCB1 PTPRS
15	papilloma of choroid plexus	9.7	SMARCB1 PTPRS
16	wilms tumor 1	9.5	SMARCB1 RUNX1T1 IGF1R CHEK2
17	autosomal dominant intellectual developmental disorder	9.5	SMARCB1 SETD5
18	medulloblastoma	9.4	SMARCB1 IGF1R ERBB4 CUL3 AURKB
19	leukemia, acute myeloid	9.3	RUNX1T1 JAK3 IGF1R CHEK2 AXL AURKB

Graphical network of the top 20 diseases related to Nk-Cell Enteropathy:

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Symptoms & Phenotypes for Nk-Cell Enteropathy

Human phenotypes related to Nk-Cell Enteropathy:

⁵⁸ ³⁰ (show all 14)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	edema ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0000969
2	lymphoproliferative disorder ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0005523
3	increased t cell count ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0100828
4	abdominal pain ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002027
5	constipation ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002019
6	gastroesophageal reflux ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002020
7	colonic diverticula ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002253
8	hematochezia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002573
9	gastric ulcer ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002592
10	duodenal ulcer ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002588
11	intestinal polyp ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0005266
12	stercoral ulcer ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0012425
13	abnormality of the gastric mucosa ⁵⁸		Occasional (29-5%)
14	diarrhea ⁵⁸		Occasional (29-5%)

GenomeRNAi Phenotypes related to Nk-Cell Enteropathy according to GeneCards Suite gene sharing:

²⁵ (show all 48)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00173-A	11.02	AURKB
2	Decreased viability	GR00221-A-1	11.02	AXL IGF1R AURKB PIK3CB SMARCB1
3	Decreased viability	GR00221-A-2	11.02	AXL IGF1R AURKB CHEK2 SMARCB1
4	Decreased viability	GR00221-A-3	11.02	IGF1R CHEK2 PIK3CB SMARCB1 JAK3
5	Decreased viability	GR00221-A-4	11.02	AXL AURKB CHEK2 PIK3CB
6	Decreased viability	GR00249-S	11.02	AURKB SMARCB1
7	Decreased viability	GR00301-A	11.02	AXL ERBB4 IGF1R
8	Decreased viability	GR00342-S-1	11.02	ERBB4
9	Decreased viability	GR00342-S-2	11.02	IGF1R CHEK2
10	Decreased viability	GR00381-A-1	11.02	PIK3CB SMARCB1
11	Decreased viability	GR00402-S-2	11.02	IGF1R PIK3CB JAK3
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-1	10.4	CHEK2
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-10	10.4	AURKB
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	10.4	JAK3
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-112	10.4	CHEK2
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-114	10.4	CHEK2
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	10.4	CHEK2
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	10.4	CHEK2
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-131	10.4	AURKB
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-134	10.4	PIK3CB
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-142	10.4	CHEK2
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	10.4	JAK3
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-153	10.4	IGF1R
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-163	10.4	AURKB
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	10.4	SMARCB1
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-194	10.4	SMARCB1
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-196	10.4	AURKB
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-20	10.4	JAK3
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-21	10.4	AURKB
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-22	10.4	PIK3CB
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-60	10.4	CHEK2 IGF1R JAK3 PIK3CB
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-68	10.4	AURKB
33	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	10.4	AXL
34	Increased shRNA abundance (Z-score > 2)	GR00366-A-75	10.4	SMARCB1
35	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	10.4	CHEK2 IGF1R JAK3 PIK3CB AURKB AXL
36	Increased shRNA abundance (Z-score > 2)	GR00366-A-95	10.4	AURKB
37	Increased shRNA abundance (Z-score > 2)	GR00366-A-96	10.4	JAK3
38	Decreased substrate adherent cell growth	GR00193-A-1	9.91	AXL IGF1R
39	Decreased substrate adherent cell growth	GR00193-A-2	9.91	AURKB
40	Decreased substrate adherent cell growth	GR00193-A-3	9.91	AXL CHEK2
41	Decreased substrate adherent cell growth	GR00193-A-4	9.91	AURKB AXL CHEK2 IGF1R
42	Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)	GR00104-A-0	9.67	AURKB AXL CUL3 PIK3CB
43	Increased cell viability after pRB stimulation	GR00230-A-1	9.33	CHEK2 ERBB4 IGF1R
44	Increased Nanog expression	GR00371-A-1	9.32	CIC SETD5
45	Increased Nanog expression	GR00371-A-2	9.32	CIC SETD5
46	Increased Nanog expression	GR00371-A-3	9.32	AURKB CIC SETD5
47	Increased Nanog expression	GR00371-A-4	9.32	SETD5
48	Increased Nanog expression	GR00371-A-5	9.32	CIC SETD5

MGI Mouse Phenotypes related to Nk-Cell Enteropathy:

⁴⁵ (show all 15)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.24	AXL CHEK2 CIC CUL3 ERBB4 IGF1R
2	growth/size/body region	MP:0005378	10.22	AURKB AXL CIC CUL3 IGF1R JAK3
3	homeostasis/metabolism	MP:0005376	10.19	AURKB AXL CHEK2 CUL3 IGF1R PIK3CB
4	cellular	MP:0005384	10.11	AURKB AXL CHEK2 CUL3 ERBB4 IGF1R
5	cardiovascular system	MP:0005385	10.1	AURKB AXL CHEK2 CUL3 ERBB4 IGF1R
6	endocrine/exocrine gland	MP:0005379	10.06	AXL CHEK2 ERBB4 IGF1R JAK3 PIK3CB
7	embryo	MP:0005380	10.03	AURKB CUL3 ERBB4 IGF1R JAK3 PIK3CB
8	muscle	MP:0005369	10	CUL3 ERBB4 IGF1R PTPRS SETD5 SMARCB1
9	liver/biliary system	MP:0005370	9.99	AXL CUL3 IGF1R PIK3CB SETD5 SMARCB1
10	neoplasm	MP:0002006	9.95	AURKB CHEK2 IGF1R PIK3CB SMARCB1
11	behavior/neurological	MP:0005386	9.91	CIC CUL3 ERBB4 IGF1R JAK3 PTPRS
12	digestive/alimentary	MP:0005381	9.88	IGF1R JAK3 PTPRS RUNX1T1 SETD5 SMARCB1
13	reproductive system	MP:0005389	9.85	AURKB AXL CHEK2 CUL3 ERBB4 IGF1R
14	mortality/aging	MP:0010768	9.77	AURKB AXL CHEK2 CIC CUL3 ERBB4
15	integument	MP:0010771	9.28	AURKB AXL ERBB4 IGF1R PIK3CB PTPRS

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Drugs & Therapeutics for Nk-Cell Enteropathy

Search Clinical Trials, NIH Clinical Center for Nk-Cell Enteropathy

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Genetic Tests for Nk-Cell Enteropathy

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Anatomical Context for Nk-Cell Enteropathy

Organs/tissues related to Nk-Cell Enteropathy:

MalaCards : Lymph Node

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Publications for Nk-Cell Enteropathy

Articles related to Nk-Cell Enteropathy:

(show all 18)

#	Title	Authors	PMID	Year
1	Indolent NK-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract - a Report of two Cases of a new Provisional Entity on the World Health Organization Classification of Hematolymphoid Tumors. ⁶²	Alves de Castro JV...Ferreira CR	35903908	2022
2	Lymphomatoid gastropathy/NK-cell enteropathy involving the stomach and intestine. ⁶²	Nakajima M...Iwao Y	35474034	2022
3	Cellular Origins and Pathogenesis of Gastrointestinal NK- and T-Cell Lymphoproliferative Disorders. ⁶²	Hue SS...Tan SY	35626087	2022
4	[Clinicopathological characteristics of natural killer cell enteropathy: report of two cases and review of literature]. ⁶²	Huo YJ...Li WC	35152628	2022
5	Natural Killer-cell Enteropathy of the Stomach in an Elderly Woman: A Case Report. ⁶²	Koo YY...Kim TO	34955512	2021
6	Diagnostic approach to T- and NK-cell lymphoproliferative disorders in the gastrointestinal tract. ⁶²	Susan SH...Tan SY	34016481	2021
7	Lymph node involvement by enteropathy-like indolent NK-cell proliferation. ⁶²	Dargent JL...de Leval L	32696224	2021
8	Natural Killer Cell Enteropathy With Extraintestinal Involvement: Presenting as Symptomatic Anemia. ⁶²	Panigrahi MK...Samal SC	34549068	2021
9	Update on lymphoproliferative disorders of the gastrointestinal tract: disease spectrum from indolent lymphoproliferations to aggressive lymphomas. ⁶²	Montes-Moreno S...Calaminici M	31773249	2020
10	An Enteropathy-like Indolent NK-Cell Proliferation Presenting in the Female Genital Tract. ⁶²	Krishnan R...Gru AA	31609783	2020
11	T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update. ⁶²	van Vliet C...Spagnolo DV	31727264	2020
12	Recurrent somatic JAK3 mutations in NK-cell enteropathy. ⁶²	Xiao W...Jaffe ES	31383643	2019
13	NK-cell enteropathy, a potential diagnostic pitfall of intestinal lymphoproliferative disease. ⁶²	Wang R...Varikatt W	30819538	2019
14	NK-Cell Enteropathy and Similar Indolent Lymphoproliferative Disorders: A Case Series With Literature Review. ⁶²	Xia D...Zukerberg LR	30212873	2019
15	NK cell enteropathy: a case report with 10 years of indolent clinical behaviour. ⁶²	Isom JA...Allan RW	29474745	2018
16	Early lymphoid lesions: conceptual, diagnostic and clinical challenges. ⁶²	Ganapathi KA...Jaffe ES	25176983	2014
17	Gastrointestinal lymphomas: Morphology, immunophenotype and molecular features. ⁶²	Bautista-Quach MA...Wang J	22943012	2012
18	NK-cell enteropathy: a benign NK-cell lymphoproliferative disease mimicking intestinal lymphoma: clinicopathologic features and follow-up in a unique case series. ⁶²	Mansoor A...Jaffe ES	20966166	2011

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Genes for Nk-Cell Enteropathy

Genes related to Nk-Cell Enteropathy (1 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	JAK3	Janus Kinase 3	Protein Coding	400	Pathogenic ⁵
2	AURKB	Aurora Kinase B	Protein Coding	25	Likely pathogenic ⁵
3	AXL	AXL Receptor Tyrosine Kinase	Protein Coding	25	Likely pathogenic ⁵
4	CHEK2	Checkpoint Kinase 2	Protein Coding	25	Likely pathogenic ⁵
5	CIC	Capicua Transcriptional Repressor	Protein Coding	25	Likely pathogenic ⁵
6	CUL3	Cullin 3	Protein Coding	25	Likely pathogenic ⁵
7	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	25	Likely pathogenic ⁵
8	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	25	Likely pathogenic ⁵
9	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	25	Likely pathogenic ⁵
10	PTPRS	Protein Tyrosine Phosphatase Receptor Type S	Protein Coding	25	Likely pathogenic ⁵
11	RUNX1T1	RUNX1 Partner Transcriptional Co-Repressor 1	Protein Coding	25	Likely pathogenic ⁵
12	SETD5	SET Domain Containing 5	Protein Coding	25	Likely pathogenic ⁵
13	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	25	Likely pathogenic ⁵

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Variations for Nk-Cell Enteropathy

ClinVar genetic disease variations for Nk-Cell Enteropathy:

⁵ (show all 13)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	JAK3	NM_000215.4(JAK3):c.1688_1696del (p.Lys563_Cys565del)	DEL	Pathogenic	638620	rs1599873586	GRCh37: 19:17948746-17948754 GRCh38: 19:17837937-17837945
2	PTPRS	NM_002850.4(PTPRS):c.4756G>A (p.Val1586Met)	SNV	Likely Pathogenic	638621	rs140472977	GRCh37: 19:5212361-5212361 GRCh38: 19:5212350-5212350
3	AURKB	NM_004217.4(AURKB):c.847C>T (p.Arg283Cys)	SNV	Likely Pathogenic	638622	rs1597343914	GRCh37: 17:8108548-8108548 GRCh38: 17:8205230-8205230
4	CUL3	NM_003590.5(CUL3):c.1499G>A (p.Gly500Asp)	SNV	Likely Pathogenic	638623	rs1574631977	GRCh37: 2:225365191-225365191 GRCh38: 2:224500474-224500474
5	CHEK2	NM_007194.4(CHEK2):c.1421G>T (p.Arg474Leu)	SNV	Likely Pathogenic	638624	rs121908706	GRCh37: 22:29090060-29090060 GRCh38: 22:28694072-28694072
6	SMARCB1	NM_003073.5(SMARCB1):c.1129C>G (p.Arg377Gly)	SNV	Likely Pathogenic	638627	rs1601446826	GRCh37: 22:24176338-24176338 GRCh38: 22:23834151-23834151
7	ERBB4	NM_005235.3(ERBB4):c.785G>A (p.Cys262Tyr)	SNV	Likely Pathogenic	638628	rs1575051224	GRCh37: 2:212587216-212587216 GRCh38: 2:211722491-211722491
8	IGF1R	NM_000875.5(IGF1R):c.3464G>A (p.Gly1155Asp)	SNV	Likely Pathogenic	638629	rs1596476061	GRCh37: 15:99486158-99486158 GRCh38: 15:98942929-98942929
9	PIK3CB	NM_006219.3(PIK3CB):c.2961G>T (p.Glu987Asp)	SNV	Likely Pathogenic	638630	rs1577033077	GRCh37: 3:138375098-138375098 GRCh38: 3:138656256-138656256
10	SETD5	NM_001080517.3(SETD5):c.2837C>T (p.Pro946Leu)	SNV	Likely Pathogenic	638631	rs936256673	GRCh37: 3:9512255-9512255 GRCh38: 3:9470571-9470571
11	AXL	NM_021913.5(AXL):c.2161C>G (p.Leu721Val)	SNV	Likely Pathogenic	638632	rs1599744167	GRCh37: 19:41762481-41762481 GRCh38: 19:41256576-41256576
12	RUNX1T1	NM_175635.3(RUNX1T1):c.127A>C (p.Thr43Pro)	SNV	Likely Pathogenic	638625	rs1587007112	GRCh37: 8:93027037-93027037 GRCh38: 8:92014809-92014809
13	CIC	NM_001386298.1(CIC):c.7506dup (p.Pro2503fs)	DUP	Likely Pathogenic	638626	rs1422380205	GRCh37: 19:42799294-42799295 GRCh38: 19:42295142-42295143

Sources

Expression for Nk-Cell Enteropathy

Search GEO for disease gene expression data for Nk-Cell Enteropathy.

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Pathways for Nk-Cell Enteropathy

Pathways related to Nk-Cell Enteropathy according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Signal Transduction ⁶⁶	12.97	PTPRS PIK3CB JAK3 IGF1R ERBB4 CUL3
2	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	12.52	PIK3CB JAK3 IGF1R ERBB4
3	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.29	PIK3CB JAK3 IGF1R ERBB4
4	Development IGF-1 receptor signaling ²² Show member pathways Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	11.9	PIK3CB JAK3 IGF1R
5	NF-kappaB Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ Apoptosis Pathway ⁷⁰	11.87	PIK3CB IGF1R ERBB4 CHEK2
6	Signaling by Receptor Tyrosine Kinases ⁶⁶	11.82	PTPRS PIK3CB JAK3 IGF1R ERBB4 AXL
7	Tyrosine Kinases / Adaptors ³	11.78	IGF1R ERBB4 AXL
8	mTOR Signaling ⁶⁵	11.72	PIK3CB IGF1R ERBB4
9	Ebola virus infection in host ⁷⁴	11.61	AXL IGF1R PIK3CB
10	Head and neck squamous cell carcinoma ⁷⁴	11.3	PIK3CB IGF1R CUL3
11	Signaling by ALK ⁶⁶ Show member pathways STAT3 nuclear events downstream of ALK signaling ⁶⁶	11.08	PIK3CB JAK3
12	FOXM1 transcription factor network ⁶¹	11.05	CHEK2 AURKB

Sources

GO Terms for Nk-Cell Enteropathy

Biological processes related to Nk-Cell Enteropathy according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell migration	GO:0016477	10.1	PIK3CB ERBB4 CUL3 AXL
2	positive regulation of protein kinase B signaling	GO:0051897	9.99	PIK3CB IGF1R AXL
3	protein autophosphorylation	GO:0046777	9.97	IGF1R ERBB4 CHEK2 AURKB
4	positive regulation of kinase activity	GO:0033674	9.95	IGF1R ERBB4 AXL
5	peptidyl-tyrosine phosphorylation	GO:0018108	9.87	AXL ERBB4 IGF1R JAK3
6	protein phosphorylation	GO:0006468	9.81	JAK3 IGF1R ERBB4 CHEK2 AXL AURKB
7	embryonic cleavage	GO:0040016	9.73	PIK3CB CUL3
8	positive regulation of cytokinesis	GO:0032467	9.73	IGF1R CUL3 AURKB
9	multicellular organism development	GO:0007275	9.63	AXL ERBB4 IGF1R
10	enzyme-linked receptor protein signaling pathway	GO:0007167	9.58	JAK3 AXL
11	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.56	PIK3CB IGF1R ERBB4 AXL
12	phosphorylation	GO:0016310	9.23	PIK3CB JAK3 IGF1R ERBB4 CHEK2 AXL

Molecular functions related to Nk-Cell Enteropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:0005524	10.3	PIK3CB JAK3 IGF1R ERBB4 CHEK2 AXL
2	nucleotide binding	GO:0000166	9.87	AURKB AXL CHEK2 ERBB4 IGF1R JAK3
3	protein tyrosine kinase activity	GO:0004713	9.86	JAK3 IGF1R ERBB4 AXL
4	transmembrane receptor protein tyrosine kinase activity	GO:0004714	9.85	IGF1R ERBB4 AXL
5	phosphatidylinositol 3-kinase binding	GO:0043548	9.73	IGF1R AXL
6	insulin receptor substrate binding	GO:0043560	9.71	PIK3CB IGF1R
7	protein kinase activity	GO:0004672	9.63	JAK3 IGF1R ERBB4 CHEK2 AXL AURKB
8	transferase activity	GO:0016740	9.56	SETD5 PIK3CB JAK3 IGF1R ERBB4 CHEK2
9	kinase activity	GO:0016301	9.23	PIK3CB JAK3 IGF1R ERBB4 CHEK2 AXL

Sources

Sources for Nk-Cell Enteropathy

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: NKC001 MIFTS: 37	Nk-Cell Enteropathy Categories: Gastrointestinal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Expand all tables

Nk-Cell Enteropathy

Aliases & Classifications for Nk-Cell Enteropathy

MalaCards integrated aliases for Nk-Cell Enteropathy:

Characteristics:

Prevelance:

Age Of Onset:

Classifications:

External Ids:

Summaries for Nk-Cell Enteropathy

Related Diseases for Nk-Cell Enteropathy

Diseases related to Nk-Cell Enteropathy via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Nk-Cell Enteropathy:

Symptoms & Phenotypes for Nk-Cell Enteropathy

Human phenotypes related to Nk-Cell Enteropathy:

GenomeRNAi Phenotypes related to Nk-Cell Enteropathy according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Nk-Cell Enteropathy:

Drugs & Therapeutics for Nk-Cell Enteropathy

Genetic Tests for Nk-Cell Enteropathy

Anatomical Context for Nk-Cell Enteropathy

Organs/tissues related to Nk-Cell Enteropathy:

Publications for Nk-Cell Enteropathy

Articles related to Nk-Cell Enteropathy:

Genes for Nk-Cell Enteropathy

Genes related to Nk-Cell Enteropathy (1 elite genes):

Variations for Nk-Cell Enteropathy

ClinVar genetic disease variations for Nk-Cell Enteropathy:

Expression for Nk-Cell Enteropathy

Pathways for Nk-Cell Enteropathy

Pathways related to Nk-Cell Enteropathy according to GeneCards Suite gene sharing:

GO Terms for Nk-Cell Enteropathy

Biological processes related to Nk-Cell Enteropathy according to GeneCards Suite gene sharing:

Molecular functions related to Nk-Cell Enteropathy according to GeneCards Suite gene sharing:

Sources for Nk-Cell Enteropathy