MCID: NCR004
MIFTS: 45

Nocardiosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Nocardiosis

MalaCards integrated aliases for Nocardiosis:

Name: Nocardiosis 12 76 53 59 3 15
Nocardia Infections 44 73
Nocardia Infection 53 3
Nocardia Infectious Disease 12
Lung Nocardiosis 53

Characteristics:

Orphanet epidemiological data:

59
nocardiosis
Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:2312
ICD10 33 A43 A43.9
MeSH 44 D009617
SNOMED-CT 68 29227009
Orphanet 59 ORPHA31204
ICD10 via Orphanet 34 A43.0 A43.1 A43.8 more
MESH via Orphanet 45 C536125
UMLS via Orphanet 74 C0028242
UMLS 73 C0028242

Summaries for Nocardiosis

NIH Rare Diseases : 53 Nocardiosis is a rare infectious disorder, that affects the brain, skin, and/or lungs. It occurs mainly in people with a weakened immune system but can affect anyone, and about one-third of infected people do not have any immune problems.. This condition usually starts in the lungs and can spread to other body organs. Affected individuals usually experience problems with their lungs (chest pain, coughing up blood, fevers), brain (headaches and seizures), and skin (skin infections, ulcers, and abscesses). Nocardiosis is caused by a bacteria of the family (genus) known as Nocardia which have different species (types). Nocardia bacteria are able to cause localized or systemic disease in humans and animals. The Nocordia bacteria are able to spread to any organ, specially the central nervous system (brain and spine), and have a tendency to recur or progress despite appropriate treatment. The nocardia bacteria are found in soil around the world. People contract this disease by either inhaling contaminated dust or if soil containing nocardia bacteria get into an open wound. People with nocardiosis may need to take multiple antibiotics given for several months�??or even up to a year or more. 

MalaCards based summary : Nocardiosis, also known as nocardia infections, is related to mycobacterium fortuitum and actinomycosis, and has symptoms including cellulitis, pneumonia and lesions in the brain or meninges. An important gene associated with Nocardiosis is IL12RB1 (Interleukin 12 Receptor Subunit Beta 1). The drugs Ritonavir and Emtricitabine have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and skin, and related phenotypes are behavior/neurological and adipose tissue

Disease Ontology : 12 An opportunistic bacterial infectious disease that results in disseminated infection in immunocompromised hosts, has material basis in Nocardia asteroides. The infection has symptom pneumonia, has symptom cellulitis, has symptom lesions in the brain or meninges, and has symptom ascending regional lymphadenopathy.

CDC : 3 Nocardiosis is a disease caused by bacteria found in soil and water. It can affect the lungs, brain, and skin.

Wikipedia : 76 Nocardiosis is an infectious disease affecting either the lungs (pulmonary nocardiosis) or the whole... more...

Related Diseases for Nocardiosis

Diseases related to Nocardiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 mycobacterium fortuitum 29.5 IL12RB1 HSPD1
2 actinomycosis 10.3
3 pulmonary tuberculosis 10.2
4 lupus erythematosus 10.2
5 systemic lupus erythematosus 10.1
6 aspergillosis 10.1
7 arthritis 10.1
8 lymphoma 10.1
9 pulmonary alveolar proteinosis 10.1
10 viral infectious disease 10.1
11 rheumatoid arthritis 10.0
12 chronic granulomatous disease 10.0
13 nephrotic syndrome 10.0
14 pneumonia 10.0
15 pemphigus vulgaris, familial 10.0
16 thrombocytopenic purpura, autoimmune 10.0
17 pulmonary disease, chronic obstructive 10.0
18 crohn's disease 10.0
19 pemphigus vulgaris 10.0
20 lymphocytic leukemia 10.0
21 sporotrichosis 10.0
22 purpura 10.0
23 pemphigus 10.0
24 leukemia, chronic lymphocytic 2 9.9
25 leukemia, chronic lymphocytic 9.9
26 lung cancer 9.9
27 leukemia 9.9
28 colitis 9.9
29 conn's syndrome 9.9
30 human immunodeficiency virus infectious disease 9.9
31 vasculitis 9.9
32 leukemia, b-cell, chronic 9.9
33 mycetoma 9.9
34 mycobacterium tuberculosis 1 9.9 IL12RB1 HSPD1
35 breast cancer 9.8
36 myositis 9.8
37 small cell cancer of the lung 9.8
38 temporal arteritis 9.8
39 cystic fibrosis 9.8
40 myeloma, multiple 9.8
41 melioidosis 9.8
42 cardiac tamponade 9.8
43 phaeohyphomycosis 9.8
44 endophthalmitis 9.8
45 acquired immunodeficiency syndrome 9.8
46 connective tissue disease 9.8
47 lung disease 9.8
48 lymphosarcoma 9.8
49 evans' syndrome 9.8
50 bronchiectasis 9.8

Graphical network of the top 20 diseases related to Nocardiosis:



Diseases related to Nocardiosis

Symptoms & Phenotypes for Nocardiosis

Symptoms:

12
  • cellulitis
  • pneumonia
  • lesions in the brain or meninges
  • ascending regional lymphadenopathy

MGI Mouse Phenotypes related to Nocardiosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 HSPD1 IL12RB1 POMC TMEM79 ZIC3
2 adipose tissue MP:0005375 9.33 IL12RB1 POMC TMEM79
3 growth/size/body region MP:0005378 9.1 HSPD1 IL12RB1 POMC TMEM79 UTF1 ZIC3

Drugs & Therapeutics for Nocardiosis

Drugs for Nocardiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
2
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
3
Nevirapine Approved Phase 4 129618-40-2 4463
4
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
5 Antiviral Agents Phase 4,Phase 3
6 Nucleic Acid Synthesis Inhibitors Phase 4
7 HIV Protease Inhibitors Phase 4,Phase 3
8 Anti-HIV Agents Phase 4,Phase 3
9 Cytochrome P-450 CYP3A Inducers Phase 4
10 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2
12 Atazanavir Sulfate Phase 4
13 Reverse Transcriptase Inhibitors Phase 4
14 Anti-Retroviral Agents Phase 4,Phase 3
15 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2
16
protease inhibitors Phase 4,Phase 3
17 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
18
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
19 tannic acid Approved Phase 3
20
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
21
Efavirenz Approved, Investigational Phase 3 154598-52-4 64139
22
Maraviroc Approved, Investigational Phase 3 376348-65-1 3002977
23
Fosamprenavir Approved Phase 3 226700-79-4 131536
24 Peripheral Nervous System Agents Phase 3
25 Analgesics Phase 3
26 Interleukin-2 Phase 3
27 Analgesics, Non-Narcotic Phase 3
28
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
29
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
30 Hormones Phase 2
31 Steroid Synthesis Inhibitors Phase 2
32
Hydroxyitraconazole Phase 2
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
34 Hormone Antagonists Phase 2
35 Antifungal Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
2 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
3 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
4 Immuno-stimulation With Maraviroc Combined to Antiretroviral Therapy in Advanced Late Diagnosed HIV-1 Infected Patients Completed NCT01348308 Phase 3 Maraviroc (Celsentri);Placebo
5 Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan Recruiting NCT03086226 Phase 2 Fosravuconazole;Itraconazole

Search NIH Clinical Center for Nocardiosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: nocardia infections

Genetic Tests for Nocardiosis

Anatomical Context for Nocardiosis

MalaCards organs/tissues related to Nocardiosis:

41
Lung, Brain, Skin, Bone, Bone Marrow, Kidney, Thyroid

Publications for Nocardiosis

Articles related to Nocardiosis:

(show top 50) (show all 880)
# Title Authors Year
1
A case of Aspergillus and Nocardia infections after bronchial thermoplasty. ( 30519471 )
2019
2
Fulminant Nocardiosis Due to a Multidrug-Resistant Isolate in a 12-Year-Old Immunocompetent Child. ( 29386239 )
2018
3
Menace Elbow: Disseminated Nocardiosis. ( 29729234 )
2018
4
Unmasking of poorly controlled diabetes mellitus by pulmonary nocardiosis. ( 29776946 )
2018
5
Cutaneous nocardiosis by a new pathogenic species: <i>Nocardia grenadensis</i>. ( 29866698 )
2018
6
A 20-year experience with nocardiosis in solid organ transplant (SOT) recipients in the Southwestern United States: A single-center study. ( 29668074 )
2018
7
Pulmonary Nocardiosis and Scrub Typhus in an Immunocompromised Host. ( 29910572 )
2018
8
Nocardiosis from 1888 to 2017. ( 29146497 )
2018
9
Pulmonary Nocardiosis: Unusual Presentation in Intensive Care Unit. ( 29531457 )
2018
10
Ventilator-dependent pulmonary nocardiosis in a patient with chronic obstructive pulmonary disease. ( 29319037 )
2018
11
Current knowledge of nocardiosis in teleost fish. ( 29341219 )
2018
12
Relationship between the duration of trimethoprim/sulfamethoxazole treatment and the clinical outcome of pulmonary nocardiosis. ( 29548655 )
2018
13
Comment on a Primary Cutaneous <i>Nocardiosis</i> of the Hand. ( 29484029 )
2018
14
Clinical Assessment of a Nocardia PCR-Based Assay for Diagnosis of Nocardiosis. ( 29563199 )
2018
15
Disseminated nocardiosis caused by Nocardia elegans: a case report and review of the literature. ( 29737456 )
2018
16
Nocardiosis incognito: Primary cutaneous nocardiosis with extension to myositis and pleural infection. ( 29296648 )
2018
17
Systemic nocardiosis in a lepromatous leprosy patient with type 2 reaction. ( 29520868 )
2018
18
Role of FNA and Special Stains in Rapid Cytopathological Diagnosis of Pulmonary Nocardiosis. ( 29669313 )
2018
19
Successful Treatment of Disseminated Nocardiosis Caused by Nocardia veterana in a Dog. ( 29105868 )
2018
20
Aspergillosis, nocardiosis and scleroderma, a fatal and infrequent association. ( 29983162 )
2018
21
Disseminated Nocardiosis with retinal abscess in a patient treated for bullous pemphigoid. ( 29780924 )
2018
22
Nocardiosis in a patient with anti-PD-1-associated colitis treated with infliximab. ( 30017385 )
2018
23
Disseminated nocardiosis with infective endocarditis of a transplanted heart. ( 30317192 )
2018
24
Disseminated Nocardiosis with subretinal abscess in a patient with nephrotic syndrome-a case report. ( 30176830 )
2018
25
Pulmonary nocardiosis mimicking small cell lung cancer in ectopic ACTH syndrome associated with transformation of olfactory neuroblastoma: a case report. ( 30134888 )
2018
26
Pulmonary nocardiosis in a patient with idiopathic CD4 T-lymphocytopenia. ( 29321927 )
2018
27
High Intraspecific Genetic Diversity of Nocardia brasiliensis, a Pathogen Responsible for Cutaneous Nocardiosis Found in France: Phylogenetic Relationships by Using sod and hsp65 Genes. ( 29888277 )
2018
28
Pulmonary nocardiosis masquerading renascence of tuberculosis in an immunocompetent host: a case report from Nepal. ( 30016976 )
2018
29
Correction to: Pulmonary nocardiosis masquerading renascence of tuberculosis in an immunocompetent host: a case report from Nepal. ( 30045768 )
2018
30
NOCARDIOSIS: 7-YEAR experience at an australian tertiary hospital. ( 30091232 )
2018
31
Ocular Nocardiosis: A Case Report. ( 30095316 )
2018
32
Nocardiosis in Sudan: Current Situation and Future Perspective. ( 30207249 )
2018
33
Disseminated Nocardiosis Initially Manifesting as Visual Field Defects. ( 30210132 )
2018
34
An unusual successful treatment with non-sulfonamides: primary cutaneous nocardiosis caused by Nocardia brasiliensis. ( 30237721 )
2018
35
Disseminated nocardiosis with cerebral and subcutaneous lesions on low-dose prednisone. ( 30242096 )
2018
36
Primary cutaneous nocardiosis: a diagnosis of consideration in a renal transplant recipient. ( 30302055 )
2018
37
Two cases of primary cutaneous nocardiosis caused by intralesional injection. ( 30365211 )
2018
38
Lymphocutaneous nocardiosis in a kidney transplant patient successfully treated with tigecycline. ( 30381521 )
2018
39
Retrospective analysis of nocardiosis in a general hospital from 1998 to 2017. ( 30401464 )
2018
40
Nocardia infections in the transplanted host. ( 29668123 )
2018
41
Microbiological and clinical data analysis of 32 patients with Nocardia infections in Yantai ( 29714454 )
2018
42
Manifestations and outcomes of nocardia infections: Comparison of immunocompromised and nonimmunocompromised adult patients. ( 30290600 )
2018
43
Primary Cutaneous Nocardiosis in an Immunocompetent Patient. ( 28202876 )
2017
44
Nocardiosis in south of France during the last ten years. ( 28088585 )
2017
45
Nocardiosis in freshwater reared Chinook salmon (Oncorhynchus tshawytscha). ( 28372487 )
2017
46
Disseminated nocardiosis in a liver transplant patient. ( 29240499 )
2017
47
Primary Cutaneous Nocardiosis Caused by Nocardia takedensis. ( 28761296 )
2017
48
Primary cutaneous nocardiosis caused by Nocardia brasiliensis following a wasp sting. ( 28397286 )
2017
49
Pleural Nocardiosis in Immunocompetent Patient. ( 28292374 )
2017
50
Successful treatment of pulmonary nocardiosis with fluoroquinolone in bronchial asthma and bronchiectasis. ( 28352469 )
2017

Variations for Nocardiosis

Expression for Nocardiosis

Search GEO for disease gene expression data for Nocardiosis.

Pathways for Nocardiosis

GO Terms for Nocardiosis

Cellular components related to Nocardiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.62 HSPD1 POMC

Biological processes related to Nocardiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interferon-gamma production GO:0032729 8.62 HSPD1 IL12RB1

Sources for Nocardiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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