MCID: NCR004
MIFTS: 44

Nocardiosis

Categories: Rare diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Nocardiosis

MalaCards integrated aliases for Nocardiosis:

Name: Nocardiosis 12 76 53 59 3 15
Nocardia Infections 44 73
Nocardia Infection 53 3
Nocardia Infectious Disease 12
Lung Nocardiosis 53

Characteristics:

Orphanet epidemiological data:

59
nocardiosis
Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:2312
ICD10 33 A43 A43.9
MeSH 44 D009617
Orphanet 59 ORPHA31204
ICD10 via Orphanet 34 A43.0 A43.1 A43.8 more
MESH via Orphanet 45 C536125
UMLS via Orphanet 74 C0028242
UMLS 73 C0028242

Summaries for Nocardiosis

NIH Rare Diseases : 53 Nocardiosis is a rare infectious disorder, that affects the brain, skin, and/or lungs. It occurs mainly in people with a weakened immune system but can affect anyone, and about one-third of infected people do not have any immune problems.. This condition usually starts in the lungs and can spread to other body organs. Affected individuals usually experience problems with their lungs (chest pain, coughing up blood, fevers), brain (headaches and seizures), and skin (skin infections, ulcers, and abscesses). Nocardiosis is caused by a bacteria of the family (genus) known as Nocardia which have different species (types). Nocardia bacteria are able to cause localized or systemic disease in humans and animals. The Nocordia bacteria are able to spread to any organ, specially the central nervous system (brain and spine), and have a tendency to recur or progress despite appropriate treatment. The nocardia bacteria are found in soil around the world. People contract this disease by either inhaling contaminated dust or if soil containing nocardia bacteria get into an open wound. People with nocardiosis may need to take multiple antibiotics given for several months—or even up to a year or more. 

MalaCards based summary : Nocardiosis, also known as nocardia infections, is related to mycobacterium fortuitum and cerebritis, and has symptoms including pneumonia, cellulitis and lesions in the brain or meninges. An important gene associated with Nocardiosis is IL12RB1 (Interleukin 12 Receptor Subunit Beta 1). The drugs Emtricitabine and Nevirapine have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and skin, and related phenotype is growth/size/body region.

Disease Ontology : 12 An opportunistic bacterial infectious disease that results in disseminated infection in immunocompromised hosts, has material basis in Nocardia asteroides. The infection has symptom pneumonia, has symptom cellulitis, has symptom lesions in the brain or meninges, and has symptom ascending regional lymphadenopathy.

CDC : 3 Nocardiosis is a disease caused by bacteria found in soil and water. It can affect the lungs, brain, and skin.

Wikipedia : 76 Nocardiosis is an infectious disease affecting either the lungs (pulmonary nocardiosis) or the whole... more...

Related Diseases for Nocardiosis

Graphical network of the top 20 diseases related to Nocardiosis:



Diseases related to Nocardiosis

Symptoms & Phenotypes for Nocardiosis

Symptoms:

12
  • pneumonia
  • cellulitis
  • lesions in the brain or meninges
  • ascending regional lymphadenopathy

MGI Mouse Phenotypes related to Nocardiosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.02 HSPD1 IL12RB1 TMEM79 UTF1 ZIC3

Drugs & Therapeutics for Nocardiosis

Drugs for Nocardiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
2
Nevirapine Approved Phase 4 129618-40-2 4463
3
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
4 Anti-HIV Agents Phase 4,Phase 3
5 Anti-Infective Agents Phase 4,Phase 3,Phase 2
6 Anti-Retroviral Agents Phase 4,Phase 3
7 Antiviral Agents Phase 4,Phase 3
8 Atazanavir Sulfate Phase 4
9 Cytochrome P-450 CYP3A Inducers Phase 4
10 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2
11 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
12 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
13 HIV Protease Inhibitors Phase 4,Phase 3
14 Nucleic Acid Synthesis Inhibitors Phase 4
15
protease inhibitors Phase 4,Phase 3
16 Reverse Transcriptase Inhibitors Phase 4
17
Tenofovir Phase 4 147127-20-6 464205
18
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
19
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
20
Efavirenz Approved, Investigational Phase 3 154598-52-4 64139
21
Fosamprenavir Approved Phase 3 226700-79-4 131536
22
Maraviroc Approved, Investigational Phase 3 376348-65-1 3002977
23 tannic acid Approved, Nutraceutical Phase 3
24 Analgesics Phase 3
25 Analgesics, Non-Narcotic Phase 3
26 Interleukin-2 Phase 3
27 Peripheral Nervous System Agents Phase 3
28
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
29
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
30 Antifungal Agents Phase 2
31 Hormone Antagonists Phase 2
32 Hormones Phase 2
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
34
Hydroxyitraconazole Phase 2
35 Steroid Synthesis Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
2 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
3 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
4 Immuno-stimulation With Maraviroc Combined to Antiretroviral Therapy in Advanced Late Diagnosed HIV-1 Infected Patients Completed NCT01348308 Phase 3 Maraviroc (Celsentri);Placebo
5 Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan Recruiting NCT03086226 Phase 2 Fosravuconazole;Itraconazole

Search NIH Clinical Center for Nocardiosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: nocardia infections

Genetic Tests for Nocardiosis

Anatomical Context for Nocardiosis

MalaCards organs/tissues related to Nocardiosis:

41
Lung, Brain, Skin, Bone Marrow, Bone, Kidney, Heart

Publications for Nocardiosis

Articles related to Nocardiosis:

(show top 50) (show all 635)
# Title Authors Year
1
Fulminant Nocardiosis Due to a Multidrug-Resistant Isolate in a 12-Year-Old Immunocompetent Child. ( 29386239 )
2018
2
Menace Elbow: Disseminated Nocardiosis. ( 29729234 )
2018
3
Unmasking of poorly controlled diabetes mellitus by pulmonary nocardiosis. ( 29776946 )
2018
4
Cutaneous nocardiosis by a new pathogenic species: <i>Nocardia grenadensis</i>. ( 29866698 )
2018
5
A 20-year experience with nocardiosis in solid organ transplant (SOT) recipients in the Southwestern United States: A single-center study. ( 29668074 )
2018
6
Pulmonary Nocardiosis and Scrub Typhus in an Immunocompromised Host. ( 29910572 )
2018
7
Nocardiosis from 1888 to 2017. ( 29146497 )
2018
8
Pulmonary Nocardiosis: Unusual Presentation in Intensive Care Unit. ( 29531457 )
2018
9
Ventilator-dependent pulmonary nocardiosis in a patient with chronic obstructive pulmonary disease. ( 29319037 )
2018
10
Current knowledge of nocardiosis in teleost fish. ( 29341219 )
2018
11
Relationship between the duration of trimethoprim/sulfamethoxazole treatment and the clinical outcome of pulmonary nocardiosis. ( 29548655 )
2018
12
Comment on a Primary Cutaneous <i>Nocardiosis</i> of the Hand. ( 29484029 )
2018
13
Clinical Assessment of a Nocardia PCR-Based Assay for Diagnosis of Nocardiosis. ( 29563199 )
2018
14
Disseminated nocardiosis caused by Nocardia elegans: a case report and review of the literature. ( 29737456 )
2018
15
Nocardiosis incognito: Primary cutaneous nocardiosis with extension to myositis and pleural infection. ( 29296648 )
2018
16
Systemic nocardiosis in a lepromatous leprosy patient with type 2 reaction. ( 29520868 )
2018
17
Role of FNA and Special Stains in Rapid Cytopathological Diagnosis of Pulmonary Nocardiosis. ( 29669313 )
2018
18
Successful Treatment of Disseminated Nocardiosis Caused by Nocardia veterana in a Dog. ( 29105868 )
2018
19
Pulmonary nocardiosis in a patient with idiopathic CD4 T-lymphocytopenia. ( 29321927 )
2018
20
High Intraspecific Genetic Diversity of <i>Nocardia brasiliensis</i>, a Pathogen Responsible for Cutaneous Nocardiosis Found in France: Phylogenetic Relationships by Using <i>sod</i> and <i>hsp65</i> Genes. ( 29888277 )
2018
21
Disseminated Nocardiosis with retinal abscess in a patient treated for bullous pemphigoid. ( 29780924 )
2018
22
Brain abscess due to Nocardia infection in an immunocompetent patient with asymptomatic pulmonary alveolar proteinosis. ( 28718013 )
2017
23
Primary Cutaneous Nocardiosis in an Immunocompetent Patient. ( 28202876 )
2017
24
Nocardiosis in south of France during the last ten years. ( 28088585 )
2017
25
Nocardiosis in freshwater reared Chinook salmon (Oncorhynchus tshawytscha). ( 28372487 )
2017
26
Disseminated nocardiosis in a liver transplant patient. ( 29240499 )
2017
27
Primary Cutaneous Nocardiosis Caused by Nocardia takedensis. ( 28761296 )
2017
28
Primary cutaneous nocardiosis caused by Nocardia brasiliensis following a wasp sting. ( 28397286 )
2017
29
Pleural Nocardiosis in Immunocompetent Patient. ( 28292374 )
2017
30
Successful treatment of pulmonary nocardiosis with fluoroquinolone in bronchial asthma and bronchiectasis. ( 28352469 )
2017
31
Disseminated Nocardiosis in renal transplant recipient under therapy for pulmonary tuberculosis: a case report. ( 28159010 )
2017
32
Primary Cutaneous Nocardiosis in a Patient Taking Adalimumab Therapy for Crohn's Disease. ( 29472961 )
2017
33
Pulmonary Nocardiosis: A Clinical Analysis of 30 Cases. ( 28626172 )
2017
34
Disseminated nocardiosis complicated by multiple brain abscesses and pleural empyema in a young diabetic man: a case report. ( 29154371 )
2017
35
Syndrome of Inappropriate Antidiuretic Hormone Secretion Complicating Systemic Nocardiosis in a Renal Transplant Recipient: A Case Report. ( 29198680 )
2017
36
Cutaneous nocardiosis manifesting as a frontal mass in a patient with giant cell arteritis. ( 28559710 )
2017
37
A Primary Cutaneous Nocardiosis of the Hand. ( 28785335 )
2017
38
A Novel Case of Pulmonary Nocardiosis with Secondary Hemophagocytic Lymphohistiocytosis. ( 28836562 )
2017
39
Disseminated nocardiosis associated with the isolation of Nocardia nova in a longsnout seahorse Hippocampus reidi (Ginsburg). ( 28084628 )
2017
40
Primary cutaneous nocardiosis: a pitfall in the diagnosis of skin infection. ( 28573414 )
2017
41
Reply to comments on &amp;quot;Brain abscess due to Nocardia infection in an immunocompetent patient with asymptomatic pulmonary alveolar proteinosis&amp;quot;. Acta Neurol Belg DOI 10.1007/s13760-017-0815-6. ( 29159574 )
2017
42
Disseminated Nocardiosis Associated with Treatment with Infliximab in a Patient with Ulcerative Colitis. ( 29263313 )
2017
43
Image Gallery: Acute primary cutaneous nocardiosis due to Nocardia brasiliensis. ( 28504394 )
2017
44
Adjuvant effect of recombinant interleukin-12 in the Nocardiosis formalin-killed vaccine of the amberjack Seriola dumerili. ( 28602739 )
2017
45
Disseminated cutaneous nocardiosis with ocular involvement. ( 28500674 )
2017
46
CT findings of pulmonary nocardiosis: a report of 9 cases. ( 29268550 )
2017
47
Rare Multidrug-Resistant Pulmonary Nocardiosis in AIDS. ( 29344434 )
2017
48
Analysis of the complete genome sequence of Nocardia seriolae UTF1, the causative agent of fish nocardiosis: The first reference genome sequence of the fish pathogenic Nocardia species. ( 28257489 )
2017
49
Outcome and Treatment of Nocardiosis After Solid Organ Transplantation: New Insights From a European Study. ( 28329348 )
2017
50
Myelosuppression-sparing treatment of central nervous system nocardiosis in a multiple myeloma patient utilizing a tedizolid-based regimen: a case report. ( 28189735 )
2017

Variations for Nocardiosis

Expression for Nocardiosis

Search GEO for disease gene expression data for Nocardiosis.

Pathways for Nocardiosis

GO Terms for Nocardiosis

Biological processes related to Nocardiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interferon-gamma production GO:0032729 8.62 HSPD1 IL12RB1

Sources for Nocardiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....