MCID: NCR004
MIFTS: 44

Nocardiosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Nocardiosis

MalaCards integrated aliases for Nocardiosis:

Name: Nocardiosis 12 77 54 60 3 15 17
Nocardia Infections 45 74
Nocardia Infection 54 3
Nocardia Infectious Disease 12
Lung Nocardiosis 54

Characteristics:

Orphanet epidemiological data:

60
nocardiosis
Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:2312
MeSH 45 D009617
SNOMED-CT 69 29227009
ICD10 34 A43 A43.9
MESH via Orphanet 46 C536125
ICD10 via Orphanet 35 A43.0 A43.1 A43.8 more
UMLS via Orphanet 75 C0028242
Orphanet 60 ORPHA31204
UMLS 74 C0028242

Summaries for Nocardiosis

NIH Rare Diseases : 54 Nocardiosis is a rare infectious disorder, that affects the brain, skin, and/or lungs. It occurs mainly in people with a weakened immune system but can affect anyone, and about one-third of infected people do not have any immune problems.. This condition usually starts in the lungs and can spread to other body organs. Affected individuals usually experience problems with their lungs (chest pain, coughing up blood, fevers), brain (headaches and seizures), and skin (skin infections, ulcers, and abscesses). Nocardiosis is caused by a bacteria of the family (genus) known as Nocardia which have different species (types). Nocardia bacteria are able to cause localized or systemic disease in humans and animals. The Nocordia bacteria are able to spread to any organ, specially the central nervous system (brain and spine), and have a tendency to recur or progress despite appropriate treatment. The nocardia bacteria are found in soil around the world. People contract this disease by either inhaling contaminated dust or if soil containing nocardia bacteria get into an open wound. People with nocardiosis may need to take multiple antibiotics given for several months�??or even up to a year or more. 

MalaCards based summary : Nocardiosis, also known as nocardia infections, is related to mycobacterium fortuitum and mycobacterium tuberculosis 1, and has symptoms including cellulitis, pneumonia and lesions in the brain or meninges. An important gene associated with Nocardiosis is IL12RB1 (Interleukin 12 Receptor Subunit Beta 1). The drugs Emtricitabine and Ritonavir have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and lung.

Disease Ontology : 12 An opportunistic bacterial infectious disease that results in disseminated infection in immunocompromised hosts, has material basis in Nocardia asteroides. The infection has symptom pneumonia, has symptom cellulitis, has symptom lesions in the brain or meninges, and has symptom ascending regional lymphadenopathy.

CDC : 3 Nocardiosis is a disease caused by bacteria found in soil and water. It can affect the lungs, brain, and skin.

Wikipedia : 77 Nocardiosis is an infectious disease affecting either the lungs (pulmonary nocardiosis) or the whole... more...

Related Diseases for Nocardiosis

Diseases related to Nocardiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 mycobacterium fortuitum 29.7 HSPD1 IL12RB1
2 mycobacterium tuberculosis 1 29.4 HSPD1 IL12RB1
3 actinomycosis 10.3
4 pulmonary tuberculosis 10.2
5 systemic lupus erythematosus 10.2
6 lupus erythematosus 10.2
7 aspergillosis 10.2
8 arthritis 10.2
9 lymphoma 10.1
10 rheumatoid arthritis 10.1
11 pulmonary alveolar proteinosis 10.1
12 chronic granulomatous disease 10.1
13 leukemia 10.1
14 nephrotic syndrome 10.1
15 pneumonia 10.1
16 pemphigus vulgaris, familial 10.0
17 thrombocytopenic purpura, autoimmune 10.0
18 lung cancer 10.0
19 pulmonary disease, chronic obstructive 10.0
20 crohn's disease 10.0
21 pemphigus vulgaris 10.0
22 lymphocytic leukemia 10.0
23 sporotrichosis 10.0
24 purpura 10.0
25 pemphigus 10.0
26 mycetoma 10.0
27 leukemia, chronic lymphocytic 2 10.0
28 leukemia, chronic lymphocytic 10.0
29 colitis 10.0
30 conn's syndrome 10.0
31 pleural empyema 10.0
32 human immunodeficiency virus infectious disease 10.0
33 vasculitis 10.0
34 bronchiectasis 10.0
35 leukemia, b-cell, chronic 10.0
36 pericardial tuberculosis 9.9 CABIN1 POMC
37 breast cancer 9.9
38 myositis 9.9
39 sarcoidosis 1 9.9
40 small cell cancer of the lung 9.9
41 cystic fibrosis 9.9
42 myeloma, multiple 9.9
43 melioidosis 9.9
44 cardiac tamponade 9.9
45 phaeohyphomycosis 9.9
46 endophthalmitis 9.9
47 acquired immunodeficiency syndrome 9.9
48 connective tissue disease 9.9
49 mucormycosis 9.9
50 lung disease 9.9

Graphical network of the top 20 diseases related to Nocardiosis:



Diseases related to Nocardiosis

Symptoms & Phenotypes for Nocardiosis

Symptoms:

12
  • cellulitis
  • pneumonia
  • lesions in the brain or meninges
  • ascending regional lymphadenopathy

Drugs & Therapeutics for Nocardiosis

Drugs for Nocardiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
2
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
3
Tenofovir Approved, Experimental, Investigational Phase 4 147127-20-6 464205
4
Nevirapine Approved Phase 4 129618-40-2 4463
5 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
6 Antiviral Agents Phase 4,Phase 3
7 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2
8 HIV Protease Inhibitors Phase 4,Phase 3
9
protease inhibitors Phase 4,Phase 3
10 Anti-Infective Agents Phase 4,Phase 3,Phase 2
11 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
12 Nucleic Acid Synthesis Inhibitors Phase 4
13 Cytochrome P-450 CYP3A Inducers Phase 4
14 Anti-Retroviral Agents Phase 4,Phase 3
15 Reverse Transcriptase Inhibitors Phase 4
16 Atazanavir Sulfate Phase 4
17 Anti-HIV Agents Phase 4,Phase 3
18
Aldesleukin Approved Phase 3 110942-02-4, 85898-30-2
19
tannic acid Approved Phase 3 1401-55-4
20
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
21
Fosamprenavir Approved Phase 3 226700-79-4 131536
22
Maraviroc Approved, Investigational Phase 3 376348-65-1 3002977
23
Efavirenz Approved, Investigational Phase 3 154598-52-4 64139
24 Analgesics, Non-Narcotic Phase 3
25 Interleukin-2 Phase 3
26 Analgesics Phase 3
27 Peripheral Nervous System Agents Phase 3
28
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
29
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
30
Hydroxyitraconazole Phase 2
31 Steroid Synthesis Inhibitors Phase 2
32 Hormones Phase 2
33 Hormone Antagonists Phase 2
34 Antifungal Agents Phase 2
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
2 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
3 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
4 Immuno-stimulation With Maraviroc Combined to Antiretroviral Therapy in Advanced Late Diagnosed HIV-1 Infected Patients Completed NCT01348308 Phase 3 Maraviroc (Celsentri);Placebo
5 Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan Recruiting NCT03086226 Phase 2 Fosravuconazole;Itraconazole

Search NIH Clinical Center for Nocardiosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: nocardia infections

Genetic Tests for Nocardiosis

Anatomical Context for Nocardiosis

MalaCards organs/tissues related to Nocardiosis:

42
Brain, Skin, Lung, Bone, Bone Marrow, Prostate, Kidney

Publications for Nocardiosis

Articles related to Nocardiosis:

(show top 50) (show all 892)
# Title Authors Year
1
Disseminated nocardiosis with Nocardia brasiliensis bacteremia in a patient with rheumatoid arthritis using tocilizumab. ( 30852105 )
2019
2
Aspergillosis, nocardiosis and scleroderma, a fatal and infrequent association. ( 29983162 )
2019
3
Imaging Findings of Pulmonary Nocardiosis Mimicking Bronchiectasis. ( 30823959 )
2019
4
Pulmonary Nocardiosis Caused by Nocardia exalbida in a Patient with Lung Cancer and Radiation Pneumonitis: A Case Report and Literature Review. ( 30713323 )
2019
5
Nocardiosis: 7-year experience at an Australian tertiary hospital. ( 30091232 )
2019
6
Disseminated Nocardiosis Initially Manifesting as Visual Field Defects. ( 30210132 )
2019
7
Disseminated nocardiosis with cerebral and subcutaneous lesions on low-dose prednisone. ( 30242096 )
2019
8
Two cases of primary cutaneous nocardiosis caused by intralesional injection. ( 30365211 )
2019
9
Pulmonary nocardiosis in Western Europe-Clinical evaluation of 43 patients and population-based estimates of hospitalization rates. ( 30658169 )
2019
10
Pulmonary nocardiosis: Report of two cases from a tertiary care hospital. ( 30706884 )
2019
11
Disseminated nocardiosis secondary to Nocardia otitidiscaviarum infection with fatal outcome. ( 30850171 )
2019
12
Primary cutaneous nocardiosis. ( 30883034 )
2019
13
Isolated abdominal nocardiosis in a pediatric renal transplant recipient. ( 30888108 )
2019
14
Adult cervicofacial nocardiosis in the setting of IL-12/23 blockade. ( 30945266 )
2019
15
Nontuberculous mycobacterial and Nocardia infections mimicking pulmonary tuberculosis: a retrospective study of a general hospital patient population in China. ( 31021740 )
2019
16
A case of Aspergillus and Nocardia infections after bronchial thermoplasty. ( 30519471 )
2019
17
Nocardia Infections in Solid Organ Transplantation: Guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation. ( 30817024 )
2019
18
Disseminated Nocardiosis with retinal abscess in a patient treated for bullous pemphigoid. ( 29780924 )
2018
19
Nocardiosis in a patient with anti-PD-1-associated colitis treated with infliximab. ( 30017385 )
2018
20
Disseminated nocardiosis with infective endocarditis of a transplanted heart. ( 30317192 )
2018
21
Systemic nocardiosis in a lepromatous leprosy patient with type 2 reaction. ( 29520868 )
2018
22
Mycetoma in Timor-Leste and first report of nocardiosis. ( 30662693 )
2018
23
Nocardiosis incognito: Primary cutaneous nocardiosis with extension to myositis and pleural infection. ( 29296648 )
2018
24
Disseminated Nocardiosis with subretinal abscess in a patient with nephrotic syndrome-a case report. ( 30176830 )
2018
25
Successful Treatment of Disseminated Nocardiosis Caused by Nocardia veterana in a Dog. ( 29105868 )
2018
26
Nocardiosis from 1888 to 2017. ( 29146497 )
2018
27
Ventilator-dependent pulmonary nocardiosis in a patient with chronic obstructive pulmonary disease. ( 29319037 )
2018
28
Pulmonary nocardiosis in a patient with idiopathic CD4 T-lymphocytopenia. ( 29321927 )
2018
29
Current knowledge of nocardiosis in teleost fish. ( 29341219 )
2018
30
Fulminant Nocardiosis Due to a Multidrug-Resistant Isolate in a 12-Year-Old Immunocompetent Child. ( 29386239 )
2018
31
Comment on a Primary Cutaneous Nocardiosis of the Hand. ( 29484029 )
2018
32
Pulmonary Nocardiosis: Unusual Presentation in Intensive Care Unit. ( 29531457 )
2018
33
Relationship between the duration of trimethoprim/sulfamethoxazole treatment and the clinical outcome of pulmonary nocardiosis. ( 29548655 )
2018
34
Clinical Assessment of a Nocardia PCR-Based Assay for Diagnosis of Nocardiosis. ( 29563199 )
2018
35
A 20-year experience with nocardiosis in solid organ transplant (SOT) recipients in the Southwestern United States: A single-center study. ( 29668074 )
2018
36
Role of FNA and Special Stains in Rapid Cytopathological Diagnosis of Pulmonary Nocardiosis. ( 29669313 )
2018
37
Menace Elbow: Disseminated Nocardiosis. ( 29729234 )
2018
38
Disseminated nocardiosis caused by Nocardia elegans: a case report and review of the literature. ( 29737456 )
2018
39
Unmasking of poorly controlled diabetes mellitus by pulmonary nocardiosis. ( 29776946 )
2018
40
Cutaneous nocardiosis by a new pathogenic species: Nocardia grenadensis. ( 29866698 )
2018
41
High Intraspecific Genetic Diversity of Nocardia brasiliensis, a Pathogen Responsible for Cutaneous Nocardiosis Found in France: Phylogenetic Relationships by Using sod and hsp65 Genes. ( 29888277 )
2018
42
Pulmonary Nocardiosis and Scrub Typhus in an Immunocompromised Host. ( 29910572 )
2018
43
Pulmonary nocardiosis masquerading renascence of tuberculosis in an immunocompetent host: a case report from Nepal. ( 30016976 )
2018
44
Correction to: Pulmonary nocardiosis masquerading renascence of tuberculosis in an immunocompetent host: a case report from Nepal. ( 30045768 )
2018
45
Ocular Nocardiosis: A Case Report. ( 30095316 )
2018
46
Pulmonary nocardiosis mimicking small cell lung cancer in ectopic ACTH syndrome associated with transformation of olfactory neuroblastoma: a case report. ( 30134888 )
2018
47
Nocardiosis in Sudan: Current Situation and Future Perspective. ( 30207249 )
2018
48
An unusual successful treatment with non-sulfonamides: primary cutaneous nocardiosis caused by Nocardia brasiliensis. ( 30237721 )
2018
49
Primary cutaneous nocardiosis: a diagnosis of consideration in a renal transplant recipient. ( 30302055 )
2018
50
Lymphocutaneous nocardiosis in a kidney transplant patient successfully treated with tigecycline. ( 30381521 )
2018

Variations for Nocardiosis

Expression for Nocardiosis

Search GEO for disease gene expression data for Nocardiosis.

Pathways for Nocardiosis

GO Terms for Nocardiosis

Cellular components related to Nocardiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.62 HSPD1 POMC

Biological processes related to Nocardiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interferon-gamma production GO:0032729 8.62 HSPD1 IL12RB1

Sources for Nocardiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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