MCID: NCR004
MIFTS: 52

Nocardiosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Nocardiosis

MalaCards integrated aliases for Nocardiosis:

Name: Nocardiosis 12 73 20 58 3 15 17 32
Nocardia Infections 44 70
Nocardia Infectious Disease 12
Nocardia Infection 20
Lung Nocardiosis 20

Characteristics:

Orphanet epidemiological data:

58
nocardiosis
Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Nocardiosis

GARD : 20 Nocardiosis is a rare infectious disorder, that affects the brain, skin, and/or lungs. It occurs mainly in people with a weakened immune system but can affect anyone, and about one-third of infected people do not have any immune problems. . This condition usually starts in the lungs and can spread to other body organs. Affected individuals usually experience problems with their lungs (chest pain, coughing up blood, fevers), brain (headaches and seizures ), and skin (skin infections, ulcers, and abscesses ). Nocardiosis is caused by a bacteria of the family ( genus) known as Nocardia which have different species (types). Nocardia bacteria are able to cause localized or systemic disease in humans and animals. The Nocordia bacteria are able to spread to any organ, specially the central nervous system (brain and spine), and have a tendency to recur or progress despite appropriate treatment. The nocardia bacteria are found in soil around the world. People contract this disease by either inhaling contaminated dust or if soil containing nocardia bacteria get into an open wound. People with nocardiosis may need to take multiple antibiotics given for several months-or even up to a year or more.

MalaCards based summary : Nocardiosis, also known as nocardia infections, is related to actinomycosis and pleural empyema, and has symptoms including cellulitis, pneumonia and lesions in the brain. An important gene associated with Nocardiosis is IL12RB1 (Interleukin 12 Receptor Subunit Beta 1), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Affiliated tissues include brain, lung and liver, and related phenotypes are fever and fatigue

Disease Ontology : 12 An opportunistic bacterial infectious disease that results in disseminated infection in immunocompromised hosts, has material basis in Nocardia asteroides. The infection has symptom pneumonia, has symptom cellulitis, has symptom lesions in the brain or meninges, and has symptom ascending regional lymphadenopathy.

CDC : 3 Nocardiosis is a disease caused by bacteria found in soil and water. It can affect the lungs, brain, and skin. It is most common in people with weakened immune systems who have difficulty fighting off infections (for example, people with cancer or those taking certain medications such as steroids). Antibiotic treatment might be given for several months to get rid of the infection.

Wikipedia : 73 Nocardiosis is an infectious disease affecting either the lungs (pulmonary nocardiosis) or the whole... more...

Related Diseases for Nocardiosis

Diseases related to Nocardiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 608)
# Related Disease Score Top Affiliating Genes
1 actinomycosis 30.6 TNF CRP CD4
2 pleural empyema 30.5 CRP CD4
3 lymphangitis 30.4 CRP CD4
4 pulmonary tuberculosis 30.2 TNF IL12RB1 IFNG
5 vasculitis 30.1 TNF HSPD1 CRP
6 sporotrichosis 30.1 IFNG CD4
7 neuroretinitis 30.1 CRP CD4
8 bronchopneumonia 30.0 TNF CRP CD4
9 coccidioidomycosis 30.0 IL12RB1 CD4
10 cellulitis 29.9 TNF LACTB CRP CD4
11 epidural abscess 29.9 CRP CD4
12 breast abscess 29.9 CRP CD4
13 pneumocystosis 29.9 TNF CRP CD4
14 pustulosis of palm and sole 29.8 TNF CRP
15 dermatophytosis 29.8 IL12RB1 CD4
16 pemphigoid 29.8 TNF IFNG
17 suppurative thyroiditis 29.8 CRP CD4
18 mycobacterium fortuitum 29.8 LACTB IL12RB1 HSPD1
19 purpura 29.7 TNF IFNG CRP
20 bronchitis 29.6 TNF LACTB CRP
21 orchitis 29.6 TNF CRP CD4
22 pancytopenia 29.6 IFNG CRP CD4
23 tuberculous meningitis 29.6 TNF LYZ
24 neutrophilic dermatosis, acute febrile 29.5 TNF CRP
25 bacterial pneumonia 29.5 TNF LACTB CRP CD4
26 acquired immunodeficiency syndrome 29.5 TNF IFNG CRP CD4
27 compartment syndrome 29.5 TNF CRP
28 panophthalmitis 29.5 IFNG CRP CD4
29 mucormycosis 29.5 IFNG CRP CD4
30 thyroiditis 29.5 TNF IFNG CRP
31 osteomyelitis 29.5 TNF IFNG CRP
32 aspiration pneumonia 29.5 TNF LACTB CRP
33 relapsing fever 29.4 TNF HSPD1 CRP
34 cerebritis 29.4 TNF CRP CD4
35 iridocyclitis 29.4 TNF CRP CD4
36 klebsiella pneumonia 29.4 TNF CRP CD4
37 meningoencephalitis 29.4 TNF CRP CD4
38 pleural disease 29.4 TNF CRP CD4
39 bronchiolitis obliterans 29.4 TNF IFNG CRP
40 bronchiolitis 29.4 TNF IFNG CRP
41 strongyloidiasis 29.4 IFNG CD4
42 paracoccidioidomycosis 29.4 TNF IL12RB1 IFNG
43 pneumonia 29.3 TNF LACTB IFNG CRP
44 optic nerve disease 29.3 TNF CRP CD4
45 uveitis 29.3 TNF IFNG HSPD1
46 scleritis 29.3 TNF IFNG CRP
47 mycobacterium tuberculosis 1 29.3 TNF IL12RB1 IFNG HSPD1 CD4
48 primary biliary cholangitis 29.3 IL12RB2 IL12RB1 HSPD1 CD4
49 amyloidosis 29.3 TNF LYZ CRP
50 adult-onset still's disease 29.3 TNF IFNG CRP

Graphical network of the top 20 diseases related to Nocardiosis:



Diseases related to Nocardiosis

Symptoms & Phenotypes for Nocardiosis

Human phenotypes related to Nocardiosis:

58 31 (show top 50) (show all 53)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
2 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
3 immunodeficiency 58 31 frequent (33%) Frequent (79-30%) HP:0002721
4 chest pain 58 31 frequent (33%) Frequent (79-30%) HP:0100749
5 pneumonia 58 31 frequent (33%) Frequent (79-30%) HP:0002090
6 productive cough 58 31 frequent (33%) Frequent (79-30%) HP:0031245
7 bacteremia 58 31 frequent (33%) Frequent (79-30%) HP:0031864
8 reduced consciousness/confusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0004372
9 vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002013
10 subcutaneous nodule 58 31 occasional (7.5%) Occasional (29-5%) HP:0001482
11 anorexia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002039
12 emphysema 58 31 occasional (7.5%) Occasional (29-5%) HP:0002097
13 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
14 pericarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001701
15 conjunctivitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000509
16 weight loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0001824
17 osteomyelitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002754
18 sepsis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100806
19 headache 58 31 occasional (7.5%) Occasional (29-5%) HP:0002315
20 liver abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0100523
21 respiratory failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0002878
22 respiratory distress 58 31 occasional (7.5%) Occasional (29-5%) HP:0002098
23 pleural effusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0002202
24 pneumothorax 58 31 occasional (7.5%) Occasional (29-5%) HP:0002107
25 pleuritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002102
26 dacryocystitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000620
27 night sweats 58 31 occasional (7.5%) Occasional (29-5%) HP:0030166
28 ocular pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0200026
29 nonproductive cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0031246
30 chills 58 31 occasional (7.5%) Occasional (29-5%) HP:0025143
31 brain abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0030049
32 lymphadenitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002840
33 severe infection 58 31 occasional (7.5%) Occasional (29-5%) HP:0032169
34 cutaneous abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0031292
35 encephalitis 58 31 very rare (1%) Very rare (<4-1%) HP:0002383
36 abnormal heart valve morphology 58 31 very rare (1%) Very rare (<4-1%) HP:0001654
37 thyroiditis 58 31 very rare (1%) Very rare (<4-1%) HP:0100646
38 abnormality of the adrenal glands 58 31 very rare (1%) Very rare (<4-1%) HP:0000834
39 cellulitis 58 31 very rare (1%) Very rare (<4-1%) HP:0100658
40 endocarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0100584
41 meningitis 58 31 very rare (1%) Very rare (<4-1%) HP:0001287
42 keratitis 58 31 very rare (1%) Very rare (<4-1%) HP:0000491
43 scotoma 58 31 very rare (1%) Very rare (<4-1%) HP:0000575
44 peritonitis 58 31 very rare (1%) Very rare (<4-1%) HP:0002586
45 functional motor deficit 58 31 very rare (1%) Very rare (<4-1%) HP:0004302
46 abnormality of the mediastinum 58 31 very rare (1%) Very rare (<4-1%) HP:0045026
47 scleritis 58 31 very rare (1%) Very rare (<4-1%) HP:0100532
48 chorioretinitis 58 31 very rare (1%) Very rare (<4-1%) HP:0012424
49 seizure 31 very rare (1%) HP:0001250
50 seizures 58 Very rare (<4-1%)

Symptoms:

12
  • cellulitis
  • pneumonia
  • lesions in the brain
  • ascending regional lymphadenopathy

MGI Mouse Phenotypes related to Nocardiosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CD4 HSPD1 IFNG IFNGR2 IL12RB1 IL12RB2
2 immune system MP:0005387 9.23 CD4 CRP IFNG IFNGR2 IL12RB1 IL12RB2

Drugs & Therapeutics for Nocardiosis

Search Clinical Trials , NIH Clinical Center for Nocardiosis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


acetyl sulfisoxazole
Sulfisoxazole
Sulfisoxazole Diolamine

Cochrane evidence based reviews: nocardia infections

Genetic Tests for Nocardiosis

Anatomical Context for Nocardiosis

MalaCards organs/tissues related to Nocardiosis:

40
Brain, Lung, Liver, Skin, Heart, Kidney, Bone Marrow

Publications for Nocardiosis

Articles related to Nocardiosis:

(show top 50) (show all 1810)
# Title Authors PMID Year
1
Recombinant resuscitation-promoting factor protein of Nocardia seriolae, a promissing vaccine candidate for largemouth bass (Micropterus salmoides). 61
33545184 2021
2
Pulmonary infections after renal transplantation: a prospective study from a tropical country. 61
33423313 2021
3
Infective endocarditis caused by Nocardia nova: A case report and literature review of nocardial endocarditis. 61
33722464 2021
4
Thyroid nocardiosis: Case report and review of the literature. 61
33650134 2021
5
Pulmonary Nocardiosis with Superior Vena Cava Syndrome in a HIV-Infected Patient: a Rare Case Report in the World. 61
32741927 2021
6
Long-term use of liposomal nebulized amikacin and tedizolid for the treatment of disseminated nocardiosis after allogeneic hematopoietic stem cell transplantation. 61
33694036 2021
7
Rare nocardiosis in danish patient with diabetes. 61
33708362 2021
8
False-positive galactomannan antigen testing in pulmonary nocardiosis. 61
32944777 2021
9
Disseminated nocardiosis in an immunosuppressed patient with systemic lupus erythematosus and neuromyelitis optica spectrum disorder. 61
33259737 2021
10
Sulfonamides without trimethoprim in the treatment of Nocardia infections: A case report and literature review. 61
32869901 2021
11
Primary cerebellar nocardiosis in a patient with myasthenia gravis. 61
33610244 2021
12
Mycetoma and the Community Dermatology Program, Mexico. 61
33479763 2021
13
Deep mycoses and pseudomycoses of the foot: a single-center retrospective study of 160 cases, in a tertiary-care center in Mexico. 61
33453613 2021
14
Suppurative necrotizing bronchopneumonia caused by Nocardia cyriacigeorgica infection in a stranded striped dolphin (Stenella coeruleoalba) in Japan. 61
33310996 2021
15
Nocardiosis in a patient with pemphigus foliaceus treated with rituximab. 61
33247992 2021
16
Pulmonary nocardiosis in a patient with pemphigus foliaceus: case report and literature review. 61
33407179 2021
17
Rapid and accurate diagnosis of brain abscess caused by Nocardia asiatica with a combination of Ziehl-Neelsen staining and metagenomics next-generation sequencing. 61
32920981 2021
18
How do I manage nocardiosis? 61
33418019 2021
19
Disseminated Nocardiosis in a Renal Transplant Recipient. 61
33564506 2021
20
Case Report: Spontaneous Carinal Perforation and Bronchonodal Fistula due to Pulmonary Nocardiosis in an HIV-Infected Patient. 61
33534760 2021
21
Revisiting nocardiosis at a tertiary care institution: Any change in recent years? 61
33157288 2021
22
[Sporotrichoid nocardiosis by Nocardia brasiliensis]. 61
32739070 2021
23
Systemic nocardiosis in acquired aplastic anaemia: Report of 2 cases. 61
32534743 2021
24
Nocardia beijingensis lung mass in an immunocompetent adult. 61
33500298 2021
25
Nocardia Subretinal Abscess: A Rare and Challenging Case Report. 61
33505746 2021
26
Identification of a secreted superoxide dismutase (SOD) from Nocardia seriolae which induces apoptosis in fathead minnow (FHM) cells. 61
32959416 2021
27
Invasive nocardiosis, disseminated varicella zoster reactivation, and pneumocystis jiroveci pneumonia associated with tofacitinib and concomitant systemic corticosteroid use in ulcerative colitis. 61
32918841 2020
28
Nocardiosis-an uncommon infection in patients with myasthenia gravis: report of three cases and review of literature. 61
33384345 2020
29
Ganglionar cutaneous nocardiosis in a patient with AIDS. 61
32980555 2020
30
Abdominopelvic Actinomycosis Mimicking a Malignant Ovarian Neoplasia: Case Report and Review of Literature. 61
33489593 2020
31
Severe Nocardia pneumonia in an immunocompromised patient with alpha-1 antitrypsin deficiency. 61
33005425 2020
32
Nocardiosis Associated with Primary Immunodeficiencies (Nocar-DIP): an International Retrospective Study and Literature Review. 61
32920680 2020
33
Nocardia farcinica Brain Abscess in an Immunocompetent Host With Pulmonary Alveolar Proteinosis: A Case Report and Review of the Literature. 61
33354440 2020
34
Subretinal abscess as an initial presentation of systemic nocardiosis. 61
33139365 2020
35
Lymphocutaneous nocardiosis successfully treated with cotrimoxazole in an immunocompetent adult: A case report. 61
33078883 2020
36
Nocardiosis in graft recipients of kidneys from extended-criteria donors following switch to belatacept complicated by acute rejection. 61
32866997 2020
37
Nocardiosis in glomerular disease patients with immunosuppressive therapy. 61
33243202 2020
38
Nocardia seriolae: a serious threat to the largemouth bass Micropterus salmoides industry in Southwest China. 61
33150871 2020
39
Disseminated nocardiosis with adrenal abscess masquerading as metastatic adrenal cancer in an immunocompetent adult. 61
33137243 2020
40
Asymptomatic cerebral abscesses after pleuropulmonary Nocardia farcinica infection. 61
33299565 2020
41
Immunogenicity and efficacy of two DNA vaccines encoding antigenic PspA and TerD against Nocardia seriolae in hybrid snakehead. 61
32846242 2020
42
Ruptured Mycotic Cerebral Aneurysm Secondary to Disseminated Nocardiosis. 61
33708692 2020
43
Clinical features and prognosis of nocardiosis in patients with connective tissue diseases. 61
32930047 2020
44
Case of Nocardia Cyriacigeorgica Infection of the Eye in a Granulomatosis With Polyangiitis Patient. 61
33133800 2020
45
Recent Trends of Infectious Complications Following Heart Transplantation. 61
32413012 2020
46
Nontuberculous mycobacterial and Nocardia infections mimicking pulmonary tuberculosis: a retrospective study of a general hospital patient population in China. 61
31021740 2020
47
Diagnosis and treatment of lymphocutaneous dermatosis caused by Nocardia brasiliensis: a case report. 61
32921116 2020
48
Nocardia farcinica masquerading as intracerebral metastases in advanced metastatic prostatic cancer. 61
32900716 2020
49
Prompt identification of primary cutaneous nocardiosis with immunohistochemical staining. 61
32835044 2020
50
Advanced multimodality MR imaging of a cerebral nocardiosis abscess in an immunocompetent patient with a focus on Amide Proton Transfer weighted imaging. 61
33029379 2020

Variations for Nocardiosis

Expression for Nocardiosis

Search GEO for disease gene expression data for Nocardiosis.

Pathways for Nocardiosis

Pathways related to Nocardiosis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 TNF LYZ IL12RB2 IL12RB1 IFNGR2 IFNG
2
Show member pathways
13.31 TNF IL12RB2 IL12RB1 IFNGR2 IFNG CD4
3
Show member pathways
13.11 TNF IL12RB2 IL12RB1 IFNGR2 IFNG CD4
4 12.65 IL12RB2 IL12RB1 IFNGR2 IFNG
5
Show member pathways
12.65 TNF IFNG HSPD1 CD4
6
Show member pathways
12.4 TNF IFNGR2 IFNG CD4
7
Show member pathways
12.38 TNF IL12RB1 IFNG CD4
8
Show member pathways
12.29 TNF IL12RB2 IL12RB1 IFNGR2 IFNG CD4
9
Show member pathways
12.19 IL12RB2 IL12RB1 IFNGR2 IFNG
10
Show member pathways
12.17 TNF IL12RB2 IL12RB1 IFNGR2 IFNG CD4
11
Show member pathways
12.02 TNF IFNGR2 IFNG
12 12 TNF IFNGR2 IFNG
13
Show member pathways
11.99 TNF IFNGR2 IFNG
14 11.99 TNF IFNGR2 IFNG HSPD1
15 11.81 TNF IFNG CD4
16
Show member pathways
11.68 IL12RB2 IL12RB1 IFNG CD4
17
Show member pathways
11.67 IL12RB1 IFNG CD4
18 11.56 TNF IFNG CD4
19
Show member pathways
11.36 TNF IFNGR2 IFNG
20 11.3 IL12RB2 IFNG CD4
21 11.26 TNF IL12RB2 IL12RB1 IFNG CD4
22
Show member pathways
11.04 IL12RB2 IL12RB1 IFNG
23 11.01 TNF IFNG CD4
24
Show member pathways
10.98 TNF IL12RB2 IL12RB1 IFNGR2 IFNG CD4
25 10.86 TNF CRP

GO Terms for Nocardiosis

Cellular components related to Nocardiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 TNF LYZ IFNG HSPD1 CSN1S1 CRP
2 external side of plasma membrane GO:0009897 8.92 TNF IL12RB2 IL12RB1 CD4

Biological processes related to Nocardiosis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.78 IL12RB2 IFNGR2 IFNG CD4
2 response to virus GO:0009615 9.73 TNF IFNGR2 IFNG
3 defense response to Gram-positive bacterium GO:0050830 9.71 TNF LYZ CRP
4 positive regulation of inflammatory response GO:0050729 9.69 TNF IFNG HSPD1
5 positive regulation of interleukin-6 production GO:0032755 9.67 TNF IFNG HSPD1
6 positive regulation of T cell activation GO:0050870 9.61 HSPD1 CD4
7 positive regulation of osteoclast differentiation GO:0045672 9.6 TNF IFNG
8 macrophage differentiation GO:0030225 9.59 IFNG CD4
9 positive regulation of amyloid-beta formation GO:1902004 9.58 TNF IFNG
10 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 TNF IFNG
11 interleukin-12-mediated signaling pathway GO:0035722 9.58 IL12RB2 IL12RB1 IFNG
12 astrocyte activation GO:0048143 9.57 TNF IFNG
13 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.55 IFNGR2 IFNG
14 negative regulation of amyloid-beta clearance GO:1900222 9.52 TNF IFNG
15 negative regulation of lipid storage GO:0010888 9.46 TNF CRP
16 positive regulation of NMDA glutamate receptor activity GO:1904783 9.43 IFNGR2 IFNG
17 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 TNF IFNG
18 cytokine-mediated signaling pathway GO:0019221 9.35 TNF IL12RB2 IL12RB1 IFNGR2 CD4
19 microglial cell activation GO:0001774 9.33 TNF IFNGR2 IFNG
20 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 TNF IFNG
21 positive regulation of nitrogen compound metabolic process GO:0051173 9.26 TNF IFNG
22 positive regulation of interferon-gamma production GO:0032729 8.92 TNF IL12RB2 IL12RB1 HSPD1

Molecular functions related to Nocardiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 8.8 IL12RB2 IL12RB1 IFNGR2

Sources for Nocardiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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