NMZL
MCID: NDL020
MIFTS: 29

Nodal Marginal Zone B-Cell Lymphoma (NMZL)

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Nodal Marginal Zone B-Cell Lymphoma

MalaCards integrated aliases for Nodal Marginal Zone B-Cell Lymphoma:

Name: Nodal Marginal Zone B-Cell Lymphoma 58
Monocytoid B-Cell Lymphoma 70
Nmzl 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 via Orphanet 33 C83.0
Orphanet 58 ORPHA86867
UMLS 70 C0855139

Summaries for Nodal Marginal Zone B-Cell Lymphoma

MalaCards based summary : Nodal Marginal Zone B-Cell Lymphoma, also known as monocytoid b-cell lymphoma, is related to marginal zone b-cell lymphoma and b-cell lymphoma. An important gene associated with Nodal Marginal Zone B-Cell Lymphoma is BCL2 (BCL2 Apoptosis Regulator), and among its related pathways/superpathways are Notch Signaling Pathway (WikiPathways) and NF-kappaB Signaling. The drugs rituximab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, eye and spinal cord.

Related Diseases for Nodal Marginal Zone B-Cell Lymphoma

Diseases related to Nodal Marginal Zone B-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 marginal zone b-cell lymphoma 30.8 MALT1 BCL6 BCL2
2 b-cell lymphoma 30.8 MALT1 BCL6 BCL2
3 follicular lymphoma 30.5 BCL6 BCL2
4 lymphoma 30.5 MALT1 BCL6 BCL2
5 lymphoma, mucosa-associated lymphoid type 30.1 MALT1 BCL6 BCL2
6 diffuse large b-cell lymphoma 29.9 MALT1 BCL6 BCL2
7 mantle cell lymphoma 29.6 MALT1 BCL6 BCL2
8 nodal marginal zone lymphoma 10.6
9 lymphoplasmacytic lymphoma 10.4
10 posttransplant acute limbic encephalitis 10.4
11 leukemia, acute myeloid 10.2
12 hepatitis c virus 10.2
13 myelodysplastic syndrome 10.2
14 mulchandani-bhoj-conlin syndrome 10.2
15 lymphoproliferative syndrome 10.2
16 neutropenia 10.2
17 lymphadenitis 10.2
18 hepatitis c 10.2
19 hepatitis 10.2
20 keratopathy 10.2
21 plasmacytoma 10.2
22 composite lymphoma 10.2
23 dacryoadenitis 10.2
24 chronic myelomonocytic leukemia 9.9
25 leukemia 9.9
26 lung lymphoma 9.8 MALT1 BCL6
27 gastrointestinal lymphoma 9.8 MALT1 BCL6
28 alpha chain disease 9.8 MALT1 BCL6
29 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 9.8 BCL6 BCL2
30 central nervous system lymphoma 9.8 MALT1 BCL6
31 follicular lymphoma 1 9.8 BCL6 BCL2
32 gallbladder lymphoma 9.8 MALT1 BCL6
33 intravascular large b-cell lymphoma 9.8 BCL6 BCL2
34 spleen cancer 9.8 MALT1 BCL6
35 lymphosarcoma 9.7 BCL6 BCL2
36 gastric lymphoma 9.7 MALT1 BCL6
37 human herpesvirus 8 9.7 BCL6 BCL2
38 primary central nervous system lymphoma 9.7 BCL6 BCL2
39 orofaciodigital syndrome viii 9.7 MALT1 BCL6
40 intraocular lymphoma 9.7 BCL6 BCL2
41 reticulosarcoma 9.6 BCL6 BCL2
42 splenic marginal zone lymphoma 9.6 MALT1 BCL6
43 primary mediastinal b-cell lymphoma 9.6 BCL6 BCL2
44 lymphoma, hodgkin, classic 9.5 BCL6 BCL2
45 burkitt lymphoma 9.4 BCL6 BCL2
46 lymphoma, non-hodgkin, familial 9.4 MALT1 BCL6 BCL2

Graphical network of the top 20 diseases related to Nodal Marginal Zone B-Cell Lymphoma:



Diseases related to Nodal Marginal Zone B-Cell Lymphoma

Symptoms & Phenotypes for Nodal Marginal Zone B-Cell Lymphoma

Drugs & Therapeutics for Nodal Marginal Zone B-Cell Lymphoma

Drugs for Nodal Marginal Zone B-Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 2 174722-31-7 10201696
2 Antineoplastic Agents, Immunological Phase 2
3 Antirheumatic Agents Phase 2
4 Immunoglobulins Phase 2
5 Antibodies Phase 2
6 Antibodies, Monoclonal Phase 2
7 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Phase II Study for Zevalin® in Patients With Relapsed/Refractory Indolent Lymphomas: Extranodal Marginal Lymphoma of MALT Type, Nodal Marginal Zone B-Cell Lymphoma, and Splenic Marginal B-Cell Lymphoma Terminated NCT00493454 Phase 2 Zevalin;Rituximab;^111 In Ibritumomab Tiuxetan

Search NIH Clinical Center for Nodal Marginal Zone B-Cell Lymphoma

Genetic Tests for Nodal Marginal Zone B-Cell Lymphoma

Anatomical Context for Nodal Marginal Zone B-Cell Lymphoma

MalaCards organs/tissues related to Nodal Marginal Zone B-Cell Lymphoma:

40
Bone Marrow, Eye, Spinal Cord, T Cells, B Cells, Spleen, Lung

Publications for Nodal Marginal Zone B-Cell Lymphoma

Articles related to Nodal Marginal Zone B-Cell Lymphoma:

(show top 50) (show all 143)
# Title Authors PMID Year
1
Genome-wide DNA methylation analysis along the progression of gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type. 61
33590882 2021
2
Bilateral Primary Marginal Zone Lymphoma of the Breast - A Rare Breast Malignancy. 61
33144473 2020
3
Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease. 61
33211828 2020
4
Frequency of MYD88 L256P mutation and its correlation with clinico-hematological profile in mature B-cell neoplasm. 61
33217360 2020
5
Bendamustine-rituximab regimen in untreated indolent marginal zone lymphoma: experience on 65 patients. 61
32594531 2020
6
A case of nodal marginal zone B-cell lymphoma of the lower eyelid. 61
32867415 2020
7
IGHV mutational status of nodal marginal zone lymphoma by NGS reveals distinct pathogenic pathways with different prognostic implications. 61
31802229 2020
8
Long-Term Observation of the Progression From Nodal Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma in a Dog. 61
32608349 2020
9
Discovery of Novel Recurrent Mutations and Clinically Meaningful Subgroups in Nodal Marginal Zone Lymphoma. 61
32585984 2020
10
Expansion of PD1-positive T Cells in Nodal Marginal Zone Lymphoma: A Potential Diagnostic Pitfall. 61
31764221 2020
11
90 Y-ibritumomab tiuxetan in patients with extra-nodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) - The Zeno Study. 61
31944265 2020
12
Deletion 20q12 is associated with histological transformation of nodal marginal zone lymphoma to diffuse large B-cell lymphoma. 61
31804739 2020
13
[Transformation of CD5-positive nodal marginal zone lymphoma to diffuse large B-cell lymphoma]. 61
32224585 2020
14
Contemporary management of nodal and primary splenic marginal zone lymphoma. 61
31619091 2019
15
Predictive markers of lymphomagenesis in Sjögren's syndrome: From clinical data to molecular stratification. 61
31431317 2019
16
A case of nodal marginal zone lymphoma with hypersensitivity to mosquito bites as initial symptom. 61
31095761 2019
17
Primary hyaline vascular Castleman disease of the kidney: case report and literature review. 61
31439011 2019
18
Rapid Regression of B-Cell Non-Hodgkin's Lymphoma after Eradication of Hepatitis C Virus by Direct Antiviral Agents. 61
31543755 2019
19
[Paediatric nodal marginal zone lymphoma: a clinicopathological study of seven cases]. 61
31104676 2019
20
Prognostic significance of peripheral blood and bone marrow infiltration in newly-diagnosed canine nodal marginal zone lymphoma. 61
30902194 2019
21
FDG PET/CT as a diagnostic and prognostic tool for the evaluation of marginal zone lymphoma. 61
30734341 2019
22
Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations. 61
30484876 2019
23
[Simultaneous Laparoscopic Sigmoid Colectomy and Malignant Lymphoma Biopsy-A Case Report]. 61
30914601 2019
24
Case of Gastric Diffuse Large B-Cell Lymphoma. 61
31043941 2019
25
Antiphospholipid antibodies associated with nodal marginal zone lymphoma and its progression to diffuse large B-cell lymphoma-A case report. 61
30385086 2019
26
A patient with a diagnosis of nodal marginal zone B-cell lymphoma and a t(2;14)(p24;q32) involving MYCN and IGH. 61
30733831 2019
27
High-throughput sequencing of nodal marginal zone lymphomas identifies recurrent BRAF mutations. 61
29556019 2018
28
A Case of Synchronous Bone Marrow Chronic Myelomonocytic Leukemia (CMML) and Nodal Marginal Zone Lymphoma (NMZL). 61
30254190 2018
29
High-dose therapy and autologous stem cell transplantation in marginal zone lymphomas: a retrospective study by the EBMT Lymphoma Working Party and FIL-GITMO. 61
29984825 2018
30
Canine nodal marginal zone lymphoma: Descriptive insight into the biological behaviour. 61
29205839 2018
31
Children and adolescents with marginal zone lymphoma have an excellent prognosis with limited chemotherapy or a watch-and-wait strategy after complete resection. 61
29286565 2018
32
Simultaneous Occurrence of Rosai-Dorfman Disease and Nodal Marginal Zone Lymphoma in a Patient with Sjögren's Syndrome. 61
30305966 2018
33
The bendamustine plus rituximab regimen is active against primary nodal marginal zone B-cell lymphoma. 61
27443419 2017
34
Results of Upfront Therapy for Marginal Zone Lymphoma. 61
29042174 2017
35
Improved biological insight and influence on management in indolent lymphoma. Talk 3: update on nodal and splenic marginal zone lymphoma. 61
29222281 2017
36
Detection of MYD88 L265P and WHIM-like CXCR4 mutation in patients with IgM monoclonal gammopathy related disease. 61
28280994 2017
37
Analysis of Clinical Characteristics for 24 Cases of Nodal Marginal Zone Lymphoma. 61
28483023 2017
38
Nodal marginal zone lymphoma: Clinical features, diagnosis, management and treatment. 61
28288722 2017
39
Molecular pathogenesis of splenic and nodal marginal zone lymphoma. 61
28288716 2017
40
Pathology of nodal marginal zone lymphomas. 61
28288717 2017
41
Long-term outcome for patients with early stage marginal zone lymphoma and mantle cell lymphoma. 61
27389974 2017
42
Recurrent mutations in genes involved in nuclear factor-κB signalling in nodal marginal zone lymphoma-diagnostic and therapeutic implications. 61
27297871 2017
43
Dual institution experience of nodal marginal zone lymphoma reveals excellent long-term outcomes in the rituximab era. 61
27443247 2016
44
The genetics of nodal marginal zone lymphoma. 61
27335277 2016
45
Clinical features of patients with nodal marginal zone lymphoma compared to follicular lymphoma: similar presentation, but differences in prognostic factors and rate of transformation. 61
26694256 2016
46
Optimizing therapy for nodal marginal zone lymphoma. 61
26989202 2016
47
Minimal change disease: an unusual presentation of marginal zone MALT lymphoma. 61
26636329 2016
48
Misdiagnosis of primary hepatic marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type, a case report. 61
26956381 2016
49
A subset of low-grade B cell lymphomas with a follicular growth pattern but without a BCL2 translocation shows features suggestive of nodal marginal zone lymphoma. 61
26949422 2016
50
Indolent lymphomas in the pediatric population: follicular lymphoma, IRF4/MUM1+ lymphoma, nodal marginal zone lymphoma and chronic lymphocytic leukemia. 61
26416032 2016

Variations for Nodal Marginal Zone B-Cell Lymphoma

Expression for Nodal Marginal Zone B-Cell Lymphoma

Search GEO for disease gene expression data for Nodal Marginal Zone B-Cell Lymphoma.

Pathways for Nodal Marginal Zone B-Cell Lymphoma

GO Terms for Nodal Marginal Zone B-Cell Lymphoma

Biological processes related to Nodal Marginal Zone B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.4 BCL6 BCL2
2 negative regulation of cell growth GO:0030308 9.37 BCL6 BCL2
3 negative regulation of apoptotic process GO:0043066 9.33 MALT1 BCL6 BCL2
4 cell morphogenesis GO:0000902 9.32 BCL6 BCL2
5 B cell differentiation GO:0030183 9.26 BCL6 BCL2
6 positive regulation of B cell proliferation GO:0030890 8.96 BCL6 BCL2
7 regulation of apoptotic process GO:0042981 8.8 MALT1 BCL6 BCL2

Molecular functions related to Nodal Marginal Zone B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.13 MALT1 BCL6 BCL2
2 protease binding GO:0002020 8.62 MALT1 BCL2

Sources for Nodal Marginal Zone B-Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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