MCID: NDL020
MIFTS: 38

Nodal Marginal Zone B-Cell Lymphoma

Categories: Blood diseases, Rare diseases, Immune diseases

Aliases & Classifications for Nodal Marginal Zone B-Cell Lymphoma

MalaCards integrated aliases for Nodal Marginal Zone B-Cell Lymphoma:

Name: Nodal Marginal Zone B-Cell Lymphoma 59
Monocytoid B-Cell Lymphoma 73
Nmzl 59

Classifications:



External Ids:

Orphanet 59 ORPHA86867
ICD10 via Orphanet 34 C83.0
UMLS 73 C0855139

Summaries for Nodal Marginal Zone B-Cell Lymphoma

MalaCards based summary : Nodal Marginal Zone B-Cell Lymphoma, also known as monocytoid b-cell lymphoma, is related to marginal zone b-cell lymphoma and b-cell lymphomas. An important gene associated with Nodal Marginal Zone B-Cell Lymphoma is BCL6 (B Cell CLL/Lymphoma 6), and among its related pathways/superpathways are Notch signaling pathway (KEGG) and NF-kappaB Signaling. The drugs Lenograstim and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and bone marrow.

Related Diseases for Nodal Marginal Zone B-Cell Lymphoma

Graphical network of the top 20 diseases related to Nodal Marginal Zone B-Cell Lymphoma:



Diseases related to Nodal Marginal Zone B-Cell Lymphoma

Symptoms & Phenotypes for Nodal Marginal Zone B-Cell Lymphoma

Drugs & Therapeutics for Nodal Marginal Zone B-Cell Lymphoma

Drugs for Nodal Marginal Zone B-Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 428)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
2
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
3
Thiotepa Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 52-24-4 5453
4 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
5 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
6 Antilymphocyte Serum Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
7 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
8 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
9
rituximab Approved Phase 3,Phase 1,Phase 2,Not Applicable 174722-31-7 10201696
10
Vidarabine Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 24356-66-9 32326 21704
11
Fludarabine Approved Phase 3,Phase 2,Phase 1,Not Applicable 21679-14-1, 75607-67-9 30751
12
Etoposide Approved Phase 2, Phase 3,Phase 1,Early Phase 1,Not Applicable 33419-42-0 36462
13
Doxorubicin Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 23214-92-8 31703
14
Ciprofloxacin Approved, Investigational Phase 3,Not Applicable 85721-33-1 2764
15
Carboplatin Approved Phase 2, Phase 3,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
16
Iron Approved Phase 3,Phase 2,Phase 1,Not Applicable 7439-89-6 23925
17
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
18
Cefepime Approved, Investigational Phase 3,Phase 1 88040-23-7 5479537
19
Chlorambucil Approved Phase 3 305-03-3 2708
20
Ofloxacin Approved Phase 3 82419-36-1 4583
21
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
22
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
23
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 50-02-2 5743
24
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 55-98-1 2478
25
Idarubicin Approved Phase 3 58957-92-9 42890
26
Amoxicillin Approved, Vet_approved Phase 3,Not Applicable 26787-78-0 33613
27
Melphalan Approved Phase 3,Phase 2,Phase 1,Not Applicable 148-82-3 4053 460612
28
Mycophenolic acid Approved Phase 3,Phase 2,Phase 1,Not Applicable 24280-93-1 446541
29
Mycophenolate mofetil Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 128794-94-5 5281078
30
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
31
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1 53-03-2 5865
32
Pixantrone Approved, Investigational Phase 3 144510-96-3
33
Tazobactam Approved Phase 3 89786-04-9 123630
34
Ribavirin Approved Phase 3 36791-04-5 37542
35
Captopril Approved Phase 3 62571-86-2 44093
36
Heparin Approved, Investigational Phase 3,Not Applicable 9005-49-6 772 46507594
37
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
38
Ephedrine Approved Phase 3 299-42-3 9294
39
Pseudoephedrine Approved Phase 3 90-82-4 7028
40
Methotrexate Approved Phase 3,Phase 2,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
41
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
42
Morphine Approved, Investigational Phase 3,Not Applicable 57-27-2 5288826
43
Piperacillin Approved Phase 3 66258-76-2 43672
44
Vancomycin Approved Phase 3 1404-90-6 441141 14969
45
Itraconazole Approved, Investigational Phase 3,Not Applicable 84625-61-6 55283
46
Acyclovir Approved Phase 3,Phase 2 59277-89-3 2022
47
Ondansetron Approved Phase 3,Phase 2,Phase 1,Not Applicable 99614-02-5 4595
48
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
49
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
50
Dalteparin Approved Phase 3 9005-49-6

Interventional clinical trials:

(show top 50) (show all 497)
# Name Status NCT ID Phase Drugs
1 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
2 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
3 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
4 Fludarabine and Rituximab With or Without Pixantrone in Treating Patients With Relapsed or Refractory Indolent Non-Hodgkin Lymphoma Unknown status NCT00551239 Phase 3 fludarabine phosphate;pixantrone dimaleate
5 Epoetin Alfa or Epoetin Beta With or Without Iron Infusion in Treating Anemia in Patients With Cancer Unknown status NCT00482716 Phase 3
6 Combination Chemotherapy With or Without Interferon Alfa in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma Unknown status NCT00003639 Phase 3 chlorambucil;dexamethasone;idarubicin
7 Interferon Alfa-2b Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Hodgkin's Disease or Non-Hodgkin's Lymphoma Unknown status NCT00003924 Phase 3
8 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
9 Monoclonal Antibodies in Detecting Residual Disease in Patients Who Have Been Treated for Non-Hodgkin's Lymphoma Unknown status NCT00003338 Phase 2, Phase 3
10 Radiolabeled Monoclonal Antibody in the Detection and Staging of Patients With Non-Hodgkin's Lymphoma Unknown status NCT00003337 Phase 3
11 Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome Unknown status NCT00002989 Phase 3 busulfan;cyclophosphamide;idarubicin;melphalan
12 Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
13 Safety and Efficacy Study of BCD-020 in Therapy of Indolent Non-Hodgkin's Lymphoma Completed NCT01701232 Phase 3
14 Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications Completed NCT00799461 Phase 3
15 Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder Completed NCT00755040 Phase 3 cyclosporine ophthalmic emulsion
16 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
17 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
18 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
19 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
20 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
21 Sibling Donor Peripheral Stem Cell Transplant or Sibling Donor Bone Marrow Transplant in Treating Patients With Hematologic Cancers or Other Diseases Completed NCT00438958 Phase 3
22 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
23 Rituximab and Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma Completed NCT00278421 Phase 3 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
24 Rituximab and Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With B-Cell Non-Hodgkin's Lymphoma Completed NCT00278408 Phase 3 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
25 Laboratory-Treated Donor Bone Marrow in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer Completed NCT00265837 Phase 3
26 St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer Completed NCT00005805 Phase 3
27 Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
28 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
29 Combination Chemotherapy With or Without Rituximab in Treating Patients With Newly Diagnosed Non-Hodgkin's Lymphoma Completed NCT00004112 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
30 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
31 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
32 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
33 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
34 Graft-Versus-Host Disease in Treating Patients With Recurrent or Refractory Lymphoma or Hodgkin's Disease Completed NCT00003414 Phase 3 busulfan;cyclophosphamide;cyclosporine
35 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
36 Epoetin Alfa in Treating Anemia in Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Multiple Myeloma and Anemia Caused By Chemotherapy Completed NCT00003341 Phase 3
37 Comparison of Nutritional Supplements in Preventing Weight Loss in Patients With Cancer Completed NCT00053053 Phase 3
38 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
39 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
40 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
41 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
42 Rituximab in Treating Patients With Low Tumor Burden Indolent Non-Hodgkin's Lymphoma Active, not recruiting NCT00075946 Phase 3
43 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
44 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
45 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
46 Prevention of Graft-Versus-Host Disease in Patients With Advanced Leukemia or Lymphoma Who Are Eligible for Peripheral Stem Cell Transplantation Terminated NCT00003056 Phase 3 cyclosporine;cyclosporine and methotrexate
47 Involved-Field Radiation Therapy in Treating Patients With Previously Untreated Stage I or Stage II Low-Grade Non-Hodgkin's Lymphoma Terminated NCT00014326 Phase 3
48 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2 brentuximab vedotin
49 Stem Cell Transplant in Treating Patients With Hematological Cancer or Other Disorders Unknown status NCT00740467 Phase 2 busulfan;cyclophosphamide;cyclosporine;fludarabine phosphate;mycophenolate mofetil
50 Rituximab, Fludarabine, Cyclophosphamide, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Relapsed B-Cell Non-Hodgkin's Lymphoma Unknown status NCT00397800 Phase 1, Phase 2 cyclophosphamide;fludarabine phosphate

Search NIH Clinical Center for Nodal Marginal Zone B-Cell Lymphoma

Genetic Tests for Nodal Marginal Zone B-Cell Lymphoma

Anatomical Context for Nodal Marginal Zone B-Cell Lymphoma

MalaCards organs/tissues related to Nodal Marginal Zone B-Cell Lymphoma:

41
B Cells, Bone, Bone Marrow, T Cells, Kidney, Liver, Myeloid

Publications for Nodal Marginal Zone B-Cell Lymphoma

Articles related to Nodal Marginal Zone B-Cell Lymphoma:

(show all 31)
# Title Authors Year
1
The bendamustine plus rituximab regimen is active against primary nodal marginal zone B-cell lymphoma. ( 27443419 )
2016
2
IgG4-related dacryoadenitis evolving into an extra-nodal, marginal zone B-cell lymphoma (EMZL): a tale of two lacrimal glands. ( 24977741 )
2014
3
Nodal marginal zone B-cell lymphoma showing prominent plasma cell differentiation in the pleural effusion: A case report. ( 22833332 )
2014
4
Localized conjunctival extra-nodal marginal zone B cell lymphoma with presumed Paraproteinic Crystalline Keratopathy. ( 23361873 )
2013
5
Treatment outcome of gastric extra-nodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type in the Hong Kong Chinese population: a single centre experience. ( 23730516 )
2013
6
First report of nodal marginal zone B-cell lymphoma associated with breast implants. ( 22374026 )
2012
7
Nodal marginal zone B cell lymphoma with prominent follicular colonization with deletion of chromosome 13. ( 22963839 )
2012
8
Nodal marginal zone B-cell lymphoma: a diagnostic and therapeutic dilemma. ( 22393802 )
2012
9
Cavitary pulmonary involvement of diffuse large B-cell lymphoma transformed from extra nodal marginal zone B-cell lymphoma MALT type. ( 26189744 )
2011
10
Secondary nodal marginal zone B cell lymphoma arising in primary mixed cellularity subtype of Hodgkin's lymphoma. ( 19125250 )
2009
11
Immunoarchitectural patterns in nodal marginal zone B-cell lymphoma: a study of 51 cases. ( 19864232 )
2009
12
Nodal marginal zone B-cell lymphoma with prominent follicular colonization - difficulties in diagnosis: a study of 15 cases. ( 18269584 )
2008
13
Clinical implications of nodal marginal zone B-cell lymphoma among Japanese: study of 65 cases. ( 17052258 )
2007
14
Primary nodal marginal zone B-cell lymphoma: clinical features and prognostic assessment of a rare disease. ( 17233821 )
2007
15
Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin. ( 17476282 )
2007
16
Genome-wide array-based comparative genomic hybridization of ocular marginal zone B cell lymphoma: comparison with pulmonary and nodal marginal zone B cell lymphoma. ( 17492759 )
2007
17
Nodal marginal zone B-cell lymphoma associated with SjAPgren's syndrome: a report of three cases. ( 17577789 )
2007
18
CD20+ nodal marginal zone B-cell lymphoma with CD20-recurrence as an intracranial dural-based mass. ( 17071504 )
2006
19
Nodal marginal zone B-cell lymphoma: Analysis of 36 cases. Clinical presentation and treatment outcomes of nodal marginal zone B-cell lymphoma. ( 16847665 )
2006
20
A clinicopathological study of nodal marginal zone B-cell lymphoma. A report on 21 cases. ( 16405665 )
2006
21
Florid monocytoid B-cell hyperplasia resembling nodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue type. A histological and immunohistochemical study of four cases. ( 16989959 )
2006
22
Follicular colonization of nodal marginal-zone B-cell lymphoma resembling follicular lymphoma: report of 6 cases. ( 15735858 )
2005
23
A common clonal origin of nodal marginal zone B-cell lymphoma and plasma cell myeloma demonstrating different immunophenotypes: a case report of composite lymphoma. ( 15167008 )
2004
24
Nodal marginal zone B-cell lymphoma with a novel t(X;5)(q28;q22): conventional and molecular cytogenetic analysis. ( 12781450 )
2003
25
Nodal marginal zone B-cell lymphoma resembling plasmacytoma arising from a plasma cell variant of localized Castleman's disease: a case report. ( 12390409 )
2002
26
Immunoglobulin gene mutations and frequent use of VH1-69 and VH4-34 segments in hepatitis C virus-positive and hepatitis C virus-negative nodal marginal zone B-cell lymphoma. ( 11438472 )
2001
27
Detection of AP12-MALT1 chimaeric gene in extranodal and nodal marginal zone B-cell lymphoma by reverse transcription polymerase chain reaction (PCR) and genomic long and accurate PCR analyses. ( 11736940 )
2001
28
Primary nodal marginal zone B-cell lymphoma arising from more than one clonal neoplastic population. ( 11100064 )
2000
29
Retreatment with chimeric CD 20 monoclonal antibody in a patient with nodal marginal zone B-cell lymphoma. ( 10962535 )
2000
30
Nodal monocytoid B-cell lymphoma (nodal marginal-zone B-cell lymphoma). ( 10319381 )
1999
31
Nodal marginal zone B-cell lymphoma with peculiar follicular colonization involved by malignant lymphoma of thyroid gland. ( 9870160 )
1998

Variations for Nodal Marginal Zone B-Cell Lymphoma

Expression for Nodal Marginal Zone B-Cell Lymphoma

Search GEO for disease gene expression data for Nodal Marginal Zone B-Cell Lymphoma.

Pathways for Nodal Marginal Zone B-Cell Lymphoma

GO Terms for Nodal Marginal Zone B-Cell Lymphoma

Biological processes related to Nodal Marginal Zone B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.4 BCL2 BCL6
2 negative regulation of cell growth GO:0030308 9.37 BCL2 BCL6
3 negative regulation of apoptotic process GO:0043066 9.33 BCL2 BCL6 MALT1
4 cell morphogenesis GO:0000902 9.32 BCL2 BCL6
5 B cell differentiation GO:0030183 9.26 BCL2 BCL6
6 positive regulation of B cell proliferation GO:0030890 8.96 BCL2 BCL6
7 regulation of apoptotic process GO:0042981 8.8 BCL2 BCL6 MALT1

Molecular functions related to Nodal Marginal Zone B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.13 BCL2 BCL6 MALT1
2 protease binding GO:0002020 8.62 BCL2 MALT1

Sources for Nodal Marginal Zone B-Cell Lymphoma

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