MCID: NDL024
MIFTS: 36

Nodal Marginal Zone Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Nodal Marginal Zone Lymphoma

MalaCards integrated aliases for Nodal Marginal Zone Lymphoma:

Name: Nodal Marginal Zone Lymphoma 12 15
Mucosa-Associated Lymphoid Tissue Lymphoma 70
Monocytoid B-Cell Lymphoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0080211
NCIt 50 C8863
UMLS 70 C0242647 C0855139

Summaries for Nodal Marginal Zone Lymphoma

Disease Ontology : 12 A marginal zone B-cell lymphoma which morphologically resembles lymph nodes involved by marginal zone lymphomas of extranodal or splenic types, but without evidence of extranodal or splenic disease.

MalaCards based summary : Nodal Marginal Zone Lymphoma, also known as mucosa-associated lymphoid tissue lymphoma, is related to splenic marginal zone lymphoma and lymphoma, hodgkin, classic. An important gene associated with Nodal Marginal Zone Lymphoma is MNDA (Myeloid Cell Nuclear Differentiation Antigen), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Dendritic Cells Developmental Lineage Pathway. The drugs rituximab and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, thyroid and bone marrow, and related phenotypes are hematopoietic system and immune system

Related Diseases for Nodal Marginal Zone Lymphoma

Diseases related to Nodal Marginal Zone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 splenic marginal zone lymphoma 30.8 NOTCH2 CD5 BCL6
2 lymphoma, hodgkin, classic 30.5 KDM4C IRF4 BCL6
3 follicular lymphoma 30.4 MME IRF4 IGH CD5 BCL6
4 lymphoma 30.3 IRF4 GCSAM FCRL4 CD5 CASP3 BCL6
5 marginal zone b-cell lymphoma 30.1 SPN MME KDM4C IRF4 IGHV4-38-2 CD5
6 peripheral t-cell lymphoma 30.1 MME CD5 BCL6
7 composite lymphoma 29.7 MME IGHV4-38-2 CD5 BCL6
8 diffuse large b-cell lymphoma 29.7 SPN MME IRF4 GCSAM CD5 BCL6
9 b-cell lymphoma 29.6 MME IRF4 IGH GCSAM CD5 CASP3
10 mantle cell lymphoma 29.5 SPN MME IGH CD5 CASP3 BCL6
11 lymphoplasmacytic lymphoma 29.4 MME KDM4C IGHV4-38-2 IGH CD5 BCL6
12 lymphoma, mucosa-associated lymphoid type 28.7 SPN MME KDM4C IRF4 IGHV4-38-2 IGH
13 lymphoma, non-hodgkin, familial 28.5 SPN MME KDM4C IRF4 IGHV4-38-2 IGH
14 leukemia, chronic lymphocytic 28.3 SPN MME KDM4C IRF4 IGHV4-38-2 IGH
15 nodal marginal zone b-cell lymphoma 10.9
16 rosai-dorfman disease 10.4
17 myelodysplastic syndrome 10.3
18 lymphoproliferative syndrome 10.3
19 allergic disease 10.3
20 thyrotoxic exophthalmos 10.2 MME CD5
21 endocrine exophthalmos 10.2 MME CD5
22 cervical carcinosarcoma 10.2 MME BIRC5
23 sclerosing hepatic carcinoma 10.2 MME CD5
24 follicular lymphoma 1 10.2 IGH BCL6
25 primary mediastinal large b-cell lymphoma 10.1 IRF4 BCL6
26 lymphosarcoma 10.1 IGH BCL6
27 immunoglobulin a deficiency 1 10.1
28 anemia, autoimmune hemolytic 10.1
29 immune deficiency disease 10.1
30 deficiency anemia 10.1
31 anaplastic large cell lymphoma 10.1
32 breast implant-associated anaplastic large cell lymphoma 10.1
33 chronic myelomonocytic leukemia 10.1
34 b-lymphoblastic leukemia/lymphoma 10.1
35 leukemia 10.1
36 monoclonal paraproteinemia 10.1
37 histiocytosis 10.1
38 hemolytic anemia 10.1
39 arthritis 10.1
40 subcorneal pustular dermatosis 10.1
41 exophthalmos 10.1
42 toxoplasmosis 10.1
43 hydroa vacciniforme 10.1
44 progressive transformation of germinal centers 10.1
45 splenomegaly 10.1
46 posttransplant acute limbic encephalitis 10.1
47 primary cutaneous marginal zone b-cell lymphoma 10.1
48 b-cell non-hodgkin lymphoma 10.1
49 rare tumor 10.1
50 heavy chain deposition disease 10.1

Graphical network of the top 20 diseases related to Nodal Marginal Zone Lymphoma:



Diseases related to Nodal Marginal Zone Lymphoma

Symptoms & Phenotypes for Nodal Marginal Zone Lymphoma

MGI Mouse Phenotypes related to Nodal Marginal Zone Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 BCL6 BIRC5 CASP3 CD5 DDX6 IRF4
2 immune system MP:0005387 9.36 BCL6 BIRC5 CASP3 CD5 GCSAM IRF4

Drugs & Therapeutics for Nodal Marginal Zone Lymphoma

Drugs for Nodal Marginal Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 2 174722-31-7 10201696
2 Antirheumatic Agents Phase 2
3 Antineoplastic Agents, Immunological Phase 2
4 Complement System Proteins Phase 2
5 Immunologic Factors Phase 2
6
Sargramostim Approved, Investigational 123774-72-1, 83869-56-1
7
alemtuzumab Approved, Investigational 216503-57-0
8
Lenograstim Approved, Investigational 135968-09-1
9
Bortezomib Approved, Investigational 179324-69-7 387447 93860
10
Lenalidomide Approved 191732-72-6 216326
11
Thalidomide Approved, Investigational, Withdrawn 50-35-1 5426
12 Bendamustine Hydrochloride

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study on Activity and Tolerability of Intralesional Rituximab in Patients With Relapsed or Refractory CD20+ Indolent Lymphomas of Conjunctiva; Activity of Supplemental Autologous Serum in Patients Not Responsive to Rituximab Alone Unknown status NCT01514344 Phase 2 intralesional rituximab
2 Radiation Therapy Alone for Stage 1 and 2 MALT (Mucosa-Associated Lymphoid Tissue) Lymphoma Completed NCT04465162 Phase 2
3 Lymphoma in the Orbit Unknown status NCT01302912
4 Prospective Study of Frontline Helicobacter Pylori Eradication Therapy in the Treatment of Early-stage Extragastric Mucosa-associated Lymphoid Tissue Lymphoma Unknown status NCT02987127
5 Epidemiological Registry Describing Treatment Reality and Therapy Modalities of Patients With Malignant Lymphatic Systemic Diseases (Non-Hodgkin's Lymphoma, Chronic Lymphocytic Leukemia and Multiple Myeloma) Requiring Therapy. Completed NCT00889798
6 Ultra Low Dose 4 Gy Radiation for Definitive Therapy of Gastric MALT Lymphoma Recruiting NCT03680586 Early Phase 1 Radiation Therapy

Search NIH Clinical Center for Nodal Marginal Zone Lymphoma

Genetic Tests for Nodal Marginal Zone Lymphoma

Anatomical Context for Nodal Marginal Zone Lymphoma

MalaCards organs/tissues related to Nodal Marginal Zone Lymphoma:

40
Colon, Thyroid, Bone Marrow, Breast, Salivary Gland, Bone, Prostate

Publications for Nodal Marginal Zone Lymphoma

Articles related to Nodal Marginal Zone Lymphoma:

(show top 50) (show all 1566)
# Title Authors PMID Year
1
Mucosa-associated lymphoid tissue lymphoma of the bladder: Case report. 61
33732623 2021
2
Gastric mucosa-associated lymphoid tissue lymphoma in conjunction with multiple lymphomatous polyposis in the context of Helicobacter pylori and Helicobacter suis superinfection. 61
33393060 2021
3
Correlation between 18 F-FDG PET/CT semiquantitative parameters and Ki-67 expression in pulmonary mucosa-associated lymphoid tissue lymphoma. 61
33538120 2021
4
How can we assess and measure prognosis for MALT lymphoma? A review of current findings and strategies. 61
33764848 2021
5
Establishing an endoscopic diagnostic process system (M-system) for gastric MALT lymphoma of superficial-spreading type. 61
33438732 2021
6
Efficacy of eradication therapy in Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma: A meta-analysis. 61
33400830 2021
7
Pulmonary mucosa-associated lymphoid tissue lymphoma: CT findings and pathological basis. 61
33523526 2021
8
A case of signet ring cell carcinoma and mucosa-associated lymphoid tissue lymphoma of the stomach diagnosed simultaneously via magnifying endoscopy with narrow-band imaging. 61
33389693 2021
9
Clinicopathological aspects of primary mucosa-associated lymphoid tissue lymphoma of the salivary gland: A retrospective single-center analysis of 72 cases. 61
33730431 2021
10
MALT1 as a promising target to treat lymphoma and other diseases related to MALT1 anomalies. 61
33763890 2021
11
Primary Rectal Mucosa-Associated Lymphoid Tissue Lymphoma. 61
33694054 2021
12
Primary Hepatic Mucosa-Associated Lymphoid Tissue Lymphoma in a Patient with Primary Biliary Cholangitis. 61
33677076 2021
13
A modified endoscopic full thickness resection for gastric subepithelial tumors from muscularis propria layer: Novel method. 61
33755260 2021
14
Intestinal perforation secondary to intestinal Burkitt lymphoma. 61
33524798 2021
15
Clinical course of duodenal mucosa-associated lymphoid tissue lymphoma: Comparison with gastric mucosa-associated lymphoid tissue lymphoma. 61
32573049 2021
16
Synchronous duodenal mucosa-associated lymphoid tissue lymphoma and gastric cancer. 61
32959165 2021
17
Pulmonary metastasis with coexisting pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma 20 years after endometrioid adenocarcinoma surgery: A case report. 61
33300291 2021
18
Multiple Lymphomatous Polyposis Associated With Mucosa-Associated Lymphoid Tissue Lymphoma of the Colon. 61
33654700 2021
19
DLBCL of bilateral submandibular glands and MALToma of thyroid-A rare coexistence. 61
33606321 2021
20
Prognostic factors for relapse and survival among patients with ocular adnexal lymphoma: validation of the eighth edition of the American Joint Committee on Cancer (AJCC) TNM classification. 61
32327417 2021
21
Development and validation of a prognostic nomogram for gastric marginal zone lymphoma: a Surveillance, Epidemiology and End Results-based population study. 61
33401980 2021
22
Initial Manifestation of Orbital Lymphomas: The Role of Early Diagnosis. 61
33645951 2021
23
Primary hepatic mucosa-associated lymphoid tissue lymphoma: case report and literature review. 61
33786155 2021
24
Impact of four-dimensional cone-beam computed tomography on target localization for gastric mucosa-associated lymphoid tissue lymphoma radiotherapy: reducing planning target volume. 61
33446225 2021
25
A case of gastric and duodenal mucosa-associated lymphoid tissue lymphoma with multiple gastric cancers: a case report. 61
33492581 2021
26
Differential Tissue Metabolic Signatures in IgG4-Related Ophthalmic Disease and Orbital Mucosa-Associated Lymphoid Tissue Lymphoma. 61
33439228 2021
27
The Spectrum of Helicobacter-Mediated Diseases. 61
33197219 2021
28
Rituximab-induced Ileocolitis in a Patient with Gastric MALToma: A Case Report and Literature Review. 61
33642561 2021
29
Sjögren's syndrome with nodular pulmonary amyloidosis. 61
33343903 2021
30
An Overview of Helicobacter pylori Infection. 61
33765303 2021
31
Helicobacter pylori and association between its positivity and anatomotopographic settlement in the stomach with the host age range. 61
33727504 2021
32
TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants. 61
32827707 2021
33
Mutational Analysis Reinforces the Diagnosis of Nodal Marginal Zone Lymphoma With Robust PD1-positive T-Cell Hyperplasia. 61
32520760 2021
34
Imaging of head and neck mucosa-associated lymphoid tissue lymphoma (MALToma). 61
33436095 2021
35
Conjunctival Lymphoma With Nasal Spread Through the Nasolacrimal Duct. 61
32501884 2021
36
Latest trends in the incidence of Helicobacter pylori-uninfected gastric mucosa-associated lymphoid tissue lymphoma at the Cancer Institute Hospital, Japan. 61
33486669 2021
37
NF-κB subunit RELA suppression of mucosa-associated lymphoid tissue lymphoma translocation protein 1 expression in oral carcinoma cells. 61
33482470 2021
38
A Case Report of Non-Hodgkin Low-grade B-cell Mucosa-associated Lymphoid Tissue Lymphoma Presenting as a Suspected Endodontic Lesion. 61
33045263 2021
39
Aspergillusfumigatus Recognition by Dendritic Cells Negatively Regulates Allergic Lung Inflammation through a TLR2/MyD88 Pathway. 61
32970964 2021
40
Anticancer Activity of Lesbicoumestan in Jurkat Cells via Inhibition of Oxidative Stress-Mediated Apoptosis and MALT1 Protease. 61
33401649 2021
41
Advances and novel developments in mechanisms of allergic inflammation. 61
33068299 2020
42
Clinicopathological analysis of 34 Japanese patients with EBV-positive mucocutaneous ulcer. 61
32561847 2020
43
Colonic Mucosa-associated Lymphoid Tissue Lymphoma Treated by Radiation Therapy: Report of a Case and Literature Review. 61
33361708 2020
44
[Pulmonary mucosa-associated lymphoid tissue lymphoma concurrent with lung squamous cell carcinoma: a case report and literature review]. 61
33333642 2020
45
Synchronous colonic mucosa-associated lymphoid tissue lymphoma found after surgery for adenocarcinoma: A case report and review of literature. 61
33392331 2020
46
Potential of FTIR-Spectroscopy for Drugs Screening against Helicobacter pylori. 61
33322665 2020
47
[Clinicopathological analysis of mucosa associated lymphoid tissue lymphoma secondary to Sjögren' s syndrome in salivary gland]. 61
33550334 2020
48
Frequency of MYD88 L256P mutation and its correlation with clinico-hematological profile in mature B-cell neoplasm. 61
33217360 2020
49
Successful Endoscopic Resection of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Unresponsive to Helicobacter pylori Eradication Therapy. 61
33190433 2020
50
Successful Endoscopic Resection of Residual Colonic Mucosa-Associated Lymphoid Tissue Lymphoma after Polypectomy. 61
33153250 2020

Variations for Nodal Marginal Zone Lymphoma

Expression for Nodal Marginal Zone Lymphoma

Search GEO for disease gene expression data for Nodal Marginal Zone Lymphoma.

Pathways for Nodal Marginal Zone Lymphoma

Pathways related to Nodal Marginal Zone Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 IRF4 BIRC5 BCL6
2 11 SPN MME IRF4
3 10.99 SPN NOTCH2 MME CD5

GO Terms for Nodal Marginal Zone Lymphoma

Cellular components related to Nodal Marginal Zone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 TNFRSF14 SPN IGHV4-38-2 CD5

Biological processes related to Nodal Marginal Zone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.62 NOTCH2 MNDA CASP3 BCL6
2 myeloid dendritic cell differentiation GO:0043011 9.26 NOTCH2 IRF4
3 negative regulation of B cell proliferation GO:0030889 9.16 MNDA CASP3
4 positive regulation of T cell migration GO:2000406 8.96 TNFRSF14 SPN
5 cytokine-mediated signaling pathway GO:0019221 8.92 IRF4 CASP3 BIRC5 BCL6

Sources for Nodal Marginal Zone Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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