MCID: NDL009
MIFTS: 35

Nodular Basal Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Nodular Basal Cell Carcinoma

MalaCards integrated aliases for Nodular Basal Cell Carcinoma:

Name: Nodular Basal Cell Carcinoma 12 15
Skin Nodulo-Ulcerative Basal Cell Carcinoma 12
Circumscribed Solid Basal Cell Carcinoma 12
Skin Nodular Solid Basal Cell Carcinoma 73
Nodulo-Ulcerative Basal Cell Carcinoma 73
Skin Solid Basal Cell Carcinoma 12
Skin Nodular Basal Cell Carcinoma 73
Basal Cell Carcinoma, Nodular 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4280
NCIt 50 C62282
SNOMED-CT 68 128636006 403910009

Summaries for Nodular Basal Cell Carcinoma

MalaCards based summary : Nodular Basal Cell Carcinoma, also known as skin nodulo-ulcerative basal cell carcinoma, is related to infiltrative basal cell carcinoma and basal cell carcinoma. An important gene associated with Nodular Basal Cell Carcinoma is WNT16 (Wnt Family Member 16), and among its related pathways/superpathways are Pathways in cancer and Keratinization. The drugs Imiquimod and interferons have been mentioned in the context of this disorder. Affiliated tissues include skin.

Related Diseases for Nodular Basal Cell Carcinoma

Graphical network of the top 20 diseases related to Nodular Basal Cell Carcinoma:



Diseases related to Nodular Basal Cell Carcinoma

Symptoms & Phenotypes for Nodular Basal Cell Carcinoma

Drugs & Therapeutics for Nodular Basal Cell Carcinoma

Drugs for Nodular Basal Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 4,Phase 3,Not Applicable 99011-02-6 57469
2 interferons Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
3 Adjuvants, Immunologic Phase 4,Phase 3,Not Applicable
4 Interferon Inducers Phase 4,Phase 3,Not Applicable
5
Aminolevulinic acid Approved Phase 3,Phase 2,Phase 1,Not Applicable 106-60-5 137
6 Methyl 5-aminolevulinate Phase 3,Phase 2,Phase 1,Not Applicable
7 Dermatologic Agents Phase 3,Phase 2,Phase 1,Not Applicable
8 Photosensitizing Agents Phase 3,Phase 2,Phase 1,Not Applicable
9 Anesthetics Phase 3
10
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
11 Interferon-gamma Phase 1, Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Treatment of Nodular Basal Cell Carcinoma (BCC) With Imiquimod 5% Cream After Curettage Completed NCT00314756 Phase 4 imiquimod
2 Safety and Efficacy Study of Imiquimod 5% Cream Applied 3x Per Week for 8 or 12 Weeks in Low Risk Nodular Basal Cell Carcinoma Completed NCT00204555 Phase 4 Imiquimod
3 Photodynamic Therapy (PDT) With Metvix Cream 160 mg/g Versus PDT With Placebo Cream in Patients With Primary Nodular Basal Cell Carcinoma Completed NCT00472108 Phase 3
4 Fractional CO2 Laser Assisted Photodynamic Therapy Completed NCT01260987 Phase 2, Phase 3 Conventional photodynamic therapy;Fractional CO2 laser assisted PDT
5 PDT With Metvix 160 mg/g Cream Versus PDT With Placebo Cream in Patients With Primary Nodular Basal Call Carcinoma Completed NCT00472043 Phase 3
6 Surgery Versus Combined Treatment With Curettage and Imiquimod for Nodular Basal Cell Carcinoma Active, not recruiting NCT02242929 Phase 3 Imiquimod 5% cream with prior curettage
7 A Study of the Efficacy and Safety of ASN-002 in Adult Patients With Low-risk Nodular Basal Cell Carcinoma Completed NCT02550678 Phase 1, Phase 2 5-FU
8 Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Nodular Basal Cell Carcinoma Completed NCT00108121 Phase 2 PEP005
9 Clinical Trial of Patidegib Gel 2%, 4%, and Vehicle Applied Once or Twice Daily to Decrease the GLI1 Biomarker in Sporadic Nodular Basal Cell Carcinomas Completed NCT02828111 Phase 2 patidegib gel 2% - cohort 1;patidegib gel 4% - cohort 2;Vehicle - cohort 1;patidegib gel 2% - cohort 3;patidegib gel 4% - cohort 4;vehicle - cohort 2;Vehicle - cohort 3;Vehicle - cohort 4
10 Basal Cell Carcinomas Treated With Ablative Fractional Laser and Ingenol Mebutate Completed NCT03569345 Phase 1, Phase 2 AFXl-assisted ingenol mebutate delivery
11 Topical Laser-assisted Combination Chemotherapy for Basal Cell Carcinoma― a Clinical Study Recruiting NCT03541252 Phase 1, Phase 2 AFL-assisted cisplatin+5-FU
12 Efficacy and Safety Trial of Topical Resiquimod Gel (0.06%) in Patients With Nodular Basal Cell Carcinoma Terminated NCT01808950 Phase 1, Phase 2 0.06% Resiquimod Gel - A;0.06% Resiquimod Gel - B;0.06% Resiquimod Gel - C
13 Er:YAG Ablative Fractional Laser Assisted-Photodynamic Therapy Versus Photodynamic Therapy for Basal Cell Carcinoma Completed NCT02018679 Phase 1
14 A Pilot Study of the Treatment of Facial Nodular and Nodulocystic Basal Cell Carcinoma With Double Curettage and Cautery Followed by Application of Imiquimod to the Base Unknown status NCT00463359 Not Applicable Imiquimod cream
15 Randomized Pilot Study of Treatment for BCC Using the Multiplex 595/1064 nm Laser Completed NCT02270645 Not Applicable
16 New Versus Approved Methyl-aminolevulinate Photodynamic Therapy (MAL-PDT) Regime in Basal Cell Carcinoma (BCC) Completed NCT01482104 Not Applicable MAL-PDT re-treatment;usual MAL-PDT

Search NIH Clinical Center for Nodular Basal Cell Carcinoma

Genetic Tests for Nodular Basal Cell Carcinoma

Anatomical Context for Nodular Basal Cell Carcinoma

MalaCards organs/tissues related to Nodular Basal Cell Carcinoma:

41
Skin

Publications for Nodular Basal Cell Carcinoma

Articles related to Nodular Basal Cell Carcinoma:

(show top 50) (show all 77)
# Title Authors Year
1
Excision of nodular basal cell carcinoma involving the lower eyelid tarsal skin using a grey line-splitting, posterior lamella-sparing technique. ( 29461902 )
2018
2
Nodular basal cell carcinoma of the face successfully treated with ingenol mebutate 0.015% gel. ( 29785331 )
2018
3
Macrophage subtypes in recurrent nodular basal cell carcinoma after Mohs micrographic surgery. ( 28994114 )
2017
4
A rare dermoscopic pattern of nodular basal cell carcinoma with amyloid deposition. ( 28087032 )
2017
5
Imiquimod 5% cream for the treatment of large nodular basal cell carcinoma at the medial canthal area. ( 28300740 )
2017
6
Fibroepithelioma of Pinkus in continuity with nodular basal cell carcinoma: A rare presentation. ( 27559504 )
2016
7
Electronic brachytherapy for superficial and nodular basal cell carcinoma: a report of two prospective pilot trials using different doses. ( 26985197 )
2016
8
The effect of topical diclofenac 3% and calcitriol 3A I1g/g on superficial basal cell carcinoma (sBCC) and nodular basal cell carcinoma (nBCC): A phase II, randomized controlled trial. ( 27067393 )
2016
9
Altered Expression of PRKX, WNT3 and WNT16 in Human Nodular Basal Cell Carcinoma. ( 27630294 )
2016
10
Fibroepithelioma of Pinkus in continuity with a pigmented nodular basal cell carcinoma (BCC): A dermoscopic and histologic correlation. ( 27085246 )
2016
11
A retrospective study on the effectiveness of curettage and electrodesiccation for clinically suspected primary nodular basal cell carcinoma. ( 27229620 )
2016
12
Use of clamping to enhance intralesional bleomycin therapy for nodular basal cell carcinoma. ( 27075125 )
2015
13
Differentiating Early Stage Cystic Keratoacanthoma, Nodular Basal Cell Carcinoma, and Excoriated Acne Vulgaris by Clinical Exam, Dermoscopy, and Optical Coherence Tomography: A Report of 3 Cases. ( 26060518 )
2015
14
Imiquimod cream efficacy in the treatment of periocular nodular basal cell carcinoma: a non-randomized trial. ( 25885553 )
2015
15
Er:YAG ablative fractional laser-primed photodynamic therapy with methyl aminolevulinate as an alternative treatment option for patients with thin nodular basal cell carcinoma: 12-month follow-up results of a randomized, prospective, comparative trial. ( 26551044 )
2015
16
Imiquimod 5% as Adjuvant Therapy for Incompletely Excised Infiltrative Nodular Basal Cell Carcinoma and Dermoscopy to Monitor Treatment Response. ( 26538104 )
2015
17
Efficacy and safety of electronic brachytherapy for superficial and nodular basal cell carcinoma. ( 26207112 )
2015
18
Confocal microscopy-guided laser ablation for superficial and early nodular Basal cell carcinoma: a promising surgical alternative for superficial skin cancers. ( 24827701 )
2014
19
Dermoscopy margin delineation in radiotherapy planning for superficial or nodular basal cell carcinoma. ( 25204461 )
2014
20
Nodular Basal cell carcinoma arising in a split-thickness skin graft of the scalp. ( 23241812 )
2013
21
The rate and pattern of bcl-2 and cytokeratin 15 expression in trichoepithelioma and nodular Basal cell carcinoma: a comparative study. ( 24082173 )
2013
22
Photodynamic therapy combined with cryotherapy for the treatment of nodular basal cell carcinoma. ( 24137440 )
2013
23
Fractional carbon dioxide laser improves nodular basal cell carcinoma treatment with photodynamic therapy with methyl 5-aminolevulinate. ( 23725586 )
2013
24
Fractionated 5-aminolevulinic acid photodynamic therapy after partial debulking versus surgical excision for nodular basal cell carcinoma: a randomized controlled trial with at least 5-year follow-up. ( 23566914 )
2013
25
First-in-human trial of Dz13 for nodular basal-cell carcinoma. ( 23660122 )
2013
26
Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER). ( 23660123 )
2013
27
The time-dependent accumulation of protoporphyrin IX fluorescence in nodular basal cell carcinoma following application of methyl aminolevulinate with an oxygen pressure injection device. ( 23092624 )
2012
28
Treatment of nodular basal cell carcinoma with cryotherapy and reduced protocol of imiquimod. ( 23270198 )
2012
29
Nodular Basal cell carcinoma successfully treated with intralesional 5-aminolevulinic Acid injection-photodynamic therapy. ( 23197924 )
2012
30
Photodynamic therapy with intralesional photosensitizer and laser beam application: an alternative treatment for nodular basal cell carcinoma. ( 22980263 )
2012
31
Imiquimod 5% cream as pretreatment of Mohs micrographic surgery for nodular basal cell carcinoma in the face: a prospective randomized controlled study. ( 22385074 )
2012
32
Nodular basal cell carcinoma is associated with increased hyaluronan homeostasis. ( 20849445 )
2011
33
No-needle jet intradermal aminolevulinic Acid photodynamic therapy for recurrent nodular Basal cell carcinoma of the nose: a case report. ( 21188233 )
2011
34
Fibroepithelioma of pinkus in continuity with nodular basal cell carcinoma: supporting evidence of the malignant nature of the disease. ( 20512537 )
2011
35
Central nuclear palisading in nodular basal cell carcinoma: Morphological and immunohisto-chemical concerns. ( 21088810 )
2011
36
Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened. ( 21558397 )
2011
37
Detection of human papilloma virus in normal skin and in superficial and nodular basal cell carcinomas in immunocompetent subjects. ( 21054564 )
2011
38
Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma: further explanation of a dose-escalating pilot study conducted primarily to consider the safety of this pharmacological modification. ( 19903172 )
2010
39
Probing tumor and peritumoral tissues in superficial and nodular basal cell carcinoma using polarized Raman microspectroscopy. ( 19845756 )
2010
40
Photodynamic therapy with methyl aminolevulinate for primary nodular basal cell carcinoma: results of two randomized studies. ( 20064185 )
2009
41
Imiquimod-induced vitiligo after treatment of nodular basal cell carcinoma. ( 19586497 )
2009
42
Case study: Imiquimod 5% cream in the treatment of a large nodular basal cell carcinoma. ( 19507375 )
2009
43
Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma: when statistics make a difference. ( 19438852 )
2009
44
Randomized comparison of Mohs micrographic surgery and surgical excision for small nodular basal cell carcinoma: tissue-sparing outcome. ( 19500127 )
2009
45
Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma. ( 18544077 )
2008
46
Complete remission of nodular basal cell carcinoma after combined treatment with photodynamic therapy and imiquimod 5% cream. ( 18700128 )
2008
47
Enhancement of methyl-aminolevulinate photodynamic therapy by iron chelation with CP94: an in vitro investigation and clinical dose-escalating safety study for the treatment of nodular basal cell carcinoma. ( 18239941 )
2008
48
Fractionated 5-aminolaevulinic acid-photodynamic therapy vs. surgical excision in the treatment of nodular basal cell carcinoma: results of a randomized controlled trial. ( 18717680 )
2008
49
Combination of Er:YAG laser and photodynamic therapy in the treatment of nodular basal cell carcinoma. ( 18306163 )
2008
50
A phase III, randomized, open label study to evaluate the safety and efficacy of imiquimod 5% cream applied thrice weekly for 8 and 12 weeks in the treatment of low-risk nodular basal cell carcinoma. ( 17610993 )
2007

Variations for Nodular Basal Cell Carcinoma

Cosmic variations for Nodular Basal Cell Carcinoma:

9
(show top 50) (show all 687)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6926860 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 22
2 COSM6926861 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 22
3 COSM6969201 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 22
4 COSM6953811 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 22
5 COSM6926862 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 22
6 COSM6936924 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 22
7 COSM3691166 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 22
8 COSM212945 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 22
9 COSM6953809 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 22
10 COSM6936922 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 22
11 COSM6926855 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 22
12 COSM6912933 TRAF7 skin,NS,carcinoma,basal cell carcinoma c.1802C>T p.T601I 16:2176104-2176104 22
13 COSM6949578 TP63 skin,NS,carcinoma,basal cell carcinoma c.1922C>T p.A641V 3:189894381-189894381 22
14 COSM44071 TP53 skin,NS,carcinoma,basal cell carcinoma c.955A>G p.K319E 17:7673573-7673573 22
15 COSM44097 TP53 skin,NS,carcinoma,basal cell carcinoma c.530C>T p.P177L 17:7675082-7675082 22
16 COSM44096 TP53 skin,NS,carcinoma,basal cell carcinoma c.748C>G p.P250A 17:7674215-7674215 22
17 COSM10728 TP53 skin,NS,carcinoma,basal cell carcinoma c.839G>A p.R280K 17:7673781-7673781 22
18 COSM45169 TP53 skin,NS,carcinoma,basal cell carcinoma c.326T>C p.F109S 17:7676043-7676043 22
19 COSM43842 TP53 skin,NS,carcinoma,basal cell carcinoma c.770T>C p.L257P 17:7674193-7674193 22
20 COSM43695 TP53 skin,NS,carcinoma,basal cell carcinoma c.748C>T p.P250S 17:7674215-7674215 22
21 COSM10988 TP53 skin,NS,carcinoma,basal cell carcinoma c.772G>A p.E258K 17:7674191-7674191 22
22 COSM45739 TP53 skin,NS,carcinoma,basal cell carcinoma c.677G>C p.G226A 17:7674286-7674286 22
23 COSM44295 TP53 skin,NS,carcinoma,basal cell carcinoma c.993+1G>A p.? 17:7673534-7673534 22
24 COSM43778 TP53 skin,NS,carcinoma,basal cell carcinoma c.713G>T p.C238F 17:7674250-7674250 22
25 COSM10939 TP53 skin,NS,carcinoma,basal cell carcinoma c.832C>T p.P278S 17:7673788-7673788 22
26 COSM10650 TP53 skin,NS,carcinoma,basal cell carcinoma c.529C>T p.P177S 17:7675083-7675083 22
27 COSM43665 TP53 skin,NS,carcinoma,basal cell carcinoma c.746G>C p.R249T 17:7674217-7674217 22
28 COSM10662 TP53 skin,NS,carcinoma,basal cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 22
29 COSM45774 TP53 skin,NS,carcinoma,basal cell carcinoma c.899C>G p.P300R 17:7673721-7673721 22
30 COSM10749 TP53 skin,NS,carcinoma,basal cell carcinoma c.830G>T p.C277F 17:7673790-7673790 22
31 COSM11449 TP53 skin,NS,carcinoma,basal cell carcinoma c.388C>T p.L130F 17:7675224-7675224 22
32 COSM10660 TP53 skin,NS,carcinoma,basal cell carcinoma c.818G>A p.R273H 17:7673802-7673802 22
33 COSM10771 TP53 skin,NS,carcinoma,basal cell carcinoma c.749C>T p.P250L 17:7674214-7674214 22
34 COSM44068 TP53 skin,NS,carcinoma,basal cell carcinoma c.532C>A p.H178N 17:7675080-7675080 22
35 COSM11152 TP53 skin,NS,carcinoma,basal cell carcinoma c.700T>C p.Y234H 17:7674263-7674263 22
36 COSM43582 TP53 skin,NS,carcinoma,basal cell carcinoma c.454C>T p.P152S 17:7675158-7675158 22
37 COSM10768 TP53 skin,NS,carcinoma,basal cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 22
38 COSM45834 TP53 skin,NS,carcinoma,basal cell carcinoma c.409C>A p.L137M 17:7675203-7675203 22
39 COSM10905 TP53 skin,NS,carcinoma,basal cell carcinoma c.451C>T p.P151S 17:7675161-7675161 22
40 COSM10654 TP53 skin,NS,carcinoma,basal cell carcinoma c.637C>T p.R213* 17:7674894-7674894 22
41 COSM6932 TP53 skin,NS,carcinoma,basal cell carcinoma c.733G>A p.G245S 17:7674230-7674230 22
42 COSM10648 TP53 skin,NS,carcinoma,basal cell carcinoma c.524G>A p.R175H 17:7675088-7675088 22
43 COSM45424 TP53 skin,NS,carcinoma,basal cell carcinoma c.781A>T p.S261C 17:7674182-7674182 22
44 COSM10812 TP53 skin,NS,carcinoma,basal cell carcinoma c.722C>T p.S241F 17:7674241-7674241 22
45 COSM10656 TP53 skin,NS,carcinoma,basal cell carcinoma c.742C>T p.R248W 17:7674221-7674221 22
46 COSM10659 TP53 skin,NS,carcinoma,basal cell carcinoma c.817C>T p.R273C 17:7673803-7673803 22
47 COSM10794 TP53 skin,NS,carcinoma,basal cell carcinoma c.796G>A p.G266R 17:7673824-7673824 22
48 COSM44552 TP53 skin,NS,carcinoma,basal cell carcinoma c.509C>T p.T170M 17:7675103-7675103 22
49 COSM10704 TP53 skin,NS,carcinoma,basal cell carcinoma c.844C>T p.R282W 17:7673776-7673776 22
50 COSM10726 TP53 skin,NS,carcinoma,basal cell carcinoma c.856G>A p.E286K 17:7673764-7673764 22

Expression for Nodular Basal Cell Carcinoma

Search GEO for disease gene expression data for Nodular Basal Cell Carcinoma.

Pathways for Nodular Basal Cell Carcinoma

GO Terms for Nodular Basal Cell Carcinoma

Cellular components related to Nodular Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle membrane GO:0030666 8.96 PTCH1 WNT3
2 intermediate filament GO:0005882 8.92 BFSP1 KRT15 KRT17 KRT31

Biological processes related to Nodular Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.5 KRT15 KRT17 KRT31
2 cytoskeleton organization GO:0007010 9.43 BFSP1 KRT15 KRT31
3 cell fate commitment GO:0045165 9.37 WNT16 WNT3
4 keratinocyte proliferation GO:0043616 9.16 PTCH1 WNT16
5 cornification GO:0070268 9.13 KRT15 KRT17 KRT31
6 epidermis development GO:0008544 8.92 KRT15 KRT17 KRT31 PTCH1

Molecular functions related to Nodular Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 frizzled binding GO:0005109 8.96 WNT16 WNT3
2 structural constituent of cytoskeleton GO:0005200 8.92 BFSP1 KRT15 KRT17 KRT31

Sources for Nodular Basal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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