MCID: NDL008
MIFTS: 29

Nodular Episcleritis

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Nodular Episcleritis

MalaCards integrated aliases for Nodular Episcleritis:

Name: Nodular Episcleritis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:728
ICD9CM 34 379.02
SNOMED-CT 67 70558001
ICD10 32 H15.12
UMLS 71 C0155352

Summaries for Nodular Episcleritis

Disease Ontology : 12 A scleral disease that is characterized by painful inflammation with surface nodule formation of the episcleral tissues that, importantly, spares the sclera itself and has symptom pain, red eyes, photophobia, tearing, blurry vision, and appearance of eye surface irregularity. Nodular episcleritis is typically self-limited and may be caused by vascular congestion within the superficial episcleral plexus.

MalaCards based summary : Nodular Episcleritis is related to scleritis and systemic lupus erythematosus, and has symptoms including pain An important gene associated with Nodular Episcleritis is PSMB8 (Proteasome 20S Subunit Beta 8), and among its related pathways/superpathways are Metabolism of proteins and Class I MHC mediated antigen processing and presentation. Affiliated tissues include eye, and related phenotypes are FOXO1 nuclear localization and FOXO1 nuclear localization

Related Diseases for Nodular Episcleritis

Diseases related to Nodular Episcleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 scleritis 10.1
2 systemic lupus erythematosus 9.9
3 myeloma, multiple 9.9
4 disease by infectious agent 9.9
5 anterior scleritis 9.9
6 polyneuropathy 9.9
7 relapsing polychondritis 9.9
8 vasculitis 9.9
9 lupus erythematosus 9.9
10 nakajo syndrome 9.8 PSMB8 PSMB4
11 panniculitis 9.6 PSMB8 PSMB4 OTULIN
12 proteasome-associated autoinflammatory syndrome 1 9.4 PSMB8 PSMB4 PSMA3
13 cystic fibrosis 9.0 PSMB8 PSMB4 PSMB3 PSMA3

Graphical network of the top 20 diseases related to Nodular Episcleritis:



Diseases related to Nodular Episcleritis

Symptoms & Phenotypes for Nodular Episcleritis

Symptoms:

12
  • pain

GenomeRNAi Phenotypes related to Nodular Episcleritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 FOXO1 nuclear localization GR00247-A-1 9.73 POMP PSMA3 PSMB3
2 FOXO1 nuclear localization GR00247-A-2 9.73 POMP PSMA3 PSMB3
3 Decreased Salmonella enterica Typhimurium invasion GR00133-A-1 9.5 PSMA3 PSMB3 PSMB8
4 Decreased Salmonella enterica Typhimurium ruffling GR00133-A-5 9.26 PSMA3 PSMB3
5 Downregulation of NFkappaB pathway GR00313-A 9.16 POMP PSMB3
6 HIV Rev nuclear localization GR00247-A-3 8.62 POMP PSMB3

Drugs & Therapeutics for Nodular Episcleritis

Search Clinical Trials , NIH Clinical Center for Nodular Episcleritis

Genetic Tests for Nodular Episcleritis

Anatomical Context for Nodular Episcleritis

MalaCards organs/tissues related to Nodular Episcleritis:

40
Eye

Publications for Nodular Episcleritis

Articles related to Nodular Episcleritis:

(show all 28)
# Title Authors PMID Year
1
Bilateral Nodular Episcleritis: A Rare Presentation of Relapsing Polychondritis. 61
33060514 2020
2
Case Report: Primary Conjunctival Non-Hodgkin Marginal Zone Lymphoma. 61
30589762 2019
3
Episcleritis in a patient with mucosal melanoma treated with interferon alfa-2b and radiotherapy: a case report. 61
30579358 2018
4
An OCT Study of Anterior Nodular Episcleritis and Scleritis. 61
28348907 2017
5
Pseudoepitheliomatous Hyperplasia as a Limbal Mass Mimicking Nodular Episcleritis. 61
27051264 2016
6
Tubercular Nodular Episcleritis: A Case Report. 61
26435978 2015
7
Conjunctival Angioimmunoblastic T-Cell Lymphoma. 61
27231687 2015
8
[Nodular episcleritis: an unusual inaugural manifestation of Horton disease]. 61
26401214 2015
9
Nodular episcleritis after laser in situ keratomileusis in patient with systemic lupus erythematosus. 61
23772134 2013
10
Tubercular nodular episcleritis. 61
22973786 2012
11
Clinical and radiological features of Takayasu's arteritis patients in Jordan. 61
19862530 2010
12
Ocular manifestations associated with chikungunya. 61
17631967 2008
13
Keratectasia as a presentation of surgically induced necrotizing sclerokeratitis (SINS). 61
17993831 2007
14
Multifocal nodular episcleritis and scleritis with undiagnosed Hodgkin's lymphoma. 61
12750114 2003
15
Acute febrile neutrophilic dermatosis (Sweet's syndrome) with nodular episcleritis and polyneuropathy. 61
11982648 2002
16
Successful treatment of ocular leishmaniasis. 61
11809607 2002
17
Anterior segment indocyanine green angiography in scleral inflammation. 61
10845019 2000
18
Episcleritis in childhood. 61
10599674 1999
19
Localized transscleral staphylococcal abscess simulating a neoplasm. 61
7496342 1995
20
Conjunctival ulcer in a patient with Crohn's disease. 61
7831012 1994
21
Severity of scleritis and episcleritis. 61
8115160 1994
22
Clinical profile of herpes zoster ophthalmicus. 61
1748774 1991
23
Syphilitic episcleritis and scleritis. 61
3688101 1987
24
Adverse reactions to virgin silk sutures in cataract surgery. 61
6377167 1984
25
Cogan's syndrome: a treatable cause of neurosensory deafness. 61
6610465 1984
26
Scleritis and episcleritis. 61
1268179 1976
27
[A case of leprous nodular episcleritis]?1. 61
4282230 1974
28
Local use of antistine in nodular episcleritis. 61
18135470 1949

Variations for Nodular Episcleritis

Expression for Nodular Episcleritis

Search GEO for disease gene expression data for Nodular Episcleritis.

Pathways for Nodular Episcleritis

Pathways related to Nodular Episcleritis according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 PSMB8 PSMB4 PSMB3 PSMA3 OTULIN
2
Show member pathways
13.12 PSMB8 PSMB4 PSMB3 PSMA3
3
Show member pathways
13.1 PSMB8 PSMB4 PSMB3 PSMA3
4
Show member pathways
13.06 PSMB8 PSMB4 PSMB3 PSMA3
5
Show member pathways
13.03 PSMB8 PSMB4 PSMB3 PSMA3
6
Show member pathways
12.96 PSMB8 PSMB4 PSMB3 PSMA3
7
Show member pathways
12.89 PSMB8 PSMB4 PSMB3 PSMA3
8
Show member pathways
12.85 PSMB8 PSMB4 PSMB3 PSMA3
9
Show member pathways
12.73 PSMB8 PSMB4 PSMB3 PSMA3
10
Show member pathways
12.64 PSMB8 PSMB4 PSMB3 PSMA3
11
Show member pathways
12.58 PSMB8 PSMB4 PSMB3 PSMA3
12
Show member pathways
12.57 PSMB8 PSMB4 PSMB3 PSMA3
13
Show member pathways
12.54 PSMB8 PSMB4 PSMB3 PSMA3
14
Show member pathways
12.53 PSMB4 PSMB3 PSMA3
15
Show member pathways
12.44 PSMB8 PSMB4 PSMB3 PSMA3
16
Show member pathways
12.42 PSMB8 PSMB4 PSMB3 PSMA3
17
Show member pathways
12.33 PSMB8 PSMB4 PSMB3 PSMA3
18
Show member pathways
12.27 PSMB8 PSMB4 PSMB3 PSMA3
19
Show member pathways
12.22 PSMB8 PSMB4 PSMB3 PSMA3
20
Show member pathways
12.12 PSMB8 PSMB4 PSMB3 PSMA3
21
Show member pathways
12.04 PSMB4 PSMB3 PSMA3
22 12.02 PSMB8 PSMB4 PSMB3 PSMA3
23
Show member pathways
11.97 PSMB8 PSMB4 PSMB3 PSMA3
24 11.9 PSMB4 PSMB3 PSMA3
25
Show member pathways
11.81 PSMB8 PSMB4 PSMB3 PSMA3
26 11.8 PSMB4 PSMB3 PSMA3
27
Show member pathways
11.65 PSMB4 PSMB3 PSMA3
28 11.08 PSMB8 PSMB4 PSMB3 PSMA3
29 10.99 PSMB8 PSMB4 PSMB3 PSMA3

GO Terms for Nodular Episcleritis

Cellular components related to Nodular Episcleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.8 PSMB8 PSMB4 PSMB3 PSMA3 POMP OTULIN
2 extracellular exosome GO:0070062 9.65 SPN PSMB8 PSMB4 PSMB3 PSMA3
3 proteasome core complex, beta-subunit complex GO:0019774 9.33 PSMB8 PSMB4 PSMB3
4 proteasome complex GO:0000502 9.26 PSMB8 PSMB4 PSMB3 PSMA3
5 proteasome core complex GO:0005839 8.92 PSMB8 PSMB4 PSMB3 PSMA3

Biological processes related to Nodular Episcleritis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.94 PSMB8 PSMB4 PSMB3 PSMA3
2 proteolysis GO:0006508 9.94 PSMB8 PSMB4 PSMB3 OTULIN
3 viral process GO:0016032 9.93 PSMB8 PSMB4 PSMB3 PSMA3
4 post-translational protein modification GO:0043687 9.92 PSMB8 PSMB4 PSMB3 PSMA3
5 MAPK cascade GO:0000165 9.92 PSMB8 PSMB4 PSMB3 PSMA3
6 protein polyubiquitination GO:0000209 9.91 PSMB8 PSMB4 PSMB3 PSMA3
7 protein deubiquitination GO:0016579 9.91 PSMB8 PSMB4 PSMB3 PSMA3
8 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 9.9 PSMB8 PSMB4 PSMB3 PSMA3
9 negative regulation of canonical Wnt signaling pathway GO:0090090 9.89 PSMB8 PSMB4 PSMB3 PSMA3
10 T cell receptor signaling pathway GO:0050852 9.88 PSMB8 PSMB4 PSMB3 PSMA3
11 Fc-epsilon receptor signaling pathway GO:0038095 9.88 PSMB8 PSMB4 PSMB3 PSMA3
12 positive regulation of canonical Wnt signaling pathway GO:0090263 9.87 PSMB8 PSMB4 PSMB3 PSMA3
13 tumor necrosis factor-mediated signaling pathway GO:0033209 9.86 PSMB8 PSMB4 PSMB3 PSMA3
14 regulation of mRNA stability GO:0043488 9.85 PSMB8 PSMB4 PSMB3 PSMA3
15 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.84 PSMB8 PSMB4 PSMB3 PSMA3
16 interleukin-1-mediated signaling pathway GO:0070498 9.83 PSMB8 PSMB4 PSMB3 PSMA3
17 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 9.81 PSMB8 PSMB4 PSMB3 PSMA3
18 Wnt signaling pathway, planar cell polarity pathway GO:0060071 9.8 PSMB8 PSMB4 PSMB3 PSMA3
19 anaphase-promoting complex-dependent catabolic process GO:0031145 9.78 PSMB8 PSMB4 PSMB3 PSMA3
20 regulation of mitotic cell cycle phase transition GO:1901990 9.76 PSMB8 PSMB4 PSMB3 PSMA3
21 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.73 PSMB8 PSMB4 PSMB3 PSMA3
22 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.71 PSMB8 PSMB4 PSMB3 PSMA3
23 NIK/NF-kappaB signaling GO:0038061 9.67 PSMB8 PSMB4 PSMB3 PSMA3
24 regulation of endopeptidase activity GO:0052548 9.63 PSMB8 PSMA3
25 regulation of hematopoietic stem cell differentiation GO:1902036 9.62 PSMB8 PSMB4 PSMB3 PSMA3
26 negative regulation of G2/M transition of mitotic cell cycle GO:0010972 9.56 PSMB8 PSMB4 PSMB3 PSMA3
27 proteolysis involved in cellular protein catabolic process GO:0051603 9.46 PSMB8 PSMB4 PSMB3 PSMA3
28 regulation of cellular amino acid metabolic process GO:0006521 9.26 PSMB8 PSMB4 PSMB3 PSMA3
29 proteasomal ubiquitin-independent protein catabolic process GO:0010499 8.92 PSMB8 PSMB4 PSMB3 PSMA3

Molecular functions related to Nodular Episcleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.46 PSMB8 PSMB4 PSMB3 OTULIN
2 endopeptidase activity GO:0004175 9.26 PSMB8 PSMB4 PSMB3 PSMA3
3 threonine-type endopeptidase activity GO:0004298 8.8 PSMB8 PSMB4 PSMB3

Sources for Nodular Episcleritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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