Nodular Episcleritis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: NDL008 MIFTS: 29	Nodular Episcleritis Categories: Eye diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Nodular Episcleritis

MalaCards integrated aliases for Nodular Episcleritis:

Name: Nodular Episcleritis ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:728

ICD9CM ³⁴ 379.02

SNOMED-CT ⁶⁷ 70558001

ICD10 ³² H15.12

UMLS ⁷¹ C0155352

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Summaries for Nodular Episcleritis

Disease Ontology : ¹² A scleral disease that is characterized by painful inflammation with surface nodule formation of the episcleral tissues that, importantly, spares the sclera itself and has symptom pain, red eyes, photophobia, tearing, blurry vision, and appearance of eye surface irregularity. Nodular episcleritis is typically self-limited and may be caused by vascular congestion within the superficial episcleral plexus.

MalaCards based summary : Nodular Episcleritis is related to scleritis and systemic lupus erythematosus, and has symptoms including pain An important gene associated with Nodular Episcleritis is PSMB8 (Proteasome 20S Subunit Beta 8), and among its related pathways/superpathways are Metabolism of proteins and Class I MHC mediated antigen processing and presentation. Affiliated tissues include eye, and related phenotypes are FOXO1 nuclear localization and FOXO1 nuclear localization

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Related Diseases for Nodular Episcleritis

Diseases related to Nodular Episcleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)

#	Related Disease	Score	Top Affiliating Genes
1	scleritis	10.1
2	systemic lupus erythematosus	9.9
3	myeloma, multiple	9.9
4	disease by infectious agent	9.9
5	anterior scleritis	9.9
6	polyneuropathy	9.9
7	relapsing polychondritis	9.9
8	vasculitis	9.9
9	lupus erythematosus	9.9
10	nakajo syndrome	9.8	PSMB8 PSMB4
11	panniculitis	9.6	PSMB8 PSMB4 OTULIN
12	proteasome-associated autoinflammatory syndrome 1	9.4	PSMB8 PSMB4 PSMA3
13	cystic fibrosis	9.0	PSMB8 PSMB4 PSMB3 PSMA3

Graphical network of the top 20 diseases related to Nodular Episcleritis:

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Symptoms & Phenotypes for Nodular Episcleritis

Symptoms:

¹²

• pain

GenomeRNAi Phenotypes related to Nodular Episcleritis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	FOXO1 nuclear localization	GR00247-A-1	9.73	POMP PSMA3 PSMB3
2	FOXO1 nuclear localization	GR00247-A-2	9.73	POMP PSMA3 PSMB3
3	Decreased Salmonella enterica Typhimurium invasion	GR00133-A-1	9.5	PSMA3 PSMB3 PSMB8
4	Decreased Salmonella enterica Typhimurium ruffling	GR00133-A-5	9.26	PSMA3 PSMB3
5	Downregulation of NFkappaB pathway	GR00313-A	9.16	POMP PSMB3
6	HIV Rev nuclear localization	GR00247-A-3	8.62	POMP PSMB3

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Drugs & Therapeutics for Nodular Episcleritis

Search Clinical Trials , NIH Clinical Center for Nodular Episcleritis

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Genetic Tests for Nodular Episcleritis

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Anatomical Context for Nodular Episcleritis

MalaCards organs/tissues related to Nodular Episcleritis:

⁴⁰

Eye

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Publications for Nodular Episcleritis

Articles related to Nodular Episcleritis:

(show all 28)

#	Title	Authors	PMID	Year
1	Bilateral Nodular Episcleritis: A Rare Presentation of Relapsing Polychondritis. ⁶¹	Meel R...Pushker N	33060514	2020
2	Case Report: Primary Conjunctival Non-Hodgkin Marginal Zone Lymphoma. ⁶¹	Bennett LW	30589762	2019
3	Episcleritis in a patient with mucosal melanoma treated with interferon alfa-2b and radiotherapy: a case report. ⁶¹	Yang L...Zhang Y	30579358	2018
4	An OCT Study of Anterior Nodular Episcleritis and Scleritis. ⁶¹	Christakopoulos C	28348907	2017
5	Pseudoepitheliomatous Hyperplasia as a Limbal Mass Mimicking Nodular Episcleritis. ⁶¹	Mohebbi M...Mahbod M	27051264	2016
6	Tubercular Nodular Episcleritis: A Case Report. ⁶¹	Yadav S...Rawal G	26435978	2015
7	Conjunctival Angioimmunoblastic T-Cell Lymphoma. ⁶¹	Patel DS...Mudhar HS	27231687	2015
8	[Nodular episcleritis: an unusual inaugural manifestation of Horton disease]. ⁶¹	Klii R...Chebbi W	26401214	2015
9	Nodular episcleritis after laser in situ keratomileusis in patient with systemic lupus erythematosus. ⁶¹	Al-Amry M	23772134	2013
10	Tubercular nodular episcleritis. ⁶¹	Bathula BP...Ponnamalla PK	22973786	2012
11	Clinical and radiological features of Takayasu's arteritis patients in Jordan. ⁶¹	Mustafa KN...Sweiss NJ	19862530	2010
12	Ocular manifestations associated with chikungunya. ⁶¹	Mahendradas P...Shetty BK	17631967	2008
13	Keratectasia as a presentation of surgically induced necrotizing sclerokeratitis (SINS). ⁶¹	Nguyen DQ...Luthert P	17993831	2007
14	Multifocal nodular episcleritis and scleritis with undiagnosed Hodgkin's lymphoma. ⁶¹	Thakker MM...Foster CS	12750114	2003
15	Acute febrile neutrophilic dermatosis (Sweet's syndrome) with nodular episcleritis and polyneuropathy. ⁶¹	Kato T...Endo M	11982648	2002
16	Successful treatment of ocular leishmaniasis. ⁶¹	Abrishami M...Dowlati Y	11809607	2002
17	Anterior segment indocyanine green angiography in scleral inflammation. ⁶¹	Aydin P...Kadayifcilar S	10845019	2000
18	Episcleritis in childhood. ⁶¹	Read RW...Sherry DD	10599674	1999
19	Localized transscleral staphylococcal abscess simulating a neoplasm. ⁶¹	Kiratli H...Friedberg H	7496342	1995
20	Conjunctival ulcer in a patient with Crohn's disease. ⁶¹	Hegab SM...al-Mutawa SA	7831012	1994
21	Severity of scleritis and episcleritis. ⁶¹	Sainz de la Maza M...Foster CS	8115160	1994
22	Clinical profile of herpes zoster ophthalmicus. ⁶¹	Nigam P...Mukhija RD	1748774	1991
23	Syphilitic episcleritis and scleritis. ⁶¹	Wilhelmus KR...Yokoyama CM	3688101	1987
24	Adverse reactions to virgin silk sutures in cataract surgery. ⁶¹	Soong HK...Kenyon KR	6377167	1984
25	Cogan's syndrome: a treatable cause of neurosensory deafness. ⁶¹	Bachynski B...Wise J	6610465	1984
26	Scleritis and episcleritis. ⁶¹	Watson PG...Hayreh SS	1268179	1976
27	[A case of leprous nodular episcleritis]?1. ⁶¹	Haye C...Guyot-Sionnest M	4282230	1974
28	Local use of antistine in nodular episcleritis. ⁶¹	GROSSMANN EE...LORING MJ	18135470	1949

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Genes for Nodular Episcleritis

Genes related to Nodular Episcleritis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PSMB8	Proteasome 20S Subunit Beta 8	Protein Coding	6.01	DISEASES inferred ¹⁵
2	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	5.08	DISEASES inferred ¹⁵
3	SPN	Sialophorin	Protein Coding	4.93	DISEASES inferred ¹⁵
4	POMP	Proteasome Maturation Protein	Protein Coding	4.86	DISEASES inferred ¹⁵
5	OTULIN	OTU Deubiquitinase With Linear Linkage Specificity	Protein Coding	4.74	DISEASES inferred ¹⁵
6	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	4.68	DISEASES inferred ¹⁵
7	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	4.66	DISEASES inferred ¹⁵

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Variations for Nodular Episcleritis

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Expression for Nodular Episcleritis

Search GEO for disease gene expression data for Nodular Episcleritis.

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Pathways for Nodular Episcleritis

Pathways related to Nodular Episcleritis according to GeneCards Suite gene sharing:

(show all 29)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of proteins ⁶⁵ Show member pathways Post-translational protein modification ⁶⁵	13.45	PSMB8 PSMB4 PSMB3 PSMA3 OTULIN
2	Class I MHC mediated antigen processing and presentation ⁶⁵ Show member pathways Adaptive Immune System ⁶⁵ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁵	13.12	PSMB8 PSMB4 PSMB3 PSMA3
3	Cell Cycle, Mitotic ⁶⁵ Show member pathways Cell Cycle ⁶⁵ M Phase ⁶⁵	13.1	PSMB8 PSMB4 PSMB3 PSMA3
4	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds ⁶⁵ Show member pathways Bicarbonate transporters ⁶⁵ Cation-coupled Chloride cotransporters ⁶⁵ Class II GLUTs ⁶⁵ Facilitative Na+-independent glucose transporters ⁶⁵ Inositol transporters ⁶⁵ Multifunctional anion exchangers ⁶⁵ Na+/Cl- dependent neurotransmitter transporters ⁶⁵ Na+-dependent glucose transporters ⁶⁵ Organic anion transport ⁶⁵ Organic anion transporters ⁶⁵ Organic cation transport ⁶⁵ Organic cation/anion/zwitterion transport ⁶⁵ Proton/oligopeptide cotransporters ⁶⁵ Proton-coupled monocarboxylate transport ⁶⁵ Rhesus glycoproteins mediate ammonium transport. ⁶⁵ SLC-mediated transmembrane transport ⁶⁵ Sodium/Calcium exchangers ⁶⁵ Sodium/Proton exchangers ⁶⁵ Sodium-coupled phosphate cotransporters ⁶⁵ Sodium-coupled sulphate, di- and tri-carboxylate transporters ⁶⁵ Transmembrane transport of small molecules ⁶⁵ Transport of inorganic cations/anions and amino acids/oligopeptides ⁶⁵ Type II Na+/Pi cotransporters ⁶⁵	13.06	PSMB8 PSMB4 PSMB3 PSMA3
5	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.03	PSMB8 PSMB4 PSMB3 PSMA3
6	Nanog in Mammalian ESC Pluripotency ⁶³ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶³ eNOS Signaling ⁶³ GSK3 Signaling ⁶³	12.96	PSMB8 PSMB4 PSMB3 PSMA3
7	Regulation of PLK1 Activity at G2/M Transition ⁶⁵ Show member pathways Anchoring of the basal body to the plasma membrane ⁶⁵ AURKA Activation by TPX2 ⁶⁵ Centrosome maturation ⁶⁵ G2/M Transition ⁶⁵ Interaction between PHLDA1 and AURKA ⁶⁵ Loss of Nlp from mitotic centrosomes ⁶⁵ Loss of proteins required for interphase microtubule organization from the centrosome ⁶⁵ Mitotic G2-G2/M phases ⁶⁵ Polo-like kinase mediated events ⁶⁵ Recruitment of mitotic centrosome proteins and complexes ⁶⁵ Recruitment of NuMA to mitotic centrosomes ⁶⁵	12.89	PSMB8 PSMB4 PSMB3 PSMA3
8	Cellular Senescence (REACTOME) ⁶⁵ Show member pathways Cellular responses to stress ⁶⁵ Cellular Senescence ⁶⁵ Oxidative Stress Induced Senescence ⁶⁵	12.85	PSMB8 PSMB4 PSMB3 PSMA3
9	fMLP Pathway ⁶³ Show member pathways Alpha-Adrenergic Signaling ⁶³ CCR3 Pathway in Eosinophils ⁶³ CXCR4 Pathway ⁶³ Huntington's Disease Pathway ⁶³ Internalin Pathway ⁶³ Signal transduction Activation of PKC via G-Protein coupled receptor ²³ VEGF and S-1P Signaling ⁶³	12.73	PSMB8 PSMB4 PSMB3 PSMA3
10	Signaling by Wnt ⁶⁵ Show member pathways TCF dependent signaling in response to WNT ⁶⁵	12.64	PSMB8 PSMB4 PSMB3 PSMA3
11	Mitotic Metaphase and Anaphase ⁶⁵ Show member pathways Mitotic Anaphase ⁶⁵ Separation of Sister Chromatids ⁶⁵	12.58	PSMB8 PSMB4 PSMB3 PSMA3
12	Deubiquitination ⁶⁵ Show member pathways Ub-specific processing proteases ⁶⁵	12.57	PSMB8 PSMB4 PSMB3 PSMA3
13	Beta-Adrenergic Signaling ⁶³ Show member pathways CDK5 Pathway ⁶³ Erythropoietin Pathway ⁶³ Insulin Receptor Pathway ⁶³	12.54	PSMB8 PSMB4 PSMB3 PSMA3
14	Prion disease ³⁶ Show member pathways Parkinson disease ³⁶	12.53	PSMB4 PSMB3 PSMA3
15	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.44	PSMB8 PSMB4 PSMB3 PSMA3
16	Chks in Checkpoint Regulation ⁶³ Show member pathways DNA Repair Mechanisms ⁶³ Estrogen-mediated S-Phase Entry ⁶³ G2-M Phase Transition ⁶³ Parkinson's Disease Pathway ⁶³ SREBP Proteolysis ⁶³	12.42	PSMB8 PSMB4 PSMB3 PSMA3
17	Cell Cycle Checkpoints ⁶⁵ Show member pathways G2/M Checkpoints ⁶⁵	12.33	PSMB8 PSMB4 PSMB3 PSMA3
18	Signaling by Hedgehog ⁶⁵ Show member pathways Activation of SMO ⁶⁵ Hedgehog off' state ⁶⁵ Hedgehog on' state ⁶⁵	12.27	PSMB8 PSMB4 PSMB3 PSMA3
19	Mitotic G1-G1/S phases ⁶⁵ Show member pathways G1 to S cell cycle control ¹ G1/S Transition ⁶⁵	12.22	PSMB8 PSMB4 PSMB3 PSMA3
20	Antigen processing-Cross presentation ⁶⁵ Show member pathways Cross-presentation of particulate exogenous antigens (phagosomes) ⁶⁵ Endosomal/Vacuolar pathway ⁶⁵ ER-Phagosome pathway ⁶⁵ Immune response Antigen presentation by MHC class I ²³	12.12	PSMB8 PSMB4 PSMB3 PSMA3
21	p53 Signaling ⁶³ Show member pathways P53 Pathway ⁶⁶	12.04	PSMB4 PSMB3 PSMA3
22	WNT Signaling ⁶³	12.02	PSMB8 PSMB4 PSMB3 PSMA3
23	CLEC7A (Dectin-1) signaling ⁶⁵ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁵ C-type lectin receptors (CLRs) ⁶⁵	11.97	PSMB8 PSMB4 PSMB3 PSMA3
24	Spinocerebellar ataxia ³⁶	11.9	PSMB4 PSMB3 PSMA3
25	TCR signaling (REACTOME) ⁶⁵ Show member pathways Downstream TCR signaling ⁶⁵	11.81	PSMB8 PSMB4 PSMB3 PSMA3
26	Ubiquitin-Proteasome Dependent Proteolysis ⁶³	11.8	PSMB4 PSMB3 PSMA3
27	Regulation of degradation of deltaF508 CFTR in CF ²³ Show member pathways Regulation of degradation of wt-CFTR ²³	11.65	PSMB4 PSMB3 PSMA3
28	Presenilin-Mediated Signaling ⁶³	11.08	PSMB8 PSMB4 PSMB3 PSMA3
29	Transcription_P53 signaling pathway ²³	10.99	PSMB8 PSMB4 PSMB3 PSMA3

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GO Terms for Nodular Episcleritis

Cellular components related to Nodular Episcleritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:0005829	9.8	PSMB8 PSMB4 PSMB3 PSMA3 POMP OTULIN
2	extracellular exosome	GO:0070062	9.65	SPN PSMB8 PSMB4 PSMB3 PSMA3
3	proteasome core complex, beta-subunit complex	GO:0019774	9.33	PSMB8 PSMB4 PSMB3
4	proteasome complex	GO:0000502	9.26	PSMB8 PSMB4 PSMB3 PSMA3
5	proteasome core complex	GO:0005839	8.92	PSMB8 PSMB4 PSMB3 PSMA3

Biological processes related to Nodular Episcleritis according to GeneCards Suite gene sharing:

(show all 29)

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane transport	GO:0055085	9.94	PSMB8 PSMB4 PSMB3 PSMA3
2	proteolysis	GO:0006508	9.94	PSMB8 PSMB4 PSMB3 OTULIN
3	viral process	GO:0016032	9.93	PSMB8 PSMB4 PSMB3 PSMA3
4	post-translational protein modification	GO:0043687	9.92	PSMB8 PSMB4 PSMB3 PSMA3
5	MAPK cascade	GO:0000165	9.92	PSMB8 PSMB4 PSMB3 PSMA3
6	protein polyubiquitination	GO:0000209	9.91	PSMB8 PSMB4 PSMB3 PSMA3
7	protein deubiquitination	GO:0016579	9.91	PSMB8 PSMB4 PSMB3 PSMA3
8	proteasome-mediated ubiquitin-dependent protein catabolic process	GO:0043161	9.9	PSMB8 PSMB4 PSMB3 PSMA3
9	negative regulation of canonical Wnt signaling pathway	GO:0090090	9.89	PSMB8 PSMB4 PSMB3 PSMA3
10	T cell receptor signaling pathway	GO:0050852	9.88	PSMB8 PSMB4 PSMB3 PSMA3
11	Fc-epsilon receptor signaling pathway	GO:0038095	9.88	PSMB8 PSMB4 PSMB3 PSMA3
12	positive regulation of canonical Wnt signaling pathway	GO:0090263	9.87	PSMB8 PSMB4 PSMB3 PSMA3
13	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.86	PSMB8 PSMB4 PSMB3 PSMA3
14	regulation of mRNA stability	GO:0043488	9.85	PSMB8 PSMB4 PSMB3 PSMA3
15	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.84	PSMB8 PSMB4 PSMB3 PSMA3
16	interleukin-1-mediated signaling pathway	GO:0070498	9.83	PSMB8 PSMB4 PSMB3 PSMA3
17	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:0031146	9.81	PSMB8 PSMB4 PSMB3 PSMA3
18	Wnt signaling pathway, planar cell polarity pathway	GO:0060071	9.8	PSMB8 PSMB4 PSMB3 PSMA3
19	anaphase-promoting complex-dependent catabolic process	GO:0031145	9.78	PSMB8 PSMB4 PSMB3 PSMA3
20	regulation of mitotic cell cycle phase transition	GO:1901990	9.76	PSMB8 PSMB4 PSMB3 PSMA3
21	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:0002479	9.73	PSMB8 PSMB4 PSMB3 PSMA3
22	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:0061418	9.71	PSMB8 PSMB4 PSMB3 PSMA3
23	NIK/NF-kappaB signaling	GO:0038061	9.67	PSMB8 PSMB4 PSMB3 PSMA3
24	regulation of endopeptidase activity	GO:0052548	9.63	PSMB8 PSMA3
25	regulation of hematopoietic stem cell differentiation	GO:1902036	9.62	PSMB8 PSMB4 PSMB3 PSMA3
26	negative regulation of G2/M transition of mitotic cell cycle	GO:0010972	9.56	PSMB8 PSMB4 PSMB3 PSMA3
27	proteolysis involved in cellular protein catabolic process	GO:0051603	9.46	PSMB8 PSMB4 PSMB3 PSMA3
28	regulation of cellular amino acid metabolic process	GO:0006521	9.26	PSMB8 PSMB4 PSMB3 PSMA3
29	proteasomal ubiquitin-independent protein catabolic process	GO:0010499	8.92	PSMB8 PSMB4 PSMB3 PSMA3

Molecular functions related to Nodular Episcleritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidase activity	GO:0008233	9.46	PSMB8 PSMB4 PSMB3 OTULIN
2	endopeptidase activity	GO:0004175	9.26	PSMB8 PSMB4 PSMB3 PSMA3
3	threonine-type endopeptidase activity	GO:0004298	8.8	PSMB8 PSMB4 PSMB3

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Sources for Nodular Episcleritis

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