MCID: NDL011
MIFTS: 34

Nodular Ganglioneuroblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Nodular Ganglioneuroblastoma

MalaCards integrated aliases for Nodular Ganglioneuroblastoma:

Name: Nodular Ganglioneuroblastoma 12 15
Ganglioneuroblastoma, Nodular 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5193
NCIt 50 C42058
UMLS 73 C1517445

Summaries for Nodular Ganglioneuroblastoma

MalaCards based summary : Nodular Ganglioneuroblastoma, also known as ganglioneuroblastoma, nodular, is related to ganglioneuroblastoma and neuroblastoma. An important gene associated with Nodular Ganglioneuroblastoma is MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Akt Signaling and PI3K-Akt signaling pathway. Affiliated tissues include lung, brain and bone, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Nodular Ganglioneuroblastoma

Diseases related to Nodular Ganglioneuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 ganglioneuroblastoma 30.3 ENO2 MYCN NTRK2 SYP
2 neuroblastoma 28.7 ALK BDNF ENO2 MDM2 MYCN NTRK2
3 pericardium cancer 10.3 MYCN ENO2
4 extraosseous ewing's sarcoma 10.3 MYCN ENO2
5 adrenal neuroblastoma 10.2 ENO2 MYCN
6 gastric neuroendocrine neoplasm 10.2 ATRX CHGA
7 intracranial primitive neuroectodermal tumor 10.2 CHGA ENO2
8 askin's tumor 10.2 ENO2 MYCN
9 somatostatinoma 10.2 ENO2 CHGA
10 epithelioid malignant peripheral nerve sheath tumor 10.2 CHGA ENO2
11 lung oat cell carcinoma 10.2 CHGA ENO2
12 goblet cell carcinoid 10.2 CHGA ENO2
13 acute thyroiditis 10.2 CHGA ENO2
14 adenosquamous lung carcinoma 10.2 ENO2 ALK
15 tracheoesophageal fistula 10.2 SYP MYCN
16 conventional fibrosarcoma 10.2 ENO2 MDM2
17 tubular adenocarcinoma 10.2 SYP CHGA
18 gastric tubular adenocarcinoma 10.2 SYP CHGA
19 duodenal gastrinoma 10.1 ENO2 CHGA
20 retroperitoneal neuroblastoma 10.1 CDKN1A ENO2
21 desmoplastic infantile ganglioglioma 10.1 MYCN SYP
22 malignant mesenchymoma 10.1 MDM2 CDKN1A
23 urethral benign neoplasm 10.1 CHGA ALK
24 ureter small cell carcinoma 10.1 CHGA SYP
25 chondrosarcoma, extraskeletal myxoid 10.1 SYP ENO2
26 esophageal neuroendocrine tumor 10.1 CHGA SYP
27 chondroid lipoma 10.1 MDM2 ENO2
28 adrenal rest tumor 10.1 SYP ENO2
29 ovarian large-cell neuroendocrine carcinoma 10.1 CHGA SYP
30 optic nerve glioma 10.1 SYP ENO2
31 adenoma of the pancreas 10.1 CHGA SYP
32 acinar cell cystadenocarcinoma 10.1 CHGA SYP
33 peritoneal serous adenocarcinoma 10.1 CHGA SYP
34 cellular ependymoma 10.1 CHGA SYP
35 nervous system benign neoplasm 10.1 SYP ENO2
36 primary hepatic neuroendocrine carcinoma 10.1 CHGA SYP
37 spinal meningioma 10.1 CHGA ENO2
38 chordoid meningioma 10.1 CHGA SYP
39 spinal canal and spinal cord meningioma 10.1 CHGA ENO2
40 olfactory groove meningioma 10.1 CHGA SYP
41 carotid body cancer 10.1 ENO2 SYP
42 actinic cheilitis 10.1 CDKN1A MDM2
43 malignant sertoli cell tumor 10.1 ENO2 SYP
44 pancreatic serous cystadenoma 10.1 CHGA SYP
45 heart sarcoma 10.1 MDM2 ENO2
46 sinonasal undifferentiated carcinoma 10.1 ENO2 SYP
47 cystadenoma 10.1 SYP CHGA
48 conventional angiosarcoma 10.1 CHGA SYP
49 pancreatic somatostatinoma 10.1 ENO2 SYP
50 cutaneous ganglioneuroma 10.1 ENO2 SYP

Graphical network of the top 20 diseases related to Nodular Ganglioneuroblastoma:



Diseases related to Nodular Ganglioneuroblastoma

Symptoms & Phenotypes for Nodular Ganglioneuroblastoma

MGI Mouse Phenotypes related to Nodular Ganglioneuroblastoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.15 ALK ATRX BDNF CDKN1A ENO2 MDM2
2 growth/size/body region MP:0005378 10.06 ALK ATRX BDNF CDKN1A CHGA ENO2
3 cellular MP:0005384 10.02 ATRX BDNF CDKN1A ENO2 MDM2 MYCN
4 nervous system MP:0003631 10.02 ALK ATRX BDNF CDKN1A CHGA ENO2
5 mortality/aging MP:0010768 9.97 ALK ATRX BDNF CDKN1A CHGA MDM2
6 endocrine/exocrine gland MP:0005379 9.91 ALK BDNF CDKN1A CHGA MDM2 NTRK2
7 craniofacial MP:0005382 9.85 BDNF CDKN1A ENO2 MDM2 MYCN
8 reproductive system MP:0005389 9.76 ALK ATRX BDNF CDKN1A CHGA MDM2
9 no phenotypic analysis MP:0003012 9.65 BDNF CDKN1A CHGA MDM2 MYCN
10 respiratory system MP:0005388 9.43 ALK BDNF CDKN1A ENO2 MYCN NTRK2
11 vision/eye MP:0005391 9.1 ALK ATRX BDNF CDKN1A MYCN NTRK2

Drugs & Therapeutics for Nodular Ganglioneuroblastoma

Search Clinical Trials , NIH Clinical Center for Nodular Ganglioneuroblastoma

Genetic Tests for Nodular Ganglioneuroblastoma

Anatomical Context for Nodular Ganglioneuroblastoma

MalaCards organs/tissues related to Nodular Ganglioneuroblastoma:

41
Lung, Brain, Bone, Heart, Spinal Cord, Pineal, Cerebellum

Publications for Nodular Ganglioneuroblastoma

Articles related to Nodular Ganglioneuroblastoma:

# Title Authors Year
1
The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins. ( 25081755 )
2014
2
Large mediastinal nodular ganglioneuroblastoma in a child from Africa. ( 23080230 )
2012
3
Nodular ganglioneuroblastoma in adults. ( 19680497 )
2009
4
Expression of brain-derived neurotrophic factor and tropomyosin-related kinase-B in a bovine jejunal nodular ganglioneuroblastoma. ( 18487493 )
2008

Variations for Nodular Ganglioneuroblastoma

Expression for Nodular Ganglioneuroblastoma

Search GEO for disease gene expression data for Nodular Ganglioneuroblastoma.

Pathways for Nodular Ganglioneuroblastoma

Pathways related to Nodular Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 ALK BDNF CDKN1A MDM2 NTRK2
2
Show member pathways
12.57 BDNF CDKN1A MDM2 NTRK2
3 11.77 CDKN1A MDM2 MYCN
4 11.59 CDKN1A MDM2 NTRK2
5 11.46 ENO2 MYCN NTRK2 SYP
6 10.9 BDNF NTRK2
7
Show member pathways
10.5 CDKN1A MDM2
8 10.1 BDNF NTRK2

GO Terms for Nodular Ganglioneuroblastoma

Cellular components related to Nodular Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 8.92 BDNF CDKN1A CHGA NTRK2

Biological processes related to Nodular Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.62 ALK CDKN1A MDM2 NTRK2
2 activation of phospholipase C activity GO:0007202 9.37 BDNF NTRK2
3 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.33 ALK BDNF NTRK2
4 neurotrophin TRK receptor signaling pathway GO:0048011 9.26 BDNF NTRK2
5 positive regulation of non-membrane spanning protein tyrosine kinase activity GO:1903997 8.96 BDNF NTRK2
6 brain-derived neurotrophic factor receptor signaling pathway GO:0031547 8.62 BDNF NTRK2

Sources for Nodular Ganglioneuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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