MCID: NDL011
MIFTS: 27

Nodular Ganglioneuroblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Nodular Ganglioneuroblastoma

MalaCards integrated aliases for Nodular Ganglioneuroblastoma:

Name: Nodular Ganglioneuroblastoma 12 15
Ganglioneuroblastoma, Nodular 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5193
NCIt 50 C42058
SNOMED-CT 67 822950002
UMLS 70 C1517445

Summaries for Nodular Ganglioneuroblastoma

MalaCards based summary : Nodular Ganglioneuroblastoma, also known as ganglioneuroblastoma, nodular, is related to ganglioneuroblastoma and ganglioneuroma. An important gene associated with Nodular Ganglioneuroblastoma is MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways is Neuroscience. The drugs Sargramostim and Irinotecan have been mentioned in the context of this disorder. Affiliated tissues include lung, appendix and brain, and related phenotype is respiratory system.

Related Diseases for Nodular Ganglioneuroblastoma

Diseases related to Nodular Ganglioneuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 ganglioneuroblastoma 30.0 NTRK2 MYCN ENO2 ALK
2 ganglioneuroma 29.3 NTRK2 MYCN ENO2 CHGA
3 neuroblastoma 28.2 NTRK2 NBL1 MYCNOS MYCN ENO2 CHGA
4 retroperitoneal neuroblastoma 10.2 MYCN ENO2
5 frontal lobe neoplasm 10.2 MYCN ENO2
6 malignant giant cell tumor of the tendon sheath 10.1 NTRK2 ALK
7 horner's syndrome 10.1 MYCN ENO2
8 cerebellum cancer 10.1 MYCN ENO2
9 central nervous system primitive neuroectodermal neoplasm 10.1 MYCN ENO2
10 ependymoblastoma 10.1 MYCN ENO2
11 pediatric fibrosarcoma 10.1 NTRK2 ALK
12 cerebral ventricle cancer 10.1 MYCN ENO2
13 paratesticular lipoma 10.1 ENO2 ALK
14 congenital fibrosarcoma 10.1 NTRK2 ALK
15 lipoma of spermatic cord 10.1 ENO2 ALK
16 cerebrum cancer 10.1 MYCN ENO2
17 supratentorial cancer 10.1 MYCN ENO2
18 pulmonary large cell neuroendocrine carcinoma 10.0 CHGA ALK
19 vaginal glandular tumor 10.0 ENO2 CHGA
20 ureter transitional cell carcinoma 10.0 ENO2 CHGA
21 auditory system benign neoplasm 10.0 ENO2 CHGA
22 auditory system cancer 10.0 ENO2 CHGA
23 gastric gastrinoma 10.0 ENO2 CHGA
24 cauda equina neoplasm 10.0 ENO2 CHGA
25 lymphoepithelioma-like carcinoma 10.0 ENO2 ALK
26 ampulla of vater benign neoplasm 10.0 ENO2 CHGA
27 appendix carcinoid tumor 10.0 ENO2 CHGA
28 carotid body cancer 10.0 ENO2 CHGA
29 gallbladder small cell carcinoma 10.0 ENO2 CHGA
30 ureter small cell carcinoma 10.0 ENO2 CHGA
31 middle ear adenoma 10.0 ENO2 CHGA
32 goblet cell carcinoid 10.0 ENO2 CHGA
33 urinary bladder small cell neuroendocrine carcinoma 10.0 ENO2 CHGA
34 gastric small cell carcinoma 10.0 ENO2 CHGA
35 ewing sarcoma of bone 10.0 ENO2 CHGA
36 sensory organ benign neoplasm 10.0 ENO2 CHGA
37 ovarian large-cell neuroendocrine carcinoma 10.0 ENO2 CHGA
38 gastric hemangioma 10.0 ENO2 CHGA
39 appendix lymphoma 10.0 ENO2 CHGA
40 subependymoma 10.0 ENO2 CHGA
41 pineocytoma 10.0 ENO2 CHGA
42 cutaneous ganglioneuroma 10.0 ENO2 CHGA
43 cervix small cell carcinoma 10.0 ENO2 CHGA
44 gastrointestinal neuroendocrine tumor 10.0 ENO2 CHGA
45 carcinoid tumors, intestinal 10.0 ENO2 CHGA
46 endometrial small cell carcinoma 10.0 ENO2 CHGA
47 colon neuroendocrine neoplasm 10.0 ENO2 CHGA
48 carcinoid syndrome 10.0 ENO2 CHGA
49 liver leiomyosarcoma 10.0 ENO2 CHGA
50 small intestine benign neoplasm 10.0 ENO2 CHGA

Graphical network of the top 20 diseases related to Nodular Ganglioneuroblastoma:



Diseases related to Nodular Ganglioneuroblastoma

Symptoms & Phenotypes for Nodular Ganglioneuroblastoma

MGI Mouse Phenotypes related to Nodular Ganglioneuroblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.02 ALK ENO2 MYCN NTRK2 SESN2

Drugs & Therapeutics for Nodular Ganglioneuroblastoma

Drugs for Nodular Ganglioneuroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
2
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
3
Isotretinoin Approved Phase 2 4759-48-2 5538 5282379
4
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
5
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
6
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 11103-57-4 445354
7
Molgramostim Investigational Phase 2 99283-10-0
8 Micronutrients Phase 2
9 topoisomerase I inhibitors Phase 2
10 Retinol palmitate Phase 2
11 Trace Elements Phase 2
12 Nutrients Phase 2
13 Ch14.18 monoclonal antibody Phase 2
14 Immunoglobulins Phase 2
15 retinol Phase 2
16 Alkylating Agents Phase 2
17 Vitamins Phase 2
18 Antibodies, Monoclonal Phase 2
19 Antibodies Phase 2
20 Immunologic Factors Phase 2
21 Dermatologic Agents Phase 2
22 Keratolytic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Pilot Study of Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination With Irinotecan and Temozolomide in the Post-Consolidation Setting for High-Risk Neuroblastoma Recruiting NCT04385277 Phase 2 Irinotecan;Isotretinoin;Temozolomide

Search NIH Clinical Center for Nodular Ganglioneuroblastoma

Genetic Tests for Nodular Ganglioneuroblastoma

Anatomical Context for Nodular Ganglioneuroblastoma

MalaCards organs/tissues related to Nodular Ganglioneuroblastoma:

40
Lung, Appendix, Brain, Bone, Cerebellum, Skeletal Muscle, Small Intestine

Publications for Nodular Ganglioneuroblastoma

Articles related to Nodular Ganglioneuroblastoma:

(show all 30)
# Title Authors PMID Year
1
Importance of Magnetic Resonance Imaging With Diffusion-weighted Imaging in Guiding Biopsy of Nodular Ganglioneuroblastoma: A Case Report. 61
31815883 2021
2
High Oct4 expression: implications in the pathogenesis of neuroblastic tumours. 61
30606139 2019
3
Usefulness of fluorodeoxyglucose positron emission tomography/computed tomography for detection of a neuroblastic nodule in a ganglioneuroblastoma: a case report. 61
29720264 2018
4
Cervical ganglioneuroblastoma in a new born Japanese Black calf. 61
29526867 2018
5
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours. 61
28477311 2017
6
Clinical and biological features of neuroblastic tumors: A comparison of neuroblastoma and ganglioneuroblastoma. 61
28465480 2017
7
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed. 61
27465021 2016
8
Genetic abnormalities in adolescents and young adults with neuroblastoma: A report from the Italian Neuroblastoma group. 61
25925003 2015
9
The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins. 61
25081755 2015
10
Neuroblastoma in the adult: the Italian experience with 21 patients. 61
24633299 2014
11
Two cases of neuroblastoma comprising two distinct clones. 61
24108545 2014
12
High incidence of MYCN amplification in a Moroccan series of neuroblastic tumors: comparison to current biological data. 61
23628823 2013
13
[Clinicopathologic features of peripheral neuroblastic tumors]. 61
24004586 2013
14
Large mediastinal nodular ganglioneuroblastoma in a child from Africa. 61
23080230 2012
15
Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: a report from the INRG project. 61
22137163 2012
16
[Correlation between typing of peripheral neuroblastic tumors and prognosis: a clinicopathologic study of 135 cases]. 61
21575383 2011
17
Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG. 61
19530234 2009
18
Nodular ganglioneuroblastoma in adults. 61
19680497 2009
19
Expression of brain-derived neurotrophic factor and tropomyosin-related kinase-B in a bovine jejunal nodular ganglioneuroblastoma. 61
18487493 2008
20
Retroperitoneal ganglioneuroblastoma resected 8 years after mass screening: a case report. 61
18022424 2007
21
A case of composite neuroblastoma composed of histologically and biologically distinct clones. 61
17535087 2007
22
International neuroblastoma pathology classification adds independent prognostic information beyond the prognostic contribution of age. 61
16624549 2006
23
Large cell neuroblastoma: a distinct phenotype of neuroblastoma with aggressive clinical behavior. 61
14716776 2004
24
Revision of the International Neuroblastoma Pathology Classification: confirmation of favorable and unfavorable prognostic subsets in ganglioneuroblastoma, nodular. 61
14601099 2003
25
International neuroblastoma pathology classification for prognostic evaluation of patients with peripheral neuroblastic tumors: a report from the Children's Cancer Group. 61
11745303 2001
26
Histopathology (International Neuroblastoma Pathology Classification) and MYCN status in patients with peripheral neuroblastic tumors: a report from the Children's Cancer Group. 61
11745206 2001
27
p53 cellular localization and function in neuroblastoma: evidence for defective G(1) arrest despite WAF1 induction in MYCN-amplified cells. 61
11395384 2001
28
Histopathology defines prognostic subsets of ganglioneuroblastoma, nodular. 61
10964346 2000
29
The International Neuroblastoma Pathology Classification (the Shimada system). 61
10421273 1999
30
Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee. 61
10421272 1999

Variations for Nodular Ganglioneuroblastoma

Expression for Nodular Ganglioneuroblastoma

Search GEO for disease gene expression data for Nodular Ganglioneuroblastoma.

Pathways for Nodular Ganglioneuroblastoma

Pathways related to Nodular Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 NTRK2 MYCN ENO2

GO Terms for Nodular Ganglioneuroblastoma

Biological processes related to Nodular Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of kinase activity GO:0033674 8.96 NTRK2 ALK
2 cellular response to amino acid stimulus GO:0071230 8.62 SESN2 NTRK2

Molecular functions related to Nodular Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 NTRK2 ALK

Sources for Nodular Ganglioneuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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