MCID: NDL011
MIFTS: 28

Nodular Ganglioneuroblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Nodular Ganglioneuroblastoma

MalaCards integrated aliases for Nodular Ganglioneuroblastoma:

Name: Nodular Ganglioneuroblastoma 12 15
Ganglioneuroblastoma, Nodular 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5193
NCIt 50 C42058
UMLS 73 C1517445

Summaries for Nodular Ganglioneuroblastoma

MalaCards based summary : Nodular Ganglioneuroblastoma, also known as ganglioneuroblastoma, nodular, is related to ganglioneuroblastoma and neuroblastoma. An important gene associated with Nodular Ganglioneuroblastoma is MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Akt Signaling and PI3K-Akt signaling pathway. Related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Nodular Ganglioneuroblastoma

Diseases related to Nodular Ganglioneuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 ganglioneuroblastoma 29.6 ENO2 MYCN NTRK2 SYP
2 neuroblastoma 25.9 ALK BDNF ENO2 MDM2 MYCN NTRK2
3 gastric neuroendocrine neoplasm 10.8 ATRX CHGA
4 adrenal neuroblastoma 10.8 ENO2 MYCN
5 intracranial primitive neuroectodermal tumor 10.7 CHGA ENO2
6 askin's tumor 10.7 ENO2 MYCN
7 epithelioid malignant peripheral nerve sheath tumor 10.7 CHGA ENO2
8 goblet cell carcinoid 10.7 CHGA ENO2
9 acute thyroiditis 10.7 CHGA ENO2
10 somatostatinoma 10.6 CHGA ENO2
11 duodenal gastrinoma 10.6 CHGA ENO2
12 spinal meningioma 10.6 CHGA ENO2
13 spinal canal and spinal cord meningioma 10.6 CHGA ENO2
14 conventional fibrosarcoma 10.5 ENO2 MDM2
15 bone ewing's sarcoma 10.5 ENO2 MYCN
16 diffuse pulmonary fibrosis 10.5 CHGA ENO2
17 pericardium cancer 10.5 ENO2 MYCN
18 chondroid lipoma 10.5 ENO2 MDM2
19 retroperitoneal neuroblastoma 10.5 CDKN1A ENO2
20 neonatal hypoxic and ischemic brain injury 10.5 BDNF ENO2
21 desmoplastic infantile ganglioglioma 10.5 MYCN SYP
22 heart sarcoma 10.5 ENO2 MDM2
23 esophageal neuroendocrine tumor 10.5 CHGA SYP
24 adult astrocytic tumour 10.4 ATRX BDNF
25 ovarian large-cell neuroendocrine carcinoma 10.4 CHGA SYP
26 adenoma of the pancreas 10.4 CHGA SYP
27 acinar cell cystadenocarcinoma 10.4 CHGA SYP
28 peritoneal serous adenocarcinoma 10.4 CHGA SYP
29 cellular ependymoma 10.4 CHGA SYP
30 primary hepatic neuroendocrine carcinoma 10.4 CHGA SYP
31 chordoid meningioma 10.4 CHGA SYP
32 pancreatic serous cystadenoma 10.4 CHGA SYP
33 conventional angiosarcoma 10.4 CHGA SYP
34 actinic cheilitis 10.4 CDKN1A MDM2
35 malignant sertoli cell tumor 10.4 ENO2 SYP
36 sinonasal undifferentiated carcinoma 10.4 ENO2 SYP
37 sensory organ benign neoplasm 10.4 ENO2 SYP
38 pulmonary sclerosing hemangioma 10.4 CHGA SYP
39 pancreatoblastoma 10.4 CHGA SYP
40 pancreatic somatostatinoma 10.4 ENO2 SYP
41 cutaneous ganglioneuroma 10.4 ENO2 SYP
42 extrahepatic bile duct adenocarcinoma 10.4 ENO2 SYP
43 papillary tumor of the pineal region 10.4 ENO2 SYP
44 orbital cancer 10.4 ENO2 SYP
45 middle ear adenoma 10.4 ENO2 SYP
46 ovarian carcinosarcoma 10.4 ENO2 SYP
47 pulmonary blastoma 10.3 CHGA SYP
48 central nervous system primitive neuroectodermal neoplasm 10.3 ENO2 SYP
49 cerebellum cancer 10.3 ENO2 SYP
50 subependymal glioma 10.3 ENO2 SYP

Graphical network of the top 20 diseases related to Nodular Ganglioneuroblastoma:



Diseases related to Nodular Ganglioneuroblastoma

Symptoms & Phenotypes for Nodular Ganglioneuroblastoma

MGI Mouse Phenotypes related to Nodular Ganglioneuroblastoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.15 ATRX ENO2 BDNF MDM2 CDKN1A ALK
2 growth/size/body region MP:0005378 10.06 ALK CHGA ATRX ENO2 BDNF MDM2
3 cellular MP:0005384 10.02 CDKN1A ATRX ENO2 BDNF MYCN NTRK2
4 mortality/aging MP:0010768 9.97 CDKN1A ALK CHGA ATRX BDNF MDM2
5 nervous system MP:0003631 9.97 ALK ATRX ENO2 BDNF MDM2 CDKN1A
6 endocrine/exocrine gland MP:0005379 9.91 CDKN1A ALK CHGA BDNF MDM2 NTRK2
7 craniofacial MP:0005382 9.85 CDKN1A ENO2 BDNF MDM2 MYCN
8 reproductive system MP:0005389 9.76 ATRX CHGA BDNF MDM2 CDKN1A ALK
9 no phenotypic analysis MP:0003012 9.65 CDKN1A CHGA BDNF MDM2 MYCN
10 respiratory system MP:0005388 9.43 ALK ENO2 BDNF CDKN1A MYCN NTRK2
11 vision/eye MP:0005391 9.1 CDKN1A ALK ATRX BDNF MYCN NTRK2

Drugs & Therapeutics for Nodular Ganglioneuroblastoma

Search Clinical Trials , NIH Clinical Center for Nodular Ganglioneuroblastoma

Genetic Tests for Nodular Ganglioneuroblastoma

Anatomical Context for Nodular Ganglioneuroblastoma

Publications for Nodular Ganglioneuroblastoma

Articles related to Nodular Ganglioneuroblastoma:

# Title Authors Year
1
The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins. ( 25081755 )
2014
2
Large mediastinal nodular ganglioneuroblastoma in a child from Africa. ( 23080230 )
2012
3
Nodular ganglioneuroblastoma in adults. ( 19680497 )
2009
4
Expression of brain-derived neurotrophic factor and tropomyosin-related kinase-B in a bovine jejunal nodular ganglioneuroblastoma. ( 18487493 )
2008

Variations for Nodular Ganglioneuroblastoma

Expression for Nodular Ganglioneuroblastoma

Search GEO for disease gene expression data for Nodular Ganglioneuroblastoma.

Pathways for Nodular Ganglioneuroblastoma

Pathways related to Nodular Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 ALK BDNF CDKN1A MDM2 NTRK2
2
Show member pathways
12.53 BDNF CDKN1A MDM2 NTRK2
3 11.7 CDKN1A MDM2 MYCN
4 11.65 CDKN1A MDM2 NTRK2
5 11.46 ENO2 MYCN NTRK2 SYP
6 10.9 BDNF NTRK2
7
Show member pathways
10.5 CDKN1A MDM2
8 10.1 BDNF NTRK2

GO Terms for Nodular Ganglioneuroblastoma

Biological processes related to Nodular Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.5 CDKN1A MDM2 MYCN
2 negative regulation of apoptotic process GO:0043066 9.46 ALK CDKN1A MDM2 NTRK2
3 cellular response to organic substance GO:0071310 9.37 MDM2 SYP
4 cellular response to gamma radiation GO:0071480 9.26 CDKN1A MDM2
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.13 ALK BDNF NTRK2
6 brain-derived neurotrophic factor receptor signaling pathway GO:0031547 8.62 BDNF NTRK2

Sources for Nodular Ganglioneuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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