MCID: NDL011
MIFTS: 31

Nodular Ganglioneuroblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Nodular Ganglioneuroblastoma

MalaCards integrated aliases for Nodular Ganglioneuroblastoma:

Name: Nodular Ganglioneuroblastoma 12 15
Ganglioneuroblastoma, Nodular 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5193
NCIt 51 C42058
UMLS 74 C1517445

Summaries for Nodular Ganglioneuroblastoma

MalaCards based summary : Nodular Ganglioneuroblastoma, also known as ganglioneuroblastoma, nodular, is related to ganglioneuroblastoma and pericardium cancer. An important gene associated with Nodular Ganglioneuroblastoma is MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Transcriptional misregulation in cancer and AKT Signaling Pathway. Affiliated tissues include brain, pineal and bone, and related phenotypes are behavior/neurological and cellular

Related Diseases for Nodular Ganglioneuroblastoma

Diseases related to Nodular Ganglioneuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 ganglioneuroblastoma 30.2 ENO2 MYCN NTRK2 SYP
2 pericardium cancer 10.4 ENO2 MYCN
3 adrenal neuroblastoma 10.4 ENO2 MYCN
4 intracranial primitive neuroectodermal tumor 10.4 CHGA ENO2
5 gastric neuroendocrine neoplasm 10.4 ATRX CHGA
6 somatostatinoma 10.4 CHGA ENO2
7 askin's tumor 10.4 ENO2 MYCN
8 epithelioid malignant peripheral nerve sheath tumor 10.4 CHGA ENO2
9 lung oat cell carcinoma 10.3 CHGA ENO2
10 goblet cell carcinoid 10.3 CHGA ENO2
11 germ cell and embryonal cancer 10.3 ENO2 POU5F1
12 acute thyroiditis 10.3 CHGA ENO2
13 traumatic brain injury 10.3 BDNF ENO2
14 drug-induced hearing loss 10.3 BDNF NTRK2
15 paranoid schizophrenia 10.3 BDNF NTRK2
16 conventional fibrosarcoma 10.3 ENO2 MDM2
17 tubular adenocarcinoma 10.2 CHGA SYP
18 gastric tubular adenocarcinoma 10.2 CHGA SYP
19 duodenal gastrinoma 10.2 CHGA ENO2
20 retroperitoneal neuroblastoma 10.2 CDKN1A ENO2
21 neonatal hypoxic and ischemic brain injury 10.2 BDNF ENO2
22 desmoplastic infantile ganglioglioma 10.2 MYCN SYP
23 chondroid lipoma 10.2 ENO2 MDM2
24 optic nerve neoplasm 10.2 ENO2 SYP
25 ureter small cell carcinoma 10.2 CHGA SYP
26 esophageal neuroendocrine tumor 10.2 CHGA SYP
27 ovarian large-cell neuroendocrine carcinoma 10.2 CHGA SYP
28 acinar cell cystadenocarcinoma 10.2 CHGA SYP
29 peritoneal serous adenocarcinoma 10.2 CHGA SYP
30 cellular ependymoma 10.2 CHGA SYP
31 primary hepatic neuroendocrine carcinoma 10.2 CHGA SYP
32 pilomyxoid astrocytoma 10.2 NTRK2 SYP
33 carotid body cancer 10.2 ENO2 SYP
34 chordoid meningioma 10.2 CHGA SYP
35 malignant sertoli cell tumor 10.2 ENO2 SYP
36 olfactory groove meningioma 10.2 CHGA SYP
37 sinonasal undifferentiated carcinoma 10.2 ENO2 SYP
38 adult astrocytic tumour 10.2 ATRX BDNF
39 spinal meningioma 10.2 CHGA ENO2
40 pancreatic somatostatinoma 10.2 ENO2 SYP
41 cutaneous ganglioneuroma 10.2 ENO2 SYP
42 pancreatic serous cystadenoma 10.2 CHGA SYP
43 heart sarcoma 10.2 ENO2 MDM2
44 extrahepatic bile duct adenocarcinoma 10.2 ENO2 SYP
45 actinic cheilitis 10.2 CDKN1A MDM2
46 conventional angiosarcoma 10.2 CHGA SYP
47 papillary tumor of the pineal region 10.2 ENO2 SYP
48 sensory organ benign neoplasm 10.2 ENO2 SYP
49 orbital cancer 10.2 ENO2 SYP
50 middle ear adenoma 10.2 ENO2 SYP

Graphical network of the top 20 diseases related to Nodular Ganglioneuroblastoma:



Diseases related to Nodular Ganglioneuroblastoma

Symptoms & Phenotypes for Nodular Ganglioneuroblastoma

MGI Mouse Phenotypes related to Nodular Ganglioneuroblastoma:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.19 ALK ATRX BDNF CDKN1A ENO2 MDM2
2 cellular MP:0005384 10.08 ATRX BDNF CDKN1A ENO2 MDM2 MYCN
3 growth/size/body region MP:0005378 10.06 ALK ATRX BDNF CDKN1A CHGA ENO2
4 nervous system MP:0003631 10.06 ALK ATRX BDNF CDKN1A CHGA ENO2
5 mortality/aging MP:0010768 10.02 ALK ATRX BDNF CDKN1A CHGA MDM2
6 endocrine/exocrine gland MP:0005379 9.98 ALK BDNF CDKN1A CHGA MDM2 NTRK2
7 craniofacial MP:0005382 9.85 BDNF CDKN1A ENO2 MDM2 MYCN
8 reproductive system MP:0005389 9.81 ALK ATRX BDNF CDKN1A CHGA MDM2
9 normal MP:0002873 9.73 BDNF MDM2 MYCN NTRK2 POU5F1 SYP
10 respiratory system MP:0005388 9.43 ALK BDNF CDKN1A ENO2 MYCN NTRK2
11 vision/eye MP:0005391 9.1 ALK ATRX BDNF CDKN1A MYCN NTRK2

Drugs & Therapeutics for Nodular Ganglioneuroblastoma

Search Clinical Trials , NIH Clinical Center for Nodular Ganglioneuroblastoma

Genetic Tests for Nodular Ganglioneuroblastoma

Anatomical Context for Nodular Ganglioneuroblastoma

MalaCards organs/tissues related to Nodular Ganglioneuroblastoma:

42
Brain, Pineal, Bone, Kidney, Spinal Cord, Thyroid, Cerebellum

Publications for Nodular Ganglioneuroblastoma

Articles related to Nodular Ganglioneuroblastoma:

# Title Authors Year
1
The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins. ( 25081755 )
2015
2
Large mediastinal nodular ganglioneuroblastoma in a child from Africa. ( 23080230 )
2012
3
Nodular ganglioneuroblastoma in adults. ( 19680497 )
2009
4
Expression of brain-derived neurotrophic factor and tropomyosin-related kinase-B in a bovine jejunal nodular ganglioneuroblastoma. ( 18487493 )
2008

Variations for Nodular Ganglioneuroblastoma

Expression for Nodular Ganglioneuroblastoma

Search GEO for disease gene expression data for Nodular Ganglioneuroblastoma.

Pathways for Nodular Ganglioneuroblastoma

Pathways related to Nodular Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.81 CDKN1A MDM2 MYCN
2 11.65 CDKN1A MDM2 NTRK2
3 11.65 BDNF NTRK2 POU5F1
4 11.46 ENO2 MYCN NTRK2 SYP
5 10.94 BDNF NTRK2
6
Show member pathways
10.5 CDKN1A MDM2
7 10.1 BDNF NTRK2

GO Terms for Nodular Ganglioneuroblastoma

Biological processes related to Nodular Ganglioneuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.56 MDM2 MYCN NTRK2 POU5F1
2 negative regulation of apoptotic process GO:0043066 9.4 CDKN1A MDM2
3 activation of phospholipase C activity GO:0007202 9.37 BDNF NTRK2
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.33 ALK BDNF NTRK2
5 neurotrophin TRK receptor signaling pathway GO:0048011 9.32 BDNF NTRK2
6 positive regulation of non-membrane spanning protein tyrosine kinase activity GO:1903997 8.96 BDNF NTRK2
7 brain-derived neurotrophic factor receptor signaling pathway GO:0031547 8.62 BDNF NTRK2

Sources for Nodular Ganglioneuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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