MCID: NDL007
MIFTS: 47

Nodular Goiter

Categories: Endocrine diseases

Aliases & Classifications for Nodular Goiter

MalaCards integrated aliases for Nodular Goiter:

Name: Nodular Goiter 12 15 17 74
Goiter, Nodular 12 45
Non-Toxic Nodular Goiter 74
Nodular Goitre 12
Goiter Nodular 56

Classifications:



External Ids:

Disease Ontology 12 DOID:13197
MeSH 45 D006044
NCIt 51 C131437

Summaries for Nodular Goiter

MalaCards based summary : Nodular Goiter, also known as goiter, nodular, is related to plummer's disease and hyperthyroidism. An important gene associated with Nodular Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Pathways in cancer and Aldosterone synthesis and secretion. The drugs Remifentanil and Iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and ovary, and related phenotypes are cellular and growth/size/body region

Wikipedia : 77 Nontoxic nodular goiter is an enlarged thyroid without hyperthyroidism. It is often present for years... more...

Related Diseases for Nodular Goiter

Diseases related to Nodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 plummer's disease 32.9 ICAM1 TG TPO
2 hyperthyroidism 30.9 TG TPO TSHR
3 goiter 30.7 CALCA LGALS3 SLC5A5 TG TPO TSHR
4 graves disease 1 30.5 TG TPO TSHR
5 graves' disease 30.4 ICAM1 TG TPO TSHR
6 postsurgical hypothyroidism 30.2 TG TSHR
7 thyroid carcinoma, familial medullary 30.0 CALCA RET TG
8 toxic diffuse goiter 29.9 TG TPO TSHR
9 thyroiditis 29.6 CALCA RET TG TPO TSHR
10 thyroid cancer 29.5 CALCA LGALS3 RET SLC5A5 TG TPO
11 nontoxic goiter 29.4 CALCA TG TPO TSHR
12 multinodular goiter 29.4 CALCA TG TPO TSHR
13 differentiated thyroid carcinoma 29.3 BCL2 RET TG TPO TSHR
14 hypothyroidism 29.2 CALCA RET SLC5A5 TG TPO TSHR
15 papillary carcinoma 28.7 CALCA LGALS3 RET TG TPO TSHR
16 follicular adenoma 28.6 CALCA LGALS3 RET TG TPO TSHR
17 hashimoto thyroiditis 28.4 CALCA FAS ICAM1 LGALS3 RET TG
18 thyroid cancer, nonmedullary, 1 10.4
19 kashin-beck disease 10.4 BCL2 FAS
20 autoimmune lymphoproliferative syndrome, type v 10.3 BCL2 FAS
21 subacute lymphocytic thyroiditis 10.3 TG TPO
22 adenoma 10.3
23 cartilage-hair hypoplasia 10.3 BCL2 FAS
24 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.3 TG TPO
25 human herpesvirus 8 10.3 BCL2 IL6
26 colloid adenoma 10.3 LGALS3 TG
27 premature menopause 10.3 TG TPO
28 pernicious anemia 10.3 TG TPO
29 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.3 TG TPO
30 athyreosis 10.2 TG TSHR
31 cowpox 10.2 FAS IL6
32 hashimoto encephalopathy 10.2 TPO TSHR
33 ovarian germ cell teratoma 10.2 RET TG
34 ovarian germ cell cancer 10.2 RET TG
35 acute thyroiditis 10.2 CALCA TG
36 hyperparathyroidism 10.2
37 mucoepidermoid thyroid carcinoma 10.2 CALCA TG
38 burn scar 10.2 CALCA FAS
39 suppurative thyroiditis 10.2 CALCA TG
40 hyperthyroxinemia 10.2 TPO TSHR
41 thyroid sarcoma 10.2 CALCA TG
42 familial thyroid dyshormonogenesis 10.2 SLC5A5 TG TPO
43 atypical follicular adenoma 10.2 CALCA TG
44 hypothyroidism, congenital, nongoitrous, 4 10.1 TG TPO
45 hypoadrenalism 10.1 CALCA TG
46 bullous impetigo 10.1 CALCA IL6
47 amyloid tumor 10.1 CALCA TG
48 impetigo 10.1 CALCA IL6
49 diabetic foot ulcers 10.1 CALCA IL6
50 primary hyperparathyroidism 10.1

Comorbidity relations with Nodular Goiter via Phenotypic Disease Network (PDN):


Goiter Hypertension, Essential
Hypothyroidism

Graphical network of the top 20 diseases related to Nodular Goiter:



Diseases related to Nodular Goiter

Symptoms & Phenotypes for Nodular Goiter

MGI Mouse Phenotypes related to Nodular Goiter:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 BCL2 FAS ICAM1 IL6 LGALS3 RET
2 growth/size/body region MP:0005378 10.18 BCL2 FAS ICAM1 IL6 LGALS3 RET
3 homeostasis/metabolism MP:0005376 10.17 BCL2 FAS ICAM1 IL6 LGALS3 RET
4 hematopoietic system MP:0005397 10.16 BCL2 FAS ICAM1 IL6 LGALS3 RET
5 endocrine/exocrine gland MP:0005379 10.15 BCL2 FAS ICAM1 IL6 RET SLC5A5
6 digestive/alimentary MP:0005381 10.11 BCL2 FAS ICAM1 IL6 LGALS3 RET
7 immune system MP:0005387 10.1 BCL2 FAS ICAM1 IL6 LGALS3 RET
8 adipose tissue MP:0005375 9.93 BCL2 IL6 LGALS3 TG TNFRSF4
9 mortality/aging MP:0010768 9.91 BCL2 FAS ICAM1 IL6 LGALS3 RET
10 integument MP:0010771 9.85 BCL2 FAS ICAM1 IL6 LGALS3 TNFRSF4
11 limbs/digits/tail MP:0005371 9.72 FAS RET TG TPO TSHR
12 neoplasm MP:0002006 9.7 BCL2 FAS ICAM1 IL6 LGALS3 RET
13 nervous system MP:0003631 9.56 BCL2 FAS ICAM1 IL6 LGALS3 RET
14 vision/eye MP:0005391 9.1 BCL2 FAS ICAM1 IL6 TPO TSHR

Drugs & Therapeutics for Nodular Goiter

Drugs for Nodular Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4 132875-61-7 60815
2
Iodine Approved, Investigational Phase 4 7553-56-2 807
3
Methimazole Approved Phase 4 60-56-0 1349907
4 Peripheral Nervous System Agents Phase 4,Not Applicable
5 Analgesics Phase 4
6 Analgesics, Opioid Phase 4
7 Central Nervous System Depressants Phase 4,Not Applicable
8 Narcotics Phase 4
9 Nutrients Phase 4
10 Anti-Infective Agents Phase 4
11 Anti-Infective Agents, Local Phase 4
12 Trace Elements Phase 4
13 cadexomer iodine Phase 4
14 Micronutrients Phase 4
15 Hormone Antagonists Phase 4
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
17 Hormones Phase 4
18 Antithyroid Agents Phase 4
19
Bupivacaine Approved, Investigational Not Applicable 38396-39-3, 2180-92-9 2474
20
Dactinomycin Approved, Investigational 50-76-0 457193 2019
21
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
22
Ifosfamide Approved 3778-73-2 3690
23
Doxorubicin Approved, Investigational 23214-92-8 31703
24
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
25
Silver sulfadiazine Approved, Vet_approved 22199-08-2 441244
26
Doxil Approved June 1999 31703
27 Anesthetics Not Applicable
28 Anesthetics, Local Not Applicable
29
Isophosphamide mustard 0

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
2 LISA-study : Levothyroxin in Nodular Goiter Completed NCT00277589 Phase 4 Levothyroxin-Na;Levothyroxine-Na + iodide;Iodide;Placebo
3 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
4 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
5 Laser Therapy of Benign Thyroid Nodules Unknown status NCT00150150 Phase 3
6 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
7 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
8 Changes in Esophageal Motility and Swallowing Symptoms After Thyroid Surgery Unknown status NCT03100357
9 Cognitive Functions During Thyrotropin Suppressive Therapy in Patients With Differentiated Thyroid Carcinoma Unknown status NCT02665325 TSH-suppressive therapy
10 Levothyroxine Treatment in Thyroid Benign Nodular Goiter Completed NCT00552253 Not Applicable Levothyroxin treatment
11 Elastography in Thyroid Nodules Completed NCT01102127
12 Tracheal Anatomy After Thyroidectomy Completed NCT03072654
13 Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively Completed NCT00941551 levothyroxine;no levothyroxine
14 Pilot Study on Laser Ablation of Symptomatic Benign Thyroid Masses Completed NCT00615537 Not Applicable
15 Late Postoperative Course of Patients With Mini Video Assisted Thyroidectomy (miVAT) Versus Classic Thyroidectomy (T) Completed NCT00693147 Not Applicable
16 Immediate Postoperative Course of Patients With Mini Video Assisted Total Thyroidectomy (miVAT) Versus Classic Total Thyroidectomy (cTT) Completed NCT00692835 Not Applicable
17 Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter Completed NCT00946894 Not Applicable
18 Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter Completed NCT01588288 Not Applicable
19 Study of the Efficacy of Local Analgesia as an Adjunct to General Anesthesia in Thyroidectomy and Parathyroidectomy Completed NCT02205801 Not Applicable 0.9% saline;Marcaine
20 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
21 Long Period Observation of Biochemical Survey and Ultrasonography in Thyroid Diseases and Subclinical Thyroid Diseases Active, not recruiting NCT02868476
22 Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism Active, not recruiting NCT02005250
23 Clinical Prediction Thyroid Cancer With Thyroid Ultrasonography Enrolling by invitation NCT03294005
24 Application of Ultrasonic Gray-scale Ratio in Differentiating Benign From Malignant Thyroid Nodules. Not yet recruiting NCT03700762

Search NIH Clinical Center for Nodular Goiter

Cochrane evidence based reviews: goiter, nodular

Genetic Tests for Nodular Goiter

Anatomical Context for Nodular Goiter

MalaCards organs/tissues related to Nodular Goiter:

42
Thyroid, Bone, Ovary, B Cells, T Cells, Endothelial, Kidney

Publications for Nodular Goiter

Articles related to Nodular Goiter:

(show top 50) (show all 305)
# Title Authors Year
1
Diagnostic pitfalls in a cystic ectopic intrathyroidal parathyroid adenoma mimicking a nodular goiter: A care-compliant case report. ( 30702624 )
2019
2
Metformin reduces risk of benign nodular goiter in patients with type 2 diabetes mellitus. ( 30986765 )
2019
3
A lute player peasant with nodular goiter by Bartolomeo Passarotti (1529-1592). ( 30628045 )
2019
4
Toxic nodular goiter and thyroid cancer: Is hyperthyroidism protective against thyroid cancer? ( 31104806 )
2019
5
Hashimoto's thyroiditis, nodular goiter or follicular adenoma combined with papillary thyroid carcinoma play protective role in patients. ( 29788738 )
2018
6
The impact of surgery on quality of life, esophageal motility, and tracheal anatomy and airflow in patients with benign nodular goiter. ( 29619937 )
2018
7
Calcitonin Screening in Nodular Goiter-Upper Limits. ( 29669679 )
2018
8
Systemic Retinoids and Thyrotoxicosis in (Multi) Nodular Goiter: Side Effect or Coincidence? ( 29937568 )
2018
9
An assessment of the relationship between thyroid nodule characteristics, insulin resistance and arterial stiffness in euthyroid nodular goiter. ( 30084100 )
2018
10
The effect of suppressive thyroxine therapy in nodular goiter in postmenopausal women and 2 year's bone mineral density change. ( 30158361 )
2018
11
Outcome of radioactive iodine therapy in Toxic Nodular Goiter in Pakistan. ( 30344566 )
2018
12
Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma. ( 28891673 )
2017
13
A rare case of poorly differentiated thyroid carcinoma probably arising from a nodular goiter. ( 28588422 )
2017
14
Association between single nucleotide variants of vascular endothelial growth factor A and the risk of thyroid carcinoma and nodular goiter in a Han Chinese population. ( 28178662 )
2017
15
Low Iodine in the Follicular Lumen Caused by Cytoplasm Mis-localization of Sodium Iodide Symporter may Induce Nodular Goiter. ( 28190186 )
2017
16
Frequency of nodular goiter and autoimmune thyroid disease and association of these disorders with insulin resistance in polycystic ovary syndrome. ( 28400351 )
2017
17
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter. ( 28471268 )
2017
18
Higher urinary bisphenol A concentration and excessive iodine intake are associated with nodular goiter and papillary thyroid carcinoma. ( 28684549 )
2017
19
A case of intravascular large B cell lymphoma presenting as nodular goiter. ( 28841887 )
2017
20
Quality of life after thyroidectomy in patients with nontoxic nodular goiter: A prospective cohort study. ( 28872214 )
2017
21
Thyroidectomy Improves Tracheal Anatomy and Airflow in Patients with Nodular Goiter: A Prospective Cohort Study. ( 29234624 )
2017
22
An evaluation of the diagnostic efficacy of fine needle aspiration biopsy in patients operated for a thyroid nodular goiter. ( 27703381 )
2016
23
Risk of Malignancy in Symptomatic Nodular Goiter Treated with Radiofrequency Ablation. ( 26585266 )
2016
24
Expression patterns of cytokeratin 5/6 and p63 in thyroid sporadic nodular goiter. ( 26878564 )
2016
25
A Rare Case of a Postoperative Submandibular Exophytic Goiter in a Patient With a Recurrent Normotopic Nodular Goiter. ( 27055140 )
2016
26
Lack of Variation in Inflammatory Hematological Parameters between Benign Nodular Goiter and Papillary Thyroid Cancer. ( 27221938 )
2016
27
Iodinated Contrast Media-Induced Thyroid Dysfunction in Euthyroid Nodular Goiter Patients. ( 27315873 )
2016
28
Quality-of-Life Impairments Persist Six Months After Treatment of Graves' Hyperthyroidism and Toxic Nodular Goiter: A Prospective Cohort Study. ( 27370744 )
2016
29
Upregulation of TSHR, TTF-1, and PAX8 in Nodular Goiter Is Associated with Iodine Deficiency in the Follicular Lumen. ( 27525008 )
2016
30
Effectiveness of Radioiodine Treatment for Toxic Nodular Goiter. ( 27529884 )
2015
31
Graves Disease Induced by Radioiodine Therapy for Toxic Nodular Goiter: A Case Report. ( 27529890 )
2015
32
Ghrelin and obestatin in thyroid gland - immunohistochemical expression in nodular goiter, papillary and medullary cancer. ( 25765090 )
2015
33
The prevalence of benign breast diseases in patients with nodular goiter and Hashimoto's thyroiditis. ( 25827711 )
2015
34
Thiamazole Pretreatment Lowers the (131)I Activity Needed to Cure Hyperthyroidism in Patients With Nodular Goiter. ( 25867812 )
2015
35
Thyroid cancer in patients with toxic nodular goiter--is the incidence increasing? ( 25896315 )
2015
36
Systemic oxidative stress to nucleic acids is unaltered following radioiodine therapy of patients with benign nodular goiter. ( 25960958 )
2015
37
Total versus bilateral subtotal thyroidectomy for benign multi-nodular goiter. ( 26064391 )
2015
38
Different Expression of Erythrocyte Sedimentation Rate and C-reactive Protein in Papillary Thyroid Carcinoma and Nodular Goiter. ( 26299079 )
2015
39
Acute airway obstruction due to benign asymptomatic nodular goiter in the cervical region: A case report. ( 26622689 )
2015
40
Long-Term Results of Fixed High-Dose I-131 Treatment for Toxic Nodular Goiter: Higher Euthyroidism Rates in Geriatric Patients. ( 27529883 )
2015
41
Prevalence of simple nodular goiter and Hashimoto's thyroiditis in current, previous, and never smokers in a geographical area with mild iodine deficiency. ( 25153684 )
2015
42
Bone mineral density in geriatric patients with toxic nodular goiter. ( 25161096 )
2015
43
Frequency of nodular goiter and autoimmune thyroid disease in patients with polycystic ovary syndrome. ( 25522724 )
2015
44
Primary thyroid lymphoma has different sonographic and color Doppler features compared to nodular goiter. ( 25614405 )
2015
45
Nodular goiter: cautious indications for surgery. ( 24666652 )
2014
46
The surgical treatment of bilateral benign nodular goiter: balancing invasiveness with complications. ( 24666653 )
2014
47
Laser ablation and 131-iodine: a 24-month pilot study of combined treatment for large toxic nodular goiter. ( 24684455 )
2014
48
Efficacy of different protocols of radioiodine therapy for treatment of toxic nodular goiter: systematic review and meta-analysis of the literature. ( 24803943 )
2014
49
Nodular goiter with thyroid antibodies in chronic idiopathic urticaria. ( 24852782 )
2014
50
New insights into the diagnosis of nodular goiter. ( 24987460 )
2014

Variations for Nodular Goiter

Expression for Nodular Goiter

Search GEO for disease gene expression data for Nodular Goiter.

Pathways for Nodular Goiter

GO Terms for Nodular Goiter

Cellular components related to Nodular Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.1 FAS ICAM1 LGALS3 TNFRSF4 TPO TSHR
2 immunological synapse GO:0001772 8.96 ICAM1 LGALS3

Biological processes related to Nodular Goiter according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.72 BCL2 FAS IL6
2 positive regulation of multicellular organism growth GO:0040018 9.57 BCL2 TSHR
3 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.56 FAS ICAM1
4 activation of adenylate cyclase activity GO:0007190 9.54 CALCA TSHR
5 cell aging GO:0007569 9.52 BCL2 ICAM1
6 leukocyte cell-cell adhesion GO:0007159 9.51 CALCA ICAM1
7 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.46 FAS LGALS3
8 negative regulation of bone resorption GO:0045779 9.43 CALCA IL6
9 hormone biosynthetic process GO:0042446 9.4 TG TPO
10 positive regulation of immunoglobulin secretion GO:0051024 9.37 IL6 TNFRSF4
11 thyroid hormone generation GO:0006590 9.32 SLC5A5 TPO
12 negative regulation of calcium ion transport into cytosol GO:0010523 9.26 BCL2 CALCA
13 negative regulation of ossification GO:0030279 9.19 BCL2
14 response to pain GO:0048265 9.18 RET
15 positive regulation of neuron maturation GO:0014042 9.16 BCL2 RET
16 iodide transport GO:0015705 8.96 SLC5A5 TG
17 monocyte chemotaxis GO:0002548 8.8 CALCA IL6 LGALS3

Molecular functions related to Nodular Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 8.92 FAS ICAM1 RET TSHR

Sources for Nodular Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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