MCID: NDL007
MIFTS: 46

Nodular Goiter

Categories: Endocrine diseases

Aliases & Classifications for Nodular Goiter

MalaCards integrated aliases for Nodular Goiter:

Name: Nodular Goiter 12 29 15 73
Goiter, Nodular 12 44
Non-Toxic Nodular Goiter 73
Nodular Goitre 12
Goiter Nodular 55

Classifications:



External Ids:

Disease Ontology 12 DOID:13197
MeSH 44 D006044
NCIt 50 C131437

Summaries for Nodular Goiter

MalaCards based summary : Nodular Goiter, also known as goiter, nodular, is related to plummer's disease and goiter. An important gene associated with Nodular Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Pathways in cancer and Aldosterone synthesis and secretion. The drugs Remifentanil and Iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and ovary, and related phenotypes are cellular and growth/size/body region

Related Diseases for Nodular Goiter

Diseases related to Nodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 plummer's disease 33.2 ICAM1 TG TPO
2 goiter 31.0 CALCA LGALS3 SLC5A5 TG TPO TSHR
3 hyperthyroidism 30.8 TG TPO TSHR
4 graves' disease 30.4 FAS ICAM1 TG TPO TSHR
5 thyroid carcinoma, familial medullary 30.1 CALCA RET TG
6 thyroiditis 29.9 CALCA RET TG TPO TSHR
7 toxic diffuse goiter 29.9 TG TPO TSHR
8 thyroid cancer 29.7 CALCA LGALS3 RET SLC5A5 TG TPO
9 nontoxic goiter 29.6 CALCA TG TPO TSHR
10 multinodular goiter 29.6 CALCA TG TPO TSHR
11 hypothyroidism 29.5 CALCA RET SLC5A5 TG TPO TSHR
12 differentiated thyroid carcinoma 29.5 BCL2 RET TG TPO TSHR
13 papillary carcinoma 29.1 CALCA LGALS3 RET TG TPO TSHR
14 follicular adenoma 29.0 CALCA LGALS3 RET TG TPO TSHR
15 hashimoto thyroiditis 28.6 CALCA FAS ICAM1 LGALS3 RET TG
16 thyroid cancer, nonmedullary, 1 10.3
17 adenoma 10.3
18 chronic venous leg ulcers 10.2 BCL2 FAS
19 kashin-beck disease 10.2 BCL2 FAS
20 autoimmune lymphoproliferative syndrome, type v 10.2 BCL2 FAS
21 extramedullary plasmacytoma 10.2 BCL2 IL6
22 subacute lymphocytic thyroiditis 10.2 TG TPO
23 cartilage-hair hypoplasia 10.2 BCL2 FAS
24 human herpesvirus 8 10.2 BCL2 IL6
25 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.2 TG TPO
26 hyperparathyroidism 10.2
27 colloid adenoma 10.2 LGALS3 TG
28 premature menopause 10.2 TG TPO
29 pernicious anemia 10.2 TG TPO
30 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.2 TG TPO
31 athyreosis 10.2 TG TSHR
32 postsurgical hypothyroidism 10.2 TG TSHR
33 hashimoto encephalopathy 10.1 TPO TSHR
34 ovarian germ cell teratoma 10.1 RET TG
35 cowpox 10.1 FAS IL6
36 ovarian germ cell cancer 10.1 RET TG
37 acute thyroiditis 10.1 CALCA TG
38 primary hyperparathyroidism 10.1
39 mucoepidermoid thyroid carcinoma 10.1 CALCA TG
40 suppurative thyroiditis 10.1 CALCA TG
41 burn scar 10.1 CALCA FAS
42 thyroid sarcoma 10.1 CALCA TG
43 hyperthyroxinemia 10.1 TPO TSHR
44 familial thyroid dyshormonogenesis 10.1 SLC5A5 TG TPO
45 atypical follicular adenoma 10.1 CALCA TG
46 bullous impetigo 10.1 CALCA IL6
47 impetigo 10.1 CALCA IL6
48 hypoadrenalism 10.1 CALCA TG
49 amyloid tumor 10.1 CALCA TG
50 diabetic foot ulcers 10.1 CALCA IL6

Comorbidity relations with Nodular Goiter via Phenotypic Disease Network (PDN):


Goiter Hypertension, Essential
Hypothyroidism

Graphical network of the top 20 diseases related to Nodular Goiter:



Diseases related to Nodular Goiter

Symptoms & Phenotypes for Nodular Goiter

MGI Mouse Phenotypes related to Nodular Goiter:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 BCL2 FAS ICAM1 IL6 LGALS3 RET
2 growth/size/body region MP:0005378 10.18 BCL2 FAS ICAM1 IL6 LGALS3 RET
3 homeostasis/metabolism MP:0005376 10.17 BCL2 FAS ICAM1 IL6 LGALS3 RET
4 hematopoietic system MP:0005397 10.16 BCL2 FAS ICAM1 IL6 LGALS3 RET
5 endocrine/exocrine gland MP:0005379 10.15 BCL2 FAS ICAM1 IL6 RET SLC5A5
6 digestive/alimentary MP:0005381 10.11 BCL2 FAS ICAM1 IL6 LGALS3 RET
7 immune system MP:0005387 10.1 BCL2 FAS ICAM1 IL6 LGALS3 RET
8 adipose tissue MP:0005375 9.93 BCL2 IL6 LGALS3 TG TNFRSF4
9 mortality/aging MP:0010768 9.91 BCL2 FAS ICAM1 IL6 LGALS3 RET
10 integument MP:0010771 9.85 BCL2 FAS ICAM1 IL6 LGALS3 TNFRSF4
11 limbs/digits/tail MP:0005371 9.72 FAS RET TG TPO TSHR
12 neoplasm MP:0002006 9.7 BCL2 FAS ICAM1 IL6 LGALS3 RET
13 nervous system MP:0003631 9.56 BCL2 FAS ICAM1 IL6 LGALS3 RET
14 vision/eye MP:0005391 9.1 BCL2 FAS ICAM1 IL6 TPO TSHR

Drugs & Therapeutics for Nodular Goiter

Drugs for Nodular Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4 132875-61-7 60815
2
Iodine Approved, Investigational Phase 4 7553-56-2 807
3
Methimazole Approved Phase 4 60-56-0 1349907
4 Analgesics Phase 4
5 Anesthetics, Intravenous Phase 4
6 Central Nervous System Depressants Phase 4
7 Peripheral Nervous System Agents Phase 4
8 Narcotics Phase 4
9 Anesthetics Phase 4,Not Applicable
10 Analgesics, Opioid Phase 4
11 Hypnotics and Sedatives Phase 4
12 Anesthetics, General Phase 4
13 Micronutrients Phase 4
14 Trace Elements Phase 4
15 cadexomer iodine Phase 4
16 Anti-Infective Agents Phase 4
17 Anti-Infective Agents, Local Phase 4
18 Antithyroid Agents Phase 4
19 Hormones Phase 4
20 Hormone Antagonists Phase 4
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
22
Dactinomycin Approved, Investigational 50-76-0 457193 2019
23
Cyclophosphamide Approved, Investigational 6055-19-2, 50-18-0 2907
24
Vincristine Approved, Investigational 57-22-7, 2068-78-2 5978
25
Ifosfamide Approved 3778-73-2 3690
26
Doxorubicin Approved, Investigational 23214-92-8 31703
27
Silver sulfadiazine Approved, Vet_approved 22199-08-2 441244
28
Doxil Approved June 1999 31703
29
Isophosphamide mustard 0

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
2 LISA-study : Levothyroxin in Nodular Goiter Completed NCT00277589 Phase 4 Levothyroxin-Na;Levothyroxine-Na + iodide;Iodide;Placebo
3 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
4 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
5 Laser Therapy of Benign Thyroid Nodules Unknown status NCT00150150 Phase 3
6 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
7 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
8 Cognitive Functions During Thyrotropin Suppressive Therapy in Patients With Differentiated Thyroid Carcinoma Unknown status NCT02665325 TSH-suppressive therapy
9 Levothyroxine Treatment in Thyroid Benign Nodular Goiter Completed NCT00552253 Not Applicable Levothyroxin treatment
10 Elastography in Thyroid Nodules Completed NCT01102127
11 Tracheal Anatomy After Thyroidectomy Completed NCT03072654
12 Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively Completed NCT00941551 levothyroxine;no levothyroxine
13 Pilot Study on Laser Ablation of Symptomatic Benign Thyroid Masses Completed NCT00615537 Not Applicable
14 Late Postoperative Course of Patients With Mini Video Assisted Thyroidectomy (miVAT) Versus Classic Thyroidectomy (T) Completed NCT00693147 Not Applicable
15 Immediate Postoperative Course of Patients With Mini Video Assisted Total Thyroidectomy (miVAT) Versus Classic Total Thyroidectomy (cTT) Completed NCT00692835 Not Applicable
16 Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter Completed NCT00946894 Not Applicable
17 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
18 Changes in Esophageal Motility and Swallowing Symptoms After Thyroid Surgery Active, not recruiting NCT03100357
19 Long Period Observation of Biochemical Survey and Ultrasonography in Thyroid Diseases and Subclinical Thyroid Diseases Active, not recruiting NCT02868476
20 Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism Active, not recruiting NCT02005250
21 Clinical Prediction Thyroid Cancer With Thyroid Ultrasonography Enrolling by invitation NCT03294005
22 Application of Ultrasonic Gray-scale Ratio in Differentiating Benign From Malignant Thyroid Nodules. Not yet recruiting NCT03700762

Search NIH Clinical Center for Nodular Goiter

Cochrane evidence based reviews: goiter, nodular

Genetic Tests for Nodular Goiter

Genetic tests related to Nodular Goiter:

# Genetic test Affiliating Genes
1 Nodular Goiter 29

Anatomical Context for Nodular Goiter

MalaCards organs/tissues related to Nodular Goiter:

41
Thyroid, Bone, Ovary, B Cells, Kidney, Heart, T Cells

Publications for Nodular Goiter

Articles related to Nodular Goiter:

(show top 50) (show all 302)
# Title Authors Year
1
The impact of surgery on quality of life, esophageal motility, and tracheal anatomy and airflow in patients with benign nodular goiter. ( 29619937 )
2018
2
Calcitonin Screening in Nodular Goiter-Upper Limits. ( 29669679 )
2018
3
Systemic Retinoids and Thyrotoxicosis in (Multi) Nodular Goiter: Side Effect or Coincidence? ( 29937568 )
2018
4
Hashimoto's thyroiditis, nodular goiter or follicular adenoma combined with papillary thyroid carcinoma play protective role in patients. ( 29788738 )
2018
5
An assessment of the relationship between thyroid nodule characteristics, insulin resistance and arterial stiffness in euthyroid nodular goiter. ( 30084100 )
2018
6
The effect of suppressive thyroxine therapy in nodular goiter in postmenopausal women and 2 year's bone mineral density change. ( 30158361 )
2018
7
Outcome of radioactive iodine therapy in Toxic Nodular Goiter in Pakistan. ( 30344566 )
2018
8
Low Iodine in the Follicular Lumen Caused by Cytoplasm Mis-localization of Sodium Iodide Symporter may Induce Nodular Goiter. ( 28190186 )
2017
9
Higher urinary bisphenol A concentration and excessive iodine intake are associated with nodular goiter and papillary thyroid carcinoma. ( 28684549 )
2017
10
Frequency of nodular goiter and autoimmune thyroid disease and association of these disorders with insulin resistance in polycystic ovary syndrome. ( 28400351 )
2017
11
Thyroidectomy Improves Tracheal Anatomy and Airflow in Patients with Nodular Goiter: A Prospective Cohort Study. ( 29234624 )
2017
12
A case of intravascular large B cell lymphoma presenting as nodular goiter. ( 28841887 )
2017
13
Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma. ( 28891673 )
2017
14
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter. ( 28471268 )
2017
15
A rare case of poorly differentiated thyroid carcinoma probably arising from a nodular goiter. ( 28588422 )
2017
16
Quality of life after thyroidectomy in patients with nontoxic nodular goiter: A prospective cohort study. ( 28872214 )
2017
17
Association between single nucleotide variants of vascular endothelial growth factor A and the risk of thyroid carcinoma and nodular goiter in a Han Chinese population. ( 28178662 )
2017
18
Risk of Malignancy in Symptomatic Nodular Goiter Treated with Radiofrequency Ablation. ( 26585266 )
2016
19
Iodinated Contrast Media-Induced Thyroid Dysfunction in Euthyroid Nodular Goiter Patients. ( 27315873 )
2016
20
SHOULD FNA BE PERFORMED IN PATIENTS WITH A MULTI-NODULAR GOITER AND COMPRESSIVE SYMPTOMS? ( 27042747 )
2016
21
An evaluation of the diagnostic efficacy of fine needle aspiration biopsy in patients operated for a thyroid nodular goiter. ( 27703381 )
2016
22
Expression patterns of cytokeratin 5/6 and p63 in thyroid sporadic nodular goiter. ( 26878564 )
2016
23
Lack of Variation in Inflammatory Hematological Parameters between Benign Nodular Goiter and Papillary Thyroid Cancer. ( 27221938 )
2016
24
A Rare Case of a Postoperative Submandibular Exophytic Goiter in a Patient With a Recurrent Normotopic Nodular Goiter. ( 27055140 )
2016
25
Upregulation of TSHR, TTF-1, and PAX8 in Nodular Goiter Is Associated with Iodine Deficiency in the Follicular Lumen. ( 27525008 )
2016
26
Quality-of-Life Impairments Persist Six Months After Treatment of Graves' Hyperthyroidism and Toxic Nodular Goiter: A Prospective Cohort Study. ( 27370744 )
2016
27
Acute airway obstruction due to benign asymptomatic nodular goiter in the cervical region: A case report. ( 26622689 )
2015
28
Long-Term Results of Fixed High-Dose I-131 Treatment for Toxic Nodular Goiter: Higher Euthyroidism Rates in Geriatric Patients. ( 27529883 )
2015
29
Effectiveness of Radioiodine Treatment for Toxic Nodular Goiter. ( 27529884 )
2015
30
Systemic oxidative stress to nucleic acids is unaltered following radioiodine therapy of patients with benign nodular goiter. ( 25960958 )
2015
31
Different Expression of Erythrocyte Sedimentation Rate and C-reactive Protein in Papillary Thyroid Carcinoma and Nodular Goiter. ( 26299079 )
2015
32
Graves Disease Induced by Radioiodine Therapy for Toxic Nodular Goiter: A Case Report. ( 27529890 )
2015
33
Total versus bilateral subtotal thyroidectomy for benign multi-nodular goiter. ( 26064391 )
2015
34
The prevalence of benign breast diseases in patients with nodular goiter and Hashimoto's thyroiditis. ( 25827711 )
2015
35
Ghrelin and obestatin in thyroid gland - immunohistochemical expression in nodular goiter, papillary and medullary cancer. ( 25765090 )
2015
36
Thyroid cancer in patients with toxic nodular goiter-is the incidence increasing? ( 25896315 )
2015
37
Primary thyroid lymphoma has different sonographic and color Doppler features compared to nodular goiter. ( 25614405 )
2015
38
Thiamazole pretreatment lowers the (131)I activity needed to cure hyperthyroidism in patients with nodular goiter. ( 25867812 )
2015
39
Bone mineral density in geriatric patients with toxic nodular goiter. ( 25161096 )
2015
40
Diagnostic role of ultrasound and elastosonography in nodular goiter. ( 25047203 )
2014
41
Thyroid hemiagenesis associated with retrosternal nodular goiter: a case report. ( 25325212 )
2014
42
Nodular goiter with thyroid antibodies in chronic idiopathic urticaria. ( 24852782 )
2014
43
Laser ablation and 131-iodine: a 24-month pilot study of combined treatment for large toxic nodular goiter. ( 24684455 )
2014
44
Recombinant Human Thyrotropin Before Iodine-131 Therapy in Patients with Nodular Goiter: A Meta-analysis of Randomized Controlled Trials. ( 25370124 )
2014
45
Elevated Serum Thyroglobulin and Low Iodine Intake Are Associated with Nontoxic Nodular Goiter among Adults Living near the Eastern Mediterranean Coast. ( 25610705 )
2014
46
Nodular goiter: cautious indications for surgery. ( 24666652 )
2014
47
Frequency of nodular goiter and autoimmune thyroid disease in patients with polycystic ovary syndrome. ( 25522724 )
2014
48
ANIMAL MODELS OF DISEASE: Feline hyperthyroidism: an animal model for toxic nodular goiter. ( 25297557 )
2014
49
Prevalence of Simple Nodular Goiter and Hashimoto's Thyroiditis in Current, Previous, and Never Smokers in a Geographical Area with Mild Iodine Deficiency. ( 25153684 )
2014
50
Disparity expression of gammaH2AX in papillary thyroid cancer and nodular goiter. ( 25651738 )
2014

Variations for Nodular Goiter

Expression for Nodular Goiter

Search GEO for disease gene expression data for Nodular Goiter.

Pathways for Nodular Goiter

GO Terms for Nodular Goiter

Cellular components related to Nodular Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.1 FAS ICAM1 LGALS3 TNFRSF4 TPO TSHR
2 immunological synapse GO:0001772 8.96 ICAM1 LGALS3

Biological processes related to Nodular Goiter according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.85 BCL2 FAS IL6 RET
2 positive regulation of multicellular organism growth GO:0040018 9.57 BCL2 TSHR
3 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.56 FAS ICAM1
4 activation of adenylate cyclase activity GO:0007190 9.54 CALCA TSHR
5 cell aging GO:0007569 9.52 BCL2 ICAM1
6 leukocyte cell-cell adhesion GO:0007159 9.51 CALCA ICAM1
7 negative regulation of ossification GO:0030279 9.49 BCL2 CALCA
8 response to pain GO:0048265 9.48 CALCA RET
9 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.46 FAS LGALS3
10 negative regulation of bone resorption GO:0045779 9.43 CALCA IL6
11 hormone biosynthetic process GO:0042446 9.4 TG TPO
12 positive regulation of immunoglobulin secretion GO:0051024 9.37 IL6 TNFRSF4
13 thyroid hormone generation GO:0006590 9.32 SLC5A5 TPO
14 negative regulation of calcium ion transport into cytosol GO:0010523 9.26 BCL2 CALCA
15 positive regulation of neuron maturation GO:0014042 9.16 BCL2 RET
16 iodide transport GO:0015705 8.96 SLC5A5 TG
17 monocyte chemotaxis GO:0002548 8.8 CALCA IL6 LGALS3

Molecular functions related to Nodular Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 8.92 FAS ICAM1 RET TSHR

Sources for Nodular Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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