MCID: NDL007
MIFTS: 48

Nodular Goiter

Categories: Endocrine diseases

Aliases & Classifications for Nodular Goiter

MalaCards integrated aliases for Nodular Goiter:

Name: Nodular Goiter 12 29 15 73
Goiter, Nodular 12 44
Non-Toxic Nodular Goiter 73
Nodular Goitre 12
Goiter Nodular 55

Classifications:



External Ids:

Disease Ontology 12 DOID:13197
MeSH 44 D006044

Summaries for Nodular Goiter

MalaCards based summary : Nodular Goiter, also known as goiter, nodular, is related to plummer's disease and hyperthyroidism. An important gene associated with Nodular Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Remifentanil and Iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and endothelial, and related phenotypes are cellular and hematopoietic system

Wikipedia : 76 Nodular goiter can refer... more...

Related Diseases for Nodular Goiter

Diseases related to Nodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 plummer's disease 32.5 ICAM1 TG TPO
2 hyperthyroidism 31.0 TG TPO TSHR
3 goiter 30.6 CALCA LGALS3 TG TPO TSHR
4 toxic diffuse goiter 30.1 TG TPO TSHR
5 thyroid carcinoma, familial medullary 30.1 CALCA RET TG
6 thyroiditis 30.1 CALCA RET TG TPO TSHR
7 graves' disease 29.9 ICAM1 TG TPO TSHR
8 nontoxic goiter 29.3 CALCA TG TPO TSHR
9 adenoma 29.3 BRAF RET TSHR
10 multinodular goiter 29.3 CALCA TG TPO TSHR
11 hypothyroidism 29.3 CALCA RET TG TPO TSHR
12 thyroid cancer, nonmedullary, 1 29.2 BRAF LGALS3 RET TG
13 follicular adenoma 28.0 CALCA LGALS3 RET TG TPO TSHR
14 differentiated thyroid carcinoma 28.0 BRAF RET TG TPO TSHR
15 thyroid cancer 27.4 BRAF CALCA LGALS3 RET TG TPO
16 familial thyroid dyshormonogenesis 10.8 TG TPO
17 subacute lymphocytic thyroiditis 10.8 TG TPO
18 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.7 TG TPO
19 premature menopause 10.7 TG TPO
20 hypothyroidism, congenital, nongoitrous, 4 10.7 TG TPO
21 athyreosis 10.7 TG TSHR
22 ovarian germ cell teratoma 10.6 RET TG
23 pernicious anemia 10.6 TG TPO
24 ovarian germ cell cancer 10.6 RET TG
25 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.6 TG TPO
26 mucoepidermoid thyroid carcinoma 10.6 CALCA TG
27 suppurative thyroiditis 10.6 CALCA TG
28 thyroid sarcoma 10.6 CALCA TG
29 atypical follicular adenoma 10.5 CALCA TG
30 bullous impetigo 10.5 CALCA IL6
31 crimean-congo hemorrhagic fever 10.5 CXCL10 IL6
32 acute thyroiditis 10.5 CALCA TG
33 hypoadrenalism 10.5 CALCA TG
34 hyperthyroxinemia 10.5 TPO TSHR
35 impetigo 10.5 CALCA IL6
36 stromal keratitis 10.5 CXCL10 IL6
37 castleman disease 10.4 IL6 IL6R
38 amyloid tumor 10.4 CALCA TG
39 human herpesvirus 8 10.4 IL6 IL6R
40 neonatal hypothyroidism 10.4 TG TPO TSHR
41 immune system disease 10.4 IL6 TG TSHR
42 graves disease 1 10.3 TG TPO TSHR
43 myxedema 10.3 TG TPO TSHR
44 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3 TG TPO TSHR
45 hypothyroidism, congenital, nongoitrous, 2 10.3 LGALS3 TG TSHR
46 preterm premature rupture of the membranes 10.3 IL6 IL6R
47 congenital hypothyroidism 10.3 TG TPO TSHR
48 exophthalmos 10.3 TG TSHR
49 chronic eosinophilic pneumonia 10.3 ICAM1 IL6
50 ovarian cystic teratoma 10.3 CALCA TG

Comorbidity relations with Nodular Goiter via Phenotypic Disease Network (PDN):


Goiter Hypertension, Essential
Hypothyroidism

Graphical network of the top 20 diseases related to Nodular Goiter:



Diseases related to Nodular Goiter

Symptoms & Phenotypes for Nodular Goiter

MGI Mouse Phenotypes related to Nodular Goiter:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.13 TSHR RET TNFRSF4 LGALS3 ICAM1 IL6
2 hematopoietic system MP:0005397 10.11 TG TNFRSF4 TPO TSHR RET IL6
3 growth/size/body region MP:0005378 10.06 TSHR RET TG TNFRSF4 TPO ICAM1
4 homeostasis/metabolism MP:0005376 10.06 TG TNFRSF4 TPO TSHR RET IL6
5 endocrine/exocrine gland MP:0005379 10.03 TSHR RET TG TPO ICAM1 IL6
6 immune system MP:0005387 9.96 TSHR RET TNFRSF4 TPO ICAM1 LGALS3
7 digestive/alimentary MP:0005381 9.93 RET TNFRSF4 LGALS3 ICAM1 IL6 BRAF
8 mortality/aging MP:0010768 9.85 TSHR RET TNFRSF4 TPO LGALS3 ICAM1
9 neoplasm MP:0002006 9.5 TSHR ICAM1 LGALS3 RET IL6 BRAF
10 nervous system MP:0003631 9.28 TSHR RET TG LGALS3 ICAM1 IL6

Drugs & Therapeutics for Nodular Goiter

Drugs for Nodular Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4 132875-61-7 60815
2
Iodine Approved, Investigational Phase 4 7553-56-2 807
3 Analgesics Phase 4
4 Analgesics, Opioid Phase 4
5 Anesthetics Phase 4,Not Applicable
6 Anesthetics, General Phase 4
7 Anesthetics, Intravenous Phase 4
8 Central Nervous System Depressants Phase 4
9 Hypnotics and Sedatives Phase 4
10 Narcotics Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Anti-Infective Agents Phase 4
13 Anti-Infective Agents, Local Phase 4
14 cadexomer iodine Phase 4
15 Micronutrients Phase 4
16 Trace Elements Phase 4
17 Antithyroid Agents Phase 4
18 Hormone Antagonists Phase 4
19 Hormones Phase 4
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
21
Salmon Calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
22
Calcitonin gene-related peptide Investigational Phase 2 83652-28-2
23 Bone Density Conservation Agents Phase 2
24 calcitonin Phase 2
25
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
26
Dactinomycin Approved, Investigational 50-76-0 2019 457193
27
Doxorubicin Approved, Investigational 23214-92-8 31703
28
Ifosfamide Approved 3778-73-2 3690
29
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
30
Silver sulfadiazine Approved, Vet_approved 22199-08-2 441244
31
Doxil Approved June 1999 31703
32
Isophosphamide mustard 0

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
2 LISA-study : Levothyroxin in Nodular Goiter Completed NCT00277589 Phase 4 Levothyroxin-Na;Levothyroxine-Na + iodide;Iodide;Placebo
3 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
4 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
5 Laser Therapy of Benign Thyroid Nodules Unknown status NCT00150150 Phase 3
6 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
7 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
8 Levothyroxine Treatment in Thyroid Benign Nodular Goiter Completed NCT00552253 Not Applicable Levothyroxin treatment
9 Elastography in Thyroid Nodules Completed NCT01102127
10 Tracheal Anatomy After Thyroidectomy Completed NCT03072654
11 Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively Completed NCT00941551 levothyroxine;no levothyroxine
12 Pilot Study on Laser Ablation of Symptomatic Benign Thyroid Masses Completed NCT00615537 Not Applicable
13 Late Postoperative Course of Patients With Mini Video Assisted Thyroidectomy (miVAT) Versus Classic Thyroidectomy (T) Completed NCT00693147 Not Applicable
14 Immediate Postoperative Course of Patients With Mini Video Assisted Total Thyroidectomy (miVAT) Versus Classic Total Thyroidectomy (cTT) Completed NCT00692835 Not Applicable
15 Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter Completed NCT00946894 Not Applicable
16 Cognitive Functions During Thyrotropin Suppressive Therapy in Patients With Differentiated Thyroid Carcinoma Recruiting NCT02665325 TSH-suppressive therapy
17 Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism Recruiting NCT02005250
18 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
19 Changes in Esophageal Motility and Swallowing Symptoms After Thyroid Surgery Active, not recruiting NCT03100357
20 Long Period Observation of Biochemical Survey and Ultrasonography in Thyroid Diseases and Subclinical Thyroid Diseases Active, not recruiting NCT02868476
21 Clinical Prediction Thyroid Cancer With Thyroid Ultrasonography Enrolling by invitation NCT03294005

Search NIH Clinical Center for Nodular Goiter

Cochrane evidence based reviews: goiter, nodular

Genetic Tests for Nodular Goiter

Genetic tests related to Nodular Goiter:

# Genetic test Affiliating Genes
1 Nodular Goiter 29

Anatomical Context for Nodular Goiter

MalaCards organs/tissues related to Nodular Goiter:

41
Thyroid, Bone, Endothelial, Ovary, Testes, B Cells

Publications for Nodular Goiter

Articles related to Nodular Goiter:

(show top 50) (show all 298)
# Title Authors Year
1
The impact of surgery on quality of life, esophageal motility, and tracheal anatomy and airflow in patients with benign nodular goiter. ( 29619937 )
2018
2
Calcitonin Screening in Nodular Goiter-Upper Limits. ( 29669679 )
2018
3
Systemic Retinoids and Thyrotoxicosis in (Multi) Nodular Goiter: Side Effect or Coincidence? ( 29937568 )
2018
4
Hashimoto's thyroiditis, nodular goiter or follicular adenoma combined with papillary thyroid carcinoma play protective role in patients. ( 29788738 )
2018
5
Low Iodine in the Follicular Lumen Caused by Cytoplasm Mis-localization of Sodium Iodide Symporter may Induce Nodular Goiter. ( 28190186 )
2017
6
Higher urinary bisphenol A concentration and excessive iodine intake are associated with nodular goiter and papillary thyroid carcinoma. ( 28684549 )
2017
7
Frequency of nodular goiter and autoimmune thyroid disease and association of these disorders with insulin resistance in polycystic ovary syndrome. ( 28400351 )
2017
8
Thyroidectomy Improves Tracheal Anatomy and Airflow in Patients with Nodular Goiter: A Prospective Cohort Study. ( 29234624 )
2017
9
A case of intravascular large B cell lymphoma presenting as nodular goiter. ( 28841887 )
2017
10
Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma. ( 28891673 )
2017
11
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter. ( 28471268 )
2017
12
A rare case of poorly differentiated thyroid carcinoma probably arising from a nodular goiter. ( 28588422 )
2017
13
Quality of life after thyroidectomy in patients with nontoxic nodular goiter: A prospective cohort study. ( 28872214 )
2017
14
Association between single nucleotide variants of vascular endothelial growth factor A and the risk of thyroid carcinoma and nodular goiter in a Han Chinese population. ( 28178662 )
2017
15
Risk of Malignancy in Symptomatic Nodular Goiter Treated with Radiofrequency Ablation. ( 26585266 )
2016
16
Iodinated Contrast Media-Induced Thyroid Dysfunction in Euthyroid Nodular Goiter Patients. ( 27315873 )
2016
17
SHOULD FNA BE PERFORMED IN PATIENTS WITH A MULTI-NODULAR GOITER AND COMPRESSIVE SYMPTOMS? ( 27042747 )
2016
18
An evaluation of the diagnostic efficacy of fine needle aspiration biopsy in patients operated for a thyroid nodular goiter. ( 27703381 )
2016
19
Expression patterns of cytokeratin 5/6 and p63 in thyroid sporadic nodular goiter. ( 26878564 )
2016
20
Lack of Variation in Inflammatory Hematological Parameters between Benign Nodular Goiter and Papillary Thyroid Cancer. ( 27221938 )
2016
21
A Rare Case of a Postoperative Submandibular Exophytic Goiter in a Patient With a Recurrent Normotopic Nodular Goiter. ( 27055140 )
2016
22
Upregulation of TSHR, TTF-1, and PAX8 in Nodular Goiter Is Associated with Iodine Deficiency in the Follicular Lumen. ( 27525008 )
2016
23
Quality-of-Life Impairments Persist Six Months After Treatment of Graves' Hyperthyroidism and Toxic Nodular Goiter: A Prospective Cohort Study. ( 27370744 )
2016
24
Acute airway obstruction due to benign asymptomatic nodular goiter in the cervical region: A case report. ( 26622689 )
2015
25
Long-Term Results of Fixed High-Dose I-131 Treatment for Toxic Nodular Goiter: Higher Euthyroidism Rates in Geriatric Patients. ( 27529883 )
2015
26
Effectiveness of Radioiodine Treatment for Toxic Nodular Goiter. ( 27529884 )
2015
27
Systemic oxidative stress to nucleic acids is unaltered following radioiodine therapy of patients with benign nodular goiter. ( 25960958 )
2015
28
Different Expression of Erythrocyte Sedimentation Rate and C-reactive Protein in Papillary Thyroid Carcinoma and Nodular Goiter. ( 26299079 )
2015
29
Graves Disease Induced by Radioiodine Therapy for Toxic Nodular Goiter: A Case Report. ( 27529890 )
2015
30
Total versus bilateral subtotal thyroidectomy for benign multi-nodular goiter. ( 26064391 )
2015
31
The prevalence of benign breast diseases in patients with nodular goiter and Hashimoto's thyroiditis. ( 25827711 )
2015
32
Ghrelin and obestatin in thyroid gland - immunohistochemical expression in nodular goiter, papillary and medullary cancer. ( 25765090 )
2015
33
Thyroid cancer in patients with toxic nodular goiter-is the incidence increasing? ( 25896315 )
2015
34
Primary thyroid lymphoma has different sonographic and color Doppler features compared to nodular goiter. ( 25614405 )
2015
35
Thiamazole pretreatment lowers the (131)I activity needed to cure hyperthyroidism in patients with nodular goiter. ( 25867812 )
2015
36
Diagnostic role of ultrasound and elastosonography in nodular goiter. ( 25047203 )
2014
37
Thyroid hemiagenesis associated with retrosternal nodular goiter: a case report. ( 25325212 )
2014
38
Nodular goiter with thyroid antibodies in chronic idiopathic urticaria. ( 24852782 )
2014
39
Laser ablation and 131-iodine: a 24-month pilot study of combined treatment for large toxic nodular goiter. ( 24684455 )
2014
40
Recombinant Human Thyrotropin Before Iodine-131 Therapy in Patients with Nodular Goiter: A Meta-analysis of Randomized Controlled Trials. ( 25370124 )
2014
41
Elevated Serum Thyroglobulin and Low Iodine Intake Are Associated with Nontoxic Nodular Goiter among Adults Living near the Eastern Mediterranean Coast. ( 25610705 )
2014
42
Nodular goiter: cautious indications for surgery. ( 24666652 )
2014
43
Frequency of nodular goiter and autoimmune thyroid disease in patients with polycystic ovary syndrome. ( 25522724 )
2014
44
ANIMAL MODELS OF DISEASE: Feline hyperthyroidism: an animal model for toxic nodular goiter. ( 25297557 )
2014
45
Prevalence of Simple Nodular Goiter and Hashimoto's Thyroiditis in Current, Previous, and Never Smokers in a Geographical Area with Mild Iodine Deficiency. ( 25153684 )
2014
46
Disparity expression of gammaH2AX in papillary thyroid cancer and nodular goiter. ( 25651738 )
2014
47
The surgical treatment of bilateral benign nodular goiter: balancing invasiveness with complications. ( 24666653 )
2014
48
Efficacy of different protocols of radioiodine therapy for treatment of toxic nodular goiter: systematic review and meta-analysis of the literature. ( 24803943 )
2014
49
New insights into the diagnosis of nodular goiter. ( 24987460 )
2014
50
Bone mineral density in geriatric patients with toxic nodular goiter. ( 25161096 )
2014

Variations for Nodular Goiter

Expression for Nodular Goiter

Search GEO for disease gene expression data for Nodular Goiter.

Pathways for Nodular Goiter

Pathways related to Nodular Goiter according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 BRAF CXCL10 ICAM1 IL6 IL6R LGALS3
2
Show member pathways
12.81 BRAF CXCL10 ICAM1 IL6 IL6R RET
3 12.55 BRAF IL6 IL6R RET
4
Show member pathways
12.51 ICAM1 IL6 TG TPO TSHR
5 11.9 BRAF IL6 IL6R
6 11.88 IL6 IL6R RET
7 11.71 ICAM1 IL6 IL6R
8 11.67 CXCL10 ICAM1 IL6
9 11.63 BRAF IL6 IL6R
10
Show member pathways
11.55 ICAM1 IL6 IL6R
11 11.34 CXCL10 ICAM1 IL6 LGALS3
12 11.19 CXCL10 ICAM1 IL6
13 11.11 IL6 IL6R TPO
14 11.07 IL6 IL6R
15 9.58 TG TPO TSHR

GO Terms for Nodular Goiter

Cellular components related to Nodular Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.55 ICAM1 IL6R TNFRSF4 TPO TSHR
2 extracellular space GO:0005615 9.5 CALCA CXCL10 ICAM1 IL6 LGALS3 TG
3 immunological synapse GO:0001772 9.26 ICAM1 LGALS3
4 interleukin-6 receptor complex GO:0005896 8.62 IL6 IL6R

Biological processes related to Nodular Goiter according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.89 CXCL10 IL6 IL6R TSHR
2 regulation of signaling receptor activity GO:0010469 9.85 CALCA CXCL10 IL6 TG
3 inflammatory response GO:0006954 9.8 CALCA CXCL10 IL6 TNFRSF4
4 response to lipopolysaccharide GO:0032496 9.77 CXCL10 ICAM1 TNFRSF4
5 positive regulation of MAPK cascade GO:0043410 9.73 IL6 RET TNFRSF4
6 cellular response to lipopolysaccharide GO:0071222 9.69 CXCL10 ICAM1 IL6
7 cytokine-mediated signaling pathway GO:0019221 9.62 CXCL10 ICAM1 IL6 IL6R
8 leukocyte cell-cell adhesion GO:0007159 9.58 CALCA ICAM1
9 thyroid gland development GO:0030878 9.58 BRAF TG
10 endocrine pancreas development GO:0031018 9.57 IL6 IL6R
11 response to pain GO:0048265 9.54 CALCA RET
12 positive regulation of chemokine production GO:0032722 9.52 IL6 IL6R
13 interleukin-6-mediated signaling pathway GO:0070102 9.48 IL6 IL6R
14 negative regulation of bone resorption GO:0045779 9.46 CALCA IL6
15 positive regulation of cAMP metabolic process GO:0030816 9.43 CALCA CXCL10
16 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.43 ICAM1 IL6 IL6R
17 hormone biosynthetic process GO:0042446 9.4 TG TPO
18 positive regulation of immunoglobulin secretion GO:0051024 9.37 IL6 TNFRSF4
19 hepatic immune response GO:0002384 9.16 IL6 IL6R
20 positive regulation of leukocyte chemotaxis GO:0002690 9.13 CXCL10 IL6 IL6R
21 monocyte chemotaxis GO:0002548 8.92 CALCA IL6 IL6R LGALS3

Molecular functions related to Nodular Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.13 ICAM1 RET TSHR
2 interleukin-6 receptor binding GO:0005138 8.62 IL6 IL6R

Sources for Nodular Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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