MCID: NDL007
MIFTS: 47

Nodular Goiter

Categories: Endocrine diseases

Aliases & Classifications for Nodular Goiter

MalaCards integrated aliases for Nodular Goiter:

Name: Nodular Goiter 12 15 17 71
Goiter, Nodular 12 43
Non-Toxic Nodular Goiter 71
Nodular Goitre 12
Goiter Nodular 54

Classifications:



External Ids:

Disease Ontology 12 DOID:13197
MeSH 43 D006044
NCIt 49 C131437
SNOMED-CT 67 419153005
UMLS 71 C0018023 C1318500

Summaries for Nodular Goiter

MalaCards based summary : Nodular Goiter, also known as goiter, nodular, is related to plummer's disease and hyperthyroidism. An important gene associated with Nodular Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Remifentanil and Methimazole have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and lymph node, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 74 Nodular goiter is an enlarged thyroid gland with bumps (nodules) on it. It is associated with both high... more...

Related Diseases for Nodular Goiter

Diseases related to Nodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 381)
# Related Disease Score Top Affiliating Genes
1 plummer's disease 33.1 TSHR TPO TG ICAM1
2 hyperthyroidism 31.8 TSHR TPO TG IL6 CTLA4 CRP
3 adenoma 30.9 TSHR TG RET LGALS3 BRAF
4 graves disease 1 30.9 TSHR TPO TG SLC5A5 CALCA
5 endemic goiter 30.7 TSHR TPO TG CALCA
6 nontoxic goiter 30.7 TSHR TPO TG CALCA
7 suppurative thyroiditis 30.7 TG CRP
8 thyroid gland medullary carcinoma 30.7 TG RET CALCA
9 toxic diffuse goiter 30.7 TSHR TPO TG
10 postsurgical hypothyroidism 30.6 TPO TG RET
11 substernal goiter 30.6 TG CALCA
12 parathyroid adenoma 30.5 VEGFA RET LGALS3 CALCA
13 fetal adenoma 30.5 TG CALCA
14 hyperthyroxinemia 30.4 TSHR TPO TG
15 thyroid lymphoma 30.4 TPO TG CALCA
16 pendred syndrome 30.3 TPO TG SLC5A5
17 thyroid carcinoma, familial medullary 30.3 TG RET CALCA BRAF
18 hypoparathyroidism 30.3 TPO RET CTLA4 CALCA
19 parathyroid carcinoma 30.2 RET LGALS3 CALCA
20 graves' disease 30.2 TSHR TPO TG ICAM1 FAS CTLA4
21 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.1 TSHR TPO TG CTLA4
22 atherosclerosis susceptibility 30.0 VEGFA IL6 ICAM1 CRP
23 vascular dementia 30.0 VEGFA IL6 ICAM1 CRP
24 goiter 29.9 VEGFA TSHR TPO TG SLC5A5 RET
25 thyroid carcinoma 29.9 TSHR TPO TG RET LGALS3 HRAS
26 myxedema 29.7 TSHR TPO TG CTLA4
27 multinodular goiter 29.5 VEGFA TSHR TPO TG RET KRT19
28 neuroendocrine tumor 29.4 VEGFA RET KRT19 HRAS CALCA
29 papillary carcinoma 29.3 TSHR TPO TG RET LGALS3 KRT19
30 thymoma 29.2 VEGFA TG IL6 HRAS CTLA4
31 exanthem 29.2 VEGFA IL6 HRAS CTLA4 CRP
32 thyroid tumor 29.2 TPO TG RET LGALS3 HRAS BRAF
33 breast disease 29.1 VEGFA MIR199A1 KRT19 HGF
34 differentiated thyroid carcinoma 29.1 VEGFA TSHR TPO TG RET HRAS
35 thyroid cancer, nonmedullary, 2 29.1 TSHR TG LGALS3 HRAS CALCA BRAF
36 autoimmune disease 29.0 TSHR TPO TNFRSF4 TG IL6 FAS
37 hypothyroidism 28.9 VEGFA TSHR TPO TG SLC5A5 RET
38 thyroiditis 28.9 TSHR TPO TG RET IL6 HRAS
39 diabetes mellitus 28.8 VEGFA IL6 ICAM1 FAS CTLA4 CRP
40 follicular adenoma 28.6 TSHR TPO TG RET LGALS3 KRT19
41 lung disease 28.4 VEGFA RET MIR199A1 KRT19 IL6 ICAM1
42 diabetes mellitus, noninsulin-dependent 28.1 VEGFA TPO MIR199A1 IL6 ICAM1 HRAS
43 thyroid gland disease 28.1 TSHR TPO TG SLC5A5 RET MIR199A1
44 eye disease 28.0 VEGFA TSHR MIR199A1 LGALS3 IL6 ICAM1
45 thyroid gland cancer 27.9 VEGFA TSHR TPO TG SLC5A5 RET
46 hashimoto thyroiditis 27.6 TSHR TPO TG RET LGALS3 KRT19
47 renal cell carcinoma, nonpapillary 26.8 VEGFA RET MIR199A1 KRT19 ICAM1 HRAS
48 mechanical strabismus 10.6 TPO TG
49 cold agglutinin disease 10.5 IL6 CRP
50 multicentric papillary thyroid carcinoma 10.5 TG RET

Comorbidity relations with Nodular Goiter via Phenotypic Disease Network (PDN):


Goiter Hypertension, Essential
Hypothyroidism

Graphical network of the top 20 diseases related to Nodular Goiter:



Diseases related to Nodular Goiter

Symptoms & Phenotypes for Nodular Goiter

MGI Mouse Phenotypes related to Nodular Goiter:

45 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.41 BRAF FAS HGF HRAS ICAM1 IL6
2 homeostasis/metabolism MP:0005376 10.41 BRAF CRP CTLA4 FAS HRAS ICAM1
3 cellular MP:0005384 10.39 BRAF FAS HGF ICAM1 IL6 KRT19
4 endocrine/exocrine gland MP:0005379 10.39 BRAF CTLA4 FAS HRAS ICAM1 IL6
5 hematopoietic system MP:0005397 10.37 BRAF CTLA4 FAS HGF ICAM1 IL6
6 immune system MP:0005387 10.37 BRAF CRP CTLA4 FAS ICAM1 IL6
7 cardiovascular system MP:0005385 10.36 BRAF CRP CTLA4 FAS HGF HRAS
8 digestive/alimentary MP:0005381 10.34 BRAF CTLA4 FAS HRAS ICAM1 IL6
9 mortality/aging MP:0010768 10.28 BRAF CTLA4 FAS HGF HRAS ICAM1
10 integument MP:0010771 10.26 BRAF CTLA4 FAS HRAS ICAM1 IL6
11 craniofacial MP:0005382 10.11 BRAF FAS HRAS KRT19 TNFRSF9 TPO
12 nervous system MP:0003631 10.1 BRAF FAS HRAS ICAM1 IL6 KRT19
13 liver/biliary system MP:0005370 10.09 BRAF CTLA4 FAS HGF IL6 KRT19
14 neoplasm MP:0002006 10.07 BRAF FAS HRAS ICAM1 IL6 KRT19
15 limbs/digits/tail MP:0005371 10 BRAF FAS RET TG TPO TSHR
16 renal/urinary system MP:0005367 9.86 BRAF FAS HRAS IL6 LGALS3 RET
17 respiratory system MP:0005388 9.85 BRAF CTLA4 FAS HRAS IL6 KRT19
18 skeleton MP:0005390 9.77 BRAF CTLA4 FAS HRAS IL6 KRT19
19 vision/eye MP:0005391 9.28 BRAF FAS ICAM1 IL6 SLC5A5 TNFRSF9

Drugs & Therapeutics for Nodular Goiter

Drugs for Nodular Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4 132875-61-7 60815
2
Methimazole Approved Phase 4 60-56-0 1349907
3 Narcotics Phase 4
4 Analgesics Phase 4
5 Analgesics, Opioid Phase 4
6 Trace Elements Phase 4
7 Anti-Infective Agents Phase 4
8 Nutrients Phase 4
9 Anti-Infective Agents, Local Phase 4
10 Micronutrients Phase 4
11 Hormone Antagonists Phase 4
12 Hormones Phase 4
13 Antithyroid Agents Phase 4
14
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
15
Vincristine Approved, Investigational 57-22-7, 2068-78-2 5978
16
Doxorubicin Approved, Investigational 23214-92-8 31703
17
Dactinomycin Approved, Investigational 50-76-0 457193 2019
18
Ifosfamide Approved 3778-73-2 3690
19
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
20
Silver sulfadiazine Approved, Vet_approved 22199-08-2 441244
21
Iodine Approved, Investigational 7553-56-2 807
22 Anesthetics
23 Anesthetics, Local
24
Isophosphamide mustard 0
25
Liposomal doxorubicin 31703
26 cadexomer iodine

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Comparison of Different Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy: a Prospective, Double-blinded Randomized Control Trial Unknown status NCT01761149 Phase 4 Remifentanil
2 TSH-adapted Therapy in a Large Randomized, Observer-blind, Placebo-controlled, Prospective Treatment Study of Patients With Nodular Goiter Completed NCT00277589 Phase 4 Levothyroxin-Na;Levothyroxine-Na + iodide;Iodide;Placebo
3 The Influence of Continuous Treatment With Antithyroid Drugs on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150137 Phase 4 Methimazole
4 The Influence of Continuous Block-replacement Therapy on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
5 Therapeutic Role of Levothyroxine on the Patients With Atypia of Undetermined Significance (AUS) Goiter Withdrawn NCT02329379 Phase 4 Levothyroxine
6 Ultrasound Guided Interstitial Laser Photocoagulation on Benign Thyroid Nodules Unknown status NCT00150150 Phase 3
7 The Effect of 0.1 mg Recombinant Human Thyrotropin (rhTSH) on Thyroid Radioiodine-uptake and the Degree of Goiter Reduction Following 131I-therapy, in Patients With Benign Non-toxic Nodular Goiter. A Randomized, Double-blind, Placebo-controlled Trial. Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
8 Pretreatment With Recombinant Human Thyrotropin (rhTSH) for the Effect on Thyroid Size and Function, and for the Effect of Radioiodine Treatment in Patients With Nodular Goiter. Prospective, Randomized Double-blinded Trials. Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
9 New Thyroid Fine Needle Biopsy Apparatus Unknown status NCT01512212
10 Changes in Esophageal Motility and Swallowing Symptoms After Thyroid Surgery - a Prospective Cohort Study Unknown status NCT03100357
11 Cases of Goiter in Children Attending Assiut University Children Hospital Unknown status NCT03202160
12 ThyrOp: Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic Goiter - Focus on Weight Gain and Mitochondrial Dysfunction Unknown status NCT01358136
13 Thyroidectomy Improves Tracheal Anatomy and Airflow in Patients With Nodular Goiter: A Prospective Cohort Study Completed NCT03072654
14 Accuracy of Ultrasound Elastastography in Thyroid Nodular Disease. Completed NCT01102127
15 Levothyroxine Treatment in Thyroid Benign Nodular Goiter Completed NCT00552253 Levothyroxin treatment
16 Pilot Study on Laser Ablation of Symptomatic Benign Thyroid Masses Completed NCT00615537
17 A Randomized Control Trial Comparing Bilateral Superficial Cervical Plexus Block and Local Wound Infiltration in Thyroidectomy and Parathyroidectomy Completed NCT02205801 0.9% saline;Marcaine
18 Diagnosis Interest of Galectin 3 Dosage in Nodular and Multinodular Goiter Pretreatment Completed NCT01588288
19 Five-year Follow up of a Randomized Clinical Trial of Unilateral Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively Completed NCT00941551 levothyroxine;no levothyroxine
20 Five-year Follow up of a Randomized Clinical Trial of Total Thyroidectomy Versus Dunhill Operation Versus Bilateral Subtotal Thyroidectomy for Multinodular Non-toxic Goiter. Completed NCT00946894
21 Delta Neutrophil Index and Neutrophil Lymphocyte Ratio in Differentiation of Thyroid Malignancy and Nodular Goiter Completed NCT04425512
22 Late Postoperative Course of Patients With Mini Video Assisted Thyroidectomy (miVAT) Versus Classic Thyroidectomy (T) Completed NCT00693147
23 Immediate Postoperative Course of Patients With Mini Video Assisted Total Thyroidectomy (miVAT) Versus Classic Total Thyroidectomy (cTT) Completed NCT00692835
24 International Pleuropulmonary Blastoma Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
25 Early Detection of Autoimmune Thyroid Heart Disease Via Urinary Exosomal Proteins. Recruiting NCT03984006
26 Clinical Prediction Thyroid Cancer With Thyroid Ultrasonography Active, not recruiting NCT03294005
27 Long Period Observation of Biochemical Survey and Ultrasonography in Thyroid Diseases and Subclinical Thyroid Diseases Active, not recruiting NCT02868476
28 Application of Ultrasonic Gray-scale Ratio in Differentiating Benign From Malignant Thyroid Nodules. Not yet recruiting NCT03700762
29 A Randomized, Open-label, Parallel-group Study to Determine the Efficacy of Sequential High-intensity Focused Ultrasound (HIFU) Ablation Versus Fixed-dose Radioiodine-131 Therapy in Moderate-sized Non-toxic Multinodular Goiter Not yet recruiting NCT04009863

Search NIH Clinical Center for Nodular Goiter

Cochrane evidence based reviews: goiter, nodular

Genetic Tests for Nodular Goiter

Anatomical Context for Nodular Goiter

MalaCards organs/tissues related to Nodular Goiter:

40
Thyroid, Testes, Lymph Node, Bone, Neutrophil, Heart, Breast

Publications for Nodular Goiter

Articles related to Nodular Goiter:

(show top 50) (show all 1719)
# Title Authors PMID Year
1
[Transcription and promoter hypermethylation of thyroid stimulating hormone receptor gene in human papillary thyroid carcinoma]. 61 54
20117998 2010
2
Congenital hypothyroidism and late-onset goiter: identification and characterization of a novel mutation in the sodium/iodide symporter of the proband and family members. 61 54
19916865 2009
3
[Expressions of RASSF1A, Galectin-3 and TPO mRNA in papillary thyroid carcinoma and their clinical significance]. 54 61
19799084 2009
4
H-RAS gene expression in human multinodular goiter. 61 54
17290351 2007
5
Isthmus-preserving total bilobectomy: an adequate operation for C-cell hyperplasia. 54 61
16680601 2006
6
Analysis of costimulatory molecules OX40/4-1BB (CD134/CD137) detection on chosen mononuclear cells in children and adolescents with Graves' disease during methimazole therapy. 61 54
16459462 2005
7
[Expression and significance of VEGF, VEGF-C, and VEGF-D in papillary thyroid carcinoma]. 61 54
16159441 2005
8
[Relationship between OX40/4-1 BB (CD134/CD137) costimulatory molecules expression on T lymphocytes and stimulating and blocking autoantibodies to the TSH-receptor in children with Graves' disease]. 61 54
16232366 2005
9
Relationship between CTLA-4 and CD28 molecule expression on T lymphocytes and stimulating and blocking autoantibodies to the TSH-receptor in children with Graves' disease. 61 54
16220002 2005
10
Increased thymidine kinase activity in human thyroid toxic adenomas: effects of exposure to epidermal growth factor in vitro. 61 54
15098918 2004
11
Medullary thyroid carcinoma. 61 54
15658665 2004
12
Calcitonin measurement to detect medullary thyroid carcinoma in nodular goiter: German evidence-based consensus recommendation. 61 54
14758572 2004
13
[Analysis of costimulatory molecules (CD28-CTLA-4/B7) expression on chosen mononuclear cells in adolescents with Graves' disease during methimazole therapy]. 61 54
15504312 2004
14
[Expression of cytokeratins and ret in thyroid papillary carcinoma]. 61 54
14761598 2003
15
[Correlation between serum thyroglobulin and thyroid stimulating hormone in populations with non-toxic goiter]. 54 61
12899791 2003
16
Expression of very late antigen-4 and lymphocyte function-associated antigen-1 on peripheral blood lymphocytes from patients with graves disease. 61 54
12357047 2002
17
[Expression of TTF-1 in thyroid tumors originating from follicular epithelium and its correlation with expression of RET, galectin-3 and mucin-1 genes]. 54 61
11953175 2002
18
Serum levels of cytokines in children and adolescents with Graves' disease and non-toxic nodular goiter. 54 61
11453524 2001
19
[Impact of serum thyroglobulin concentration in the diagnosis of benign and malignant thyroid diseases]. 61 54
10984889 2000
20
Serum levels of the cytokines IL-1beta, IL-6 and ICAM-1 after 131I-treatment of Graves' disease and nodular goiter. 54 61
10965935 2000
21
Concordance of eight kits for antithyroid peroxidase autoantibodies determination. 61 54
10987206 2000
22
Evaluation of routine basal serum calcitonin measurement for early diagnosis of medullary thyroid carcinoma in seven hundred seventy-three patients with nodular goiter. 54 61
10411120 1999
23
Role of serum thyroglobulin in the pre-operative evaluation of follicular thyroid tumours. 54 61
9870733 1998
24
Post-thyroidectomy hypocalcemia: the role of calcitonin, parathormone and serum albumin. 61 54
9239811 1996
25
Differential expression of galectin-1 and galectin-3 in thyroid tumors. Potential diagnostic implications. 54 61
7677193 1995
26
Activation of T lymphocyte subsets by synthetic TSH receptor peptides and recombinant glutamate decarboxylase in autoimmune thyroid disease and insulin-dependent diabetes. 61 54
7714099 1995
27
T-cells recognize multiple epitopes in the human thyrotropin receptor extracellular domain. 54 61
7533773 1995
28
Reduced activation of suppressor T lymphocytes by specific antigens in autoimmune thyroid disease. 61 54
8258649 1993
29
Serum thyroglobulin level in patients with diffuse and nodular goiter, after therapeutic application of stable iodine. 61 54
1628693 1992
30
Lack of response of peripheral blood mononuclear cells to thyroid microsomal antigen in nontoxic nodular goiters. 61 54
2121217 1990
31
A contemporary analysis of goiters undergoing surgery in the United States. 61
31948703 2020
32
Association Between Thyroid Hormone Status and Trace Elements in Serum of Patients with Nodular Goiter. 61
31691192 2020
33
Effective Preoperative Plasmapheresis Treatment of Severe Hyperthyroidism in a Patient with Giant Toxic Nodular Goiter and Methimazole-Induced Agranulocytosis. 61
32545570 2020
34
[Nodular goiter]. 61
32548696 2020
35
Fixed 30 mCi 131I-iodine therapy without recombinant human thyroid-stimulating hormone stimulation as an attractive therapeutic alternative in nontoxic nodular goiter. 61
32427701 2020
36
MiR-7-5pand miR-451 as diagnostic biomarkers for papillary thyroid carcinoma in formalin-fixed paraffin-embedded tissues. 61
32539923 2020
37
Altered TEG Parameters Identify Hypercoagulablilty and are of Diagnosis Value for Papillary Thyroid Carcinoma Patients. 61
30235493 2020
38
Risk stratification for lateral involvement in papillary thyroid carcinoma patients with central lymph node metastasis. 61
31983029 2020
39
nPAsym: an open-source plugin for ImageJ to quantify nuclear shape asymmetry. 61
32544781 2020
40
ProGRP AS A NOVEL BIOMARKER FOR THE DIFFERENTIAL DIAGNOSIS OF MEDULLARY THYROID CARCINOMA IN PATIENTS WITH THYROID NODULES. 61
32045291 2020
41
Graves' Disease and Toxic Nodular Goiter, Aggravated by Duration of Hyperthyroidism, Are Associated with Alzheimer's and Vascular Dementia: A Registry-Based Long-Term Follow-Up of Two Large Cohorts. 61
31984866 2020
42
Incidence of thyroid disorders in the second decade of adequate iodine supply in Slovenia. 61
32377868 2020
43
Thyroid gland changes in patients with acromegaly. 61
32555993 2020
44
The significance of serum thyroglobulin measurement before and after the treatment of toxic nodular goiter with 131I. 61
31977753 2020
45
Thyroid Pathology in End-Stage Renal Disease Patients on Hemodialysis. 61
32340182 2020
46
Unusual case of radioactive iodine induced Graves disease with orbitopathy following total thyroidectomy in a patient with papillary thyroid microcarcinoma. 61
32293702 2020
47
DECREASE IN ACROMEGALY-ASSOCIATED THYROID ENLARGEMENT AFTER NORMALIZATION OF IGF-1 LEVELS: A PROSPECTIVE OBSERVATION AND IN VITRO STUDY. 61
31859554 2020
48
Severe Neutropenia and Agranulocytosis Related to Antithyroid Drugs: A Study of 30 Cases Managed in A Single Reference Center. 61
32204561 2020
49
Exosomal miRNAs are potential diagnostic biomarkers between malignant and benign thyroid nodules based on next-generation sequencing. 61
31560760 2020
50
Distant metastases from pathologically proven benign follicular nodules of the thyroid: clinicopathological features and predictors of long-term survival. 61
32189188 2020

Variations for Nodular Goiter

Expression for Nodular Goiter

Search GEO for disease gene expression data for Nodular Goiter.

Pathways for Nodular Goiter

Pathways related to Nodular Goiter according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 VEGFA TNFRSF9 TNFRSF4 RET LGALS3 IL6
2
Show member pathways
13.08 VEGFA TNFRSF9 TNFRSF4 RET IL6 ICAM1
3
Show member pathways
12.77 TSHR TPO TG SLC5A5 HRAS BRAF
4 12.69 VEGFA HRAS HGF FAS BRAF
5
Show member pathways
12.53 VEGFA IL6 HRAS HGF BRAF
6 12.53 VEGFA RET IL6 HRAS HGF FAS
7
Show member pathways
12.51 TNFRSF9 IL6 HRAS FAS CTLA4
8 12.45 TNFRSF9 TNFRSF4 LGALS3 FAS CTLA4
9
Show member pathways
12.32 VEGFA ICAM1 HRAS BRAF
10
Show member pathways
12.3 VEGFA TSHR TPO TG IL6 ICAM1
11 12.08 VEGFA HRAS HGF FAS BRAF
12 11.92 VEGFA KRT19 IL6 HGF
13 11.81 VEGFA IL6 ICAM1 HGF
14
Show member pathways
11.74 RET HRAS BRAF
15
Show member pathways
11.73 TNFRSF9 TNFRSF4 FAS
16 11.73 VEGFA IL6 ICAM1 HRAS
17 11.67 VEGFA HRAS BRAF
18 11.67 VEGFA IL6 ICAM1 CTLA4
19 11.63 TSHR HRAS BRAF
20
Show member pathways
11.59 VEGFA IL6 ICAM1
21 11.58 IL6 HGF CALCA
22
Show member pathways
11.56 TNFRSF9 TNFRSF4 BRAF
23 11.47 IL6 ICAM1 HGF
24 11.44 VEGFA RET HRAS
25 11.37 VEGFA HRAS BRAF
26 11.25 IL6 ICAM1 FAS
27 11.14 VEGFA TPO IL6 HGF
28
Show member pathways
11.13 VEGFA HRAS CRP
29 9.7 TSHR TPO TG SLC5A5

GO Terms for Nodular Goiter

Cellular components related to Nodular Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 TSHR TPO TNFRSF9 TNFRSF4 SLC5A5 RET
2 extracellular space GO:0005615 9.65 VEGFA TPO TG MIR199A1 LGALS3 IL6
3 external side of plasma membrane GO:0009897 9.55 TNFRSF9 TNFRSF4 ICAM1 FAS CTLA4
4 cell surface GO:0009986 9.17 VEGFA TSHR TPO TNFRSF4 LGALS3 ICAM1

Biological processes related to Nodular Goiter according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.78 VEGFA RET HRAS HGF
2 positive regulation of protein phosphorylation GO:0001934 9.73 VEGFA HRAS HGF FAS
3 positive regulation of gene expression GO:0010628 9.63 VEGFA RET IL6 HRAS CRP BRAF
4 positive chemotaxis GO:0050918 9.58 VEGFA LGALS3 HGF
5 monocyte chemotaxis GO:0002548 9.54 LGALS3 IL6 CALCA
6 positive regulation of immunoglobulin secretion GO:0051024 9.51 TNFRSF4 IL6
7 hormone biosynthetic process GO:0042446 9.49 TPO TG
8 negative regulation of lipid storage GO:0010888 9.46 IL6 CRP
9 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.43 ICAM1 HGF FAS
10 iodide transport GO:0015705 9.32 TG SLC5A5
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.26 VEGFA IL6 ICAM1 HGF
12 thyroid hormone generation GO:0006590 8.8 TPO TG SLC5A5

Molecular functions related to Nodular Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.35 TSHR TNFRSF9 RET ICAM1 FAS
2 chemoattractant activity GO:0042056 9.33 VEGFA LGALS3 HGF
3 tumor necrosis factor-activated receptor activity GO:0005031 9.26 TNFRSF4 FAS
4 protein-containing complex binding GO:0044877 9.17 TSHR KRT19 ICAM1 HRAS HGF CALCA

Sources for Nodular Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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