NLPHL
MCID: NDL021
MIFTS: 47

Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL)

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Nodular Lymphocyte Predominant Hodgkin Lymphoma

MalaCards integrated aliases for Nodular Lymphocyte Predominant Hodgkin Lymphoma:

Name: Nodular Lymphocyte Predominant Hodgkin Lymphoma 59 73
Nlphl 59

Characteristics:

Orphanet epidemiological data:

59
nodular lymphocyte predominant hodgkin lymphoma
Prevalence: 1-9/1000000 (Worldwide),<1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



Summaries for Nodular Lymphocyte Predominant Hodgkin Lymphoma

MalaCards based summary : Nodular Lymphocyte Predominant Hodgkin Lymphoma, also known as nlphl, is related to lymphoma, hodgkin, classic and t-cell/histiocyte rich large b cell lymphoma. An important gene associated with Nodular Lymphocyte Predominant Hodgkin Lymphoma is BCL6 (BCL6, Transcription Repressor), and among its related pathways/superpathways are NF-kappaB Signaling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include b cells, t cells and bone, and related phenotypes are hyperhidrosis and splenomegaly

Wikipedia : 76 Nodular lymphocyte predominant Hodgkin''s lymphoma (NLPHL) is an indolent CD20(+) form of... more...

Related Diseases for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Diseases related to Nodular Lymphocyte Predominant Hodgkin Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 lymphoma, hodgkin, classic 33.3 BCL6 PAX5
2 t-cell/histiocyte rich large b cell lymphoma 11.9
3 lymphoma 11.2
4 hodgkin's granuloma 10.7
5 b-cell lymphomas 10.7
6 diffuse large b-cell lymphoma 10.5
7 peripheral t-cell lymphoma 10.2
8 progressive transformation of germinal centers 10.2
9 kaposi sarcoma 10.1
10 li-fraumeni syndrome 10.1
11 anemia, autoimmune hemolytic 10.1
12 lymphoma, non-hodgkin, familial 10.1
13 li-fraumeni syndrome 2 10.1
14 acute liver failure 10.1
15 follicular lymphoma 10.1
16 hemolytic anemia 10.1
17 sarcoma 10.1
18 cauda equina syndrome 10.1
19 leiomyoma 10.1
20 polyradiculopathy 10.1
21 adult lymphoma 10.1
22 mycobacterium avium complex infections 10.1
23 warthin tumor 10.1
24 primary mediastinal large b-cell lymphoma 10.1
25 composite lymphoma 10.1 BCL6 PAX5
26 intraocular lymphoma 10.1 BCL6 PAX5
27 primary central nervous system lymphoma 10.1 BCL6 PAX5
28 multicentric castleman disease 10.1 BCL6 PAX5
29 castleman disease 10.1 BCL6 PAX5
30 mediastinal malignant lymphoma 10.0 BCL6 PAX5
31 lung lymphoma 10.0 BCL6 PAX5
32 splenic marginal zone lymphoma 10.0 BCL6 PAX5
33 angioimmunoblastic t-cell lymphoma 10.0 BCL6 PDCD1
34 reticulosarcoma 10.0 BCL6 PAX5
35 leukocyte disease 9.9 BCL6 PAX5
36 burkitt lymphoma 9.9 BCL6 PAX5 VIM
37 mantle cell lymphoma 9.9 BCL6 PAX5

Graphical network of the top 20 diseases related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:



Diseases related to Nodular Lymphocyte Predominant Hodgkin Lymphoma

Symptoms & Phenotypes for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Human phenotypes related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:

59 32 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000975
2 splenomegaly 59 32 occasional (7.5%) Occasional (29-5%) HP:0001744
3 hepatomegaly 59 32 occasional (7.5%) Occasional (29-5%) HP:0002240
4 fever 59 32 frequent (33%) Frequent (79-30%) HP:0001945
5 fatigue 59 32 occasional (7.5%) Occasional (29-5%) HP:0012378
6 immunodeficiency 59 32 hallmark (90%) Very frequent (99-80%) HP:0002721
7 pruritus 59 32 occasional (7.5%) Occasional (29-5%) HP:0000989
8 weight loss 59 32 occasional (7.5%) Occasional (29-5%) HP:0001824
9 anorexia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002039
10 breast carcinoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0003002
11 lymphadenopathy 59 32 hallmark (90%) Very frequent (99-80%) HP:0002716
12 abnormality of bone marrow cell morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0005561
13 b-cell lymphoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0012191
14 lymphoma 59 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.92 BCL6 IGF1 SGK1 VIM

MGI Mouse Phenotypes related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.72 BCL6 IGF1 PAX5 PDCD1 VIM
2 hematopoietic system MP:0005397 9.65 BCL6 IGF1 PAX5 PDCD1 VIM
3 immune system MP:0005387 9.55 BCL6 IGF1 PAX5 PDCD1 VIM
4 muscle MP:0005369 9.26 BCL6 IGF1 PDCD1 VIM
5 respiratory system MP:0005388 8.92 BCL6 IGF1 PDCD1 VIM

Drugs & Therapeutics for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Search Clinical Trials , NIH Clinical Center for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Genetic Tests for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Anatomical Context for Nodular Lymphocyte Predominant Hodgkin Lymphoma

MalaCards organs/tissues related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:

41
B Cells, T Cells, Bone, Bone Marrow, Lung, Colon, Heart

Publications for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Articles related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:

(show top 50) (show all 168)
# Title Authors Year
1
Coping With Knife: Postoperative Management of Nodular Lymphocyte Predominant Hodgkin Lymphoma. ( 29413265 )
2018
2
Long-term follow-up of 2 patients treated with <sup>90</sup> Y-rituximab radioimmunotherapy for relapse of nodular lymphocyte-predominant Hodgkin lymphoma. ( 29719928 )
2018
3
Unfavorable presentation but comparable outcome: Presentation and outcome of children with nodular lymphocyte predominant Hodgkin lymphoma from India. ( 29893471 )
2018
4
Surgeon Concordance in the Assessment of Resectability for Stage IA Nodular Lymphocyte Predominant Hodgkin Lymphoma. ( 29401099 )
2018
5
R-Bendamustine in the treatment of nodular lymphocyte-predominant Hodgkin lymphoma. ( 29537344 )
2018
6
Erratum: Lydia Visser et al. Characterization of the Microenvironment of Nodular Lymphocyte Predominant Hodgkin Lymphoma, Int. J. Mol. Sci. 2016, 17, 2127. ( 29351228 )
2018
7
Adult nodular lymphocyte-predominant Hodgkin lymphoma: treatment modality utilization and survival. ( 29479868 )
2018
8
Bone Marrow Involvement in Patients With Nodular Lymphocyte Predominant Hodgkin Lymphoma. ( 29309302 )
2018
9
High dose chemotherapy and autologous stem cell transplantation in nodular lymphocyte-predominant Hodgkin lymphoma: A retrospective study by the European society for blood and marrow transplantation-lymphoma working party. ( 28971503 )
2018
10
Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma. ( 30155322 )
2018
11
Modern principles in the management of nodular lymphocyte-predominant Hodgkin lymphoma. ( 30485408 )
2018
12
A high number of IgG4-positive plasma cells rules out nodular lymphocyte predominant Hodgkin lymphoma. ( 30259184 )
2018
13
Relapsed and refractory nodular lymphocyte-predominant Hodgkin lymphoma: an analysis from the German Hodgkin Study Group. ( 30064977 )
2018
14
Multiple Cavitary Lung Lesions in an Adolescent: Case Report of a Rare Presentation of Nodular Lymphocyte Predominant Hodgkin Lymphoma. ( 30102646 )
2018
15
A Case of Chemotherapy-Refractory "THRLBCL like Transformation of NLPHL" Successfully Treated with Lenalidomide. ( 29552367 )
2018
16
Nodular lymphocyte predominant Hodgkin lymphoma in USA between 2000 and 2014: an updated analysis based on the SEER data. ( 28737250 )
2017
17
GATA3 Immunohistochemical Staining in Hodgkin Lymphoma: Diagnostic Utility in Differentiating Classic Hodgkin Lymphoma From Nodular Lymphocyte Predominant Hodgkin Lymphoma and Other Mimicking Entities. ( 28877074 )
2017
18
Characterization and Purification of Neoplastic Cells of Nodular Lymphocyte Predominant Hodgkin Lymphoma from Lymph Nodes by Flow Cytometry and Flow Cytometric Cell Sorting. ( 27998726 )
2017
19
Variant histology nodular lymphocyte predominant Hodgkin lymphoma - a route to transformation? ( 28369705 )
2017
20
Nodular lymphocyte-predominant Hodgkin lymphoma: a unique disease deserving unique management. ( 29222274 )
2017
21
Variant histology, IgD and CD30 expression in low-risk pediatric nodular lymphocyte predominant Hodgkin lymphoma: A report from the Children's Oncology Group. ( 28802087 )
2017
22
T-cell rosettes in nodular lymphocyte-predominant Hodgkin lymphoma. ( 28183747 )
2017
23
Nodular Lymphocyte-Predominant Hodgkin Lymphoma in Progressive Transformation of Germinal Centers. ( 29348956 )
2017
24
Advanced stage nodular lymphocyte predominant Hodgkin lymphoma in children and adolescents: clinical characteristics and treatment outcome - a report from the SFCE &amp;amp; CCLG groups. ( 28220934 )
2017
25
Nodular Lymphocyte Predominant Hodgkin Lymphoma: A Real-world Case Series of Consecutive Patients Treated by a Single Multidisciplinary Team in the East of England From 1999 to 2015. ( 28935378 )
2017
26
Nodular Lymphocyte-predominant Hodgkin Lymphoma in a 15-Year-Old Boy With Li-Fraumeni Syndrome Having a Germline TP53 D49H Mutation. ( 28902083 )
2017
27
J chain and myocyte enhancer factor 2B are useful in differentiating classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. ( 28851661 )
2017
28
Nodular lymphocyte predominant Hodgkin lymphoma in Sweden between 2000 and 2014: an analysis of the Swedish Lymphoma Registry. ( 28233899 )
2017
29
Rituximab in a risk-adapted treatment strategy gives excellent therapeutic results in nodular lymphocyte-predominant Hodgkin lymphoma. ( 28737231 )
2017
30
Cyclin D1 expression and polysomy in lymphocyte-predominant cells of nodular lymphocyte-predominant Hodgkin lymphoma. ( 28038705 )
2017
31
Nodular Lymphocyte Predominant Hodgkin Lymphoma of the Ileum. ( 29230339 )
2017
32
Encouraging activity for R-CHOP in Advanced Stage Nodular Lymphocyte Predominant Hodgkin Lymphoma. ( 28522441 )
2017
33
R-CHOP in NLPHL: who should receive it? ( 28751354 )
2017
34
Large B-cell transformation in nodular lymphocyte-predominant Hodgkin lymphoma: 40-year experience from a single institution. ( 26837698 )
2016
35
A strong host response and lack of MYC expression are characteristic for diffuse large B cell lymphoma transformed from nodular lymphocyte predominant Hodgkin lymphoma. ( 27708232 )
2016
36
Characterization of the Microenvironment of Nodular Lymphocyte Predominant Hodgkin Lymphoma. ( 27999289 )
2016
37
Atypical variants of nodular lymphocyte predominant Hodgkin lymphoma show low microvessel density and vessels of distention type. ( 27816718 )
2016
38
Nodular Lymphocyte Predominant Hodgkin Lymphoma Presenting with Unilateral Orbital Involvement. ( 27015240 )
2016
39
Nodular lymphocyte-predominant Hodgkin lymphoma. ( 27496311 )
2016
40
An unusual clinical and pathological presentation of a nodular lymphocyte predominant Hodgkin lymphoma (&amp;quot;Poppema Lennert&amp;quot; lymphoma). ( 27532537 )
2016
41
Relapsed or poorly responsive nodular lymphocyte predominant Hodgkin lymphoma in children and adolescents - a report from the United Kingdom's Children's Cancer and Leukaemia Study Group. ( 26996288 )
2016
42
A 20-year population-based study on the epidemiology, clinical features, treatment, and outcome of nodular lymphocyte predominant Hodgkin lymphoma. ( 26732883 )
2016
43
Complete remission following lenalidomide and rituximab in a patient with heavily pretreated nodular lymphocyte predominant Hodgkin lymphoma. ( 26762971 )
2016
44
A case of composite classical and nodular lymphocyte predominant Hodgkin lymphoma with progression to diffuse large B-cell non-Hodgkin lymphoma: Diagnostic difficulty in fine-needle aspiration cytology. ( 27888658 )
2016
45
Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma. ( 26658840 )
2016
46
Nodular Lymphocyte Predominant Hodgkin Lymphoma of the Thyroid. ( 28044111 )
2016
47
The role of tumour-infiltrating eosinophils, mast cells and macrophages in Classical and Nodular Lymphocyte Predominant Hodgkin Lymphoma in children. ( 26872637 )
2016
48
Rituximab plus ABVD in newly diagnosed nodular lymphocyte-predominant Hodgkin lymphoma. ( 26913966 )
2016
49
Diagnostic Utility of Flow Cytometry Analysis of Reactive T Cells in Nodular Lymphocyte-Predominant Hodgkin Lymphoma. ( 26712878 )
2016
50
Radiation for early-stage nodular lymphocyte-predominant Hodgkin lymphoma: a double-edged sword? ( 30179060 )
2016

Variations for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Expression for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Search GEO for disease gene expression data for Nodular Lymphocyte Predominant Hodgkin Lymphoma.

Pathways for Nodular Lymphocyte Predominant Hodgkin Lymphoma

GO Terms for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Biological processes related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.13 BCL6 IGF1 PDCD1
2 humoral immune response GO:0006959 8.62 PAX5 PDCD1

Sources for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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