NLPHL
MCID: NDL021
MIFTS: 49

Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL)

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Nodular Lymphocyte Predominant Hodgkin Lymphoma

MalaCards integrated aliases for Nodular Lymphocyte Predominant Hodgkin Lymphoma:

Name: Nodular Lymphocyte Predominant Hodgkin Lymphoma 60 74
Nlphl 60

Characteristics:

Orphanet epidemiological data:

60
nodular lymphocyte predominant hodgkin lymphoma
Prevalence: 1-9/1000000 (Worldwide),<1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



Summaries for Nodular Lymphocyte Predominant Hodgkin Lymphoma

MalaCards based summary : Nodular Lymphocyte Predominant Hodgkin Lymphoma, also known as nlphl, is related to lymphoma, hodgkin, classic and lymphoma. An important gene associated with Nodular Lymphocyte Predominant Hodgkin Lymphoma is BCL6 (BCL6 Transcription Repressor), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and T cell receptor signaling pathway. Affiliated tissues include bone, thyroid and t cells, and related phenotypes are immunodeficiency and lymphadenopathy

Wikipedia : 77 Nodular lymphocyte predominant Hodgkin''s lymphoma (NLPHL) is an indolent CD20(+) form of... more...

Related Diseases for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Diseases related to Nodular Lymphocyte Predominant Hodgkin Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 lymphoma, hodgkin, classic 33.4 BCL6 PAX5
2 lymphoma 31.5 BCL6 PAX5 REL
3 b-cell lymphomas 30.8 BCL6 PAX5 REL
4 diffuse large b-cell lymphoma 30.3 BCL6 REL
5 lymphoma, non-hodgkin, familial 29.9 BCL6 NOTCH1 PAX5
6 t-cell/histiocyte rich large b cell lymphoma 11.9
7 hodgkin's granuloma 10.8
8 peripheral t-cell lymphoma 10.3
9 progressive transformation of germinal centers 10.3
10 composite lymphoma 10.1 BCL6 PAX5
11 intraocular lymphoma 10.1 BCL6 PAX5
12 primary central nervous system lymphoma 10.1 BCL6 PAX5
13 multicentric castleman disease 10.1 BCL6 PAX5
14 kaposi sarcoma 10.1
15 li-fraumeni syndrome 10.1
16 anemia, autoimmune hemolytic 10.1
17 li-fraumeni syndrome 2 10.1
18 acute liver failure 10.1
19 anaplastic large cell lymphoma 10.1
20 follicular lymphoma 10.1
21 hemolytic anemia 10.1
22 sarcoma 10.1
23 leiomyoma 10.1
24 polyradiculopathy 10.1
25 adult lymphoma 10.1
26 mycobacterium avium complex infections 10.1
27 warthin tumor 10.1
28 rapidly involuting congenital hemangioma 10.1
29 primary mediastinal large b-cell lymphoma 10.1
30 castleman disease 10.1 BCL6 PAX5
31 lung lymphoma 10.1 BCL6 PAX5
32 plasmablastic lymphoma 10.1 BCL6 NOTCH1
33 splenic marginal zone lymphoma 10.0 BCL6 PAX5
34 reticulosarcoma 10.0 BCL6 PAX5
35 brachial plexus neuritis 10.0 NOTCH1 PDCD1
36 angioimmunoblastic t-cell lymphoma 10.0 BCL6 PDCD1
37 primary mediastinal b-cell lymphoma 10.0 BCL6 REL
38 leukocyte disease 9.9 BCL6 PAX5
39 lymphoblastic lymphoma 9.9 BCL6 NOTCH1
40 acute lymphocytic leukemia 9.8 NOTCH1 PAX5
41 mediastinal malignant lymphoma 9.8 BCL6 PAX5 REL
42 hematologic cancer 9.4 BCL6 NFKBIA NOTCH1 PAX5
43 leukemia, chronic lymphocytic 9.4 BCL6 NFKBIA NOTCH1 PAX5

Graphical network of the top 20 diseases related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:



Diseases related to Nodular Lymphocyte Predominant Hodgkin Lymphoma

Symptoms & Phenotypes for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Human phenotypes related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:

60 33 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 immunodeficiency 60 33 hallmark (90%) Very frequent (99-80%) HP:0002721
2 lymphadenopathy 60 33 hallmark (90%) Very frequent (99-80%) HP:0002716
3 fever 60 33 frequent (33%) Frequent (79-30%) HP:0001945
4 hyperhidrosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000975
5 splenomegaly 60 33 occasional (7.5%) Occasional (29-5%) HP:0001744
6 hepatomegaly 60 33 occasional (7.5%) Occasional (29-5%) HP:0002240
7 fatigue 60 33 occasional (7.5%) Occasional (29-5%) HP:0012378
8 pruritus 60 33 occasional (7.5%) Occasional (29-5%) HP:0000989
9 weight loss 60 33 occasional (7.5%) Occasional (29-5%) HP:0001824
10 anorexia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002039
11 breast carcinoma 60 33 occasional (7.5%) Occasional (29-5%) HP:0003002
12 abnormality of bone marrow cell morphology 60 33 occasional (7.5%) Occasional (29-5%) HP:0005561
13 b-cell lymphoma 60 33 occasional (7.5%) Occasional (29-5%) HP:0012191
14 lymphoma 60 Very frequent (99-80%)

MGI Mouse Phenotypes related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 BCL6 NFKBIA NOTCH1 PAX5 PDCD1 REL
2 growth/size/body region MP:0005378 9.88 BCL6 NFKBIA NOTCH1 PAX5 PDCD1 REL
3 hematopoietic system MP:0005397 9.85 BCL6 NFKBIA NOTCH1 PAX5 PDCD1 REL
4 immune system MP:0005387 9.8 BCL6 NFKBIA NOTCH1 PAX5 PDCD1 REL
5 mortality/aging MP:0010768 9.63 BCL6 NFKBIA NOTCH1 PAX5 PDCD1 REL
6 liver/biliary system MP:0005370 9.56 BCL6 NOTCH1 PDCD1 REL
7 normal MP:0002873 9.35 BCL6 NFKBIA NOTCH1 PAX5 REL
8 respiratory system MP:0005388 8.92 BCL6 NOTCH1 PDCD1 REL

Drugs & Therapeutics for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Search Clinical Trials , NIH Clinical Center for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Genetic Tests for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Anatomical Context for Nodular Lymphocyte Predominant Hodgkin Lymphoma

MalaCards organs/tissues related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:

42
Bone, Thyroid, T Cells, Breast, B Cells, Bone Marrow, Lung

Publications for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Articles related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:

(show top 50) (show all 3104)
# Title Authors Year
1
Psychosocial Experiences of Young Adults Diagnosed With Acute Leukemia During Hospitalization for Induction Chemotherapy Treatment. ( 30829935 )
2019
2
Lung fluid biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis. ( 30755248 )
2019
3
Fracture Resistance of Titanium, Zirconia, and Ceramic-Reinforced Polyetheretherketone Implant Abutments Supporting CAD/CAM Monolithic Lithium Disilicate Ceramic Crowns After Aging. ( 30716141 )
2019
4
Phase transition and hardness evolution of a Ti-5Al-5Mo-1Fe-1Cr alloy subjected to isothermal aging. ( 30223177 )
2019
5
Validation of CD137 Immunohistochemical Stain on Paraffin-Embedded Tissue as a Marker to Facilitate Distinction Between Classic Hodgkin Lymphoma, Nodular Lymphocyte-Predominant Hodgkin Lymphoma, T-Cell/Histiocyte-Rich Large B-Cell Lymphoma, and Anaplastic Large Cell Lymphoma. ( 30816829 )
2019
6
Is early appendectomy in adults diagnosed with acute appendicitis mandatory? A prospective study. ( 30651750 )
2019
7
Polymethoxylated Flavones Target Cancer Stemness and Improve the Antiproliferative Effect of 5-Fluorouracil in a 3D Cell Model of Colorectal Cancer. ( 30717428 )
2019
8
Krüppel-Like Factor 1 Gene Mutations in Thalassemia Patients from North Iran: Report of a New Mutation Associated with β-Thalassemia Intermedia. ( 30747024 )
2019
9
Hb Knossos (HBB: c.82G > T), β-globin CD 5 (-CT) (HBB: c.17_18delCT) and δ-globin CD 59 (-a) (HBD: c.179delA) mutations in a Syrian patient with β-thalassemia intermedia. ( 30777047 )
2019
10
Molecular characterization of β-thalassemia intermedia in the West Bank, Palestine. ( 30820323 )
2019
11
GC-MS Metabolomics Reveals Distinct Profiles of Low- and High-Grade Bladder Cancer Cultured Cells. ( 30669322 )
2019
12
Moderate to severe gambling problems and traumatic brain injury: A population-based study. ( 30832188 )
2019
13
Traumatic brain injury and hazardous/harmful drinking: Concurrent and single associations with poor mental health and roadway aggression. ( 30611965 )
2019
14
Advanced airway interventions for paediatric cardiac arrest: a systematic review and meta-analysis. ( 30862528 )
2019
15
Femtosecond laser-assisted cataract surgery for the white cataract. ( 29907631 )
2019
16
Are there any solutions for improving the cleft area hygiene in patients with cleft lip and palate? A systematic review. ( 30697916 )
2019
17
Experiences of caregivers of people with dementia in a Korean dementia simulation program. ( 30626192 )
2019
18
Digital depression screening in HIV primary care in South Africa: mood in retroviral + application monitoring [MIR + IAM]. ( 30854218 )
2019
19
Gender differences in loneliness, anger, depression, self-management ability and biomarkers of chronic illness in chronically ill mid-life adults in Appalachia. ( 30683252 )
2019
20
Interplay Between Helicobacter pylori Infection, Interleukin-11, and Leukemia Inhibitory Factor in Gastric Cancer Among Egyptian Patients, by Sabry D, Abdelaleem OO, Hefzy EM, Ibrahim AA, Ahmed TI, Hassan EA, Abdel-Hameed ND, Khalil MAF. J Interferon Cytokine Res 2018;38(11):517-525. DOI: 10.1089/jir.2018.0065. ( 30794008 )
2019
21
Predictors of survival outcome following radical gastrectomy for gastric cancer. ( 30690932 )
2019
22
Headache: an important symptom possibly linked to white matter lesions in thalassaemia. ( 30836423 )
2019
23
Determinants of Hepatitis C Treatment Adherence and Treatment Completion Among Veterans in the Direct Acting Antiviral Era. ( 30903364 )
2019
24
Disparities in uptake of direct-acting antiviral Therapy for Hepatitis C among people who inject drugs in a Canadian setting. ( 30653809 )
2019
25
The successful scale-up of direct-acting antiviral hepatitis C treatments will benefit from concerted investments in implementation science. ( 30623357 )
2019
26
Minute Ventilation During Hypoxia is Augmented with Capsaicin Supplementation in Aged Mice. ( 30904671 )
2019
27
Human cardiac progenitor cell activation and regeneration mechanisms: exploring a novel myocardial ischemia/reperfusion in vitro model. ( 30845956 )
2019
28
Ultra-high-dose methylcobalamin in amyotrophic lateral sclerosis: a long-term phase II/III randomised controlled study. ( 30636701 )
2019
29
FDA Approval Summary: Ivosidenib for relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-1 mutation. ( 30692099 )
2019
30
Treatment patterns and comparative analysis of non-intensive regimens in elderly acute myeloid leukemia patients-a real-world experience from India. ( 30697642 )
2019
31
Procedural Recommendations for Lymphoscintigraphy in the Diagnosis of Peripheral Lymphedema: the Genoa Protocol. ( 30828401 )
2019
32
Active surveillance for nodular lymphocyte-predominant Hodgkin lymphoma. ( 30770396 )
2019
33
Chemical composition, in vitro gas production, methane production and fatty acid profile of canola silage (Brassica napus) with four levels of molasses. ( 30820744 )
2019
34
Relationship between muscle inflammation and fat replacement assessed by MRI in facioscapulohumeral muscular dystrophy. ( 30778707 )
2019
35
Brown tumor diagnosed three years after parathyroidectomy in a patient with nail-patella syndrome: A case report. ( 30627596 )
2019
36
Opioid Use in Pregnant Women and Neonatal Abstinence Syndrome-A Review of the Literature. ( 30781484 )
2019
37
How Patients of Oral Cancer Cope Up with Impact of the Disease? A Qualitative Study in Central India. ( 30820111 )
2019
38
Preliminary study on a novel minimally invasive extra-articular implant for unicompartmental knee osteoarthritis. ( 30852111 )
2019
39
Efficacy and safety of gyejigachulbutang (Gui-Zhi-Jia-Shu-Fu-Tang, Keishikajutsubuto, TJ-18) for knee pain in patients with degenerative knee osteoarthritis: a randomized, placebo-controlled, patient and assessor blinded clinical trial. ( 30782208 )
2019
40
A 3D Printed Porous Titanium Alloy Rod with Diamond Crystal Lattice for Treatment of the Early-Stage Femoral Head Osteonecrosis in Sheep. ( 30911283 )
2019
41
Development of a Transcriptional Amplification System Based on the PEG3 Promoter to Target Androgen Receptor-Positive and -Negative Prostate Cancer Cells. ( 30626088 )
2019
42
Facilitators of healthy life style behaviors in persons with schizophrenia-A qualitative feasibility pilot study. ( 30658242 )
2019
43
Prevalence of extramedullary hematopoiesis, renal cysts, splenic and hepatic lesions, and vertebral hemangiomas among thalassemic patients: a retrospective study from the Myocardial Iron Overload in Thalassemia (MIOT) network. ( 30891614 )
2019
44
Role of 18F-FCH PET/CT to detect structural relapse in high risk Differentiated Thyroid Cancer patients. ( 30864903 )
2019
45
Community-level chlamydial serology for assessing trachoma elimination in trachoma-endemic Niger. ( 30689671 )
2019
46
Sensitivity and specificity of computer vision classification of eyelid photographs for programmatic trachoma assessment. ( 30742639 )
2019
47
Various Manifestations Of Trachoma In Internally Displaced Rural Population - A Free Eye Camp Based Survey. ( 30868779 )
2019
48
BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease. ( 30893882 )
2019
49
Molecular evidence of field cancerization initiated by diabetes in colon cancer patients. ( 30628165 )
2019
50
Simultaneous Determination of Size and Position of Silver and Gold Nanoparticles in Onion Cells using Laser Ablation-ICP-MS. ( 30864441 )
2019

Variations for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Expression for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Search GEO for disease gene expression data for Nodular Lymphocyte Predominant Hodgkin Lymphoma.

Pathways for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Pathways related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.22 BCL6 NFKBIA REL
2
Show member pathways
12.02 NFKBIA PDCD1 REL
3
Show member pathways
11.95 BCL6 NFKBIA REL
4
Show member pathways
11.87 BCL6 NFKBIA REL
5 11.77 BCL6 PAX5 REL
6
Show member pathways
11.66 NFKBIA NOTCH1 REL
7
Show member pathways
11.65 NFKBIA REL
8
Show member pathways
11.56 NFKBIA REL
9 11.54 BCL6 NFKBIA PAX5 PDCD1 REL
10
Show member pathways
11.44 NFKBIA REL
11 11.42 NFKBIA REL
12
Show member pathways
11.36 NFKBIA REL
13
Show member pathways
11.28 NFKBIA REL
14 11.27 NFKBIA REL
15
Show member pathways
11.22 NFKBIA REL
16 11.14 NFKBIA REL
17 11.09 NFKBIA REL
18 10.95 NFKBIA PDCD1
19
Show member pathways
10.91 NFKBIA REL
20 10.86 BCL6 PAX5 PDCD1
21 10.3 NFKBIA REL

GO Terms for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Cellular components related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.02 BCL6 NFKBIA NOTCH1 PAX5 REL

Biological processes related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.71 NFKBIA NOTCH1 PAX5 REL
2 positive regulation of transcription, DNA-templated GO:0045893 9.7 NFKBIA NOTCH1 REL
3 negative regulation of apoptotic process GO:0043066 9.69 BCL6 NFKBIA PDCD1
4 spermatogenesis GO:0007283 9.67 BCL6 NOTCH1 PAX5
5 negative regulation of transcription by RNA polymerase II GO:0000122 9.56 BCL6 NOTCH1 PAX5 REL
6 positive regulation of apoptotic process GO:0043065 9.54 BCL6 NOTCH1 PDCD1
7 negative regulation of cell differentiation GO:0045596 9.48 BCL6 NOTCH1
8 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.46 NFKBIA REL
9 skeletal muscle cell differentiation GO:0035914 9.43 NOTCH1 PAX5
10 regulation of cell proliferation GO:0042127 9.33 BCL6 NFKBIA NOTCH1
11 negative regulation of Notch signaling pathway GO:0045746 9.32 BCL6 NFKBIA
12 response to muramyl dipeptide GO:0032495 8.96 NFKBIA NOTCH1
13 humoral immune response GO:0006959 8.8 NOTCH1 PAX5 PDCD1

Molecular functions related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin DNA binding GO:0031490 9.16 BCL6 NOTCH1
2 chromatin binding GO:0003682 9.13 BCL6 NOTCH1 REL
3 DNA-binding transcription factor activity GO:0003700 8.92 BCL6 NOTCH1 PAX5 REL

Sources for Nodular Lymphocyte Predominant Hodgkin Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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