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MCID: NDL001
MIFTS: 35

Nodular Malignant Melanoma

Categories: Cancer diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Nodular Malignant Melanoma

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MalaCards integrated aliases for Nodular Malignant Melanoma:

Name: Nodular Malignant Melanoma 12 15
Nodular Melanoma 12 53 73

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10047
NCIt 50 C4225
SNOMED-CT 68 2142002
UMLS 73 C0334424
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Summaries for Nodular Malignant Melanoma

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Disease Ontology : 12 A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule.

MalaCards based summary : Nodular Malignant Melanoma, also known as nodular melanoma, is related to melanoma and giant congenital nevus. An important gene associated with Nodular Malignant Melanoma is EXT2 (Exostosin Glycosyltransferase 2), and among its related pathways/superpathways are Ras signaling pathway and Cushing syndrome. The drugs Ganciclovir and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and brain.

Wikipedia : 76 Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

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Related Diseases for Nodular Malignant Melanoma

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Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 melanoma 10.5
2 giant congenital nevus 10.1 NRAS HRAS
3 benign struma ovarii 10.1 NRAS HRAS
4 schimmelpenning-feuerstein-mims syndrome 10.1 NRAS HRAS
5 ovarian melanoma 10.1 NRAS HRAS
6 marcus gunn phenomenon 10.1 NRAS HRAS
7 malignant struma ovarii 10.1 NRAS HRAS
8 fetal adenoma 10.1 NRAS HRAS
9 myelodysplastic myeloproliferative cancer 10.1 NRAS HRAS
10 melanocytic nevus syndrome, congenital 10.1 NRAS HRAS
11 meningeal melanocytoma 10.1 NRAS GNAQ
12 acneiform dermatitis 10.1 NRAS HRAS
13 mucosal melanoma 10.1 NRAS GNAQ
14 core binding factor acute myeloid leukemia 10.0 NRAS HRAS
15 conjunctival cancer 10.0 NRAS GNAQ ABCB5
16 malignant skin fibrous histiocytoma 10.0 NRAS HRAS
17 hidradenoma 10.0
18 spitz nevus 10.0
19 vulvar melanoma 10.0 NRAS HRAS EXT2
20 superficial spreading melanoma 10.0
21 liver angiosarcoma 10.0 NRAS HRAS
22 melanomatosis 10.0 NRAS HRAS GNAQ
23 malignant conjunctival melanoma 10.0 NRAS HRAS GNAQ
24 meningeal melanomatosis 10.0 NRAS HRAS GNAQ
25 central nervous system melanocytic neoplasm 10.0 NRAS HRAS GNAQ
26 malignant dermis tumor 10.0 NRAS HRAS
27 melanoma, cutaneous malignant 1 10.0 NRAS HRAS GNAQ
28 lentigo maligna melanoma 9.9
29 nevus, epidermal 9.9 NRAS HRAS
30 myeloma, multiple 9.9 NRAS HRAS DIS3
31 nodular hidradenoma 9.9
32 eccrine acrospiroma 9.9
33 psoriasis 9.9
34 acrospiroma 9.9
35 hypoxia 9.9
36 basal cell carcinoma 1 9.8
37 basal cell carcinoma 9.8
38 keratoacanthoma 9.8
39 pigmented basal cell carcinoma 9.8
40 acral lentiginous melanoma 9.8
41 skin melanoma 9.8

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:



Diseases related to Nodular Malignant Melanoma
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Symptoms & Phenotypes for Nodular Malignant Melanoma

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Drugs & Therapeutics for Nodular Malignant Melanoma

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Drugs for Nodular Malignant Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
2 Antiviral Agents Phase 1
3 Nucleic Acid Synthesis Inhibitors Phase 1
4 Anti-Infective Agents Phase 1
5 Ganciclovir triphosphate Phase 1
6 tyrosine Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
2 Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma Terminated NCT01120275 Phase 2 gamma-secretase/Notch signalling pathway inhibitor RO4929097
3 Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma Completed NCT00005057 Phase 1 ganciclovir
4 cKIT, BRAF/NRAS Mutations in Advanced Melanoma : Clinical Outcome in Response to Tyrosine-kinase Inhibitors - KitMel Project Completed NCT01543113 Not Applicable
5 Study of Families With Melanoma Recruiting NCT00445783

Search NIH Clinical Center for Nodular Malignant Melanoma

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Genetic Tests for Nodular Malignant Melanoma

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Anatomical Context for Nodular Malignant Melanoma

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MalaCards organs/tissues related to Nodular Malignant Melanoma:

41
Skin, Lymph Node, Brain, Liver, Myeloid
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Publications for Nodular Malignant Melanoma

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Articles related to Nodular Malignant Melanoma:

(show top 50) (show all 95)
# Title Authors Year
1
Comparison of 5 different scoring methods in the evaluation of inflammatory infiltration (tumor infiltrating lymphocytes - TILs) in superficial spreading and nodular melanoma. ( 30506645 )
2018
2
Complete amelanotic acral nodular melanoma. ( 30322988 )
2018
3
Red nodular melanoma of the penile foreskin: A case report and literature review. ( 30233796 )
2018
4
Comprehensive histopathological comparison of epidermotropic/dermal metastatic melanoma and primary nodular melanoma. ( 28881040 )
2018
5
Nodular Melanoma: A Histopathologic Entity? ( 29182796 )
2018
6
Desmoplastic transformation of a nodular melanoma arising from a speckled lentiginous nevus. ( 29464760 )
2018
7
Nodular melanoma presenting as an exophytic subungual mass. ( 29911502 )
2018
8
Polypoid melanoma: an aggressive variant of nodular melanoma. ( 30063786 )
2018
9
Improving the early diagnosis of early nodular melanoma: can we do better? ( 30079779 )
2018
10
Nodular melanoma is less likely than superficial spreading melanoma to be histologically associated with a naevus. ( 29020904 )
2017
11
Performance of the "if in doubt, cut it out" rule for the management of nodular melanoma. ( 29085713 )
2017
12
Case of nodular melanoma on the upper eyelid dermoscopically mimicking pigmented basal cell carcinoma. ( 27649925 )
2016
13
Dermoscopy of Nodular Melanoma: Review of the Literature and Report of 3 Cases. ( 27663921 )
2016
14
Rare nodular malignant melanoma of the heel in the Caribbean: A case report. ( 28012339 )
2016
15
BRAF-V600E expression in primary nodular melanoma is associated with aggressive tumour features and reduced survival. ( 26924424 )
2016
16
Nodular melanoma in trophic ulceration of a leprosy patient: a case study. ( 27169340 )
2016
17
Case report of nodular melanoma within congenital melanocytic nevus- primary closure challenge. ( 26826932 )
2016
18
Nodular Melanoma. ( 26989291 )
2016
19
BRAF and NRAS mutations are heterogeneous and not mutually exclusive in nodular melanoma. ( 24710085 )
2015
20
RSK1 activation promotes invasion in nodular melanoma. ( 25579842 )
2015
21
An assessment of clinical pathways and missed opportunities for the diagnosis of nodular melanoma versus superficial spreading melanoma. ( 26563931 )
2015
22
Vaginal Amelanotic Nodular Malignant Melanoma in A Middle-Aged Female: A Rare Case Report and Review of Literature. ( 26085744 )
2015
23
Nodular Melanoma Arising in a Large Segmental Speckled Lentiginous Nevus. ( 25072686 )
2015
24
Nodular melanoma serendipitously detected by airport full body scanners. ( 25501134 )
2015
25
Cellular localization of CIP2A determines its prognostic impact in superficial spreading and nodular melanoma. ( 25663244 )
2015
26
Pigmented nodular melanoma: the predictive value of dermoscopic features using multivariate analysis. ( 25916655 )
2015
27
Nodular malignant melanoma. Or maybe not? ( 24635092 )
2014
28
EGFR and cyclin D1 in nodular melanoma: correlation with pathohistological parameters and overall survival. ( 25304234 )
2014
29
Individual and ecological factors associated with early detection of nodular melanoma in the United States. ( 24500502 )
2014
30
Nodular melanoma on the hyponychium: clinical and dermoscopic features. ( 24765666 )
2014
31
Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology. ( 24855580 )
2014
32
Spontaneously regressing primary nodular melanoma of the glans penis. ( 25372268 )
2014
33
Nodular melanoma: a distinct clinical entity and the largest contributor to melanoma deaths in Victoria, Australia. ( 23182058 )
2013
34
Dermoscopic evaluation of nodular melanoma. ( 23553375 )
2013
35
Nodular Melanoma Mimicking Keratoacanthoma: Lessons to learn. ( 22912931 )
2012
36
Superficial spreading and nodular melanoma are distinct biological entities: a challenge to the linear progression model. ( 22108608 )
2012
37
Prognostic importance of the mitotic marker phosphohistone H3 in cutaneous nodular melanoma. ( 22297638 )
2012
38
Nodular melanoma arising in a patient treated with anti-tumor necrosis factor alpha antagonists. ( 22416995 )
2012
39
An extensive primary nodular melanoma of the foot with associated distant metastases: a case report. ( 22560192 )
2012
40
Key points in the dermoscopic diagnosis of hypomelanotic melanoma and nodular melanoma. ( 21175750 )
2011
41
Unexpected detection of nodular melanoma of the skin on the scalp by I-123 IBZM brain SPECT. ( 21220985 )
2011
42
Small nodular melanoma: the beginning of a life-threatening lesion. A clinical study on 11 cases. ( 21528661 )
2011
43
Blue-black rule: a simple dermoscopic clue to recognize pigmented nodular melanoma. ( 21916885 )
2011
44
Late diagnosis of nodular melanoma of the foot in a 74-year-old Brazilian man. ( 22446655 )
2011
45
Nestin is expressed in HMB-45 negative melanoma cells in dermal parts of nodular melanoma. ( 20536663 )
2010
46
Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. ( 21390477 )
2010
47
Historical, clinical, and dermoscopic characteristics of thin nodular melanoma. ( 20231503 )
2010
48
Pigmented poroid neoplasm mimicking nodular melanoma. ( 20536669 )
2010
49
"The malignant wart": a review of primary nodular melanoma of the foot and report of two cases. ( 20605563 )
2010
50
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. ( 19550360 )
2009
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Variations for Nodular Malignant Melanoma

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Expression for Nodular Malignant Melanoma

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Search GEO for disease gene expression data for Nodular Malignant Melanoma.
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Pathways for Nodular Malignant Melanoma

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Pathways related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Ras signaling pathway 37
Show member pathways
 12.42 EFNA1 GNAQ HRAS NRAS
2
Cushing syndrome 37
Show member pathways
 12.19 GNAQ HRAS NRAS
3
Axon guidance 37
11.98 EFNA1 HRAS NRAS
4
Long-term potentiation 37
Show member pathways
 11.92 GNAQ HRAS NRAS
5
Apelin signaling pathway 37
11.81 GNAQ HRAS NRAS
6
UVA-Induced MAPK Signaling 64
Show member pathways
 11.78 GNAQ HRAS NRAS
7
Sphingolipid signaling pathway 37
11.68 GNAQ HRAS NRAS
8
Serotonergic synapse 37
11.64 GNAQ HRAS NRAS
9
MAP Kinase Signaling 4
11.6 GNAQ HRAS NRAS
10
Gap junction 37
11.38 GNAQ HRAS NRAS
11
Aryl Hydrocarbon Receptor 1
11.3 HRAS NRAS
12
Vemurafenib Pathway, Pharmacodynamics 61
11.24 HRAS NRAS
13
G-protein signaling_RhoA regulation pathway 22
11.15 EFNA1 GNAQ HRAS NRAS
14
Arf6 signaling events 1
11.14 EFNA1 GNAQ
15
BDNF-TrkB Signaling 1
11.13 HRAS NRAS
16
Extracellular vesicle-mediated signaling in recipient cells 1
11.07 HRAS NRAS
17
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 1
11.06 HRAS NRAS
18
Bisphosphonate Pathway, Pharmacodynamics 61
Show member pathways
 11.04 HRAS NRAS
19
EGFR Transactivation by Gastrin 66
Show member pathways
 10.98 HRAS NRAS
20
MNAR-PELP1 and Estrogen Receptor Interaction 64
10.91 HRAS NRAS
21
Transcription_Transcription factor Tubby signaling pathways 22
10.91 GNAQ HRAS NRAS
22
Long-term depression 37
10.91 GNAQ HRAS NRAS
23
CD209 (DC-SIGN) signaling 66
10.88 HRAS NRAS
24
p38MAPK events 66
10.57 HRAS NRAS
25
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling 1
10.1 GNAQ HRAS NRAS
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GO Terms for Nodular Malignant Melanoma

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Cellular components related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 8.92 EXT2 HRAS NRAS SEC23IP
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Sources for Nodular Malignant Melanoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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