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MCID: NDL001
MIFTS: 39

Nodular Malignant Melanoma

Categories: Cancer diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Nodular Malignant Melanoma

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MalaCards integrated aliases for Nodular Malignant Melanoma:

Name: Nodular Malignant Melanoma 12 15
Nodular Melanoma 12 53 17 72

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10047
NCIt 50 C4225
SNOMED-CT 68 2142002
UMLS 72 C0334424
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Summaries for Nodular Malignant Melanoma

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Disease Ontology : 12 A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule.

MalaCards based summary : Nodular Malignant Melanoma, also known as nodular melanoma, is related to skin melanoma and acral lentiginous melanoma. An important gene associated with Nodular Malignant Melanoma is EXT2 (Exostosin Glycosyltransferase 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Ganciclovir and Nucleic Acid Synthesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and brain, and related phenotypes are neoplasm and pigmentation

Wikipedia : 75 Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

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Related Diseases for Nodular Malignant Melanoma

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Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 skin melanoma 30.1 NRAS CDKN2A BRAF
2 acral lentiginous melanoma 29.8 NRAS CDKN2A BRAF
3 spitz nevus 29.5 HRAS CDKN2A BRAF
4 melanoma 10.5
5 conjunctival cancer 10.5 NRAS ABCB5
6 giant congenital nevus 10.4 NRAS HRAS
7 benign struma ovarii 10.4 NRAS HRAS
8 superficial spreading melanoma 10.4
9 schimmelpenning-feuerstein-mims syndrome 10.4 NRAS HRAS
10 ovarian melanoma 10.4 NRAS HRAS
11 malignant conjunctival melanoma 10.4 NRAS HRAS
12 marcus gunn phenomenon 10.3 NRAS HRAS
13 malignant struma ovarii 10.3 NRAS HRAS
14 fetal adenoma 10.3 NRAS HRAS
15 melanocytic nevus syndrome, congenital 10.3 NRAS HRAS
16 acneiform dermatitis 10.3 NRAS HRAS
17 erdheim-chester disease 10.3 NRAS BRAF
18 core binding factor acute myeloid leukemia 10.2 NRAS HRAS
19 malignant skin fibrous histiocytoma 10.2 NRAS HRAS
20 mucosal melanoma 10.2 NRAS BRAF
21 vulvar melanoma 10.2 NRAS HRAS EXT2
22 liver angiosarcoma 10.2 NRAS HRAS
23 malignant dermis tumor 10.1 NRAS HRAS
24 meningeal melanocytoma 10.1 NRAS CDKN2A
25 lentigines 10.1
26 basal cell carcinoma 10.1
27 lentigo maligna melanoma 10.1
28 gallbladder adenoma 10.1 HRAS CDKN2A
29 leopard syndrome 10.1 HRAS BRAF
30 histiocytic sarcoma 10.0 CDKN2A BRAF
31 skin carcinoma 10.0
32 nasal cavity adenocarcinoma 10.0 HRAS CDKN2A
33 bladder squamous cell carcinoma 10.0 CDKN2A BRAF
34 seizures, scoliosis, and macrocephaly/microcephaly syndrome 10.0
35 ovarian serous cystadenocarcinoma 9.9 NRAS HRAS BRAF
36 leukemia, chronic lymphocytic 2 9.9 NRAS HRAS BRAF
37 differentiated thyroid carcinoma 9.9 NRAS HRAS BRAF
38 pigmented basal cell carcinoma 9.9
39 amelanotic melanoma 9.9
40 renal cell carcinoma, papillary, 1 9.9 NRAS HRAS BRAF
41 thyroid cancer, nonmedullary, 2 9.9 NRAS HRAS BRAF
42 nodular hidradenoma 9.9
43 hidradenoma 9.9
44 pustulosis of palm and sole 9.9
45 eccrine acrospiroma 9.9
46 clear cell hidradenoma 9.9
47 psoriasis 9.9
48 acrospiroma 9.9
49 melanomatosis 9.9 NRAS HRAS CDKN2A
50 meningeal melanomatosis 9.9 NRAS HRAS CDKN2A

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:



Diseases related to Nodular Malignant Melanoma
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Symptoms & Phenotypes for Nodular Malignant Melanoma

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MGI Mouse Phenotypes related to Nodular Malignant Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.35 BRAF CDKN2A GON4L HRAS NRAS
2 pigmentation MP:0001186 8.92 ABCB5 BRAF CDKN2A NRAS
Sources

Drugs & Therapeutics for Nodular Malignant Melanoma

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Drugs for Nodular Malignant Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
2 Nucleic Acid Synthesis Inhibitors Phase 1
3 Ganciclovir triphosphate Phase 1
4 Antiviral Agents Phase 1
5 Anti-Infective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I Study of Intralesional Administration of an Adenovirus Vector Expressing the HSV-1 Thymidine Kinase Gene (AdV.RSV-TK) in Combination With Escalating Doses of Ganciclovir in Patients With Cutaneous Metastatic Malignant Melanoma Completed NCT00005057 Phase 1 ganciclovir
2 Melanoma Family Case-Control Study Protocol Recruiting NCT00445783

Search NIH Clinical Center for Nodular Malignant Melanoma

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Genetic Tests for Nodular Malignant Melanoma

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Anatomical Context for Nodular Malignant Melanoma

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MalaCards organs/tissues related to Nodular Malignant Melanoma:

41
Skin, Lymph Node, Brain, Lung, Bone, Kidney, Bone Marrow
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Publications for Nodular Malignant Melanoma

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Articles related to Nodular Malignant Melanoma:

(show top 50) (show all 582)
# Title Authors PMID Year
1
Paediatric melanoma: clinical update, genetic basis, and advances in diagnosis. 38
31204309 2019
2
IRF4 rs12203592*T/T genotype is associated with nodular melanoma. 38
31246726 2019
3
Reproductive factors and risk of melanoma: a population-based cohort study. 38
30748007 2019
4
Histopathologic variables differentially affect melanoma survival by age at diagnosis. 38
30706692 2019
5
Frequency of mutations in BRAF, NRAS, and KIT in different populations and histological subtypes of melanoma: a systemic review. 38
31274706 2019
6
A retrospective study of malignant melanoma from a tertiary care centre in Saudi Arabia from 2004 to 2016. 38
31256363 2019
7
A nomogram for predicting survival in patients with nodular melanoma: A population-based study. 38
31192966 2019
8
Matrical carcinoma with melanocytic hyperplasia mimicking nodular melanoma in an elderly Mexican male. 38
30785652 2019
9
Two synchronous malignancies: nodular melanoma and renal cell carcinoma in a patient with an underlying germline BRCA2 mutation. 38
31227566 2019
10
Amelanotic melanoma. 38
30672881 2019
11
Comparison of five different scoring methods in the evaluation of inflammatory infiltration (tumor-infiltrating lymphocytes) in superficial spreading and nodular melanoma. 38
30506645 2019
12
Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma. 38
30932370 2019
13
Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma. 38
30449771 2019
14
Balloon Cell Primary Nodular Melanoma: Dermoscopy Evidence. 38
31106022 2019
15
[A man with a skin lesion on the big toe]. 38
30875165 2019
16
The incidence of melanoma in South Africa: An exploratory analysis of National Cancer Registry data from 2005 to 2013 with a specific focus on melanoma in black Africans. 38
31084690 2019
17
Distinct clinicopathological and prognostic features of thin nodular primary melanomas: an international study from 17 centers. 38
30863861 2019
18
Primary Melanoma Histologic Subtype: Impact on Survival and Response to Therapy. 38
29912415 2019
19
In situ and invasive melanoma in a high-risk, New Zealand, population: A population-based study. 38
30051460 2019
20
Clinical experience with combination BRAF/MEK inhibitors for melanoma with brain metastases: a real-life multicenter study. 38
30376465 2019
21
Nodular Melanoma in an African American Female. 38
31019646 2019
22
A Rare Cause of Uveitis: Vemurafenib 38
30605942 2018
23
Risk Factors for Regional and Systemic Metastases in Patients with Sentinel Lymph Node-negative Melanoma. 38
30396988 2018
24
Complete amelanotic acral nodular melanoma. 38
30322988 2018
25
Improving the early diagnosis of early nodular melanoma: can we do better? 38
30079779 2018
26
Red nodular melanoma of the penile foreskin: A case report and literature review. 38
30233796 2018
27
Frequency of BRAF V600E Mutation in the Mexican Population of Patients With Metastatic Melanoma. 38
30241212 2018
28
Dermatoscopy of Neoplastic Skin Lesions: Recent Advances, Updates, and Revisions. 38
30238167 2018
29
Epidemiological trends in the diagnosis of melanoma in a Southern European population: analysis of a large database from a tertiary referral center. 38
29762190 2018
30
High serum vitamin D level correlates with better prognostic indicators in primary melanoma: A pilot study. 38
28332194 2018
31
Desmoplastic transformation of a nodular melanoma arising from a speckled lentiginous nevus. 38
29464760 2018
32
An Ulcerated Reddish Nodule of the Chest: When You See, Think …. 38
30345275 2018
33
Differences in the diagnosis of primary cutaneous melanoma in the public and private healthcare systems in Joinville, Santa Catarina State, Brazil. 38
30066755 2018
34
Polypoid melanoma: an aggressive variant of nodular melanoma. 38
30063786 2018
35
Association of Skin Examination Behaviors and Thinner Nodular vs Superficial Spreading Melanoma at Diagnosis. 38
29710122 2018
36
Raised vulvar lesions: be aware! 38
29785335 2018
37
Nodular Melanoma: A Histopathologic Entity? 38
29182796 2018
38
Acral melanoma: correlating the clinical presentation to the mutational status. 38
29512974 2018
39
Malignant Melanoma of the Nipple: A Case Report. 38
29628990 2018
40
One Step Melanoma Surgery for Patient with Thick Primary Melanomas: "To Break the Rules, You Must First Master Them!" 38
29531606 2018
41
Nodular melanoma presenting as an exophytic subungual mass. 38
29911502 2018
42
Comprehensive histopathological comparison of epidermotropic/dermal metastatic melanoma and primary nodular melanoma. 38
28881040 2018
43
Are prognostic indices for brain metastases of melanoma still valid in the stereotactic era? 38
29316943 2018
44
Nucleoli cytomorphology in cutaneous melanoma cells - a new prognostic approach to an old concept. 38
29284501 2017
45
Clinicopathological predictors of recurrence in nodular and superficial spreading cutaneous melanoma: a multivariate analysis of 214 cases. 38
29115977 2017
46
Nodular melanoma is less likely than superficial spreading melanoma to be histologically associated with a naevus. 38
29020904 2017
47
Prognostic role of the histological subtype of melanoma on the hands and feet in Caucasians. 38
28296711 2017
48
Performance of the "if in doubt, cut it out" rule for the management of nodular melanoma. 38
29085713 2017
49
Case of nodular melanoma on the upper eyelid dermoscopically mimicking pigmented basal cell carcinoma. 38
27649925 2017
50
Patients' Characteristics, Histopathological Findings, and Tumor Stage in Different Types of Malignant Melanoma: A Retrospective Multicenter Study. 38
28724272 2017
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Variations for Nodular Malignant Melanoma

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Expression for Nodular Malignant Melanoma

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Search GEO for disease gene expression data for Nodular Malignant Melanoma.
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Pathways for Nodular Malignant Melanoma

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Pathways related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Endometrial cancer 37
Show member pathways
 12.67 NRAS HRAS CDKN2A BRAF
2
Pathways in cancer 37
12.64 NRAS HRAS CDKN2A BRAF
3
Gastric cancer 37
Show member pathways
 12.52 NRAS HRAS CDKN2A BRAF
4
Glioma 37
Show member pathways
 12.45 NRAS HRAS CDKN2A BRAF
5
B cell receptor signaling pathway (KEGG) 1
Show member pathways
 12.24 NRAS HRAS BRAF
6
CNTF Signaling 64
Show member pathways
 12.17 NRAS HRAS BRAF
7
Paradoxical activation of RAF signaling by kinase inactive BRAF 66
Show member pathways
 12.14 NRAS HRAS BRAF
8
Proteoglycans in cancer 37
12.14 NRAS HRAS BRAF
9
Viral carcinogenesis 37
12.13 NRAS HRAS CDKN2A
10
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 12.1 NRAS HRAS BRAF
11
Signaling by FGFR2 66
Show member pathways
 12.1 NRAS HRAS BRAF
12
Long-term potentiation 37
Show member pathways
 12 NRAS HRAS BRAF
13
Cellular senescence (KEGG) 37
11.97 NRAS HRAS CDKN2A
14
mTOR Pathway 71
Show member pathways
 11.97 NRAS HRAS BRAF
15
NGF Pathway 64
Show member pathways
 11.93 NRAS HRAS BRAF
16
FoxO signaling pathway 37
Show member pathways
 11.85 NRAS HRAS BRAF
17
Oncogenic MAPK signaling 66
Show member pathways
 11.83 NRAS HRAS BRAF
18
Serotonergic synapse 37
11.75 NRAS HRAS BRAF
19
DNA Damage Response (only ATM dependent) 1
11.73 NRAS HRAS CDKN2A
20
MAP Kinase Signaling 4
11.69 NRAS HRAS BRAF
21
Senescence and Autophagy in Cancer 1
11.63 HRAS CDKN2A BRAF
22
VEGF Pathway (Tocris) 61
Show member pathways
 11.5 NRAS HRAS BRAF
23
Negative regulation of MAPK pathway 66
Show member pathways
 11.36 NRAS HRAS BRAF
24
Glioblastoma Multiforme 64
11.3 NRAS HRAS CDKN2A BRAF
25
Long-term depression 37
11.28 NRAS HRAS BRAF
26
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 1
11.12 NRAS HRAS
27
Extracellular vesicle-mediated signaling in recipient cells 1
11.12 NRAS HRAS
28
Bisphosphonate Pathway, Pharmacodynamics 61
Show member pathways
 11.1 NRAS HRAS
29
Vemurafenib Pathway, Pharmacodynamics 61
11.07 NRAS HRAS BRAF
30
EGFR Transactivation by Gastrin 66
Show member pathways
 11.04 NRAS HRAS
31
MNAR-PELP1 and Estrogen Receptor Interaction 64
10.97 NRAS HRAS
32
CD209 (DC-SIGN) signaling 66
10.94 NRAS HRAS
33
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling 1
10.88 NRAS HRAS
34
BDNF-TrkB Signaling 1
10.85 NRAS HRAS BRAF
35
Bladder cancer 37 1
10.79 NRAS HRAS CDKN2A BRAF
36
p38MAPK events 66
10.59 NRAS HRAS
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GO Terms for Nodular Malignant Melanoma

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Cellular components related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 8.92 SEC23IP NRAS HRAS EXT2

Biological processes related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.33 NRAS HRAS BRAF
2 cellular senescence GO:0090398 8.96 HRAS CDKN2A
3 Ras protein signal transduction GO:0007265 8.8 NRAS HRAS CDKN2A
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Sources for Nodular Malignant Melanoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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