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MCID: NDL001
MIFTS: 42

Nodular Malignant Melanoma

Categories: Rare diseases, Cancer diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Nodular Malignant Melanoma

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MalaCards integrated aliases for Nodular Malignant Melanoma:

Name: Nodular Malignant Melanoma 12 15
Nodular Melanoma 12 53 73

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10047
NCIt 50 C4225
SNOMED-CT 68 2142002 254731001
UMLS 73 C0334424
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Summaries for Nodular Malignant Melanoma

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Disease Ontology : 12 A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule.

MalaCards based summary : Nodular Malignant Melanoma, also known as nodular melanoma, is related to herpetiform pemphigus and multicentric osteolysis, nodulosis, and arthropathy. An important gene associated with Nodular Malignant Melanoma is XPR1 (Xenotropic And Polytropic Retrovirus Receptor 1), and among its related pathways/superpathways are Pathways in cancer and Degradation of the extracellular matrix. The drugs Ganciclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and lymph node, and related phenotypes are shRNA abundance <= 50% and homeostasis/metabolism

Wikipedia : 76 Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

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Related Diseases for Nodular Malignant Melanoma

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Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 herpetiform pemphigus 10.4 DSG1 DSG3
2 multicentric osteolysis, nodulosis, and arthropathy 10.4 MMP14 MMP2
3 melanoma 10.4
4 winchester syndrome 10.4 MMP14 MMP2
5 spastic entropion 10.4 MMP1 MMP2
6 bullous impetigo 10.3 DSG1 DSG3
7 pulmonary emphysema 10.3 HMOX1 MMP1 TIMP2
8 fibromatosis, gingival, 1 10.3 MMP1 MMP2
9 internal hemorrhoid 10.2 MMP1 MMP2
10 light chain deposition disease 10.2 MMP1 MMP14 MMP2
11 pneumothorax 10.2 BLVRA HMOX1 MMP2
12 conjunctivochalasis 10.2 MMP1 MMP2 TIMP2
13 adenomyosis 10.2 MMP1 MMP2 TIMP2
14 varicose veins 10.1 MMP1 MMP2 TIMP2
15 lymphangioleiomyomatosis 10.1 MMP1 MMP14 MMP2
16 ischemic colitis 10.1 HMOX1 MMP2
17 inguinal hernia 10.1 MMP1 MMP2 TIMP2
18 klatskin's tumor 10.0 MMP14 MMP2
19 periodontal disease 9.9 MMP1 MMP2 TIMP2
20 actinic keratosis 9.9 CDKN2A MMP14 MMP2
21 hidradenoma 9.9
22 spitz nevus 9.9
23 nasal cavity squamous cell carcinoma 9.9 CDKN2A MMP2 TIMP2
24 aortic aneurysm, familial abdominal, 1 9.9 MMP1 MMP14 MMP2 TIMP2
25 fibrosarcoma 9.8 MMP1 MMP14 MMP2 TIMP2
26 li-fraumeni syndrome 9.8 ATM CDKN1A CDKN2A
27 tongue cancer 9.8 CDKN1A CDKN2A MMP2
28 aging 9.7
29 squamous cell carcinoma 9.7
30 nodular hidradenoma 9.7
31 vaginitis 9.7
32 eccrine acrospiroma 9.7
33 psoriasis 9.7
34 acrospiroma 9.7
35 hypoxia 9.7
36 endotheliitis 9.7
37 microcystic meningioma 9.7 MMP2 TIMP2
38 gastrointestinal system cancer 9.6 CDKN1A CDKN2A MMP2
39 squamous cell carcinoma, head and neck 9.5 CDKN2A MMP1 MMP14 MMP2
40 skin melanoma 9.5 CDKN1A CDKN2A MMP2
41 conjunctival nevus 9.4 MMP2 WDFY2
42 ovarian cancer 9.0 ATM CDKN1A ITGB3 MMP14 MMP2 TIMP2

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:



Diseases related to Nodular Malignant Melanoma
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Symptoms & Phenotypes for Nodular Malignant Melanoma

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GenomeRNAi Phenotypes related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.32 ATM BLVRA CDKN1A DPP4 HMOX1 ITGB3

MGI Mouse Phenotypes related to Nodular Malignant Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 MMP14 MMP2 TIMP2 DPP4 MMP1 DSG3
2 immune system MP:0005387 10.11 MMP14 MMP2 TIMP2 XPR1 MMP1 ATM
3 cardiovascular system MP:0005385 10.09 MMP14 MMP2 TIMP2 ATM HMOX1 CDKN1A
4 adipose tissue MP:0005375 9.93 MMP14 DSG1 DSG3 ATM HMOX1 CDKN1A
5 integument MP:0010771 9.92 MMP14 DSG1 ATM DSG3 CDKN1A HMOX2
6 muscle MP:0005369 9.8 MMP14 MMP2 ITGB3 HMOX1 CDKN1A HMOX2
7 neoplasm MP:0002006 9.63 MMP2 CDKN2A ITGB3 MMP1 ATM CDKN1A
8 respiratory system MP:0005388 9.56 MMP14 MMP2 DSG3 HMOX1 CDKN1A HMOX2
9 vision/eye MP:0005391 9.17 MMP14 MMP2 CDKN2A ITGB3 DSG1 DSG3
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Drugs & Therapeutics for Nodular Malignant Melanoma

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Drugs for Nodular Malignant Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
2 Anti-Infective Agents Phase 1
3 Antiviral Agents Phase 1
4 Ganciclovir triphosphate Phase 1
5 Nucleic Acid Synthesis Inhibitors Phase 1
6 tyrosine Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
2 Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma Terminated NCT01120275 Phase 2 gamma-secretase/Notch signalling pathway inhibitor RO4929097
3 Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma Completed NCT00005057 Phase 1 ganciclovir
4 cKIT, BRAF/NRAS Mutations in Advanced Melanoma : Clinical Outcome in Response to Tyrosine-kinase Inhibitors - KitMel Project Completed NCT01543113 Not Applicable
5 Study of Families With Melanoma Recruiting NCT00445783

Search NIH Clinical Center for Nodular Malignant Melanoma

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Genetic Tests for Nodular Malignant Melanoma

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Anatomical Context for Nodular Malignant Melanoma

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MalaCards organs/tissues related to Nodular Malignant Melanoma:

41
Skin, Endothelial, Lymph Node
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Publications for Nodular Malignant Melanoma

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Articles related to Nodular Malignant Melanoma:

(show all 39)
# Title Authors Year
1
Nodular melanoma is less likely than superficial spreading melanoma to be histologically associated with a naevus. ( 29020904 )
2017
2
Case of nodular melanoma on the upper eyelid dermoscopically mimicking pigmented basal cell carcinoma. ( 27649925 )
2016
3
Dermoscopy of Nodular Melanoma: Review of the Literature and Report of 3 Cases. ( 27663921 )
2016
4
Rare nodular malignant melanoma of the heel in the Caribbean: A case report. ( 28012339 )
2016
5
BRAF-V600E expression in primary nodular melanoma is associated with aggressive tumour features and reduced survival. ( 26924424 )
2016
6
Nodular melanoma in trophic ulceration of a leprosy patient: a case study. ( 27169340 )
2016
7
BRAF and NRAS mutations are heterogeneous and not mutually exclusive in nodular melanoma. ( 24710085 )
2015
8
RSK1 activation promotes invasion in nodular melanoma. ( 25579842 )
2015
9
An assessment of clinical pathways and missed opportunities for the diagnosis of nodular melanoma versus superficial spreading melanoma. ( 26563931 )
2015
10
Vaginal Amelanotic Nodular Malignant Melanoma in A Middle-Aged Female: A Rare Case Report and Review of Literature. ( 26085744 )
2015
11
Nodular malignant melanoma. Or maybe not? ( 24635092 )
2014
12
EGFR and cyclin D1 in nodular melanoma: correlation with pathohistological parameters and overall survival. ( 25304234 )
2014
13
Nodular Melanoma Mimicking Keratoacanthoma: Lessons to learn. ( 22912931 )
2012
14
Nestin is expressed in HMB-45 negative melanoma cells in dermal parts of nodular melanoma. ( 20536663 )
2010
15
SOX10 expression in superficial spreading and nodular malignant melanomas. ( 20890226 )
2010
16
Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. ( 21390477 )
2010
17
TRPM1 (Melastatin-1/MLSN1) mRNA expression in Spitz nevi and nodular melanomas. ( 19396153 )
2009
18
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. ( 19550360 )
2009
19
Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. ( 18319032 )
2008
20
Nodular malignant melanoma with Spitz nevus-like pathological features finally confirmed by the pathological feature of the sentinel lymph node. ( 18078408 )
2007
21
Increased C-MYC copy numbers on the background of CDKN2A loss is associated with improved survival in nodular melanoma. ( 16977458 )
2007
22
BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival. ( 16098042 )
2005
23
Extra copies of c-myc are more pronounced in nodular melanomas than in superficial spreading melanomas as revealed by fluorescence in situ hybridisation. ( 15221868 )
2004
24
Immunohistochemical study of melanocytic differentiation antigens in cutaneous malignant melanoma. A comparison of six commercial antibodies and one non-commercial antibody in nodular melanoma, superficially spreading melanoma and lentigo maligna melanoma. ( 15233017 )
2004
25
Altered expression of cell cycle regulators Cyclin D1, p14, p16, CDK4 and Rb in nodular melanomas. ( 15547691 )
2004
26
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. ( 14512791 )
2003
27
c-MYC and nodular malignant melanoma. A case report. ( 10897006 )
2000
28
Digital occurrence of nodular malignant melanoma. ( 9110528 )
1997
29
Nodular malignant melanoma - Secondary to carcinoma rectum. ( 20944369 )
1997
30
p53-protein and Ki-67-antigen expression are both reliable biomarkers of prognosis in thick stage I nodular melanomas of the skin. ( 9023558 )
1997
31
Nodular malignant melanoma. ( 1597831 )
1992
32
Differential expression of melanoma associated antigens in acral lentiginous melanoma and in nodular melanoma lesions. ( 1671829 )
1991
33
Factor XIIIa in nodular malignant melanoma and Spitz naevi. ( 1979912 )
1990
34
A comparative study of Spitz nevus and nodular malignant melanoma using image analysis cytometry. ( 3295064 )
1987
35
Nodular malignant melanoma and multiple squamous cell carcinomas in a patient treated by photochemotherapy for psoriasis. ( 6439287 )
1984
36
Nodular malignant melanoma of upper eyelid. ( 6470506 )
1984
37
Nodular malignant melanoma: a distinct entity or a common end stage? ( 7149203 )
1982
38
Clinical differentiation of adult-onset cavernous angioma from nodular malignant melanoma. ( 7369746 )
1980
39
Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma. ( 50762 )
1975
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Variations for Nodular Malignant Melanoma

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Expression for Nodular Malignant Melanoma

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Search GEO for disease gene expression data for Nodular Malignant Melanoma.
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Pathways for Nodular Malignant Melanoma

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Pathways related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Pathways in cancer 37
12.67 CDKN1A CDKN2A HMOX1 MMP1 MMP2
2
Degradation of the extracellular matrix 66
Show member pathways
 12.58 ITGB3 MMP1 MMP14 MMP2 TIMP2
3
MicroRNAs in cancer 37
12.28 ATM CDKN1A CDKN2A HMOX1 ITGB3
4
Colorectal Cancer Metastasis 64
12 CDKN1A MMP1 MMP14 MMP2
5
TGF-beta Signaling Pathway (WikiPathways) 1
11.89 CDKN1A ITGB3 MMP1
6
SMAD Signaling Network 64
11.88 ATM CDKN1A CDKN2A MMP2
7
Adhesion 4
11.84 ITGB3 MMP14 MMP2
8
DNA Damage Response (only ATM dependent) 1
11.8 ATM CDKN1A CDKN2A
9
Senescence and Autophagy in Cancer 1
11.76 CDKN1A CDKN2A MMP14
10
Interleukin-4 and 13 signaling 66
11.73 CDKN1A HMOX1 MMP1 MMP2
11
Matrix Metalloproteinases 1
Show member pathways
 11.62 MMP1 MMP14 MMP2 TIMP2
12
Platinum drug resistance 37
11.58 ATM CDKN1A CDKN2A
13
Angiogenesis (CST) 4
11.41 HMOX1 ITGB3 MMP2 TIMP2
14
Photodynamic therapy-induced AP-1 survival signaling. 1
11.39 CDKN1A CDKN2A MMP2
15
Integrated Cancer Pathway 1
11.3 ATM CDKN1A MMP1
16
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.14 HMOX1 MMP1 MMP2
17
Bladder cancer 37 1
11.12 CDKN1A CDKN2A MMP1 MMP2
18
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 66
10.91 MMP1 MMP2
19
TP53 Network 1
Show member pathways
 10.78 ATM CDKN1A CDKN2A
20
Cell adhesion_ECM remodeling 22
10.71 MMP1 MMP14 MMP2 TIMP2
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GO Terms for Nodular Malignant Melanoma

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Cellular components related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lamellipodium membrane GO:0031258 8.96 DPP4 ITGB3
2 extracellular matrix GO:0031012 8.92 MMP1 MMP14 MMP2 TIMP2

Biological processes related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.78 CDKN1A HMOX1 MMP1 MMP2
2 response to oxidative stress GO:0006979 9.69 HMOX1 HMOX2 MMP14
3 viral entry into host cell GO:0046718 9.58 DPP4 ITGB3 XPR1
4 extracellular matrix disassembly GO:0022617 9.56 MMP1 MMP14 MMP2 TIMP2
5 collagen catabolic process GO:0030574 9.54 MMP1 MMP14 MMP2
6 cellular senescence GO:0090398 9.52 CDKN1A CDKN2A
7 negative regulation of phosphorylation GO:0042326 9.49 CDKN1A CDKN2A
8 negative regulation of B cell proliferation GO:0030889 9.46 ATM CDKN2A
9 endothelial cell proliferation GO:0001935 9.43 HMOX1 MMP14
10 replicative senescence GO:0090399 9.33 ATM CDKN1A CDKN2A
11 heme oxidation GO:0006788 9.32 HMOX1 HMOX2
12 heme catabolic process GO:0042167 9.13 BLVRA HMOX1 HMOX2
13 response to hypoxia GO:0001666 9.1 ATM DPP4 HMOX1 HMOX2 MMP14 MMP2

Molecular functions related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.7 BLVRA CDKN1A DSG1 DSG3 HMOX1 HMOX2
2 integrin binding GO:0005178 9.61 ITGB3 MMP14 TIMP2
3 metalloendopeptidase activity GO:0004222 9.58 MMP1 MMP14 MMP2
4 serine-type endopeptidase activity GO:0004252 9.56 DPP4 MMP1 MMP14 MMP2
5 protease binding GO:0002020 9.54 DPP4 ITGB3 TIMP2
6 virus receptor activity GO:0001618 9.33 DPP4 ITGB3 XPR1
7 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.32 CDKN1A CDKN2A
8 heme oxygenase (decyclizing) activity GO:0004392 8.62 HMOX1 HMOX2
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Sources for Nodular Malignant Melanoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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