MCID: NDL001
MIFTS: 44

Nodular Malignant Melanoma

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Nodular Malignant Melanoma

MalaCards integrated aliases for Nodular Malignant Melanoma:

Name: Nodular Malignant Melanoma 12 15
Nodular Melanoma 12 52 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10047
NCIt 49 C4225
SNOMED-CT 67 2142002
UMLS 71 C0334424

Summaries for Nodular Malignant Melanoma

Disease Ontology : 12 A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule.

MalaCards based summary : Nodular Malignant Melanoma, also known as nodular melanoma, is related to lentigo maligna melanoma and pigmented basal cell carcinoma. An important gene associated with Nodular Malignant Melanoma is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Ganciclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and lymph node, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

Related Diseases for Nodular Malignant Melanoma

Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 lentigo maligna melanoma 30.8 MLANA MITF MC1R
2 pigmented basal cell carcinoma 30.5 MLANA MITF
3 spitz nevus 30.5 HRAS CDKN2A BRAF
4 lentigines 30.1 MC1R BRAF
5 acral lentiginous melanoma 29.9 NRAS KIT GNAQ EXT2 CDKN2A BRAF
6 amelanotic melanoma 29.5 TYR MLANA MITF KIT BRAF
7 basal cell carcinoma 29.1 TYR MC1R KIT CDKN2A CCND1
8 skin carcinoma 28.9 TYR NRAS MLANA MC1R MAP2K7 HRAS
9 skin melanoma 28.5 TYR NRAS MLANA MITF MC1R MAP2K7
10 renal cell carcinoma, nonpapillary 28.1 TYR NRAS MITF KIT HRAS CCND1
11 sarcoma 28.1 NRAS MTAP KIT HRAS CDK4 CCND1
12 neuroblastoma 27.7 TYR NRAS MAP2K7 KIT HRAS CDKN2A
13 melanoma 26.2 TYR NRAS MTAP MLANA MITF MC1R
14 anal canal paget's disease 10.5 MLANA CDKN2A
15 trachea carcinoma in situ 10.5 HRAS CDKN2A
16 uterus perivascular epithelioid cell tumor 10.5 MLANA MITF
17 vagina leiomyosarcoma 10.5 MLANA KIT
18 phakomatosis cesioflammea 10.5 GNAQ GNA11
19 anus basaloid carcinoma 10.5 KIT CDKN2A
20 thymoma, familial 10.5 KIT HRAS
21 cervical adenoid cystic carcinoma 10.5 KIT CDKN2A
22 selection of therapeutic option in colorectal cancer 10.5 NRAS BRAF
23 melphalan allergy 10.5 NRAS BRAF
24 malignant choroid melanoma 10.5 MLANA MITF
25 small intestine leiomyoma 10.5 MLANA KIT
26 spitzoid melanoma 10.5 HRAS BRAF
27 jejunal neoplasm 10.4 MLANA KIT
28 heart leiomyosarcoma 10.4 KIT CDKN2A
29 sensory organ benign neoplasm 10.4 NRAS MLANA GNAQ
30 core binding factor acute myeloid leukemia 10.4 NRAS KIT HRAS
31 histiocytic sarcoma 10.4 CDKN2A BRAF
32 keratosis 10.4 MC1R HRAS CDKN2A
33 mediastinum liposarcoma 10.4 CDKN2A CDK4
34 melanotic neurilemmoma 10.4 MLANA GNAQ
35 superficial spreading melanoma 10.4
36 cardiovascular cancer 10.4 MLANA MITF KIT
37 vascular cancer 10.4 MLANA MITF KIT
38 acneiform dermatitis 10.4 NRAS MAP2K7 HRAS
39 cutaneous ganglioneuroma 10.4 MITF KIT
40 nevus, epidermal 10.4 NRAS HRAS GNAQ
41 keratosis, seborrheic 10.4 MLANA MC1R CDKN2A
42 melanoma in congenital melanocytic nevus 10.4 NRAS MLANA BRAF
43 gallbladder melanoma 10.4 MLANA MITF MAP2K7
44 anus cancer 10.4 KIT HRAS CDKN2A
45 meningeal melanocytoma 10.4 MLANA GNAQ GNA11
46 mongolian spot 10.3 MLANA GNAQ GNA11
47 selection of therapeutic option in melanoma 10.3 NRAS KIT BRAF
48 benign struma ovarii 10.3 NRAS HRAS BRAF
49 schimmelpenning-feuerstein-mims syndrome 10.3 NRAS HRAS
50 serous cystadenocarcinoma 10.3 NRAS HRAS BRAF

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:



Diseases related to Nodular Malignant Melanoma

Symptoms & Phenotypes for Nodular Malignant Melanoma

GenomeRNAi Phenotypes related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.58 HRAS
2 Decreased viability GR00221-A-1 9.58 CDKN2A HRAS KIT MAP2K7 NRAS
3 Decreased viability GR00221-A-2 9.58 HRAS
4 Decreased viability GR00221-A-3 9.58 CDKN2A HRAS NRAS
5 Decreased viability GR00221-A-4 9.58 CDKN2A
6 Decreased viability GR00301-A 9.58 KIT
7 Decreased viability GR00342-S-1 9.58 MAP2K7
8 Decreased viability GR00402-S-2 9.58 CDKN2A HRAS KIT MAP2K7 NRAS
9 Decreased substrate adherent cell growth GR00193-A-1 9.56 KIT
10 Decreased substrate adherent cell growth GR00193-A-2 9.56 CDK4 KIT
11 Decreased substrate adherent cell growth GR00193-A-3 9.56 BRAF CDK4
12 Decreased substrate adherent cell growth GR00193-A-4 9.56 BRAF CDK4 KIT

MGI Mouse Phenotypes related to Nodular Malignant Melanoma:

45 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.45 BRAF CCND1 CDK4 CDKN2A DIS3 GNA11
2 cardiovascular system MP:0005385 10.38 BRAF CCND1 CDK4 CDKN2A GNA11 GNAQ
3 integument MP:0010771 10.37 BRAF CCND1 CDK4 CDKN2A GNA11 GNAQ
4 homeostasis/metabolism MP:0005376 10.36 ABCB5 BRAF CCND1 CDK4 CDKN2A GNA11
5 endocrine/exocrine gland MP:0005379 10.35 BRAF CCND1 CDK4 CDKN2A GNA11 GNAQ
6 growth/size/body region MP:0005378 10.35 BRAF CCND1 CDK4 CDKN2A GNA11 GNAQ
7 mortality/aging MP:0010768 10.35 BRAF CCND1 CDK4 CDKN2A DIS3 EXT2
8 cellular MP:0005384 10.33 ABCB5 BRAF CCND1 CDK4 CDKN2A KIT
9 craniofacial MP:0005382 10.32 BRAF CCND1 CDK4 GNA11 GNAQ HRAS
10 immune system MP:0005387 10.31 BRAF CCND1 CDK4 CDKN2A GNA11 GNAQ
11 nervous system MP:0003631 10.21 ABCB5 BRAF CCND1 CDK4 CDKN2A GNA11
12 hearing/vestibular/ear MP:0005377 10.16 BRAF GNA11 GNAQ KIT MC1R MITF
13 neoplasm MP:0002006 10.16 BRAF CCND1 CDK4 CDKN2A HRAS KIT
14 limbs/digits/tail MP:0005371 10.11 BRAF GNA11 GNAQ KIT MC1R MITF
15 normal MP:0002873 10.11 BRAF CCND1 CDK4 GNA11 GNAQ HRAS
16 liver/biliary system MP:0005370 10.1 BRAF CDK4 CDKN2A GNA11 KIT MITF
17 pigmentation MP:0001186 10.1 ABCB5 BRAF CDK4 CDKN2A GNA11 GNAQ
18 no phenotypic analysis MP:0003012 10.06 CDKN2A HRAS KIT MC1R MITF MLANA
19 renal/urinary system MP:0005367 9.86 BRAF CDK4 GNA11 GNAQ HRAS KIT
20 respiratory system MP:0005388 9.76 BRAF CCND1 CDKN2A GNA11 GNAQ HRAS
21 skeleton MP:0005390 9.73 BRAF CCND1 CDK4 CDKN2A EXT2 GNA11
22 vision/eye MP:0005391 9.32 ABCB5 BRAF CCND1 CDK4 CDKN2A KIT

Drugs & Therapeutics for Nodular Malignant Melanoma

Drugs for Nodular Malignant Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
2 Anti-Infective Agents Phase 1
3 Antiviral Agents Phase 1
4 Ganciclovir triphosphate Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I Study of Intralesional Administration of an Adenovirus Vector Expressing the HSV-1 Thymidine Kinase Gene (AdV.RSV-TK) in Combination With Escalating Doses of Ganciclovir in Patients With Cutaneous Metastatic Malignant Melanoma Completed NCT00005057 Phase 1 ganciclovir
2 Melanoma Family Case-Control Study Protocol Recruiting NCT00445783

Search NIH Clinical Center for Nodular Malignant Melanoma

Genetic Tests for Nodular Malignant Melanoma

Anatomical Context for Nodular Malignant Melanoma

MalaCards organs/tissues related to Nodular Malignant Melanoma:

40
Skin, Thyroid, Lymph Node, Myeloid, Bone, Lung, Brain

Publications for Nodular Malignant Melanoma

Articles related to Nodular Malignant Melanoma:

(show top 50) (show all 593)
# Title Authors PMID Year
1
Frequency of mutations in BRAF, NRAS, and KIT in different populations and histological subtypes of melanoma: a systemic review. 61
31274706 2020
2
Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma. 61
31677173 2020
3
BRAF, KIT, and NRAS Mutations of Acral Melanoma in White Patients. 61
32017841 2020
4
Rapid Dermoscopic Changes in Nodular Melanoma. 61
31921503 2020
5
The anatomic distribution of cutaneous melanoma: A detailed study of 5141 lesions. 61
31880825 2019
6
[Melanoma within tattoos: Two cases and a systematic literature review]. 61
31812363 2019
7
Distinct Clinicopathological and Prognostic Features of Thin Nodular Primary Melanomas: An International Study from 17 Centers. 61
30863861 2019
8
Malignant Melanoma of the Vulva and Vagina: A US Population-Based Study of 1863 Patients. 61
31784896 2019
9
A comprehensive evaluation of pathogenic mutations in primary cutaneous melanomas, including the identification of novel loss-of-function variants. 61
31745173 2019
10
A preliminary study for quantitative assessment with HFUS (High Frequency ultrasound) of nodular skin melanoma Breslow thickness in adults before surgery: Interdisciplinary team experience. 61
31589132 2019
11
Predicting response to pembrolizumab in metastatic melanoma by a new personalization algorithm. 61
31590677 2019
12
Multiple Thick Nodular Melanoma: Differentiating Multiple Primaries from the Metastasis of a Previous Single Melanoma 61
31446748 2019
13
Acral melanoma: correlating the clinical presentation to the mutational status. 61
29512974 2019
14
Paediatric melanoma: clinical update, genetic basis, and advances in diagnosis. 61
31204309 2019
15
IRF4 rs12203592*T/T genotype is associated with nodular melanoma. 61
31246726 2019
16
Reproductive factors and risk of melanoma: a population-based cohort study. 61
30748007 2019
17
Histopathologic variables differentially affect melanoma survival by age at diagnosis. 61
30706692 2019
18
Amelanotic melanoma. 61
30672881 2019
19
Matrical carcinoma with melanocytic hyperplasia mimicking nodular melanoma in an elderly Mexican male. 61
30785652 2019
20
A nomogram for predicting survival in patients with nodular melanoma: A population-based study. 61
31192966 2019
21
A retrospective study of malignant melanoma from a tertiary care centre in Saudi Arabia from 2004 to 2016. 61
31256363 2019
22
Two synchronous malignancies: nodular melanoma and renal cell carcinoma in a patient with an underlying germline BRCA2 mutation. 61
31227566 2019
23
Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma. 61
30932370 2019
24
Comparison of five different scoring methods in the evaluation of inflammatory infiltration (tumor-infiltrating lymphocytes) in superficial spreading and nodular melanoma. 61
30506645 2019
25
Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma. 61
30449771 2019
26
Balloon Cell Primary Nodular Melanoma: Dermoscopy Evidence. 61
31106022 2019
27
[A man with a skin lesion on the big toe]. 61
30875165 2019
28
The incidence of melanoma in South Africa: An exploratory analysis of National Cancer Registry data from 2005 to 2013 with a specific focus on melanoma in black Africans. 61
31084690 2019
29
In situ and invasive melanoma in a high-risk, New Zealand, population: A population-based study. 61
30051460 2019
30
Clinical experience with combination BRAF/MEK inhibitors for melanoma with brain metastases: a real-life multicenter study. 61
30376465 2019
31
Primary Melanoma Histologic Subtype: Impact on Survival and Response to Therapy. 61
29912415 2019
32
Low BRAF V600 mutation prevalence in primary skin nodular melanoma in Indonesia: a real-time PCR detection among Javanese patients. 61
31890008 2019
33
Nodular Melanoma in an African American Female. 61
31019646 2019
34
A Rare Cause of Uveitis: Vemurafenib 61
30605942 2018
35
Risk Factors for Regional and Systemic Metastases in Patients with Sentinel Lymph Node-negative Melanoma. 61
30396988 2018
36
Improving the early diagnosis of early nodular melanoma: can we do better? 61
30079779 2018
37
Red nodular melanoma of the penile foreskin: A case report and literature review. 61
30233796 2018
38
Complete amelanotic acral nodular melanoma. 61
30322988 2018
39
Frequency of BRAF V600E Mutation in the Mexican Population of Patients With Metastatic Melanoma. 61
30241212 2018
40
Dermatoscopy of Neoplastic Skin Lesions: Recent Advances, Updates, and Revisions. 61
30238167 2018
41
High serum vitamin D level correlates with better prognostic indicators in primary melanoma: A pilot study. 61
28332194 2018
42
Epidemiological trends in the diagnosis of melanoma in a Southern European population: analysis of a large database from a tertiary referral center. 61
29762190 2018
43
Desmoplastic transformation of a nodular melanoma arising from a speckled lentiginous nevus. 61
29464760 2018
44
Differences in the diagnosis of primary cutaneous melanoma in the public and private healthcare systems in Joinville, Santa Catarina State, Brazil. 61
30066755 2018
45
An Ulcerated Reddish Nodule of the Chest: When You See, Think …. 61
30345275 2018
46
Polypoid melanoma: an aggressive variant of nodular melanoma. 61
30063786 2018
47
Association of Skin Examination Behaviors and Thinner Nodular vs Superficial Spreading Melanoma at Diagnosis. 61
29710122 2018
48
Raised vulvar lesions: be aware! 61
29785335 2018
49
Nodular Melanoma: A Histopathologic Entity? 61
29182796 2018
50
Malignant Melanoma of the Nipple: A Case Report. 61
29628990 2018

Variations for Nodular Malignant Melanoma

Expression for Nodular Malignant Melanoma

Search GEO for disease gene expression data for Nodular Malignant Melanoma.

Pathways for Nodular Malignant Melanoma

Pathways related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 NRAS MAP2K7 KIT HRAS GNA11 CDKN2A
2
Show member pathways
13.72 NRAS MAP2K7 KIT HRAS GNA11 CDKN2A
3
Show member pathways
13.23 NRAS MAP2K7 HRAS GNAQ GNA11 CCND1
4
Show member pathways
13.08 NRAS MAP2K7 HRAS GNAQ GNA11 CDK4
5
Show member pathways
12.85 NRAS MITF HRAS GNA11 BRAF
6
Show member pathways
12.83 NRAS KIT HRAS CDKN2A CDK4 CCND1
7
Show member pathways
12.82 NRAS MAP2K7 HRAS GNA11 BRAF
8
Show member pathways
12.81 NRAS KIT HRAS GNAQ GNA11 BRAF
9
Show member pathways
12.8 NRAS MAP2K7 HRAS GNAQ GNA11 CDKN2A
10 12.78 NRAS MAP2K7 KIT HRAS BRAF
11
Show member pathways
12.75 NRAS KIT HRAS GNAQ BRAF
12
Show member pathways
12.69 NRAS MAP2K7 HRAS GNAQ GNA11
13
Show member pathways
12.69 NRAS KIT HRAS CDKN2A CDK4 CCND1
14
Show member pathways
12.64 NRAS MAP2K7 HRAS CCND1 BRAF
15
Show member pathways
12.58 NRAS MAP2K7 HRAS GNAQ GNA11 CCND1
16
Show member pathways
12.52 NRAS MAP2K7 HRAS BRAF
17
Show member pathways
12.52 NRAS MITF MAP2K7 HRAS CDKN2A CDK4
18 12.43 MAP2K7 GNA11 CDK4 CCND1
19
Show member pathways
12.43 NRAS MITF MAP2K7 HRAS BRAF
20
Show member pathways
12.43 NRAS HRAS GNAQ GNA11 CCND1 BRAF
21
Show member pathways
12.41 NRAS MAP2K7 KIT HRAS BRAF
22 12.38 NRAS MITF KIT HRAS GNAQ GNA11
23
Show member pathways
12.34 HRAS GNAQ GNA11 CCND1
24 12.34 NRAS HRAS CDKN2A CDK4 CCND1
25 12.31 NRAS HRAS CCND1 BRAF
26 12.29 NRAS HRAS CDKN2A CDK4 CCND1
27
Show member pathways
12.23 NRAS MAP2K7 HRAS BRAF
28
Show member pathways
12.23 NRAS HRAS CDK4 CCND1 BRAF
29
Show member pathways
12.21 NRAS HRAS GNAQ BRAF
30
Show member pathways
12.17 TYR NRAS MITF MC1R KIT HRAS
31 12.13 NRAS HRAS CDKN2A CDK4 CCND1
32
Show member pathways
12.1 NRAS HRAS CCND1 BRAF
33 12.1 NRAS HRAS GNAQ CCND1
34
Show member pathways
12.08 NRAS HRAS GNAQ GNA11
35
Show member pathways
12.07 NRAS HRAS CDK4 CCND1
36 11.99 NRAS HRAS GNAQ BRAF
37 11.99 NRAS HRAS CDKN2A CCND1
38
Show member pathways
11.95 MAP2K7 HRAS GNAQ GNA11 BRAF
39 11.92 NRAS HRAS CDK4 CCND1
40 11.88 GNAQ GNA11 BRAF
41 11.88 NRAS MAP2K7 HRAS GNAQ BRAF
42 11.86 NRAS HRAS GNAQ GNA11
43
Show member pathways
11.81 NRAS KIT HRAS BRAF
44 11.79 NRAS KIT CCND1
45 11.78 NRAS HRAS CDKN2A CDK4 CCND1 BRAF
46 11.75 NRAS HRAS GNAQ GNA11 BRAF
47 11.73 NRAS KIT HRAS
48
Show member pathways
11.7 NRAS HRAS BRAF
49 11.7 HRAS GNAQ CDK4 BRAF
50 11.69 NRAS MITF HRAS

GO Terms for Nodular Malignant Melanoma

Biological processes related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.78 NRAS KIT HRAS BRAF
2 positive regulation of gene expression GO:0010628 9.77 MITF KIT HRAS CDKN2A BRAF
3 signal transduction GO:0007165 9.65 NRAS MC1R MAP2K7 KIT HRAS GNAQ
4 Ras protein signal transduction GO:0007265 9.61 NRAS HRAS CDKN2A
5 regulation of cell proliferation GO:0042127 9.56 MITF KIT CDK4 BRAF
6 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.54 GNAQ GNA11
7 melanin biosynthetic process GO:0042438 9.52 TYR MC1R
8 positive regulation of phospholipase C activity GO:0010863 9.51 KIT HRAS
9 developmental pigmentation GO:0048066 9.49 KIT GNA11
10 somatic stem cell division GO:0048103 9.46 KIT CDKN2A
11 phototransduction, visible light GO:0007603 9.4 GNAQ GNA11
12 entrainment of circadian clock GO:0009649 9.32 GNAQ GNA11
13 myeloid progenitor cell differentiation GO:0002318 9.16 KIT BRAF
14 pigmentation GO:0043473 8.92 TYR MITF MC1R KIT

Molecular functions related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TYR SEC23IP NRAS MTAP MLANA MITF
2 protein kinase activity GO:0004672 9.72 MAP2K7 KIT CDK4 CCND1 BRAF
3 nucleotide binding GO:0000166 9.65 NRAS KIT HRAS CDK4 BRAF
4 kinase activity GO:0016301 9.63 MAP2K7 KIT CDKN2A CDK4 CCND1 BRAF
5 type 2A serotonin receptor binding GO:0031826 8.62 GNAQ GNA11

Sources for Nodular Malignant Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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