MCID: NDL001
MIFTS: 35

Nodular Malignant Melanoma

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Nodular Malignant Melanoma

MalaCards integrated aliases for Nodular Malignant Melanoma:

Name: Nodular Malignant Melanoma 12 15
Nodular Melanoma 12 54 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10047
NCIt 51 C4225
SNOMED-CT 69 2142002
UMLS 74 C0334424

Summaries for Nodular Malignant Melanoma

Disease Ontology : 12 A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule.

MalaCards based summary : Nodular Malignant Melanoma, also known as nodular melanoma, is related to melanoma and giant congenital nevus. An important gene associated with Nodular Malignant Melanoma is EXT2 (Exostosin Glycosyltransferase 2), and among its related pathways/superpathways are Long-term potentiation and Apelin signaling pathway. The drugs Ganciclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and brain.

Wikipedia : 77 Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

Related Diseases for Nodular Malignant Melanoma

Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 melanoma 10.5
2 giant congenital nevus 10.2 HRAS NRAS
3 benign struma ovarii 10.2 HRAS NRAS
4 schimmelpenning-feuerstein-mims syndrome 10.2 HRAS NRAS
5 ovarian melanoma 10.2 HRAS NRAS
6 marcus gunn phenomenon 10.1 HRAS NRAS
7 malignant struma ovarii 10.1 HRAS NRAS
8 fetal adenoma 10.1 HRAS NRAS
9 myelodysplastic myeloproliferative cancer 10.1 HRAS NRAS
10 melanocytic nevus syndrome, congenital 10.1 HRAS NRAS
11 acneiform dermatitis 10.1 HRAS NRAS
12 malignant skin fibrous histiocytoma 10.0 HRAS NRAS
13 mucosal melanoma 10.0 GNAQ NRAS
14 hidradenoma 10.0
15 spitz nevus 10.0
16 meningeal melanocytoma 10.0 GNAQ NRAS
17 core binding factor acute myeloid leukemia 10.0 HRAS NRAS
18 superficial spreading melanoma 10.0
19 vulvar melanoma 10.0 EXT2 HRAS NRAS
20 liver angiosarcoma 10.0 HRAS NRAS
21 conjunctival cancer 9.9 ABCB5 GNAQ NRAS
22 lentigines 9.9
23 melanoma in congenital melanocytic nevus 9.9
24 lentigo maligna melanoma 9.9
25 malignant dermis tumor 9.9 HRAS NRAS
26 malignant conjunctival melanoma 9.9 GNAQ HRAS NRAS
27 melanomatosis 9.9 GNAQ HRAS NRAS
28 nodular hidradenoma 9.9
29 eccrine acrospiroma 9.9
30 psoriasis 9.9
31 acrospiroma 9.9
32 hypoxia 9.9
33 meningeal melanomatosis 9.9 GNAQ HRAS NRAS
34 central nervous system melanocytic neoplasm 9.9 GNAQ HRAS NRAS
35 melanoma, cutaneous malignant 1 9.8 GNAQ HRAS NRAS
36 nevus, epidermal 9.8 HRAS NRAS
37 myeloma, multiple 9.8 DIS3 HRAS NRAS
38 retinoblastoma 9.8
39 leprosy 3 9.8
40 basal cell carcinoma 1 9.8
41 basal cell carcinoma 9.8
42 keratoacanthoma 9.8
43 pigmented basal cell carcinoma 9.8
44 acral lentiginous melanoma 9.8
45 skin melanoma 9.8
46 hansen's disease 9.8

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:



Diseases related to Nodular Malignant Melanoma

Symptoms & Phenotypes for Nodular Malignant Melanoma

Drugs & Therapeutics for Nodular Malignant Melanoma

Drugs for Nodular Malignant Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
2 Anti-Infective Agents Phase 1
3 Antiviral Agents Phase 1
4 Nucleic Acid Synthesis Inhibitors Phase 1
5 Ganciclovir triphosphate Phase 1
6
Tyrosine Approved, Investigational, Nutraceutical Not Applicable 60-18-4 6057

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
2 Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma Terminated NCT01120275 Phase 2 gamma-secretase/Notch signalling pathway inhibitor RO4929097
3 Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma Completed NCT00005057 Phase 1 ganciclovir
4 cKIT, BRAF/NRAS Mutations in Advanced Melanoma : Clinical Outcome in Response to Tyrosine-kinase Inhibitors - KitMel Project Completed NCT01543113 Not Applicable
5 Study of Families With Melanoma Recruiting NCT00445783

Search NIH Clinical Center for Nodular Malignant Melanoma

Genetic Tests for Nodular Malignant Melanoma

Anatomical Context for Nodular Malignant Melanoma

MalaCards organs/tissues related to Nodular Malignant Melanoma:

42
Skin, Lymph Node, Brain, Myeloid

Publications for Nodular Malignant Melanoma

Articles related to Nodular Malignant Melanoma:

(show top 50) (show all 98)
# Title Authors Year
1
Matrical Carcinoma with Melanocytic Hyperplasia Mimicking Nodular Melanoma in an Elderly Mexican Male. ( 30785652 )
2019
2
Comparison of five different scoring methods in the evaluation of inflammatory infiltration (tumor-infiltrating lymphocytes) in superficial spreading and nodular melanoma. ( 30506645 )
2019
3
Balloon Cell Primary Nodular Melanoma: Dermoscopy Evidence. ( 31106022 )
2019
4
Nodular Melanoma in an African American Female. ( 31019646 )
2019
5
Desmoplastic transformation of a nodular melanoma arising from a speckled lentiginous nevus. ( 29464760 )
2018
6
Nodular Melanoma: A Histopathologic Entity? ( 29182796 )
2018
7
Comprehensive histopathological comparison of epidermotropic/dermal metastatic melanoma and primary nodular melanoma. ( 28881040 )
2018
8
Complete amelanotic acral nodular melanoma. ( 30322988 )
2018
9
Red nodular melanoma of the penile foreskin: A case report and literature review. ( 30233796 )
2018
10
Improving the early diagnosis of early nodular melanoma: can we do better? ( 30079779 )
2018
11
Polypoid melanoma: an aggressive variant of nodular melanoma. ( 30063786 )
2018
12
Nodular melanoma presenting as an exophytic subungual mass. ( 29911502 )
2018
13
Performance of the "if in doubt, cut it out" rule for the management of nodular melanoma. ( 29085713 )
2017
14
Case of nodular melanoma on the upper eyelid dermoscopically mimicking pigmented basal cell carcinoma. ( 27649925 )
2017
15
Rare nodular malignant melanoma of the heel in the Caribbean: A case report. ( 28012339 )
2017
16
Nodular melanoma is less likely than superficial spreading melanoma to be histologically associated with a naevus. ( 29020904 )
2017
17
Dermoscopy of Nodular Melanoma: Review of the Literature and Report of 3 Cases. ( 27663921 )
2016
18
Nodular Melanoma. ( 26989291 )
2016
19
BRAF-V600E expression in primary nodular melanoma is associated with aggressive tumour features and reduced survival. ( 26924424 )
2016
20
Case report of nodular melanoma within congenital melanocytic nevus- primary closure challenge. ( 26826932 )
2016
21
Nodular melanoma in trophic ulceration of a leprosy patient: a case study. ( 27169340 )
2016
22
An assessment of clinical pathways and missed opportunities for the diagnosis of nodular melanoma versus superficial spreading melanoma. ( 26563931 )
2016
23
Pigmented nodular melanoma: the predictive value of dermoscopic features using multivariate analysis. ( 25916655 )
2015
24
Cellular localization of CIP2A determines its prognostic impact in superficial spreading and nodular melanoma. ( 25663244 )
2015
25
RSK1 activation promotes invasion in nodular melanoma. ( 25579842 )
2015
26
Nodular melanoma serendipitously detected by airport full body scanners. ( 25501134 )
2015
27
Nodular Melanoma Arising in a Large Segmental Speckled Lentiginous Nevus. ( 25072686 )
2015
28
BRAF and NRAS mutations are heterogeneous and not mutually exclusive in nodular melanoma. ( 24710085 )
2015
29
Vaginal Amelanotic Nodular Malignant Melanoma in A Middle-Aged Female: A Rare Case Report and Review of Literature. ( 26085744 )
2015
30
Spontaneously regressing primary nodular melanoma of the glans penis. ( 25372268 )
2014
31
EGFR and cyclin D1 in nodular melanoma: correlation with pathohistological parameters and overall survival. ( 25304234 )
2014
32
Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology. ( 24855580 )
2014
33
Nodular melanoma on the hyponychium: clinical and dermoscopic features. ( 24765666 )
2014
34
Individual and ecological factors associated with early detection of nodular melanoma in the United States. ( 24500502 )
2014
35
Nodular malignant melanoma. Or maybe not? ( 24635092 )
2014
36
Dermoscopic evaluation of nodular melanoma. ( 23553375 )
2013
37
Nodular melanoma: a distinct clinical entity and the largest contributor to melanoma deaths in Victoria, Australia. ( 23182058 )
2013
38
An extensive primary nodular melanoma of the foot with associated distant metastases: a case report. ( 22560192 )
2012
39
Nodular melanoma arising in a patient treated with anti-tumor necrosis factor alpha antagonists. ( 22416995 )
2012
40
Prognostic importance of the mitotic marker phosphohistone H3 in cutaneous nodular melanoma. ( 22297638 )
2012
41
Superficial spreading and nodular melanoma are distinct biological entities: a challenge to the linear progression model. ( 22108608 )
2012
42
Nodular Melanoma Mimicking Keratoacanthoma: Lessons to learn. ( 22912931 )
2012
43
Late diagnosis of nodular melanoma of the foot in a 74-year-old Brazilian man. ( 22446655 )
2011
44
Blue-black rule: a simple dermoscopic clue to recognize pigmented nodular melanoma. ( 21916885 )
2011
45
Small nodular melanoma: the beginning of a life-threatening lesion. A clinical study on 11 cases. ( 21528661 )
2011
46
Unexpected detection of nodular melanoma of the skin on the scalp by I-123 IBZM brain SPECT. ( 21220985 )
2011
47
Key points in the dermoscopic diagnosis of hypomelanotic melanoma and nodular melanoma. ( 21175750 )
2011
48
Historical, clinical, and dermoscopic characteristics of thin nodular melanoma. ( 20231503 )
2010
49
"The malignant wart": a review of primary nodular melanoma of the foot and report of two cases. ( 20605563 )
2010
50
Pigmented poroid neoplasm mimicking nodular melanoma. ( 20536669 )
2010

Variations for Nodular Malignant Melanoma

Expression for Nodular Malignant Melanoma

Search GEO for disease gene expression data for Nodular Malignant Melanoma.

Pathways for Nodular Malignant Melanoma

Pathways related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.89 GNAQ HRAS NRAS
2 11.77 GNAQ HRAS NRAS
3
Show member pathways
11.75 GNAQ HRAS NRAS
4 11.66 GNAQ HRAS NRAS
5 11.6 GNAQ HRAS NRAS
6 11.55 GNAQ HRAS NRAS
7 11.28 GNAQ HRAS NRAS
8 11.27 HRAS NRAS
9 11.22 HRAS NRAS
10 11.11 HRAS NRAS
11 11.04 HRAS NRAS
12 11.03 HRAS NRAS
13
Show member pathways
11.01 HRAS NRAS
14
Show member pathways
10.95 HRAS NRAS
15 10.91 GNAQ HRAS NRAS
16 10.89 HRAS NRAS
17 10.85 HRAS NRAS
18 10.85 GNAQ HRAS NRAS
19 10.55 HRAS NRAS
20 10.1 GNAQ HRAS NRAS

GO Terms for Nodular Malignant Melanoma

Cellular components related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 8.92 EXT2 HRAS NRAS SEC23IP

Sources for Nodular Malignant Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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