Nodular Malignant Melanoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: NDL001 MIFTS: 35	Nodular Malignant Melanoma Categories: Cancer diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Nodular Malignant Melanoma

MalaCards integrated aliases for Nodular Malignant Melanoma:

Name: Nodular Malignant Melanoma ¹² ¹⁵

Nodular Melanoma ¹² ⁵⁴ ¹⁷ ⁷⁴

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:10047

NCIt ⁵¹ C4225

SNOMED-CT ⁶⁹ 2142002

EFO ¹⁷ EFO_0008515

UMLS ⁷⁴ C0334424

Sources

Summaries for Nodular Malignant Melanoma

Disease Ontology : ¹² A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule.

MalaCards based summary : Nodular Malignant Melanoma, also known as nodular melanoma, is related to melanoma and giant congenital nevus. An important gene associated with Nodular Malignant Melanoma is EXT2 (Exostosin Glycosyltransferase 2), and among its related pathways/superpathways are Long-term potentiation and Apelin signaling pathway. The drugs Ganciclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and brain.

Wikipedia : ⁷⁷ Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

Sources

Related Diseases for Nodular Malignant Melanoma

Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)

#	Related Disease	Score	Top Affiliating Genes
1	melanoma	10.5
2	giant congenital nevus	10.2	HRAS NRAS
3	benign struma ovarii	10.2	HRAS NRAS
4	schimmelpenning-feuerstein-mims syndrome	10.2	HRAS NRAS
5	ovarian melanoma	10.2	HRAS NRAS
6	marcus gunn phenomenon	10.1	HRAS NRAS
7	malignant struma ovarii	10.1	HRAS NRAS
8	fetal adenoma	10.1	HRAS NRAS
9	myelodysplastic myeloproliferative cancer	10.1	HRAS NRAS
10	melanocytic nevus syndrome, congenital	10.1	HRAS NRAS
11	acneiform dermatitis	10.1	HRAS NRAS
12	malignant skin fibrous histiocytoma	10.0	HRAS NRAS
13	mucosal melanoma	10.0	GNAQ NRAS
14	hidradenoma	10.0
15	spitz nevus	10.0
16	meningeal melanocytoma	10.0	GNAQ NRAS
17	core binding factor acute myeloid leukemia	10.0	HRAS NRAS
18	superficial spreading melanoma	10.0
19	vulvar melanoma	10.0	EXT2 HRAS NRAS
20	liver angiosarcoma	10.0	HRAS NRAS
21	conjunctival cancer	9.9	ABCB5 GNAQ NRAS
22	lentigines	9.9
23	melanoma in congenital melanocytic nevus	9.9
24	lentigo maligna melanoma	9.9
25	malignant dermis tumor	9.9	HRAS NRAS
26	malignant conjunctival melanoma	9.9	GNAQ HRAS NRAS
27	melanomatosis	9.9	GNAQ HRAS NRAS
28	nodular hidradenoma	9.9
29	eccrine acrospiroma	9.9
30	psoriasis	9.9
31	acrospiroma	9.9
32	hypoxia	9.9
33	meningeal melanomatosis	9.9	GNAQ HRAS NRAS
34	central nervous system melanocytic neoplasm	9.9	GNAQ HRAS NRAS
35	melanoma, cutaneous malignant 1	9.8	GNAQ HRAS NRAS
36	nevus, epidermal	9.8	HRAS NRAS
37	myeloma, multiple	9.8	DIS3 HRAS NRAS
38	retinoblastoma	9.8
39	leprosy 3	9.8
40	basal cell carcinoma 1	9.8
41	basal cell carcinoma	9.8
42	keratoacanthoma	9.8
43	pigmented basal cell carcinoma	9.8
44	acral lentiginous melanoma	9.8
45	skin melanoma	9.8
46	hansen's disease	9.8

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:

Sources

Symptoms & Phenotypes for Nodular Malignant Melanoma

Sources

Drugs & Therapeutics for Nodular Malignant Melanoma

Drugs for Nodular Malignant Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Ganciclovir

Approved, Investigational

Phase 1

82410-32-0

3454

Synonyms:

106931-35-5

107910-75-8 (mono-hydrochloride salt)

2-(6-amino-Purin-9-ylmethoxy)-propane-1,3-diol

2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol

2-Amino-1,9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6-H-purin-6-one

2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one

2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one

2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one

2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one

2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol

2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol

2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one

2-amino-9-(2-Hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one

2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one

2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone

2-amino-9-(2-Hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone

2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one

2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-3H-purin-6-one

2'-NDG

2'-Nor-2'-deoxyguanosine

82410-32-0

86357-12-2

9-((1,3-Dihydroxy-2-propoxy)methyl)guanine

9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine

9-(1,3-DIHYDROXY-propoxymethane)guanine

9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE

9-[(1,3-dihydroxy-2-propoxy)methyl]guanine

9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine

96551-29-0

AC-12604

AC1L1FZ2

AC1Q52OB

AKOS004119898

BB_NC-1042

BIDD:GT0783

Biolf 62

BIOLF-62

BPBio1_000877

BSPBio_000797

BW 759

BW 759U

BW-759U

BW-795

BW-B 759U

CAS-82410-32-0

CCRIS 9212

CHEBI:465284

CHEMBL182

CID3454

Citovirax

CPD000058324

Cymevan

Cymeven

Cymevene

Cytovene

Cytovene (TN)

Cytovene-IV

D00333

DB01004

DRG-0018

EU-0100539

G 2536

G2536_SIGMA

GA2

ganciclovir

Ganciclovir

Ganciclovir & C34-dgA immunotoxin

Ganciclovir & D5-dgA immunotoxin

Ganciclovir (JAN/USP/INN)

Ganciclovir [USAN:INN:BAN:JAN]

Ganciclovir sodium

GANCICLOVIR SODIUM

Ganciclovir, monosodium salt

Ganciclovirum

Ganciclovirum [Latin]

Gancyclovir

GCV & 1110U81

GCV & MSL

Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)- and MSL, neutralizing monoclonal antibody

HHEMG

HMS1570H19

HMS2090K08

HSDB 6512

Hydroxyacyclovir

I07-0010

IN1478

Lopac0_000539

Lopac-G-2536

LS-73939

MB3795

MLS000028481

MLS001077349

MolPort-000-758-398

MolPort-002-507-301

NCGC00015471-01

NCGC00015471-02

NCGC00015471-03

NCGC00015471-06

NCGC00093928-01

NCGC00093928-02

NCGC00168567-01

nchembio.87-comp3

PDSP1_000816

PDSP2_000803

Prestwick_1068

Prestwick0_000839

Prestwick1_000839

Prestwick2_000839

Prestwick3_000839

RS-21592

SAM002548936

SMP2_000038

SMR000058324

SPBio_002718

ST-605

STK801910

UNII-P9G3CKZ4P5

Virgan

Vitrasert

Vitrasert (TN)

ZINC00001505

Zirgan

Anti-Infective Agents

Phase 1

Antiviral Agents

Phase 1

Nucleic Acid Synthesis Inhibitors

Phase 1

Ganciclovir triphosphate

Phase 1

Tyrosine

Approved, Investigational, Nutraceutical

Not Applicable

60-18-4

6057

Synonyms:

(-)-a-amino-P-Hydroxyhydrocinnamate

(-)-a-amino-P-Hydroxyhydrocinnamic acid

(-)-alpha-amino-P-Hydroxyhydrocinnamate

(-)-alpha-amino-P-Hydroxyhydrocinnamic acid

(-)-alpha-Amino-p-hydroxyhydrocinnamic acid

(-)-α-amino-P-hydroxyhydrocinnamate

(−)-α-amino-p-hydroxyhydrocinnamic acid

(-)-α-amino-P-hydroxyhydrocinnamic acid

(2S)-2-amino-3-(4-Hydroxyphenyl)propanoate

(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid

(2S)-2-amino-3-(4-Hydroxyphenyl)propanoic acid

(S)-(-)-Tyrosine

(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid

(S)-2-amino-3-(P-Hydroxyphenyl)propionate

(S)-2-amino-3-(P-Hydroxyphenyl)propionic acid

(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid

(S)-3-(p-Hydroxyphenyl)alanine

(S)-3-(P-Hydroxyphenyl)alanine

(S)-a-amino-4-Hydroxybenzenepropanoate

(S)-a-amino-4-Hydroxy-benzenepropanoate

(S)-a-amino-4-Hydroxybenzenepropanoic acid

(S)-a-amino-4-Hydroxy-benzenepropanoic acid

(S)-alpha-amino-4-Hydroxybenzenepropanoate

(S)-alpha-amino-4-Hydroxy-benzenepropanoate

(S)-alpha-amino-4-Hydroxybenzenepropanoic acid

(S)-alpha-amino-4-Hydroxy-benzenepropanoic acid

(S)-alpha-Amino-4-hydroxybenzenepropanoic acid

(S)-Tyrosine

(S)-α-amino-4-hydroxybenzenepropanoate

(S)-α-amino-4-hydroxybenzenepropanoic acid

140-43-2

1991-85-1

25619-78-7

2-amino-3-(4-Hydroxyphen yl)-2-amino-3-(4-hydroxyphenyl)-propanoate

2-amino-3-(4-Hydroxyphen yl)-2-amino-3-(4-hydroxyphenyl)-propanoic acid

2-Amino-3-(p-hydroxyphenyl)propionic acid

2csm

3-(4-Hydroxyphenyl)-L-alanine

3-(p-Hydroxyphenyl)alanine

46209-14-7

4-hydroxy-L-phenylalanine

4-Hydroxy-L-phenylalanine

4ts1

55520-40-6

60-18-4

93829_FLUKA

93829_SIGMA

AB1002647

AC-11295

AC1L1LPI

AC1Q4U7L

AC1Q4U7M

AI3-09055

alpha-Amino-beta-(4-hydroxyphenyl)propionic acid

AR-1J3457

BB_NC-1194

Benzenepropanoate

Benzenepropanoic acid

beta-(p-Hydroxyphenyl)alanine

bmse000051

C00082

CHEBI:17895

CHEMBL925

CID6057

D00022

DB00135

DB03839

DD69927C-C6A8-4BC6-8E9A-0AB423B176E7

DTY

EINECS 200-460-4

FEMA No. 3736

Free-Form L-Tyrosine

HSDB 2003

H-Tyr-OH

L Tyrosine

L-(-)-Tyrosine

L-2-Amino-3-p-hydroxyphenylpropanoic acid

L-p-Tyrosine

L-P-Tyrosine

LS-2336

L-Tyrosin

L-tyrosine

L-Tyrosine (9CI)

L-Tyrosine (JAN)

L-Tyrosine hydrochloride

L-Tyrosine, homopolymer

L-Tyrosine, monomer

Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs

Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs, oxidized with hydrogen peroxide

Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs, oxidized with hydrogen peroxide, <3 kd fraction

Melanin synthesized from Tyr substrate catalyzed by tyrosinase, brominated with N-bromosuccinimide

Melanin synthesized from Tyr substrate catalyzed by tyrosinase, sulfonated using sulfur trioxide/DMF complex for 1.5-7 hours

MolPort-001-792-016

NCGC00159350-02

NCGC00159350-03

nchembio.105-comp1

nchembio.121-comp7

nchembio.186-comp84

nchembio.284-comp7

nchembio816-comp11

NSC 82624

Para tyrosine

Para-tyrosine

p-Tyrosine

P-Tyrosine

Rxosine

T0550

T3754_SIAL

T4321_SIAL

T4321_SIGMA

T8566_SIGMA

tirosina

Tirosina

Tirosina [Spanish]

tyr

Tyr

TYR NH3+ COOH

tyrosine

Tyrosine

TYROSINE

Tyrosine (USP/INN)

Tyrosine (VAN)

Tyrosine [USAN:INN]

Tyrosine Power

Tyrosine, L- (8CI)

Tyrosine, L isomer

Tyrosine, L-isomer

Tyrosinum

Tyrosinum [Latin]

UNII-42HK56048U

W373605_ALDRICH

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Dinaciclib in Treating Patients With Stage IV Melanoma	Active, not recruiting	NCT00937937	Phase 2	Dinaciclib
2	Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma	Terminated	NCT01120275	Phase 2	gamma-secretase/Notch signalling pathway inhibitor RO4929097
3	Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma	Completed	NCT00005057	Phase 1	ganciclovir
4	cKIT, BRAF/NRAS Mutations in Advanced Melanoma : Clinical Outcome in Response to Tyrosine-kinase Inhibitors - KitMel Project	Completed	NCT01543113	Not Applicable
5	Study of Families With Melanoma	Recruiting	NCT00445783

Search NIH Clinical Center for Nodular Malignant Melanoma

Sources

Genetic Tests for Nodular Malignant Melanoma

Sources

Anatomical Context for Nodular Malignant Melanoma

MalaCards organs/tissues related to Nodular Malignant Melanoma:

⁴²

Skin, Lymph Node, Brain, Myeloid

Sources

Publications for Nodular Malignant Melanoma

Articles related to Nodular Malignant Melanoma:

(show top 50) (show all 98)

#	Title	Authors	Year
1	Balloon Cell Primary Nodular Melanoma: Dermoscopy Evidence. ( 31106022 )	Seabra Resende FS...Di Meo N	2019
2	Nodular Melanoma in an African American Female. ( 31019646 )	Brown V...Laks J	2019
3	Matrical Carcinoma with Melanocytic Hyperplasia Mimicking Nodular Melanoma in an Elderly Mexican Male. ( 30785652 )	Lehmer L...de Feraudy S	2019
4	Comparison of five different scoring methods in the evaluation of inflammatory infiltration (tumor-infiltrating lymphocytes) in superficial spreading and nodular melanoma. ( 30506645 )	N?mejcov? K...Dundr P	2019
5	Comprehensive histopathological comparison of epidermotropic/dermal metastatic melanoma and primary nodular melanoma. ( 28881040 )	Skala SL...Chan MP	2018
6	Nodular Melanoma: A Histopathologic Entity? ( 29182796 )	Green AC...Marais R	2018
7	Desmoplastic transformation of a nodular melanoma arising from a speckled lentiginous nevus. ( 29464760 )	Miura K...Okazaki M	2018
8	Nodular melanoma presenting as an exophytic subungual mass. ( 29911502 )	Finlay B...Barrett K	2018
9	Complete amelanotic acral nodular melanoma. ( 30322988 )	Mei X...Wu Z	2018
10	Red nodular melanoma of the penile foreskin: A case report and literature review. ( 30233796 )	Maruyama Y...Nasu Y	2018
11	Improving the early diagnosis of early nodular melanoma: can we do better? ( 30079779 )	Corneli P...di Meo N	2018
12	Polypoid melanoma: an aggressive variant of nodular melanoma. ( 30063786 )	P?rez-Wilson J...Castro A	2018
13	Case of nodular melanoma on the upper eyelid dermoscopically mimicking pigmented basal cell carcinoma. ( 27649925 )	Asahara M...Saeki H	2017
14	Performance of the "if in doubt, cut it out" rule for the management of nodular melanoma. ( 29085713 )	Moscarella E...Argenziano G	2017
15	Nodular melanoma is less likely than superficial spreading melanoma to be histologically associated with a naevus. ( 29020904 )	Pan Y...Kelly JW	2017
16	Rare nodular malignant melanoma of the heel in the Caribbean: A case report. ( 28012339 )	Warner WA...Maharaj R	2017
17	Case report of nodular melanoma within congenital melanocytic nevus- primary closure challenge. ( 26826932 )	Eljuga D...Vrdoljak DV	2016
18	BRAF-V600E expression in primary nodular melanoma is associated with aggressive tumour features and reduced survival. ( 26924424 )	Hugdahl E...Akslen LA	2016
19	Nodular Melanoma. ( 26989291 )	Saaiq M...Siddiqui S	2016
20	Dermoscopy of Nodular Melanoma: Review of the Literature and Report of 3 Cases. ( 27663921 )	?or?evi? Brlek Z...Marinovi? B	2016
21	Nodular melanoma in trophic ulceration of a leprosy patient: a case study. ( 27169340 )	Zhu J...Liu Y	2016
22	An assessment of clinical pathways and missed opportunities for the diagnosis of nodular melanoma versus superficial spreading melanoma. ( 26563931 )	Cicchiello M...Kelly JW	2016
23	BRAF and NRAS mutations are heterogeneous and not mutually exclusive in nodular melanoma. ( 24710085 )	Chiappetta C...Di Cristofano C	2015
24	Nodular Melanoma Arising in a Large Segmental Speckled Lentiginous Nevus. ( 25072686 )	Gescheidt-Shoshany H...Bergman R	2015
25	Nodular melanoma serendipitously detected by airport full body scanners. ( 25501134 )	Mayer JE...Adams BB	2015
26	RSK1 activation promotes invasion in nodular melanoma. ( 25579842 )	Salhi A...Osman I	2015
27	Cellular localization of CIP2A determines its prognostic impact in superficial spreading and nodular melanoma. ( 25663244 )	Fl?renes VA...Slipicevic A	2015
28	Pigmented nodular melanoma: the predictive value of dermoscopic features using multivariate analysis. ( 25916655 )	Pizzichetta MA...Italian Melanoma Intergroup	2015
29	Vaginal Amelanotic Nodular Malignant Melanoma in A Middle-Aged Female: A Rare Case Report and Review of Literature. ( 26085744 )	Satyanarayan...Sharma N	2015
30	Individual and ecological factors associated with early detection of nodular melanoma in the United States. ( 24500502 )	Moreau JF...Ferris LK	2014
31	Nodular melanoma on the hyponychium: clinical and dermoscopic features. ( 24765666 )	Yamamoto S...Shimada S	2014
32	Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology. ( 24855580 )	Rosendahl C...Kittler H	2014
33	EGFR and cyclin D1 in nodular melanoma: correlation with pathohistological parameters and overall survival. ( 25304234 )	Katunari? M...Zamolo G	2014
34	Spontaneously regressing primary nodular melanoma of the glans penis. ( 25372268 )	Yang A...Cassarino DS	2014
35	Nodular malignant melanoma. Or maybe not? ( 24635092 )	Cabral R...Tellechea O	2014
36	Nodular melanoma: a distinct clinical entity and the largest contributor to melanoma deaths in Victoria, Australia. ( 23182058 )	Mar V...Kelly JW	2013
37	Dermoscopic evaluation of nodular melanoma. ( 23553375 )	Menzies SW...Kreusch J	2013
38	Nodular Melanoma Mimicking Keratoacanthoma: Lessons to learn. ( 22912931 )	Muthupalaniappen L...Ali SA	2012
39	Superficial spreading and nodular melanoma are distinct biological entities: a challenge to the linear progression model. ( 22108608 )	Greenwald HS...Osman I	2012
40	Prognostic importance of the mitotic marker phosphohistone H3 in cutaneous nodular melanoma. ( 22297638 )	Ladstein RG...Akslen LA	2012
41	Nodular melanoma arising in a patient treated with anti-tumor necrosis factor alpha antagonists. ( 22416995 )	Carlesimo M...Camplone G	2012
42	An extensive primary nodular melanoma of the foot with associated distant metastases: a case report. ( 22560192 )	Malone M...Boulton AJ	2012
43	Key points in the dermoscopic diagnosis of hypomelanotic melanoma and nodular melanoma. ( 21175750 )	Moloney FJ...Menzies SW	2011
44	Unexpected detection of nodular melanoma of the skin on the scalp by I-123 IBZM brain SPECT. ( 21220985 )	Booij J...van Amelsvoort T	2011
45	Small nodular melanoma: the beginning of a life-threatening lesion. A clinical study on 11 cases. ( 21528661 )	Bono A...Santinami M	2011
46	Blue-black rule: a simple dermoscopic clue to recognize pigmented nodular melanoma. ( 21916885 )	Argenziano G...Zalaudek I	2011
47	Late diagnosis of nodular melanoma of the foot in a 74-year-old Brazilian man. ( 22446655 )	Santos VM...Vasconcellos MJ	2011
48	Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. ( 21390477 )	Gatti A...Trevisan G	2010
49	Historical, clinical, and dermoscopic characteristics of thin nodular melanoma. ( 20231503 )	Kalkhoran S...Marghoob AA	2010
50	Nestin is expressed in HMB-45 negative melanoma cells in dermal parts of nodular melanoma. ( 20536663 )	Kanoh M...Katsuoka K	2010

Sources

Genes for Nodular Malignant Melanoma

Genes related to Nodular Malignant Melanoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	EXT2	Exostosin Glycosyltransferase 2	Protein Coding	16.17	DISEASES inferred ¹⁵
2	ZNF668	Zinc Finger Protein 668	Protein Coding	15.83	DISEASES inferred ¹⁵
3	ABCB5	ATP Binding Cassette Subfamily B Member 5	Protein Coding	15.7	DISEASES inferred ¹⁵
4	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	15.6	DISEASES inferred ¹⁵
5	SEC23IP	SEC23 Interacting Protein	Protein Coding	15.06	DISEASES inferred ¹⁵
6	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	14.82	DISEASES inferred ¹⁵
7	GNAQ	G Protein Subunit Alpha Q	Protein Coding	14.76	DISEASES inferred ¹⁵
8	NLRP1	NLR Family Pyrin Domain Containing 1	Protein Coding	14.62	DISEASES inferred ¹⁵
9	MTAP	Methylthioadenosine Phosphorylase	Protein Coding	14.62	DISEASES inferred ¹⁵
10	DIS3	DIS3 Homolog, Exosome Endoribonuclease And 3'-5' Exoribonuclease	Protein Coding	14.5	DISEASES inferred ¹⁵

Sources

Variations for Nodular Malignant Melanoma

Sources

Expression for Nodular Malignant Melanoma

Search GEO for disease gene expression data for Nodular Malignant Melanoma.

Sources

Pathways for Nodular Malignant Melanoma

Pathways related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show all 20)

#	Super pathways	Score	Top Affiliating Genes
1	Long-term potentiation ³⁸ Show member pathways Common Pathways Underlying Drug Addiction ¹ Dopamine D1-Like Receptor Family Signaling Pathways ⁶⁶	11.89	GNAQ HRAS NRAS
2	Apelin signaling pathway ³⁸	11.77	GNAQ HRAS NRAS
3	UVA-Induced MAPK Signaling ⁶⁵ Show member pathways UVB-Induced MAPK Signaling ⁶⁵	11.75	GNAQ HRAS NRAS
4	Sphingolipid signaling pathway ³⁸	11.66	GNAQ HRAS NRAS
5	Serotonergic synapse ³⁸	11.6	GNAQ HRAS NRAS
6	MAP Kinase Signaling ⁴	11.55	GNAQ HRAS NRAS
7	Gap junction ³⁸	11.28	GNAQ HRAS NRAS
8	Aryl Hydrocarbon Receptor ¹	11.27	HRAS NRAS
9	Vemurafenib Pathway, Pharmacodynamics ⁶²	11.22	HRAS NRAS
10	BDNF-TrkB Signaling ¹	11.11	HRAS NRAS
11	Extracellular vesicle-mediated signaling in recipient cells ¹	11.04	HRAS NRAS
12	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities ¹	11.03	HRAS NRAS
13	Bisphosphonate Pathway, Pharmacodynamics ⁶² Show member pathways RalA downstream regulated genes ¹	11.01	HRAS NRAS
14	EGFR Transactivation by Gastrin ⁶⁷ Show member pathways EGFR-dependent Endothelin signaling events ¹ SHC-related events triggered by IGF1R ⁶⁷	10.95	HRAS NRAS
15	Long-term depression ³⁸	10.91	GNAQ HRAS NRAS
16	MNAR-PELP1 and Estrogen Receptor Interaction ⁶⁵	10.89	HRAS NRAS
17	CD209 (DC-SIGN) signaling ⁶⁷	10.85	HRAS NRAS
18	Transcription_Transcription factor Tubby signaling pathways ²³	10.85	GNAQ HRAS NRAS
19	p38MAPK events ⁶⁷	10.55	HRAS NRAS
20	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling ¹	10.1	GNAQ HRAS NRAS

Sources

GO Terms for Nodular Malignant Melanoma

Cellular components related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi membrane	GO:0000139	8.92	EXT2 HRAS NRAS SEC23IP

Sources

Sources for Nodular Malignant Melanoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia