MCID: NDL005
MIFTS: 40

Nodular Medulloblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Nodular Medulloblastoma

MalaCards integrated aliases for Nodular Medulloblastoma:

Name: Nodular Medulloblastoma 12 15
Medulloblastoma, with Extensive Nodularity 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3873
NCIt 50 C5407
UMLS 73 C1334970

Summaries for Nodular Medulloblastoma

MalaCards based summary : Nodular Medulloblastoma, also known as medulloblastoma, with extensive nodularity, is related to medulloblastoma and atypical teratoid rhabdoid tumor, and has symptoms including vomiting, gait ataxia and headache. An important gene associated with Nodular Medulloblastoma is SUFU (SUFU Negative Regulator Of Hedgehog Signaling), and among its related pathways/superpathways are G-Beta Gamma Signaling and Pathways in cancer. Affiliated tissues include brain and thyroid, and related phenotypes are digestive/alimentary and growth/size/body region

Related Diseases for Nodular Medulloblastoma

Diseases related to Nodular Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 medulloblastoma 31.2 CTNNB1 GFAP GLI1 GLI2 PTCH1 SMARCB1
2 atypical teratoid rhabdoid tumor 29.5 CTNNB1 GFAP SMARCB1
3 pallister-hall syndrome 10.1 GLI1 GLI2
4 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.1 GLI1 GLI2
5 holoprosencephaly, recurrent infections, and monocytosis 10.1 GLI2 PTCH1
6 calcifying epithelial odontogenic tumor 10.1 GLI2 PTCH1
7 septopreoptic holoprosencephaly 10.1 GLI2 PTCH1
8 midline interhemispheric variant of holoprosencephaly 10.1 GLI2 PTCH1
9 alobar holoprosencephaly 10.1 GLI2 PTCH1
10 lobar holoprosencephaly 10.1 GLI2 PTCH1
11 chondroma 10.0 CTNNB1 GLI1
12 childhood medulloblastoma 10.0 PTCH1 SUFU
13 semilobar holoprosencephaly 10.0 GLI2 PTCH1
14 focal epithelial hyperplasia 10.0 GLI1 GLI2
15 greig cephalopolysyndactyly syndrome 10.0 GLI2 PTCH1
16 birt-hogg-dube syndrome 10.0 CTNNB1 PTCH1
17 obstructive hydrocephalus 10.0 GFAP SUFU
18 bardet-biedl syndrome 17 10.0 GLI2 PTCH1
19 pilomyxoid astrocytoma 10.0 GFAP SUFU
20 brachydactyly, type b1 10.0 CTNNB1 PTCH1
21 coffin-siris syndrome 1 10.0 GLI2 SMARCB1
22 melanotic medulloblastoma 10.0 GFAP SMARCB1
23 rhabdoid meningioma 10.0 GFAP SMARCB1
24 cerebral ventricle cancer 10.0 GFAP SMARCB1
25 pleomorphic xanthoastrocytoma 9.9 GFAP SMARCB1
26 tanycytic ependymoma 9.9 GFAP SMARCB1
27 choroid plexus cancer 9.9 GFAP SMARCB1
28 microform holoprosencephaly 9.9 GLI2 PTCH1 SUFU
29 cerebellopontine angle tumor 9.9 GFAP SMARCB1
30 medullomyoblastoma 9.9 GFAP SMARCB1
31 hemimegalencephaly 9.9 CTNNB1 GFAP
32 nervous system benign neoplasm 9.9 GFAP SMARCB1
33 keratocystic odontogenic tumor 9.9 GLI1 PTCH1 SUFU
34 ameloblastoma 9.9 GLI1 PTCH1
35 myoepithelioma 9.9 GFAP SMARCB1
36 ganglioglioma 9.9 GFAP SMARCB1
37 down syndrome 9.9
38 ectodermal dysplasia 9.9
39 rhabdoid cancer 9.9
40 neurilemmoma 9.9 GFAP SMARCB1
41 neuroma 9.9 GFAP SMARCB1
42 meningioma, familial 9.8 GFAP SMARCB1 SUFU
43 chordoma 9.8 GFAP SMARCB1
44 nervous system cancer 9.7 GFAP PTCH1 SMARCB1
45 basal cell nevus syndrome 9.7 GLI1 GLI2 PTCH1 SUFU
46 retinal detachment 9.7 CTNNB1 GFAP
47 cerebellar liponeurocytoma 9.6 GFAP PTCH1 SMARCB1 SUFU
48 adult medulloblastoma 9.6 GFAP GLI1 PTCH1 SUFU
49 basal cell carcinoma 9.6 CTNNB1 GLI1 GLI2 PTCH1 SUFU
50 central nervous system cancer 9.4 GFAP GLI1 PTCH1 SMARCB1 SUFU

Graphical network of the top 20 diseases related to Nodular Medulloblastoma:



Diseases related to Nodular Medulloblastoma

Symptoms & Phenotypes for Nodular Medulloblastoma

UMLS symptoms related to Nodular Medulloblastoma:


vomiting, gait ataxia, headache

MGI Mouse Phenotypes related to Nodular Medulloblastoma:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.07 CTNNB1 GFAP GLI1 GLI2 PTCH1 SMARCB1
2 growth/size/body region MP:0005378 10.04 CTNNB1 GFAP GLI1 GLI2 PTCH1 SMARCB1
3 behavior/neurological MP:0005386 10.03 CTNNB1 GFAP GLI1 GLI2 PTCH1 SMARCB1
4 cellular MP:0005384 10.02 CTNNB1 GFAP GLI1 GLI2 PTCH1 SMARCB1
5 mortality/aging MP:0010768 10 CTNNB1 GFAP GLI1 GLI2 PTCH1 SMARCB1
6 embryo MP:0005380 9.99 CTNNB1 GLI1 GLI2 PTCH1 SMARCB1 SUFU
7 craniofacial MP:0005382 9.93 CTNNB1 GLI1 GLI2 PTCH1 SUFU
8 nervous system MP:0003631 9.91 CTNNB1 GFAP GLI1 GLI2 PTCH1 SMARCB1
9 limbs/digits/tail MP:0005371 9.88 CTNNB1 GLI1 GLI2 PTCH1 SUFU
10 muscle MP:0005369 9.83 CTNNB1 GFAP GLI2 PTCH1 SMARCB1
11 neoplasm MP:0002006 9.8 CTNNB1 GLI1 PTCH1 SMARCB1 SUFU
12 normal MP:0002873 9.73 CTNNB1 GFAP GLI1 GLI2 PTCH1 SUFU
13 no phenotypic analysis MP:0003012 9.72 CTNNB1 GLI1 GLI2 PTCH1 SUFU
14 reproductive system MP:0005389 9.55 CTNNB1 GLI1 GLI2 PTCH1 SMARCB1
15 respiratory system MP:0005388 9.35 CTNNB1 GLI1 GLI2 PTCH1 SUFU
16 vision/eye MP:0005391 9.1 CTNNB1 GFAP GLI2 PTCH1 SMARCB1 SUFU

Drugs & Therapeutics for Nodular Medulloblastoma

Search Clinical Trials , NIH Clinical Center for Nodular Medulloblastoma

Genetic Tests for Nodular Medulloblastoma

Anatomical Context for Nodular Medulloblastoma

MalaCards organs/tissues related to Nodular Medulloblastoma:

41
Brain, Thyroid

Publications for Nodular Medulloblastoma

Articles related to Nodular Medulloblastoma:

# Title Authors Year
1
-Erratum for the paper "Kalogeraki A, Tamiolakis D, Mavrigiannaki P, Karvelaskalogerakis M, Datseri G, Agelaki S, Papadopoulos S. Recurrent Cerebellar Desmoplastic/Nodular Medulloblastoma in Cerebrospinal Fluid (CSF) in the Elderly. A Cytologic Diagnosis. Rom J Intern Med. 2016; 54(2):137-9". ( 28118148 )
2017
2
Desmoplastic Nodular Medulloblastoma in Young Children: A Management Dilemma. ( 29156007 )
2017
3
Recurrent Cerebellar Desmoplastic/Nodular Medulloblastoma in Cerebrospinal Fluid (CSF) in the Elderly. A Cytologic Diagnosis. ( 27352444 )
2016
4
Clinical, pathological, and molecular data on desmoplastic/nodular medulloblastoma: case studies and a review of the literature. ( 26857864 )
2016
5
SHH desmoplastic/nodular medulloblastoma and Gorlin syndrome in the setting of Down syndrome: case report, molecular profiling, and review of the literature. ( 27444290 )
2016
6
Ovarian primitive-type neuroectodermal tumour composed of desmoplastic/nodular medulloblastoma-like and atypical teratoid/rhabdoid tumour components. ( 26383534 )
2015
7
Cavernous angioma after chemotherapy for desmoplastic/nodular medulloblastoma associated with anhidrotic ectodermal dysplasia. ( 26231569 )
2015
8
High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age. ( 22508808 )
2012
9
Atypical teratoid rhabdoid tumor mimicking beta-catenin-positive nodular medulloblastoma. ( 21229255 )
2011
10
Nodular medulloblastoma. ( 11014561 )
2000

Variations for Nodular Medulloblastoma

Expression for Nodular Medulloblastoma

Search GEO for disease gene expression data for Nodular Medulloblastoma.

Pathways for Nodular Medulloblastoma

GO Terms for Nodular Medulloblastoma

Cellular components related to Nodular Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium GO:0005929 9.46 GLI1 GLI2 PTCH1 SUFU
2 ciliary tip GO:0097542 9.13 GLI1 GLI2 SUFU
3 ciliary base GO:0097546 8.8 GLI1 GLI2 SUFU

Biological processes related to Nodular Medulloblastoma according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.98 CTNNB1 GLI1 GLI2 SMARCB1
2 cell differentiation GO:0030154 9.97 CTNNB1 GLI1 GLI2 SMARCB1
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.95 CTNNB1 GLI2 PTCH1 SUFU
4 positive regulation of transcription, DNA-templated GO:0045893 9.92 CTNNB1 GLI1 GLI2 PTCH1
5 in utero embryonic development GO:0001701 9.8 CTNNB1 GLI2 PTCH1
6 skeletal system development GO:0001501 9.75 CTNNB1 GLI2 SUFU
7 lung development GO:0030324 9.71 CTNNB1 GLI1 GLI2
8 canonical Wnt signaling pathway GO:0060070 9.68 CTNNB1 GLI1
9 negative regulation of DNA-binding transcription factor activity GO:0043433 9.68 PTCH1 SUFU
10 pattern specification process GO:0007389 9.68 GLI2 PTCH1
11 embryonic digit morphogenesis GO:0042733 9.67 CTNNB1 GLI2
12 odontogenesis of dentin-containing tooth GO:0042475 9.67 CTNNB1 GLI2
13 negative regulation of osteoblast differentiation GO:0045668 9.66 PTCH1 SUFU
14 branching involved in ureteric bud morphogenesis GO:0001658 9.66 CTNNB1 PTCH1
15 skin development GO:0043588 9.65 CTNNB1 SUFU
16 liver regeneration GO:0097421 9.65 GLI1 PTCH1
17 smoothened signaling pathway GO:0007224 9.65 GLI1 GLI2 PTCH1
18 mammary gland development GO:0030879 9.64 GLI2 PTCH1
19 pituitary gland development GO:0021983 9.64 GLI1 GLI2
20 positive regulation of DNA replication GO:0045740 9.63 GLI1 GLI2
21 negative regulation of smoothened signaling pathway GO:0045879 9.62 PTCH1 SUFU
22 renal system development GO:0072001 9.61 CTNNB1 PTCH1
23 hindbrain development GO:0030902 9.61 CTNNB1 GLI2
24 spinal cord motor neuron differentiation GO:0021522 9.6 GLI2 PTCH1
25 cell fate determination GO:0001709 9.59 CTNNB1 PTCH1
26 negative regulation of chondrocyte differentiation GO:0032331 9.58 CTNNB1 GLI2
27 prostate gland development GO:0030850 9.57 GLI1 PTCH1
28 dorsal/ventral neural tube patterning GO:0021904 9.56 GLI2 PTCH1
29 regulation of osteoblast differentiation GO:0045667 9.55 CTNNB1 GLI1
30 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 9.52 GLI2 PTCH1
31 mammary gland duct morphogenesis GO:0060603 9.51 GLI2 PTCH1
32 spinal cord dorsal/ventral patterning GO:0021513 9.49 GLI2 SUFU
33 cerebellar cortex morphogenesis GO:0021696 9.46 GLI1 GLI2
34 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.43 GLI1 GLI2
35 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification GO:0021776 9.4 GLI2 SUFU
36 smoothened signaling pathway involved in ventral spinal cord interneuron specification GO:0021775 9.37 GLI2 SUFU
37 proximal/distal pattern formation GO:0009954 9.33 CTNNB1 GLI1 GLI2
38 ventral midline development GO:0007418 9.32 GLI1 GLI2
39 notochord regression GO:0060032 9.26 GLI1 GLI2
40 regulation of smoothened signaling pathway GO:0008589 9.13 GLI1 GLI2 PTCH1
41 dorsal/ventral pattern formation GO:0009953 8.92 CTNNB1 GLI1 GLI2 PTCH1

Molecular functions related to Nodular Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.13 CTNNB1 GLI1 GLI2
2 transcription factor binding GO:0008134 8.8 CTNNB1 GLI2 SUFU

Sources for Nodular Medulloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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