MCID: NDL005
MIFTS: 33

Nodular Medulloblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Nodular Medulloblastoma

MalaCards integrated aliases for Nodular Medulloblastoma:

Name: Nodular Medulloblastoma 12 15
Medulloblastoma, with Extensive Nodularity 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3873
NCIt 50 C5407
UMLS 73 C1334970

Summaries for Nodular Medulloblastoma

MalaCards based summary : Nodular Medulloblastoma, also known as medulloblastoma, with extensive nodularity, is related to atypical teratoid rhabdoid tumor and medulloblastoma, and has symptoms including headache, vomiting and gait ataxia. An important gene associated with Nodular Medulloblastoma is SUFU (SUFU Negative Regulator Of Hedgehog Signaling), and among its related pathways/superpathways are G-Beta Gamma Signaling and Pathways in cancer. Related phenotypes are digestive/alimentary and growth/size/body region

Related Diseases for Nodular Medulloblastoma

Diseases related to Nodular Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 atypical teratoid rhabdoid tumor 28.5 CTNNB1 GFAP SMARCB1
2 medulloblastoma 28.0 CTNNB1 GFAP GLI1 GLI2 PTCH1 SMARCB1
3 pallister-hall syndrome 10.2 GLI1 GLI2
4 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.2 GLI1 GLI2
5 split-hand/foot malformation 3 10.2 GLI1 SUFU
6 holoprosencephaly, recurrent infections, and monocytosis 10.2 GLI2 PTCH1
7 calcifying epithelial odontogenic tumor 10.2 GLI2 PTCH1
8 septopreoptic holoprosencephaly 10.2 GLI2 PTCH1
9 midline interhemispheric variant of holoprosencephaly 10.2 GLI2 PTCH1
10 alobar holoprosencephaly 10.2 GLI2 PTCH1
11 chondroma 10.1 CTNNB1 GLI1
12 lobar holoprosencephaly 10.1 GLI2 PTCH1
13 childhood medulloblastoma 10.1 PTCH1 SUFU
14 semilobar holoprosencephaly 10.0 GLI2 PTCH1
15 pilomyxoid astrocytoma 10.0 GFAP SUFU
16 bardet-biedl syndrome 17 10.0 GLI2 PTCH1
17 birt-hogg-dube syndrome 9.9 CTNNB1 PTCH1
18 melanotic medulloblastoma 9.9 GFAP SMARCB1
19 rhabdoid meningioma 9.9 GFAP SMARCB1
20 cerebral ventricle cancer 9.9 GFAP SMARCB1
21 cerebrum cancer 9.9 GFAP SMARCB1
22 supratentorial cancer 9.9 GFAP SMARCB1
23 organ system benign neoplasm 9.9 CTNNB1 SMARCB1
24 tanycytic ependymoma 9.8 GFAP SMARCB1
25 microform holoprosencephaly 9.8 GLI2 PTCH1 SUFU
26 pleomorphic xanthoastrocytoma 9.8 GFAP SMARCB1
27 choroid plexus cancer 9.8 GFAP SMARCB1
28 hemimegalencephaly 9.8 CTNNB1 GFAP
29 down syndrome 9.7
30 aging 9.7
31 ectodermal dysplasia 9.7
32 rhabdoid cancer 9.7
33 cerebellopontine angle tumor 9.7 GFAP SMARCB1
34 medullomyoblastoma 9.7 GFAP SMARCB1
35 keratocystic odontogenic tumor 9.7 GLI1 PTCH1 SUFU
36 myoepithelioma 9.6 GFAP SMARCB1
37 ganglioglioma 9.6 GFAP SMARCB1
38 integumentary system cancer 9.6 GLI1 GLI2 PTCH1
39 neurilemmoma 9.6 GFAP SMARCB1
40 ameloblastoma 9.5 GLI1 PTCH1
41 neuroma 9.4 GFAP SMARCB1
42 basal cell nevus syndrome 9.2 GLI1 GLI2 PTCH1 SUFU
43 nervous system cancer 9.1 GLI1 PTCH1 SMARCB1 SUFU
44 chordoma 9.1 GFAP SMARCB1
45 trehalase deficiency 9.0 CTNNB1 GLI2 PTCH1 SMARCB1
46 cerebellar liponeurocytoma 8.8 GFAP PTCH1 SMARCB1 SUFU
47 meningioma, familial 8.8 GFAP PTCH1 SMARCB1 SUFU
48 adult medulloblastoma 8.7 GFAP GLI1 PTCH1 SUFU
49 basal cell carcinoma 8.6 CTNNB1 GLI1 GLI2 PTCH1 SUFU
50 brain cancer 8.0 CTNNB1 GFAP GLI1 PTCH1 SMARCB1

Graphical network of the top 20 diseases related to Nodular Medulloblastoma:



Diseases related to Nodular Medulloblastoma

Symptoms & Phenotypes for Nodular Medulloblastoma

UMLS symptoms related to Nodular Medulloblastoma:


headache, vomiting, gait ataxia

MGI Mouse Phenotypes related to Nodular Medulloblastoma:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.07 CTNNB1 GLI2 GFAP GLI1 PTCH1 SMARCB1
2 growth/size/body region MP:0005378 10.04 GLI1 CTNNB1 GLI2 GFAP SUFU PTCH1
3 behavior/neurological MP:0005386 10.03 GLI1 CTNNB1 GLI2 GFAP PTCH1 SMARCB1
4 cellular MP:0005384 10.02 GLI1 CTNNB1 GLI2 GFAP PTCH1 SMARCB1
5 mortality/aging MP:0010768 10 GLI1 CTNNB1 GLI2 GFAP SUFU PTCH1
6 embryo MP:0005380 9.99 CTNNB1 GLI2 GLI1 PTCH1 SMARCB1 SUFU
7 craniofacial MP:0005382 9.93 GLI1 CTNNB1 GLI2 SUFU PTCH1
8 nervous system MP:0003631 9.91 GLI1 CTNNB1 GLI2 GFAP SUFU PTCH1
9 limbs/digits/tail MP:0005371 9.88 GLI1 CTNNB1 GLI2 SUFU PTCH1
10 muscle MP:0005369 9.83 CTNNB1 GLI2 GFAP PTCH1 SMARCB1
11 neoplasm MP:0002006 9.8 CTNNB1 GLI1 PTCH1 SMARCB1 SUFU
12 normal MP:0002873 9.73 GLI1 CTNNB1 GLI2 GFAP SUFU PTCH1
13 no phenotypic analysis MP:0003012 9.72 GLI1 CTNNB1 GLI2 SUFU PTCH1
14 reproductive system MP:0005389 9.55 GLI1 CTNNB1 GLI2 PTCH1 SMARCB1
15 respiratory system MP:0005388 9.35 GLI1 CTNNB1 GLI2 SUFU PTCH1
16 vision/eye MP:0005391 9.1 CTNNB1 GLI2 GFAP PTCH1 SMARCB1 SUFU

Drugs & Therapeutics for Nodular Medulloblastoma

Search Clinical Trials , NIH Clinical Center for Nodular Medulloblastoma

Genetic Tests for Nodular Medulloblastoma

Anatomical Context for Nodular Medulloblastoma

Publications for Nodular Medulloblastoma

Articles related to Nodular Medulloblastoma:

# Title Authors Year
1
-Erratum for the paper "Kalogeraki A, Tamiolakis D, Mavrigiannaki P, Karvelaskalogerakis M, Datseri G, Agelaki S, Papadopoulos S. Recurrent Cerebellar Desmoplastic/Nodular Medulloblastoma in Cerebrospinal Fluid (CSF) in the Elderly. A Cytologic Diagnosis. Rom J Intern Med. 2016; 54(2):137-9". ( 28118148 )
2017
2
Desmoplastic Nodular Medulloblastoma in Young Children: A Management Dilemma. ( 29156007 )
2017
3
Recurrent Cerebellar Desmoplastic/Nodular Medulloblastoma in Cerebrospinal Fluid (CSF) in the Elderly. A Cytologic Diagnosis. ( 27352444 )
2016
4
Clinical, pathological, and molecular data on desmoplastic/nodular medulloblastoma: case studies and a review of the literature. ( 26857864 )
2016
5
SHH desmoplastic/nodular medulloblastoma and Gorlin syndrome in the setting of Down syndrome: case report, molecular profiling, and review of the literature. ( 27444290 )
2016
6
Ovarian primitive-type neuroectodermal tumour composed of desmoplastic/nodular medulloblastoma-like and atypical teratoid/rhabdoid tumour components. ( 26383534 )
2015
7
Cavernous angioma after chemotherapy for desmoplastic/nodular medulloblastoma associated with anhidrotic ectodermal dysplasia. ( 26231569 )
2015
8
High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age. ( 22508808 )
2012
9
Atypical teratoid rhabdoid tumor mimicking beta-catenin-positive nodular medulloblastoma. ( 21229255 )
2011
10
Nodular medulloblastoma. ( 11014561 )
2000

Variations for Nodular Medulloblastoma

Expression for Nodular Medulloblastoma

Search GEO for disease gene expression data for Nodular Medulloblastoma.

Pathways for Nodular Medulloblastoma

GO Terms for Nodular Medulloblastoma

Cellular components related to Nodular Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium GO:0005929 9.46 GLI1 GLI2 PTCH1 SUFU
2 ciliary tip GO:0097542 9.13 GLI1 GLI2 SUFU
3 ciliary base GO:0097546 8.8 GLI1 GLI2 SUFU

Biological processes related to Nodular Medulloblastoma according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.99 CTNNB1 GLI1 GLI2 SMARCB1
2 cell differentiation GO:0030154 9.98 CTNNB1 GLI1 GLI2 SMARCB1
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.95 CTNNB1 GLI2 PTCH1 SUFU
4 positive regulation of transcription, DNA-templated GO:0045893 9.92 CTNNB1 GLI1 GLI2 PTCH1
5 in utero embryonic development GO:0001701 9.8 CTNNB1 GLI2 PTCH1
6 skeletal system development GO:0001501 9.75 CTNNB1 GLI2 SUFU
7 lung development GO:0030324 9.72 CTNNB1 GLI1 GLI2
8 smoothened signaling pathway GO:0007224 9.69 GLI1 GLI2 PTCH1
9 response to mechanical stimulus GO:0009612 9.68 GLI2 PTCH1
10 negative regulation of DNA binding transcription factor activity GO:0043433 9.68 PTCH1 SUFU
11 embryonic digit morphogenesis GO:0042733 9.67 CTNNB1 GLI2
12 odontogenesis of dentin-containing tooth GO:0042475 9.67 CTNNB1 GLI2
13 pattern specification process GO:0007389 9.67 GLI2 PTCH1
14 skin development GO:0043588 9.66 CTNNB1 SUFU
15 branching involved in ureteric bud morphogenesis GO:0001658 9.66 CTNNB1 PTCH1
16 negative regulation of osteoblast differentiation GO:0045668 9.65 PTCH1 SUFU
17 positive regulation of DNA replication GO:0045740 9.65 GLI1 GLI2
18 liver regeneration GO:0097421 9.64 GLI1 PTCH1
19 mammary gland development GO:0030879 9.64 GLI2 PTCH1
20 pituitary gland development GO:0021983 9.63 GLI1 GLI2
21 negative regulation of smoothened signaling pathway GO:0045879 9.62 PTCH1 SUFU
22 renal system development GO:0072001 9.61 CTNNB1 PTCH1
23 hindbrain development GO:0030902 9.61 CTNNB1 GLI2
24 spinal cord motor neuron differentiation GO:0021522 9.6 GLI2 PTCH1
25 cell fate determination GO:0001709 9.59 CTNNB1 PTCH1
26 negative regulation of chondrocyte differentiation GO:0032331 9.58 CTNNB1 GLI2
27 regulation of osteoblast differentiation GO:0045667 9.57 CTNNB1 GLI1
28 dorsal/ventral neural tube patterning GO:0021904 9.56 GLI2 PTCH1
29 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 9.54 GLI2 PTCH1
30 mammary gland duct morphogenesis GO:0060603 9.52 GLI2 PTCH1
31 spinal cord dorsal/ventral patterning GO:0021513 9.49 GLI2 SUFU
32 cerebellar cortex morphogenesis GO:0021696 9.48 GLI1 GLI2
33 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.46 GLI1 GLI2
34 smoothened signaling pathway involved in ventral spinal cord interneuron specification GO:0021775 9.43 GLI2 SUFU
35 proximal/distal pattern formation GO:0009954 9.43 CTNNB1 GLI1 GLI2
36 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification GO:0021776 9.4 GLI2 SUFU
37 ventral midline development GO:0007418 9.37 GLI1 GLI2
38 regulation of smoothened signaling pathway GO:0008589 9.33 GLI1 GLI2 PTCH1
39 notochord regression GO:0060032 9.32 GLI1 GLI2
40 prostate gland development GO:0030850 9.13 GLI1 GLI2 PTCH1
41 dorsal/ventral pattern formation GO:0009953 8.92 CTNNB1 GLI1 GLI2 PTCH1

Molecular functions related to Nodular Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.13 GLI1 GLI2 SMARCB1
2 transcription factor binding GO:0008134 8.8 CTNNB1 GLI2 SUFU

Sources for Nodular Medulloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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37 KEGG
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44 MeSH
45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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