MCID: NDL005
MIFTS: 41

Nodular Medulloblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Nodular Medulloblastoma

MalaCards integrated aliases for Nodular Medulloblastoma:

Name: Nodular Medulloblastoma 12 15
Medulloblastoma, with Extensive Nodularity 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3873
NCIt 50 C5407
SNOMED-CT 67 733902001
UMLS 70 C1334970

Summaries for Nodular Medulloblastoma

MalaCards based summary : Nodular Medulloblastoma, also known as medulloblastoma, with extensive nodularity, is related to rhabdoid cancer and medulloblastoma, and has symptoms including vomiting, headache and gait ataxia. An important gene associated with Nodular Medulloblastoma is SUFU (SUFU Negative Regulator Of Hedgehog Signaling), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. The drugs Methotrexate and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and skin, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Nodular Medulloblastoma

Diseases related to Nodular Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 rhabdoid cancer 29.1 SYP SMARCB1 SHH MYC
2 medulloblastoma 28.6 SYP SUFU SMARCB1 SHH PTCH2 PTCH1
3 atypical teratoid rhabdoid tumor 28.4 SYP SMARCB1 SHH MYCN MYC CTNNB1
4 basal cell carcinoma 27.9 SYP SUFU SHH PTCH2 PTCH1 MYCN
5 basal cell nevus syndrome 27.2 SUFU SMARCB1 SHH PTCH2 PTCH1 OTX2
6 ovary leiomyosarcoma 10.3 SUFU PTCH1
7 basal cell carcinoma, infundibulocystic 10.3 SUFU PTCH1
8 holoprosencephaly 1 10.3 SHH GLI2
9 polydactyly, preaxial ii 10.3 SHH PTCH1
10 holoprosencephaly, recurrent infections, and monocytosis 10.3 PTCH1 GLI2
11 calcifying epithelial odontogenic tumor 10.3 PTCH1 GLI2
12 combined pituitary hormone deficiencies, genetic forms 10.2 OTX2 GLI2
13 internal auditory canal lipoma 10.2 SMARCB1 PTCH1
14 holoprosencephaly 2 10.2 SHH GLI2
15 brain stem medulloblastoma 10.2 SHH CTNNB1
16 meningioma, radiation-induced 10.2 SUFU SMARCB1
17 culler-jones syndrome 10.2 SHH GLI2
18 hemimelia 10.2 GLI2 GLI1
19 desmoplastic infantile ganglioglioma 10.2 SYP MYCN
20 diabetes mellitus, neonatal, with congenital hypothyroidism 10.2 SUFU SHH
21 extracranial neuroblastoma 10.2 SYP MYCN
22 cervical neuroblastoma 10.2 SYP MYCN
23 adrenal neuroblastoma 10.1 SYP MYCN
24 midline interhemispheric variant of holoprosencephaly 10.1 SHH PTCH1 GLI2
25 prostate neuroendocrine neoplasm 10.1 SYP MYCN
26 septopreoptic holoprosencephaly 10.1 SHH PTCH1 GLI2
27 holoprosencephaly 9 10.1 SHH PTCH1 GLI2
28 alobar holoprosencephaly 10.1 SHH PTCH1 GLI2
29 cystic basal cell carcinoma 10.1 SYP PTCH1
30 lobar holoprosencephaly 10.1 SHH PTCH1 GLI2
31 holoprosencephaly 11 10.1 SHH PTCH1 GLI2
32 holoprosencephaly 5 10.1 SHH PTCH1 GLI2
33 adamantinous craniopharyngioma 10.1 SHH CTNNB1
34 holoprosencephaly 7 10.1 SHH PTCH1 GLI2
35 solitary median maxillary central incisor 10.1 SHH PTCH1 GLI2
36 colobomatous microphthalmia 10.1 SHH PTCH1 OTX2
37 semilobar holoprosencephaly 10.1 SHH PTCH1 GLI2
38 acrocallosal syndrome 10.1 SUFU SHH GLI1
39 holoprosencephaly 3 10.1 SHH GLI2
40 esophageal atresia 10.1 SHH MYCN GLI2
41 optic nerve astrocytoma 10.1 SYP SMARCB1
42 brachydactyly, type a1 10.1 SHH PTCH1 GLI1
43 congenital nervous system abnormality 10.1 SHH PTCH1 GLI2
44 tumoral calcinosis, hyperphosphatemic, familial, 1 10.1 SHH PTCH1 GLI1
45 pineal region teratoma 10.1 SYP SMARCB1
46 septooptic dysplasia 10.1 SHH OTX2 GLI2
47 kidney rhabdoid cancer 10.1 SYP SMARCB1
48 basal cell carcinoma 1 10.1 PTCH2 PTCH1
49 hypopituitarism 10.1 SHH OTX2 GLI2
50 autonomic nervous system benign neoplasm 10.1 SYP MYCN

Graphical network of the top 20 diseases related to Nodular Medulloblastoma:



Diseases related to Nodular Medulloblastoma

Symptoms & Phenotypes for Nodular Medulloblastoma

UMLS symptoms related to Nodular Medulloblastoma:


vomiting; headache; gait ataxia

GenomeRNAi Phenotypes related to Nodular Medulloblastoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 10.25 PTCH2
2 Decreased viability GR00221-A-1 10.25 GLI2 MYC PTCH2 SMARCB1
3 Decreased viability GR00221-A-2 10.25 GLI2 PTCH2 SMARCB1
4 Decreased viability GR00221-A-3 10.25 MYC PTCH2 SMARCB1 SHH
5 Decreased viability GR00221-A-4 10.25 PTCH2
6 Decreased viability GR00249-S 10.25 MYC PTCH2 SMARCB1 SHH
7 Decreased viability GR00301-A 10.25 PTCH2
8 Decreased viability GR00381-A-1 10.25 SMARCB1
9 Decreased viability GR00386-A-1 10.25 GLI2 PTCH2
10 Decreased viability GR00402-S-2 10.25 MYC
11 shRNA abundance <= 50% GR00343-S 9.1 GLI2 OTX2 PTCH2 SHH SMARCB1 SUFU

MGI Mouse Phenotypes related to Nodular Medulloblastoma:

46 (show all 26)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.37 CTNNB1 GLI1 GLI2 MYC MYCN OTX2
2 digestive/alimentary MP:0005381 10.35 CTNNB1 GLI1 GLI2 MYC MYCN OTX2
3 growth/size/body region MP:0005378 10.32 CTNNB1 GLI1 GLI2 MYC MYCN OTX2
4 embryo MP:0005380 10.3 CTNNB1 GLI1 GLI2 MYC MYCN OTX2
5 cardiovascular system MP:0005385 10.28 CTNNB1 MYC MYCN OTX2 PTCH1 PTCH2
6 cellular MP:0005384 10.27 CTNNB1 GLI1 GLI2 MYC MYCN OTX2
7 homeostasis/metabolism MP:0005376 10.27 CTNNB1 GLI2 MYC MYCN OTX2 PTCH1
8 craniofacial MP:0005382 10.26 CTNNB1 GLI1 GLI2 MYC MYCN OTX2
9 nervous system MP:0003631 10.26 CTNNB1 GLI1 GLI2 MYC MYCN OTX2
10 mortality/aging MP:0010768 10.22 CTNNB1 GLI1 GLI2 MYC MYCN OTX2
11 normal MP:0002873 10.17 CTNNB1 GLI1 GLI2 MYC MYCN OTX2
12 integument MP:0010771 10.16 CTNNB1 GLI2 MYC PTCH1 PTCH2 SHH
13 muscle MP:0005369 10.16 CTNNB1 GLI2 MYC MYCN OTX2 PTCH1
14 limbs/digits/tail MP:0005371 10.15 CTNNB1 GLI1 GLI2 MYC MYCN PTCH1
15 endocrine/exocrine gland MP:0005379 10.14 CTNNB1 GLI1 GLI2 MYC OTX2 PTCH1
16 neoplasm MP:0002006 10.1 CTNNB1 GLI1 MYC PTCH1 PTCH2 SHH
17 no phenotypic analysis MP:0003012 10.06 CTNNB1 GLI1 GLI2 MYC MYCN PTCH1
18 hearing/vestibular/ear MP:0005377 10.05 CTNNB1 GLI2 MYC OTX2 PTCH1 SHH
19 reproductive system MP:0005389 10.02 CTNNB1 GLI1 GLI2 MYC MYCN OTX2
20 liver/biliary system MP:0005370 10.01 CTNNB1 MYC MYCN SHH SMARCB1 SUFU
21 respiratory system MP:0005388 9.86 CTNNB1 GLI1 GLI2 MYCN OTX2 PTCH1
22 renal/urinary system MP:0005367 9.85 CTNNB1 GLI1 MYCN PTCH1 PTCH2 SHH
23 skeleton MP:0005390 9.81 CTNNB1 GLI2 MYC MYCN OTX2 PTCH1
24 pigmentation MP:0001186 9.8 CTNNB1 MYC OTX2 PTCH1 SUFU
25 taste/olfaction MP:0005394 9.26 CTNNB1 OTX2 PTCH1 SHH
26 vision/eye MP:0005391 9.23 CTNNB1 GLI2 MYCN OTX2 PTCH1 SHH

Drugs & Therapeutics for Nodular Medulloblastoma

Drugs for Nodular Medulloblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
2
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
3
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
4
Etoposide Approved Phase 2 33419-42-0 36462
5
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
6
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
7
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
8 Tubulin Modulators Phase 2
9 Folic Acid Antagonists Phase 2
10 Antirheumatic Agents Phase 2
11 Vitamin B9 Phase 2
12 Immunosuppressive Agents Phase 2
13 Antimitotic Agents Phase 2
14 Vitamin B Complex Phase 2
15 Folate Phase 2
16 Alkylating Agents Phase 2
17 Etoposide phosphate Phase 2
18 Antimetabolites Phase 2
19 Immunologic Factors Phase 2
20 Dermatologic Agents Phase 2
21 Keratolytic Agents Phase 2
22 Podophyllotoxin Phase 2 518-28-5

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study for the Treatment of Non-metastatic Nodular Desmoplastic Medulloblastoma in Children Less Than 4 Years of Age Active, not recruiting NCT02017964 Phase 2 Carboplatin;Cyclophosphamide;Etoposide;Methotrexate;Vincristine Sulfate

Search NIH Clinical Center for Nodular Medulloblastoma

Genetic Tests for Nodular Medulloblastoma

Anatomical Context for Nodular Medulloblastoma

MalaCards organs/tissues related to Nodular Medulloblastoma:

40
Brain, Thyroid, Skin, Pineal, Cerebellum, Skeletal Muscle, Kidney

Publications for Nodular Medulloblastoma

Articles related to Nodular Medulloblastoma:

(show top 50) (show all 64)
# Title Authors PMID Year
1
An intrathecal limited postoperative chemotherapy regimen for the treatment of young children with nodular/desmoplastic medulloblastoma and medulloblastoma with extensive nodularity. 61
33689104 2021
2
[Medulloblastoma. Pathology]. 61
29703584 2021
3
Differentiation of Outcomes by Treatment Regimen and Histology in Central Nervous System Primary Embryonal Tumors. 61
32434022 2020
4
A Retrospective Analysis of the Demographics, Treatment, and Survival Outcomes of Patients with Desmoplastic Nodular Medulloblastoma Using the Surveillance, Epidemiology, and End Results (SEER) Database. 61
32782862 2020
5
Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort. 61
32330099 2020
6
Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker. 61
31781912 2020
7
Phase II Study of Nonmetastatic Desmoplastic Medulloblastoma in Children Younger Than 4 Years of Age: A Report of the Children's Oncology Group (ACNS1221). 61
31774708 2020
8
Childhood Medulloblastoma Revisited. 61
30516696 2018
9
Congenital medulloblastoma: Fetal and postnatal longitudinal observation with quantitative MRI. 61
30096555 2018
10
Central Nervous System-type Neuroepithelial Tumors and Tumor-like Proliferations Developing in the Gynecologic Tract and Pelvis: Clinicopathologic Analysis of 23 Cases. 61
30074494 2018
11
Medulloblastoma with extensive nodularity: A rare variant with a favorable outcome. 61
30233042 2018
12
Molecular characterization of medulloblastomas with extensive nodularity (MBEN). 61
29569031 2018
13
Desmoplastic nodular medulloblastoma in young children: a management dilemma. 61
29156007 2018
14
Concurrent IDH1 and SMARCB1 Mutations in Pediatric Medulloblastoma: A Case Report. 61
29971034 2018
15
-Erratum for the paper "Kalogeraki A, Tamiolakis D, Mavrigiannaki P, Karvelaskalogerakis M, Datseri G, Agelaki S, Papadopoulos S. Recurrent Cerebellar Desmoplastic/Nodular Medulloblastoma in Cerebrospinal Fluid (CSF) in the Elderly. A Cytologic Diagnosis. Rom J Intern Med. 2016; 54(2):137-9". 61
28118148 2017
16
Medulloblastoma With Extensive Nodularity: Tailored Therapy in a Low-resource Setting. 61
28267079 2017
17
Cerebellopontine angle medulloblastoma with extensive nodularity in a child: case report and review of the literature. 61
28013334 2017
18
Medulloblastoma with extensive nodularity: a tumour exclusively of infancy? 61
26990710 2017
19
Medulloblastoma with extensive nodularity (SHH medulloblastoma). 61
29517209 2017
20
SHH desmoplastic/nodular medulloblastoma and Gorlin syndrome in the setting of Down syndrome: case report, molecular profiling, and review of the literature. 61
27444290 2016
21
Medulloblastoma. 61
26336203 2016
22
Deciphering the real incidence of medulloblastoma with extensive nodularity in adult patients. 61
27412001 2016
23
Ovarian primitive-type neuroectodermal tumour composed of desmoplastic/nodular medulloblastoma-like and atypical teratoid/rhabdoid tumour components. 61
26383534 2016
24
Clinical, pathological, and molecular data on desmoplastic/nodular medulloblastoma: case studies and a review of the literature. 61
26857864 2016
25
Recurrent Cerebellar Desmoplastic/Nodular Medulloblastoma in Cerebrospinal Fluid (CSF) in the Elderly. A Cytologic Diagnosis. 61
27352444 2016
26
Paediatric Medulloblastoma: An Updated Review. 61
28358445 2016
27
Cavernous angioma after chemotherapy for desmoplastic/nodular medulloblastoma associated with anhidrotic ectodermal dysplasia. 61
26231569 2016
28
[Identification of a Family with SUFU Germline Deletion Based on a Case of Desmoplastic Medulloblastoma in an Infant]. 61
26691947 2016
29
Medulloblastoma treatment in a child on dialysis. 61
25054898 2014
30
Medulloblastoma in China: clinicopathologic analyses of SHH, WNT, and non-SHH/WNT molecular subgroups reveal different therapeutic responses to adjuvant chemotherapy. 61
24932704 2014
31
Atypical teratoid rhabdoid tumor in childhood, 15 cases of a single institute experience. 61
24448710 2014
32
Expression of heat shock proteins in medulloblastoma. 61
23992239 2013
33
Distinctive MRI features of pediatric medulloblastoma subtypes. 61
23521467 2013
34
[Characteristics of medulloblastoma in children under age of three years]. 61
23659115 2013
35
[Clinicopathologic significance of β-catenin protein and loss of heterozygosity on 10q in medulloblastoma]. 61
23324231 2012
36
Childhood medulloblastoma: the paradigm shift in molecular stratification and treatment profile. 61
22826514 2012
37
Infant brain tumors: a neuropathologic population-based institutional reappraisal. 61
22497851 2012
38
Medulloblastoma. 61
22622599 2012
39
High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age. 61
22508808 2012
40
Cytotoxic effects of chemotherapeutic drugs and heterocyclic compounds at application on the cells of primary culture of neuroepithelium tumors. 61
22420547 2012
41
Medulloblastoma with excessive nodularity: radiographic features and pathologic correlate. 61
23133782 2012
42
Magnetic resonance imaging spectrum of medulloblastoma. 61
21279509 2011
43
Atypical teratoid rhabdoid tumor mimicking beta-catenin-positive nodular medulloblastoma. 61
21229255 2011
44
Favourable prognosis in medulloblastoma with extensive nodularity is associated with mitogen-activated protein kinase upregulation. 61
22212915 2011
45
Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis. 61
20940197 2010
46
[The role of diagnostic neuropathology in familial tumour syndromes]. 61
20848106 2010
47
Medulloblastoma with extensive nodularity undergoing post-therapeutic maturation to a gangliocytoma: a case report and literature review. 61
21389751 2010
48
Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: results of the first UKCCSG/SIOP CNS 9204 trial. 61
19818598 2010
49
[WHO classification of tumours of the CNS: revised edition of 2007 with critical comments on the typing und grading of common-type diffuse gliomas]. 61
18820922 2008
50
Pathological and molecular heterogeneity of medulloblastoma. 61
18841049 2008

Variations for Nodular Medulloblastoma

Expression for Nodular Medulloblastoma

Search GEO for disease gene expression data for Nodular Medulloblastoma.

Pathways for Nodular Medulloblastoma

Pathways related to Nodular Medulloblastoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1 12.7 SUFU SHH PTCH2 PTCH1 MYC GLI2
2
Show member pathways
12.54 SMARCB1 SHH MYC CTNNB1
3
Show member pathways
12.49 SUFU PTCH2 PTCH1 GLI1
4
Show member pathways
12.42 PTCH2 PTCH1 GLI2 GLI1
5
Show member pathways
12.41 SUFU SHH PTCH1 GLI2 GLI1
6
Show member pathways
12.12 SUFU SHH PTCH2 PTCH1 GLI2 GLI1
7 12.11 SHH PTCH1 MYC CTNNB1
8 11.96 MYC GLI2 CTNNB1
9 11.96 SUFU SHH PTCH2 PTCH1 GLI2 GLI1
10 11.9 SHH MYC CTNNB1
11 11.85 SHH OTX2 MYC
12 11.36 SUFU SHH PTCH1 GLI2 GLI1
13 11.35 SHH PTCH1 GLI2 GLI1
14
Show member pathways
11.25 SHH PTCH2 PTCH1 GLI2
15 11.18 SHH OTX2 GLI2 GLI1
16 11.18 SUFU SHH PTCH2 PTCH1 GLI2 GLI1
17
Show member pathways
10.93 OTX2 MYC
18 10.43 SHH PTCH1
19
Show member pathways
10.38 SUFU SHH PTCH2 PTCH1 GLI2 GLI1
20 10.21 MYCN MYC

GO Terms for Nodular Medulloblastoma

Cellular components related to Nodular Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium GO:0005929 9.46 SUFU PTCH1 GLI2 GLI1
2 ciliary tip GO:0097542 9.13 SUFU GLI2 GLI1
3 ciliary base GO:0097546 8.8 SUFU GLI2 GLI1

Biological processes related to Nodular Medulloblastoma according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 10.21 SMARCB1 OTX2 MYCN MYC GLI2 GLI1
2 negative regulation of transcription by RNA polymerase II GO:0000122 10.12 SUFU SHH PTCH1 MYC GLI2 CTNNB1
3 positive regulation of transcription by RNA polymerase II GO:0045944 10.08 SMARCB1 SHH OTX2 MYCN MYC GLI2
4 positive regulation of cell proliferation GO:0008284 10.07 SHH MYC GLI2 GLI1 CTNNB1
5 negative regulation of apoptotic process GO:0043066 10.05 SHH MYC GLI2 CTNNB1
6 positive regulation of gene expression GO:0010628 10.03 SHH MYCN MYC CTNNB1
7 skeletal system development GO:0001501 9.9 SUFU GLI2 CTNNB1
8 kidney development GO:0001822 9.89 SHH GLI2 CTNNB1
9 forebrain development GO:0030900 9.86 SHH OTX2 CTNNB1
10 canonical Wnt signaling pathway GO:0060070 9.86 SHH GLI1 CTNNB1
11 lung development GO:0030324 9.85 SHH GLI2 GLI1 CTNNB1
12 odontogenesis of dentin-containing tooth GO:0042475 9.84 SHH GLI2 CTNNB1
13 pattern specification process GO:0007389 9.84 SHH PTCH1 GLI2
14 embryonic digit morphogenesis GO:0042733 9.83 SHH GLI2 CTNNB1
15 embryonic organ development GO:0048568 9.79 SHH PTCH1 CTNNB1
16 midbrain development GO:0030901 9.78 SHH OTX2 CTNNB1
17 hair follicle morphogenesis GO:0031069 9.77 SHH GLI2 CTNNB1
18 proximal/distal pattern formation GO:0009954 9.76 GLI2 GLI1 CTNNB1
19 skin development GO:0043588 9.76 SUFU SHH PTCH2 CTNNB1
20 positive regulation of transcription, DNA-templated GO:0045893 9.76 SHH PTCH1 OTX2 MYCN MYC GLI2
21 regulation of smoothened signaling pathway GO:0008589 9.75 PTCH1 OTX2 GLI1
22 beta-catenin-TCF complex assembly GO:1904837 9.74 MYC CTNNB1
23 positive regulation of DNA replication GO:0045740 9.74 GLI2 GLI1
24 pituitary gland development GO:0021983 9.74 GLI2 GLI1
25 embryonic hindlimb morphogenesis GO:0035116 9.74 SHH CTNNB1
26 pancreas development GO:0031016 9.74 SHH CTNNB1
27 branching morphogenesis of an epithelial tube GO:0048754 9.74 SHH GLI2
28 developmental growth GO:0048589 9.74 SHH GLI2
29 positive regulation of mesenchymal cell proliferation GO:0002053 9.74 SHH MYC CTNNB1
30 vasculature development GO:0001944 9.73 SHH CTNNB1
31 dopaminergic neuron differentiation GO:0071542 9.73 SHH OTX2
32 positive regulation of neuroblast proliferation GO:0002052 9.73 SHH CTNNB1
33 negative regulation of chondrocyte differentiation GO:0032331 9.73 GLI2 CTNNB1
34 spinal cord motor neuron differentiation GO:0021522 9.73 SHH PTCH1 GLI2
35 branching involved in ureteric bud morphogenesis GO:0001658 9.73 SHH PTCH1 MYC CTNNB1
36 epithelial tube branching involved in lung morphogenesis GO:0060441 9.72 SHH CTNNB1
37 anatomical structure formation involved in morphogenesis GO:0048646 9.72 SHH GLI2
38 male genitalia development GO:0030539 9.72 SHH CTNNB1
39 osteoblast development GO:0002076 9.72 SHH GLI2
40 somite development GO:0061053 9.71 SHH PTCH1
41 regulation of osteoblast differentiation GO:0045667 9.71 GLI1 CTNNB1
42 digestive tract morphogenesis GO:0048546 9.71 SHH GLI1
43 ectoderm development GO:0007398 9.71 SHH CTNNB1
44 smooth muscle tissue development GO:0048745 9.71 SHH PTCH1
45 hindbrain development GO:0030902 9.71 SHH GLI2 CTNNB1
46 metanephric collecting duct development GO:0072205 9.7 SHH PTCH1
47 positive regulation of T cell differentiation in thymus GO:0033089 9.7 SHH GLI2
48 negative regulation of cell division GO:0051782 9.7 PTCH1 MYC
49 positive regulation of skeletal muscle tissue development GO:0048643 9.7 SHH CTNNB1
50 cell fate determination GO:0001709 9.7 PTCH2 PTCH1 CTNNB1

Molecular functions related to Nodular Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.67 OTX2 MYCN MYC GLI2
2 transcription factor binding GO:0008134 9.62 SUFU MYC GLI2 CTNNB1
3 patched binding GO:0005113 9.26 SHH PTCH1
4 hedgehog family protein binding GO:0097108 9.16 PTCH2 PTCH1
5 hedgehog receptor activity GO:0008158 8.96 PTCH2 PTCH1
6 smoothened binding GO:0005119 8.62 PTCH2 PTCH1

Sources for Nodular Medulloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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