Nodular Nonsuppurative Panniculitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Nodular Nonsuppurative Panniculitis

MalaCards integrated aliases for Nodular Nonsuppurative Panniculitis:

Name: Nodular Nonsuppurative Panniculitis ¹¹ ¹⁹ ¹⁴ ¹⁶ ⁷⁵

Relapsing Febrile Nodular Nonsuppurative Panniculitis ¹¹ ¹⁹ ⁵⁸

Weber-Christian Disease ¹¹ ⁵⁸ ⁷⁵

Panniculitis, Nodular Nonsuppurative ⁴³ ⁷¹

Pfeiffer-Weber-Christian Syndrome ¹⁹ ⁵⁸

Idiopathic Nodular Panniculitis ¹⁹ ⁵⁸

Weber-Christian Panniculitis ¹⁹ ⁵⁸

Nodular Non-Suppurative Febrile Panniculitis ¹¹

Relapsing Febrile Nodular Panniculitis ⁵⁸

Nodular Non-Suppurative Panniculitis ⁵⁸

Panniculitis Nodular Nonsuppurative ¹⁹

Idiopathic Lobular Panniculitis ⁵⁸

Weber - Christian Disease ¹¹

Wcd ⁵⁸

Characteristics:

Age Of Onset:

Nodular Non-Suppurative Panniculitis: Adult ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³¹ ³²

Diseases of the musculoskeletal system and connective tissue

Systemic connective tissue disorders

Other systemic involvement of connective tissue

Relapsing panniculitis [Weber-Christian]

Orphanet: ⁵⁸

Rare skin diseases

External Ids:

Disease Ontology ¹¹ DOID:1525

MeSH ⁴³ D010201

SNOMED-CT ⁶⁸ 203120002

ICD10 ³¹ M35.6

MESH via Orphanet ⁴⁴ D010201

ICD10 via Orphanet ³² M35.6

UMLS via Orphanet ⁷² C0030328

Orphanet ⁵⁸ ORPHA33577

EFO ¹⁶ EFO_1000742

UMLS ⁷¹ C0030328

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Summaries for Nodular Nonsuppurative Panniculitis

GARD: ¹⁹ Nodular nonsuppurative panniculitis describes a rare group of skin disorders characterized by tender, painful bumps below the surface of the skin (subcutaneous nodules) that usually lead to inflammation of the subcutaneous layer of fat (panniculitis). These nodules tend to be 1-2 centimeters in length and most often affect the legs and feet. In most people, this condition is associated with fever, a general feeling of ill health (malaise), muscle pain, and/or abdominal pain. The exact cause of Nodular nonsuppurative panniculitis is unknown.

MalaCards based summary: Nodular Nonsuppurative Panniculitis, also known as relapsing febrile nodular nonsuppurative panniculitis, is related to panniculitis and non-alcoholic fatty liver disease. An important gene associated with Nodular Nonsuppurative Panniculitis is SERPINA1 (Serpin Family A Member 1), and among its related pathways/superpathways is Development_Leptin signaling via JAK/STAT and MAPK cascades. Affiliated tissues include skin, eye and pancreas, and related phenotypes are nausea and vomiting and fever

Orphanet: ⁵⁸ A rare skin disorder characterized by recurring inflammation in the subcutaneous layer of fat.

Wikipedia ⁷⁵ Nodular nonsuppurative panniculitis: Weber-Christian disease, is a cutaneous condition characterized by recurrent subcutaneous nodules that... more...

Weber-christian disease: Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

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Related Diseases for Nodular Nonsuppurative Panniculitis

Diseases related to Nodular Nonsuppurative Panniculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)

#	Related Disease	Score	Top Affiliating Genes
1	panniculitis	31.7	SERPINA1 CRP
2	non-alcoholic fatty liver disease	29.7	TM6SF2 PNPLA3 CRP
3	mental retardation, skeletal dysplasia, and abducens palsy	10.4
4	cardiac conduction defect	10.4
5	aplastic anemia	10.4
6	alpha-1-antitrypsin deficiency	10.4
7	pancytopenia	10.4
8	pancreatic cancer	10.3
9	disseminated intravascular coagulation	10.3
10	peritonitis	10.3
11	vasculitis	10.3
12	igg4-related mesenteritis	10.3
13	ventricular fibrillation, paroxysmal familial, 1	10.3
14	glomerulonephritis	10.3
15	alopecia	10.3
16	systemic lupus erythematosus	10.3
17	nephrotic syndrome	10.3
18	histiocytosis	10.3
19	collagen disease	10.3
20	perforation of bile duct	10.2	SERPINA1 CRP
21	peroxisome biogenesis disorder 1a	10.2
22	viral laryngitis	10.2	SERPINA1 CRP
23	pleural lipoma	10.2	SERPINA1 CRP
24	constrictive pericarditis	10.2	SERPINA1 CRP
25	whipple disease	10.2	SERPINA1 CRP
26	bronchiectasis 1	10.2	SERPINA1 CRP
27	varicose veins	10.2
28	myeloma, multiple	10.2
29	deficiency anemia	10.2
30	erythema nodosum	10.2
31	mastitis	10.2
32	anterior uveitis	10.2
33	calcinosis	10.2
34	pituitary gland disease	10.2
35	retroperitoneal fibrosis	10.2
36	granulomatous mastitis	10.2
37	protein-losing enteropathy	10.2	SERPINA1 CRP
38	viral meningitis	10.2	SERPINA1 CRP
39	diverticulitis	10.2	SERPINA1 CRP
40	plasma protein metabolism disease	10.2	SERPINA1 CRP
41	coronary heart disease 1	10.1	LIPC CRP
42	pfeiffer syndrome	10.1
43	hashimoto thyroiditis	10.1
44	capillary malformation-arteriovenous malformation 1	10.1
45	leptin deficiency or dysfunction	10.1
46	leptin receptor deficiency	10.1
47	serum amyloid a amyloidosis	10.1
48	primary biliary cholangitis	10.1
49	uveitis	10.1
50	rheumatic fever	10.1

Graphical network of the top 20 diseases related to Nodular Nonsuppurative Panniculitis:

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Symptoms & Phenotypes for Nodular Nonsuppurative Panniculitis

Human phenotypes related to Nodular Nonsuppurative Panniculitis:

⁵⁸ ³⁰ (show all 15)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	nausea and vomiting ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002017
2	fever ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001945
3	subcutaneous nodule ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001482
4	abdominal pain ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002027
5	arthralgia ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002829
6	myalgia ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0003326
7	aplasia/hypoplasia of the skin ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0008065
8	erythema ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0010783
9	weight loss ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001824
10	edema ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0000969
11	panniculitis ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0012490
12	splenomegaly ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001744
13	hepatomegaly ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002240
14	autoimmunity ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002960
15	inflammatory abnormality of the eye ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100533

MGI Mouse Phenotypes related to Nodular Nonsuppurative Panniculitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system	MP:0005370	9.02	CIDEC PNPLA3 POMC RNASEH2B TM6SF2

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Drugs & Therapeutics for Nodular Nonsuppurative Panniculitis

Search Clinical Trials, NIH Clinical Center for Nodular Nonsuppurative Panniculitis

Cochrane evidence based reviews: panniculitis, nodular nonsuppurative

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Genetic Tests for Nodular Nonsuppurative Panniculitis

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Anatomical Context for Nodular Nonsuppurative Panniculitis

Organs/tissues related to Nodular Nonsuppurative Panniculitis:

MalaCards : Skin, Eye, Pancreas, Bone Marrow, Liver, Breast, Pituitary

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Publications for Nodular Nonsuppurative Panniculitis

Articles related to Nodular Nonsuppurative Panniculitis:

(show top 50) (show all 487)

#	Title	Authors	PMID	Year
1	Panniculitis as a manifestation of metal-associated autoimmune/inflammatory syndrome induced by adjuvants: a case-based review. ⁶²	Radenska-Lopovok SG...Musatov ID	34180012	2021
2	Investigating the presence of neutrophil extracellular traps in septal and lobular cutaneous panniculitides. ⁶²	Safi R...Nassar D	33580883	2021
3	Histobulin as a complementary but essential therapeutic for Intravenous Immune Globulin Therapy of Pfeiffer-Weber-Christian disease with multiple allergic diseases and its effects on allergic disease: A case report. ⁶²	Noh G	33598280	2021
4	Intravenous Immune Globulin (IVIG) Therapy After Unsuccessful Treatment with Corticosteroid and Cyclosporine A in Pfeifer-Weber-Christian Disease: A Case Report. ⁶²	Noh G...Han CW	33390586	2021
5	[Autoimmunity and autoinflammation in pathogenesis of immunoinflammatory diseases]. ⁶²	Shilkina NP...Yunonin IE	33720583	2020
6	Generalized chronic erythema nodosum: to consider Weber-Christian disease. ⁶²	Briceno-Moya F...Espinoza-Sanchez ML	34002995	2020
7	Pfeifer-Weber-Christian Disease: A Case Report and Review of Literature on Visceral Involvements and Treatment Choices. ⁶²	Rotondo C...Paolo Cantatore F	32528225	2020
8	Analysis of the clinical characteristics of thirteen patients with Weber-Christian panniculitis. ⁶²	Zheng W...Pan H	31402393	2019
9	Pfeifer-Weber-Christian disease and successful treatment with mycophenolate mofetil: a case report. ⁶²	Somalanka S...Baikunje S	31122958	2019
10	[Weber-Christian's disease: a preleukemic disorder?] ⁶²	Saghir S...Mouane N	31223415	2019
11	[Idiopathic lobular panniculitis: clinical and morphological correlations]. ⁶²	Radenska-Lopovok SG...Nagornaya DS	31317929	2019
12	Weber-Christian disease presenting with lung nodules dramatically improved with corticosteroid therapy: one case report and literature review. ⁶²	Wang Y...Zhang Z	26224252	2018
13	Weber-Christian disease: a case report. ⁶²	Brazdilova K...Payer J	30590944	2018
14	Weber-Christian Panniculitis: Is it a Disorder of Immune System? ⁶²	Kumar R...Kakkar N	26944431	2016
15	Pfeifer-Weber-Christian Disease during Pregnancy Successfully Treated with Corticosteroids. ⁶²	Platsidaki E...Polydorou D	27688468	2016
16	Sclerosing mesenteric panniculitis in a young patient : common cause of diagnostic dilemma and treatment refractoriness. ⁶²	Metha R...DattaGupta S	27382948	2016
17	Ocular Inflammation: Can It Be a Sign of Activity of Weber-Christian Disease? A Case Report and Review of Literature. ⁶²	Verrilli S...Recupero SM	25325705	2016
18	Idiopathic pleural panniculitis with recurrent pleural effusion not associated with Weber-Christian disease. ⁶²	Laperuta P...Di Crescenzo VG	28352826	2016
19	Diagnosis of extensive myocardial, pericardial, and coronary calcification in Weber-Christian disease. ⁶²	Buchner S...Endemann D	25925218	2015
20	Nephrotic syndrome in a patient with Pfeifer-Weber-Christian disease. ⁶²	Riveros Frutos A...Mateo Soria L	25543272	2015
21	Fat-Removal Orbital Decompressing for Severe Bilateral Proptosis due to Weber-Christian Disease. ⁶²	Cizmeci O...Ceran F	25978784	2015
22	Weber-Christian disease with ileocolonic involvement successfully treated with infliximab. ⁶²	Miranda-Bautista J...Menchen L	25954116	2015
23	Mycobacterium chelonae infection presenting as recurrent cutaneous and subcutaneous nodules--a presentation previously diagnosed as Weber Christian disease. ⁶²	Maverakis E...Fung MA	24945648	2014
24	Idiopatic lobular necrotizing paniculitis. ⁶²	Letkova K...Babal P	25023430	2014
25	The endemic mimic: blastomycosis an illness often misdiagnosed. ⁶²	Bradsher RW	25125734	2014
26	Panniculitis in children. ⁶²	Grassi S...Brazzelli V	23900159	2013
27	How to make a specific diagnosis of panniculitis on clinical grounds alone: an integrated pathway of general criteria and specific findings. ⁶²	Borroni G...Brazzelli V	23900156	2013
28	[Weber-Christian disease]. ⁶²	Shamov IA	24417073	2013
29	Weber-Christian disease associated with the tip variant of focal segmental glomerulosclerosis: a case report. ⁶²	Sterling KA...Cathro HP	23216240	2012
30	A 38-year old woman with a dural based lesion. ⁶²	Husain S...Raddaoui E	22497617	2012
31	Weber-Christian disease developing into mediastinitis and pleuritis with massive pleural effusion. ⁶²	Hirasaki S...Koide N	22504256	2012
32	[Lipoatrophic panniculitis in adults: treatment with hydroxychloroquine]. ⁶²	Moulonguet I...Petit A	21978506	2011
33	[A case of idiopathic sclerosing mesenteritis with retroperitoneal fibrosis]. ⁶²	Bae JH...Chang YS	22042424	2011
34	[Observation of Pfeiffer-Weber-Christian syndrome, simulating sepsis]. ⁶²	Meshkov VV...Vakulin GV	21789991	2011
35	Weber-Christian disease associated with granulomatous mastitis: a variant type of Weber-Christian disease? ⁶²	Taniguchi Y...Terada Y	20922452	2011
36	Annular lipoatrophic panniculitis of the ankles. ⁶²	Corredera C...Torrelo A	21418290	2011
37	Unusual systemic signs in a dog with sterile neutrophilic-macrophagic lymphadenitis and nodular panniculitis. ⁶²	Dandrieux JR...Francey T	21311075	2011
38	Skin lesions depicting a systemic disease. Weber-Christian disease. ⁶²	Moonen LA...Bravenboer B	21325702	2011
39	A case of Weber-Christian disease with later development of rheumatoid arthritis. ⁶²	Nanke Y...Kotake S	21372513	2011
40	Orbital lobular panniculitis in Weber-Christian disease: sustained response to anti-TNF treatment and review of the literature. ⁶²	Mavrikakis I...Sfikakis PP	20701939	2010
41	[Weber-Christian disease: unknown etiology systemic panniculitis]. ⁶²	Oliveira A...Crespo J	21627887	2010
42	Mesenteric panniculitis in Merseyside: a case series and a review of the literature. ⁶²	Nicholson JA...Scott MH	20615306	2010
43	Efficacy of cyclosporine A treatment in relapsing febrile lobular panniculitis associated with small vessel vasculitis. ⁶²	Cantarini L...Cimaz R	19506878	2010
44	A patient with Pfeifer-Weber-Christian disease--successful therapy with cyclosporin A: case report. ⁶²	Pongratz G...Fleck M	20105325	2010
45	Idiopathic lobular panniculitis: remission induced and maintained with infliximab. ⁶²	Al-Niaimi F...Burden AD	19519831	2009
46	Chorioretinitis associated with weber-christian disease. ⁶²	Saleh M...Speeg-Schatz C	25391077	2009
47	Weber and Christian of Weber-Christian disease. ⁶²	Haubrich WS	18401882	2008
48	Childhood Weber-Christian disease: clinical investigation and virus detection. ⁶²	Wu F...Zou CC	17888054	2007
49	Weber-Christian disease presenting with intractable fever and periorbital swelling mimicking angioedema. ⁶²	Wang HP...Lin HY	16550303	2007
50	Case reports: nodular vasculitis responsive to mycophenolate mofetil. ⁶²	Taverna JA...Demierre MF	17373149	2006

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Genes for Nodular Nonsuppurative Panniculitis

Genes related to Nodular Nonsuppurative Panniculitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SERPINA1	Serpin Family A Member 1	Protein Coding	5.91	DISEASES inferred ¹⁴
2	RNASEH2B	Ribonuclease H2 Subunit B	Protein Coding	4.42	DISEASES inferred ¹⁴
3	CRP	C-Reactive Protein	Protein Coding	4.34	DISEASES inferred ¹⁴
4	LIPC	Lipase C, Hepatic Type	Protein Coding	4.3	DISEASES inferred ¹⁴
5	PNPLA3	Patatin Like Phospholipase Domain Containing 3	Protein Coding	4.25	DISEASES inferred ¹⁴
6	TM6SF2	Transmembrane 6 Superfamily Member 2	Protein Coding	4.23	DISEASES inferred ¹⁴
7	PSMG4	Proteasome Assembly Chaperone 4	Protein Coding	4.16	DISEASES inferred ¹⁴
8	FANK1	Fibronectin Type III And Ankyrin Repeat Domains 1	Protein Coding	4.13	DISEASES inferred ¹⁴
9	CIDEC	Cell Death Inducing DFFA Like Effector C	Protein Coding	4.12	DISEASES inferred ¹⁴
10	POMC	Proopiomelanocortin	Protein Coding	4	DISEASES inferred ¹⁴

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Variations for Nodular Nonsuppurative Panniculitis

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Expression for Nodular Nonsuppurative Panniculitis

Search GEO for disease gene expression data for Nodular Nonsuppurative Panniculitis.

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Pathways for Nodular Nonsuppurative Panniculitis

Pathways related to Nodular Nonsuppurative Panniculitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Development_Leptin signaling via JAK/STAT and MAPK cascades ²² Show member pathways phospho-PLA2 pathway ⁶⁶	10.1	POMC CRP

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GO Terms for Nodular Nonsuppurative Panniculitis

Biological processes related to Nodular Nonsuppurative Panniculitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	triglyceride catabolic process	GO:0019433	9.26	PNPLA3 LIPC
2	lipid droplet organization	GO:0034389	8.92	PNPLA3 CIDEC

Molecular functions related to Nodular Nonsuppurative Panniculitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	triglyceride lipase activity	GO:0004806	9.46	PNPLA3 LIPC
2	low-density lipoprotein particle binding	GO:0030169	9.26	LIPC CRP
3	lipoprotein lipase activity	GO:0004465	8.92	PNPLA3 LIPC

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Sources for Nodular Nonsuppurative Panniculitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

WCD MCID: NDL003 MIFTS: 40	Nodular Nonsuppurative Panniculitis (WCD) Categories: Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes Expand all tables

Nodular Nonsuppurative Panniculitis (WCD)

Aliases & Classifications for Nodular Nonsuppurative Panniculitis

MalaCards integrated aliases for Nodular Nonsuppurative Panniculitis:

Characteristics:

Age Of Onset:

Classifications:

External Ids:

Summaries for Nodular Nonsuppurative Panniculitis

Related Diseases for Nodular Nonsuppurative Panniculitis

Diseases related to Nodular Nonsuppurative Panniculitis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Nodular Nonsuppurative Panniculitis:

Symptoms & Phenotypes for Nodular Nonsuppurative Panniculitis

Human phenotypes related to Nodular Nonsuppurative Panniculitis:

MGI Mouse Phenotypes related to Nodular Nonsuppurative Panniculitis:

Drugs & Therapeutics for Nodular Nonsuppurative Panniculitis

Cochrane evidence based reviews: panniculitis, nodular nonsuppurative

Genetic Tests for Nodular Nonsuppurative Panniculitis

Anatomical Context for Nodular Nonsuppurative Panniculitis

Organs/tissues related to Nodular Nonsuppurative Panniculitis:

Publications for Nodular Nonsuppurative Panniculitis

Articles related to Nodular Nonsuppurative Panniculitis:

Genes for Nodular Nonsuppurative Panniculitis

Genes related to Nodular Nonsuppurative Panniculitis (0 elite genes):

Variations for Nodular Nonsuppurative Panniculitis

Expression for Nodular Nonsuppurative Panniculitis

Pathways for Nodular Nonsuppurative Panniculitis

Pathways related to Nodular Nonsuppurative Panniculitis according to GeneCards Suite gene sharing:

GO Terms for Nodular Nonsuppurative Panniculitis

Biological processes related to Nodular Nonsuppurative Panniculitis according to GeneCards Suite gene sharing:

Molecular functions related to Nodular Nonsuppurative Panniculitis according to GeneCards Suite gene sharing:

Sources for Nodular Nonsuppurative Panniculitis