MCID: NDL006
MIFTS: 22

Nodular Prostate

Categories: Reproductive diseases

Aliases & Classifications for Nodular Prostate

MalaCards integrated aliases for Nodular Prostate:

Name: Nodular Prostate 12 56 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13206
ICD9CM 36 600.1
ICD10 34 N40
UMLS 74 C0748012

Summaries for Nodular Prostate

MalaCards based summary : Nodular Prostate is related to villous adenoma and small cell carcinoma. An important gene associated with Nodular Prostate is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are HIF-1-alpha transcription factor network and Coregulation of Androgen receptor activity. Affiliated tissues include prostate, and related phenotypes are Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation and integument

Related Diseases for Nodular Prostate

Diseases related to Nodular Prostate via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 villous adenoma 10.2 FOLH1 KLK3
2 small cell carcinoma 10.1 ENO2 KLK3
3 malignant epithelioid hemangioendothelioma 10.1 FOLH1 KDR
4 rete testis adenocarcinoma 10.1 ENO2 KLK3
5 proctitis 10.1 KDR KLK3
6 rete testis neoplasm 10.1 ENO2 KLK3
7 malignant hemangioma 10.1 FOLH1 KDR
8 optic nerve neoplasm 10.1 ENO2 LOX
9 optic nerve glioma 10.0 ENO2 LOX
10 adrenal rest tumor 10.0 ENO2 GNRH1
11 androgenic alopecia 10.0 AR KLK3
12 withdrawal disorder 10.0 AR KLK3
13 acute mountain sickness 10.0 ENO2 HIF1A
14 pseudovaginal perineoscrotal hypospadias 10.0 AR GNRH1
15 prostatic hypertrophy 9.9 AR KLK3
16 cystitis cystica 9.9 AR KLK3
17 ovarian hyperstimulation syndrome 9.9 GNRH1 KDR
18 limb ischemia 9.9 HIF1A KDR
19 varicocele 9.9 GNRH1 HIF1A
20 prostate small cell carcinoma 9.9 ENO2 FOLH1 KLK3
21 gynecomastia 9.9 AR KLK3
22 clear cell renal cell carcinoma 9.8 CA9 HIF1A KDR
23 prostatic hyperplasia, benign 9.8 AR FOLH1 KLK3
24 prostate disease 9.8 AR FOLH1 KLK3
25 large intestine cancer 9.8 HIF1A KDR LOX
26 suppression of tumorigenicity 12 9.8 AR FOLH1 KLK3
27 prostatic adenoma 9.8
28 adenocarcinoma 9.8
29 retinal hemangioblastoma 9.7 CA9 ENO2 HIF1A
30 hemangioma 9.7 ENO2 HIF1A KDR
31 exudative vitreoretinopathy 1 9.7 HIF1A KDR
32 renal cell carcinoma, nonpapillary 9.7 CA9 HIF1A KDR
33 male reproductive organ cancer 9.6 AR FOLH1 GNRH1 KLK3
34 male reproductive system disease 9.6 AR FOLH1 GNRH1 KLK3
35 reproductive system disease 9.6 AR FOLH1 GNRH1 KLK3
36 brain cancer 9.5 ENO2 HIF1A KDR LOX
37 ewing sarcoma 9.5 ENO2 HIF1A KDR LOX
38 prostate cancer 8.9 AR ENO2 FOLH1 GNRH1 HIF1A KLK3

Graphical network of the top 20 diseases related to Nodular Prostate:



Diseases related to Nodular Prostate

Symptoms & Phenotypes for Nodular Prostate

GenomeRNAi Phenotypes related to Nodular Prostate according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 8.92 CA9 ENO2 KDR LOX

MGI Mouse Phenotypes related to Nodular Prostate:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 AR GNRH1 HIF1A KDR LOX

Drugs & Therapeutics for Nodular Prostate

Search Clinical Trials , NIH Clinical Center for Nodular Prostate

Genetic Tests for Nodular Prostate

Anatomical Context for Nodular Prostate

MalaCards organs/tissues related to Nodular Prostate:

42
Prostate

Publications for Nodular Prostate

Variations for Nodular Prostate

Expression for Nodular Prostate

Search GEO for disease gene expression data for Nodular Prostate.

Pathways for Nodular Prostate

Pathways related to Nodular Prostate according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.25 CA9 HIF1A
2 11.16 AR KLK3
3 11.08 CA9 HIF1A KDR
4 11.07 AR KLK3
5
Show member pathways
10.98 AR KLK3
6 10.64 HIF1A KDR
7 10.48 AR HIF1A KDR
8 10.41 AR GNRH1

GO Terms for Nodular Prostate

Biological processes related to Nodular Prostate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.54 AR GNRH1 HIF1A
2 positive regulation of blood vessel endothelial cell migration GO:0043536 9.46 HIF1A KDR
3 response to testosterone GO:0033574 9.43 CA9 GNRH1
4 positive regulation of macroautophagy GO:0016239 9.4 HIF1A KDR
5 response to steroid hormone GO:0048545 9.32 GNRH1 LOX
6 blood vessel morphogenesis GO:0048514 9.26 HIF1A LOX
7 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.16 CA9 HIF1A
8 embryonic hemopoiesis GO:0035162 8.96 HIF1A KDR
9 regulation of systemic arterial blood pressure GO:0003073 8.62 AR KLK3

Molecular functions related to Nodular Prostate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Hsp90 protein binding GO:0051879 8.62 HIF1A KDR

Sources for Nodular Prostate

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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