MCID: NDL006
MIFTS: 23

Nodular Prostate

Categories: Reproductive diseases

Aliases & Classifications for Nodular Prostate

MalaCards integrated aliases for Nodular Prostate:

Name: Nodular Prostate 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13206
ICD10 33 N40
ICD9CM 35 600.1
UMLS 73 C0748012

Summaries for Nodular Prostate

MalaCards based summary : Nodular Prostate is related to villous adenoma and small cell carcinoma. An important gene associated with Nodular Prostate is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are HIF-1-alpha transcription factor network and Coregulation of Androgen receptor activity. Affiliated tissues include prostate, brain and testis, and related phenotypes are Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation and integument

Related Diseases for Nodular Prostate

Diseases related to Nodular Prostate via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 villous adenoma 10.1 FOLH1 KLK3
2 small cell carcinoma 10.1 ENO2 KLK3
3 malignant epithelioid hemangioendothelioma 10.1 FOLH1 KDR
4 rete testis adenocarcinoma 10.1 ENO2 KLK3
5 proctitis 10.1 KDR KLK3
6 rete testis neoplasm 10.1 ENO2 KLK3
7 malignant hemangioma 10.1 FOLH1 KDR
8 optic nerve neoplasm 10.0 ENO2 LOX
9 optic nerve glioma 10.0 ENO2 LOX
10 adrenal rest tumor 10.0 ENO2 GNRH1
11 androgenic alopecia 10.0 AR KLK3
12 withdrawal disorder 10.0 AR KLK3
13 acute mountain sickness 10.0 ENO2 HIF1A
14 pseudovaginal perineoscrotal hypospadias 10.0 AR GNRH1
15 prostatic hypertrophy 10.0 AR KLK3
16 cystitis cystica 10.0 AR KLK3
17 sex differentiation disease 10.0 AR GNRH1
18 ovarian hyperstimulation syndrome 10.0 GNRH1 KDR
19 limb ischemia 10.0 HIF1A KDR
20 varicocele 9.9 GNRH1 HIF1A
21 prostate small cell carcinoma 9.9 ENO2 FOLH1 KLK3
22 gynecomastia 9.9 AR KLK3
23 clear cell renal cell carcinoma 9.9 CA9 HIF1A KDR
24 prostatic hyperplasia, benign 9.9 AR FOLH1 KLK3
25 prostate disease 9.9 AR FOLH1 KLK3
26 suppression of tumorigenicity 12 9.9 AR FOLH1 KLK3
27 large intestine cancer 9.9 HIF1A KDR LOX
28 retinal hemangioblastoma 9.8 CA9 ENO2 HIF1A
29 hemangioma 9.8 ENO2 HIF1A KDR
30 exudative vitreoretinopathy 1 9.8 HIF1A KDR
31 renal cell carcinoma, nonpapillary 9.8 CA9 HIF1A KDR
32 male reproductive organ cancer 9.7 AR FOLH1 GNRH1 KLK3
33 male reproductive system disease 9.7 AR FOLH1 GNRH1 KLK3
34 reproductive system disease 9.7 AR FOLH1 GNRH1 KLK3
35 brain cancer 9.7 ENO2 HIF1A KDR LOX
36 ewing sarcoma 9.7 ENO2 HIF1A KDR LOX
37 prostate cancer 9.2 AR ENO2 FOLH1 GNRH1 HIF1A KLK3

Graphical network of the top 20 diseases related to Nodular Prostate:



Diseases related to Nodular Prostate

Symptoms & Phenotypes for Nodular Prostate

GenomeRNAi Phenotypes related to Nodular Prostate according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 8.92 CA9 ENO2 KDR LOX

MGI Mouse Phenotypes related to Nodular Prostate:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 AR GNRH1 HIF1A KDR LOX

Drugs & Therapeutics for Nodular Prostate

Search Clinical Trials , NIH Clinical Center for Nodular Prostate

Genetic Tests for Nodular Prostate

Anatomical Context for Nodular Prostate

MalaCards organs/tissues related to Nodular Prostate:

41
Prostate, Brain, Testis

Publications for Nodular Prostate

Variations for Nodular Prostate

Expression for Nodular Prostate

Search GEO for disease gene expression data for Nodular Prostate.

Pathways for Nodular Prostate

Pathways related to Nodular Prostate according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.25 CA9 HIF1A
2 11.16 AR KLK3
3 11.08 CA9 HIF1A KDR
4 11.07 AR KLK3
5
Show member pathways
10.98 AR KLK3
6 10.64 HIF1A KDR
7 10.48 AR HIF1A KDR
8 10.41 AR GNRH1

GO Terms for Nodular Prostate

Biological processes related to Nodular Prostate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.54 AR GNRH1 HIF1A
2 positive regulation of blood vessel endothelial cell migration GO:0043536 9.46 HIF1A KDR
3 response to testosterone GO:0033574 9.43 CA9 GNRH1
4 positive regulation of macroautophagy GO:0016239 9.4 HIF1A KDR
5 response to steroid hormone GO:0048545 9.32 GNRH1 LOX
6 blood vessel morphogenesis GO:0048514 9.26 HIF1A LOX
7 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.16 CA9 HIF1A
8 embryonic hemopoiesis GO:0035162 8.96 HIF1A KDR
9 regulation of systemic arterial blood pressure GO:0003073 8.62 AR KLK3

Molecular functions related to Nodular Prostate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Hsp90 protein binding GO:0051879 8.62 HIF1A KDR

Sources for Nodular Prostate

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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