Nodular Regenerative Hyperplasia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: NDL013 MIFTS: 50	Nodular Regenerative Hyperplasia Categories: Liver diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Nodular Regenerative Hyperplasia

MalaCards integrated aliases for Nodular Regenerative Hyperplasia:

Name: Nodular Regenerative Hyperplasia ⁵³ ⁷³

Nodular Regenerative Hyperplasia of the Liver ⁵³ ⁵⁹

Non-Cirrhotic Nodulation ⁵³ ⁵⁹

Non-Cirrhotic Nodular Transformation ⁵³

Miliary Hepatocellular Adenomatosis ⁵³

Non-Cirrhotic Portal Hypertension ⁵³

Nodular Hyperplasia ⁷³

Characteristics:

Orphanet epidemiological data:

⁵⁹

nodular regenerative hyperplasia of the liver
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Liver diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the digestive system

Diseases of liver

Other diseases of liver

Other specified diseases of liver

Orphanet: ⁵⁹

Rare hepatic diseases

External Ids:

Orphanet ⁵⁹ ORPHA48372

ICD10 via Orphanet ³⁴ K76.8

SNOMED-CT via HPO ⁶⁹ 34742003

UMLS ⁷³ C0020510 C4048264

Sources

Summaries for Nodular Regenerative Hyperplasia

NIH Rare Diseases : ⁵³ The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 48372Disease definitionNodular regenerative hyperplasia of the liver is a rare parenchymatous liver disease characterized by diffuse benign transformation of the hepatic parenchyma into multiple small nodules (composed of regenerating hepatocytes) and that is usually asymptomatic but can lead to the development of non-cirrhotic portal hypertension and its complications, including esophageal variceal bleeding, hypersplenism and ascites. It is often associated with rheumatologic, autoimmune, hematologic, and myeloproliferative disorders as well as various immune deficiency states and exposure certain drugs and toxins.Visit the Orphanet disease page for more resources.

MalaCards based summary : Nodular Regenerative Hyperplasia, also known as nodular regenerative hyperplasia of the liver, is related to portal hypertension and inflammatory bowel disease. An important gene associated with Nodular Regenerative Hyperplasia is NOTCH1 (Notch 1), and among its related pathways/superpathways are Notch signaling pathway (KEGG) and Th17 cell differentiation. The drugs Caffeine and Analgesics, Non-Narcotic have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related phenotypes are portal hypertension and abnormality of the hepatic vasculature

Wikipedia : ⁷⁶ Nodular regenerative hyperplasia is a form of liver hyperplasia associated with portal... more...

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Related Diseases for Nodular Regenerative Hyperplasia

Diseases related to Nodular Regenerative Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)

#	Related Disease	Score
1	portal hypertension	10.7
2	inflammatory bowel disease	10.5
3	hepatocellular carcinoma	10.4
4	biliary cirrhosis, primary, 1	10.4
5	primary biliary cirrhosis	10.4
6	lupus erythematosus	10.4
7	primary biliary cholangitis	10.4
8	systemic lupus erythematosus	10.4
9	pulmonary hypertension	10.3
10	liver disease	10.3
11	peliosis hepatis	10.3
12	hepatoportal sclerosis	10.3
13	celiac disease 1	10.3
14	common variable immunodeficiency	10.3
15	crest syndrome	10.3
16	varicose veins	10.2
17	systemic mastocytosis	10.2
18	mastocytosis	10.2
19	scleroderma, familial progressive	10.2
20	budd-chiari syndrome	10.2
21	polyarteritis nodosa, childhood-onset	10.2
22	arthritis	10.2
23	glomerulonephritis	10.2
24	lymphoma	10.2
25	thrombosis	10.2
26	polyarteritis nodosa	10.2
27	rheumatoid arthritis	10.1
28	myasthenia gravis	10.1
29	crohn's disease	10.1
30	hepatitis	10.1
31	leukemia	10.1
32	esophageal varix	10.1
33	portal vein thrombosis	10.1
34	cholestasis	10.1
35	connective tissue disease	10.1
36	vasculitis	10.1
37	macroglobulinemia	10.1
38	banti's syndrome	10.1
39	myasthenia gravis congenital	10.1
40	rheumatoid vasculitis	10.1
41	cystic fibrosis	10.1
42	gallbladder disease 1	10.1
43	inflammatory myofibroblastic tumor	10.1
44	pneumocystosis	10.1
45	dyskeratosis congenita	10.1
46	membranoproliferative glomerulonephritis	10.1
47	pancreatitis	10.1
48	human immunodeficiency virus infectious disease	10.1
49	hypersplenism	10.1
50	viral infectious disease	10.1

Graphical network of the top 20 diseases related to Nodular Regenerative Hyperplasia:

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Symptoms & Phenotypes for Nodular Regenerative Hyperplasia

Human phenotypes related to Nodular Regenerative Hyperplasia:

⁵⁹ ³²

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	portal hypertension ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0001409
2	abnormality of the hepatic vasculature ⁵⁹		Very frequent (99-80%)

MGI Mouse Phenotypes related to Nodular Regenerative Hyperplasia:

⁴⁶ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.13	EFNB2 F3 GFER ITPA JAG1 NOTCH1
2	hematopoietic system	MP:0005397	10.06	EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
3	cellular	MP:0005384	10.05	EFNB2 F3 GFER ITPA JAG1 NOTCH1
4	mortality/aging	MP:0010768	10.02	EFNB2 F3 GFER ITPA JAG1 NOTCH1
5	cardiovascular system	MP:0005385	10	EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
6	homeostasis/metabolism	MP:0005376	9.98	EFNB2 F3 GFER JAG1 NOTCH1 NOTCH2
7	embryo	MP:0005380	9.89	EFNB2 F3 JAG1 NOTCH1 NOTCH2
8	integument	MP:0010771	9.88	EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
9	muscle	MP:0005369	9.8	EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
10	neoplasm	MP:0002006	9.56	F3 GFER NOTCH1 NOTCH2
11	normal	MP:0002873	9.55	EFNB2 F3 JAG1 NOTCH1 NOTCH2
12	respiratory system	MP:0005388	9.35	EFNB2 F3 ITPA NOTCH1 NOTCH2
13	vision/eye	MP:0005391	9.02	EFNB2 F3 JAG1 NOTCH1 NOTCH2

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Drugs & Therapeutics for Nodular Regenerative Hyperplasia

Drugs for Nodular Regenerative Hyperplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Caffeine

Approved

Phase 4

58-08-2

2519

Analgesics, Non-Narcotic

Phase 4

Mesalamine

Phase 4

89-57-6

Analgesics

Phase 4

Calcium, Dietary

Phase 4

Peripheral Nervous System Agents

Phase 4,Not Applicable

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Antirheumatic Agents

Phase 4

Calcium Supplement

Phase 4

Anti-Inflammatory Agents

Phase 4

Propranolol

Approved, Investigational

Phase 3

525-66-6

4946

Liver Extracts

Phase 3,Not Applicable

Neurotransmitter Agents

Phase 3,Not Applicable

Adrenergic beta-Antagonists

Phase 3

Adrenergic Agents

Phase 3,Not Applicable

Anti-Arrhythmia Agents

Phase 3

Adrenergic Antagonists

Phase 3

Antihypertensive Agents

Phase 3

Vasodilator Agents

Phase 3

Epinephrine

Approved, Vet_approved

Not Applicable

51-43-4

5816

Racepinephrine

Approved

Not Applicable

329-65-7

838

Formaldehyde

Approved, Vet_approved

50-00-0

712

Dactinomycin

Approved, Investigational

50-76-0

457193 2019

Cyclophosphamide

Approved, Investigational

6055-19-2, 50-18-0

2907

Vincristine

Approved, Investigational

57-22-7, 2068-78-2

5978

Ifosfamide

Approved

3778-73-2

3690

Doxorubicin

Approved, Investigational

23214-92-8

31703

Etomidate

Approved

Not Applicable

33125-97-2

667484 36339

Doxil

Approved June 1999

31703

Epinephryl borate

Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Not Applicable

glucocorticoids

Not Applicable

Hormones

Not Applicable

Hormone Antagonists

Not Applicable

Coagulants

Not Applicable

Hemostatics

Not Applicable

Isophosphamide mustard

Hematinics

Not Applicable

alanine

Vasoconstrictor Agents

Not Applicable

Adrenergic beta-Agonists

Not Applicable

Anti-Asthmatic Agents

Not Applicable

Central Nervous System Depressants

Not Applicable

Mydriatics

Not Applicable

Hypnotics and Sedatives

Not Applicable

Sympathomimetics

Not Applicable

Adrenergic alpha-Agonists

Not Applicable

Autonomic Agents

Not Applicable

Adrenergic Agonists

Not Applicable

Anesthetics

Not Applicable

Interventional clinical trials:

(show all 22)

#	Name	Status	NCT ID	Phase	Drugs
1	Clinical Management of Childhood Intestinal Lymphoid Nodular Hyperplasia	Unknown status	NCT01789294	Phase 4	Mesalamine
2	Comparison of Endoscopic Variceal Ligation (EVL) With Propranolol in Non Cirrhotic Portal Hypertension (NCPH)	Completed	NCT01000779	Phase 3	Propranolol
3	SonoVue®-Enhanced Ultrasound (US) Versus Unenhanced US for Focal Liver Lesion Characterization	Completed	NCT00829413	Phase 3	SonoVue®
4	Contrast Enhanced Ultrasound For The Evaluation Of Focal Liver Lesions	Unknown status	NCT01329458
5	Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia	Unknown status	NCT02810496	Not Applicable
6	Risk Factors for Variceal Bleeding in Egyptian Patients With Non-Cirrhotic Portal Hypertension	Completed	NCT02635815
7	Quantitative Real-time Ultrasound Elastography for Characterisation of Liver Tumors	Completed	NCT02156700
8	Configuration of a New Prostate Disease Nomogram Predicting Prostate Biopsy Outcome	Completed	NCT01826617
9	Contrast Enhanced (CE) Ultrasound and CE Computed Tomography or CE Magnetic Resonance Imaging in Liver Masses	Completed	NCT00828607
10	PACE4 in Thyroid Cancer	Completed	NCT03160482
11	Superb Microvascular Imaging in Focal Nodular Hyperplasia	Recruiting	NCT02737865	Not Applicable	Sonazoid
12	Natural History of Noncirrhotic Portal Hypertension	Recruiting	NCT02417740
13	Efficacy and Tolerability of Hemopatch After Hepatic Resection	Recruiting	NCT03323359	Not Applicable
14	Vienna Vascular Liver Disease Study	Recruiting	NCT03541057
15	International PPB Registry for PPB, DICER1 and Associated Conditions	Recruiting	NCT03382158
16	Comparison of Hydro-dissection Versus Ultrasonic Aspirator in Division of Liver Parenchyma in Laparoscopic Resection	Recruiting	NCT03208192	Not Applicable
17	Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection	Recruiting	NCT03630978
18	Evaluation of Patients With Liver Disease	Recruiting	NCT00001971
19	A Nation-wide Hospital-based Hepatitis B Registry:China Registry of Hepatitis B	Recruiting	NCT03108794
20	11C-Metomidate PET Versus Adrenal Vein Sampling in Primary Aldosteronism	Active, not recruiting	NCT01567111	Not Applicable
21	Evaluation of Gastroesophageal Varices by Transnasal Endoscopy.	Enrolling by invitation	NCT02767206
22	Evaluation of the Efficacy of Contrast Enhanced Ultrasound Compared to MRI for Differentiation of Hepatic Lesions	Not yet recruiting	NCT03652636	Not Applicable

Search NIH Clinical Center for Nodular Regenerative Hyperplasia

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Genetic Tests for Nodular Regenerative Hyperplasia

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Anatomical Context for Nodular Regenerative Hyperplasia

MalaCards organs/tissues related to Nodular Regenerative Hyperplasia:

⁴¹

Liver, Bone, Bone Marrow, Kidney, T Cells, B Cells, Lung

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Publications for Nodular Regenerative Hyperplasia

Articles related to Nodular Regenerative Hyperplasia:

(show top 50) (show all 261)

#	Title	Authors	Year
1	Novel IL2RG Mutation Causes Leaky TLOWB+NK+ SCID With Nodular Regenerative Hyperplasia and Normal IL-15 STAT5 Phosphorylation. ( 29939941 )	Neves J.F....Gilmour K.	2018
2	Nodular Regenerative Hyperplasia of the Liver: A Rare Vascular Complication in Systemic Sclerosis. ( 29093156 )	Graf L....Maurer B.	2018
3	Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients. ( 29775790 )		2018
4	A case of incontinentia pigmenti associated with congenital absence of portal vein system and nodular regenerative hyperplasia. ( 30328117 )	Romano R...Giardino G	2018
5	Nodular regenerative hyperplasia in inflammatory bowel disease patients with allopurinol-thiopurine cotherapy. ( 30063483 )	Simsek M...de Boer NKH	2018
6	The Utility of MR Elastography to Differentiate Nodular Regenerative Hyperplasia from Cirrhosis. ( 30014488 )	Navin P...Venkatesh SK	2018
7	Nodular Regenerative Hyperplasia Associated With Immune Checkpoint Blockade. ( 30014512 )	LoPiccolo J...Hamilton JP	2018
8	Liver atoll sign: Nodular regenerative hyperplasia. ( 30309113 )	Xiang H...Ridley LJ	2018
9	Liver atoll sign: Nodular regenerative hyperplasia. ( 30309139 )	Xiang H...Ridley LJ	2018
10	Nodular regenerative hyperplasia rarely leads to liver transplantation: A 20-year cohort study in all Dutch liver transplant units. ( 28815029 )	Meijer B....de Boer N.K.	2017
11	Nodular Regenerative Hyperplasia: A Case of Rare Prognosis. ( 28491877 )	Lee M....Kalia H.	2017
12	A Rare Cause of Portal Hypertension: Behcet's Disease and Nodular Regenerative Hyperplasia of the Liver. ( 28465872 )	Philips C....Augustine P.	2017
13	Nodular Regenerative Hyperplasia of the Liver in Patients with IBD Treated with Allopurinol-Thiopurine Combination Therapy. ( 28151736 )	Seinen ML...van Bodegraven AA	2017
14	Nodular Regenerative Hyperplasia in HIV-positive patients : a case series and review of the literature. ( 29364092 )	Figueiredo M...Serst? T	2017
15	Epigastric Pain in a Patient With Nodular Regenerative Hyperplasia. ( 26827806 )	Fernandes D....Rolanda C.	2016
16	Ataxia telangiectasia associated with nodular regenerative hyperplasia. ( 27671921 )	Milligan K.L....Rosenzweig S.D.	2016
17	A case of idiopathic portal hypertension associated with nodular regenerative hyperplasia-like nodule of the liver and mixed connective tissue disease. ( 27151480 )		2016
18	The Prevalence of Nodular Regenerative Hyperplasia in Inflammatory Bowel Disease Patients Treated with Thioguanine Is Not Associated with Clinically Significant Liver Disease. ( 27482972 )		2016
19	P437. Short term prevalence of nodular regenerative hyperplasia of the liver in IBD patients treated with allopurinol-thiopurine combination therapy. ( 25717925 )		2015
20	Prevalence and clinical significance of nodular regenerative hyperplasia in liver biopsies. ( 26415006 )	Barge S....Ziol M.	2015
21	Diagnosing Nodular Regenerative Hyperplasia of the Liver Is Thwarted by Low Interobserver Agreement. ( 26054009 )	Jharap B....van Bodegraven A.A.	2015
22	Development of nodular regenerative hyperplasia (NRH) with portal hypertension following the administration of oxaliplatin for the recurrence of colon cancer. ( 25748953 )	Takaya H....Fukui H.	2015
23	Nodular Regenerative Hyperplasia after Liver Transplantation Complicated with Inferior Vena Cava Stenosis: a Clue for Etiopathogenesis? ( 26405712 )	Coelho R....Macedo G.	2015
24	Hepatic Lesions Caused by Large Granular Lymphocyte Leukemia in Fischer 344 Rats: Similar Morphologic Features and Morphogenesis to Those of Nodular Regenerative Hyperplasia (NRH) in the Human Liver. ( 25903270 )	Shiga A....Narama I.	2015
25	Indolent cytotoxic T cell lymphoproliferation associated with nodular regenerative hyperplasia: a common liver lesion in the context of common variable immunodeficiency disorder. ( 26493984 )	Szablewski V....Costes V.	2015
26	A case of nodular regenerative hyperplasia of the liver combined with toxic hepatitis. ( 25603855 )	Jin S.M....Rim K.S.	2015
27	Nodular Regenerative Hyperplasia in Patients Undergoing Liver Resection for Colorectal Metastases After Chemotherapy: Risk Factors, Preoperative Assessment and Clinical Impact. ( 25845431 )		2015
28	Hepatocellular carcinoma and nodular regenerative hyperplasia after chemotherapy for metastatic colorectal carcinoma. ( 24604623 )	Calderaro J....Zafrani E.S.	2014
29	Nodular Regenerative Hyperplasia After Treatment With Trastuzumab Emtansine. ( 24778392 )	Force J....Vuppalanchi R.	2014
30	Nodular regenerative hyperplasia of the liver and cutaneous T-cell lymphoma: an unreported association. ( 25075662 )	Ciria-Bru V....Nacarino-MejA-as V.	2014
31	Concurrent liver hodgkin lymphoma and nodular regenerative hyperplasia on an explanted liver with clinical diagnosis of alcoholic cirrhosis at university hospital fundaciA^n santa fe de bogotA!. ( 24511402 )	LA^pez R....Andrade R.	2014
32	Nodular Regenerative Hyperplasia Causing Portal Hypertension in a Patient with Chronic Graft versus Host Disease: Response to Sirolimus. ( 24434665 )	Choe H....Pullarkat V.	2014
33	Human immunodeficiency virus and nodular regenerative hyperplasia of liver: A systematic review. ( 24653794 )	Sood A....Saab S.	2014
34	Hepatopulmonary syndrome associated with nodular regenerative hyperplasia after liver transplantation in a child. ( 24820314 )	Alhosh R....Kerkar N.	2014
35	Splenic artery ligation for severe oxaliplatin induced portal hypertension: a way to improve postoperative course and allow adjuvant chemotherapy for colorectal liver metastases.: Letter to editor: comment about &quot;Nodular regenerative hyperplasia (NRH) complicating oxaliplatin chemotherapy in patients undergoing resection of colorectal liver metastases&quot;. ( 24613742 )		2014
36	Drug-induced nodular regenerative hyperplasia. ( 24879987 )		2014
37	Nodular regenerative hyperplasia in a patient with generalized essential telangiectasia: Endotheliopathy as causal factor. ( 24273032 )	Rothweiler S....Semela D.	2013
38	Nodular regenerative hyperplasia related portal hypertension in a patient with hypogammaglobulinaemia. ( 23801845 )	Lal B.K....Stanley A.	2013
39	Portal Hypertension, Nodular Regenerative Hyperplasia of the Liver, and Obstructive Portal Venopathy due to Metastatic Breast Cancer. ( 23984149 )	Turk A.T....Lefkowitch J.H.	2013
40	Hepatoportal sclerosis (obliterative portal venopathy) and nodular regenerative hyperplasia in a patient with myasthenia gravis: A case report and review of the published work. ( 23675894 )	Agrawal M....Schiano T.	2013
41	Nodular regenerative hyperplasia in common variable immunodeficiency. ( 23420139 )	Fuss I.J....Strober W.	2013
42	Unusual Nodular Regenerative Hyperplasia Mimicking Liver Metastases in CEUS. ( 24327467 )	HAPpfner M....LAPser C.	2013
43	Nodular regenerative hyperplasia (NRH) complicating oxaliplatin chemotherapy in patients undergoing resection of colorectal liver metastases. ( 24370284 )	Morris-Stiff G....Prasad K.R.	2013
44	Nodular regenerative hyperplasia of the liver as a complication of long-standing systemic-onset juvenile idiopathic arthritis. ( 24315465 )	Sifuentes Giraldo W.A....GA!mir GA!mir M.L.	2013
45	Patients with nodular regenerative hyperplasia should be considered for hepatocellular carcinoma screening. ( 23607291 )	Sood A....Saab S.	2013
46	Familial occurrence of nodular regenerative hyperplasia of the liver. ( 23287953 )	Albuquerque A....Macedo G.	2013
47	Downregulation of the Endothelial Genes Notch1 and EphrinB2 in Patients with Nodular Regenerative Hyperplasia. ( 23870033 )		2013
48	Review article: the association between nodular regenerative hyperplasia, inflammatory bowel disease and thiopurine therapy. ( 24099468 )		2013
49	Lengthy follow-up after liver transplantation for nodular regenerative hyperplasia in human immunodeficiency virus-infected patients: does the disease recur? ( 24296606 )		2013
50	Portal hypertension from nodular regenerative hyperplasia of the liver treated with distal splenorenal shunt. ( 24964445 )	Greene J...Livingstone A	2013

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Genes for Nodular Regenerative Hyperplasia

Genes related to Nodular Regenerative Hyperplasia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NOTCH1	Notch 1	Protein Coding	17.48	GeneCards inferred via : Publications (show sections)
2	F3	Coagulation Factor III, Tissue Factor	Protein Coding	17.13	GeneCards inferred via : Publications (show sections)
3	EFNB2	Ephrin B2	Protein Coding	17.13	GeneCards inferred via : Publications (show sections)
4	GFER	Growth Factor, Augmenter Of Liver Regeneration	Protein Coding	17.13	GeneCards inferred via : Publications (show sections)
5	JAG1	Jagged 1	Protein Coding	17.13	GeneCards inferred via : Publications (show sections)
6	ITPA	Inosine Triphosphatase	Protein Coding	17.13	GeneCards inferred via : Publications (show sections)
7	TPMT	Thiopurine S-Methyltransferase	Protein Coding	17.13	GeneCards inferred via : Publications (show sections)
8	NOTCH2	Notch 2	Protein Coding	17.13	GeneCards inferred via : Publications (show sections)
9	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	17.13	GeneCards inferred via : Publications (show sections)

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Variations for Nodular Regenerative Hyperplasia

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Expression for Nodular Regenerative Hyperplasia

Search GEO for disease gene expression data for Nodular Regenerative Hyperplasia.

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Pathways for Nodular Regenerative Hyperplasia

Pathways related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Notch signaling pathway (KEGG) ³⁷ Show member pathways Notch Signaling ⁶⁴ Notch signaling pathway ¹ Notch Signaling Pathway ¹ Notch Signaling Pathway ¹ Notch Signaling Pathways ⁶⁵	12.23	JAG1 NOTCH1 NOTCH2
2	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.21	JAG1 NOTCH1 NOTCH2
3	Wnt / Hedgehog / Notch ⁴	11.84	JAG1 NOTCH1 NOTCH2
4	NOTCH2 Activation and Transmission of Signal to the Nucleus ⁶⁶ Show member pathways Activated NOTCH1 Transmits Signal to the Nucleus ⁶⁶ Constitutive Signaling by NOTCH1 HD Domain Mutants ⁶⁶ Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1-M1580_K2555) Translocation Mutant ⁶⁶ NOTCH2 intracellular domain regulates transcription ⁶⁶ Signaling by NOTCH1 HD Domain Mutants in Cancer ⁶⁶ Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant ⁶⁶ Signaling by NOTCH2 ⁶⁶	11.59	JAG1 NOTCH1 NOTCH2
5	Primary Focal Segmental Glomerulosclerosis FSGS ¹	11.2	JAG1 NOTCH1 PCNA
6	Th2 Differentiation Pathway ⁶⁵	11.14	JAG1 NOTCH1
7	Notch Signaling Pathway (sino) ⁶⁷	11	NOTCH1 NOTCH2
8	Angiogenesis (CST) ⁴	10.97	EFNB2 F3 JAG1 NOTCH1 NOTCH2
9	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.86	ITPA TPMT
10	NOTCH1 regulation of human endothelial cell calcification ¹	10.62	JAG1 NOTCH1
11	Canonical and Non-canonical Notch signaling ¹	10.56	JAG1 NOTCH1 NOTCH2
12	Amplification and Expansion of Oncogenic Pathways as Metastatic Traits ¹	10.55	JAG1 NOTCH1

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GO Terms for Nodular Regenerative Hyperplasia

Biological processes related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

(show all 21)

#	Name	GO ID	Score	Top Affiliating Genes
1	Notch signaling pathway	GO:0007219	9.67	JAG1 NOTCH1 NOTCH2
2	animal organ morphogenesis	GO:0009887	9.65	EFNB2 JAG1 NOTCH2
3	hemopoiesis	GO:0030097	9.6	JAG1 NOTCH2
4	negative regulation of cell differentiation	GO:0045596	9.59	JAG1 NOTCH1
5	negative regulation of neuron differentiation	GO:0045665	9.58	JAG1 NOTCH1
6	positive regulation of Notch signaling pathway	GO:0045747	9.58	JAG1 NOTCH1
7	neuronal stem cell population maintenance	GO:0097150	9.57	JAG1 NOTCH1
8	aortic valve morphogenesis	GO:0003180	9.56	JAG1 NOTCH1
9	positive regulation of Ras protein signal transduction	GO:0046579	9.55	NOTCH1 NOTCH2
10	cell fate determination	GO:0001709	9.54	JAG1 NOTCH2
11	negative regulation of stem cell differentiation	GO:2000737	9.52	JAG1 NOTCH1
12	cardiac septum morphogenesis	GO:0060411	9.51	JAG1 NOTCH1
13	response to muramyl dipeptide	GO:0032495	9.46	JAG1 NOTCH1
14	venous blood vessel morphogenesis	GO:0048845	9.43	EFNB2 NOTCH1
15	regulation of developmental process	GO:0050793	9.4	NOTCH1 NOTCH2
16	distal tubule development	GO:0072017	9.37	JAG1 NOTCH1
17	negative regulation of growth rate	GO:0045967	9.32	NOTCH1 NOTCH2
18	positive regulation of aorta morphogenesis	GO:1903849	9.26	EFNB2 NOTCH1
19	positive regulation of cardiac epithelial to mesenchymal transition	GO:0062043	9.16	JAG1 NOTCH1
20	pulmonary valve morphogenesis	GO:0003184	9.13	JAG1 NOTCH1 NOTCH2
21	Notch signaling involved in heart development	GO:0061314	8.8	JAG1 NOTCH1 NOTCH2

Molecular functions related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Notch binding	GO:0005112	8.62	JAG1 NOTCH1

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Sources for Nodular Regenerative Hyperplasia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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²⁰ GeneAnalytics

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²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

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³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

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⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia