MCID: NDL013
MIFTS: 52

Nodular Regenerative Hyperplasia

Categories: Liver diseases, Rare diseases

Aliases & Classifications for Nodular Regenerative Hyperplasia

MalaCards integrated aliases for Nodular Regenerative Hyperplasia:

Name: Nodular Regenerative Hyperplasia 54 74
Nodular Regenerative Hyperplasia of the Liver 54 60
Non-Cirrhotic Nodulation 54 60
Non-Cirrhotic Nodular Transformation 54
Miliary Hepatocellular Adenomatosis 54
Non-Cirrhotic Portal Hypertension 54
Nodular Hyperplasia 74

Characteristics:

Orphanet epidemiological data:

60
nodular regenerative hyperplasia of the liver
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 60  
Rare hepatic diseases


External Ids:

ICD10 via Orphanet 35 K76.8
Orphanet 60 ORPHA48372
SNOMED-CT via HPO 70 34742003

Summaries for Nodular Regenerative Hyperplasia

NIH Rare Diseases : 54 Nodular regenerative hyperplasia (NRH) is a rare liver disease in which normal liver tissue transforms into multiple, small clusters (nodules) of replicating liver cells (regenerating hepatocytes). It can develop in people of all ages but is more common in older adults. NRH often does not cause signs or symptoms (so is likely underdiagnosed), but in some people, it leads to a type of portal hypertension called non-cirrhotic portal hypertension (NCPH). NCPH refers to abnormally high blood pressure in the portal vein (the vein that carries blood from the intestine to the liver) that is not caused by cirrhosis (scarring of liver tissue that impairs its function). NCPH typically is less severe than portal hypertension caused by cirrhosis. Symptoms of portal hypertension may include fatigue, edema, itching, jaundice, and abdominal discomfort or swelling due to fluid build-up (ascites). Complications that may develop include bleeding esophageal varices and an enlarged and overactive spleen (hypersplenism). Liver function in most people with NRH remains normal (even in those who develop NCPH), and liver failure in people with NRH and NCPH is rare. The cause of NRH is not well-understood. It is thought that the liver�??s blood vessels somehow become damaged or inflamed, impairing blood flow to parts of the liver. This in turn may cause cells in adjacent parts to �??overcompensate�?� and replicate more than they should, leading to NRH. While some people with NRH have no known underlying health problems, NRH is often associated with rheumatic, autoimmune, hematologic (blood-related), and myeloproliferative disorders; chronic or recurrent infections; immune deficiency; or exposure to certain medications or toxins. NRH may be diagnosed based on signs and symptoms (when present), liver function tests (which usually are normal), medical history (including drug or toxin exposure), imaging studies, and liver biopsy (to rule out cirrhosis). Treatment for people with NCPH may involve starting medications to prevent or treat bleeding esophageal varices, stopping medications associated with NCPH, and treating underlying health conditions associated with NCPH. The long-term outlook for people with NRH depends on whether an underlying health problem is present and whether NCPH and its complications develop (which cannot be predicted). A small proportion of people eventually need a liver transplant.

MalaCards based summary : Nodular Regenerative Hyperplasia, also known as nodular regenerative hyperplasia of the liver, is related to portal hypertension and varicose veins. An important gene associated with Nodular Regenerative Hyperplasia is NOTCH1 (Notch Receptor 1), and among its related pathways/superpathways are Notch signaling pathway (KEGG) and Th17 cell differentiation. The drugs Caffeine and Calcium have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related phenotypes are portal hypertension and abnormality of the hepatic vasculature

Wikipedia : 77 Nodular regenerative hyperplasia is a form of liver hyperplasia associated with portal... more...

Related Diseases for Nodular Regenerative Hyperplasia

Diseases related to Nodular Regenerative Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 portal hypertension 10.7
2 varicose veins 10.5
3 inflammatory bowel disease 10.5
4 hepatocellular carcinoma 10.4
5 biliary cirrhosis, primary, 1 10.4
6 primary biliary cirrhosis 10.4
7 lupus erythematosus 10.4
8 primary biliary cholangitis 10.4
9 systemic lupus erythematosus 10.4
10 pulmonary hypertension 10.3
11 liver disease 10.3
12 peliosis hepatis 10.3
13 hepatoportal sclerosis 10.3
14 celiac disease 1 10.3
15 common variable immunodeficiency 10.3
16 lymphoma 10.3
17 crest syndrome 10.3
18 systemic mastocytosis 10.2
19 mastocytosis 10.2
20 scleroderma, familial progressive 10.2
21 budd-chiari syndrome 10.2
22 polyarteritis nodosa, childhood-onset 10.2
23 arthritis 10.2
24 glomerulonephritis 10.2
25 thrombosis 10.2
26 polyarteritis nodosa 10.2
27 ossifying fibroma 10.2 JAG1 NOTCH1
28 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.1 JAG1 NOTCH1
29 granulomatous angiitis 10.1 JAG1 NOTCH1
30 rheumatoid arthritis 10.1
31 myasthenia gravis 10.1
32 membranous nephropathy 10.1
33 crohn's disease 10.1
34 hepatitis 10.1
35 leukemia 10.1
36 esophageal varix 10.1
37 portal vein thrombosis 10.1
38 cholestasis 10.1
39 connective tissue disease 10.1
40 vasculitis 10.1
41 macroglobulinemia 10.1
42 banti's syndrome 10.1
43 myasthenia gravis congenital 10.1
44 rheumatoid vasculitis 10.1
45 tricuspid valve stenosis 10.1 JAG1 NOTCH1
46 cystic fibrosis 10.1
47 gallbladder disease 1 10.1
48 inflammatory myofibroblastic tumor 10.1
49 pneumocystosis 10.1
50 hepatic coma 10.1

Graphical network of the top 20 diseases related to Nodular Regenerative Hyperplasia:



Diseases related to Nodular Regenerative Hyperplasia

Symptoms & Phenotypes for Nodular Regenerative Hyperplasia

Human phenotypes related to Nodular Regenerative Hyperplasia:

60 33
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 portal hypertension 60 33 occasional (7.5%) Occasional (29-5%) HP:0001409
2 abnormality of the hepatic vasculature 60 Very frequent (99-80%)

MGI Mouse Phenotypes related to Nodular Regenerative Hyperplasia:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.13 EFNB2 F3 GFER ITPA JAG1 NOTCH1
2 hematopoietic system MP:0005397 10.06 EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
3 cellular MP:0005384 10.05 EFNB2 F3 GFER ITPA JAG1 NOTCH1
4 mortality/aging MP:0010768 10.02 EFNB2 F3 GFER ITPA JAG1 NOTCH1
5 cardiovascular system MP:0005385 10 EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
6 homeostasis/metabolism MP:0005376 9.98 EFNB2 F3 GFER JAG1 NOTCH1 NOTCH2
7 embryo MP:0005380 9.89 EFNB2 F3 JAG1 NOTCH1 NOTCH2
8 integument MP:0010771 9.88 EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
9 muscle MP:0005369 9.8 EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
10 neoplasm MP:0002006 9.56 F3 GFER NOTCH1 NOTCH2
11 normal MP:0002873 9.55 EFNB2 F3 JAG1 NOTCH1 NOTCH2
12 respiratory system MP:0005388 9.35 EFNB2 F3 ITPA NOTCH1 NOTCH2
13 vision/eye MP:0005391 9.02 EFNB2 F3 JAG1 NOTCH1 NOTCH2

Drugs & Therapeutics for Nodular Regenerative Hyperplasia

Drugs for Nodular Regenerative Hyperplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caffeine Approved Phase 4 58-08-2 2519
2
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
3 Peripheral Nervous System Agents Phase 4,Not Applicable
4 Anti-Inflammatory Agents Phase 4
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4
6 Mesalamine Phase 4 89-57-6
7 Analgesics Phase 4
8 Calcium Supplement Phase 4
9 Calcium, Dietary Phase 4
10 Antirheumatic Agents Phase 4
11 Analgesics, Non-Narcotic Phase 4
12
Propranolol Approved, Investigational Phase 3 525-66-6 4946
13 Liver Extracts Phase 3,Not Applicable
14 Antihypertensive Agents Phase 3
15 Adrenergic Agents Phase 3,Not Applicable
16 Neurotransmitter Agents Phase 3,Not Applicable
17 Anti-Arrhythmia Agents Phase 3
18 Adrenergic beta-Antagonists Phase 3
19 Adrenergic Antagonists Phase 3
20 Vasodilator Agents Phase 3
21
Racepinephrine Approved Not Applicable 329-65-7 838
22
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
23
Etomidate Approved Not Applicable 33125-97-2 36339 667484
24
Formaldehyde Approved, Vet_approved 50-00-0 712
25
Doxorubicin Approved, Investigational 23214-92-8 31703
26
Dactinomycin Approved, Investigational 50-76-0 457193 2019
27
Cyclophosphamide Approved, Investigational 6055-19-2, 50-18-0 2907
28
Ifosfamide Approved 3778-73-2 3690
29
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
30
Doxil Approved June 1999 31703
31 Epinephryl borate Not Applicable
32 Hormone Antagonists Not Applicable
33 glucocorticoids Not Applicable
34 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
35 Hormones Not Applicable
36 Respiratory System Agents Not Applicable
37 Bronchodilator Agents Not Applicable
38 Adrenergic alpha-Agonists Not Applicable
39 Hypnotics and Sedatives Not Applicable
40 Anesthetics, General Not Applicable
41 Metomidate Not Applicable
42 Anti-Asthmatic Agents Not Applicable
43 Autonomic Agents Not Applicable
44 Vasoconstrictor Agents Not Applicable
45 Adrenergic Agonists Not Applicable
46 Sympathomimetics Not Applicable
47 Anesthetics Not Applicable
48 Anesthetics, Intravenous Not Applicable
49 Central Nervous System Depressants Not Applicable
50 Adrenergic beta-Agonists Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Clinical Management of Childhood Intestinal Lymphoid Nodular Hyperplasia Unknown status NCT01789294 Phase 4 Mesalamine
2 Comparison of Endoscopic Variceal Ligation (EVL) With Propranolol in Non Cirrhotic Portal Hypertension (NCPH) Completed NCT01000779 Phase 3 Propranolol
3 SonoVue®-Enhanced Ultrasound (US) Versus Unenhanced US for Focal Liver Lesion Characterization Completed NCT00829413 Phase 3 SonoVue®
4 Contrast Enhanced Ultrasound For The Evaluation Of Focal Liver Lesions Unknown status NCT01329458
5 Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia Unknown status NCT02810496 Not Applicable
6 Evaluation of Gastroesophageal Varices by Transnasal Endoscopy. Unknown status NCT02767206
7 Risk Factors for Variceal Bleeding in Egyptian Patients With Non-Cirrhotic Portal Hypertension Completed NCT02635815
8 Quantitative Real-time Ultrasound Elastography for Characterisation of Liver Tumors Completed NCT02156700
9 Configuration of a New Prostate Disease Nomogram Predicting Prostate Biopsy Outcome Completed NCT01826617
10 11C-Metomidate PET Versus Adrenal Vein Sampling in Primary Aldosteronism Completed NCT01567111 Not Applicable
11 Contrast Enhanced (CE) Ultrasound and CE Computed Tomography or CE Magnetic Resonance Imaging in Liver Masses Completed NCT00828607
12 PACE4 in Thyroid Cancer Completed NCT03160482
13 Superb Microvascular Imaging in Focal Nodular Hyperplasia Recruiting NCT02737865 Not Applicable Sonazoid
14 Natural History of Noncirrhotic Portal Hypertension Recruiting NCT02417740
15 Evaluation of the Efficacy of Contrast Enhanced Ultrasound Compared to MRI for Differentiation of Hepatic Lesions Recruiting NCT03652636 Not Applicable
16 Efficacy and Tolerability of Hemopatch After Hepatic Resection Recruiting NCT03323359 Not Applicable
17 Vienna Vascular Liver Disease Study Recruiting NCT03541057
18 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
19 Comparison of Hydro-dissection Versus Ultrasonic Aspirator in Division of Liver Parenchyma in Laparoscopic Resection Recruiting NCT03208192 Not Applicable
20 Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection Recruiting NCT03630978
21 Evaluation of Patients With Liver Disease Recruiting NCT00001971
22 A Nation-wide Hospital-based Hepatitis B Registry:China Registry of Hepatitis B Recruiting NCT03108794

Search NIH Clinical Center for Nodular Regenerative Hyperplasia

Genetic Tests for Nodular Regenerative Hyperplasia

Anatomical Context for Nodular Regenerative Hyperplasia

MalaCards organs/tissues related to Nodular Regenerative Hyperplasia:

42
Liver, Bone, Bone Marrow, Testes, Kidney, Spleen, Prostate

Publications for Nodular Regenerative Hyperplasia

Articles related to Nodular Regenerative Hyperplasia:

(show top 50) (show all 264)
# Title Authors Year
1
Is nodular regenerative hyperplasia an immune-mediated phenomenon ? ( 30820967 )
2019
2
In reply to: Is Nodular Regenerative Hyperplasia an Immune-Mediated Phenomenon? ( 30820976 )
2019
3
Novel IL2RG Mutation Causes Leaky TLOWB+NK+ SCID With Nodular Regenerative Hyperplasia and Normal IL-15 STAT5 Phosphorylation. ( 29939941 )
2018
4
Nodular Regenerative Hyperplasia of the Liver: A Rare Vascular Complication in Systemic Sclerosis. ( 29093156 )
2018
5
Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients. ( 29775790 )
2018
6
A case of incontinentia pigmenti associated with congenital absence of portal vein system and nodular regenerative hyperplasia. ( 30328117 )
2018
7
Nodular regenerative hyperplasia in inflammatory bowel disease patients with allopurinol-thiopurine cotherapy. ( 30063483 )
2018
8
The Utility of MR Elastography to Differentiate Nodular Regenerative Hyperplasia from Cirrhosis. ( 30014488 )
2018
9
Nodular Regenerative Hyperplasia Associated With Immune Checkpoint Blockade. ( 30014512 )
2018
10
Liver atoll sign: Nodular regenerative hyperplasia. ( 30309113 )
2018
11
Liver atoll sign: Nodular regenerative hyperplasia. ( 30309139 )
2018
12
Nodular Regenerative Hyperplasia Induced by Trastuzumab Emtansine: Role of Emtansine? ( 30600283 )
2018
13
Nodular regenerative hyperplasia rarely leads to liver transplantation: A 20-year cohort study in all Dutch liver transplant units. ( 28815029 )
2017
14
Nodular Regenerative Hyperplasia: A Case of Rare Prognosis. ( 28491877 )
2017
15
A Rare Cause of Portal Hypertension: Behcet's Disease and Nodular Regenerative Hyperplasia of the Liver. ( 28465872 )
2017
16
Nodular Regenerative Hyperplasia of the Liver in Patients with IBD Treated with Allopurinol-Thiopurine Combination Therapy. ( 28151736 )
2017
17
Nodular Regenerative Hyperplasia in HIV-positive patients : a case series and review of the literature. ( 29364092 )
2017
18
Epigastric Pain in a Patient With Nodular Regenerative Hyperplasia. ( 26827806 )
2016
19
Ataxia telangiectasia associated with nodular regenerative hyperplasia. ( 27671921 )
2016
20
A case of idiopathic portal hypertension associated with nodular regenerative hyperplasia-like nodule of the liver and mixed connective tissue disease. ( 27151480 )
2016
21
The Prevalence of Nodular Regenerative Hyperplasia in Inflammatory Bowel Disease Patients Treated with Thioguanine Is Not Associated with Clinically Significant Liver Disease. ( 27482972 )
2016
22
P437. Short term prevalence of nodular regenerative hyperplasia of the liver in IBD patients treated with allopurinol-thiopurine combination therapy. ( 25717925 )
2015
23
Prevalence and clinical significance of nodular regenerative hyperplasia in liver biopsies. ( 26415006 )
2015
24
Diagnosing Nodular Regenerative Hyperplasia of the Liver Is Thwarted by Low Interobserver Agreement. ( 26054009 )
2015
25
Development of nodular regenerative hyperplasia (NRH) with portal hypertension following the administration of oxaliplatin for the recurrence of colon cancer. ( 25748953 )
2015
26
Nodular Regenerative Hyperplasia after Liver Transplantation Complicated with Inferior Vena Cava Stenosis: a Clue for Etiopathogenesis? ( 26405712 )
2015
27
Hepatic Lesions Caused by Large Granular Lymphocyte Leukemia in Fischer 344 Rats: Similar Morphologic Features and Morphogenesis to Those of Nodular Regenerative Hyperplasia (NRH) in the Human Liver. ( 25903270 )
2015
28
Indolent cytotoxic T cell lymphoproliferation associated with nodular regenerative hyperplasia: a common liver lesion in the context of common variable immunodeficiency disorder. ( 26493984 )
2015
29
A case of nodular regenerative hyperplasia of the liver combined with toxic hepatitis. ( 25603855 )
2015
30
Nodular Regenerative Hyperplasia in Patients Undergoing Liver Resection for Colorectal Metastases After Chemotherapy: Risk Factors, Preoperative Assessment and Clinical Impact. ( 25845431 )
2015
31
Hepatocellular carcinoma and nodular regenerative hyperplasia after chemotherapy for metastatic colorectal carcinoma. ( 24604623 )
2014
32
Nodular Regenerative Hyperplasia After Treatment With Trastuzumab Emtansine. ( 24778392 )
2014
33
Nodular regenerative hyperplasia of the liver and cutaneous T-cell lymphoma: an unreported association. ( 25075662 )
2014
34
Concurrent liver hodgkin lymphoma and nodular regenerative hyperplasia on an explanted liver with clinical diagnosis of alcoholic cirrhosis at university hospital fundaciA^n santa fe de bogotA!. ( 24511402 )
2014
35
Nodular Regenerative Hyperplasia Causing Portal Hypertension in a Patient with Chronic Graft versus Host Disease: Response to Sirolimus. ( 24434665 )
2014
36
Human immunodeficiency virus and nodular regenerative hyperplasia of liver: A systematic review. ( 24653794 )
2014
37
Hepatopulmonary syndrome associated with nodular regenerative hyperplasia after liver transplantation in a child. ( 24820314 )
2014
38
Splenic artery ligation for severe oxaliplatin induced portal hypertension: a way to improve postoperative course and allow adjuvant chemotherapy for colorectal liver metastases.: Letter to editor: comment about "Nodular regenerative hyperplasia (NRH) complicating oxaliplatin chemotherapy in patients undergoing resection of colorectal liver metastases". ( 24613742 )
2014
39
Drug-induced nodular regenerative hyperplasia. ( 24879987 )
2014
40
Nodular regenerative hyperplasia in a patient with generalized essential telangiectasia: Endotheliopathy as causal factor. ( 24273032 )
2013
41
Nodular regenerative hyperplasia related portal hypertension in a patient with hypogammaglobulinaemia. ( 23801845 )
2013
42
Portal Hypertension, Nodular Regenerative Hyperplasia of the Liver, and Obstructive Portal Venopathy due to Metastatic Breast Cancer. ( 23984149 )
2013
43
Hepatoportal sclerosis (obliterative portal venopathy) and nodular regenerative hyperplasia in a patient with myasthenia gravis: A case report and review of the published work. ( 23675894 )
2013
44
Nodular regenerative hyperplasia in common variable immunodeficiency. ( 23420139 )
2013
45
Unusual Nodular Regenerative Hyperplasia Mimicking Liver Metastases in CEUS. ( 24327467 )
2013
46
Nodular regenerative hyperplasia (NRH) complicating oxaliplatin chemotherapy in patients undergoing resection of colorectal liver metastases. ( 24370284 )
2013
47
Nodular regenerative hyperplasia of the liver as a complication of long-standing systemic-onset juvenile idiopathic arthritis. ( 24315465 )
2013
48
Patients with nodular regenerative hyperplasia should be considered for hepatocellular carcinoma screening. ( 23607291 )
2013
49
Familial occurrence of nodular regenerative hyperplasia of the liver. ( 23287953 )
2013
50
Downregulation of the Endothelial Genes Notch1 and EphrinB2 in Patients with Nodular Regenerative Hyperplasia. ( 23870033 )
2013

Variations for Nodular Regenerative Hyperplasia

Expression for Nodular Regenerative Hyperplasia

Search GEO for disease gene expression data for Nodular Regenerative Hyperplasia.

Pathways for Nodular Regenerative Hyperplasia

Pathways related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.23 JAG1 NOTCH1 NOTCH2
2
Show member pathways
12.21 JAG1 NOTCH1 NOTCH2
3 11.84 JAG1 NOTCH1 NOTCH2
4
Show member pathways
11.59 JAG1 NOTCH1 NOTCH2
5 11.2 JAG1 NOTCH1 PCNA
6 11.14 JAG1 NOTCH1
7 11 NOTCH1 NOTCH2
8 10.97 EFNB2 F3 JAG1 NOTCH1 NOTCH2
9 10.86 ITPA TPMT
10 10.62 JAG1 NOTCH1
11 10.56 JAG1 NOTCH1 NOTCH2
12 10.55 JAG1 NOTCH1

GO Terms for Nodular Regenerative Hyperplasia

Biological processes related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 Notch signaling pathway GO:0007219 9.67 JAG1 NOTCH1 NOTCH2
2 animal organ morphogenesis GO:0009887 9.65 EFNB2 JAG1 NOTCH2
3 keratinocyte differentiation GO:0030216 9.61 JAG1 NOTCH1
4 hemopoiesis GO:0030097 9.6 JAG1 NOTCH2
5 negative regulation of cell differentiation GO:0045596 9.59 JAG1 NOTCH1
6 negative regulation of neuron differentiation GO:0045665 9.58 JAG1 NOTCH1
7 positive regulation of Notch signaling pathway GO:0045747 9.58 JAG1 NOTCH1
8 neuronal stem cell population maintenance GO:0097150 9.57 JAG1 NOTCH1
9 aortic valve morphogenesis GO:0003180 9.56 JAG1 NOTCH1
10 positive regulation of Ras protein signal transduction GO:0046579 9.55 NOTCH1 NOTCH2
11 cell fate determination GO:0001709 9.54 JAG1 NOTCH2
12 negative regulation of stem cell differentiation GO:2000737 9.52 JAG1 NOTCH1
13 cardiac septum morphogenesis GO:0060411 9.51 JAG1 NOTCH1
14 response to muramyl dipeptide GO:0032495 9.46 JAG1 NOTCH1
15 venous blood vessel morphogenesis GO:0048845 9.43 EFNB2 NOTCH1
16 regulation of developmental process GO:0050793 9.4 NOTCH1 NOTCH2
17 distal tubule development GO:0072017 9.37 JAG1 NOTCH1
18 negative regulation of growth rate GO:0045967 9.32 NOTCH1 NOTCH2
19 positive regulation of aorta morphogenesis GO:1903849 9.26 EFNB2 NOTCH1
20 positive regulation of cardiac epithelial to mesenchymal transition GO:0062043 9.16 JAG1 NOTCH1
21 pulmonary valve morphogenesis GO:0003184 9.13 JAG1 NOTCH1 NOTCH2
22 Notch signaling involved in heart development GO:0061314 8.8 JAG1 NOTCH1 NOTCH2

Molecular functions related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Notch binding GO:0005112 8.62 JAG1 NOTCH1

Sources for Nodular Regenerative Hyperplasia

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35 ICD10 via Orphanet
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70 SNOMED-CT via HPO
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75 UMLS via Orphanet
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