Nodular Regenerative Hyperplasia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: NDL013 MIFTS: 52	Nodular Regenerative Hyperplasia Categories: Liver diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Nodular Regenerative Hyperplasia

MalaCards integrated aliases for Nodular Regenerative Hyperplasia:

Name: Nodular Regenerative Hyperplasia ⁵⁴ ⁷⁴

Nodular Regenerative Hyperplasia of the Liver ⁵⁴ ⁶⁰

Non-Cirrhotic Nodulation ⁵⁴ ⁶⁰

Non-Cirrhotic Nodular Transformation ⁵⁴

Miliary Hepatocellular Adenomatosis ⁵⁴

Non-Cirrhotic Portal Hypertension ⁵⁴

Nodular Hyperplasia ⁷⁴

Characteristics:

Orphanet epidemiological data:

⁶⁰

nodular regenerative hyperplasia of the liver
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Liver diseases

See all MalaCards categories (disease lists)

ICD10: ³⁵

Diseases of the digestive system

Diseases of liver

Other diseases of liver

Other specified diseases of liver

Orphanet: ⁶⁰

Rare hepatic diseases

External Ids:

ICD10 via Orphanet ³⁵ K76.8

Orphanet ⁶⁰ ORPHA48372

SNOMED-CT via HPO ⁷⁰ 34742003

UMLS ⁷⁴ C0020510 C4048264

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Summaries for Nodular Regenerative Hyperplasia

NIH Rare Diseases : ⁵⁴ Nodular regenerative hyperplasia (NRH) is a rare liver disease in which normal liver tissue transforms into multiple, small clusters (nodules) of replicating liver cells (regenerating hepatocytes). It can develop in people of all ages but is more common in older adults. NRH often does not cause signs or symptoms (so is likely underdiagnosed), but in some people, it leads to a type of portal hypertension called non-cirrhotic portal hypertension (NCPH). NCPH refers to abnormally high blood pressure in the portal vein (the vein that carries blood from the intestine to the liver) that is not caused by cirrhosis (scarring of liver tissue that impairs its function). NCPH typically is less severe than portal hypertension caused by cirrhosis. Symptoms of portal hypertension may include fatigue, edema, itching, jaundice, and abdominal discomfort or swelling due to fluid build-up (ascites). Complications that may develop include bleeding esophageal varices and an enlarged and overactive spleen (hypersplenism). Liver function in most people with NRH remains normal (even in those who develop NCPH), and liver failure in people with NRH and NCPH is rare. The cause of NRH is not well-understood. It is thought that the liver�??s blood vessels somehow become damaged or inflamed, impairing blood flow to parts of the liver. This in turn may cause cells in adjacent parts to �??overcompensate�?� and replicate more than they should, leading to NRH. While some people with NRH have no known underlying health problems, NRH is often associated with rheumatic, autoimmune, hematologic (blood-related), and myeloproliferative disorders; chronic or recurrent infections; immune deficiency; or exposure to certain medications or toxins. NRH may be diagnosed based on signs and symptoms (when present), liver function tests (which usually are normal), medical history (including drug or toxin exposure), imaging studies, and liver biopsy (to rule out cirrhosis). Treatment for people with NCPH may involve starting medications to prevent or treat bleeding esophageal varices, stopping medications associated with NCPH, and treating underlying health conditions associated with NCPH. The long-term outlook for people with NRH depends on whether an underlying health problem is present and whether NCPH and its complications develop (which cannot be predicted). A small proportion of people eventually need a liver transplant.

MalaCards based summary : Nodular Regenerative Hyperplasia, also known as nodular regenerative hyperplasia of the liver, is related to portal hypertension and varicose veins. An important gene associated with Nodular Regenerative Hyperplasia is NOTCH1 (Notch Receptor 1), and among its related pathways/superpathways are Notch signaling pathway (KEGG) and Th17 cell differentiation. The drugs Caffeine and Calcium have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related phenotypes are portal hypertension and abnormality of the hepatic vasculature

Wikipedia : ⁷⁷ Nodular regenerative hyperplasia is a form of liver hyperplasia associated with portal... more...

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Related Diseases for Nodular Regenerative Hyperplasia

Diseases related to Nodular Regenerative Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)

#	Related Disease	Score	Top Affiliating Genes
1	portal hypertension	10.7
2	varicose veins	10.5
3	inflammatory bowel disease	10.5
4	hepatocellular carcinoma	10.4
5	biliary cirrhosis, primary, 1	10.4
6	primary biliary cirrhosis	10.4
7	lupus erythematosus	10.4
8	primary biliary cholangitis	10.4
9	systemic lupus erythematosus	10.4
10	pulmonary hypertension	10.3
11	liver disease	10.3
12	peliosis hepatis	10.3
13	hepatoportal sclerosis	10.3
14	celiac disease 1	10.3
15	common variable immunodeficiency	10.3
16	lymphoma	10.3
17	crest syndrome	10.3
18	systemic mastocytosis	10.2
19	mastocytosis	10.2
20	scleroderma, familial progressive	10.2
21	budd-chiari syndrome	10.2
22	polyarteritis nodosa, childhood-onset	10.2
23	arthritis	10.2
24	glomerulonephritis	10.2
25	thrombosis	10.2
26	polyarteritis nodosa	10.2
27	ossifying fibroma	10.2	JAG1 NOTCH1
28	cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	10.1	JAG1 NOTCH1
29	granulomatous angiitis	10.1	JAG1 NOTCH1
30	rheumatoid arthritis	10.1
31	myasthenia gravis	10.1
32	membranous nephropathy	10.1
33	crohn's disease	10.1
34	hepatitis	10.1
35	leukemia	10.1
36	esophageal varix	10.1
37	portal vein thrombosis	10.1
38	cholestasis	10.1
39	connective tissue disease	10.1
40	vasculitis	10.1
41	macroglobulinemia	10.1
42	banti's syndrome	10.1
43	myasthenia gravis congenital	10.1
44	rheumatoid vasculitis	10.1
45	tricuspid valve stenosis	10.1	JAG1 NOTCH1
46	cystic fibrosis	10.1
47	gallbladder disease 1	10.1
48	inflammatory myofibroblastic tumor	10.1
49	pneumocystosis	10.1
50	hepatic coma	10.1

Graphical network of the top 20 diseases related to Nodular Regenerative Hyperplasia:

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Symptoms & Phenotypes for Nodular Regenerative Hyperplasia

Human phenotypes related to Nodular Regenerative Hyperplasia:

⁶⁰ ³³

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	portal hypertension ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0001409
2	abnormality of the hepatic vasculature ⁶⁰		Very frequent (99-80%)

MGI Mouse Phenotypes related to Nodular Regenerative Hyperplasia:

⁴⁷ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.13	EFNB2 F3 GFER ITPA JAG1 NOTCH1
2	hematopoietic system	MP:0005397	10.06	EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
3	cellular	MP:0005384	10.05	EFNB2 F3 GFER ITPA JAG1 NOTCH1
4	mortality/aging	MP:0010768	10.02	EFNB2 F3 GFER ITPA JAG1 NOTCH1
5	cardiovascular system	MP:0005385	10	EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
6	homeostasis/metabolism	MP:0005376	9.98	EFNB2 F3 GFER JAG1 NOTCH1 NOTCH2
7	embryo	MP:0005380	9.89	EFNB2 F3 JAG1 NOTCH1 NOTCH2
8	integument	MP:0010771	9.88	EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
9	muscle	MP:0005369	9.8	EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
10	neoplasm	MP:0002006	9.56	F3 GFER NOTCH1 NOTCH2
11	normal	MP:0002873	9.55	EFNB2 F3 JAG1 NOTCH1 NOTCH2
12	respiratory system	MP:0005388	9.35	EFNB2 F3 ITPA NOTCH1 NOTCH2
13	vision/eye	MP:0005391	9.02	EFNB2 F3 JAG1 NOTCH1 NOTCH2

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Drugs & Therapeutics for Nodular Regenerative Hyperplasia

Drugs for Nodular Regenerative Hyperplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Caffeine

Approved

Phase 4

58-08-2

2519

Calcium

Approved, Nutraceutical

Phase 4

7440-70-2

271

Peripheral Nervous System Agents

Phase 4,Not Applicable

Anti-Inflammatory Agents

Phase 4

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Mesalamine

Phase 4

89-57-6

Analgesics

Phase 4

Calcium Supplement

Phase 4

Calcium, Dietary

Phase 4

Antirheumatic Agents

Phase 4

Analgesics, Non-Narcotic

Phase 4

Propranolol

Approved, Investigational

Phase 3

525-66-6

4946

Liver Extracts

Phase 3,Not Applicable

Antihypertensive Agents

Phase 3

Adrenergic Agents

Phase 3,Not Applicable

Neurotransmitter Agents

Phase 3,Not Applicable

Anti-Arrhythmia Agents

Phase 3

Adrenergic beta-Antagonists

Phase 3

Adrenergic Antagonists

Phase 3

Vasodilator Agents

Phase 3

Racepinephrine

Approved

Not Applicable

329-65-7

838

Epinephrine

Approved, Vet_approved

Not Applicable

51-43-4

5816

Etomidate

Approved

Not Applicable

33125-97-2

36339 667484

Formaldehyde

Approved, Vet_approved

50-00-0

712

Doxorubicin

Approved, Investigational

23214-92-8

31703

Dactinomycin

Approved, Investigational

50-76-0

457193 2019

Cyclophosphamide

Approved, Investigational

6055-19-2, 50-18-0

2907

Ifosfamide

Approved

3778-73-2

3690

Vincristine

Approved, Investigational

2068-78-2, 57-22-7

5978

Doxil

Approved June 1999

31703

Epinephryl borate

Not Applicable

Hormone Antagonists

Not Applicable

glucocorticoids

Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Not Applicable

Hormones

Not Applicable

Respiratory System Agents

Not Applicable

Bronchodilator Agents

Not Applicable

Adrenergic alpha-Agonists

Not Applicable

Hypnotics and Sedatives

Not Applicable

Anesthetics, General

Not Applicable

Metomidate

Not Applicable

Anti-Asthmatic Agents

Not Applicable

Autonomic Agents

Not Applicable

Vasoconstrictor Agents

Not Applicable

Adrenergic Agonists

Not Applicable

Sympathomimetics

Not Applicable

Anesthetics

Not Applicable

Anesthetics, Intravenous

Not Applicable

Central Nervous System Depressants

Not Applicable

Adrenergic beta-Agonists

Not Applicable

Interventional clinical trials:

(show all 22)

#	Name	Status	NCT ID	Phase	Drugs
1	Clinical Management of Childhood Intestinal Lymphoid Nodular Hyperplasia	Unknown status	NCT01789294	Phase 4	Mesalamine
2	Comparison of Endoscopic Variceal Ligation (EVL) With Propranolol in Non Cirrhotic Portal Hypertension (NCPH)	Completed	NCT01000779	Phase 3	Propranolol
3	SonoVue®-Enhanced Ultrasound (US) Versus Unenhanced US for Focal Liver Lesion Characterization	Completed	NCT00829413	Phase 3	SonoVue®
4	Contrast Enhanced Ultrasound For The Evaluation Of Focal Liver Lesions	Unknown status	NCT01329458
5	Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia	Unknown status	NCT02810496	Not Applicable
6	Evaluation of Gastroesophageal Varices by Transnasal Endoscopy.	Unknown status	NCT02767206
7	Risk Factors for Variceal Bleeding in Egyptian Patients With Non-Cirrhotic Portal Hypertension	Completed	NCT02635815
8	Quantitative Real-time Ultrasound Elastography for Characterisation of Liver Tumors	Completed	NCT02156700
9	Configuration of a New Prostate Disease Nomogram Predicting Prostate Biopsy Outcome	Completed	NCT01826617
10	11C-Metomidate PET Versus Adrenal Vein Sampling in Primary Aldosteronism	Completed	NCT01567111	Not Applicable
11	Contrast Enhanced (CE) Ultrasound and CE Computed Tomography or CE Magnetic Resonance Imaging in Liver Masses	Completed	NCT00828607
12	PACE4 in Thyroid Cancer	Completed	NCT03160482
13	Superb Microvascular Imaging in Focal Nodular Hyperplasia	Recruiting	NCT02737865	Not Applicable	Sonazoid
14	Natural History of Noncirrhotic Portal Hypertension	Recruiting	NCT02417740
15	Evaluation of the Efficacy of Contrast Enhanced Ultrasound Compared to MRI for Differentiation of Hepatic Lesions	Recruiting	NCT03652636	Not Applicable
16	Efficacy and Tolerability of Hemopatch After Hepatic Resection	Recruiting	NCT03323359	Not Applicable
17	Vienna Vascular Liver Disease Study	Recruiting	NCT03541057
18	International PPB Registry for PPB, DICER1 and Associated Conditions	Recruiting	NCT03382158
19	Comparison of Hydro-dissection Versus Ultrasonic Aspirator in Division of Liver Parenchyma in Laparoscopic Resection	Recruiting	NCT03208192	Not Applicable
20	Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection	Recruiting	NCT03630978
21	Evaluation of Patients With Liver Disease	Recruiting	NCT00001971
22	A Nation-wide Hospital-based Hepatitis B Registry:China Registry of Hepatitis B	Recruiting	NCT03108794

Search NIH Clinical Center for Nodular Regenerative Hyperplasia

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Genetic Tests for Nodular Regenerative Hyperplasia

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Anatomical Context for Nodular Regenerative Hyperplasia

MalaCards organs/tissues related to Nodular Regenerative Hyperplasia:

⁴²

Liver, Bone, Bone Marrow, Testes, Kidney, Spleen, Prostate

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Publications for Nodular Regenerative Hyperplasia

Articles related to Nodular Regenerative Hyperplasia:

(show top 50) (show all 264)

#	Title	Authors	Year
1	Is nodular regenerative hyperplasia an immune-mediated phenomenon ? ( 30820967 )	Hadzic N	2019
2	In reply to: Is Nodular Regenerative Hyperplasia an Immune-Mediated Phenomenon? ( 30820976 )	LoPiccolo J...Hamilton JP	2019
3	Novel IL2RG Mutation Causes Leaky TLOWB+NK+ SCID With Nodular Regenerative Hyperplasia and Normal IL-15 STAT5 Phosphorylation. ( 29939941 )	Neves J.F....Gilmour K.	2018
4	Nodular Regenerative Hyperplasia of the Liver: A Rare Vascular Complication in Systemic Sclerosis. ( 29093156 )	Graf L....Maurer B.	2018
5	Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients. ( 29775790 )	Simsek M....Mulder C.J.J.	2018
6	A case of incontinentia pigmenti associated with congenital absence of portal vein system and nodular regenerative hyperplasia. ( 30328117 )	Romano R...Giardino G	2018
7	Nodular regenerative hyperplasia in inflammatory bowel disease patients with allopurinol-thiopurine cotherapy. ( 30063483 )	Simsek M...de Boer NKH	2018
8	The Utility of MR Elastography to Differentiate Nodular Regenerative Hyperplasia from Cirrhosis. ( 30014488 )	Navin P...Venkatesh SK	2018
9	Nodular Regenerative Hyperplasia Associated With Immune Checkpoint Blockade. ( 30014512 )	LoPiccolo J...Hamilton JP	2018
10	Liver atoll sign: Nodular regenerative hyperplasia. ( 30309113 )	Xiang H...Ridley LJ	2018
11	Liver atoll sign: Nodular regenerative hyperplasia. ( 30309139 )	Xiang H...Ridley LJ	2018
12	Nodular Regenerative Hyperplasia Induced by Trastuzumab Emtansine: Role of Emtansine? ( 30600283 )	Lepelley M...Sturm N	2018
13	Nodular regenerative hyperplasia rarely leads to liver transplantation: A 20-year cohort study in all Dutch liver transplant units. ( 28815029 )	Meijer B....de Boer N.K.	2017
14	Nodular Regenerative Hyperplasia: A Case of Rare Prognosis. ( 28491877 )	Lee M....Kalia H.	2017
15	A Rare Cause of Portal Hypertension: Behcet's Disease and Nodular Regenerative Hyperplasia of the Liver. ( 28465872 )	Philips C....Augustine P.	2017
16	Nodular Regenerative Hyperplasia of the Liver in Patients with IBD Treated with Allopurinol-Thiopurine Combination Therapy. ( 28151736 )	Seinen M.L....van Bodegraven A.A.	2017
17	Nodular Regenerative Hyperplasia in HIV-positive patients : a case series and review of the literature. ( 29364092 )	Figueiredo M....SerstAc T.	2017
18	Epigastric Pain in a Patient With Nodular Regenerative Hyperplasia. ( 26827806 )	Fernandes D....Rolanda C.	2016
19	Ataxia telangiectasia associated with nodular regenerative hyperplasia. ( 27671921 )	Milligan K.L....Rosenzweig S.D.	2016
20	A case of idiopathic portal hypertension associated with nodular regenerative hyperplasia-like nodule of the liver and mixed connective tissue disease. ( 27151480 )	Hayano S....Kakizaki S.	2016
21	The Prevalence of Nodular Regenerative Hyperplasia in Inflammatory Bowel Disease Patients Treated with Thioguanine Is Not Associated with Clinically Significant Liver Disease. ( 27482972 )	van Asseldonk D.P....van Bodegraven A.A.	2016
22	P437. Short term prevalence of nodular regenerative hyperplasia of the liver in IBD patients treated with allopurinol-thiopurine combination therapy. ( 25717925 )		2015
23	Prevalence and clinical significance of nodular regenerative hyperplasia in liver biopsies. ( 26415006 )	Barge S....Ziol M.	2015
24	Diagnosing Nodular Regenerative Hyperplasia of the Liver Is Thwarted by Low Interobserver Agreement. ( 26054009 )	Jharap B....van Bodegraven A.A.	2015
25	Development of nodular regenerative hyperplasia (NRH) with portal hypertension following the administration of oxaliplatin for the recurrence of colon cancer. ( 25748953 )	Takaya H....Fukui H.	2015
26	Nodular Regenerative Hyperplasia after Liver Transplantation Complicated with Inferior Vena Cava Stenosis: a Clue for Etiopathogenesis? ( 26405712 )	Coelho R....Macedo G.	2015
27	Hepatic Lesions Caused by Large Granular Lymphocyte Leukemia in Fischer 344 Rats: Similar Morphologic Features and Morphogenesis to Those of Nodular Regenerative Hyperplasia (NRH) in the Human Liver. ( 25903270 )	Shiga A....Narama I.	2015
28	Indolent cytotoxic T cell lymphoproliferation associated with nodular regenerative hyperplasia: a common liver lesion in the context of common variable immunodeficiency disorder. ( 26493984 )	Szablewski V....Costes V.	2015
29	A case of nodular regenerative hyperplasia of the liver combined with toxic hepatitis. ( 25603855 )	Jin S.M....Rim K.S.	2015
30	Nodular Regenerative Hyperplasia in Patients Undergoing Liver Resection for Colorectal Metastases After Chemotherapy: Risk Factors, Preoperative Assessment and Clinical Impact. ( 25845431 )	ViganA^ L....Capussotti L.	2015
31	Hepatocellular carcinoma and nodular regenerative hyperplasia after chemotherapy for metastatic colorectal carcinoma. ( 24604623 )	Calderaro J....Zafrani E.S.	2014
32	Nodular Regenerative Hyperplasia After Treatment With Trastuzumab Emtansine. ( 24778392 )	Force J....Vuppalanchi R.	2014
33	Nodular regenerative hyperplasia of the liver and cutaneous T-cell lymphoma: an unreported association. ( 25075662 )	Ciria-Bru V....Nacarino-MejA-as V.	2014
34	Concurrent liver hodgkin lymphoma and nodular regenerative hyperplasia on an explanted liver with clinical diagnosis of alcoholic cirrhosis at university hospital fundaciA^n santa fe de bogotA!. ( 24511402 )	LA^pez R....Andrade R.	2014
35	Nodular Regenerative Hyperplasia Causing Portal Hypertension in a Patient with Chronic Graft versus Host Disease: Response to Sirolimus. ( 24434665 )	Choe H....Pullarkat V.	2014
36	Human immunodeficiency virus and nodular regenerative hyperplasia of liver: A systematic review. ( 24653794 )	Sood A....Saab S.	2014
37	Hepatopulmonary syndrome associated with nodular regenerative hyperplasia after liver transplantation in a child. ( 24820314 )	Alhosh R....Kerkar N.	2014
38	Splenic artery ligation for severe oxaliplatin induced portal hypertension: a way to improve postoperative course and allow adjuvant chemotherapy for colorectal liver metastases.: Letter to editor: comment about &quot;Nodular regenerative hyperplasia (NRH) complicating oxaliplatin chemotherapy in patients undergoing resection of colorectal liver metastases&quot;. ( 24613742 )	Schwarz L....Scatton O.	2014
39	Drug-induced nodular regenerative hyperplasia. ( 24879987 )	Ghabril M....Vuppalanchi R.	2014
40	Nodular regenerative hyperplasia in a patient with generalized essential telangiectasia: Endotheliopathy as causal factor. ( 24273032 )	Rothweiler S....Semela D.	2013
41	Nodular regenerative hyperplasia related portal hypertension in a patient with hypogammaglobulinaemia. ( 23801845 )	Lal B.K....Stanley A.	2013
42	Portal Hypertension, Nodular Regenerative Hyperplasia of the Liver, and Obstructive Portal Venopathy due to Metastatic Breast Cancer. ( 23984149 )	Turk A.T....Lefkowitch J.H.	2013
43	Hepatoportal sclerosis (obliterative portal venopathy) and nodular regenerative hyperplasia in a patient with myasthenia gravis: A case report and review of the published work. ( 23675894 )	Agrawal M....Schiano T.	2013
44	Nodular regenerative hyperplasia in common variable immunodeficiency. ( 23420139 )	Fuss I.J....Strober W.	2013
45	Unusual Nodular Regenerative Hyperplasia Mimicking Liver Metastases in CEUS. ( 24327467 )	HAPpfner M....LAPser C.	2013
46	Nodular regenerative hyperplasia (NRH) complicating oxaliplatin chemotherapy in patients undergoing resection of colorectal liver metastases. ( 24370284 )	Morris-Stiff G....Prasad K.R.	2013
47	Nodular regenerative hyperplasia of the liver as a complication of long-standing systemic-onset juvenile idiopathic arthritis. ( 24315465 )	Sifuentes Giraldo W.A....GA!mir GA!mir M.L.	2013
48	Patients with nodular regenerative hyperplasia should be considered for hepatocellular carcinoma screening. ( 23607291 )	Sood A....Saab S.	2013
49	Familial occurrence of nodular regenerative hyperplasia of the liver. ( 23287953 )	Albuquerque A....Macedo G.	2013
50	Downregulation of the Endothelial Genes Notch1 and EphrinB2 in Patients with Nodular Regenerative Hyperplasia. ( 23870033 )	Rothweiler S....Semela D.	2013

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Genes for Nodular Regenerative Hyperplasia

Genes related to Nodular Regenerative Hyperplasia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NOTCH1	Notch Receptor 1	Protein Coding	17.48	GeneCards inferred via : Publications (show sections)
2	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
3	GFER	Growth Factor, Augmenter Of Liver Regeneration	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
4	ITPA	Inosine Triphosphatase	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
5	EFNB2	Ephrin B2	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
6	F3	Coagulation Factor III, Tissue Factor	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
7	NOTCH2	Notch Receptor 2	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
8	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
9	TPMT	Thiopurine S-Methyltransferase	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)

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Variations for Nodular Regenerative Hyperplasia

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Expression for Nodular Regenerative Hyperplasia

Search GEO for disease gene expression data for Nodular Regenerative Hyperplasia.

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Pathways for Nodular Regenerative Hyperplasia

Pathways related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Notch signaling pathway (KEGG) ¹ Show member pathways Notch Signaling ⁶⁵ Notch signaling pathway ³⁸ Notch Signaling Pathway ¹ Notch Signaling Pathway ¹ Notch Signaling Pathways ⁶⁶	12.23	JAG1 NOTCH1 NOTCH2
2	Th17 cell differentiation ³⁸ Show member pathways IL-22 Pathway ⁶⁵ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease (IBD) ³⁸ Th1 and Th2 cell differentiation ³⁸	12.21	JAG1 NOTCH1 NOTCH2
3	Wnt / Hedgehog / Notch ⁴	11.84	JAG1 NOTCH1 NOTCH2
4	NOTCH2 Activation and Transmission of Signal to the Nucleus ⁶⁷ Show member pathways Activated NOTCH1 Transmits Signal to the Nucleus ⁶⁷ Constitutive Signaling by NOTCH1 HD Domain Mutants ⁶⁷ Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant ⁶⁷ NOTCH2 intracellular domain regulates transcription ⁶⁷ Signaling by NOTCH1 HD Domain Mutants in Cancer ⁶⁷ Signaling by NOTCH1 t(7;9)(NOTCH1-M1580_K2555) Translocation Mutant ⁶⁷ Signaling by NOTCH2 ⁶⁷	11.59	JAG1 NOTCH1 NOTCH2
5	Primary Focal Segmental Glomerulosclerosis FSGS ¹	11.2	JAG1 NOTCH1 PCNA
6	Th2 Differentiation Pathway ⁶⁶	11.14	JAG1 NOTCH1
7	Notch Signaling Pathway (sino) ⁶⁸	11	NOTCH1 NOTCH2
8	Angiogenesis (CST) ⁴	10.97	EFNB2 F3 JAG1 NOTCH1 NOTCH2
9	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics ⁶²	10.86	ITPA TPMT
10	NOTCH1 regulation of human endothelial cell calcification ¹	10.62	JAG1 NOTCH1
11	Canonical and Non-canonical Notch signaling ¹	10.56	JAG1 NOTCH1 NOTCH2
12	Amplification and Expansion of Oncogenic Pathways as Metastatic Traits ¹	10.55	JAG1 NOTCH1

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GO Terms for Nodular Regenerative Hyperplasia

Biological processes related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

(show all 22)

#	Name	GO ID	Score	Top Affiliating Genes
1	Notch signaling pathway	GO:0007219	9.67	JAG1 NOTCH1 NOTCH2
2	animal organ morphogenesis	GO:0009887	9.65	EFNB2 JAG1 NOTCH2
3	keratinocyte differentiation	GO:0030216	9.61	JAG1 NOTCH1
4	hemopoiesis	GO:0030097	9.6	JAG1 NOTCH2
5	negative regulation of cell differentiation	GO:0045596	9.59	JAG1 NOTCH1
6	negative regulation of neuron differentiation	GO:0045665	9.58	JAG1 NOTCH1
7	positive regulation of Notch signaling pathway	GO:0045747	9.58	JAG1 NOTCH1
8	neuronal stem cell population maintenance	GO:0097150	9.57	JAG1 NOTCH1
9	aortic valve morphogenesis	GO:0003180	9.56	JAG1 NOTCH1
10	positive regulation of Ras protein signal transduction	GO:0046579	9.55	NOTCH1 NOTCH2
11	cell fate determination	GO:0001709	9.54	JAG1 NOTCH2
12	negative regulation of stem cell differentiation	GO:2000737	9.52	JAG1 NOTCH1
13	cardiac septum morphogenesis	GO:0060411	9.51	JAG1 NOTCH1
14	response to muramyl dipeptide	GO:0032495	9.46	JAG1 NOTCH1
15	venous blood vessel morphogenesis	GO:0048845	9.43	EFNB2 NOTCH1
16	regulation of developmental process	GO:0050793	9.4	NOTCH1 NOTCH2
17	distal tubule development	GO:0072017	9.37	JAG1 NOTCH1
18	negative regulation of growth rate	GO:0045967	9.32	NOTCH1 NOTCH2
19	positive regulation of aorta morphogenesis	GO:1903849	9.26	EFNB2 NOTCH1
20	positive regulation of cardiac epithelial to mesenchymal transition	GO:0062043	9.16	JAG1 NOTCH1
21	pulmonary valve morphogenesis	GO:0003184	9.13	JAG1 NOTCH1 NOTCH2
22	Notch signaling involved in heart development	GO:0061314	8.8	JAG1 NOTCH1 NOTCH2

Molecular functions related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Notch binding	GO:0005112	8.62	JAG1 NOTCH1

Sources

Sources for Nodular Regenerative Hyperplasia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia