MCID: NDL013
MIFTS: 50

Nodular Regenerative Hyperplasia

Categories: Liver diseases, Rare diseases

Aliases & Classifications for Nodular Regenerative Hyperplasia

MalaCards integrated aliases for Nodular Regenerative Hyperplasia:

Name: Nodular Regenerative Hyperplasia 53 73
Nodular Regenerative Hyperplasia of the Liver 53 59
Non-Cirrhotic Nodulation 53 59
Non-Cirrhotic Nodular Transformation 53
Miliary Hepatocellular Adenomatosis 53
Non-Cirrhotic Portal Hypertension 53
Nodular Hyperplasia 73

Characteristics:

Orphanet epidemiological data:

59
nodular regenerative hyperplasia of the liver
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 59  
Rare hepatic diseases


External Ids:

Orphanet 59 ORPHA48372
ICD10 via Orphanet 34 K76.8
SNOMED-CT via HPO 69 34742003

Summaries for Nodular Regenerative Hyperplasia

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 48372Disease definitionNodular regenerative hyperplasia of the liver is a rare parenchymatous liver disease characterized by diffuse benign transformation of the hepatic parenchyma into multiple small nodules (composed of regenerating hepatocytes) and that is usually asymptomatic but can lead to the development of non-cirrhotic portal hypertension and its complications, including esophageal variceal bleeding, hypersplenism and ascites. It is often associated with rheumatologic, autoimmune, hematologic, and myeloproliferative disorders as well as various immune deficiency states and exposure certain drugs and toxins.Visit the Orphanet disease page for more resources.

MalaCards based summary : Nodular Regenerative Hyperplasia, also known as nodular regenerative hyperplasia of the liver, is related to portal hypertension and inflammatory bowel disease. An important gene associated with Nodular Regenerative Hyperplasia is NOTCH1 (Notch 1), and among its related pathways/superpathways are Notch signaling pathway (KEGG) and Th17 cell differentiation. The drugs Caffeine and Analgesics, Non-Narcotic have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related phenotypes are portal hypertension and abnormality of the hepatic vasculature

Wikipedia : 76 Nodular regenerative hyperplasia is a form of liver hyperplasia associated with portal... more...

Related Diseases for Nodular Regenerative Hyperplasia

Diseases related to Nodular Regenerative Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 portal hypertension 10.7
2 inflammatory bowel disease 10.5
3 hepatocellular carcinoma 10.4
4 biliary cirrhosis, primary, 1 10.4
5 primary biliary cirrhosis 10.4
6 lupus erythematosus 10.4
7 primary biliary cholangitis 10.4
8 systemic lupus erythematosus 10.4
9 pulmonary hypertension 10.3
10 liver disease 10.3
11 peliosis hepatis 10.3
12 hepatoportal sclerosis 10.3
13 celiac disease 1 10.3
14 common variable immunodeficiency 10.3
15 crest syndrome 10.3
16 varicose veins 10.2
17 systemic mastocytosis 10.2
18 mastocytosis 10.2
19 scleroderma, familial progressive 10.2
20 budd-chiari syndrome 10.2
21 polyarteritis nodosa, childhood-onset 10.2
22 arthritis 10.2
23 glomerulonephritis 10.2
24 lymphoma 10.2
25 thrombosis 10.2
26 polyarteritis nodosa 10.2
27 rheumatoid arthritis 10.1
28 myasthenia gravis 10.1
29 crohn's disease 10.1
30 hepatitis 10.1
31 leukemia 10.1
32 esophageal varix 10.1
33 portal vein thrombosis 10.1
34 cholestasis 10.1
35 connective tissue disease 10.1
36 vasculitis 10.1
37 macroglobulinemia 10.1
38 banti's syndrome 10.1
39 myasthenia gravis congenital 10.1
40 rheumatoid vasculitis 10.1
41 cystic fibrosis 10.1
42 gallbladder disease 1 10.1
43 inflammatory myofibroblastic tumor 10.1
44 pneumocystosis 10.1
45 dyskeratosis congenita 10.1
46 membranoproliferative glomerulonephritis 10.1
47 pancreatitis 10.1
48 human immunodeficiency virus infectious disease 10.1
49 hypersplenism 10.1
50 viral infectious disease 10.1

Graphical network of the top 20 diseases related to Nodular Regenerative Hyperplasia:



Diseases related to Nodular Regenerative Hyperplasia

Symptoms & Phenotypes for Nodular Regenerative Hyperplasia

Human phenotypes related to Nodular Regenerative Hyperplasia:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 portal hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0001409
2 abnormality of the hepatic vasculature 59 Very frequent (99-80%)

MGI Mouse Phenotypes related to Nodular Regenerative Hyperplasia:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.13 EFNB2 F3 GFER ITPA JAG1 NOTCH1
2 hematopoietic system MP:0005397 10.06 EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
3 cellular MP:0005384 10.05 EFNB2 F3 GFER ITPA JAG1 NOTCH1
4 mortality/aging MP:0010768 10.02 EFNB2 F3 GFER ITPA JAG1 NOTCH1
5 cardiovascular system MP:0005385 10 EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
6 homeostasis/metabolism MP:0005376 9.98 EFNB2 F3 GFER JAG1 NOTCH1 NOTCH2
7 embryo MP:0005380 9.89 EFNB2 F3 JAG1 NOTCH1 NOTCH2
8 integument MP:0010771 9.88 EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
9 muscle MP:0005369 9.8 EFNB2 F3 ITPA JAG1 NOTCH1 NOTCH2
10 neoplasm MP:0002006 9.56 F3 GFER NOTCH1 NOTCH2
11 normal MP:0002873 9.55 EFNB2 F3 JAG1 NOTCH1 NOTCH2
12 respiratory system MP:0005388 9.35 EFNB2 F3 ITPA NOTCH1 NOTCH2
13 vision/eye MP:0005391 9.02 EFNB2 F3 JAG1 NOTCH1 NOTCH2

Drugs & Therapeutics for Nodular Regenerative Hyperplasia

Drugs for Nodular Regenerative Hyperplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caffeine Approved Phase 4 58-08-2 2519
2 Analgesics, Non-Narcotic Phase 4
3 Mesalamine Phase 4 89-57-6
4 Analgesics Phase 4
5 Calcium, Dietary Phase 4
6 Peripheral Nervous System Agents Phase 4,Not Applicable
7 Anti-Inflammatory Agents, Non-Steroidal Phase 4
8 Antirheumatic Agents Phase 4
9 Calcium Supplement Phase 4
10 Anti-Inflammatory Agents Phase 4
11
Propranolol Approved, Investigational Phase 3 525-66-6 4946
12 Liver Extracts Phase 3,Not Applicable
13 Neurotransmitter Agents Phase 3,Not Applicable
14 Adrenergic beta-Antagonists Phase 3
15 Adrenergic Agents Phase 3,Not Applicable
16 Anti-Arrhythmia Agents Phase 3
17 Adrenergic Antagonists Phase 3
18 Antihypertensive Agents Phase 3
19 Vasodilator Agents Phase 3
20
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
21
Racepinephrine Approved Not Applicable 329-65-7 838
22
Formaldehyde Approved, Vet_approved 50-00-0 712
23
Dactinomycin Approved, Investigational 50-76-0 457193 2019
24
Cyclophosphamide Approved, Investigational 6055-19-2, 50-18-0 2907
25
Vincristine Approved, Investigational 57-22-7, 2068-78-2 5978
26
Ifosfamide Approved 3778-73-2 3690
27
Doxorubicin Approved, Investigational 23214-92-8 31703
28
Etomidate Approved Not Applicable 33125-97-2 667484 36339
29
Doxil Approved June 1999 31703
30 Epinephryl borate Not Applicable
31 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
32 glucocorticoids Not Applicable
33 Hormones Not Applicable
34 Hormone Antagonists Not Applicable
35 Coagulants Not Applicable
36 Hemostatics Not Applicable
37
Isophosphamide mustard 0
38 Hematinics Not Applicable
39 alanine
40 Vasoconstrictor Agents Not Applicable
41 Adrenergic beta-Agonists Not Applicable
42 Anti-Asthmatic Agents Not Applicable
43 Central Nervous System Depressants Not Applicable
44 Mydriatics Not Applicable
45 Hypnotics and Sedatives Not Applicable
46 Sympathomimetics Not Applicable
47 Adrenergic alpha-Agonists Not Applicable
48 Autonomic Agents Not Applicable
49 Adrenergic Agonists Not Applicable
50 Anesthetics Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Clinical Management of Childhood Intestinal Lymphoid Nodular Hyperplasia Unknown status NCT01789294 Phase 4 Mesalamine
2 Comparison of Endoscopic Variceal Ligation (EVL) With Propranolol in Non Cirrhotic Portal Hypertension (NCPH) Completed NCT01000779 Phase 3 Propranolol
3 SonoVue®-Enhanced Ultrasound (US) Versus Unenhanced US for Focal Liver Lesion Characterization Completed NCT00829413 Phase 3 SonoVue®
4 Contrast Enhanced Ultrasound For The Evaluation Of Focal Liver Lesions Unknown status NCT01329458
5 Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia Unknown status NCT02810496 Not Applicable
6 Risk Factors for Variceal Bleeding in Egyptian Patients With Non-Cirrhotic Portal Hypertension Completed NCT02635815
7 Quantitative Real-time Ultrasound Elastography for Characterisation of Liver Tumors Completed NCT02156700
8 Configuration of a New Prostate Disease Nomogram Predicting Prostate Biopsy Outcome Completed NCT01826617
9 Contrast Enhanced (CE) Ultrasound and CE Computed Tomography or CE Magnetic Resonance Imaging in Liver Masses Completed NCT00828607
10 PACE4 in Thyroid Cancer Completed NCT03160482
11 Superb Microvascular Imaging in Focal Nodular Hyperplasia Recruiting NCT02737865 Not Applicable Sonazoid
12 Natural History of Noncirrhotic Portal Hypertension Recruiting NCT02417740
13 Efficacy and Tolerability of Hemopatch After Hepatic Resection Recruiting NCT03323359 Not Applicable
14 Vienna Vascular Liver Disease Study Recruiting NCT03541057
15 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
16 Comparison of Hydro-dissection Versus Ultrasonic Aspirator in Division of Liver Parenchyma in Laparoscopic Resection Recruiting NCT03208192 Not Applicable
17 Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection Recruiting NCT03630978
18 Evaluation of Patients With Liver Disease Recruiting NCT00001971
19 A Nation-wide Hospital-based Hepatitis B Registry:China Registry of Hepatitis B Recruiting NCT03108794
20 11C-Metomidate PET Versus Adrenal Vein Sampling in Primary Aldosteronism Active, not recruiting NCT01567111 Not Applicable
21 Evaluation of Gastroesophageal Varices by Transnasal Endoscopy. Enrolling by invitation NCT02767206
22 Evaluation of the Efficacy of Contrast Enhanced Ultrasound Compared to MRI for Differentiation of Hepatic Lesions Not yet recruiting NCT03652636 Not Applicable

Search NIH Clinical Center for Nodular Regenerative Hyperplasia

Genetic Tests for Nodular Regenerative Hyperplasia

Anatomical Context for Nodular Regenerative Hyperplasia

MalaCards organs/tissues related to Nodular Regenerative Hyperplasia:

41
Liver, Bone, Bone Marrow, Kidney, T Cells, B Cells, Lung

Publications for Nodular Regenerative Hyperplasia

Articles related to Nodular Regenerative Hyperplasia:

(show top 50) (show all 261)
# Title Authors Year
1
Novel IL2RG Mutation Causes Leaky TLOWB+NK+ SCID With Nodular Regenerative Hyperplasia and Normal IL-15 STAT5 Phosphorylation. ( 29939941 )
2018
2
Nodular Regenerative Hyperplasia of the Liver: A Rare Vascular Complication in Systemic Sclerosis. ( 29093156 )
2018
3
Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients. ( 29775790 )
2018
4
A case of incontinentia pigmenti associated with congenital absence of portal vein system and nodular regenerative hyperplasia. ( 30328117 )
2018
5
Nodular regenerative hyperplasia in inflammatory bowel disease patients with allopurinol-thiopurine cotherapy. ( 30063483 )
2018
6
The Utility of MR Elastography to Differentiate Nodular Regenerative Hyperplasia from Cirrhosis. ( 30014488 )
2018
7
Nodular Regenerative Hyperplasia Associated With Immune Checkpoint Blockade. ( 30014512 )
2018
8
Liver atoll sign: Nodular regenerative hyperplasia. ( 30309113 )
2018
9
Liver atoll sign: Nodular regenerative hyperplasia. ( 30309139 )
2018
10
Nodular regenerative hyperplasia rarely leads to liver transplantation: A 20-year cohort study in all Dutch liver transplant units. ( 28815029 )
2017
11
Nodular Regenerative Hyperplasia: A Case of Rare Prognosis. ( 28491877 )
2017
12
A Rare Cause of Portal Hypertension: Behcet's Disease and Nodular Regenerative Hyperplasia of the Liver. ( 28465872 )
2017
13
Nodular Regenerative Hyperplasia of the Liver in Patients with IBD Treated with Allopurinol-Thiopurine Combination Therapy. ( 28151736 )
2017
14
Nodular Regenerative Hyperplasia in HIV-positive patients : a case series and review of the literature. ( 29364092 )
2017
15
Epigastric Pain in a Patient With Nodular Regenerative Hyperplasia. ( 26827806 )
2016
16
Ataxia telangiectasia associated with nodular regenerative hyperplasia. ( 27671921 )
2016
17
A case of idiopathic portal hypertension associated with nodular regenerative hyperplasia-like nodule of the liver and mixed connective tissue disease. ( 27151480 )
2016
18
The Prevalence of Nodular Regenerative Hyperplasia in Inflammatory Bowel Disease Patients Treated with Thioguanine Is Not Associated with Clinically Significant Liver Disease. ( 27482972 )
2016
19
P437. Short term prevalence of nodular regenerative hyperplasia of the liver in IBD patients treated with allopurinol-thiopurine combination therapy. ( 25717925 )
2015
20
Prevalence and clinical significance of nodular regenerative hyperplasia in liver biopsies. ( 26415006 )
2015
21
Diagnosing Nodular Regenerative Hyperplasia of the Liver Is Thwarted by Low Interobserver Agreement. ( 26054009 )
2015
22
Development of nodular regenerative hyperplasia (NRH) with portal hypertension following the administration of oxaliplatin for the recurrence of colon cancer. ( 25748953 )
2015
23
Nodular Regenerative Hyperplasia after Liver Transplantation Complicated with Inferior Vena Cava Stenosis: a Clue for Etiopathogenesis? ( 26405712 )
2015
24
Hepatic Lesions Caused by Large Granular Lymphocyte Leukemia in Fischer 344 Rats: Similar Morphologic Features and Morphogenesis to Those of Nodular Regenerative Hyperplasia (NRH) in the Human Liver. ( 25903270 )
2015
25
Indolent cytotoxic T cell lymphoproliferation associated with nodular regenerative hyperplasia: a common liver lesion in the context of common variable immunodeficiency disorder. ( 26493984 )
2015
26
A case of nodular regenerative hyperplasia of the liver combined with toxic hepatitis. ( 25603855 )
2015
27
Nodular Regenerative Hyperplasia in Patients Undergoing Liver Resection for Colorectal Metastases After Chemotherapy: Risk Factors, Preoperative Assessment and Clinical Impact. ( 25845431 )
2015
28
Hepatocellular carcinoma and nodular regenerative hyperplasia after chemotherapy for metastatic colorectal carcinoma. ( 24604623 )
2014
29
Nodular Regenerative Hyperplasia After Treatment With Trastuzumab Emtansine. ( 24778392 )
2014
30
Nodular regenerative hyperplasia of the liver and cutaneous T-cell lymphoma: an unreported association. ( 25075662 )
2014
31
Concurrent liver hodgkin lymphoma and nodular regenerative hyperplasia on an explanted liver with clinical diagnosis of alcoholic cirrhosis at university hospital fundaciA^n santa fe de bogotA!. ( 24511402 )
2014
32
Nodular Regenerative Hyperplasia Causing Portal Hypertension in a Patient with Chronic Graft versus Host Disease: Response to Sirolimus. ( 24434665 )
2014
33
Human immunodeficiency virus and nodular regenerative hyperplasia of liver: A systematic review. ( 24653794 )
2014
34
Hepatopulmonary syndrome associated with nodular regenerative hyperplasia after liver transplantation in a child. ( 24820314 )
2014
35
Splenic artery ligation for severe oxaliplatin induced portal hypertension: a way to improve postoperative course and allow adjuvant chemotherapy for colorectal liver metastases.: Letter to editor: comment about "Nodular regenerative hyperplasia (NRH) complicating oxaliplatin chemotherapy in patients undergoing resection of colorectal liver metastases". ( 24613742 )
2014
36
Drug-induced nodular regenerative hyperplasia. ( 24879987 )
2014
37
Nodular regenerative hyperplasia in a patient with generalized essential telangiectasia: Endotheliopathy as causal factor. ( 24273032 )
2013
38
Nodular regenerative hyperplasia related portal hypertension in a patient with hypogammaglobulinaemia. ( 23801845 )
2013
39
Portal Hypertension, Nodular Regenerative Hyperplasia of the Liver, and Obstructive Portal Venopathy due to Metastatic Breast Cancer. ( 23984149 )
2013
40
Hepatoportal sclerosis (obliterative portal venopathy) and nodular regenerative hyperplasia in a patient with myasthenia gravis: A case report and review of the published work. ( 23675894 )
2013
41
Nodular regenerative hyperplasia in common variable immunodeficiency. ( 23420139 )
2013
42
Unusual Nodular Regenerative Hyperplasia Mimicking Liver Metastases in CEUS. ( 24327467 )
2013
43
Nodular regenerative hyperplasia (NRH) complicating oxaliplatin chemotherapy in patients undergoing resection of colorectal liver metastases. ( 24370284 )
2013
44
Nodular regenerative hyperplasia of the liver as a complication of long-standing systemic-onset juvenile idiopathic arthritis. ( 24315465 )
2013
45
Patients with nodular regenerative hyperplasia should be considered for hepatocellular carcinoma screening. ( 23607291 )
2013
46
Familial occurrence of nodular regenerative hyperplasia of the liver. ( 23287953 )
2013
47
Downregulation of the Endothelial Genes Notch1 and EphrinB2 in Patients with Nodular Regenerative Hyperplasia. ( 23870033 )
2013
48
Review article: the association between nodular regenerative hyperplasia, inflammatory bowel disease and thiopurine therapy. ( 24099468 )
2013
49
Lengthy follow-up after liver transplantation for nodular regenerative hyperplasia in human immunodeficiency virus-infected patients: does the disease recur? ( 24296606 )
2013
50
Portal hypertension from nodular regenerative hyperplasia of the liver treated with distal splenorenal shunt. ( 24964445 )
2013

Variations for Nodular Regenerative Hyperplasia

Expression for Nodular Regenerative Hyperplasia

Search GEO for disease gene expression data for Nodular Regenerative Hyperplasia.

Pathways for Nodular Regenerative Hyperplasia

Pathways related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.23 JAG1 NOTCH1 NOTCH2
2
Show member pathways
12.21 JAG1 NOTCH1 NOTCH2
3 11.84 JAG1 NOTCH1 NOTCH2
4
Show member pathways
11.59 JAG1 NOTCH1 NOTCH2
5 11.2 JAG1 NOTCH1 PCNA
6 11.14 JAG1 NOTCH1
7 11 NOTCH1 NOTCH2
8 10.97 EFNB2 F3 JAG1 NOTCH1 NOTCH2
9 10.86 ITPA TPMT
10 10.62 JAG1 NOTCH1
11 10.56 JAG1 NOTCH1 NOTCH2
12 10.55 JAG1 NOTCH1

GO Terms for Nodular Regenerative Hyperplasia

Biological processes related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 Notch signaling pathway GO:0007219 9.67 JAG1 NOTCH1 NOTCH2
2 animal organ morphogenesis GO:0009887 9.65 EFNB2 JAG1 NOTCH2
3 hemopoiesis GO:0030097 9.6 JAG1 NOTCH2
4 negative regulation of cell differentiation GO:0045596 9.59 JAG1 NOTCH1
5 negative regulation of neuron differentiation GO:0045665 9.58 JAG1 NOTCH1
6 positive regulation of Notch signaling pathway GO:0045747 9.58 JAG1 NOTCH1
7 neuronal stem cell population maintenance GO:0097150 9.57 JAG1 NOTCH1
8 aortic valve morphogenesis GO:0003180 9.56 JAG1 NOTCH1
9 positive regulation of Ras protein signal transduction GO:0046579 9.55 NOTCH1 NOTCH2
10 cell fate determination GO:0001709 9.54 JAG1 NOTCH2
11 negative regulation of stem cell differentiation GO:2000737 9.52 JAG1 NOTCH1
12 cardiac septum morphogenesis GO:0060411 9.51 JAG1 NOTCH1
13 response to muramyl dipeptide GO:0032495 9.46 JAG1 NOTCH1
14 venous blood vessel morphogenesis GO:0048845 9.43 EFNB2 NOTCH1
15 regulation of developmental process GO:0050793 9.4 NOTCH1 NOTCH2
16 distal tubule development GO:0072017 9.37 JAG1 NOTCH1
17 negative regulation of growth rate GO:0045967 9.32 NOTCH1 NOTCH2
18 positive regulation of aorta morphogenesis GO:1903849 9.26 EFNB2 NOTCH1
19 positive regulation of cardiac epithelial to mesenchymal transition GO:0062043 9.16 JAG1 NOTCH1
20 pulmonary valve morphogenesis GO:0003184 9.13 JAG1 NOTCH1 NOTCH2
21 Notch signaling involved in heart development GO:0061314 8.8 JAG1 NOTCH1 NOTCH2

Molecular functions related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Notch binding GO:0005112 8.62 JAG1 NOTCH1

Sources for Nodular Regenerative Hyperplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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